47 results about "Neurotransmitter" patented technology

The application relates to an LC-MS / MS method for detecting neurotransmitter metabolites in a biological sample, comprising the following steps: S1, constructing a mass spectrum database containing neurotransmitter metabolites and isotope internal standards; S2, preparing a mixed standard solution containing neurotransmitter standards and drawing standard curves of each neurotransmitter metabolite standard; S3, extracting a biological sample by a protein precipitation method to obtain a sample solution to be detected; S4, separating the sample solution to be detected by using liquid chromatography, wherein a mobile phase A of the liquid chromatography is an aqueous solution containing ammonium fluoride and formic acid, and a mobile phase B is an organic phase containing formic acid; and S5, performing mass spectrum detection on the sample separated by the liquid chromatography. The method can realize baseline separation of 57 metabolites within 9 minutes.

This invention discloses a sleep-aid composition that synergistically regulates sleep rhythm with 5-HTP and L-theanine, relating to the fields of biomedicine and health food technology. This invention effectively regulates sleep rhythm through the synergistic effect of 5-hydroxytryptophan, L-theanine, and γ-aminobutyric acid (GABA), helping users improve sleep quality. 5-HTP, as a precursor to serotonin, helps increase serotonin levels, which are then converted into melatonin, regulating the sleep cycle. L-theanine promotes the release of alpha brain waves, helping to relax the mind and body and reduce anxiety. GABA, as an inhibitory neurotransmitter, effectively relieves tension and promotes deep sleep. The synergistic effect of these three components provides users with more comprehensive and effective sleep support.

Techniques for measuring single synaptic signals under varying experimental conditions include controlling a video recording microscope to capture, at multiple different times, a first imaged area in a sample holder as a video frame when the sample holder is disposed on a stage and holds a sample of neuronal tissue combined with at least one fluorophore that emits a corresponding electromagnetic wavelength in a synapse during synaptic activity. At least one synaptic region of interest is determined based on a group of pixels in the first imaged area that record electromagnetic emissions from the fluorophore at the different times. An ordered time series of emission intensity is recorded in each of the synaptic region of interest. Peak emission intensity values in the time series are corrected for transmitter label transients. The ordered time series with corrected peak emission intensity values are stored in a data structure with a standard format.

This invention discloses a neurotrophic brain protein peptide composition and its applications, belonging to the field of food technology. The components of the composition provided by this invention have synergistic effects. On the one hand, they reduce the damage of oxidative stress to the nervous system, improve sleep quality, and create a favorable environment for the repair and regeneration of the nervous system. On the other hand, they provide the raw materials needed for the maintenance, repair, and regeneration of nerve cells, as well as the synthesis of neurotransmitters, ensuring energy supply and the activity of the required enzyme systems, thereby achieving the effect of effectively nourishing / repairing nerves and / or promoting nerve regeneration. The provided composition does not use organic reagents, is environmentally friendly, and has high safety; it has low preparation cost and a good taste.

The purpose of the present disclosure is to provide a novel plant environmental stress alleviator, a plant growth promoter, and a plant DNA repair promoter that have an excellent effect of alleviating environmental stresses such as high temperatures.　The present disclosure provides a plant environmental stress alleviator, a plant growth promoter, and a plant DNA repair promoter containing: one or more neurotransmitters selected from choline esters, catecholamines, serotonin, and amino acids, and / or one or more acetylcholinesterase inhibitors selected from polyphenols, flavonoids, and organic acids, or a plant extract containing said inhibitors; and calcium ions. The present disclosure also provides a method for producing the aforementioned agents.

The application discloses application of SCAMP5 in treatment of autism spectrum disorder. The application research proves that, compared with a CON group, VPA-induced ASD rats have significant neurotransmitter release disorder and synapse signal path abnormality in hippocampus, overexpression of SCAMP5 protein can improve abnormal release of Glu, abnormal expression of scaffold protein Homer1b / c and downstream protein IP3R, and meanwhile, can relieve autism-like behaviors, space working memory and synapse development abnormality of ASD rats. The application provides a new target and a new potential drug for treatment of autism spectrum disorder, and provides a new idea for target treatment of ASD by in-depth exploration of potential path in pathogenesis of autism.

The application discloses a kind of neurotransmitter classification method, system, equipment and medium, wherein the method obtains the target feature data of target neurotransmitter, and the first classification weight corresponding to the trained feature classification model and the second classification weight corresponding to the trained sequence classification model;The target feature data is input into the trained feature classification model to carry out prediction classification, and obtain first prediction classification vector;The target feature data is input into the trained sequence classification model to carry out prediction classification, and obtain second prediction classification vector;According to the first classification weight and the first prediction classification vector, the second classification weight and the second prediction classification vector are classified and fused, and the classification result of the target neurotransmitter is obtained.The method can effectively improve the accuracy of neurotransmitter classification.The application relates to the field of machine learning technology.

The application relates to the technical field of medicines, in particular to application of glycyrrhiza chalcone A in preparation of medicines for treating depression. The application experiment shows that the glycyrrhiza chalcone A can significantly improve the CUMS-induced depression-like behavior of mice, reduce the hippocampal neuron damage, inhibit the neuroinflammatory reaction, and restore the 5-HT level, and the anti-depression mechanism may be closely related to multiple mechanisms such as down-regulation of MAPK / JNK path activity, inhibition of inflammatory factor expression and neurotransmitter regulation.

This invention discloses a DNA nanochannel-engineered nanofluidic synapse, its preparation method, and its application. The synapse comprises a solid nanochannel substrate, a phospholipid multilayer membrane, and a programmable DNA nanochannel. The phospholipid multilayer membrane is grown in situ on the surface of the solid nanochannel substrate. The DNA nanochannel is embedded in the phospholipid multilayer membrane through hydrophobic interactions between the hydrophobic tails of cholesterol and phospholipids. A locker specifically for capturing neurotransmitters is disposed at the top of the programmable DNA nanochannel. This invention's DNA nanochannel-engineered nanofluidic synapse, by introducing an AAO substrate (providing mechanical stability and integration) and a phospholipid multilayer membrane (providing a biomimetic environment, interference resistance, and signal amplification), elevates pure DNA nanochannel gating technology from a "fragile and low-sensitivity" state to a "robust and highly sensitive" engineered device.

The present invention discloses a sleep-aid composition for synergistically regulating the sleep rhythm with 5-HTP and L-theanine, relating to the technical field of biomedicine and health foods. Through the synergistic action of 5-hydroxytryptophan, L-theanine, and gamma-aminobutyric acid, the present invention effectively regulates the sleep rhythm and helps users improve sleep quality. As a precursor of serotonin, 5-HTP helps increase the serotonin level and is then converted into melatonin to regulate the sleep cycle. L-theanine promotes the release of alpha brain waves to help relax the body and mind and reduce anxiety. As an inhibitory neurotransmitter, GABA can effectively relieve tension and promote deep sleep. The three components act synergistically to provide users with more comprehensive and more effective sleep support.

The application relates to the technical field of medicines, and discloses application of a traditional Chinese medicine composition in serum neurotransmitters, which comprises the following steps: selecting 6-8-week-old mice to establish normal models, chronic fatigue syndrome models and functional dyspepsia models; blood sampling is conducted on the mice of the normal models, the chronic fatigue syndrome models and the functional dyspepsia models to obtain normal blood samples, CFS blood samples and FD blood samples respectively; protein precipitation operation is conducted to obtain normal deproteinized supernatants, CFS deproteinized supernatants and FD deproteinized supernatants; separation is conducted by using a reversed-phase chromatographic column, and then mass spectrometry is conducted to obtain normal serum neurotransmitter mass spectra, CFS serum neurotransmitter mass spectra and FD serum neurotransmitter mass spectra respectively; concentration value calculation and rhythm fluctuation analysis are conducted to obtain a neurotransmitter function index and rhythm stability quantitative score respectively. Therefore, the mechanism of the traditional Chinese medicine composition in serum neurotransmitters is clearly quantitatively characterized.

This invention discloses a plant essential oil spray with anti-anxiety and antidepressant effects and its preparation process, available in daytime and nighttime versions. The plant essential oil mixture is prepared by coupled flash extraction with anhydrous ethanol and 1-octyl-3-methylimidazolium bromide, followed by microfiltration-nanofiltration and vacuum distillation. The excipients and essential oils are then mixed and bottled into spray bottles equipped with an automatic spraying device to obtain the daytime and nighttime plant essential oil sprays. The daytime version stimulates the autonomic nervous system, reduces mental fatigue, improves cognitive mood, and exerts an anti-anxiety effect during the day; the nighttime version regulates neurotransmitter levels, significantly calms and soothes the mind, and adapts to the differences in human mood and nervous state between day and night. This invention features high extraction efficiency, stable essential oil quality, and the product possesses both anti-anxiety and antidepressant effects. It is convenient to use, highly safe, and suitable for daily mood regulation, psychological stress relief, and intervention for anxiety and depression tendencies.

The present application relates to a kind of pentosus PP90 for preventing and treating alcoholic nerve injury and its application, wherein pentosus PP90 is preserved in China Microbial Culture Collection Center, and the preservation number is CGMCC NO.32034.The fermentation product of the pentosus PP90 can degrade the alcoholicity of alcohol, can produce ethanol dehydrogenase and acetaldehyde dehydrogenase, can improve the viability of nerve cell, can regulate the expression of cytokine, can inhibit the activation of astrocyte, can regulate the expression of brain-derived neurotrophic factor, can improve the level of disturbed neurotransmitter, and can be used for preparing product for preventing and treating alcoholic nerve injury or improving alcoholic nerve injury.

The application discloses a pet nutrition composition based on intestinal-brain axis regulation and application thereof, and the composition comprises 5-20% of probiotics, 10-25% of prebiotics, 2-10% of neurotransmitter precursors, 5-15% of anti-inflammatory and neurotrophic factors, 1-10% of plant extracts and the rest of carriers. The application remolds intestinal microecology by the synergy of probiotics and prebiotics, promotes the synthesis of 5-hydroxytryptamine and dopamine by neurotransmitter precursors, exerts the neuroprotective and anti-inflammatory effects by omega-3 fatty acids, vitamin B group and magnesium elements, realizes the anti-anxiety and tranquilizing effects by L-theanine, chamomile and lavender extracts, and forms a regulation link of multi-target point synergistic intervention of intestinal-brain axis. According to animal experiment verification, the application can significantly improve the anxiety behavior of pets, improve the content of fecal short-chain fatty acids, remodel the intestinal flora structure, and realize the synergistic effect of 'intestinal health-nerve regulation-behavior improvement'.

This invention provides a flexible, foldable, multifunctional clinical neural probe and its fabrication method, relating to the field of clinical neurophysiological signal and neurotransmitter detection sensors. The neural probe includes a folded portion, which comprises a base layer, a conductive layer, and an insulating layer stacked sequentially. The conductive layer includes multiple parallel signal detection units, each comprising: a detection site formed at the head end of the folded portion; a pad formed at the tail end of the folded portion; and a first lead wire arranged along the neural probe and connecting the detection site and the pad. The first lead wire includes at least two first lead wire segments and at least one second lead wire segment on the same plane. Each first lead wire segment is a straight line segment, and each end of each second lead wire segment is connected to a first lead wire segment. Two first lead wire segments connected to the same second lead wire segment can be unfolded or folded around the second lead wire segment, and when both first lead wire segments are unfolded, they are on the same straight line.

This invention relates to nutritional compositions and their uses. Specifically, this invention relates to a nutritional composition comprising: (1) component A consisting of docosahexaenoic acid and arachidonic acid; (2) component B consisting of medium- and long-chain fatty acid triglycerides and 1,3-dioleoyl-2-palmitoyl triglycerides; and (3) component C consisting of choline and taurine. This invention also relates to the use of this nutritional composition for non-therapeutic purposes, including: promoting neurotransmitter expression; improving neuronal structure and function; and improving anxiety. This invention further relates to the use of this nutritional composition in the preparation of products for non-therapeutic purposes, including improving brain development and / or memory and / or improving anxiety. The nutritional composition of this invention can significantly improve brain development and / or memory and / or improve anxiety, which is beneficial for meeting current market demands.

This invention discloses a *Ligilactobacillus salivarius* YS-SA09, with accession number CGMCC NO.37763 and Latin name *Ligilactobacillus salivarius*. This invention also discloses a *Citrus aurantium* ferment, obtained by fermenting *Citrus aurantium* with the aforementioned *Ligilactobacillus salivarius* YS-SA09. This invention further discloses the applications of *Ligilactobacillus salivarius* YS-SA09 and the *Citrus aurantium* ferment, which can effectively improve sleep in mice with insomnia models, effectively shorten sleep latency, and prolong sleep onset time; effectively improve depressive-like behavior in mice with CUMS models; significantly reverse the decrease in neurotransmitter levels caused by CUMS in mice, effectively increase the levels of GABA, 5-HT, DA, and NE in the serum of depressed mice; reduce serum TNF-α and IL-6 levels, and improve inflammatory factor levels.

This invention relates to the field of bioactive peptide technology, and discloses a tetrapeptide with cognitive-improving function and its applications. The primary amino acid sequence of the tetrapeptide is Lys-Gly-Phe-Pro, and its molecular weight is 489.2587 Da. The tetrapeptide of this invention can be chemically synthesized or directionally prepared from sea cucumber protease hydrolysates. The tetrapeptide of this invention exhibits cognitive-improving activity, mainly through inhibiting GABA. B The expression of R activates the cAMP / PKA / CREB signaling pathway, promotes the release of the inhibitory neurotransmitter GABA, reduces oxidative stress damage, increases the gene expression of neurotrophic factors Bdnf and Nt3, and significantly upregulates the gene expression of antioxidant enzymes Sod1 and Gpx1, thereby exerting a neuroprotective effect and improving age-induced cognitive impairment.

Disclosed is an ActiOmega® composition (unsaturated fatty acids and phospholipids) comprising Bacopa monnieri extracts. The composition in the present invention can improve concentration, enhance cognition, improve learning and memory abilities, increase the release and transmission rate of neurotransmitters, enhance hippocampal activity, promote the absorption and utilization of DHA in the human body and the brain development. The DHA in the present invention achieves efficient purification and impurity removal through ultra-high vacuum molecular distillation technology (without the need for solvents), and ensures almost no fishy odourthrough the high vacuum steam deodorization process, with higher DHA content and purity, natural green colour, easy access to the brain, and high bioavailability.

This application belongs to the field of emotion monitoring technology, and provides a method and system for emotion monitoring and intervention based on multimodal neurochemical sensing. It acquires electroacoustic and optical fluorescence spectral signals from a user's target tissue region through a wearable device, and identifies neurotransmitter system activity information through signal fusion and decoding. This information is then input into an individualized dynamic emotion monitoring model to obtain the user's current emotional state type and intensity. Combining these two indicators, an emotion instability index is calculated in real time. When the index exceeds an individualized critical threshold, a personalized intervention plan matching the instability characteristics is generated and executed. The critical threshold can also be dynamically adjusted based on the intervention effect and real-time physiological state. This invention achieves non-invasive neurotransmitter monitoring and emotion monitoring, assessment, and intervention, improving monitoring accuracy and the timeliness and personalization of intervention, and is applicable to fields such as medicine and education.

In a described embodiment a system for enhancing artificial intelligence language models is provided. The system includes a Neurotransmitter Simulation Module (NSM) configured to simulate dynamics of multiple neurotransmitters. The system further includes a State Interpreter configured to generate a multi-dimensional cognitive-emotional state vector based on analysing neurotransmitter levels and an Adaptive Parameter Adjustment Module (APAM) configured to adjust language model parameters based on the cognitive-emotional state vector. A language model is configured to generate natural language outputs using the adjusted parameters. A feedback loop mechanism is configured to evaluate quality of the natural language outputs and provide feedback signals to at least one of the NSM or the APAM.

This invention relates to the field of traditional Chinese medicine technology, and more particularly to a Jin medicine compound calming ointment that prolongs deep sleep and is non-addictive, as well as its preparation method. This invention is the first to use prolonging deep sleep duration as the core therapeutic target. The combined use of various herbs in this invention nourishes blood and calms the mind, nourishes yin and clears heat, and harmonizes the heart and kidneys, effectively treating insomnia caused by deficiency of heart and liver blood, disharmony between heart and kidneys, and yin deficiency with excessive fire. Furthermore, this invention, through the synergistic effect of multiple components, can effectively regulate the neurotransmitter GABA receptors, targeting and prolonging deep sleep, reducing the number of nighttime awakenings, fundamentally optimizing sleep structure, and also inhibiting excessive activation of the HPA axis, reducing abnormally elevated cortisol levels, thereby alleviating anxiety, breaking the vicious cycle of anxiety-insomnia, and effectively treating anxiety-related insomnia. Simultaneously, it has antioxidant effects, protects nerve cells, improves cerebral microcirculation, provides sufficient oxygen and nutrients to the brain, and creates a favorable physiological environment for the restoration of normal sleep rhythms.

The application discloses a neurotransmitter regulation interaction relationship model construction method and system, relates to the technical field of computational neuroscience, and comprises the following steps: constructing a neuron multimodal neurotransmitter co-release dynamics unit, defining small molecule neurotransmitter and neuropeptide respective vesicle pool state variables, and establishing a coupling release equation based on calcium dependence and regulatory protein selectivity, and outputting two types of neurotransmitter spatiotemporal release source terms; inputting the spatiotemporal release source terms into a three-dimensional brain space structure embedded with a receptor density map, solving a volume conduction equation, and generating a dynamic concentration field of a whole brain range of modulating neurotransmitters; according to a corresponding relationship between the dynamic concentration field and the local receptor density, calculating diffuse modulation input received by the neuron; based on the concentration of a specific modulating neurotransmitter in the dynamic concentration field, driving state evolution of an astrocyte cell unit, and outputting a concentration of a regulatory neurotransmitter released by the astrocyte cell; and integrating point-to-point synapse input, diffuse modulation input and the concentration of the regulatory neurotransmitter released by the astrocyte cell.

The application relates to an amino reactive matrix, a preparation method thereof and application thereof in mass spectrometry imaging, and belongs to the field of organic synthesis and spatial metabolomics research. The amino reactive matrix is applied to the field of spatial omics research of metabolic small molecules of biological tissue samples, and provides important technical support for realizing spatial distribution information of amino small molecules (such as neurotransmitters, amino acids and the like) in disease model tissue samples.

The application discloses a plant lactobacillus and application of the plant lactobacillus in a composition for preventing or treating a tic disorder, and belongs to the technical field of microorganisms. The technical problem to be solved is to provide a plant lactobacillus LP496 isolated from healthy breast milk, wherein the plant lactobacillus LP496 can significantly reduce a tic behavior, improve a stereotypic symptom, improve motor coordination and repair muscle strength damage, realize double neurotransmitter regulation by down-regulating dopamine and up-regulating serotonin, and has a significant protective effect on brain neuron damage. A technical solution point is that the plant lactobacillus LP496 has a preservation number of CGMCC No. 33499. The application further discloses a microbial agent containing the strain or a preparation of the strain, and application of the strain and the microbial agent in preparation of a composition for preventing or treating a tic disorder and related compositions, and provides a safe, effective and mild new microecological intervention scheme for the tic disorder.

Optical kit comprising two devices: a pair of daytime glasses to maximize exposure to the natural light spectrum (UV, visible, infrared) with visual correction, and a pair of nighttime glasses, with or without correction, that selectively block wavelengths of artificial light (blue, green, yellow, or orange) during the user's nocturnal waking hours between sunset and sunrise. The nighttime device uses dyes or multilayer filters to attenuate artificial wavelengths, thus protecting the user's circadian rhythm, hormones, neurotransmitters, proteins, and mitochondria, thereby increasing their well-being and cognitive or physical performance. (See abstract figure: Figure 1.)