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Nerve conduit material having topological structure and modified by CNT/conducting polymer composite coating and preparation method of nerve conduit material

A technology of conductive polymers and nerve guides, applied in coatings, medical science, prostheses, etc., can solve problems such as poor functional recovery, poor conductivity, and non-conductivity

Inactive Publication Date: 2014-09-24
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional scaffold materials for nerve repair are non-conductive or poorly conductive, and cannot implement electrical signal transmission during nerve repair to stimulate and guide nerve growth and axon regeneration
Although there are a large number of regenerated nerve fibers after nerve repair, the functional recovery is poor due to the atrophy of target organs such as the motor end plate due to the loss of electrical stimulation

Method used

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  • Nerve conduit material having topological structure and modified by CNT/conducting polymer composite coating and preparation method of nerve conduit material
  • Nerve conduit material having topological structure and modified by CNT/conducting polymer composite coating and preparation method of nerve conduit material
  • Nerve conduit material having topological structure and modified by CNT/conducting polymer composite coating and preparation method of nerve conduit material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Oriented polylactic acid (PLLA) fibers are achieved by electrospinning technology. 0.36g of PLLA was dissolved in 2.65g of a mixture of chloroform and ethanol (volume ratio: 3:1), and stirred for 0.5h to obtain a uniform PLLA solution for spinning. The electrospinning voltage was set at 6.5kV, and the distance from the receiver to the needle tube was 7.5cm, so that the fiber diameter was between 1-2μm, and then the PLLA spinning fibers were collected on the catheter substrate through static parallel electrodes, and placed Bake in an oven at 60°C for 0.5h, take it out and set aside.

[0032] Measure 75 μL of 0.1M Al(NO 3 ) 3 / ethanol solution was added to a glass bottle containing 19.5mL of absolute ethanol, and then 0.5mL of mixed acid-treated single-walled CNT / ethanol dispersion (dispersion concentration: 0.5mg / mL) was added to the glass bottle, under the condition of 40kHz After ultrasonication for 5min, it was used for electrophoretic deposition. In this embodime...

Embodiment 2

[0038] A CNT-coated modified catheter material with an oriented groove structure was prepared in the same manner as in Example 1. The electrospinning voltage was set at 8 kV, and the electrophoretic deposition time was set at 10 min. The modified catheter prepared above was used as a working electrode, and in a mixed aqueous solution of 0.1M sodium p-toluenesulfonate and 0.01M 3,4-ethylenedioxythiophene, electrochemical pulse polymerization was used to deposit a conductive electrode on the surface of the CNT bundle. polymer. Electrochemical deposition was carried out in an electrochemical workstation, using a three-electrode system, Ag / Ag + The electrode served as a reference electrode, and the Pt sheet served as a counter electrode. Polymerization potential 1.0V, deposition time (T d ) is 5s, sleep time (T r ) for 600s, repeated 12 cycles during the polymerization deposition process, and obtained a CNT / conductive polymer composite coating with a directional groove structur...

Embodiment 3

[0043] A CNT-coated modified catheter material with an oriented groove structure was prepared in the same manner as in Example 1. The electrospinning voltage was set at 8 kV, and the electrophoretic deposition time was set at 10 min. The modified electrode prepared above was used as a working electrode, and a conductive polymer was deposited on the surface of the CNT bundle by electrochemical pulse polymerization in a mixed aqueous solution of 0.1M lithium perchlorate and 0.02M aniline. Electrochemical deposition was carried out in an electrochemical workstation, using a three-electrode system, Ag / Ag + The electrode served as a reference electrode, and the Pt sheet served as a counter electrode. Polymerization potential 1.0V, deposition time (T d ) is 5s, sleep time (T r ) for 600s, repeated 4 cycles during the polymerization deposition process, and obtained the CNT / conductive polymer composite coating modified nerve conduit material with directional groove structure, which ...

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Abstract

The invention provides a nerve conduit material having a topological structure and modified by a CNT (Carbon Nano Tube) / conducting polymer composite coating and a preparation method of the nerve conduit material. With electro-spun polymer fibers as templates, CNTs are deposited on the surface of a substrate by use of an electrophoresis method so as to form a three-dimensional porous network CNT coating, next, solvent cleaning and ultrasonic stripping are carried out to form the CNT coating with a directional groove structure, then a conducting polymer is deposited by use of electro-chemical impulse polymerization, and the conducting polymer is coaxially wound around the surface of the CNT bundle to form the nerve conduit material modified by the CNT / conducting polymer composite coating having the directional groove structure. The surface of the nerve conduit material has two layers in the topological structure: at micrometer scale, the coating is provided with a patterned micrometer-scale groove for guiding the rearrangement of a neural cytoskeleton; at nanometer scale, the coating is provided with a nanometer-scale porous network structure for guaranteeing the physical conditions for the attachment and growth of nerve cells and excellent electrochemical properties of the nerve conduit.

Description

technical field [0001] The invention belongs to the technical field of neuroscience, and relates to a patterned design of a nerve guide material surface modification coating and a preparation method thereof, in particular to a nerve guide material modified by a CNT / conductive polymer composite coating with a topological structure and its According to the preparation method, the modified coating has good electrochemical performance and excellent cell compatibility, and can promote the attachment, migration, orientation, and growth of nerve cells on the surface of the catheter, thereby realizing the repair of nerve tissue damage. Background technique [0002] The treatment and repair of nerve tissue injury has always been an important research topic in the field of life sciences. Due to severe trauma, tumor resection, congenital deformity and other reasons, the repair and functional reconstruction of nerve defects are still clinical problems. For long-segment nerve defects, it...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/34A61L27/30
Inventor 肖迎红车剑飞肖横洋邢季
Owner NANJING NORMAL UNIVERSITY
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