1830 results about "Gut flora" patented technology

A systems biology approach is used to characterize and relate the intestinal (gut) microbiome of a host organism (e.g. a human) to physiological processes within the host. Information regarding the types and relative amounts of gut microflora is correlated with physiological processes indicative of e.g., a patient's risk of developing a disease or condition, likelihood of responding to a particular treatment, for adjusting treatment protocols, etc. The information is also used to identify novel suitable therapeutic targets and/or to develop and monitor the outcome of therapeutic treatments. An exemplary disease/condition is the development of hepatic encephalopathy (HE), particularly in patients with liver cirrhosis.

The invention relates to one or more systems and methods for creating a mixture of cultures used to replace intestinal flora. Specifically, the invention relates to methods and systems of treating diseases including Clostridium difficile and Crohn's disease by introducing a mixture of pure cultures of viable bacteria into the gastrointestinal tract.

The invention discloses compound functional sugar with a function of adjusting intestinal flora. The compound functional sugar contains functional oligosaccharide, L-arabinose, dietary fiber and probiotics and is characterized in that bifidobacterium, lactobacillus and other beneficial bacteria can be proliferated; meanwhile, the proliferation of escherichia coli, enterococcus and other harmful bacteria is restrained to adjust the intestinal flora; and the small intestine peristalsis can be promoted, the defecating time can be shortened, the defecation quantity can be increased to play a role in defaecation.

The present invention relates to microbial fodder additive, and a kind of microbial fodder additive comprising beneficial microbes and their metabolites and its preparation process and use. The microbial fodder additive is the mixture of fermented liquid or dry powder obtained with Bacillus subtilis, Bacillus cereus, lactobacillus and Saccharomyices cerevisiae and through high density deep layer liquid fermentation. It may be prepared into different specific liquid or powder preparations. The microbial fodder additive has high live bacillus content, long product preserving period and less foreign bacteria contamination, and has the functions of raise fodder utilization, promote animal's growth, increase animal product yield and quality, etc.

The invention provides an edible composition as well as a preparation method and application thereof. The edible composition comprises functional oligosaccharides and probiotics, wherein the functional oligosaccharides and the probiotics have synergistic effects and can conduce to obviously increasing the number of intestinal probiotics of animals and inhibiting increase of harmful bacteria and harmful substances, thus effectively regulating intestinal floras of animals and then enhancing the immunities based on the effects of the intestinal floras and preventing or treating the diseases, such as obesity, diabetes mellitus, hypertension, hyperlipidemia or tumors.

The invention discloses an infant milk power added with synbiotics, comprising the following components: fresh milk 40-68 gram; demineralized whey powder 15-34 gram; granulated sugar3-6 graml; vegetable oil 4-8 gram; compound prebiotics 0.4-20 gram; compound probiotic 1.0*10<5>-1.0*10<11> cfu. The inventive infant milk power can be ysed for building advantages of beneficial bacterium when a newborn infant starts colony valuation. Through adding probiotic, the number of probiotic is advanced to increase in a short time, through adding prebiotics having selectively increasing effect on probiotic, the added probiotic is performed with fast field setting, thereby maintaining advantages of probiotic in intestinal flora. The invention also markedly relieves diarrhoetic symptoms, and has definite treatment effect on diarrhea caused by rotavirus.

The present invention relates to the development of a targeted delivery system for the oral delivery of probiotics or therapeutic agent for various indications, including and not limited to active and prophylaxis treatment of Clostridium difficile infection, antibiotic associated diarrhea, irritable bowel syndrome, Crohn's disease, intestinal flora replacement, supplemental flora treatments for patients taking antibiotics, and for restoration of balance and signaling between the intestinal microbiome and the intestinal cells in patients under treatment of metabolic syndrome manifestations, specifically diabetes, insulin resistance, obesity, hyperlipidemia and hypertension.

The invention provides a lactobacillus helveticus microcapsule as well as the preparation and application thereof, pertaining to the embedding technology of lactobacillus helveticus and aiming at microencapsulating the lactobacillus helveticus so as to solve the problems of low embedding efficiency and embedding yield in single-layer or double-layer embedment. The technical proposal adopted by the invention is that isolated soy protein, microporous starch and sodium alginate are respectively taken as the first, the second and the third layers of wall materials for microencapsulation; the three-layer embedment is carried out to the lactobacillus helveticus for the first time, wherein, in the process of preparing bacterial suspension, an orthogonal optimization protective agent is adopted to improve the livability after freeze drying. The microcapsule of the invention has strong heat resistance and acid resistance, solves the inactivation problem caused by gastric acid, digestive enzyme and antibiotic, etc. to active bacillus, is capable of releasing when reaching large intestine, and balances intestinal flora. The reusability of fermented milk is good. The lactobacillus helveticus used by the invention enriches the variety of probiotic bacteria microcapsule and is a good dietary supplement.

The invention relates to the technical field of microorganism, and discloses a Lactobacillus reuteri and its application. The preservation number of the Lactobacillus reuteri CCFM8631 is CGMCC No.14394; the level of mice peripheral neurotransmitter 5-hydroxytryptamine can be significantlyimproved; the rise of the mice peripheral blood testonsterone level and the abundant abnormity of Blautia, Turicibacter, Oscillospira and Bifidobacterium in the intestinal flora by high glucose and high fatty diets are recovered; the tolerated simulative gastrointestinal fluid is rapidly planted in an intestinal tract, so as to significantly improve the pathological injury of metabolic syndrome mice liver and duodenum and rise of triglyceride and total cholesterol content in the serum by high glucose and high fatty diets are significantly improved; the Lactobacillus reuteri can be used for preventing, delaying or treating metabolic disorder such as metabolic syndrome, irritable bowel syndrome, and anxiety, depression and other metal diseases related to irritable bowel syndrome.

The invention discloses bifidobacterium longum and the application thereof and belongs to the technical field of biologics. The invention provides a bifidobacterium longum YS108R strain which has thecharacteristic of generating viscous exopolysaccharide, and has a remarkable improvement function on DSS (Dextran Sulfate Sodium) induced mouse colitis models. The strain has a relatively good capability of enduring simulated gastrointestinal fluids, is capable of remarkably reducing disease activity indexes of mice in the DSS induction period, and has an effective protection function on colon tissue. In addition, the bifidobacterium longum YS108R disclosed by the invention is separated from intestinal florae of healthy people, is free of toxic and/or side effects on human bodies, and has certain advantages when being compared with conventional medicine treatment. The strain can be used for preparing probiotic powder, fermented milk, and the like, and has wide market prospects.

The invention discloses a preparation method of a mushroom ferment beverage with effect of improving immunity, and belongs to the technical field of food beverages. According to the method disclosed by the invention, mushrooms and/or medicinal plants, fruit and ginseng are adopted as raw materials. The method comprises the following steps: slicing, chopping or crushing the raw materials; uniformly mixing the sliced, chopped or crushed raw materials so as to obtain a mixture; after adding sugar in the mixture, fermenting the mixture in ferment microorganisms; adding sugar when the sugar content is lowered; continuing fermentation so as to obtain the mushroom ferment beverage. According to the method disclosed by the invention, ferment bacteria can regulate intestinal flora and generate SOD (superoxide dismutase), so that the raw materials can be successfully fermented; the prepared ferment beverage contains protease, lipase, SOD, pectinase, lucid ganoderma, cauliflower fungus, pleurotus eryngii polysaccharide, rare ginsenoside, Rb2, C-K and the like. According to the method disclosed by the invention, the fermentation liquor and mycelium of the mushrooms can be directly used for fermentation; compared with sporophore, the raw materials are easier to obtain, and the method has the advantages of being short in fermentation cycle, easy in formula, simple in fermentation process, and the like.

The invention relates to a method for preparing a probiotic preparation for reducing blood lipid and adjusting intestinal flora, which comprises the following steps that: (1) Kefir-source lactobacillus plantarum MA2 is subjected to high-density culture to obtain a fermentation fluid, and the thallus density of the fermentation fluid is not less than 10cfu/mL; (2) the fermentation fluid is subjected to centrifugal collection to obtain thalli, and the thalli are added with a protective agent and are freeze-dried into bacterial powder; and (3) the freeze-dried bacterial powder is added with an oligosaccharide mixture, and a finished product of the probiotic preparation can be obtained after even mixing. The prepared probiotic preparation has a function of reducing the blood lipid, also has a physiological function of adjusting the intestinal flora at the same time, can treat and prevent high blood lipid symptoms, adjust the intestinal flora, is non-toxic and safe, has long retention period, and can be prepared into capsules, micro-capsules, granules, tablets and the like.

The invention discloses a composition and an application thereof in regulating intestinal flora of animals. The composition contains aloe, probiotics and prebiotics, wherein the mass ratio of the aloe to the probiotics to the prebiotics is (6 to 3 to 1)-(6 to 1 to 3). The inventor discovers that the composition disclosed by the invention can effectively promote the proliferation of useful bacteria such as bifidobacterium and lactobacilli in animal intestines, so as to effectively regulate the intestinal flora of animals; therefore, the composition can be used for preventing or treating diabetes on the basis of the effect of the intestinal flora.

The invention relates to an antibiotic-free piglet conservation material and a preparation method thereof. The conservation material comprises the following raw materials of puffed corn, wheat, a base material, efficient cream, soybean meal, fermentation soybean meal, whey powder, composite yeast, rice protein powder, stone powder, calcium hydrogen phosphate, lysine, methionine, threonine, choline chloride, liquid phytase, liquid xylanase, a acidifying agent, sodium butyrate and a premix compound. The antibiotic-free piglet conservation material can increase immunity of the piglet, prevents the piglet from generating drug resistance and appearing drug residue problems, maintains stability of intestinal flora, and improves digestion and absorption for forage of the piglet.

The invention discloses a nutritional health food with the function of improving gastrointestinal function and a preparation method thereof. The nutritional health food can be used for regulating the intestinal flora to improve the gastrointestinal function from the aspects of increasing the probiotics type and quantity, increasing the probiotics nutrient substance, inhibiting the growth of harmful bacteria and enhancing the immunity of human body. According to the preparation method, probiotics powder such as lactobacillus plantarum is used as the main raw material, and edible fungi extracts and modified dietary fibers are scientifically compounded; saussurea involucrata culture extracts which are capable of remarkably enhancing the immunity of human body, resisting inflammatory and easing pain, and have the functions of oxidation resistance, radiation resistance and fatigue resistance are used, so that while the intestinal probiotics flora types is increased, the fix planting capacity of the endogenous probiotics and exogenous probiotics in the intestinal tracts of human body is remarkably enhanced, and fix planting time of the endogenous probiotics and exogenous probiotics in the intestinal tracts of human body is prolonged remarkably, the growth and reproduction of the harmful bacteria, particularly the Gram negative bacteria, in the intestinal tracts are effectively inhibited, the forming of the probiotic floras in the intestinal tracts is fully regulated and the nutritional health food which is good in probiotic property, capable of remarkably enhancing the immunity of human body and has the effect of improving the gastrointestinal function is prepared.

The invention discloses a health food capable of improving intestinal floras and a preparation method of the health food. The intestinal floras are adjusted on a plurality of aspects of increasing the probiotics variety and quantity, adding probiotic nutrient substances, inhibiting the harmful bacterial growth and increasing the human immunity, so that the gastrointestinal functions are improved. With probiotic powder such as lactobacillus plantarum as a main raw material, an edible mushroom extract is scientifically compounded, and dietary fibers are modified, so that the human immunity can be significantly improved; a saussurea involucrate culture extract has the efficacies of resisting inflammation, relieving pain, and resisting oxidation, radiation and fatigue; the variety of the intestinal beneficial bacteria floras is increased; the field planting capacity of endogenous and exogenous probiotics in human intestinal tracts is significantly enhanced and the field planting time of endogenous and exogenous probiotics in human intestinal tracts is significantly prolonged; the growth and the reproduction of intestinal harmful bacteria, especially gram negative bacteria, are effectively inhibited; the components of the intestinal beneficial bacteria floras are fully adjusted; and the health food which is high in probiotic property, and is capable of significantly improving the human immunity and improving the intestinal floras is prepared.

The invention discloses a clostridium butyricum having a diarrhea treating effect. The strain is named as clostridium butyricum Cb-2 which is conserved in China Center for Type Culture Collection with the conservation number of CCTCC M2011384, in November 9th, 2011. A test proves that the clostridium butyricum disclosed by the invention has strong acid producing capability especially butyric acidproducing capability; and the clostridium butyricum has obvious effects on diseases, such as intestinal tract flora infection, acute and chronic diarrhea, irritable bowel syndrome and non-ulcer dyspepsia, caused by various reasons, and has no toxicity and harm. Thus, the clostridium butyricum or clostridium butyricum powder disclosed by the invention is used as a raw material for preparing a micro-ecological preparation and used for replacing sodium butyrate to be applied; and when a specific application is carried out, a clostridium butyricum preparation can be singly used as an active component to be prepared into the micro-ecological preparation together with corn starch, or, the clostridium butyricum preparation is mixed with at least one of other bacterial preparations and the corn starch to prepare a composite micro-ecological preparation.

The invention relates to anthony pig feed, which is prepared mainly by strictly controlling the quality of corns and adding a large amount of lactose, whey powder, fermented soybean meal, soya protein concentrate, plasma protein powder, fish meal, complex enzyme preparation, digestion acid, microbial agent and the like. The anthony pig feed obtained has a crude protein content of more than or equal to 18.6 percent, lysine content of more than or equal to 1.31 percent, digestible energy of more than or equal to 3,500Kcal/kg, an energy to protein ratio (Kcal/percent) of more than or equal to 188, a calcium content of more than or equal to 0.6 percent, a phosphorus content of more than or equal to 0.49 percent, a calcium to phosphorus ratio of more than or equal to 1.2:1 and a dietary electrolyte balance value (DEB) of more than or equal to 195 as well as high palatability, high digestibility and availability and low acid-binding capacity and can effectively regulate intestinal flora balance.

The present invention concerns a therapy aimed at language and/or social skills in infants through administration of components stimulating the development of a healthy intestinal flora.

The invention provides grain jelly. Grains(oat, purple rice, barley, red beans, seed of Job's tears, corns, millet and black rice), fruits(mulberry, cherry, yellow peaches, apricots, oranges and apples), edible gums(xanthan gum, carrageenin, agar and gelatin) serving as a solidifying gum, and flavoring additives(salt, granulated sugar, gourmet powder, essences and sodium citrate) are mixed in a ratio to obtain the jelly. The grain jelly is transparent, good in taste, soft and fresh, and rich in nutrients, belongs to the low-calorie and high-cellulose food, and is rich in vitamins B, other vitamins and mineral substances; and the grain jelly has the effects of adjusting intestinal flora, improving the intestinal wetness and strengthening a digestive function.

The present invention relates to nutritional food and drugs, particularly to a composition with characteristics of liver tonifying, kidney nourishing, intestine and stomach function conditioning, constipation improving, intestinal flora disorder improving, immunity regulation, calcium supplement, nutrient absorption promotion and no side effect. The composition comprises, by weight, 10-30 parts of cistanche deserticola or songaria cynomorium herb and 30-98 parts of one or a plurality of materials selected from probiotic bacteria, milk calcium, tartarian buckwheat and animal colostrum.

A composition containing bifidobacteria for adjusting intestinal flora and enhancing immunity is characterized by comprising, by weight, 0.01-10% of bifidobacteria, 10-50% of oligosaccharide, 0.01-10% of vitamin, and 0.01-10% of metals, with the balance being auxiliary materials. The composition containing bifidobacteria provided by the invention has functions of adjusting intestinal flora and enhancing immunity. The composition can be made into capsules, soluble granules, granules, tablets, etc., and applied in food, health product and pharmaceutical fields.

The invention discloses a probiotic-containing health food and a preparation method thereof, wherein intestinal florae are adjusted in many aspects of increasing the types and quantity of probiotics, increasing the nutrient substances of the probiotics, inhibiting the growth of harmful fungi, enhancing human immunity and the like, so as to improve gastrointestinal functions. Probiotic powders of lactobacillus plantarum and the like are taken as main raw materials, and edible fungi extract, modified dietary fibres, a saussurea involucrata culture extract capable of remarkably enhancing the human immunity, resisting inflammation and easing pain and having anti-oxidization, anti-radiation, anti-fatigue functions and the like are scientifically compounded, and then the planting capacity and the planting time of endogenous and exogenous probiotics in human intestinal tracts are remarkably improved and prolonged, the growth and reproduction of intestinal harmful fungi, especially, Gram-negative bacterium, are effectively inhibited, and the composition of intestinal probiotic florae is adequately regulated while the types of the intestinal probiotic florae are increased; therefore, a health food with high probiotic property, capable of remarkably enhancing human immunity and containing probiotics is prepared.

The invention discloses preparation and application of Clostridium butyricum and a live Clostridium butyricum preparation; Clostridium butyricum LXKJ-1 is collected in China Center for Type Culture Collection on 24 March, 2016 under CCTCC NO: M201613. A seed medium, fermentation medium formulation, culture conditions for Clostridium butyricum and a production of a preparation of live Clostridium butyricum are also disclosed. The Clostridium butyricum provided herein is tolerant to acids, bases and high temperature, is highly capable of producing butyric acid, can inhibit animal pathogens, such as Escherichia coli, Salmonella, Shigella, Staphylococcus aureus, Listeria monocytogenes, and Clostridium perfringens, and can prevent diarrhea in livestock and poultry due to Escherichia coli, Salmonella and Clostridium perfringens, improving intestinal flora balance, promoting the growth of livestock and poultry, relieving constipation in sows, improving egg weight for layers, improving eggshell quality for layers, and decreasing egg-feed ratio.