17 results about "Serum cholesterol" patented technology

The present invention discloses an interfering RNA for inhibiting PCSK9 gene and use thereof. The interfering RNA comprises a nucleotide sequence set forth in any one or two or more of SEQ ID NOs: 1-40, 73-96. The interfering RNA of the present invention can better target and silence hepatic PCSK9 mRNA, reduce the protein level of PCSK9, enhance LDL-C metabolism, and reduce serum cholesterol, providing a solid technical foundation for the development of siRNA medicaments for the prevention, treatment, and symptom alleviation of PCSK9 gene-mediated diseases.

The invention discloses an interfering RNA (Ribonucleic Acid) for inhibiting a PCSK9 gene and application of the interfering RNA. The interfering RNA comprises any one or more than two nucleotide sequences as shown in SEQ ID NO: 1-40 and SEQ ID NO: 73-96. The interfering RNA can better target and silence mRNA of the liver PCSK9, reduce the protein level of the PCSK9, enhance LDL-C metabolism and reduce serum cholesterol, and a solid technical basis is provided for research and development of siRNA drugs for prevention and treatment of PCSK9 gene mediated diseases and symptom relief.

The invention discloses a pediococcus pentosaceus MDL511, which is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.35201, the preservation date is July 11, 2025, and the classification name of the strain is pediococcus pentosaceus. The pediococcus pentosaceus MDL511 has the advantages that the preservation number is CGMCC No.35201, the preservation number is CGMCC No.35201, the preservation date is July 11, 2025, and the classification name of the strain is pediococcus pentosaceus. The pediococcus pentosaceus MDL511 disclosed by the invention can be used for remarkably reducing weight gain and fat growth of mice caused by high fat diet, reducing serum cholesterol, LDL-C (Low Density Lipoprotein Cholesterol) and ALT (Atomic Lymphocyte Transferase) levels and remarkably improving hepatic lesions and fat accumulation caused by high fat diet, so that the MDL511 has a blood fat reducing effect, can be used for preparing blood fat reducing products and weight losing products and has a good development prospect.

Disclosed herein is a deuterated compound of Formulas (I) and (II) as an FTO inhibitor with improved pharmacokinetic properties with comparable selective FTO inhibition. Also disclosed herein is a pharmaceutical composition comprising the same, and a method of inhibiting weight gain, promoting weight loss, reducing serum LDL, cholesterol, LDL-c, or triglycerides, or treating obesity or an obesity-related disease (esp. obesity-related diabetes, hyperglycemia, diabetic nephropathy, hyperlipemia, coronary heart disease, atherosclerosis, hypertension, cardiovascular or cerebrovascular disease) or Alzheimer's disease by inhibiting FTO by using the compound disclosed herein.

The present invention provides a method for determining a mortality risk and / or probability of healthy lifespan of a cat; said method comprising determining the level of one or more biomarker(s) in one or more samples obtained from the cat, wherein the one or more biomarker(s) is selected from white blood cell count, haemoglobin, serum urea nitrogen, serum AST, serum chloride, serum total bilirubin, serum globulin, red blood cell count, serum sodium, serum cholesterol, serum potassium, serum alkaline phosphatase, and / or serum GGT.

This invention belongs to the field of traditional Chinese medicine technology. More specifically, it relates to the application of a processed product of Citrus reticulata peel or Citrus reticulata peel embryo (with bitterness removed) in the preparation of products for lowering lipids and preventing and treating hyperlipidemia. Compared with the original product, the processed product of Citrus reticulata peel or Citrus reticulata peel embryo provided by this invention significantly reduces bitterness while significantly enhancing its effects in lowering cholesterol and triglycerides and regulating blood lipids. This processed product helps maintain normal levels of serum cholesterol, triglycerides, and low-density lipoprotein, and can significantly improve liver damage caused by hyperlipidemia, thus having important application value in lowering lipids and protecting the liver.

The invention relates to a preparation method of alkaline health-preserving white spirit. The pH value of the alkaline health-preserving white spirit is close to that of human body fluid, so that the alkaline health-preserving white spirit can improve human body constitution, activate and regenerate cells and enhance immunity after being drunk for a long time, and is good in drinking taste and relatively light in liver and kidney burden after being drunk. Wherein the selected Chinese wolfberry fruits have the effects of promoting immunity, resisting aging, scavenging free radicals and resisting fatigue, and the Chinese dates can promote the generation of leukocytes, reduce serum cholesterol, improve serum albumin and protect the liver. Ganoderma lucidum is sweet and bitter in taste and slightly cold in nature and has the effects of clearing heat and moistening the lung. The herba artemisiae scopariae can promote liver cell membranes, prevent liver cell necrosis and promote liver cell regeneration and liver microcirculation, and the medicinal functions and taste of the baijiu are enriched in cooperation with various traditional Chinese medicinal materials and fruits. The preparation method is simple, ensures that the raw stock base liquor fully absorbs various nutritional ingredients, can shorten the production cycle, and is suitable for large-scale production.

The present invention discloses an anti - pyroptosis polypeptide and its application, relating to the technical field of biomedicine. The key points of its technical solution are: the anti - pyroptosis polypeptide is specifically used in the preparation of drugs for preventing and treating atherosclerosis. The amino acid sequence of the anti - pyroptosis polypeptide is shown as SEQ ID NO.1. The present invention firstly uses the anti - pyroptosis polypeptide to prepare drugs for treating and / or preventing atherosclerosis, and the effect of the anti - pyroptosis polypeptide in controlling atherosclerosis has been verified in cell models and animal models. In particular, the anti - pyroptosis polypeptide can enhance the viability of endothelial cells in the state of defective pyroptosis, significantly inhibit the expression of pyroptosis - related genes and proteins, and at the same time can reduce the levels of serum cholesterol and low - density lipoprotein in atherosclerotic mice, and reduce aortic lipid deposition and plaque formation. Moreover, when the anti - pyroptosis polypeptide of the present invention is used as a drug ingredient, it also has advantages such as low toxicity, small molecular weight, low immunogenicity and high druggability.

The invention provides curcumin composite nanoparticles capable of reducing serum cholesterol and a preparation method of the curcumin composite nanoparticles, and belongs to the technical field of nutritional active ingredient delivery systems. The curcumin-zein-chondroitin sulfate composite nanoparticles are prepared by mixing curcumin, zein and chondroitin sulfate stock solution in equal volume for reaction and then using an anti-solvent coprecipitation method. Compared with free curcumin, the curcumin-zein-chondroitin sulfate composite nanoparticles have better physical and chemical stability, biological activity and efficacy, and have a stronger blood fat reducing effect. According to the method provided by the invention, the physical and chemical stability and the efficacy performance of the curcumin are remarkably improved, and the curcumin has a good application prospect in the aspect of development of blood fat reducing functional products.

The invention relates to an improved wine brewing method, and aims to improve the quality and taste of wine. The quality and taste of the grape wine are closely related to microbial strains, and the grape wine which better retains the natural flavor of grapes and is more complex and elegant can be brewed by using specific microorganisms (red yeast compound yeast) and controlling and fermenting processes. The wine is bright in color and mellow in taste, contains higher alcohols, fatty acids, volatile acids, esters and the like of common wine, also contains natural monascus pigments, monacolin K and the like, has the health-care effects of reducing human serum cholesterol and the like, aims at public taste and is beneficial to body health.

This invention relates to compositions and methods relating a combination of naturally-occurring active ingredients, including active agents unrelated to statins, useful for the regulation total blood cholesterol. The inventive combination of active ingredients, including policosanol, mevinolic acid from dry yeast extract of red rice, dry extract of Lespedeza captitata, and dry grape seed extract, interrupts or inhibits the metabolic pathway leading to biosynthesis of cholesterol and cholesterol ester at multiple points and may also reduce high triglyceride levels. The present invention may be used to achieve normal blood serum LDL cholesterol concentrations and establish a healthy balance between LDL and HDL, all while significantly reducing the risk of statin-related side effects.

Provided are a compound of Formula (I) as an FTO inhibitor with improved and selective FTO inhibition, a pharmaceutical composition comprising the same, and a method of inhibiting weight gain, promoting weight loss, reducing serum LDL, cholesterol, LDL-c, or triglycerides, or treating obesity or an obesity-related disease (esp. obesity-related diabetes, hyperglycemia, diabetic nephropathy, hyperlipemia, coronary heart disease, atherosclerosis, hypertension, cardiovascular or cerebrovascular disease) or Alzheimer's disease by inhibiting FTO by using the compound disclosed herein.

The invention discloses application of lactobacillus rhamnosus cytoplasmic membrane vesicles in preparation of a medicine for treating non-alcoholic fatty liver, and relates to the technical field of microorganisms. The medicine is used for reducing the content of cholesterol, triglyceride, glutamic oxalacetic transaminase, high-density lipoprotein cholesterol and malondialdehyde in serum; the content of cholesterol and / or triglyceride in the liver tissue is reduced; at least one of reducing liver inflammatory response and / or reducing lipid deposition caused by a high fat diet; the non-alcoholic fatty liver disease is caused by high fat diet. The lactobacillus rhamnosus cytoplasmic membrane vesicles provided by the invention can effectively relieve metabolism and liver inflammation of organisms and delay the progress of fatty liver diseases caused by high fat diet.

The invention discloses a traditional Chinese medicine formula for dissolving artery plaque and a preparation method, and relates to the technical field of traditional Chinese medicine formulae, the traditional Chinese medicine formula comprises the following components by weight: 20-35 parts of Radix Astragali, 5-10 parts of safflower, 12-25 parts of Chinese angelica, 18-35 parts of ginseng, 6-18 parts of earthworm, and 25-40 parts of leech. According to the traditional Chinese medicine formula for dissolving the arterial plaque and the preparation method, the gingko can reduce serum cholesterol and reduce deposition of lipid on blood vessel walls, the hawthorn can regulate blood fat, reduce total cholesterol, triglyceride and the like and reduce material basis for formation of the arterial plaque, and the lotus leaf can reduce blood fat, contribute to reduction of lipid content in blood and cooperate with other medicines, so that the traditional Chinese medicine formula for dissolving the arterial plaque has a good effect on dissolving the arterial plaque. Plaque forming raw materials are reduced from the source, and the cyperus esculentus reduces lipid cores of artery plaques; safflower and peach kernel can improve blood circulation, reduce blood viscosity, inhibit platelet aggregation and prevent thrombosis.

The invention discloses a biomarker for liver cancer diagnosis and a prognosis method thereof, and relates to the field of medical biological detection, and the biomarker for liver cancer diagnosis comprises a TATA binding protein related factor 3 and a sterol regulatory element binding protein 2; the expression levels of the TATA binding protein related factor 3 and the sterol regulatory element binding protein 2 are subjected to immunohistochemical detection, and when the immunohistochemical score of the TATA binding protein related factor 3 is greater than or equal to 2 +, the TATA binding protein related factor 3 is highly expressed; when the immunohistochemical score of the sterol regulatory element binding protein 2 is greater than or equal to 2 +, the sterol regulatory element binding protein 2 is highly expressed; according to the biomarker for liver cancer diagnosis and the prognosis method of the biomarker, liver cancer patients with poor prognosis can be accurately screened out by detecting the expression level and serum cholesterol concentration of the TATA binding protein related factor 3 and the sterol regulating element binding protein 2, a basis is provided for personalized treatment, and the diagnosis accuracy is remarkably improved.

The invention discloses a preparation method of whole-grain instant porridge, belongs to the technical field of instant porridge, and aims to solve the problems that the instant porridge is glutinous in mouth feel, is not chewy, is poor in experience feeling, and does not have the functions of reducing serum cholesterol of a human body and regulating vegetative nerves of the human body. The composite chewy feed is prepared from the following components in percentage by weight: 30%-45% of rice, 25%-30% of wheat, 15%-20% of soybeans, 10%-14% of corn, 5%-10% of sweet potatoes, 6%-10% of an anti-caking agent, 15%-25% of amylase, 20%-25% of white granulated sugar, 17%-20% of grape seed oil, 30%-35% of a composite chewy additive solution, 45%-50% of sodium gluconate, 33%-40% of peptone and 23%-30% of an antioxidant. The PH is 5.5, the active environment of amylase can be adjusted, cooking juice can enter rice, wheat, soybeans, corn and sweet potatoes by adding peptone, the juice content of rice, wheat, soybeans, corn and sweet potatoes is further increased, serum cholesterol of a human body can be reduced by adding grape seed oil, and the nutritional value of the rice, wheat, soybeans, corn and sweet potatoes is increased. The vegetative nerve function of people is effectively regulated.

The invention particularly relates to an enzyme immobilized hollow multi-shell structure bionic artificial cell for accurately detecting cholesterol, which is characterized in that the artificial cell comprises a metal oxide / carbonate hollow multi-shell structure, an enzyme and an artificial cell membrane, the artificial cell membrane is uniformly distributed on the surface of the hollow multi-shell structure, and the enzyme is uniformly loaded in an internal cavity. The simple and safe preparation method of the artificial cell membrane can avoid toxicity and mechanical damage in a traditional coating method, and the layer-by-layer nested hollow multi-shell structure realizes structural simulation of cells and endows the cells with selective permeability and long-term stability of enzyme. The artificial cell has efficient mass transfer performance, accurate and rapid detection of cholesterol in a solution and serum is realized through enzymatic cascade catalytic reaction, the detection range is 50-300 [mu] M, and the lowest detection limit is as low as 4.9 [mu] M. The method can be applied to serum cholesterol detection, cholesterol detection is achieved through an artificial intelligence method based on an image recognition model, and the method is expected to be used for convenient detection of cholesterol.