2273results about How to "Facilitated release" patented technology

The invention discloses a sulfur-manganese composite autotrophic denitrification filler as well as a preparation method and application thereof, and belongs to the technical field of environmental functional materials and polluted water treatment. The sulfur-manganese composite autotrophic denitrification filler contains manganese salt, a sulfur-based component and a cement-based component, the manganese salt comprises one or more of manganese carbonate, calcium manganese ore and rhodochrosite; the sulfur-based component comprises sulfur and sulfur manganese ore; the cement-based component comprises cement, fly ash pottery sand, silica fume, blast furnace slag and metakaolin; the cement comprises one or more of Portland cement, iron aluminate cement and sulphoaluminate cement. The nitrogen removal efficiency of the sulfur-manganese composite autotrophic denitrification filler is superior to that of a sulfur autotrophic denitrification system, the sulfate concentration and nitrite nitrogen accumulation in effluent are remarkably reduced, the service life of the filler is prolonged, and the efficient utilization rate of the material is improved.

The invention relates to the field of traditional Chinese medicine effective component new dosage form pharmaceutical preparations, and discloses an M2 type macrophage membrane coated ROS responsive bionic nano drug delivery system, preparation and application. Mesoporous silica is used as a core to load a traditional Chinese medicine effective component, namely tripterine, and lipid components, namely PEGylated distearoyl phosphatidyl ethanolamine (DSPE-PEG), dioleoyl lecithin (DOPC), cholesterol and the like, are used as raw materials to prepare a ROS-responsive lipid coating, so that ROS-responsive tripterine mesoporous silica is formed. And then realizing bionic fusion with the M2 type macrophage membrane on the outer layer through an ultrasonic coating technology to prepare the M2 type macrophage membrane coated ROS responsive bionic mesoporous silica nano drug delivery system. The invention can realize targeted therapy of rheumatoid arthritis, and has the advantages of biological safety and the like.

The invention relates to a weight-losing enzyme and a preparation method thereof, and belongs to the technical field of biology, and the weight-losing enzyme comprises a fruit enzyme, a vegetable enzyme, a seed enzyme and a lotus leaf extract; the fruit enzyme is obtained by performing enzymolysis on mixed fruit pulp of apples, lemons, grapefruits and haws through pectinase, performing enzymolysis through pepsase and performing co-fermentation through bifidobacterium longum and lactobacillus acidophilus; the vegetable enzyme is obtained by performing enzymolysis on mixed vegetable pulp of wax gourd pulp, celery and spinach through pectinase, performing enzymolysis through pepsin and performing fermentation through lactobacillus plantarum and bifidobacterium adolescentis; the seed enzyme is obtained by carrying out trypsin enzymolysis on mixed powder of semen raphani and phaseolus calcaratus, then carrying out nattokinase enzymolysis and then fermenting with bifidobacterium breve; the lotus leaf extract is obtained by sequentially carrying out enzymolysis on lotus leaves through hemicellulase, snail protease and nattokinase. All the components are matched for use, so that the weight-losing food has the effects of promoting digestion, inhibiting fat absorption, regulating intestinal flora, promoting metabolism and the like, and has a good weight-losing effect.

The invention provides velvet antler mushroom sporocarp water extraction residue polysaccharide as well as an extraction method and application thereof, and belongs to the technical field of edible mushroom polysaccharide preparation. The invention provides an extraction method of water extraction residue polysaccharide of a mushroom fruiting body, which comprises the following steps: sequentially carrying out solid state fermentation, post-treatment and hot water extraction on the water extraction residue of the mushroom fruiting body to obtain an extraction product containing the water extraction residue polysaccharide of the mushroom fruiting body. According to the method disclosed by the invention, the water extraction residues of the pilose antler mushroom sporocarp are used as raw materials, so that high-value utilization of the water extraction residues of the pilose antler mushroom sporocarp can be realized. Moreover, the method can improve the yield and content of polysaccharide, and has the advantages of no chemical residue, ecological environmental protection, high production efficiency and the like. Besides, the polysaccharide prepared by the extraction method disclosed by the invention is stable under a digestion condition, and the prepared polysaccharide can improve the content of short-chain fatty acids in intestinal tracts, so that a basis is provided for application of the polysaccharide of the water-extracted residues of the fruiting bodies of the velvet antler mushrooms in new potential prebiotics.

The invention provides a coal gangue organic fertilizer and a preparation method thereof, and belongs to the technical field of fertilizers. The coal gangue organic fertilizer is prepared by uniformly mixing modified coal gangue, forestry and agricultural residues and a microbial agent, performing high-temperature aerobic composting and aging. Organic components of the coal gangue and nutrient elements such as nitrogen, phosphorus, potassium, calcium and the like required by plant growth are fully utilized, the carrier effect of the coal gangue is also played, and the coal gangue organic fertilizer prepared from the modified coal gangue has a relatively high decomposition degree and is greatly beneficial to seed growth. According to the invention, on one hand, the problems of large stockpiling land occupation and environmental pollution of coal gangue, forestry and agricultural residues and other solid wastes are relieved, and on the other hand, the prepared organic fertilizer can turn waste into wealth and realize solid waste recycling.

The invention provides analcime based on alkali grinding activation as well as a preparation method and application of the analcime. The preparation method of analcime comprises the following steps: S1, providing lithium slag; s2, ball-milling the solid material and water together to obtain a ball-milled product; the solid material comprises the lithium slag and an alkaline auxiliary material, and the alkaline auxiliary material comprises one or more of sodium hydroxide and potassium hydroxide; s3, mixing the ball-milled product with an alkaline solution to obtain a to-be-treated solution; performing hydro-thermal treatment on the to-be-treated liquid to obtain reaction liquid; and S4, carrying out solid-liquid separation on the reaction liquid to obtain a solid isolate containing analcime. The analcime with high crystallinity and high yield can be obtained, a new way is provided for preparation of the analcime, and a new way is also provided for resourceful treatment of the lithium slag.

The invention belongs to the technical field of batteries, and particularly relates to a lithium ferrite lithium supplement agent and a preparation method and application thereof. Compared with the prior art, a solid electrolyte coating layer is formed on the surface of the carbon-doped lithium iron oxide material through a low-temperature molten salt method, so that air can be effectively isolated, the air stability of the material is improved, the lithium removal phenomenon is reduced, and the structural integrity and lithium supplement performance of the material are kept; and the lithium ferrite lithium supplement agent combines the high theoretical lithium supplement capacity of Li5FeO4 and the excellent ionic conductivity of the solid electrolyte, so that the electrochemical performance of the material can be improved while the high lithium supplement capacity is maintained, and a new technical scheme is provided for commercial application of the high-energy-density lithium ion battery.

The invention discloses double-layer hydrogel for wound repair and infection monitoring as well as a preparation method and application of the double-layer hydrogel, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: (1) firstly, preparing an aldehyde dextran-mulberry extract solution; (2) preparing a chitosan quaternary ammonium salt-mulberry extract solution; (3) mixing and dissolving sodium alginate, aldehyde dextran and mulberry extract in a PBS (Phosphate Buffer Solution), so as to obtain an upper-layer hydrogel pre-polymerization solution; (4) mixing the aldehyde dextran-mulberry extract solution with the chitosan quaternary ammonium salt-mulberry extract solution, so as to prepare a lower layer hydrogel; and (5) adding the upper-layer hydrogel prepolymerization liquid above the lower-layer hydrogel, and spraying a metal cation salt solution to enable the upper-layer hydrogel to be fully crosslinked, thereby obtaining the crosslinked hydrogel with a double-layer structure. The double-layer hydrogel for wound repair and infection monitoring, prepared by the invention, has good adhesion, tensile property, antibacterial property and hemostatic property.

The invention relates to a container ship methanol fuel daily cabin arrangement form, and belongs to the technical field of ship design and manufacture, the container ship methanol fuel daily cabin arrangement form comprises a methanol fuel daily cabin and a methanol fuel preparation room, the methanol fuel daily cabin is arranged on one side of an engine room above a main deck, and the methanol fuel preparation room is arranged on one side of an engine room below the main deck; and the methanol fuel daily cabin and the methanol fuel preparation room are adjacently arranged up and down. For a large container ship, the length of a traditional cabin shed is generally about 6 m, and in order to guarantee the volume of the methanol fuel daily cabin, the width of the methanol fuel daily cabin and the height of a top deck can be adjusted according to needs.

The invention discloses a dependency-free anti-aging sleep-aiding preparation and a preparation method thereof, and relates to the technical field of preparations, the anti-aging sleep-aiding preparation comprises an ellipsoidal shell and an ellipsoidal core wrapped in the ellipsoidal shell, the ellipsoidal core comprises an anti-aging agent layer, a water absorption expansion layer and a sleep-aiding agent layer which are stacked in sequence, the water absorption expansion layer protrudes at the two ends of the ellipsoidal core to form small water diversion columns; small water inlet holes are formed in the two ends of the ellipsoidal shell and are connected with small water diversion columns; a plurality of first release holes and a plurality of second release holes are formed in the circumferential surface of the ellipsoidal shell, the plurality of first release holes lead to the anti-aging agent layer, and the plurality of second release holes lead to the sleep aid layer. Through the special structural design of the ellipsoidal shell and the ellipsoidal core, isolated coexistence of anti-aging and sleep-aiding components and controllable release of the anti-aging and sleep-aiding components are achieved, so that the dual effects of anti-aging and sleep-aiding can be achieved, and it is guaranteed that the drug effect is continuously exerted.

The invention discloses a silica gel material and a preparation method thereof, a silica gel tube, an implant and a preparation method and application thereof. The silica gel material comprises the following components in parts by weight: 100 parts of R-vinyl polysiloxane; 10 to 80 parts of a reinforcing agent; 0.000002 to 1 part of a catalyst; wherein R in the R-vinyl polysiloxane is substituted or unsubstituted straight-chain alkane or branched alkane of C1-C5, and substituted or unsubstituted aromatic hydrocarbon of C6-C20, and R in the R-vinyl polysiloxane is substituted or unsubstituted straight-chain alkane or branched alkane of C1-C5, or substituted or unsubstituted aromatic hydrocarbon of C6-C20; the content of vinyl in the R-vinyl polysiloxane ranges from 0.1 mol% to 0.5 mol%; the components contained in the reinforcing agent comprise hydrophilic groups; the content of Si-H groups in the hydrogen-containing silicone oil is 0.18 mol% to 1.6 mol%; the molar ratio of the Si-H group in the hydrogen-containing silicone oil to the vinyl group in the R-vinyl polysiloxane is (0.5-10): 1; optionally, the composition also comprises an inhibitor. According to the silica gel material provided by the invention, the permeability of water to the silica gel tube is increased while the mechanical property is met, so that the release amount of a medicine is increased, and the defect of low in-vitro release degree in the prior art is improved.

The invention belongs to the field of wastewater treatment. The invention provides a manganese-carbon composite controlled-release material as well as a preparation method and application thereof. The manganese-carbon composite controlled-release material comprises the following components: a manganese-rich mineral, a natural plant carbon source, a cementing material, aggregate, an additive and a foaming agent. The manganese-carbon composite controlled-release material disclosed by the invention can regulate and control the carbon release and manganese circulation process by virtue of the interaction between manganese and carbon, so that the electron transfer and mass transfer efficiency is remarkably improved, synergistic denitrification is realized, the overall denitrification efficiency is remarkably improved, and synchronous nitrogen and phosphorus removal and self-adaptive continuous denitrification are realized. The raw materials required for preparing the manganese-carbon composite controlled-release material are environment-friendly and low in price, the preparation process is simple, the preparation cost is low, and the manganese-carbon composite controlled-release material can be applied to filler in a submerged area of an artificial wetland, a biological filter and a biological retention system, and can be widely applied to application scenes such as tail water advanced treatment of a sewage treatment plant, rural agricultural sewage treatment and initial rainwater purification.

The invention discloses a hollow skeleton type drug-loading rod core as well as a preparation method and application thereof. The raw material composition comprises the following components in parts by weight: 1-1000 parts of active pharmaceutical ingredients; 100 parts of R-vinyl silicone rubber; 0.45 to 20 parts of hydrogen-containing silicone oil; more than or equal to 0.000002 parts of a catalyst; the content of vinyl in the R-vinyl silicone rubber is 0.1-0.5 mol%; the content of Si-H groups in the hydrogen-containing silicone oil is 0.18 to 1.6 mol%; the molar ratio of the Si-H group to the vinyl group is (0.5-20): 1. According to the invention, methyl vinyl silicone rubber, hydrogen-containing silicone oil, a platinum catalyst and other components are taken as a basic prescription of silicone rubber, and a model drug and the silicone rubber are mixed by using an extrusion technology to prepare the hollow skeleton type drug-loaded rod core. Advantages of traditional storage type implants and skeleton type implants are integrated, the production process is simple, the medicine application range is wide, the release amount is stable, and the release amount is large.

The invention belongs to the technical field of microbial organic fertilizers, and provides a microbial organic fertilizer and a preparation method thereof.The preparation method specifically comprises the following steps that modified attapulgite, an adhesive, water and a trace element fertilizer are weighed according to the weight part, and after the modified attapulgite, the adhesive, the water and the trace element fertilizer are evenly mixed, a coating agent is obtained; weighing according to parts by weight, crushing and grinding the organic fertilizer, mixing with the microbial agent, fermenting, and airing; mixing the air-dried fertilizer with an inorganic fertilizer, performing secondary crushing and grinding, and sieving to obtain a mixture; and finally, uniformly mixing the obtained mixture with a coating agent, and drying to obtain the microbial organic fertilizer. The microbial organic fertilizer provided by the invention can effectively prevent the caking problem of the fertilizer, and can also reduce the nutrient loss and reduce the pollution to the environment; meanwhile, the preparation process is simple, low in cost and suitable for large-scale production.

The invention discloses lactobacillus reuteri CCFM1288 for relieving depressive mood and application of the lactobacillus reuteri CCFM1288, and belongs to the technical field of microorganisms. The lactobacillus reuteri CCFM1288 has the tryptophan metabolism capability, and can survive for 7 days in the intestinal tract; after the lactobacillus reuteri CCFM1288 intervenes a depressive mouse, anxiety-like and depression-like behaviors of the mouse can be obviously relieved, flora alpha-diversity is improved, intestinal symbiotic bacteria are promoted to secrete indole substances, intestinal homeostasis is maintained, hypothalamic-pituitary-adrenal axis hyperfunction is relieved, dopamine and serotonin neurotransmitter nervous system functions are improved, and the effect of preventing and treating depression is achieved. The neurotransmitter release is promoted, and the anti-depression effect is achieved. In clinical tests, intervention of Lactobacillus reuteri CCFM1288 can significantly improve the depressive symptom of MDD patients, and a new safe alleviation approach is provided for depression treatment.

The invention belongs to the technical field of biological medicines, and discloses an angiotensin I converting enzyme inhibitory peptide. According to the present invention, the action mechanisms of two ACE inhibitory peptides H5 (LIIPQH, 719.85 Da) and H6 (LIIPEH, 720.85 Da) extracted, separated and purified from rice wine residue are researched, and the in vitro activity of the ACE inhibitory peptides is researched through an EA.hy926 cell model, such that the two ACE inhibitory peptides can provide the activity effect by promoting the release of NO, the expression of eNOS and SOD, and inhibiting the release secretion of ET-1 and the release of ROS; meanwhile, the cells are subjected to transcriptomics analysis, and the pathway mechanism of polypeptide action is defined. The ACE inhibitory peptide is expected to serve as a potential antihypertensive drug or a functional food ingredient, the high-value utilization of the rice wine residues is improved, and a new application way is provided for the food-borne ACE inhibitory peptide in the aspect of treating hypertension.

The invention discloses an optical module which comprises a circuit board and a lens assembly, and a first sealing piece is arranged between the lens assembly and the circuit board. One end of the first lens assembly is provided with a wrapping cavity. A light port groove, a blocking piece and a third sealing piece are arranged on the light source module, the third sealing piece is located on the outer side wall of the blocking piece, the blocking piece covers the light port groove, and the light port groove is provided with a reflecting surface; the optical fiber bracket is fixed in the wrapping cavity; the first end face of the optical fiber support is buried in the wrapping cavity, a second sealing piece is arranged between the optical fiber support and the wrapping cavity, the wrapping cavity is provided with a first air hole, the spreading range of the second sealing piece in a gap between the top face of the optical fiber support and the wrapping cavity does not exceed the first air hole, and a twelfth sealing piece is arranged in the first air hole. According to the cooling device, the twelfth sealing piece is arranged in the first sealing piece, the second sealing piece, the blocking piece and the first air hole, so that cooling liquid is isolated; the sealing glue is isolated by embedding the first end face of the optical fiber support in the wrapping cavity.

The invention discloses a preparation method of a zinc-dihydromyricetin nano-enzyme and application of the zinc-dihydromyricetin nano-enzyme in preparation of drugs for promoting healing of diabetic wounds, and the zinc-dihydromyricetin metal polyphenol nano-enzyme (Zn-DHM) is obtained by coordinating a metal element zinc (Zn) and a natural product dihydromyricetin (DHM) through a one-step method by taking PVP as a surfactant. The Zn-DHM nano-enzyme prepared by the invention has antioxidant property and cell proliferation and migration promoting ability, and can maintain metabolism and immune homeostasis of diabetic wounds, so that the Zn-DHM nano-enzyme can accelerate early healing of the diabetic wounds.

The invention belongs to the technical field of medicines, and particularly discloses application of moss phenol glucoside in preparation of medicines for preventing and / or treating tumors. According to the method, activated CD8 + T cells, MC38-OVA cells and traditional Chinese medicine monomeric compounds are co-cultured, the traditional Chinese medicine monomeric compounds capable of effectively promoting the anti-tumor activity of the CD8 + T cells are selected by utilizing a high-content screening technology, and finally, the experiment is carried out by taking the moss phenol glucoside as a research object. In-vitro experiment results show that the moss phenol glucoside can significantly promote T cell activation, promote release of cell factors such as IFN-gamma and TNF-alpha, and enhance the killing effect of T cells on tumors. A mouse in-vivo tumor-bearing experiment result shows that the moss phenol glucoside can promote the anti-tumor activity of T cells so as to inhibit tumor growth, has no obvious toxic or side effect, can be used for preparing the medicine for preventing and / or treating tumors, and has a potential clinical application prospect and a relatively high economic value.

The invention discloses a nanoimprint photoresist with high mechanical strength and high resolution and an ink-jet printing method of the nanoimprint photoresist. The nanoimprint photoresist is mainly designed for compatibility of ink-jet printing and nanoimprint technologies and high-precision manufacturing in the semiconductor field, after screening and blending, photoresist liquid drops can be distributed by an ink-jet printing head according to needs, required patterns can be rapidly printed, and the yield of the nanoimprint photoresist is improved. And finally, exposure is carried out through a nanoimprint lithography machine to realize 50 nm high-resolution imprint. Compared with the nanoimprint photoresist in the prior art, the nanoimprint photoresist disclosed by the invention has the advantages of rapid ink-jet printing, high curing rate, excellent anti-oxygen polymerization inhibition performance, high mechanical strength, high resolution, easiness in demolding and the like. The invention aims to improve the operability and the reliability of the nanoimprint photoresist in practical application, and has potential application prospects in the high-precision manufacturing fields such as advanced semiconductor manufacturing processes and the like.

The invention relates to the technical field of polyester resin, in particular to acrylic resin for a water-blocking film and a preparation method of the acrylic resin. The acrylic resin is a (styrene-acrylonitrile)-b-(flexible acrylic acid-functional monomer)-c-(styrene-acrylonitrile-silane coupling agent) block polymer; the block polymer comprises the following components in parts by mass: 20-70 parts of a flexible acrylic monomer; 5 to 25 parts of acrylonitrile; 20 to 50 parts of styrene; 1-7 parts of a silane coupling agent; 2-10 parts of a functional monomer, wherein the functional monomer is used for carrying out a cross-linking reaction with the curing agent; the (styrene-acrylonitrile)-b-(flexible acrylic acid-functional monomer)-c-(styrene-acrylonitrile-silane coupling agent) triblock polymer prepared in the invention has good heat resistance and certain elasticity, is acrylic resin with good binding force with a water-blocking coating, and is used for a polymer protective layer.

The invention relates to a preparation method of an antibacterial film. The preparation method comprises the following steps: preparing and forming an m-SiO2-SH-Ag-HA composite material; and blending the m-SiO2-SH-Ag-HA composite material into a membrane material, so as to form the antibacterial membrane. The hydrophilic HA in the antibacterial film formed by the preparation method can coat the outer side of m-SiO2-SH-Ag through electrostatic interaction to form an electrostatic barrier, effectively prevent the release of Ag < + > and play roles in stabilization, protection and slow release on one hand, and can increase the hydrophilicity of the surface of the film and effectively inhibit the early adhesion of bacteria on the other hand. When the target bacteria appear, HA coated on the surface of the m-SiO2-SH-Ag-HA is degraded by secreting hyaluronidase, so that the exposure and release of Ag < + > are promoted. The antibacterial film disclosed by the invention can release sterilization components through enzymatic initiation to realize on-demand antibiosis, and toxic and side effects and resource waste caused by uncontrollable continuous release of Ag < + > to the environment are avoided.

The invention belongs to the technical field of metal additive manufacturing, and relates to a preparation method of a large-size thin-wall structure based on magnetic field regulation and control of laser directional energy deposition. According to the method, the part forming area is filled with the protective gas, the oxygen content of the forming area is 100 ppm or below, and oxidation and inclusion pollution of alloy in the forming process are avoided. By starting the electromagnetic field generator, a stable uniform magnetic field is formed in a part forming area, the metallurgical behavior of a molten pool is regulated and controlled through the thermal damping effect and the thermal electromagnetic convection effect generated by the magnetic field in the molten pool, and optimization of the grain structure is achieved. A laser cladding head is started, powder metal materials are conveyed to the position of a molten pool through powder carrying gas, and the powder metal materials are molten through laser to form a stable molten pool; and a laser cladding head is controlled to scan in a uniform magnetic field area according to a set track to carry out circulating deposition, and light stopping is carried out every time deposition of one layer is completed, so that heat of a deposition layer is released, and heat accumulation is reduced until part forming is completed.

The invention belongs to the technical field of essential oil extraction, and discloses a tea essential oil extraction method which comprises a support, a distillation retort is fixedly mounted in the support through bolts, an air inlet pipe is welded to one end of the distillation retort, a condenser is connected to the top end of the distillation retort through a pipeline, and a collecting tank is mounted at one end of the condenser; a stir-frying mechanism is fixedly mounted in the distillation tank and comprises a screen for placing tea leaves, so that each part of the tea leaves can be uniformly heated in the distillation process, and the phenomenon of local overheating or insufficient heating is avoided, so that the quality and extraction efficiency of essential oil are ensured; compared with standing tea leaves, the stir-fried tea leaves can release more essential oil components in a short time, can promote air circulation, help molecules of the essential oil to be in better contact with steam and increase the volatility of the essential oil, so that the yield and the extraction efficiency of the essential oil are improved.

The invention discloses a flame-retardant fiber curtain fabric and a preparation method thereof, and relates to the technical field of flame-retardant fabrics, the flame-retardant fiber curtain fabric comprises a fabric substrate and a flame-retardant coating arranged on the fabric substrate, and the flame-retardant coating comprises nano-silica particles and nano-magnesium hydroxide particles in a mass ratio of 1: 1.2-2. The flame-retardant fiber curtain fabric prepared by the invention has remarkable flame retardance and thermal stability, and shows an excellent flame-retardant effect in a high-temperature environment.

The invention discloses functional injection type bionic hydrogel for promoting bone healing and a preparation method thereof, and relates to the technical field of medical instruments. The hydrogel has good functional characteristics, is a biomimetic material prepared on the basis of methacrylated gelatin, and aims to regulate and control the degradation rate, the drug release mechanism and diversified synergistic treatment and promote bone repair and regeneration; according to the hydrogel, matching of the degradation rate and the bone regeneration rate is achieved through reasonable matching, stem cell osteogenic differentiation and angiogenesis are promoted, ultrasonic controlled-release drug release and synergistic controlled-release of active factors are achieved, inflammation is reduced, and the bone repair process is promoted; the calcium phosphate bone cement provides biocompatibility and bone conductivity, and the nano clay releases active ions to improve the microenvironment and promote bone repair; in addition, the magnetic nanoparticles and a static magnetic field have synergistic interaction, the bone healing process is further accelerated, and treatment effect monitoring is enhanced through magnetic resonance imaging.

The invention relates to the field of medical patches, and discloses a controlled-release long-acting fever cooling patch which comprises a temperature response type material layer located on the outermost side of the fever cooling patch and used for triggering rapid release of medicine when the body temperature rises; the medicine composite layer is located on the inner side of the temperature response type material layer and used for compounding the antipyretic medicine and the traditional Chinese medicine ingredients together through a carrier, providing stable release of the medicine and enhancing the medicine effect; the invention also discloses a preparation method of the controlled-release long-acting fever cooling patch, which comprises the following steps: preparing the temperature response type material layer, dissolving the poly (N-isopropylacrylamide) or the copolymer thereof in a proper amount of solvent, coating the surface of the patch substrate with the solution, and drying to obtain the temperature response type material layer. The multi-layer composite structure is combined with the temperature and humidity response type material, so that the sustained release and long-acting antipyretic effect of the medicine are realized, the medicine release rate is automatically adjusted, the lasting and stable antipyretic effect is ensured, the medicine waste is reduced, and the convenience and comfort are improved.

The present invention relates to the technical field of medical devices, and in particular to a cystoscope capable of accurately locating the position of a double-J tube, comprising a handle portion and a mirror body portion, a clamp channel being arranged in the mirror body portion, the mirror body portion comprising an operating section and a main mirror tube section, an imaging system for photographing images being arranged at the end of the operating section; a tube clamping assembly is also arranged in the operating section, the tube clamping assembly comprises a limit plate and a push component, the limit plate is connected to the push component, and the clamp channel is arranged above the limit plate; a limit card slot is also arranged along the central axis of the limit plate, baffles are also arranged on both sides of the limit card slot body, and the double-J tube can pass through the baffles. In the removal operation of the double-J tube, when the double-J tube passes through the baffle, the mirror body portion is pulled backward, and in this process, the length of the double-J tube above the limit plate is gradually shortened, the originally curled end of the double-J tube can be gradually stretched, and the end of the double-J tube can be exposed on the surface of the limit plate, thereby improving the convenience of removing the double-J tube.

The invention provides organic nanoparticles with high osteogenic performance as well as a preparation method and application thereof, and belongs to the technical field of osteogenic drug preparation. The preparation method of the organic nanoparticles with high osteogenic performance comprises the following steps: (1) preparing fluorinated polyethyleneimine, preparing double bonds from the fluorinated polyethyleneimine, and then grafting a targeting peptide E7 to obtain a carrier F-PEI-E7; and (2) entrapping an osteogenesis promoting drug in the carrier F-PEI-E7 to obtain the organic nanoparticles with high osteogenesis performance. The invention provides an innovative strategy: F-PEI is used as a carrier, an osteogenesis promoting drug (beta-GP) is entrapped, and through E7 targeting peptide (EPLQLKM) modification, precise targeting delivery of the drug is realized. The organic nanoparticles are high in stability, the in-vitro osteogenesis promoting effect is equivalent to that of a classical formula for in-vitro osteogenesis induction, and the organic nanoparticles have an excellent in-vivo osteogenesis promoting effect.

The invention discloses an assembly type cable laying device which comprises a supporting table and a supporting mechanism, the supporting mechanism comprises a first transverse pipe, a segmented independent control type electric telescopic rod, a vertical supporting rod, a third transverse pipe and a clamping ring, the vertical supporting rod of the supporting mechanism is installed on the supporting table, and the upper end of the vertical supporting rod is connected with the first transverse pipe; a segmented independent control type electric telescopic rod is installed at one end of the first transverse pipe and comprises a first output mechanism and a second output mechanism, the first output mechanism is connected with a third transverse pipe in the output direction, the third transverse pipe penetrates out of the first transverse pipe to be connected with a clamping ring, and the output end of the first output mechanism is provided with a second output mechanism. The second output mechanism is in spiral transmission connection with the inner wall of the third transverse pipe. The first output mechanism of the segmented independent control type electric telescopic rod drives the clamping ring to abut against the inner wall of the cable drum, the cable drum is clamped and fixed, and meanwhile the second output mechanism of the segmented independent control type electric telescopic rod drives the cable drum to rotate.