21 results about "Artificial cornea" patented technology

The present disclosure relates to a support element (10) for an artificial cornea, the support element being disc-shaped and concentric with a central axis (P) and comprising: a central region (101) and a perimetral (102) region adjacent to a perimeter edge of the support element, the central region comprising a convex face (1011), a concave face (1012) opposed to each other and one central through hole (103) concentric with the central axis; wherein the perimetral region is flared, the surface of the support element is coated with silver, and at least the concave face of the support element comprises a peptide or a pharmaceutical salt thereof attached therein. The present disclosure also relates to an artificial cornea comprising the support element described.

This invention discloses an artificial corneal endothelial graft based on natural degradable proteins, its preparation method, and its application, relating to the field of medical implant materials technology. Currently, artificial corneal endothelial grafts for corneal endothelial decompensation are all non-degradable synthetic polymer materials. This invention uses a natural degradable material as the substrate to prepare the graft. A material preparation stock solution is obtained by mixing a silk fibroin solution extracted from a high-salt solution with a certain proportion of glycerol. The mixed solution is then spin-coated onto a mold using a gradient method, and dried to obtain a silk fibroin film. The obtained silk fibroin film is then circumcised and placed in a mold for hot-press steam fumigation. The resulting silk fibroin film can serve as an artificial corneal endothelial graft, providing a donor source for artificial corneas and possessing potential application value in corneal transplantation.

The application discloses a composite artificial cornea and a preparation method thereof. The composite artificial cornea comprises a mirror column and a biological skirt. An annular gap is arranged on the inner side edge of the biological skirt. The outer side edge of the mirror column is embedded into the inside of the biological skirt along the gap, and the outer side edge of the mirror column is fixed in the gap through casting liquid. The application has the beneficial effects that: by arranging the annular gap on the inner side edge of the biological skirt, then embedding the outer side edge of the mirror column into the inside of the biological skirt along the gap, a interference fit structure is formed, preliminary fixation is formed between the mirror column and the gap, and the outer side edge of the mirror column is fixed in the gap through the casting liquid, so that the casting liquid can permeate and fill the gap, the mirror column and the biological skirt are connected into an integrated whole, secondary fixation is formed, the connection strength of the composite artificial cornea is improved, and the risk of the mirror column falling off is reduced.

The clamping type artificial cornea comprises a lens column body, a curved surface disc used for being attached to the rear surface of a cornea body is coaxially arranged on the outer ring face, close to the rear end, of the lens column body, a guide hole is formed in the curved surface disc, and the circumferential thickness of the curved surface disc is gradually increased from the center to the edge; the lens column body is detachably connected with a curved surface support matched with the curved surface disc, and the curved surface support is fixed in a sewing mode so as to be attached to the front surface of a cornea body. The curved surface disc is used for clamping a curved sample of a cornea body on the curved surface bracket; through cooperation of the curved-surface support and the curved-surface disc and the guide holes in the curved-surface disc, the cornea is clamped in a non-closed mode, the cornea can be clamped more conveniently, abrasion of the cornea body is reduced, the installation stability of the artificial cornea can be improved, the dead weight of the artificial cornea is reduced, and therefore it is guaranteed that the cornea can not be damaged along with the increase of wearing time. The installation position of the artificial cornea is not prone to deviation, and normal use is guaranteed.

The application discloses an umbrella-shaped mirror column-based artificial cornea, which comprises a support and a mirror column connected with the support, wherein the support comprises a main body structure in a spherical surface structure, a middle part of the main body structure is provided with an opening, the mirror column is arranged in the opening, a micro-porous gap is formed on the circumferential surface of the main body structure, the top end surface of the mirror column is formed in an arc-shaped umbrella structure, and the bottom end surface of the mirror column is formed in a concave spherical surface structure. The application further discloses a preparation process of the artificial cornea. The artificial cornea is provided with the micro-porous gap on the circumferential surface of the main body structure, so that the healing tissue can pass through the micro-porous gap, the combination force between the support and the cornea is increased, and the stability is improved. In addition, the arc-shaped umbrella structure formed on the top end surface of the mirror column can prevent the growing tissue from covering the mirror surface of the mirror column in the later use of the patient, the light can enter the mirror column, the optical function can be normally played, and the occurrence of the anterior membrane complication is reduced.

The application discloses a kind of methacrylic acid succinic acid double ester starch and its preparation method and application in corneal defect in situ filling agent, belong to the technical field of biomedical materials.The methacrylic acid succinic acid double ester starch is grafted carboxylation treatment to starch, then graft double bond is prepared.The corneal defect in situ filling agent of the application is composed of methacrylic acid succinic acid double ester starch (StacMA), methacrylated gelatin (GelMA), photo initiator and solvent.The natural biological macromolecule based corneal filling agent of starch and gelatin in the application has good biocompatibility, excellent light response adhesion characteristics and excellent mechanical properties, and the in-situ photocrosslinking of hydrogel is realized by ultraviolet irradiation, while excellent mechanical properties and strong adhesion capacity are generated, to realize the stable adhesion of in-situ forming artificial cornea on corneal implant bed, promote the regeneration of damaged corneal natural structure and the reconstruction of visual function.

The application provides a method for constructing a tissue-engineered cornea based on human amniotic epithelial stem cells and application thereof, and belongs to the technical field of biotechnology. The method comprises the following steps: 1) culturing human amniotic epithelial stem cells in a corneal epithelial cell induction and differentiation culture medium to obtain human corneal epithelial cell-like cells; culturing the human amniotic epithelial stem cells in a corneal stromal cell induction and differentiation culture medium to obtain corneal stromal cells; 2) inoculating the human corneal epithelial cell-like cells and the corneal stromal cells obtained in step 1) on the surface and inside of a decellularized corneal stromal scaffold respectively, and co-culturing for 5 days to construct a tissue-engineered cornea. The application successfully constructs a tissue-engineered cornea by inoculating two kinds of corneal cells derived from human amniotic epithelial stem cells on a human decellularized corneal stromal at the same time for the first time. In addition, the obtained corneal cells can be inoculated on various types of biomaterials such as hydrogels, thereby providing a wider application possibility for developing various types of artificial cornea products.

The invention relates to an artificial corneal endothelium sheet as well as a preparation method and application thereof. The artificial corneal endothelium sheet is prepared from the following raw materials: a hydrophilic monomer, a hydrophobic monomer, a cross-linking agent, an ultraviolet absorption monomer, a blue light absorption monomer and an initiator, the hydrophilic monomer comprises a combination of hydroxyethyl methylacrylate and polyethylene glycol methacrylate, and the hydrophobic monomer comprises a combination of methyl methacrylate and isobutyl methacrylate; in the preparation raw materials, the use amount of the hydrophilic monomer is 80-94 wt%, and the use amount of the hydrophobic monomer is 5-19 wt%. According to the artificial corneal endothelium sheet provided by the invention, the proportion and components of the hydrophilic monomer and the hydrophobic monomer are regulated and controlled, so that the obtained artificial corneal endothelium sheet is moderate in water content and has excellent mechanical properties, adhesion performance and swelling stability.

A keratoprosthesis (100), comprising a support (10) and a lens column (30), the lens column (30) comprising a body (31) and a collar (32). A middle part of the support (10) is provided with a mounting hole (10A), a hole wall of which being provided with an internal thread (111), and the outer peripheral wall of the collar (32) being provided with an external thread (321) fitting with the internal thread (111), so as to detachably assemble the support (10) and the collar (32). The material of the body (31) is polymethyl methacrylate, so as to provide a reliable light path structure, and the collar (32) is titanium metal. The body (31) and the collar (32) are integrally formed, such that the collar (32) is sleeved on the body (31) so as to form a lens column (30), and the outer peripheral wall of the body (31) is provided with a limiting slot (31D) for limiting the collar (32). The support (10) is titanium metal, such that the internal thread (111) and the external thread (321) are metal threads of the same material, and the heat shrinkage ratios of structures of the same material undergoing a temperature change are the same, so that a joint has a high assembly reliability and does not separate or fall off unless an external force is applied thereto. The service life of the artificial cornea is increased, surgical risks are reduced, a patient is protected from secondary injury or being blinded again, and use satisfaction is increased.

The present disclosure relates to a method of manufacturing a keratoprosthesis exhibiting excellent physical properties by stabilizing the interface of an adhesive optical unit and a support unit through a keratoprosthesis mold and UV dose adjustment. The present disclosure can stably adhere an interface between the optical unit and the support unit by manufacturing the optical unit for 1-4 hours using low dose UV in the keratoprosthesis mold, thereby manufacturing the keratoprosthesis in which the optical unit and the support unit are integrated. The artificial cornea manufactured by the manufacturing method has a constant spherical shape and is convenient for center positioning, so that the success rate of an operation can be improved during the operation; the central part of the optical unit shows uniform and excellent physical properties, so that the physical safety in a human body can be further improved; moreover, the interface of the optical unit and the support unit shows excellent physical properties which are equivalent to about 100 times of the existing intraocular pressure, so that the separation of the optical unit and the support unit caused by intraocular pressure in the human body can be prevented at an early stage. Furthermore, by means of the manufacturing method, the eye appearance of a patient to which the artificial cornea is transplanted can be improved, and complications and side effects caused by adhesive substances can be reduced.

The invention discloses rotary fixing tweezers for assembling an artificial cornea and a using method of the rotary fixing tweezers, and belongs to the technical field of medical precision instruments. When the lens column of the artificial cornea and the support are assembled, the rotary fixing tweezers are used for clamping the lens column. When the cylinder is rotated, force is transmitted to the tweezers body through the spring, the tweezers body is driven to rotate, meanwhile, the length of the spring changes, and meanwhile the size of the force borne by the spring is visually displayed through scales. The rotary fixing tweezers for assembling the artificial cornea have the functions of clamping the lens column and rotating the lens column.

This invention belongs to the field of medical device technology and discloses an artificial cornea, including a lens column and a support. The support has a mounting hole in its center, and the lens column is installed within the mounting hole. Both the front and rear surfaces of the lens column protrude outwards from the mounting hole. The front surface of the lens column is convex, and the rear surface is concave. The rear surface of the lens column is closer to the retina, while the front surface is further away from the retina. The rear surface of the support has an annular guide groove that surrounds the lens column. The annular guide groove guides the movement trajectory of surgical instruments and maintains a preset distance from the lens column. The support also has multiple fixing holes that penetrate the support from front to back, surrounding the annular guide groove. This artificial cornea can be transplanted into patients with mild to moderate corneal blindness, replacing the diseased cornea in mild to moderate cases. It effectively fills the treatment gap in the field of mild to moderate corneal blindness, reduces the risk of iatrogenic injury and complications, and solves the problem of severe donor shortage.

The invention discloses a method for analyzing influence of a suture boundary on keratoprosthesis optical imaging, which adopts a method of combining human eye finite element model simulation and human eye optical model simulation, analyzes the effect of the suture boundary on the keratoprosthesis through a finite element model, and can obtain stress response and configuration change of the keratoprosthesis in real time with high efficiency and low cost. And the final imaging effect of the operation can be simulated in real time by combining a human eye optical model. The mechanical-optical double-path hybrid network of the artificial cornea is established, personalized parameter adjustment is provided for an operation according to the postoperative requirements of a patient, the operation effect is optimized, and the postoperative visual recovery quality and precision of the patient can be finally improved.

According to one aspect of the present invention, a composition for an artificial corneal scaffold comprises a 2-hydroxyethyl methacrylate (HEMA) monomer and a methyl methacrylate (MMA) monomer, wherein the molar ratio of the 2-hydroxyethyl methacrylate (HEMA) monomer and the methyl methacrylate (MMA) monomer can be 83:17 to 97:3. In addition, according to one aspect of the present invention, an artificial corneal scaffold and an artificial cornea can be prepared by polymerization of the composition for an artificial corneal scaffold.

This invention discloses an integrated artificial cornea and its preparation method, belonging to the field of biomedical engineering technology. The artificial cornea comprises a main corneal layer and a posterior corneal layer. The main corneal layer includes a central optical zone, a transitional junction zone, and a decellularized corneal annular zone. The main corneal layer uses a decellularized cornea as its overall framework. Polymerizable monomers are introduced into the decellularized corneal stroma and then cured using in-situ gradient curing technology. The integrated artificial cornea provided by this invention uses a decellularized cornea as its overall framework, eliminating the need for central perforation, resulting in better morphological stability. The optical zone constructed using gradient curing technology provides a favorable environment for cell ingrowth, promoting healing between the transplanted tissue and the corneal graft material.

A PVA hydrogel-based artificial cornea and a preparation method therefor. The artificial cornea comprises an optical center part and a skirt support, wherein the optical center part comprises a composite PVA hydrogel based on PVA and amino acid / caffeic acid modified chitosan; and the skirt support comprises PVA, amino acid / caffeic acid modified chitosan, nanophosphate, and polyethylene glycol hydroxy acid. The prepared artificial cornea has sufficient optical properties, excellent mechanical properties, good biocompatibility and infection resistance, reduced occurrence of post-implantation complications, and high safety.

The application discloses a customized collagen modified hydrogel and a preparation method and application thereof, and belongs to the field of biomedical materials. The material is formed by co-polymerization and cross-linking of customized collagen, hydrogel polymer monomers, a cross-linking agent and an initiator, wherein the customized collagen is recombinant human type I collagen with carbon-carbon double bonds or human amniotic membrane extract with carbon-carbon double bonds. The customized collagen modified hydrogel disclosed by the application can be used for preparing intraocular lenses and artificial corneal endothelium, and can greatly reduce the adhesion of proteins and macrophages while meeting the mechanical and optical performance requirements of the ophthalmic implant materials such as intraocular lenses and artificial corneal endothelium, and can potentially prolong the service life of the ophthalmic implant materials such as intraocular lenses and artificial corneal endothelium, and has a wide application prospect in ophthalmic implant materials.

The application belongs to the technical field of biomaterial preparation, and particularly relates to a polyvinyl alcohol biomimetic cornea and application thereof. The biomimetic cornea is prepared according to the following steps: after polyvinyl alcohol solution is cast into a film, pre-stretching, drying and water absorption are performed to obtain a single-layer hydrogel with fiber orientation; a plurality of the hydrogels with fiber orientation are stacked in a 90-degree orthogonal manner between adjacent layers, and polyvinyl alcohol solution is injected between the layers as an adhesive layer, and the obtained sample is subjected to multiple freeze-thaw cycles to form a multi-layer orthogonal structure hydrogel with a cornea-imitating structure. The application successfully prepares a polyvinyl alcohol biomimetic cornea with high strength, high transparency, good biocompatibility and excellent puncture resistance by pre-stretching induced orientation and multi-layer orthogonal structure design, and overcomes the contradiction between the mechanical properties and optical properties of the existing hydrogel materials, thereby providing an ideal candidate material for the clinical conversion of artificial corneas.

The invention relates to the technical field of medical instruments, and particularly discloses an artificial corneal endothelium sheet which comprises a main body part and an extension part, the main body part is in a vault shape, and the outer diameter of the main body part is larger than or equal to the diameter of a pupil; the plurality of extension parts are arranged on the periphery of the main body part at intervals; each extension part is in an arc-shaped strip shape, the radian of the extension parts is the same as that of the main body part, the width of the extension parts is gradually reduced in the direction away from the center point of the main body part, and a notch is formed between any two adjacent extension parts. The stability of the artificial corneal endothelium sheet is improved.

The invention belongs to the technical field of medical instruments and discloses an artificial cornea which comprises a lens column and a support, a mounting hole is formed in the middle of the support, the lens column is mounted in the mounting hole, the front surface and the rear surface of the lens column protrude out of the mounting hole outwards, the front surface of the lens column is a convex surface, the rear surface of the lens column is a concave surface, and the rear surface of the lens column is a surface close to the retina. The front surface of the lens column is a surface far away from the retina, an annular guide groove is formed in the rear surface of the support, surrounds the lens column and is used for guiding the motion trail of a surgical instrument, a preset distance is kept between the annular guide groove and the lens column, and a plurality of fixing holes penetrating through the support front and back are further formed in the support. And the plurality of fixing holes are arranged around the annular guide groove. The artificial cornea disclosed by the invention can be transplanted into the body of a patient suffering from light and medium corneal blindness to replace a lesion cornea suffering from light and medium corneal blindness, so that the treatment blank in the field of the light and medium corneal blindness is effectively filled, the iatrogenic injury and complication risk are reduced, and the problem of serious shortage of donors is solved.

This invention discloses a sutureless composite artificial cornea, comprising a polymer posterior membrane and a biological anterior membrane fixed to the anterior surface of the polymer posterior membrane. The biological anterior membrane is divided into a central zone and a peripheral zone. The peripheral zone contains several radially arranged tunnels, with the head end of each tunnel located on the upper surface of the peripheral zone and the tail end located at the outer edge of the peripheral zone. Each tunnel contains a pre-embedded tissue fixation guidewire, and the length of the tissue fixation guidewire is greater than the length of the tunnel. The advantages of this invention are: by setting radial tunnels within the peripheral zone of the biological anterior membrane and pre-embedding tissue fixation guidewires within the tunnels, during surgery, the tissue fixation guidewires are pushed in along the tail end of the tunnels, allowing them to be inserted into the corneal implant bed, achieving fixation between the cornea and the corneal implant bed. This avoids corneal astigmatism caused by suturing and simplifies the surgical procedure.