The invention discloses yellow serofluid bean curb dreg health-care rice wine and a preparation method thereof. The yellow serofluid bean curb dreg health-care rice wine is prepared from the following raw materials: by weight, 120-150 parts of yellow serofluid, 70-80 parts of glutinous rice, 30-40 parts of bean curb dreg, 2-3 parts of honeysuckle flower, 2-3 parts of balloonflower root, 1-2 parts of cistanche, 1-2 parts of eucommia, 1-2 parts of mulberry leaf, 2-3 parts of wolfberry leaf, 2-3 parts of hawthorne leaf, 1-2 parts of morinda officinalis, 1-2 parts of active dry yeast and 3-4 parts of red yeast rice. The beany flavor of the yellow serofluid is removed through fermentation treatment of the yellow serofluid, the bean curb dreg is fried to remove the beany flavor, the prepared yellow serofluid bean curb dreg health-care rice wine has a fine and smooth taste, a unique flavor, is rich in soybean dietary fiber, soybean whey protein, soybean oligosaccharides, soybean isoflavone and other nutrients, has heat clearing and detoxifying, phlegm eliminating and pus expelling, intestine moistening and bowel relaxing bowel relaxing, liver nourishing and kidney tonifying, wind expelling and dampness removing effects, and can prevent the occurrence of colorectal carcinoma, hypertension, hyperlipidemia, high cholesterol, diabetes and other diseases by long-term drinking.