202 results about "Ocular surface" patented technology

The invention discloses a tear total IGE detection method and system based on multi-modal data fusion. The method comprises the following steps: acquiring ocular surface images, physiological parameters and environmental allergen data, and acquiring historical medical data from a hospital information system; preprocessing and feature extraction are performed, patient symptom description is analyzed in combination with a natural language processing technology, and related image block features are recognized; adjusting a space-time attention weight based on frequency domain analysis and transfer learning, inputting a lightweight Transform model, and predicting a tear total IgE concentration and an allergy risk score; whether a trace tear sampling program is started or not is judged, and the actually measured concentration of total tear IgE is detected through a disposable micro-fluidic chip; and integrating all information by using a Bayesian adaptive filtering algorithm to determine the total tear IgE level. By implementing the method provided by the invention, the sampling amount is extremely small, the detection time is short, the environmental interference can be dynamically corrected, and the absolute concentration value is output, so that the dual requirements of clinical precise diagnosis and treatment and home monitoring are met.

The invention relates to an intelligent eyelid fixing and tear flow guide composite device, which belongs to the technical field of medical instruments and comprises an arc-shaped main body frame, a multi-section pressure sensing fixing wing, a miniature liquid guide groove, a humidity compensation module and a central control unit. The multi-section pressure sensing fixed wing can be dynamically attached to the shape of an eyelid and is matched with the flexible contact layer to achieve biomechanical self-adaptive adjustment, and contact pressure is evenly dispersed. The miniature liquid guide groove serves as an efficient tear drainage path, and tears are rapidly discharged in combination with negative pressure suction. The humidity compensation module accurately covers the cornea surface through an annular atomization nozzle, and the ocular surface is kept moist. And the central control unit is used for monitoring in real time and adjusting fixed pressure, atomization intensity and negative pressure parameters in a linkage manner to form an intelligent feedback closed loop. The device solves the problems that a traditional rigid eye speculum is uneven in pressure distribution, low in tear management efficiency, poor in dissection adaptability and the like, the steady state maintaining effect of the ocular surface microenvironment in an ophthalmologic operation can be improved, and tissue damage and operation interruption are reduced.

The invention relates to the field of biological medicine, in particular to a carrier-free nanoparticle which is formed by self-assembly of cyclosporine A and costunolide through intermolecular weak interaction. The invention also provides a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of medicines for treating xerophthalmia. The carrier-free nano eye drops based on the synergistic effect of Chinese and western medicines are used for anti-inflammatory treatment of the xerophthalmia, a new strategy is provided for precise diagnosis and treatment of the xerophthalmia, the problems of single target spot, limited curative effect and the like in traditional treatment are solved, and more efficient inflammation control is expected to be achieved. While the curative effect is improved, the tolerance risk caused by long-term use is reduced, double optimization of the curative effect and safety is realized, and the limitation of traditional single drug treatment is broken through. By adopting the carrier-free nano preparation, the delivery efficiency of the medicine on the ocular surface is effectively improved, the bioavailability is enhanced, powerful support is provided for improving the curative effect of the medicine, and the carrier limitation bottleneck is broken through.

The invention relates to the technical field of pharmaceutical preparations, and provides double-shell JAK inhibitor nanoparticles, a preparation method thereof and targeted delivery eye drops. The double-shell JAK inhibitor nanoparticle provided by the invention comprises a core, an inner shell and an outer shell, wherein the core comprises a nanostructure lipid carrier and a JAK inhibitor; the inner shell layer is a cationic polymer, and the outer shell layer is hyaluronic acid. Through the design of the positive charge inner shell layer and the negative charge outer shell layer, the dual functions of mucosa adhesion and active targeting are achieved, the surface of the nanoparticle is electronegative finally, cytotoxicity possibly caused by direct exposure of a cationic polymer is reduced, non-specific aggregation of the cationic polymer and electronegative protein in tears is avoided, and the stability of tears is improved. And the stability of the preparation is improved. The eye drops provided by the invention can obviously prolong the residence time of the JAK inhibitor on the ocular surface, enhance the cornea permeability, can actively target to ocular inflammatory cells, and have a wide application prospect.

The invention relates to the technical field of biological medicines and ophthalmic medicines, in particular to a herbal exosome composition for eye care and treatment and a preparation method thereof. The composition comprises a synergistic combination of herbal exosomes and mesenchymal stem cell exosomes, and further comprises a nano slow-release carrier system. Wherein the herbal exosome is extracted from a traditional herbal plant liquorice by combining gradient centrifugation with a molecular exclusion chromatography method, and herbal active ingredients, namely astragaloside and quercetin, are loaded in the exosome by adopting an electroporation method, so that the pharmacological activity of the exosome is enhanced. The nano slow-release carrier system is of a two-phase slow-release structure; an inner phase is a phospholipid complex loaded with herbal exosomes and mesenchymal stem cell exosomes, and an outer phase is temperature-sensitive hydrogel; the compound is in a liquid state at room temperature, and is rapidly converted into a gel state after being dropped into the ocular surface, so that the retention time of the medicine on the ocular surface is remarkably prolonged, the bioavailability is improved, and the targeting slow release capability aiming at ocular surface tissues is endowed to the compound.

The invention relates to a comprehensive manipulator for ocular surface surgery, which belongs to the technical field of medical instruments and comprises a universal host, a disposable manipulator and a replaceable disposable functional head, and the universal host integrates an intelligent control module, a precise fluid driving component and a safe closed-loop system and has the functions of automatic recognition and surgery mode presetting. Accurate parameter regulation and control and operation safety protection can be realized; the disposable operation hand tool adopts a sterile design and an ergonomic structure, is provided with a quick butt joint mechanism and a magnetic attraction connecting part, and is adaptive to different functional heads; the replaceable disposable functional head has various special types and can replace traditional cotton swabs to achieve operations such as flushing, suction and precise dosing. According to the platform, cross contamination can be eradicated, ocular surface injury is reduced, the operation standardization level and operation efficiency are improved, dependence on doctor experience is reduced, and the clinical requirements for accuracy and safety of ocular surface operation are met.

The invention relates to the technical field of medical medicines, and discloses a composition for relieving eye strong light burn and a preparation method thereof. The composition is prepared from the following components in percentage by weight: 0.5 to 3 percent of sodium aliphatate, 30 to 50 percent of corn starch, 25 to 45 percent of talcum powder, 1 to 4 percent of cresol, 5 to 15 percent of flos chrysanthemi indici, 0.05 to 0.5 percent of radix scutellariae, 0.01 to 0.1 percent of flos carthami, 0.1 to 1 percent of aqueous solvent and the balance of water. The preparation method comprises the following steps: crushing medicinal materials; preparing a water-phase matrix containing a water-based solvent and sodium aliphatate; performing dry mixing on corn starch, talcum powder and the medicinal material fine powder; and mixing the water phase and the solid phase, adding cresol, homogenizing, adjusting the pH value, and sterilizing to obtain a paste or pasty composition. The composition can effectively relieve ocular surface pain, lacrimation and foreign body sensation caused by strong light burn through cooperation of multiple ways of physical protection, anti-inflammatory repair and oxidation resistance.

This invention belongs to the field of contact lens technology, specifically providing a method for designing scleral lenses based on ocular surface and scleral topography. Based on the topography of the anterior surface of the patient's cornea and sclera, the method divides the anterior surface of the cornea and sclera into meridians at equal angles, and designs the surface profile curves of the anterior and posterior surfaces of the scleral lens according to the morphology of the patient's cornea and sclera. Finally, 3D reconstruction is used to obtain the 3D surface profile data of the scleral lens. The optical zone of the scleral lens can be designed in various ways depending on the different shapes of the patient's eyeball; the transition zone can be designed in diverse ways to ensure the thickness of the intraocular fluid at certain locations based on the ocular surface morphology; and the landing zone smoothly conforms to the anterior surface of the sclera. This invention maximizes conformity to the patient's ocular surface morphology, ensures the uniformity of the intraocular fluid, and maintains a high degree of matching with the ocular surface, thereby achieving trial-free scleral lens fitting, improving clinical accuracy and efficiency, and enhancing patient safety and satisfaction.

The invention provides a nanoparticle penetrating cornea as well as a preparation method and application thereof. The nanoparticle comprises a cationic liposome G2-C14, an inner core formed by aliphatic polyester and an amphiphilic polymer, and a shell modified by polysaccharide, the hydrophobic drug and the siRNA are loaded in the inner core. According to the nano-particles provided by the invention, through polysaccharide surface modification, ocular surface adhesion and trans-epithelium transport capability are enhanced, multi-barrier penetration of the eye is realized, the nano-particles are effectively delivered to a focus area of posterior segment of the eye, the delivered siRNA targets to silence the expression of age-related macular degeneration pathogenic genes, and the hydrophobic drug removes active oxygen and inhibits release of inflammatory factors, so that the anti-aging effect of the nano-particles is improved. The focus thickness is synergistically reduced.

The present invention provides formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I) and methods for treating ocular surface pain by administering such formulations. The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4 H-quinazolin-3-yl)-benzonitrile.

An amniotic membrane insert configured for self-retaining, sutureless, clear-cornea application to an ocular surface. The insert has an outer edge and an inner edge inside the outer edge. The inner edge defines an opening sized to extend around a circumference of a cornea. The outer edge of the insert has a shape that is non-circular in which a height of the insert is greater than a width of the insert. Related devices, systems, and methods are provided.

The utility model relates to the technical field of medical instruments, and provides an eyeball surface flushing unit and a flusher, the flushing unit comprises a needle seat and a hollow needle tube, the needle tube comprises a flushing end and a connecting end, the connecting end is connected with the needle seat, the cross section of the needle tube is oval or kidney-round, the long axis of the cross section is 1.4-3mm, and the short axis of the cross section is 1.0-2mm. And the end part of the flushing end of the needle tube is blunt and flat. A trumpet-shaped flushing part is arranged at the flushing end of the needle tube, and a flushing opening of the flushing part is oval or kidney-shaped. And the length of the needle tube is 3-5cm. The needle tube has the advantages that the size of the hole of the needle tube is larger than that of a traditional needle tube, water flow is thicker, compared with traditional thin water flow, the impact force of the water flow is smaller, the situation that the water flow is splashed to pollute the full retinoscope and form water drops due to too large impact force of the water flow is avoided, the view of an operator cannot be affected, and smooth operation is guaranteed. In addition, the oval section is combined, water flow is flattened, and the flushing effect is better compared with a circular design.

The application relates to the technical field of ophthalmic material preparation, and particularly discloses a kind of biopolymer membranes, a preparation method thereof and application in ophthalmic surgery.The biopolymer membrane comprises the following raw material components by weight: polyvinyl alcohol 5-10 parts;gelatin 3-6 parts;sodium lignosulfonate 10-20 parts;carboxymethyl cellulose 3-6 parts;natural extract 1-3 parts;water 200-300 parts.Studies have shown that the biopolymer membrane can promote the proliferation of human corneal epithelial cells;therefore, it has important application value when used in ophthalmic surgery for the treatment of ocular surface damage.

The application provides an eye Tibetan medicine composition, a preparation and a preparation method and application thereof, and relates to the technical field of dry eye. The eye Tibetan medicine composition contains 80-120 parts by weight of berberis bark extract and 80-120 parts by weight of Qinghai dracocephalum extract. The eye preparation is prepared by mixing the eye Tibetan medicine composition and a solvent. The eye preparation can repair ocular surface tissue damage caused by dry eye and restore the normal secretion function of lacrimal glands.

The present disclosure provides compositions comprising at least one compound of Formula (I), suitable for application to the ocular surface. The present disclosure also provides methods of making compositions comprising at least one compound of Formula (I). The present disclosure further provides methods of using compositions comprising at least one compound of Formula (I) to reduce intraocular pressure, provide neuroprotection, and / or treat ocular conditions such as glaucoma.

The invention relates to the technical field of medical preparations, in particular to moisturizing and repairing type artificial tear as well as a preparation method and application thereof. Comprising the following steps: preparing effective components including high-molecular-weight polydeoxyribonucleotide and hyaluronic acid or a salt thereof into a homogeneous-phase stable composite solution, sterilizing, filtering, and aseptically packaging, the artificial tear formed by selecting high-molecular-weight polydeoxyribonucleotide and high-molecular-weight sodium hyaluronate as effective components has a relatively good repairing effect on tissues, can form long-term moisturizing and lubrication on ocular surfaces, is suitable for treating xerophthalmia, repairing cornea, relieving inflammatory response and the like, and has a good application prospect. Important market values and clinical application prospects are realized.

In certain embodiments, an ophthalmic system for assessing a tear film of an eye comprises measuring devices and a computer. The measuring devices detect light reflected from the eye, where an ocular surface of the eye comprises the tear film, and generate data from the reflected light that describes the eye. The computer aligns the data corresponding to the same location for a plurality of locations, assesses the data at the locations to detect one or more abnormalities of the tear film, and determines a tear film description from the assessment of the data at the locations.

This invention involves co-transfecting cells with an AAV vector plasmid carrying the target gene, a packaging plasmid providing Rep / Cap proteins, and a helper plasmid providing adenovirus assistance. The transfected cells are cultured under suitable conditions to produce viral particles containing recombinant AAV. Cells and culture supernatant are collected, cells are lysed to release the virus, and the viral particles are purified by centrifugation. A membrane-penetrating peptides or their derivatives are then modified onto the AAV capsid protein. Results show that the gene editing system combined with membrane-penetrating peptides or their derivatives enhances editing efficiency, effectively penetrates ocular surface tissues, and inhibits ocular neovascularization.

The present invention relates to a protein tyrosine kinase inhibitor and an ophthalmic preparation thereof. The protein tyrosine kinase inhibitor not only effectively antagonizes the activity of a VEGFR receptor tyrosine kinase, but also improves the pharmacokinetic properties thereof, while exhibiting high selectivity in inhibiting the activity of an "off-target" EGFR tyrosine kinase, thereby reducing or avoiding side effects, particularly those affecting the eyes. The preparation can greatly improve the solubility of the protein tyrosine kinase inhibitor compound, prolong the residence time of the compound on the ocular surface, increase exposure in fundus tissue, and improve the bioavailability.

Disclosed are methods, systems, media, apparatus, devices, and other implementations, including a method that includes determining blood flow characteristics at an ocular surface of an eye of a patient, determining characteristics of blood vessels at the ocular surface of the eye based on the determined blood flow characteristics, and deriving one or more ocular redness grading scales indicative of inflammation levels of the eye of the patient based on the determined characteristics of the blood vessels at the ocular surface of the eye.

The invention discloses hydrogel loaded with repair-promoting and antioxidant peptides as well as a preparation method and application of the hydrogel, and belongs to the technical field of preparation of medical materials. According to the preparation method, firstly, polypeptide with the amino acid sequence of CEYWVKWCGEKGPAGERG is synthesized, and the polypeptide has antioxidant activity and cell proliferation promoting activity and has good structural stability and enzymatic degradation resistance; and loading the polypeptide into the hyaluronic acid hydrogel to obtain the hyaluronic acid hydrogel. The prepared hydrogel loaded with the repair-promoting and antioxidant peptide has excellent injectable performance and cornea spreadability, can enhance the retention of the polypeptide on the ocular surface, effectively solves the technical problem of high administration frequency of the existing preparation, has good cell and tissue compatibility, and has no adverse reaction in vivo.

The present invention provides an amniotic membrane-loaded contact lens, its preparation method, and its application. This invention innovates the bonding method between amniotic membrane and contact lens, replacing the previous method of simply bonding the amniotic membrane and contact lens with medical biological glue. This simplifies the bonding process between amniotic membrane and contact lens, making it suitable for industrial application. It also addresses the issues of traditional sutured amniotic membranes, which suffer from decreased mechanical support, rupture, and uneven coverage over time as they cover the ocular surface. The optimization and selection of materials not only meet the basic requirements of a non-toxic and harmless adhesive, but also take into account biocompatibility and the cornea's requirements for contact lens oxygen permeability. The use of amniotic membranes is more comfortable, eliminating the need for complex surgical procedures and the irritation associated with sutures. The design of using a contact lens as an amniotic membrane support allows amniotic lenses to provide superior support and protection for the covered ocular surface.

A method for continual monitoring of a tear film integrity of a user's eye. Method includes determining a blink pattern of user's eye, using a means for detecting blinks of user's eye; measuring a temperature of an ocular surface of user's eye, at a set of at least two time instants within an inter-blink time interval of user's eye, using at least one temperature sensor; determining a rate of change in measured temperature for set of at least two time instants, based on a time interval between set of at least two time instants; comparing rate of change in measured temperature with a first threshold value; and when rate of change in measured temperature is greater than first threshold value: deeming tear film integrity of user's eye as broken.

This invention discloses a blueberry anthocyanin nutritional solid composition for relieving eye discomfort. The composition comprises blueberry anthocyanin solid powder, algal oil powder, zinc gluconate, and selenium-enriched yeast, and may optionally contain lipid nutrients containing gamma-linolenic acid, as well as food additives and excipients. Oral administration of this composition provides the body with various nutritional supports related to ocular surface function and ocular moisture, helping to maintain tear secretion levels, improve tear film stability, and support the normal physiological state of the corneal epithelium, thereby relieving eye dryness and discomfort caused by environmental stimuli or increased eye strain. Animal experiments showed that after 14 days of continuous administration of the composition, experimental mice exhibited a significantly increased tear secretion volume compared to the control group without the composition, with an increase of approximately 165%. Corneal fluorescein staining scores were also significantly reduced, indicating improved ocular surface condition and significantly enhanced eye comfort.

The invention discloses a jerusalem artichoke composition for relieving asthenopia and application thereof. Comprising 40-60 parts of jerusalem artichoke leaf and jerusalem artichoke peel mixed extract and 10-15 parts of inulin. The jerusalem artichoke leaf and jerusalem artichoke peel mixed extract is obtained by extracting functional components through enzymolysis, microwave and other processes. The invention further provides a product for relieving asthenopia. The product comprises 40-60 parts of jerusalem artichoke leaf and jerusalem artichoke peel mixed extract, 10-15 parts of inulin, 0.5-1 part of angelica sinensis powder, 0.2-0.6 part of safflower powder, 6-10 parts of Borojo powder and 6-10 parts of green plum powder. The jerusalem artichoke leaves and the jerusalem artichoke barks are used as raw materials and are combined with the inulin to be used as the composition for relieving asthenopia, and the composition is safe, free of toxic and side effects and capable of effectively maintaining the moist ocular surface, adjusting the contraction and relaxation capacity of ciliary muscles and adjusting intestinal flora; the asthenopia problems such as dry eyes, photophobia and aching pain can be effectively relieved.

Disclosed herein are methods for treating an ocular surface disorder by administering a therapeutically effective amount of at least one lysophosphatidic acid receptor (LPAR) modulator to a subject.

The invention relates to the technical field of medical instruments, in particular to a frameless amniotic membrane mirror device, a manufacturing method and a using method, and the frameless amniotic membrane mirror device comprises an amniotic membrane tissue layer and a biocompatible thin film layer formed by spraying a mixed solution of polymethyl acrylate and polyvinyl alcohol; the overall diameter of the device is 14 mm, the rise of the device is 6.2 + / -0.1 mm, and the device can be directly implanted into the ocular surface to cover the cornea without a frame support. The manufacturing method comprises the steps of amniotic membrane treatment, model eye forming, mixed solution preparation, membrane spraying and forming, trimming and sterilization. The application method relates to implantation after surface anesthesia, fitting observation and subsequent taking-out. Through the frameless conformal fitting design, the problems that an existing framed amniotic membrane mirror is displaced and cannot be worn by a patient with strong foreign body sensation and shallow conjunctival sac are solved, and meanwhile secondary trauma of a suture operation is avoided. And the residual film after the amniotic membrane is dissolved can continuously provide protection, and the amniotic membrane has the advantages of good fitness, high patient comfort, simplicity and convenience in operation and good safety.

The utility model relates to the field of medical instruments, and discloses an auxiliary wearing device for a corneal bandage mirror, which comprises a mirror bracket, the mirror bracket comprises two mirror frames, each mirror frame is fixedly connected with a mirror leg, and a through space is arranged in each mirror frame; the number of the separating mechanisms is four, each glasses frame is connected with two separating mechanisms, the two separating mechanisms on the same glasses frame are used for separating the upper eyelids from the lower eyelids and opening the eyelids, and each separating mechanism comprises a rotating arm rotationally installed on the corresponding glasses frame and a patch rotationally installed on the rotating arm and used for being attached to the eyelids; the manual mechanism is manually operated and is used for applying a rotating acting force to the rotating arm; the distribution direction of the two glasses frames is the X direction, the wearing direction of the glasses frame is the Y direction, the distribution direction of the two groups of separating mechanisms on the same glasses frame is the Z direction, and the X direction, the Y direction and the Z direction are perpendicular to each other, so that hands are prevented from being in direct contact with eyelids, the occurrence probability of ocular surface inflammation is reduced, and the glasses are safer and more sanitary.

Disclosed herein are cold slurry formulations, devices, and methods for reducing symptoms of ocular surface discomfort. Cold slurry formulations containing ice, a freezing temperature reducing agent, and optionally a lipid are disclosed. Disclosed are devices and methods for protecting a target ocular surface from contact with a cold slurry formulation for maintaining the target ocular surface at a temperature desired to alleviate symptoms of ocular surface discomfort. A stand-alone device configured to receive a cold slurry formulation for maintaining a target ocular surface at a temperature desired to alleviate symptoms of ocular surface discomfort is disclosed. Devices and methods for protecting the cornea and / or eyelids of a subject from frozen cold plasma formulations applied or injected directly or indirectly to the target ocular surface are disclosed. A kit containing a plurality of syringes for applying multiple doses of cold slurry to a target ocular surface is disclosed.

This invention proposes a flexible air-blowing device for measuring intraocular pressure (IOP), comprising an ocular surface IOP measurement optical system and a pulsed airflow jet system. The light emitted from the fixation lamp of the ocular surface IOP measurement optical system passes sequentially through a fixation beam splitter and a first semi-transparent mirror before reaching the ocular surface. The imaging light from the ocular surface passes sequentially through a first semi-transparent mirror, a second semi-transparent mirror, and an ocular surface imaging lens group before reaching an ocular surface imaging CCD. The pulsed airflow jet system is positioned along the optical path from the first semi-transparent mirror to the ocular surface and includes a rigid metal gas storage chamber. Inside the rigid metal gas storage chamber is a flexible pressure-stabilizing gas chamber. The inlet of the flexible pressure-stabilizing gas chamber is connected to a constant pressure replenishment valve, and the outlet is connected to a rigid jet nozzle. The rigid jet nozzle extends out of the rigid metal gas storage chamber and is aligned with the ocular surface, with its axis coaxial with the optical path from the first semi-transparent mirror to the ocular surface. This invention optimizes the output characteristics of the pulsed airflow, comprehensively improving the accuracy and stability of IOP measurement.