HIFU (high-intensity focused ultrasound) treatment curative effect monitoring and ultrasound dosage control system and method
A focused ultrasound and dose control technology, used in ultrasonic therapy, treatment and other directions, can solve the problems of low spatial resolution, low measurement sensitivity, slow speed, etc., and achieve the effect of meeting application requirements, high resolution, and accurate control.
Active Publication Date: 2017-05-31
NANJING NORMAL UNIVERSITY
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[0004] Purpose of the invention: The purpose of the present invention is to provide a high-intensity focused ultrasound treatment efficacy monitoring and ultrasound dose control for the...
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[0024] Embodiment: A high-intensity focused ultrasound therapy curative effect monitoring and ultrasound dose control system and method, the specific operations are as follows:
[0025] The tissue used in the experiment of this example was prepared by the sol-gel method model, and 10g of acrylamide, 0.05g of ammonium persulfate, 0.3g of methylenebisacrylamide, and 35mL of egg white were added to 0.9% normal saline to configure 100mL of gel sol, then add 0.2mL of tetramethylethylenediamine and stir well, pour it into a custom-made cylindrical acrylic mold with a diameter and height of 3.2cm and 3.5cm, respectively, for shaping. The egg white is used as a temperature indicator. When the temperature reaches 70°C, the protein will be denatured, changing from transparent light yellow to opaque white.
[0026] Such as figure 1 As shown in the figure, the HIFU treatment system is established. The computer A is connected to the signal generator B, and the control signal source output...
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Abstract
The invention provides an HIFU (high-intensity focused ultrasound) treatment curative effect monitoring and ultrasound dosage control system and an HIFU treatment curative effect monitoring and ultrasound dosage control method. Aiming at the problems that in the traditional HIFU treatment, the temperature and curative effect monitoring sensitivity is low, the precision is poor, and the spatial resolution is low, the following scheme is adopted: the tissue impedance mutation reaching the tissue thermal injury critical temperature, namely, 70 DEG C within the HIFU focal region radial direction +/-0.4mm is taken as the real-time monitoring parameter for evaluating the HIFU treatment curative effects, and the ultrasound action time is combined for controlling the ultrasound dosage, based on the relation between the RIV (relative impedance variation) and the acoustic power, the relative variation of the tissue body surface impedance is adopted for quantitatively evaluating the HIFU treatment curative effects, the HIFU ultrasound power also can be adopted for regulating the treatment time, thus the accurate control over the ultrasound dosage is realized, therefore, a novel noninvasive real-time curative effect monitoring and ultrasound dosage controlling technology is provided for the HIFU treatment, the accurate control over the ultrasound dosage for regulating the treatment time according to the HIFU acoustic power is realized, good sensibility and high resolution ratio are realized, the application demand for the HIFU treatment is satisfied, and the system and the method can be widely applied to the fields including biomedical engineering, tumor diagnosis and treatment, and the like, and have great guiding significance and broad application prospect for the HIFU treatment.
Description
technical field [0001] The invention relates to the technical field of high-intensity focused ultrasound, in particular to a system and method for monitoring therapeutic effect of ultrasound treatment and controlling ultrasound dose. Background technique [0002] High Intensity Focused Ultrasound (HIFU) treatment of tumors has the advantages of non-intervention, less trauma, faster recovery, and less likely to cause cancer cell metastasis. HIFU efficacy and transducer focal area, ultrasound intensity, treatment time and tissue differences related. In order to ensure the reliability and safety of HIFU treatment, temperature control is the key to killing tumor cells without damaging normal tissues. Therefore, real-time temperature monitoring and curative effect evaluation during HIFU treatment are of great importance to the clinical application of tumor treatment. significance. In HIFU treatment, it is necessary to rapidly increase the temperature of the focal tissue to 70°C...
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Login to view more IPC IPC(8): A61N7/02
CPCA61N7/02
Inventor 马青玉郭各朴宿慧丹
Owner NANJING NORMAL UNIVERSITY
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