6 results about "Tissue necrosis" patented technology

The application relates to the technical field of aquatic virus prevention and treatment, and particularly discloses application of YTX in preparation of a medicine for preventing and treating SCRV infection. The application verifies the prevention and treatment effects of YTX on SCRV infection through fish body level experiments. The experimental results show that, in a safe concentration range, YTX can significantly improve the survival rate of fish after SCRV infection by being administered through soaking or injection, the relative protection rate is more than 85%; the virus load in target organs such as kidneys and spleens is significantly reduced, the virus copy number is reduced by 2-3 logarithmic levels; and the pathological damage such as tissue necrosis and inflammatory infiltration caused by the virus is effectively reduced. The application verifies the anti-SCRV effect of YTX at the fish body level for the first time, provides key data support for development and application of YTX as a new aquatic antiviral preparation, and has important industrial application value.

This invention provides a flow-limiting device, comprising a support, a fixed membrane, a movable membrane, and a side membrane. The fixed membrane surrounds the inner side of the support and is fixedly connected to the support. The movable membrane can axially approach or move away from the fixed membrane. The side membrane connects the fixed membrane and the movable membrane and has multiple connecting holes. The opening area of ​​the connecting holes can be adjusted according to the fluid flow, allowing the flow-limiting device to switch between a first state, a second state, and a third state. In the first, third, and second states, the distance between the movable membrane and the fixed membrane gradually decreases, and the opening area of ​​the connecting holes gradually decreases. When the flow-limiting device is in the third state, it can reduce rapid blood reflux, thus limiting blood flow and reducing the probability of tissue necrosis caused by excessively rapid blood reflux.

This invention belongs to the field of medical device technology and discloses an integrated multi-module textile flexible urinary control device with oxygen saturation monitoring. It includes an integrated flexible textile support body, a flexible textile skin-friendly layer, a urinary control core component, and an oxygen saturation measuring device. The integrated flexible textile support body comprises a double-layer fabric unit A and a double-layer fabric unit B. Both double-layer fabric units A and B are formed using a machine-woven process, with weft yarns selectively passing through a portion of the warp yarns, and each consists of an upper and lower fabric layer. The flexible textile skin-friendly layer is made using a non-woven hydroentangling process and is fixed to the inner surface of the integrated flexible textile support body. The urinary control core component is located between the upper and lower fabric layers of double-layer fabric unit A. The oxygen saturation measuring device is located between the upper and lower fabric layers of double-layer fabric unit B. This invention, by monitoring oxygen saturation in real time, allows patients to adjust to a suitable pressure, preventing tissue necrosis.

The application relates to the field of biological medicine, and discloses a use of indole-3-propionic acid in preparation of a medicine for preventing and treating acute-on-chronic liver failure. Experiments prove that the indole-3-propionic acid can effectively inhibit the formation of neutrophil-related extracellular traps, reduce the levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin and inflammatory factors TNF-alpha, IL-6 and IL-1beta related to acute-on-chronic liver failure, reduce liver tissue necrosis and inflammatory infiltration, and improve the survival rate. Therefore, the indole-3-propionic acid can be used for preparing a medicine for preventing and / or treating acute-on-chronic liver failure, and provides a new small-molecule intervention strategy for acute-on-chronic liver failure.

This application belongs to the field of skin injury image assessment technology, specifically providing a method and system for assessing skin injury caused by chemotherapy drug extravasation. The method mainly includes: acquiring a multispectral image of the affected area; acquiring a damage reference spectral vector representing typical drug-induced damage characteristics; based on the damage reference spectral vector, performing orthogonal projection decomposition on the spectrum of each pixel in the multispectral image to generate a projection component image and a spectral residual image; extracting the local texture pattern of the spectral residual image to generate a residual texture map for quantifying the heterogeneity of tissue microstructure. This application effectively solves the problem in existing technologies where early drug extravasation injury and subcutaneous bruising are difficult to accurately distinguish under conventional visual conditions, easily leading to clinical misjudgment and delayed intervention. It enables early warning of the risk of early, occult tissue necrosis caused by chemotherapy drug extravasation, thereby potentially reducing the incidence of severe tissue damage.

This invention discloses the application of DNA methyl donors in the preparation of drugs for treating severe acute pancreatitis and / or its complications, as well as a method for screening candidate drugs. The application of DNA methyl donors provided by this invention in the preparation of drugs for treating severe acute pancreatitis and / or its complications, by supplementing the methyl donor, restores the methylation level of the Foxp1 enhancer, blocks the "FOXP1-CXCR4" axis upstream, significantly reduces pancreatic microthrombus formation and alleviates tissue necrosis, and avoids the systemic side effects of directly antagonizing CXCR4.