332 results about "Ocular surface" patented technology

This invention relates to a pair of intelligent, multimodal smart eyeglasses designed for adaptive vision, biometric ocular monitoring, and predictive emergency response. The system integrates multilayer lenses filled with electrochromic gel and surrounded by elastic structures to enable dynamic focal length modulation in response to user visual behavior. An array of sensors—including visible light, ultraviolet, micro-cameras, infrared emitters, gyroscopes, and ultrasonic transceivers—collects multispectral data to evaluate environmental and physiological parameters. Real-time data processing is performed by an embedded quantum microcontroller, which manages light transmittance, detects eye fatigue, maps ocular surfaces, and identifies hemodynamic abnormalities such as fainting, seizure, or ocular stroke. Advanced imaging techniques, such as ultrasonic ptychography and wave diffraction analysis, enable non-invasive 3D mapping of ocular layers and internal eye motion. The system also supports wireless communication with external platforms including smartphones, vehicles, and brain-machine interfaces, enabling proactive safety interventions. These features work in tandem to support early diagnosis of critical conditions, protect vision, and personalize user experiences through machine learning and adaptive feedback mechanisms.

Disclosed herein are methods for treating or preventing ophthalmic and dermatologic conditions in a patient, including ocular surface conditions such as blepharitis. The methods can include topically administering directly to an ocular surface of one or more eyes of a patient in need of treatment thereof an effective amount of an isoxazoline parasiticide, formamidine parasiticide, or other active ingredient, formulated into an ophthalmic composition, the ophthalmic composition further comprising a pharmaceutically acceptable vehicle. Compositions are also disclosed.

The invention relates to the technical field of biological medicine, in particular to eye drops containing recombinant protein as well as a preparation method and application of the eye drops. Comprising the following components: 0.01%-1% of recombinant human TFF3 protein, 0.1%-1% of an osmotic pressure regulator, 0.08%-2% of a pH regulator, 0.05%-0.15% of a thickening agent, 0.01%-0.1% of a surfactant, 0.01%-0.1% of a protective agent and the balance of water for injection, the traditional Chinese medicine composition can be used for treating the xerophthalmia, can promote wound healing and cell migration, has the effects of inhibiting inflammation and cell apoptosis, and can act on a plurality of target spots at the same time, so that the tear film stability is improved, ocular surface inflammation is inhibited, the vicious circle of the xerophthalmia is broken, and the xerophthalmia is treated more comprehensively and effectively; the problems that in the prior art, xerophthalmia medicine targets are single, and xerophthalmia cannot be comprehensively and effectively treated are solved.

The invention discloses a tear total IGE detection method and system based on multi-modal data fusion. The method comprises the following steps: acquiring ocular surface images, physiological parameters and environmental allergen data, and acquiring historical medical data from a hospital information system; preprocessing and feature extraction are performed, patient symptom description is analyzed in combination with a natural language processing technology, and related image block features are recognized; adjusting a space-time attention weight based on frequency domain analysis and transfer learning, inputting a lightweight Transform model, and predicting a tear total IgE concentration and an allergy risk score; whether a trace tear sampling program is started or not is judged, and the actually measured concentration of total tear IgE is detected through a disposable micro-fluidic chip; and integrating all information by using a Bayesian adaptive filtering algorithm to determine the total tear IgE level. By implementing the method provided by the invention, the sampling amount is extremely small, the detection time is short, the environmental interference can be dynamically corrected, and the absolute concentration value is output, so that the dual requirements of clinical precise diagnosis and treatment and home monitoring are met.

The invention provides a laser confocal ocular surface image stitching method based on deep learning. Efficient and accurate image stitching is realized through unsupervised learning. Firstly, an ocular surface image is preprocessed, and a data set is constructed; then, a multi-scale feature pyramid is constructed by using a convolutional neural network, image features are automatically extracted and pre-aligned, and image alignment is optimized through global motion aggregation and local motion correction technologies. Thirdly, constructing a content fusion generative adversarial network which comprises a generator and a discriminator to smooth the fused image and generate a spliced image conforming to human eye perception; a staged training strategy is adopted, image alignment is optimized firstly, and then image smooth fusion is achieved. And finally, automatically finishing image alignment and fusion by using the trained network to obtain a seamless large-view confocal ocular surface image. According to the method, the splicing precision and robustness are improved, the method is suitable for image splicing in different environments, and the splicing success probability is remarkably improved.

The invention relates to an intelligent eyelid fixing and tear flow guide composite device, which belongs to the technical field of medical instruments and comprises an arc-shaped main body frame, a multi-section pressure sensing fixing wing, a miniature liquid guide groove, a humidity compensation module and a central control unit. The multi-section pressure sensing fixed wing can be dynamically attached to the shape of an eyelid and is matched with the flexible contact layer to achieve biomechanical self-adaptive adjustment, and contact pressure is evenly dispersed. The miniature liquid guide groove serves as an efficient tear drainage path, and tears are rapidly discharged in combination with negative pressure suction. The humidity compensation module accurately covers the cornea surface through an annular atomization nozzle, and the ocular surface is kept moist. And the central control unit is used for monitoring in real time and adjusting fixed pressure, atomization intensity and negative pressure parameters in a linkage manner to form an intelligent feedback closed loop. The device solves the problems that a traditional rigid eye speculum is uneven in pressure distribution, low in tear management efficiency, poor in dissection adaptability and the like, the steady state maintaining effect of the ocular surface microenvironment in an ophthalmologic operation can be improved, and tissue damage and operation interruption are reduced.

Disclosed herein are compositions which can be used in methods for treating or preventing ophthalmic and dermatologic conditions in a human subject, including ocular surface conditions such as blepharitis or rosacea. The compositions can be topically administered directly to an eye, eyelid, or eyelashes of the patient for targeted local activity.

The invention relates to the field of biological medicine, in particular to a carrier-free nanoparticle which is formed by self-assembly of cyclosporine A and costunolide through intermolecular weak interaction. The invention also provides a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of medicines for treating xerophthalmia. The carrier-free nano eye drops based on the synergistic effect of Chinese and western medicines are used for anti-inflammatory treatment of the xerophthalmia, a new strategy is provided for precise diagnosis and treatment of the xerophthalmia, the problems of single target spot, limited curative effect and the like in traditional treatment are solved, and more efficient inflammation control is expected to be achieved. While the curative effect is improved, the tolerance risk caused by long-term use is reduced, double optimization of the curative effect and safety is realized, and the limitation of traditional single drug treatment is broken through. By adopting the carrier-free nano preparation, the delivery efficiency of the medicine on the ocular surface is effectively improved, the bioavailability is enhanced, powerful support is provided for improving the curative effect of the medicine, and the carrier limitation bottleneck is broken through.

The invention discloses a dry eye disease course supervision and prediction method and system based on AI image recognition, and relates to the technical field of medical image processing, and the method comprises the steps: obtaining blink behavior video data, meibomian gland infrared imaging data and time sequence ocular surface microvessel image data; analyzing the blink behavior video data, and extracting blink feature data; performing image processing on the infrared imaging data of the meibomian glands, and extracting feature data of the meibomian glands; carrying out binarization and thinning processing on the sequential ocular surface microvascular image data, and extracting blood vessel feature data; standardizing the blood vessel feature data, and fusing to generate a comprehensive feature vector; inputting the comprehensive feature vector into a classification model, and judging a dry eye disease course stage; executing trend analysis based on historical data of the comprehensive feature vector, and generating prediction data and intervention suggestion data; the method has the beneficial effects that through multi-modal image data fusion analysis, accurate monitoring and prediction of the xerophthalmia course are realized, and a scientific basis is provided for clinical intervention.

The present invention provides formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I) and methods for treating ocular surface pain by administering such formulations. The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.

The invention relates to the technical field of pharmaceutical preparations, and provides double-shell JAK inhibitor nanoparticles, a preparation method thereof and targeted delivery eye drops. The double-shell JAK inhibitor nanoparticle provided by the invention comprises a core, an inner shell and an outer shell, wherein the core comprises a nanostructure lipid carrier and a JAK inhibitor; the inner shell layer is a cationic polymer, and the outer shell layer is hyaluronic acid. Through the design of the positive charge inner shell layer and the negative charge outer shell layer, the dual functions of mucosa adhesion and active targeting are achieved, the surface of the nanoparticle is electronegative finally, cytotoxicity possibly caused by direct exposure of a cationic polymer is reduced, non-specific aggregation of the cationic polymer and electronegative protein in tears is avoided, and the stability of tears is improved. And the stability of the preparation is improved. The eye drops provided by the invention can obviously prolong the residence time of the JAK inhibitor on the ocular surface, enhance the cornea permeability, can actively target to ocular inflammatory cells, and have a wide application prospect.

The invention belongs to the technical field of biomedical materials, and relates to a high-adhesion Janus artificial cornea as well as a preparation method and application thereof. The invention provides an artificial cornea, which is characterized in that a coating containing epsilon-PLL and 4-arm-PEG-NHS is distributed on a collagen skeleton EB-Col, and the functional group ratio of-NHS to-NH2 in the coating is 1: (0.6-1.4), and the molar ratio is 1: (0.6-1.4). The invention also relates to a corresponding high-adhesion Janus artificial cornea, and a preparation method and application thereof. The artificial cornea has instant and stable adhesion capability, gives consideration to optical transparency and mechanical and adhesion properties, can well adapt to the shape of a wound, is convenient to use, high in practical operability and mild in reaction, and is particularly suitable for being applied to cornea repair materials in the ophthalmology department, and the strong wet tissue adhesion property of the artificial cornea can adapt to a dynamic ocular surface moist environment.

The invention relates to the technical field of biological medicines and ophthalmic medicines, in particular to a herbal exosome composition for eye care and treatment and a preparation method thereof. The composition comprises a synergistic combination of herbal exosomes and mesenchymal stem cell exosomes, and further comprises a nano slow-release carrier system. Wherein the herbal exosome is extracted from a traditional herbal plant liquorice by combining gradient centrifugation with a molecular exclusion chromatography method, and herbal active ingredients, namely astragaloside and quercetin, are loaded in the exosome by adopting an electroporation method, so that the pharmacological activity of the exosome is enhanced. The nano slow-release carrier system is of a two-phase slow-release structure; an inner phase is a phospholipid complex loaded with herbal exosomes and mesenchymal stem cell exosomes, and an outer phase is temperature-sensitive hydrogel; the compound is in a liquid state at room temperature, and is rapidly converted into a gel state after being dropped into the ocular surface, so that the retention time of the medicine on the ocular surface is remarkably prolonged, the bioavailability is improved, and the targeting slow release capability aiming at ocular surface tissues is endowed to the compound.

The present invention discloses a fully wireless ocular surface pressure monitoring system based on a multi-frequency phase-shift decoupling self-calibration algorithm, relating to the technical field of intelligent ophthalmic detection. The system comprises a wearable three-layer contact lens, wherein the outer layer is embedded with a capacitive eyelid pressure sensor and a first spiral coil, and the inner layer is embedded with a piezoresistive intraocular pressure sensor and a second spiral coil, which are respectively tuned to different center frequencies to modulate pressure changes into radio frequency signals. Externally powered receiving glasses or eye masks comprise a multi-frequency transmitting coil, a rectifier circuit and a receiving coil, which supply energy to the sensing structure in the contact lens and sense and obtain a composite signal formed by spatial superposition, which is transmitted to a processing circuit and then sent to a mobile computing terminal. The terminal performs multi-frequency decoupling, sparse matrix separation and temporal self-calibration processing to generate calibration curves of eyelid pressure and intraocular pressure, thereby realizing real-time perception of dual parameters in the eyes-closed state. The system has the advantages of compact structure, high signal separation accuracy and high degree of wirelessness.

The present application describes the synthesis, formulation and uses of systems comprising conjugates or materials prepared therefrom, capable of retaining systems on the ocular surface.

The present invention relates to a method for inducing the differentiation of corneal epithelial cells from pluripotent stem cells. More specifically, the present invention relates to a method for autonomously differentiating pluripotent stem cells, such as human iPS cells, into ectodermal cell lineage in a serum-free medium without using feeder cells and inducing the differentiation of the resultant ocular surface ectodermal lineage cells into corneal epithelial cells.

Described herein are methods of treating a disease, disorder or a condition associated with dry eye caused by a multifactorial disease of ocular surface, comprising administering to a subject in need thereof a pharmaceutical composition comprising a therapeutically effective amount of a modified FGF-1 polypeptide.

The invention discloses an eyelid morphological parameter measurement method based on a reconstruction-segmentation network of a conjoined architecture, and relates to the field of image processing, and the method comprises the steps: obtaining an ocular surface image, and respectively constructing an ocular surface image classification data set and an ocular surface image segmentation data set; constructing a reconstruction-segmentation network of a conjoined architecture based on dynamic parameter convolution; the reconstruction-segmentation network comprises a reconstruction task part and a segmentation task part; training the reconstruction task part by using the ocular surface image classification data set; embedding the trained encoder of the reconstruction task part into the segmentation task part as a dynamic convolution module, and training a reconstruction-segmentation network by using the ocular surface image segmentation data set to obtain a trained reconstruction-segmentation network; and inputting a to-be-detected ocular surface image into the trained reconstruction-segmentation network, segmenting a cornea region and a palpebral fissure region, and measuring the morphological parameters of the eyelid by using a measurement module. According to the invention, the accuracy of image segmentation and eyelid morphological parameter detection is improved.

Methods of treating anterior or vitreous chamber ocular diseases by administering ophthalmic pharmaceutical compositions of roflumilast topically to the ocular surface of the eye of a patient. The methods involving topical administration of ophthalmic pharmaceutical compositions of roflumilast to the ocular surface of a patient three or four times a day at more frequent and higher concentration, which can provide significant therapeutic activity to the anterior and vitreous chamber compartments of the eye using dosing regimens involving higher concentrations and less frequent administration than other treatment regimens.

The utility model relates to a red light irradiation device for myopia physiotherapy. The red light irradiation device comprises a red light irradiation assembly used for conducting red light irradiation on fundus so as to conduct myopia physiotherapy; the positioning assembly is used for collecting an ocular surface image and determining positioning information based on the ocular surface image; the moving assembly comprises at least one moving platform, the moving platform moves in the moving direction corresponding to the moving platform, and the moving assembly is operated to move the red light irradiation assembly in the at least one moving direction based on the positioning information so that the red light irradiation assembly can conduct red light irradiation on the fundus. According to the scheme of the utility model, by adding the positioning assembly in the red light irradiation device for myopia physiotherapy, the red light irradiation light source can be automatically aligned with the ocular surface (such as pupils and irises), so that the utilization rate of fundus red light irradiation is effectively improved, and the myopia physiotherapy effect is remarkably improved.

The invention relates to a comprehensive manipulator for ocular surface surgery, which belongs to the technical field of medical instruments and comprises a universal host, a disposable manipulator and a replaceable disposable functional head, and the universal host integrates an intelligent control module, a precise fluid driving component and a safe closed-loop system and has the functions of automatic recognition and surgery mode presetting. Accurate parameter regulation and control and operation safety protection can be realized; the disposable operation hand tool adopts a sterile design and an ergonomic structure, is provided with a quick butt joint mechanism and a magnetic attraction connecting part, and is adaptive to different functional heads; the replaceable disposable functional head has various special types and can replace traditional cotton swabs to achieve operations such as flushing, suction and precise dosing. According to the platform, cross contamination can be eradicated, ocular surface injury is reduced, the operation standardization level and operation efficiency are improved, dependence on doctor experience is reduced, and the clinical requirements for accuracy and safety of ocular surface operation are met.

The utility model discloses a cotton ruler for positioning and measuring a mucous membrane surface. The cotton ruler comprises a cotton ruler head part and a cotton ruler holding part which are fixedly connected, the cotton ruler head part is of a cone structure with a cross section which is gradually increased from the head end to the bottom, the cotton ruler head part is made of memory foam, the bottom surface of the cotton ruler head part is polygonal or fan-shaped, the polygonal or fan-shaped bottom surface at least comprises a V-shaped measuring edge, and the measuring edge is provided with a V-shaped measuring surface. The conical surface of the cotton ruler head is provided with linear scales used for marking the length along the two sides of the V-shaped measuring side respectively. The cotton ruler is a ruler used for tissue measurement on fragile surfaces such as mucosa, when the cotton ruler is applied to measurement of fragile tissue of eyes, the cotton ruler has safety and comfort in use of the ocular surface, has the functions of positioning, pressing and tissue isolation and protection, and can adapt to and meet the measurement requirements in the ophthalmic examination and treatment process.

The invention discloses a preparation method of a pegylation acoustic catalysis effect black phosphorus loaded biological enzyme nano particle, which is a novel nano composite material based on material chemistry and pharmaceutical chemistry, and bacterial keratitis is treated by using the unique acoustic catalysis property of the nano particle. Nanoparticle synthesis mainly comprises the following steps: 1) pretreatment of commercial black phosphorus; (2) uploading biological enzyme iron-curcumin to black phosphorus in situ; and (3) synthesizing hyaluronic acid coupled phospholipid polyethylene glycol (DSPE-coated PEG2000-HA) and modifying the biological enzyme black phosphorus nanoparticles. The finally obtained nano composite material has good biocompatibility, ocular surface adhesion, biological enzyme activity and acoustic catalytic treatment effect on bacterial biofilm infection of eyes.

In certain embodiments, an ophthalmic system for assessing a tear film of an eye comprises measuring devices and a computer. The measuring devices detect light reflected from the eye, where an ocular surface of the eye comprises the tear film, and generate data from the reflected light that describes the eye. The computer aligns the data corresponding to the same location for a plurality of locations, assesses the data at the locations to detect one or more abnormalities of the tear film, and determines a tear film description from the assessment of the data at the locations.

The invention relates to the technical field of medical medicines, and discloses a composition for relieving eye strong light burn and a preparation method thereof. The composition is prepared from the following components in percentage by weight: 0.5 to 3 percent of sodium aliphatate, 30 to 50 percent of corn starch, 25 to 45 percent of talcum powder, 1 to 4 percent of cresol, 5 to 15 percent of flos chrysanthemi indici, 0.05 to 0.5 percent of radix scutellariae, 0.01 to 0.1 percent of flos carthami, 0.1 to 1 percent of aqueous solvent and the balance of water. The preparation method comprises the following steps: crushing medicinal materials; preparing a water-phase matrix containing a water-based solvent and sodium aliphatate; performing dry mixing on corn starch, talcum powder and the medicinal material fine powder; and mixing the water phase and the solid phase, adding cresol, homogenizing, adjusting the pH value, and sterilizing to obtain a paste or pasty composition. The composition can effectively relieve ocular surface pain, lacrimation and foreign body sensation caused by strong light burn through cooperation of multiple ways of physical protection, anti-inflammatory repair and oxidation resistance.

This invention belongs to the field of contact lens technology, specifically providing a method for designing scleral lenses based on ocular surface and scleral topography. Based on the topography of the anterior surface of the patient's cornea and sclera, the method divides the anterior surface of the cornea and sclera into meridians at equal angles, and designs the surface profile curves of the anterior and posterior surfaces of the scleral lens according to the morphology of the patient's cornea and sclera. Finally, 3D reconstruction is used to obtain the 3D surface profile data of the scleral lens. The optical zone of the scleral lens can be designed in various ways depending on the different shapes of the patient's eyeball; the transition zone can be designed in diverse ways to ensure the thickness of the intraocular fluid at certain locations based on the ocular surface morphology; and the landing zone smoothly conforms to the anterior surface of the sclera. This invention maximizes conformity to the patient's ocular surface morphology, ensures the uniformity of the intraocular fluid, and maintains a high degree of matching with the ocular surface, thereby achieving trial-free scleral lens fitting, improving clinical accuracy and efficiency, and enhancing patient safety and satisfaction.

The invention provides a nanoparticle penetrating cornea as well as a preparation method and application thereof. The nanoparticle comprises a cationic liposome G2-C14, an inner core formed by aliphatic polyester and an amphiphilic polymer, and a shell modified by polysaccharide, the hydrophobic drug and the siRNA are loaded in the inner core. According to the nano-particles provided by the invention, through polysaccharide surface modification, ocular surface adhesion and trans-epithelium transport capability are enhanced, multi-barrier penetration of the eye is realized, the nano-particles are effectively delivered to a focus area of posterior segment of the eye, the delivered siRNA targets to silence the expression of age-related macular degeneration pathogenic genes, and the hydrophobic drug removes active oxygen and inhibits release of inflammatory factors, so that the anti-aging effect of the nano-particles is improved. The focus thickness is synergistically reduced.

The present invention provides formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I) and methods for treating ocular surface pain by administering such formulations. The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4 H-quinazolin-3-yl)-benzonitrile.

An amniotic membrane insert configured for self-retaining, sutureless, clear-cornea application to an ocular surface. The insert has an outer edge and an inner edge inside the outer edge. The inner edge defines an opening sized to extend around a circumference of a cornea. The outer edge of the insert has a shape that is non-circular in which a height of the insert is greater than a width of the insert. Related devices, systems, and methods are provided.

The utility model relates to the technical field of medical instruments, and provides an eyeball surface flushing unit and a flusher, the flushing unit comprises a needle seat and a hollow needle tube, the needle tube comprises a flushing end and a connecting end, the connecting end is connected with the needle seat, the cross section of the needle tube is oval or kidney-round, the long axis of the cross section is 1.4-3mm, and the short axis of the cross section is 1.0-2mm. And the end part of the flushing end of the needle tube is blunt and flat. A trumpet-shaped flushing part is arranged at the flushing end of the needle tube, and a flushing opening of the flushing part is oval or kidney-shaped. And the length of the needle tube is 3-5cm. The needle tube has the advantages that the size of the hole of the needle tube is larger than that of a traditional needle tube, water flow is thicker, compared with traditional thin water flow, the impact force of the water flow is smaller, the situation that the water flow is splashed to pollute the full retinoscope and form water drops due to too large impact force of the water flow is avoided, the view of an operator cannot be affected, and smooth operation is guaranteed. In addition, the oval section is combined, water flow is flattened, and the flushing effect is better compared with a circular design.