61 results about "Hifu treatment" patented technology

A medical procedure utilizes a high-intensity focused ultrasound instrument having an applicator surface, a liquid-containing bolus or expandable chamber acting as a heat sink, and a source of ultrasonic vibrations, the applicator surface being a surface of a flexible wall of the bolus, the source of ultrasonic vibrations being in operative contact with the bolus. The applicator surface is placed in contact with an organ surface of a patient, the source is energized to produce ultrasonic vibrations focused at a predetermined focal region inside the organ, and a temperature of liquid in the bolus is controlled while the applicator surface is in contact with the organ surface to control temperature elevation in tissues of the organ between the focal region and the organ surface to necrose the tissues to within a desired distance from the organ surface.

A HIFU compatible receiving coil for MRI radio-frequency signals has an antenna and an amplifier connected to each other, each for receiving and amplifying MRI radio-frequency signals, and a filter positioned in front of the amplifier for filtering the HIFU low frequency signals received by the antenna at the same time as receiving the MRI radio-frequency signals. In a method for receiving the MRI radio-frequency signals and then for amplifying the same, the received MRI radio-frequency signals are filtered before being amplified, so as to filter out the HIFU signals received at the same time as the MRI radio-frequency signals. By this filtering, the HIFU signals among the HIFU signals and MRI radio-frequency signals simultaneously received by the antenna are filtered out at the same time as the HIFU treatment, and the remaining MRI radio-frequency signals are connected into the MRI system after being amplified by the amplifier for real-time imaging. Since the amplifier only processes the MRI radio-frequency signals, it can stay in a normal linear working status to ensure the normal proceeding of the subsequent real-time imaging.

A treatment device and methods for HIFU treatment of thyroid and parathyroid disorders are provided. The treatment method comprises identifying a treatment zone and directing high intensity focused ultrasound energy towards the treatment zone. The treatment device comprises the first sensor for detecting swallowing motion and the second sensor for tracking the motion of the thyroid and parathyroid tissue with ultrasound imaging. Thus, the treatment device allows for safe and non-invasive use of HIFU on thyroid and parathyroid tissue of patients by synchronizing HIFU pulse delivery with patient swallowing and / or directing the applicator of HIFU energy to follow the appropriate tissue when the patient moves.

In a medical device with at least one transducer fashioned for generation of high-intensity focused ultrasound and with a magnetic resonance apparatus as well as associated ultrasound transducer, and method for generation of magnetic resonance exposures, at least one shim element is associated with the transducer for compensation of a susceptibility difference caused by the design of the transducer with regard to the transducer environment.

The present invention discloses a particle enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprised of a core material encapsulated by a membrane-forming material and a continuous phase comprising of aqueous medium. The discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-8 μm; the amount of the membrane-forming material in the enhancement agent is 0.1-100 g / L; the core material is comprised of a liquid that does not undergo a liquid-gas phase transition at 38-100° C., and the amount of core material in the enhancement agent is 5-200 g / L.

The invention discloses a method for reducing the temperature error in magnetic resonance temperature imaging, which is used for the high-intensity focused ultrasound HIFU treatment monitored by magnetic resonance, the method comprises that: a reference image which is generated on two or more positions by an HIFU treatment head is carried out the interpolation, thus obtaining the reference image of the moving position of the HIFU treatment head; and the temperature change of a heating region is calculated according to a phase diagram of the interpolated reference image of the moving position of the HIFU treatment head and a heating image which is generated at the position by the HIFU treatment head. The invention further discloses a device for reducing the temperature error in the magnetic resonance temperature imaging, which comprises a reference image interpolation unit and a temperature calculation unit. The usage of the method and the device of the invention can significantly reduce the temperature error which is caused by the change of the magnetic susceptibility during the movement of the HIFU treatment head, which can not only obtain the accurate temperature change of the heating region, but also can reduce the complexity of the operation and the treatment time of the HIFU treatment.

The invention discloses a B ultrasonic image-based space-time quantization monitoring system and a method for realizing ultrasonic cavitation during HIFU (High Intensity Focused Ultrasound) treatment, belonging to the technical field of HIFU sound field measurement. The method comprises the steps of: 1, capturing in-vitro phantom video images; 2, intercepting the region of a cavitation bubble cluster; 3, removing the interference of B ultrasonic image interference fringes; 4, obtaining the region profile of an image cavitation bubble cluster and counting the pixel dots in the region profile; 5, carrying out the operation of step four on each frame of image to obtain the change rule of the area of the cavitation bubble cluster along with the time. The system comprises a B ultrasonic image capturing system, a signal generator, a power amplifier, an impedance matching circuit, a phantom, an ultrasonic probe, a three-dimensional motion platform and a focusing energy converter, and is simple in structure and convenient to control. According to the B ultrasonic image-based space-time quantization monitoring system and method for realizing ultrasonic cavitation during HIFU treatment, the interference fringes caused by the inconsistence of the B ultrasonic scanning frequency and the HIFU pulse frequency is removed, so that the accurate quantization of the area of the cavitation bubble cluster is realized and the system dispenses with the enhancement of the complexity and the sacrifice of the compatibility.

A high-intensity focused ultrasound device with a translatory dive assembly and a rotary drive assembly mounted to a single-piece frame and disposed therewith inside a handle casing includes a focused ultrasound transducer driven by the drive assemblies via a pair of transducer shafts surrounded by an inner sleeve and outer sleeve that sandwich a bolus tube, the outer sleeve being slidably removable from atop the inner sleeve.

The present invention discloses a plasmid enhancement agent for high intensity focused ultrasound (HIFU) treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a nanometer-sized biocompatible solid. The present invention also discloses another plasmid enhancement agent for HIFU treatment, wherein, the enhancement agent comprises a discontinuous phase is comprised of a core material encapsulated by a membrane-forming material, and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and has a particle size ranging from 10-1000 nm; the amount of the membrane-forming material in the enhancement agent is 0.1-100g / L; and the core material comprises nanometer-sized biocompatible solid selected from the group consisting of magnetic biomaterials, hydroxylapatite, and calcium carbonate, and the amount of the core material in the enhancement agent is 0.1-150 g / L.

The present invention discloses a fluorocarbon emulsion enhancement agent for HIFU treatment, which can increase acoustic energy deposition at the target location during HIFU treatment. The enhancement agent comprises a discontinuous phase comprising of a core material encapsulated by a membrane-forming material and a continuous phase comprised of aqueous medium; the discontinuous phase is uniformly dispersed in the continuous phase and the particle size of the discontinuous phase ranges from 0.1-2 μm; the amount of the membrane-forming material in the enhancement agent is 0.1-100 g / L; the core material is comprised of a liquid that undergoes a liquid-gas phase transition at 38-100° C., and the amount of the core material in the enhancement agent is 5-200 ml / L. The fluorocarbon emulsion enhancement agent for HIFU treatment of the present invention can significantly change the acoustic environment of the target location and can increase acoustic energy deposition at the target location during HIFU treatment.

The invention provides a B-mode ultrasound monitoring mechanism for high intensity focused ultrasound (HIFU) treatment. The B-mode ultrasound monitoring mechanism for HIFU treatment comprises a lifting motor module, a lifting mechanism guide module, a lifting cylinder and a B-mode ultrasound probe fixing module, wherein the lifting motor module comprises a lifting motor and a screw rod nut mechanism; the lifting mechanism guide module is connected with the screw rod nut mechanism; the lifting cylinder is matched with the lifting mechanism guide module to form a precision guide motion pair; andthe B-mode ultrasound probe fixing module is connected with the lifting mechanism guide module through pressure transmitters, and a B-mode ultrasound probe is arranged on the B-mode ultrasound probefixing module. According to the B-mode ultrasound monitoring mechanism for HIFU treatment, the pressure transmitters are arranged on the lifting mechanism guide module and the B-mode ultrasound probefixing module, a measurement signal is generated through pressure difference applied to both sides, so that the pressure transmitters only measure the pressure applied to a patient without measuring system friction force, the B-mode ultrasound probe can be driven to move precisely according to the treatment requirements, the focal area can be accurately located and monitored, and the accuracy of area setting and the quality of process monitoring are improved.

The invention discloses a method for preparing an AuNPs@PDA / PLGA nanocapsule and belongs to the field of ultrasonic medicine. According to the method, a PDA / PLGA nanocapsule is formed firstly through auto polymerization of dopamine in an alkalescence aqueous environment, then a chloroauric acid solution is added, and AuCl4-ions are adsorbed by PDA molecules onto the surface of the PDA / PLGA nanocapsule and reduced to nanogold particles to form the AuNPs@PDA / PLGA nanocapsule. The method is simple, mild and environment friendly, and extra toxicity is avoided. The diameter of the prepared nanocapsule is 1-3 mm, and the nanocapsule is hollow inside and is well compatible with gold nanoparticles. The nanocapsule not only has high external ultrasound contrast imaging capacity, but also can enhance the HIFU treatment effect when used in degassed bovine liver ex vivo.

The present invention provides a method for heating a target zone (3) of a subject of interest (1) according to pre-defined heating requirements using ultrasonic irradiation, comprising the steps of providing an ultrasonic irradiation device comprising a set of individually controllable transducer elements in vicinity of the target zone (3), defining at least one sensitive zone (2) within an area (4) covered by ultrasonic irradiation device, and controlling the ultrasonic irradiation device to apply sonications of ultrasonic energy to the target zone (3) to achieve the desired heating thereof, wherein the transducer elements are individually controlled in phase and amplitude to provide the sonications as a beam (5) directed towards the target zone (3), wherein the beam (5) has a energy distribution so that the pre-defined heating requirements of the target zone (3) are met and the exposure of the at least one sensitive zone (2) is minimized The present invention further provides an ultrasonic irradiation device adapted to perform the above method. By individually controlling the transducer elements, beam shaping of the ultrasonic irradiation can be applied over sensitive zones like scars, bones, bowels, spines or others without associating an intensity limit or energy exposure limit thereto. Such a configuration of active elements is sought, that the exposure on the sensitive zone is minimized, without compromising focal properties or violating restrictions on the number of active elements.

The invention discloses a fluorocarbon emulsion auxiliary agent for increasing targeted area tissue energy deposition in HIFU treatment, which includes non-continuous phase constituted by filming material coating and continuous phase constituted by water-based medium, the non-continuous phase is dispersed in the continuous phase homogeneously, grain size of the non-continuous phase is 0.1-2um, the content of the film-forming material in the auxiliary agent is 0.1-100g / L, the core material is a liquid for generating liquid / gaseous phase change at 38-100 deg C, the content in the auxiliary agent is -200mg / L. The invention also discloses the use of the fluorocarbon emulsion auxiliary agent in HIFU treatment.

The invention discloses a particle type auxiliary agent for increasing targeted area tissue energy deposition in HIFU treatment, which includes non-continuous phase constituted by filming material coating and continuous phase constituted by water-based medium, the non-continuous phase is dispersed in the continuous phase homogeneously, grain size of the non-continuous phase is 0.1-8um, the content of the film-forming material in the auxiliary agent is 0.1-100g / L, the core material employs liquid producing no liquid / gas phase change at 38-100 deg C, the content in the auxiliary agent is 5-200g / L. The invention also discloses the use of the particle auxiliary agent in HIFU treatment.

The invention relates to a multifunctional nano diagnosis system integrated with common support of hydrophilic and hydrophobic molecules, temperature response release, enhanced ultrasound imaging and high-intensity focused ultrasound (HIFU) treatment, and a preparation method thereof. The nano diagnosis system mainly comprises hollow mesoporous silica and menthol, and the hollow mesoporous silica and menthol are good in biosecurity, and have broad application prospects in inhibition of the tolerance in a multi-drug support manner, controllable local temperature response release, enhancement of the ultrasound imaging contrast as an ultrasonic contrast agent and an HIFU synergist and improvement of the HIFU treatment efficiency. The preparation method comprises the following steps: preparing hollow mesoporous silica balls of which the particle sizes are 600+ / -50nm and the shell layer thickness is 75+ / -5nm by a modified structure difference selection etching method; then carrying out menthol support or common support of a menthol and dye molecule mixture by taking the hollow mesoporous silica as a vector, so as to obtain the multifunctional nano diagnosis system. The preparation method disclosed by the invention is simple and feasible, free of pollution, high in yield, and good in flexibility.

The present invention relates to an ultrasound probe head (1), especially for HIFU treatment, comprising a treatment ultrasound transducer (2) and an imaging ultrasound transducer (3). The imaging transducer (3) comprises a shield element (4) configured such that most of the energy of ultrasound waves (10) reflected in the direction of the imaging transducer (3) are held back by said shield element (4). The shield element (4) is configured in such a way as not to interfere with the emission of the imaging ultrasound waves (7).

The invention relates to a three-dimensional body treatment device having a function of ultrasonic spherical surface scanning. The three-dimensional body treatment device comprises an ultrasonic focused transducer, wherein a position finding probe lifting device and a position finding probe rotating device are mounted at a center hole of the ultrasonic focused transducer. The three-dimensional body treatment device is characterized in that a swinging mechanism, a rotating mechanism and a lifting mechanism are sequentially in series connection to the upper end of the ultrasonic focused transducer; the lower end of the swinging mechanism is hinged to the ultrasonic focused transducer through a swinging rotating shaft, and the upper end of the swinging mechanism is fixedly connected with a rotating disk of the rotating mechanism; the rotating mechanism is connected with the free end of the lifting mechanism; and an HIFU treatment head is formed by the ultrasonic focused transducer, the swinging mechanism, the rotating mechanism, the lifting mechanism, the position finding probe lifting device, the position finding probe rotating device and a water tank or a water sac for accommodatingcoupling water. According to the three-dimensional body treatment mechanical structure having the function of ultrasonic spherical surface scanning disclosed by the invention, the treatment head is small in diameter and light in weight; and during treatment, moving the three-dimensional body treatment mechanical structure is not needed, the defects of a conventional mechanical structure are overcome, and the treatment requirements of performing thermal ablation on a three-dimensional scanning body in an arbitrary shape in the treatment range are completed.

The invention provides a composite nano material with calcium peroxide coated with silicon dioxide. The composite nano material comprises a calcium peroxide nano material; the surface of the calcium peroxide nano material is coated with the silicon dioxide to form a SiO2-coated CaO2 composite nano material; then the surface of the SiO2-coated CaO2 composite nano material is modified with 3-aminopropyltriethoxysilane to obtain amino-modified SiO2-coated CaO2, i.e. the composite nano material with the calcium peroxide coated with the silicon dioxide. The invention further provides a preparationmethod of the composite nano material. The invention further provides application of the composite nano material in preparation of drugs for enhancing high-intensity focused ultrasound treatment of tumors. According to the composite nano material as well as the preparation method and application thereof, the SiO2-coated CaO2-NH2 nano material reaching a tumor region can be decomposed in a tumor environment to generate oxygen, so that the cavitation effect in the HIFU treatment process is enhanced, and the purpose of enhancing the HIFU treatment effect is achieved.

The present invention discloses an enhancement agent for high intensity focused ultrasound (HIFU) treatment, which is administered to a patient before HIFU treatment and can reduce the level of EEF at the target location to be treated with HIFU. EEF is presented by the expression: EEF=ηPt / V (unit: J / mm3), and refers to the HIFU energy needed to effectively treat a tumor per unit volume of the tumor, wherein, η=0.7; P refers to the total acoustic power of HIFU source (unit: W); t refers to the total time of HIFU treatment (unit: s); V refers to the volume of HIFU-induced lesions (unit: mm3). If the amount of EEF at the target location before administration of the enhancement agent is defined as EEF(base) and the amount of EEF at the target location after administration of the enhancement agent is defined as EEF(measurement), the ratio between EEF(base) and EEF(measurement) is more than 1, preferably more than 2, and more preferably over 4. The use of the enhancement agent for HIFU treatment of the present invention makes it possible to treat deep-seated tumors. In addition, patients with hepatic tumors can be effectively treated without removal of ribs. Accordingly, the present invention discloses methods for increasing acoustic energy deposition at target location during HIFU treatment and screening the enhancement agents for HIFU treatment.

Provided is a special-purpose coil guided by MRI and used for HIFU treatment of animal tumours. The coil comprises a support table, an arc support erected on the bottom surface of the support table, an operation panel and a through hole. The arc space is formed by the arc support and the upper bottom surface of the support table. The lower bottom surface of the support table and the outer surface of the arc support are uniformly attached with multi-channel coils used for collecting MRI images. The operation panel is slidably arranged on the upper bottom surface of the operation table and penetrates through the arc space. The operation panel is provided with an animal clamp, an anaesthetic mask and an anaesthetic pipeline, all of which are arranged in the arc space. The through hole penetrates through upper and lower bottom surfaces of the support table and the operation panel to the arc space. Therefore, a focused ultrasound channel is formed. The multi-channel design is adopted so that the coil is excellent in performance. The images can be collected at a faster pace and the coil has good real-time monitoring performance. The animal fixing clamp and a gaseous anesthesia pipeline are designed so that animals can be narcotized for a longer time. The fixation postures are comfortable and stable and convenient to move. Operation is carried out easily and conveniently.

The invention provides an HIFU (high-intensity focused ultrasound) treatment curative effect monitoring and ultrasound dosage control system and an HIFU treatment curative effect monitoring and ultrasound dosage control method. Aiming at the problems that in the traditional HIFU treatment, the temperature and curative effect monitoring sensitivity is low, the precision is poor, and the spatial resolution is low, the following scheme is adopted: the tissue impedance mutation reaching the tissue thermal injury critical temperature, namely, 70 DEG C within the HIFU focal region radial direction + / -0.4mm is taken as the real-time monitoring parameter for evaluating the HIFU treatment curative effects, and the ultrasound action time is combined for controlling the ultrasound dosage, based on the relation between the RIV (relative impedance variation) and the acoustic power, the relative variation of the tissue body surface impedance is adopted for quantitatively evaluating the HIFU treatment curative effects, the HIFU ultrasound power also can be adopted for regulating the treatment time, thus the accurate control over the ultrasound dosage is realized, therefore, a novel noninvasive real-time curative effect monitoring and ultrasound dosage controlling technology is provided for the HIFU treatment, the accurate control over the ultrasound dosage for regulating the treatment time according to the HIFU acoustic power is realized, good sensibility and high resolution ratio are realized, the application demand for the HIFU treatment is satisfied, and the system and the method can be widely applied to the fields including biomedical engineering, tumor diagnosis and treatment, and the like, and have great guiding significance and broad application prospect for the HIFU treatment.

A treatment device and methods for HIFU treatment of thyroid and parathyroid disorders are provided. The treatment device comprises the first sensor for detecting swallowing motion and the second sensor for tracking the motion of the thyroid and parathyroid tissue with ultrasound imaging. Thus, the treatment device allows for safe and non-invasive use of HIFU on thyroid and parathyroid tissue of patients by synchronizing HIFU pulse delivery with patient swallowing and / or directing the applicator of HIFU energy to follow the appropriate tissue when the patient moves.

According to the efficient and accurate division method for the ultrasonic positioning fibromyoma image, a computer-aided ultrasonic image division method is adopted for overcoming the defects that inthe prior art, division of an ultrasonic positioning navigation image is mostly completed manually, and is tedious and time-consuming. According to the ultrasonic image division method based on segmentation and merging, pixel points are not directly clustered, but superpixels are clustered, so that the calculation amount is greatly reduced, and the efficiency of the whole ultrasonic image division method is improved. Characteristic extraction is performed on superpixels rather than pixel points, so that the obtained texture characteristics are more robust, and the method adapts to the characteristics of poor HIFU ultrasonic positioning navigation image quality. According to the image division method, various situations of the ultrasonic image can be processed, and a good division effect on the ultrasonic image with an extremely low signal-to-noise ratio is achieved. The method is accurate in division result and low in manual intervention degree, and can be efficiently applied to actual ultrasonic positioning navigation for HIFU treatment of fibromyoma.

The invention provides an online detection method for a focused ultrasonic field. The method comprises that ultrasonic signals are emitted and received, corresponding time delay and signal amplitude change are obtained, the sound speed and sound attenuation are calculated, a sound speed and attenuation characteristic distribution function of a biologic tissue in a treatment area can be obtained accurately in real time, and a sound field is reconstructed via a biologic layered medium model and an SBE equation. Thus, the focusing position and the sound intensity of a focus can be controlled accurately, and it is fully ensured that HIFU treatment is safe and effective.

The invention belongs to the medical technology field, in particular relating to a method for enhancing high intensity focused ultrasound (HIFU) induced anti-tumor immune response. On the premise of having no change on the existing HIFU oncotherapy ultrasound strength, the method utilizes a sparse scanning strategy to enable tumor tissue heat denaturation spots generated by single HIFU treatment to have a proper spacing so as to reserve tissues around each heat denaturation area. The method can enable the tumor issues to have stronger capacity of recruiting and activating interdigitate cells and inducing out stronger anti-tumor immune response while having no influence on primary tumor thermal ablation curative effect by HIFU, thus killing epibiotic viable cells and preventing and curing tumour distant metastases. The method can improve overall tumor curative effect of HIFU and shorten curative time.

A HIFU compatible receiving coil for MRI radio-frequency signals has an antenna and an amplifier connected to each other, each for receiving and amplifying MRI radio-frequency signals, and a filter positioned in front of the amplifier for filtering the HIFU low frequency signals received by the antenna at the same time as receiving the MRI radio-frequency signals. In a method for receiving the MRI radio-frequency signals and then for amplifying the same, the received MRI radio-frequency signals are filtered before being amplified, so as to filter out the HIFU signals received at the same time as the MRI radio-frequency signals. By this filtering, the HIFU signals among the HIFU signals and MRI radio-frequency signals simultaneously received by the antenna are filtered out at the same time as the HIFU treatment, and the remaining MRI radio-frequency signals are connected into the MRI system after being amplified by the amplifier for real-time imaging. Since the amplifier only processes the MRI radio-frequency signals, it can stay in a normal linear working status to ensure the normal proceeding of the subsequent real-time imaging.

The invention discloses a risk assessment method for HIFU treatment equipment based on inverse heat conduction, comprising the following steps: (1) measuring the temperature change of a simulated human body soft tissue, and presetting the position of a focal region; (2) determining the accurate position of an ultrasound beam through inverse conduction optimization; (3) determining the temperature distribution inside and outside the focal region: determining the temperature change of the simulated human body soft tissue according to the actual focusing position (xf, yf, zf) of the ultrasound beam, and further, determining the temperature distribution inside and outside the focal region and getting the ultrasonic power distribution within the tissue; and (4) getting a risk assessment conclusion: comparing the value of temperature distribution inside and outside the focal region with a standard value or a safety value, judging that the equipment can continue being used in clinic if the value of temperature distribution inside and outside the focal region accords with the standard value or is within the scope of the safety value, or judging that the equipment needs maintenance. The ultrasonic beam is prevented from being directly irradiated on a thermocouple, the influence of heating of the thermocouple on tissue temperature measurement is mitigated, the precision of temperature measurement is improved, and the cost of risk assessment is lowered.

The invention relates to a focused ultrasound device with two-dimensional imaging and HIFU treatment for small animals, comprising a platform, wherein the platform is connected with a pillar, the pillar is installed with a moving mechanism, and the moving mechanism is connected with a focusing transducer; The motion mechanism and the focusing transducer are electrically connected to the control host. As that small animal has the characteristic of small volume and shallow treatment depth, the invention adopts the design of a focused ultrasonic transducer with high working frequency, short focallength and fixed focus to realize miniaturization of the focused transducer and miniaturization of a focused ultrasonic device integrating two-dimensional imaging and treatment. The movement mechanism of the invention realizes the movement of the coronal plane of the small animal; focusing transducers enable imaging and treatment of the focal zone; a control panel enables 2D imaging and planned treatment; the invention realizes the visualization of coronal HIFU treatment in small animals, in order to reduce the manipulation time and improve the safety and effectiveness of HIFU treatment in small animals.