368 results about "Neurotransmitter" patented technology

The invention belongs to the technical field of food microorganisms, and relates to lactobacillus plantarum and application thereof in preparation of products for relieving insomnia. The preservation number of the lactobacillus plantarum is GDMCC No: 65061. The lactobacillus plantarum can be applied to efficient fermentation of spina date seed juice, the content of GABA, polypeptide, total phenols and total flavonoids in the spina date seed juice is increased, and the content of spinosin, 6 ''-feruloyl spinosin, jujuboside A, jujuboside B and betulinic acid is increased; the reduction of whole brain coefficient and the increase of liver coefficient caused by long-term insomnia are relieved, the bad condition caused by long-term insomnia in a hippocampus DG region in the brain of the mouse is improved, the sleep time of the mouse is prolonged, and the insomnia symptom of the mouse is relieved; the content of inhibitory neurotransmitters 5-hydroxytryptamine, melatonin and gamma-aminobutyric acid in the hypothalamus of the mouse is increased, the content of excitatory neurotransmitter glutamic acid is reduced, and the reduction of organism immunity and oxidative stress of brain tissues caused by insomnia are relieved.

The invention belongs to the field of skin care products, and particularly relates to an anti-wrinkle and anti-aging composition as well as a preparation method and application thereof, and the anti-wrinkle and anti-aging composition comprises neurotransmitter inhibition peptide, signal peptide, madecassoside, inositol and glycosylglycerol. The neurotransmitter inhibition type peptide is at least three of acetyl hexapeptide-8, arginine / lysine polypeptide, dipeptide diaminobutyrylbenzylamide diacetate and acetyl octapeptide-3, and the signal type peptide is at least two of palmitoyl pentapeptide-4, decapeptide-4 and acetyl tetrapeptide-9. Compared with the prior art, all the components of the anti-wrinkle and anti-aging composition act on different anti-aging pathways and can be matched with one another from multiple aspects of oxidation resistance, inflammation resistance, moisturizing, cell viability enhancement, wrinkle reduction and the like, a more comprehensive and better anti-aging effect is provided, skin aging is comprehensively resisted, the skin is in a more young state, and the anti-wrinkle and anti-aging composition has the advantages that the anti-wrinkle and anti-aging effects are achieved. And the anti-wrinkle and anti-aging composition is small in irritation and good in stability.

The invention discloses a compound composition for improving sleep disorders, which is characterized by comprising the following components: an inhibitory neurotransmitter component, melatonin and a nano-lipid carrier, the nano-lipid carrier comprises phospholipid and cholesterol, the weight ratio of phospholipid to cholesterol is (1-6): 1, the weight ratio of phospholipid to cholesterol is (1-6): 1, and the weight ratio of melatonin to cholesterol is (1-6): 1. The inhibitory neurotransmitter component is wrapped in the nano-lipid carrier to form lipid nanoparticles, and the weight ratio of the inhibitory neurotransmitter component to the nano-lipid carrier is 1: (1-15). The compound composition can be prepared into a compound oral mucosa preparation, can be rapidly disintegrated when encountering saliva in the oral cavity, is good in patient compliance and small in side effect, all the components play a synergistic effect from different mechanisms through multiple target points, and the compound oral mucosa preparation can improve the sleep quality, prolong the sleep time and shorten the sleep latency; and patients with sleep disorders are helped to improve insomnia from the pathologic root.

A soaking device and methods of using are used to cool and / or to heat a face of a person for a purpose of inducing a desired and / or intended outcome in that person. The cooling and / or the heating of the face may be sufficient to induce the desired and / or the intended outcome in that person. The desired and / or intended outcome may relate to: release of at least one type of neurotransmitter; trigeminal nerve stimulation; (indirect) vagus nerve stimulation; transdermal drug delivery; bypass of the blood-brain-barrier (BBB); aesthetic medicine; cardiovascular; dermatological; ears, nose, and throat (otolaryngological); ophthalmological; neurological; psychological; endocrinological; and / or rheumatological benefits to that person. At least one step of the method may include receiving at least some of the face within an immersion-liquid for at least a minimum amount of time while the immersion-liquid is within a temperature-range and while the immersion-liquid is within the soaking device.

The invention relates to the technical field of active peptides, in particular to an active peptide composition and application thereof in preparation of anti-aging and wrinkle-removing products. The composition provided by the invention comprises the neurotransmitter regulating peptide and the signal peptide, and the components are properly selected, so that the composition can play a better role in anti-aging and anti-wrinkle aspects. In addition, the oil-soluble wrapped anti-aging and anti-wrinkle composition prepared by the invention aims to be quickly absorbed through skin, and the utilization rate of the active polypeptide is effectively improved.

A peripheral nerve stimulator to stimulate a peripheral nerve to treat essential tremor and other movement disorders, as well as overactive bladder, cardiac dysfunction and neurotransmitter dysfunction is provided. The peripheral nerve stimulator can be a noninvasive surface stimulator to provide multi-modal optimized therapy. Stimulation can be vibrational, electromechanical, thermal, radiant, electrical, magnetic, electromagnetic, light, mechanical, chemical, thermal, ultrasonic, radiofrequency (RF), acoustic, infrared, ultraviolet, x-ray, and / or microwave. Stimulation can be delivered using an open loop system and / or a closed loop system with feedback. Stimulation can be to one site or multiple sites.

The invention belongs to the technical field of bioengineering, and discloses a sunflower seed peptide for regulating metabolism of brain cells, the sunflower seed peptide has a biological sequence of Arg His Ala Lys Thr Pro Ser Asn Lys, and a preparation method of the sunflower seed peptide for regulating metabolism of brain cells comprises the following specific steps: S1, raw material pretreatment; s2, peeling and crushing; s3, protein extraction; s4, performing enzymolysis treatment; s5, performing enzyme deactivation treatment; s6, filtering and purifying; s7, concentrating and drying; and S8, quality detection and packaging. The sunflower seed protein is directionally decomposed into the active peptide fragment by precisely regulating and controlling compound protease and enzymolysis conditions, the active peptide fragment can be compatible with a brain cell specific receptor and penetrate through a blood brain barrier, and cell experiments and animal models prove that the peptide fragment can activate a mitochondrial respiratory chain complex, so that the mitochondrial membrane potential is increased by more than 30%, and the mitochondrial membrane potential is increased by more than 30%. Meanwhile, the activity of neurotransmitter synthetase can be enhanced, the brain health is protected, and tests further prove that the sunflower seed peptide also has the function of regulating the metabolism of brain cells.

The present invention discloses a class of bicyclic peptide compounds and their applications, belonging to the technical field of bicyclic peptide compounds. Specifically, the invention relates to the preparation of a fully protected peptide resin using solid-phase synthesis; cleavage and monocyclic cyclization of the fully protected peptide resin to obtain a monocyclic polypeptide; and dicyclic cyclization of the monocyclic polypeptide to obtain a bicyclic peptide compound, wherein the dicyclic cyclization is carried out under the action of iodine methanol and ascorbic acid. The bicyclic peptide compound prepared by the present invention has the following beneficial effects: good safety, low cytotoxicity, good stability, slow degradation rate, good effect on enhancing collagen expression, good effect on enhancing elastin expression, and good effect on inhibiting neurotransmitter release.

The invention relates to the technical field of medical data processing and nerve regulation and control, in particular to a method for synchronously activating post-stroke neuroplasticity through photoacoustic, which comprises the following steps of: 1, constructing a stroke specific brain region target map: fusing brain structure connection data and functional network data of a patient, generating a three-dimensional target map containing the high-metabolism semi-dark band coordinate set and the cross-hemisphere compensatory connection intersection; 2, calculating a time-space synchronization focusing parameter; 3, synchronous stimulation and dynamic regulation are executed, wherein the ultrasonic transducer and the laser source are controlled to emit time-space synchronous sound waves and light pulses; monitoring the blood perfusion variable quantity and the neurotransmitter concentration ratio of the target brain area in real time; when the blood perfusion variable quantity does not reach the expectation or the transmitter ratio is unbalanced, the stimulation intensity is dynamically adjusted, and the focusing coordinate is translated in the direction away from the infarction area. Through photoacoustic stimulation of time-space synchronization, the difference between the propagation speeds of sound waves and light waves is overcome, and accurate collaboration of neural restoration is achieved.

The invention belongs to the technical field of microorganisms, and relates to lactobacillus acidophilus LA4 and application thereof. The classification name of the lactobacillus acidophilus LA4 is lactobacillus acidophilus, the lactobacillus acidophilus LA4 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on July 9, 2025, and the preservation number of the lactobacillus acidophilus LA4 is CGMCC No.35144; the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The strain can significantly improve cognitive impairment of an elderly behavior cognitive impairment model mouse and enhance the learning and memory ability of the mouse by reducing deposition of beta amyloid protein in the brain of the mouse, inhibiting the activity of acetylcholin esterase, regulating and controlling the neurotransmitter level, relieving brain inflammatory response, reducing nerve injury, promoting synaptic regeneration and the like. The strain provided by the invention provides a potential treatment scheme for preventing or improving senile behavioral cognitive impairment, and has important development and application values.

The invention discloses a plant lactobacillus and application thereof in preparation of gamma-aminobutyric acid and improvement of sleep, and relates to the technical field of biology. According to the present invention, the plant lactobacillus XBMU-SN-23 has been preserved in the China General Microbiological Culture Collection Center (CGMCC) on December 19, 2025, and the preservation number is CGMCC No.37118. The present invention further provides applications of the plant lactobacillus XBMU-SN-23 in gamma-aminobutyric acid preparation and sleep improvement. A metabolite of the strain XBMU-SN-23 has a sleep aiding function, and can regulate and control a neurotransmitter system to improve sleep quality by up-regulating GABA, 5-HT, IL-1 and MT, down-regulating Glu and DA and regulating protein quantity expression of a 5-HT1A receptor, a GABAAR alpha 1 receptor and a GABAAR gamma 2 receptor. Therefore, the plant lactobacillus XBMU-SN-23 has a wide application prospect in the product for preventing or treating insomnia.

The invention discloses lactobacillus paracasei CFCFC018, a microbial agent and application of the lactobacillus paracasei CFCFC018, and belongs to the technical field of microorganisms. The lactobacillus paracasei CFCFC018 is separated from intestinal contents of rural cats in half-farming and half-pastoral areas in Inner Mongolia, does not need genetic engineering modification, can highly express amino acids and neurotransmitters, can remarkably relieve mammary gland alveolar structure damage in mammary gland tissues of rats suffering from mastitis induced by staphylococcus aureus, and has the advantages of being high in safety and good in stability. The thickening of a mammary gland interacellular matrix layer is avoided, the infiltration number of neutrophils is reduced, the damage degree of mammary gland tissues is reduced, and a certain protection effect on the mammary gland tissues is achieved. The research also shows that the strain can reduce the abundance of harmful bacteria in excrement, improve intestinal inflammation and relieve edema of intestinal submucosa, which provides a new thought for preventing and treating mastitis by regulating intestinal microbiota.

The invention discloses a composition for treating depression and application of the composition. The composition for treating depression is prepared from the following components in parts by weight: 35 to 40 parts of ligustilide, 0.5 to 1.5 parts of atractydin and 0.1 to 1 part of alpha-cyperone. According to the invention, the active components in the Yueju pill, which are targeted to 5-HT1AR and 5-HTT, are compounded for the first time to prepare a new traditional Chinese medicine functional component composition, and in addition, the anti-depression effect of the active components is evaluated by establishing a reserpine mouse depression model, so that the anti-depression effect of the Yueju pill is improved. The result shows that the active component composition screened by the 5-HT1AR and 5-HTT targets can adjust the content of monoamine neurotransmitters in brain tissues in vivo to achieve the anti-depression effect, and in-vivo pharmacological experiments fully prove that the composition has the anti-depression effect.

The invention relates to a method and a device for mapping a cortical nerve image marker in a neurotransmitter map, which can be used for exploring abnormal modes of cortical structures and functions of SCA patients, carrying out functional annotation on the anomalies and analyzing the association between the anomalies and a specific biological process. The method comprises the following steps: (1) obtaining 3D-FSPGR and GRE-SS-EPI sequences; (2) preprocessing image data; (3) image feature extraction: dividing a cortex region through a network function partition map; in order to evaluate the difference between the groups, a t graph of each feature is calculated based on a generalized linear model (GLM), and the t graph comprises the cortex thickness, the brain sulcus depth, the curvature, the ALFF and the ReHo; the model takes gender, age and total cranial volume as covariables so as to control potential confounding factors; and (4) associating the Neuromaps annotation with the structural and functional characteristics.

The invention provides a sleep-promoting grease composition as well as a preparation method and application thereof, and relates to the technical field of edible oil. The grease composition comprises, by weight, 40-50 parts of grease and 45-60 parts of auxiliary materials, the grease comprises rice oil, hemp seed oil and spina date seed oil according to the weight ratio of (20-30): (10-15): (5-10), and the auxiliary materials comprise a filler, an emulsifier and an antioxidant. According to the grease composition, the sleep rate, the sleep time and the GABA neurotransmitter level are improved, so that sedative hypnosis and sleep promotion can be achieved, meanwhile, the preparation method is simple, and the stability is good.

The invention provides lactobacillus plantarum for regulating mood health and resisting depression and application thereof, and the strain is separated from traditional pickles and is identified as lactobacillus plantarum. Experiments show that KY013 can significantly improve behavioral performance of depression model mice, and the effect of KY013 is equivalent to that of fluoxetine. The action mechanism comprises the following steps: up-regulating the levels of neurotransmitters such as 5-HT, DA, NE and GABA in hypothalamus, regulating the balance of proinflammatory factors (IL-6 and IFN-alpha) and anti-inflammatory factors (IL-10), and playing an anti-depression role through'neurotransmitter-immunity 'double ways. The KY013 disclosed by the invention can be used for developing antidepressant drugs or functional foods and the like, has the advantages of multi-target coordination, high safety and the like, and provides a new microecological preparation choice for treating depression.

The invention discloses a beverage capable of improving sleep and a preparation method of the beverage, and belongs to the technical field of fermentation engineering technology and health-care food. Through a specific probiotic fermentation system, a natural raw material extracting solution, sodium glutamate and a humulus lupulus extract are jointly fermented, endogenous GABA is efficiently converted and generated, and the endogenous GABA and functional components such as pachymaran, lily polysaccharide and jujuboside form a polymorphic composite system. The GABA in the prepared beverage is high in bioavailability and good in stability, all the components have a synergistic effect through multiple ways such as intestinal brain axis regulation and neurotransmitter regulation, sleep is effectively improved, and meanwhile the beverage has good flavor and storage stability.

The invention provides a schizophrenia core epicenter region identification method based on a multi-mode nerve image, and belongs to the technical field of medical image analysis and neuropsychiatric disease diagnosis. According to the method, a macroscopic-mesoscopic-microscopic covariant network model is established by integrating multi-modal nerve image data (including structural magnetic resonance, functional magnetic resonance imaging and diffusion tensor imaging) and mesoscopic-microscopic scale data (gene expression atlas, neurotransmitter distribution and cell construction characteristics). The method comprises the following steps: firstly, constructing various connection networks, then identifying a core epicenter region with abnormal grey matter thickness based on a graph theory algorithm, carrying out cross-scale matching on the epicenter region and gene expression, neurotransmitter and cell structure characteristics by utilizing spatial correlation analysis, and analyzing a diffusion path of the epicenter region through connection omics. By fusing the multi-scale biomarkers, the limitation of single modal analysis is broken through, and systematic analysis of the schizophrenia pathological network is realized.

The invention discloses a composition with a sleep improving function as well as a preparation method and application thereof, and the composition is prepared from the following raw materials in parts by weight: 50-100 parts of acanthopanax root, 30-50 parts of lotus seed, 50-100 parts of spina date seed, 30 parts of lily, 30 parts of longan, 30-50 parts of poria cocos, 30 parts of radix ophiopogonis, 10-30 parts of rehmannia, 10-30 parts of gastrodia elata, 2 parts of glutamic acid, 0.1 part of vitamin B, 0.1 part of vitamin B6 and 0.1 part of gamma-aminobutyric acid. The traditional single target spot limitation is broken through, a synergistic effect system of tonifying the spleen and soothing the nerves-neurotransmitter regulation and control-intestinal brain axis regulation is formed, a buffer solution of pH simulation biological fluid is adopted as a non-organic extraction medium in the process, the ultrasonic cavitation effect and the plasma activation effect are combined, the temperature is controlled in the whole process, and the preparation method is simple and easy to implement. The problems of vortex, uneven extraction, dead volume, solvent residue, active ingredient damage and the like in traditional extraction are fundamentally solved, the composition capable of effectively improving the sleep quality is obtained, and animal model and crowd experiments prove that the composition can effectively improve the sleep quality and achieve a good sleep aiding effect.

The invention discloses a three-dimensional electric field vector detection and microdialysis synchronous sampling implanted probe system, and belongs to the technical field of neural electrophysiology detection. The system comprises a vector electric field detection module (containing multiple layers of platinum-iridium alloy contacts) and a microdialysis module (provided with a semi-permeable membrane window with high selectivity and biological compatibility) which are coaxially integrated, and spatial isolation and synchronous acquisition of electro-chemical signals are realized through an insulating support structure. The problems of separation and spatial dislocation of an electric field detection and biochemical sampling system in the prior art are solved, real-time association of three-dimensional electric field vector reconstruction and neurotransmitter analysis is supported, and accurate electro-chemical coupling data is provided for nerve regulation and control research.

The invention provides a pharmaceutical composition for treating Alzheimer's disease. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 10-15 parts of ginseng, 10-15 parts of rhizoma acori graminei, 10-15 parts of polygala tenuifolia, 15-20 parts of rhizoma polygonati, 15-20 parts of ginkgo leaves and 5-10 parts of schisandra chinensis. Therefore, the ginseng and the ginkgo leaves jointly regulate a cholinergic system and cerebral blood flow, and the cognitive function is enhanced; the rhizoma acori graminei and the ginkgo leaves cooperate to inhibit aggregation of beta-amyloid protein, improve cerebral circulation and relieve neurotoxicity. Polygonatum sibiricum and Chinese magnoliavine fruit protect nerve cells through anti-oxidation and anti-inflammatory effects and reduce nerve injury. Schizandrin further stabilizes a neurotransmitter system and enhances the synergistic effect of other medicinal materials, a multi-layer treatment network of Abeta deposition inhibition, cholinergic system regulation, anti-inflammation and anti-oxidation and nerve protection is integrally formed, and the core pathological link of the Alzheimer's disease is comprehensively intervened, so that the cognitive function is improved, and the disease progress is delayed.

The invention discloses a humanoid robot control method based on a neural circuit, and belongs to the technical field of robot control, and the method comprises the steps: S1, constructing a three-layer pulse neural control architecture comprising spinal cord reflex, brainstem balance and cortex decision, and carrying out the weight adaptive distribution and cooperative operation between layers through the dynamic adjustment of neurotransmitter concentration, organic cooperation of prediction and reflection is realized through a three-stage control system; the cerebellar prediction network executes attitude adjustment in advance through a delay compensation algorithm, and compared with pure feedback, the control energy consumption is reduced; the parallel reflex pathway of the spinal cord layer establishes a nerve bypass mechanism, and the emergency response is realized by bypassing high-level processing in an emergency; the multi-layer safety monitoring improves the triggering accuracy of a protection mechanism through error confidence evaluation and contact stability analysis; a weight transfer mechanism of pulse frequency modulation avoids sudden movement change during control mode switching; by means of the design, the stability retention rate of the robot walking on the inclined plane is remarkably improved compared with a traditional method.

The invention discloses a bicyclic peptide compound and application thereof, belongs to the technical field of bicyclic peptide compounds, and particularly relates to full-protection peptide resin prepared through solid-phase synthesis. Carrying out cutting and monocyclic cyclization on the full-protection peptide resin to obtain monocyclic polypeptide; the monocyclic polypeptide is subjected to binary cyclization treatment to obtain a bicyclic peptide compound, and the binary cyclization is cyclized under the action of iodinemethanol and ascorbic acid. The bicyclic peptide compound prepared by the invention has the beneficial effects of good safety, small cytotoxicity, good stability, slow degradation speed, good collagen expression improvement effect, good elastin expression improvement effect and good neurotransmitter release inhibition effect.

The invention provides a glass nanopore probe based on an aptamer and application of the glass nanopore probe in dopamine detection, and belongs to the technical field of electrochemical sensing and scanning probe microscopy. The sensor comprises: a glass nanopore probe, the inner wall of which is modified with a gold layer; a cDNA (complementary deoxyribonucleic acid) single chain is fixed on the gold layer through a gold-sulfur bond; a part of the sequence of the dopamine aptamer is hybridized and combined with the cDNA single chain; wherein the combination of the dopamine and the dopamine aptamer causes the change of an ion current rectification signal of the glass nanopore probe, so that the detection of the dopamine is realized based on the change of the ion current rectification signal of the glass nanopore probe. The invention provides a valuable scheme for developing an aptamer nanopore scanning electrochemical sensor for single cell analysis and researching neurotransmitter-related diseases.

The invention discloses application of lactobacillus rhamnosus to preparation of a product for improving and treating cognitive impairment. The invention discloses the new application of the rhamnosus cheese for the first time, and the rhamnosus cheese can improve or treat cognitive impairment related to aging by improving behavioral function change, brain inflammatory factors, oxidative stress activity and neurotransmitter level caused by aging of mice and regulating transcriptome, intestinal microbiome, metabolome and the like. The lactobacillus rhamnosus has a potential application prospect in the aspect of improving learning and memory ability impairment caused by senescence.

The invention provides a neurotransmitter-entrapped ginsenoside liposome and a preparation method thereof, the neurotransmitter-entrapped ginsenoside liposome is prepared from the following raw materials: ginsenoside, neutral phospholipid and acetylcholine, and the mass ratio of ginsenoside to neutral phospholipid to acetylcholine is (6-10): (10-20): (10-15). The lipidosome can effectively inhibit intestinal inflammation reaction, relieve intestinal inflammation damage, repair damaged ENS and improve intestinal functions, is suitable for being used as a treatment or adjuvant treatment mode of IBD, especially for regulation and control of an intestinal mucosa immune system of an IBD patient and protection and repair effects on nerves, improves treatment targeting, and has a good application prospect. The preparation method is simple and convenient, high in safety and excellent in economic benefit and social benefit.

The invention belongs to the technical field of probiotics, and particularly relates to a probiotic composition capable of improving emotion and a preparation method and application of the probiotic composition capable of improving emotion. The composition comprises bifidobacterium pseudolongum, Adellomyces aldelii, microbacter cecum, streptococcus thermophilus, Ackermann mucophilus and intestinal pasteurella, and the probiotic composition capable of improving emotion and the preparation method and application of the probiotic composition capable of improving emotion and the preparation method and application of the probiotic composition capable of improving emotion and the probiotic composition capable of improving emotion and the probiotic composition capable of improving emotion and the probiotic composition capable of improving emotion. The obtained probiotic composition has a remarkable improvement effect on animal depression and anxiety behaviors caused by chronic social contusion stress, and the technical problem that in the prior art, depression drugs cannot target intestinal flora metabolite regulation and accurate intervention of neurotransmitter balance at the same time is solved. The probiotic composition can quickly and enduringly improve depression and anxiety behaviors caused by chronic stress, has better safety, and can be used for preventing and treating depression and related mental diseases thereof.

The invention discloses bifidobacterium longum subsp. Infantis for regulating intestinal motility and aquaporin and application of the bifidobacterium longum subsp. Infantis, and belongs to the technical field of microorganisms. According to the invention, the bifidobacterium longum subsp. Infantis CCFM1269 is screened, and the bifidobacterium longum subsp. Infantis CCFM1269 has the effects of intestinal motility and aquaporin, specifically, the defecation frequency is reduced, and the water content of excrement and the small intestine propulsion rate are reduced. The intestinal motility abnormality is relieved by reducing the levels of neurotransmitters 5-HT, SP and VIP, and the intestinal moisture absorption and secretion are regulated by improving the mRNA expression of aquaporin AQP4 and AQP8. Meanwhile, the intestinal flora is adjusted by improving the diversity of the intestinal flora, and the content of propionic acid and butyric acid in excrement is increased.

The invention discloses a herbal medicine composition and application thereof. The herbal medicine composition comprises the following components in percentage by mass: 5%-85% of an extract of Indian ginseng, 5%-85% of an extract of rhodiola rosea, 5%-85% of an extract of melissa officinalis and 5%-85% of an extract of holy basil. The herbal composition is a natural composition that effectively supports mental health while minimizing adverse effects and promoting overall health; in particular, the herbal composition can achieve effects including "coordinated regulation of multiple neurotransmitter systems", "multi-target regulation of an HPA axis", "coordinated enhancement of an antioxidant system", "coordinated promotion of neuronutrition and neuroplasticity", "a synergistic effect of inflammation regulation", and "a synergistic effect of gene expression regulation".

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of drugs for improving sleep disorder and treating mood disorder or cognitive disorder. The invention provides a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components in parts by mass: 20-30 parts of lycium ruthenicum, 30-40 parts of nitraria fruit, 15-25 parts of gastrodia elata, 13-25 parts of hyperforin perforatum and 2-6 parts of lycopene. The traditional Chinese medicine composition provided by the invention is prepared from lycium ruthenicum, nitraria fruit, gastrodia elata, hyperforin perforatum and lycopene according to a specific ratio, and the composition can effectively relieve anxiety behaviors of chronic stress bound anxiety model mice through ways of resisting oxidation and inflammation, regulating expression of neurotransmitters and the like, prolong sleep time and improve sleep quality. The learning ability and the memory ability of cognitive impairment mice induced by scopolamine are improved, and the neuron density of brain tissues is increased, so that the neuroprotective effect is achieved.