The invention provides an HIFU (high-intensity focused ultrasound) treatment curative effect monitoring and ultrasound dosage control system and an HIFU treatment curative effect monitoring and ultrasound dosage control method. Aiming at the problems that in the traditional HIFU treatment, the temperature and curative effect monitoring sensitivity is low, the precision is poor, and the spatial resolution is low, the following scheme is adopted: the tissue impedance mutation reaching the tissue thermal injury critical temperature, namely, 70 DEG C within the HIFU focal region radial direction +/-0.4mm is taken as the real-time monitoring parameter for evaluating the HIFU treatment curative effects, and the ultrasound action time is combined for controlling the ultrasound dosage, based on the relation between the RIV (relative impedance variation) and the acoustic power, the relative variation of the tissue body surface impedance is adopted for quantitatively evaluating the HIFU treatment curative effects, the HIFU ultrasound power also can be adopted for regulating the treatment time, thus the accurate control over the ultrasound dosage is realized, therefore, a novel noninvasive real-time curative effect monitoring and ultrasound dosage controlling technology is provided for the HIFU treatment, the accurate control over the ultrasound dosage for regulating the treatment time according to the HIFU acoustic power is realized, good sensibility and high resolution ratio are realized, the application demand for the HIFU treatment is satisfied, and the system and the method can be widely applied to the fields including biomedical engineering, tumor diagnosis and treatment, and the like, and have great guiding significance and broad application prospect for the HIFU treatment.