49 results about "Symptom relief" patented technology

The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic / analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.

A two-stage medicine delivery system provides an initial dose of medicine and a second dose of medicine. The initial and second doses are capable of achieving a rapid pharmacological effect and a prolonged pharmacological effect, respectively. The two-stage medicine delivery system preferably delivers a craving reduction substance, in which case, the rapid and prolonged pharmacological effects include a rapid and prolonged craving reduction. Preferably, the delivery system is a nicotine delivery system which is provided in chewing gum form or lozenge form and which provides the nicotine in a transmucosally absorbable form. The two-stage medicine delivery system preferably releases a buffering agent which increases a pH level in a user's mouth to facilitate absorption of the medicine when the delivery system is placed in the user's mouth. A method of making the medicine delivery system also is provided. The system and apparatus can be adapted to reduce cravings for alcohol, food, drugs (e.g., cocaine, opiates and the like) and tobacco products, especially tobacco products containing nicotine.

The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic / analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.

The present invention relates to a disorder of the lower urinary tract, and in particular, reducing the symptoms (including treatment) of interstitial cystitis in vivo. In a preferred embodiment, the present invention relates to treatment formulations and methods for reducing interstitial cystitis in patients.

The present disclosure is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The disclosure also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic / analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.

The invention relates to specific chimeric antigen receptor T cells targeting CD19, and a preparation method and clinical application thereof. The present invention constructs a specific chimeric antigen receptor targeting CD19 and immune response cells modified by the chimeric antigen receptor based on a targeted human CD19 single-chain antibody sequence. The novel modified immune response cells can effectively target and attack a plurality of tumor cells, especially tumor cells with positive CD19 expressiion, and can be used to prepare a preparation for the treatment of tumors. The method for preparing the modified immune response cells targeting CD19 is simple, and the obtained modified immune response cells targeting CD19 have a high killing rate on tumor cells. Clinical verification shows that: after a million-grade low-dose back transfusion, patients with recurrent and refractory advanced CD19-positive lymphoma get a significant clinical symptom relief after two weeks of treatment, almost complete relief curative effect is obtained on the 77th day, and no fever caused by cytokine release syndrome and any neurotoxic side effect occur.

The present invention is directed to drug dosage forms that release an agent that raises the pH of a patient's gastrointestinal tract, followed by a non-steroidal anti-inflammatory drug. The dosage form is designed so that the NSAID is not released until the intragastric pH has been raised to a safe level. The invention also encompasses methods of treating patients by administering this coordinated release, gastroprotective, antiarthritic / analgesic combination unit dosage form to achieve pain and symptom relief with a reduced risk of developing gastrointestinal damage such as ulcers, erosions and hemorrhages.

The invention discloses a feedback type nerve electric stimulation system with an in vitro sleep detection device. The feedback type nerve electric stimulation system comprises a pulse generator, an electrode and the in vitro sleep detection device, wherein the electrode is connected with the pulse generator, the in vitro sleep detection device is used for judging whether patients are in the deep sleeping state or not, when the in vitro sleep detection device judges that the patients are in the deep sleeping state, and control signals are sent to the pulse generator by the in vitro sleep detection device or through a patient controller so that the pulse generator automatically weakens or stops the pulse signal output, so the feedback type automatic regulation of the output pulse signals of the pulse generator is realized, the power consumption wasted because the stimulation can be completely stopped through the symptom relief or elimination at night in the heavy sleep state of the patients with movement disorders, parkinsonism and the like, the service life of the nerve electric stimulation system is greatly prolonged, and the economic load born by the patients is reduced.

The invention relates to a spleen-warming and stomach-benefiting food therapy traditional Chinese medicine composition, spleen-warming and stomach-benefiting food therapy grilled chicken or food therapy meat and a manufacture method thereof. The composition comprises the following weight composition that: relative to per 10kg of hen, 10g of lotus leaf, 15g of semen raphani, 6g of clove, 6g of fennel, 30g of north hawthorn, 5g of nutmeg, 5g of cinnamon, 6g of pepper, 10g of medlar, 5g of fructus amomi, 10g of elsholtzia, 9g of agastache rugosus, 15g of purple perilla, 30g of stir-fried coix seed, 15g of fermented soybean, 10g of peach kernel, 10g of almond, 10g of semen pruni, 10g of fructus cannabis, 20g of rhizoma polygonati and 15g of poria cocos are adopted. The spleen-warming and stomach-benefiting food therapy grilled chicken or the food therapy meat is the food therapy grilled chicken or the food therapy meat obtained through being boiled by brine manufactured by the spleen-warming and stomach-benefiting food therapy traditional Chinese medicine composition. The internal-organ-nourishing medicated food and medicated chicken or the food therapy meat has the effects of warmingthe spleen and benefiting the stomach in clinics. For patients with the deficiency-cold spleen and stomach, after the medicated food treatment, the total efficiency of the medicated food group on thechronic constipation symptom relief is superior to that of a control group.

The invention belongs to the field of traditional Chinese medicines and in particular discloses an externally used traditional Chinese medicine for treating thrush. The traditional Chinese medicine consists of the following raw materials in part by weight: amur corktree bark, lalang grass rhizome, reed rhizome, figwort root, rose, mint, golden thread, medicinal evodia fruit, watermelon peel, white hyacinth bean, ginger, persist calyx of garden eggplant, powder on the surface of dried persimmons and mulberry bud. The traditional Chinese medicine is easy to prepare, has good absorption effect, obvious curative effect, no side effect and high safety and contributes to symptom relief of patients in time.

The invention discloses a Camellia nitidissima / fructus cannabis health-preserving tea which is prepared from Camellia nitidissima, fructus cannabis, radix polygonati officinalis, kudzu root, hawthorn and fructus momordicae. The Camellia nitidissima has the effects of resisting bacteria, diminish inflammation, clearing away heat and toxic material and inducing diuresis to reduce edema; the fructus cannabis has the effects of moistening dryness, smoothing the intestines, promoting urination, treating stranguria, promoting blood circulation and dispersing pathogenic wind; the radix polygonati officinalis has the effects of nourishing yin to moisten dryness, clearing away liver-fire to treat eye disease; the hawthorn has the effects of stimulating circulation to end stasis, and activating blood circulation to dissipate stasis; the kudzu root has the effects of relieving exterior syndrome, relieving heat, promoting salivation and quenching thirst; the fructus momordicae has the effects of benefiting the skin, beautifying the face, reducing the blood fat and blood sugar and enhancing the taste; and thus, the prepared product is a favorable sweet tea beverage which has the effects of removing heat from the liver, improving eyesight, clearing away the lungheat and moisturizing dryness, nourishing the stomach, promoting salivation, clearing away heat and toxic material, lowering the blood fat and blood sugar, beautifying the face, strengthening the body and prolonging life. The formula of the Camellia nitidissima / fructus cannabis health-preserving tea is summarized through long-term practice of people. All the raw materials are familiar flowers, herbs and fruits of native plants, and thus, have sufficient and guaranteed sources. The tea has the characteristic of pure and sweet mouthfeel, can perform the functions of symptom relief and health care, and has the effects of health care and health preservation when being drunk for a long time.

The present invention provides a method and devices for the treatment of hemorrhoids. The method involves the combined delivery of cryotherapy and medication therapy. The devices described provide cryotherapy for immediate relief of pain, itching, reduction of swelling, reduction of existing bleeding, shrinkage of hemorrhoidal tissue, and promotes healing of affective tissues. Subsequent medication release from these devices provides sustained healing and protracted relief of symptoms. The devices may be disposable and may be used externally or internally, and may include an invasive or non-invasive applicator.

The invention relates to the technical field of traditional Chinese medicines and particularly discloses traditional Chinese medicine ointment for treating clavus. The traditional Chinese medicine ointment for treating clavus is prepared by mixing raw materials, namely rohdea japonica, nodular branch of pine, castor bean, brucea fruit, balsamine, gall nuts, black plum, centipede, plum borneol, pinellia tuber, peach kernels, fructus persicae immaturus, selfheal spike, ginkgo leaves and seed of Chinese sumac, according to a certain weight ratio. The traditional Chinese medicine ointment for treating clavus is simple in preparation, long in drug effect duration, free from side effects, high in safety and low in production cost, has a good absorption effect and a remarkable treatment effect, and is beneficial to the timely symptom relief for patients.

To provide a spraying device and a spraying method for moisture mist that supply at least a micro liquid to the eye, and can be used for dry eye symptom relief, drug delivery, allergy prevention, relaxation, and the like. The above-described problem is solved by a spraying device (1, 31) that supplies at least a micro liquid, and includes a spraying element (16) that sprays a mist-like substance containing the micro liquid onto a local region (50). The raw material is a liquid raw material or a solid raw material that may include a medicinal additive. The medicinal additive is preferably selected from among menthol, analgesics, antibiotics, antiallergic agents, steroids, intraocular pressure-lowering agents, and the like. The spraying device (1, 31) may be an eyeglasses-type spraying device (1) in which the local region (50) is configured by a rim (3) and a temple (6) of eyeglasses, or a cup-type spraying device (31) in which the local region (50) includes an opening (32).

The invention discloses a walnut / red date buccal tablet, belonging to the field of green health food. The walnut / red date buccal tablet is prepared from walnut kernel, red date and honey.By using the walnut kernel, the walnut / red date buccal tablet can reduce the absorption of cholesterol by the intestinal tract, obviously lowers the contents of total cholesterol and harmful cholesterol, and has the preventive effect on hypertension, arteriosclerosis and cardiovascular diseases; and the red date can enhance the myodynamia, eliminate fatigue and expand blood vessels, and has favorable actions on preventing and treating cardiovascular diseases. The honey has the effects of moistening dryness, eliminating toxin, whitening and beautifying the face, loosening the bowel to relieve constipation and prolonging life, and the product has the effects of nourishing the blood, benefiting the intelligence and strengthening the brain. The walnut / red date buccal tablet is a green health food capable of beautifying the face, strengthening the body and prolonging life, and tastes sweet. The walnut / red date buccal tablet is summarized through long-term practice of people. All the raw materials are familiar nutritious edible materials, so the product has the advantages of reasonable formula and favorable mouthfeel, and is convenient to eat and suitable for both young and old people. The walnut / red date buccal tablet can perform the functions of symptom relief and health care when being eaten for a long time.

A multi-modal absorption, medicine-delivery lozenge is provided. The lozenge includes a lozenge base for oral administration into a user's mouth, a medicinal active ingredient including an antihistamine convertible between ionized and non-ionized states, and a buffer present in an effective amount for establishing a pH in the individual's mouth which is characterized by a simultaneous presence of a first pharmacologically effective dose of the non-ionized form of the medicinal active ingredient for transmucosal absorption, and a second pharmacologically effective dose of the ionized form of the medicinal active ingredient for gastro-intestinal absorption.

The invention relates to a medicine carrying punctual plug, which comprises a cylindrical main body extending along a center shaft, wherein the main body is formed by biodegradable polymer materials; medicine grooves are formed in the surface of the main body; and antibiotic medicine and biodegradable polymers are mixed and are contained in the medicine carrying grooves. The medicine carrying punctual plug has the advantages that the release of the antibiotic medicine is controlled through the biodegradable polymers; and the medicine can be released in a long treatment period such as half a month or one month according to a certain release curve such as uniform release, or release in a release speed regulating mode according to the disease condition of xerophthalmia or the release in a mode that that the release speed is high when the medicine carrying punctual plug is implanted into the lacrimal duct for a short time, and then the release speed is decelerated along with the disease symptom relief in future. After the xerophthalmia is relieved, the medicine carrying punctual plug starts to gradually degrade; and finally, carbon dioxide and water are generated and are discharged out from the nasolacrimal canal, so that the inflammation can be effectively relieved.

The invention relates to a preparation method and purification method of recombinant humanized urate oxidase, a nucleic acid sequence encoding recombinant humanized urate oxidase protein, a plasmid vector expressing the recombinant urate oxidase protein and engineering bacteria. According to the invention, a human uricase pseudogene sequence is used as a template to carry out mutation on the sitethereof, so that the recombinant humanized urate oxidase with activity and higher homology (92.6%) than the human pseudogene sequence is obtained. Meanwhile, a purification process is improved, and the activity loss of uricase in the purification process is reduced to the maximum extent. The high-dose humanized urate oxidase prepared by the method shows obvious effect of relieving pain caused by sodium urinate crystallization after two days of dosing, and has the same symptom relief degree as a sham operation group after 4 days of dosing, which indicates that the symptom is completely relievedand obvious progress is realized.

The invention relates to the field of traditional Chinese medicine application and particularly relates to a traditional Chinese medicine for treating damp-heat diarrhea. The traditional Chinese medicine for treating damp-heat diarrhea is prepared through mixing raw materials, namely cucumber leaf, plantain, artemisia annua, tangerine peel, hyacinth-bean flower, ageratum, rhubarb root, talcum, licorice root, costus root, Chinese mosla herb, atractylodes rhizome and honeysuckle flower, according to a certain weight ratio. The traditional Chinese medicine is simple in preparation, good in absorption effect, long in drug effect duration, remarkable in treatment effect, free from side effects, high in safety and low in production cost and is beneficial to the prompt symptom relief for patients.

The invention relates to the field of biotechnology, in particular to a method for establishing an HT-29 cell inflammatory model and application. The invention comprises two steps: cell treatment andresult detection. The cell processing step comprises the following steps: adding HT-29 cells are seeded on 24-well plates and cultured overnight, after the cells adhere to the wall, the culture mediumis changed, the human source TNF-alpha is added, the final concentration is 20mg / ml, after 12 hours of co-culture, LPS is added into the culture medium, the final concentration is 1 [mu]g / ml, and theculture time is 15 hours. The result detection includes expressing detection of protein and mRNA of TLR4, NF-kB, TNF-alpha and IL-1beta in treated HT-29 cells.. The invention establishes HT-29 cell inflammatory model, which provides a screening method at that drug cell level for the treatment or symptom relief of ulcerative colitis, and provides a method step for the treatment mechanism researchof the drug with therapeutic effect on the animal ulcerative colitis model.

The present invention provides a method for preventing / slowing aging and / or reducing menopause symptoms in humans by orally administering an effective amount of germination-activated Ganoderma lucidum spores (GLSs) to humans. The treatment for menopause is especially effective in male patients. GLSs are effective as an antioxidant to reduce free radical damage, particularly by increasing the amount of the reduced form glutathione (GSH) and the superoxide dismutase (SOD) activity. GLSs can also increase testosterone level in blood and improve depression, particularly geriatric depression, in elderly male patients.

The invention relates to a traditional Chinese medicine for treating nephritis, which is made from the Chinese medicinal herbs such as Chinese ephedra, gypsum, forsythia, alisma rhizome, adsuki bean and couchgrass root. The traditional Chinese medicine for treating nephritis has reasonable formula, and is characterized by quick action, short treatment course and high curative rate for symptoms such as hematuria, proteinuria, dropsical limbs and the like, caused by acute and chronic nephritis, no side effect, and both symptom relief and permanent cure.

The present invention relates to a composition for treating osteoarthritis and a method for preparing the same, and more specifically, relates to a composition comprising hydrophilized sulfasalazine as an active ingredient and hyaluronic acid so as to enable effective treatment of osteoarthritis such as degenerative osteoarthritis by preventing joint wear in addition to symptom relief through intraarticular or local administration, and a method for preparing the same. When such a composition for osteoarthritis treatment is prepared by the preparation method according to the present invention, the dissolved state is maintained beyond a neutralization step after dissolution, preventing precipitation of sulfalazine by salting out occurring after neutralization, and thus a composition comprising high concentration of sulfasalazine can be prepared, and the composition prepared accordingly is highly effective in treating osteoarthritis, particularly degenerative osteoarthritis, through the intraarticular or local administration, since it comprises high concentration of sulfasalazine which had to be formulated at low concentration by conventional method due to poor solubility.

The invention relates to the field of application of traditional Chinese medicines and particularly discloses a traditional Chinese medicine composition for treating dyspepsia of children. The traditional Chinese medicine composition is prepared by mixing the following raw materials according to a certain weight ratio: tetrapanax papyriferus, cluster mallow fruits, ginger peel, phaseolus calcaratus, Chinese waxgourd peel, coix seeds, rhizoma dioscoreae septemlobae, dianthus superbus, polygonum cuspidatum, rhizoma curcumae longae, selaginella tamariscina, flos albiziae, hawthorn fruits, radix gentianae, Chinese yam, radix glycyrrhizae and Chinese dates. The traditional Chinese medicine composition is simple in preparation, good in absorbing effect, and long-lasting in efficacy, has a remarkable curative effect and no side effects, is high in safety and low in production cost and facilitates symptom relief of patients in real time.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating acute pharyngitis. The traditional Chinese medicine for treating the acute pharyngitis is obtained by using folium isatidis, burdock, radix sophorae tonkinensis, Chinese barberry roots, dayflowers, herba houttuyniae, dandelion, lampwick grass carbon, honeysuckle, chrysanthemum indicum, radix glycyrrhizae, plum blossom borneol, blackberry lilies, achyranthes aspera, lalang grass rhizome, ophiopogon roots and moutan bark as raw materials, and mixing the raw materials according to a certain weight ratio. The traditional Chinese medicine is simple in preparation, good in absorbing effect, long in medicine effect duration effect, significant in effect, free of side effects, high in safety and low in production cost, and facilitates timely symptom relief of a patient.

The invention belongs to the field of traditional Chinese medicine application and particularly discloses traditional Chinese medicine ointment for treating rosacea. The traditional Chinese medicine ointment for treating rosacea is prepared through mixing raw materials, namely nidus vespae, loquat leaf, radix trichosanthis, gardenia, angelica root, plantain root, Kalimeris indica, almond, litharge, rhubarb root, white gourd seed, castor bean, clove, cayratia japonica and semen pharbitidis, according to a certain weight ratio. The traditional Chinese medicine ointment is simple in preparation, good in absorption effect, long in drug effect duration, remarkable in treatment effect, free from side effects, high in safety and low in production cost and is beneficial to the prompt symptom relief for patients.

The present disclosure relates to an acupoint stimulation device and an acupoint stimulation method using the same. The acupoint stimulation device includes: a power supply unit configured to supply power; a controller configured to generate an electrical stimulus signal applied to a skin of the subject; and an electrical stimulation unit including two or more electrodes configured to receive power from the power supply unit and to supply the stimulus signal to the acupoint area, wherein the electrodes are arranged in a state of being electrically insulated from each other and are in electrical contact with the skin of the subject. Thereby, it is possible to provide an appropriate amount of stimulation required for treatment and symptom relief by providing stimulation to an accurate acupoint position.