22 results about "Tissue necrosis" patented technology

Use of a composition comprising bacteria for odor reduction in the treatment of symptoms of tissue necrosis, wound secretions or putrid wounds or a disease selected from the group consisting of ozena, hyperhidrosis, osmidrosis, chronic urinary tract infections, chlamydial infections and halitosis; wherein the composition comprises the bacteria Lactobacillus acidophilus TYCA15, Lactobacillus salivarius, Bifidobacterium animalis, Bifidobacterium bifidum and Bifidobacterium longum in the ratio 1:1:1:1:1; and the composition totals 10 9 bacteria per gram of the composition.

The utility model discloses a novel circumcision anastomat which comprises an inner ring and an outer ring, the inner ring is used for supporting the inner side of a prepuce, the outer ring is composed of a pair of outer ring lock catches which can be mutually locked, a dull knife is arranged on the inner side of each outer ring lock catch, a drainage assembly is arranged on each dull knife, and the outer ring lock catches are buckled on the outer side of the inner ring. The blunt knife extrudes the foreskin tissue on the outer side of the inner ring, the to-be-cut tissue and the reserved tissue are isolated through the arranged inner ring and the locking mechanism, so that the to-be-cut tissue necroses and falls off, then cutting is completed, in addition, tissue fluid is guided out to be away from the isolation belt through the drainage assembly, and it is guaranteed that the position nearby the tissue fluid is kept dry; lymph accumulation and flowing around are avoided, and cross infection is reduced, so that edema is relieved, and healing is faster.

The application relates to the technical field of aquatic virus prevention and treatment, and particularly discloses application of YTX in preparation of a medicine for preventing and treating SCRV infection. The application verifies the prevention and treatment effects of YTX on SCRV infection through fish body level experiments. The experimental results show that, in a safe concentration range, YTX can significantly improve the survival rate of fish after SCRV infection by being administered through soaking or injection, the relative protection rate is more than 85%; the virus load in target organs such as kidneys and spleens is significantly reduced, the virus copy number is reduced by 2-3 logarithmic levels; and the pathological damage such as tissue necrosis and inflammatory infiltration caused by the virus is effectively reduced. The application verifies the anti-SCRV effect of YTX at the fish body level for the first time, provides key data support for development and application of YTX as a new aquatic antiviral preparation, and has important industrial application value.

The invention belongs to the technical field of biological medicines, and particularly relates to a temperature-sensitive hydrogel delivery system based on antibacterial peptide engineered watermelon-derived extracellular vesicles as well as a preparation method and application of the temperature-sensitive hydrogel delivery system. The preparation method comprises the following steps: by taking 3, 4-dihydroxy-L-phenylalanine, namely DOPA, as a connecting body, connecting antibacterial peptide AMP and watermelon-derived extracellular vesicles wEV into wEV-AMP, and then mixing PF127 with CS to prepare a temperature-sensitive hydrogel delivery system carrying wEV-AMP; the sequence of the antibacterial peptide is a GL13K sequence, and is as shown in SEQ ID NO. 1. The system can effectively promote proliferation and migration of fibroblasts and regulate and control expression of inflammatory factors while resisting bacterial infection. In a rat back full-thickness skin defect model infected by staphylococcus aureus, the compound also shows comprehensive advantages of accelerating healing and reducing tissue necrosis and inflammatory response; the engineered hydrogel system shows good treatment potential in infectious wound treatment, and provides reference for repair of soft tissue injury under various conditions.

The application discloses a head compression tourniquet, and relates to the technical field of medical auxiliary instruments, which comprises a compression band, and a plurality of annular main adjusting air bags are arranged on the inner side wall of the compression band. The setting of the triangular block, the rotating shaft, the connecting plate, the U-shaped rod, the first wedge-shaped block, the second wedge-shaped block, the limiting rod and the adjusting spring realizes automatic switching of the compression position of the patient while guaranteeing the hemostasis effect, avoids problems such as blood vessel adhesion, end tissue necrosis and the incapability of growing hair caused by the compression of the same position for a long time during a craniotomy operation, and the setting of the pressure relief valve enables the self-adaptive adjustment of the inflation amount of the head circumference of different positions of the head during the switching of the auxiliary air bag, so that the same pressure effect of the head is maintained during the switching of the auxiliary air bag, the problems of insufficient pressure and massive bleeding of the wound do not occur, and the problem of excessive pressure and the occlusion of the blood vessels of the patient to form thrombus does not occur.

A wound pressurizing device used after brachial plexus release comprises a tile-shaped shoulder wrapping plate and a fixing bandage used for the shoulder wrapping plate, plate-shaped outer inflatable cushions are arranged on the front side and the back side of the inner side face of the shoulder wrapping plate respectively, and plate-shaped inner inflatable cushions are arranged on the upper portion and the lower portion of the shoulder contact face of the outer inflatable cushion on each side respectively. The inner inflatable cushions are smaller than the outer inflatable cushions, and the outer inflatable cushions and the inner inflatable cushions are connected and communicated with air outlets corresponding to external electromagnetic exhaust valves through inflation hoses respectively. The pressurizing force can be adjusted, the pressurizing device is better suitable for wound pressurizing after brachial plexus debonding, local pressurizing is more targeted, some small blood vessels are closed, the risk of further bleeding is reduced, and rapid hemostasis of wounds is facilitated; the elastic bandage has certain buffering elasticity, and proper pressure is adopted to promote blood circulation of local tissues, accelerate the wound healing process and reduce the risk of tissue necrosis.

The invention relates to a device (17) for treatment of body tissue, in particular for the permanent occlusion of varicose veins, preferably in the lower limbs, of varicocele and / or of vascular malformations and / or for the use in aesthetic surgeries, preferably laser assisted lipolysis, and / or for tumor treatment by means of laser induced thermotherapy and / or photodynamic therapy, and / or in particular for the irradiation of brain tissue, for ear-nose-throat applications, in particular necrosis of tissue, for surface disinfection by laser light, for dermatologic treatment, including application on skin and / or nails and / or for treatment of pilonidal sinus, anal fistula and / or hemorrhoids, by means of a light diffuser (13) for irradiating said tissue by laser light energy and / or by electromagnetic radiation, wherein the light diffuser (13) is designed to irradiate the radiation laterally with respect to a longitudinal center axis of the light diffuser (13) and endoluminally. According to the invention, a sliding layer (51) is provided on an outer surface, in particular the outermost surface, of a distal end of the diffuser (13) at least in certain regions, preferably in the region of the front distal end of the diffuser (13) and / or in the region of the energy emission of the diffuser (13), in particular completely, in particular to reduce friction with and / or in particular to reduce adhesion to said surrounding tissue.

This invention provides a flow-limiting device, comprising a support, a fixed membrane, a movable membrane, and a side membrane. The fixed membrane surrounds the inner side of the support and is fixedly connected to the support. The movable membrane can axially approach or move away from the fixed membrane. The side membrane connects the fixed membrane and the movable membrane and has multiple connecting holes. The opening area of ​​the connecting holes can be adjusted according to the fluid flow, allowing the flow-limiting device to switch between a first state, a second state, and a third state. In the first, third, and second states, the distance between the movable membrane and the fixed membrane gradually decreases, and the opening area of ​​the connecting holes gradually decreases. When the flow-limiting device is in the third state, it can reduce rapid blood reflux, thus limiting blood flow and reducing the probability of tissue necrosis caused by excessively rapid blood reflux.

The invention relates to the technical field of fistulization devices, in particular to an ileum fistulization device with a stoma monitoring function, which comprises a fixed chassis, a covering assembly and a monitoring assembly. The monitoring assembly comprises a fixing ring; an electrode plate and a photoelectric sensor are arranged at the bottom of the fixing ring; an electric control assembly is arranged on the fixing ring and electrically connected with the electrode plates and the photoelectric sensor through wires. According to the invention, leakage monitoring and ischemia early warning functions are integrated, tissue impedance can be measured through the electrode slice, and leakage can be accurately identified. Meanwhile, the photoelectric sensor is used for monitoring the blood oxygen saturation degree, the oppression ischemia condition can be found in time, and stoma tissue necrosis is prevented. According to the invention, seepage and ischemia states can be monitored in advance according to monitoring data, and the problem that detection and alarm can only be carried out after certain serious consequences are generated by a transmission monitoring device is avoided. The skin injury and infection risk caused by leakage or ischemia of a patient can be remarkably reduced, and the use comfort and life quality of the patient are improved.

This invention belongs to the field of medical device technology and discloses an integrated multi-module textile flexible urinary control device with oxygen saturation monitoring. It includes an integrated flexible textile support body, a flexible textile skin-friendly layer, a urinary control core component, and an oxygen saturation measuring device. The integrated flexible textile support body comprises a double-layer fabric unit A and a double-layer fabric unit B. Both double-layer fabric units A and B are formed using a machine-woven process, with weft yarns selectively passing through a portion of the warp yarns, and each consists of an upper and lower fabric layer. The flexible textile skin-friendly layer is made using a non-woven hydroentangling process and is fixed to the inner surface of the integrated flexible textile support body. The urinary control core component is located between the upper and lower fabric layers of double-layer fabric unit A. The oxygen saturation measuring device is located between the upper and lower fabric layers of double-layer fabric unit B. This invention, by monitoring oxygen saturation in real time, allows patients to adjust to a suitable pressure, preventing tissue necrosis.

The present disclosure proposes a kit (100) and composition for treating edema, necrotizing fasciitis, restoring muscle perfusion, and limiting bacterial spread. The kit (100) comprises a topical antibiotic cream (102), plurality of antiseptic gauzes (104), an ordho cloth roller bandage (106), a crepe roller (108), a super absorbent gamjee roller (110), and a pair of surgical gloves (112). The proposed kit (100) treats edema of any type, including prevention of death through early intervention, avoiding surgery, minimizing morbidity, and reducing patient expenditure. The proposed kit (100) decreases muscle compartment pressure, increases blood flow to affected muscles, and prevents tissue necrosis. The proposed kit (100) significantly reduces patient expenditure compared to conventional treatments, making it affordable for a broader population.

The utility model belongs to the field of injection needles, particularly relates to a pumpable double-cavity injection needle device, and aims to solve the problems that an existing hyaluronic acid injection needle is provided with a single cavity, whether the needle is placed in a blood vessel or not cannot be clearly confirmed before injection, so that an injection object is possibly injected into the blood vessel by mistake, and adverse complications such as tissue necrosis are caused by vascular embolism. According to the scheme, the device comprises a blood return needle cylinder, a medicine injection needle cylinder is fixedly arranged in the blood return needle cylinder, the front end of the blood return needle cylinder is in threaded connection with a connector, the connector is communicated with the blood return needle cylinder, one side of the connector is fixedly communicated with a blood return needle tube, and a medicine injection channel is fixedly arranged in the blood return needle tube. Through the arrangement of the double-cavity needle cylinder and the double-cavity needle tube, whether the needle head is in a blood vessel or not can be determined before injection, so that bad complications such as tissue necrosis and the like caused by the fact that liquid medicine is injected into the blood vessel due to the improper position of the needle head are avoided.

The asymmetric anastomosis nail comprises a nail body and nail feet, the heights of the two nail feet are different, and after the two nail feet are bent and formed, a notch is formed between the shorter nail foot and the nail body after the shorter nail foot is bent; the nail bin assembly comprises a nail bin seat and a nail abutting seat, a nail storage groove is formed in the nail bin seat, a sewing nail is arranged in the nail storage groove, a forming groove used for enabling the two ends of the sewing nail to be bent inwards is formed in the face, close to the nail bin seat, of the nail abutting seat, a receding groove allowing the cutting knife to penetrate through is further formed in the nail bin seat, and the receding groove is located in the middle of the nail bin seat in the width direction. Six rows of staple storage grooves are formed, the two sides of the receding groove correspond to three rows of staple storage grooves respectively, the staples in the two rows of staple storage grooves, close to the receding groove, of each side of the receding groove are asymmetric anastomotic staples, and the staples in the row of staple storage grooves, farthest from the receding groove, of each side of the receding groove are symmetric anastomotic staples. The anastomat has the effects that the percussion resistance of the anastomat is reduced, and the necrosis of suture tissue is reduced.

The application provides an external artificial urethral sphincter device, adopts an external double air bag pressure control structure design, adjusts the size of the pressure of the air bag on the urethra by controlling the size of the inflation amount of the air bag, and realizes free urine control. Through the double air bag integrated design, the volume of the device is reduced, the device is convenient to carry, the image of the patient is maintained during use, and the experience of the patient is improved. The external artificial urethral sphincter device saves the cost of the artificial urethral sphincter implantation surgery and reduces the economic pressure of the patient. In addition, the structure of the external artificial urethral sphincter device is similar to the shape of the penis, when inflated, the extrusion force generated on the two sides of the air bag for fixing the penis is offset by the force for extruding the air bag, the aorta of the penis is prevented from being extruded, and tissue necrosis is prevented.

The application relates to the field of biological medicine, and discloses a use of indole-3-propionic acid in preparation of a medicine for preventing and treating acute-on-chronic liver failure. Experiments prove that the indole-3-propionic acid can effectively inhibit the formation of neutrophil-related extracellular traps, reduce the levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin and inflammatory factors TNF-alpha, IL-6 and IL-1beta related to acute-on-chronic liver failure, reduce liver tissue necrosis and inflammatory infiltration, and improve the survival rate. Therefore, the indole-3-propionic acid can be used for preparing a medicine for preventing and / or treating acute-on-chronic liver failure, and provides a new small-molecule intervention strategy for acute-on-chronic liver failure.

The invention provides an application of selenium-rich probiotics in preparation of a preparation for treating fluoxetine-induced liver injury, and relates to the technical field of biological medicine, the application is characterized in that Se-BL is obtained by reducing sodium selenite through ascorbic acid and modifying the surface of bifidobacterium longum, and nano-scale selenium dots are formed. The preparation plays a role through dual mechanisms: active oxygen (ROS) is directly removed, an Nrf2 pathway is activated, and the liver oxidation resistance (GSH, SOD) is improved; the traditional Chinese medicine composition is capable of inhibiting NF-kappa B inflammation signal channels, reducing proinflammatory factors (TNF-alpha and IL-6) and synchronously regulating intestinal flora so as to enhance the intestinal barrier function. Experiments prove that the traditional Chinese medicine composition can remarkably reduce the level of serum transaminase (ALT / AST / ALP) and relieve liver tissue necrosis and lipid peroxidation damage (MDA), the dosage form of the traditional Chinese medicine composition is an oral preparation, and each dose of the traditional Chinese medicine composition contains 1 * 10 <-1 > * 10 <-1 > CFU of Se-BL viable bacteria. The selenium-modified probiotics are used for antagonizing hepatotoxicity of mental drugs for the first time, and an innovative therapy is provided for fluoxetine-induced drug-induced liver injury (DILI) and acute hepatic failure (ALF).

The application provides a DNA tetrahedral framework nucleic acid and FG-4592 complex, a preparation method and use thereof, and belongs to the field of biological medicines.The DNA tetrahedral framework nucleic acid and FG-4592 complex is a complex formed by mixing a DNA tetrahedral framework nucleic acid and FG-4592.The DNA tetrahedral framework nucleic acid and FG-4592 have the synergistic effect of reducing apoptosis of renal cortical proximal tubular epithelial cells, reducing kidney tissue necrosis, restoring kidney function, and preventing and treating renal fibrosis and preventing the development of acute kidney injury into chronic kidney disease, thereby providing a new option for clinical treatment.

This application belongs to the field of skin injury image assessment technology, specifically providing a method and system for assessing skin injury caused by chemotherapy drug extravasation. The method mainly includes: acquiring a multispectral image of the affected area; acquiring a damage reference spectral vector representing typical drug-induced damage characteristics; based on the damage reference spectral vector, performing orthogonal projection decomposition on the spectrum of each pixel in the multispectral image to generate a projection component image and a spectral residual image; extracting the local texture pattern of the spectral residual image to generate a residual texture map for quantifying the heterogeneity of tissue microstructure. This application effectively solves the problem in existing technologies where early drug extravasation injury and subcutaneous bruising are difficult to accurately distinguish under conventional visual conditions, easily leading to clinical misjudgment and delayed intervention. It enables early warning of the risk of early, occult tissue necrosis caused by chemotherapy drug extravasation, thereby potentially reducing the incidence of severe tissue damage.

The utility model relates to a thrombus filtration system, the thrombus filtration system comprises a delivery device and a filtration device, the delivery device comprises a connecting piece, a handle assembly and a sheathing canal, the handle assembly comprises a sliding assembly, the near end of the sheathing canal is connected with the sliding assembly, and the filtration device is connected with the connecting piece. The near end of the connecting piece penetrates through the near end of the sheathing canal and then is fixed in the handle assembly, the far end of the connecting piece is connected with the filtering device, the filtering device can be contained in the far end of the sheathing canal, and the sliding assembly can drive the sheathing canal to move relative to the connecting piece and the filtering device. The thrombus filtering system can intercept and capture fallen thrombus or calcification fragments in the operation process so as to prevent the thrombus or calcification fragments from rushing to the telecentric end along with blood flow to cause vascular embolism, and therefore the risks of local pain, tissue necrosis, hemiplegia, dementia and even death of a patient are avoided.

This invention discloses the application of DNA methyl donors in the preparation of drugs for treating severe acute pancreatitis and / or its complications, as well as a method for screening candidate drugs. The application of DNA methyl donors provided by this invention in the preparation of drugs for treating severe acute pancreatitis and / or its complications, by supplementing the methyl donor, restores the methylation level of the Foxp1 enhancer, blocks the "FOXP1-CXCR4" axis upstream, significantly reduces pancreatic microthrombus formation and alleviates tissue necrosis, and avoids the systemic side effects of directly antagonizing CXCR4.

The invention discloses a microwave ablation tissue monitoring system and method based on acoustic resonance frequency shift, and relates to the field of medical science and technology, and the key point of the technical scheme is that the microwave ablation tissue monitoring system comprises a microwave ablation probe, an acoustic sensing module, a signal processing unit and an ablation control terminal. A piezoelectric excitation array and an acoustic receiving array are integrated, a coded sound wave pulse is transmitted to a target tissue, an echo signal is received, and tissue resonance frequency offset f is extracted from the echo signal so as to judge the conformation state of collagen in the tissue. The system may dynamically adjust a microwave energy parameter or terminate ablation based on the state. The system can realize real-time identification and feedback control of a tissue necrosis state, has higher sensitivity, molecular-level identification capability and closed-loop regulation and control advantages compared with a traditional electrical or thermal monitoring mode, and effectively improves the precision and safety of microwave ablation treatment.

The invention relates to a blood vessel anastomosis device capable of adjusting anastomosis spacing, which comprises two anastomosis rings, limiting holes matched with each other are formed in the two anastomosis rings, an anastomosis needle and an anastomosis hole are arranged on one end face of each anastomosis ring, and the anastomosis needle and the anastomosis hole on one anastomosis ring are matched with the anastomosis hole and the anastomosis needle on the other anastomosis ring respectively; and the driving module is matched with the first anastomosis ring and / or the second anastomosis ring so as to drive the first anastomosis ring and the second anastomosis ring to move relatively. The anastomosis needles and the anastomosis holes of the two anastomosis rings are matched, so that the accuracy of vascular anastomosis on the anastomosis rings is ensured. The anastomosis rings are driven by the driving module, so that the relative positions of the two anastomosis rings can be adjusted, the pressure applied to the blood vessel by the two anastomosis rings can be adjusted conveniently, blood leakage of the blood vessel due to insufficient pressure is avoided, and tissue necrosis caused by overlarge pressure is avoided.