825 results about "Nerve cells" patented technology

The present invention relates to a magnetism generation coil that provides non-invasive treatment by applying a magnetic field to nerve cells or muscle cells of the body. The magnetism generation coil of the present invention comprises: a coil bundle consisting of a collection of a plurality of unit coil strands of a copper material; and a hollow tube surrounding the coil bundle and formed of a flexible material. The unit coil strands forming the magnetism generation coil of the present invention may be formed of an oxygen-free copper (OFC) coil having a low ratio of oxygen to copper.

The present invention relates to a helmet-type magnetic stimulation device comprising an inner sheath in contact with a skull part when the device is worn. The helmet-type magnetic stimulation device of the present invention is a helmet-type magnetic stimulation device for applying a magnetic field to nerve cells in the skull part or scalp cells so as to provide a non-invasive treatment, and includes a dome part providing a space in which the skull part is accommodated when the helmet-type stimulation device is worn; and an inner sheath inserted into the dome part to adjust the inner diameter of the dome part, wherein the inner sheath includes: a circumferential part disposed in an area which annularly surrounds the skull part in order to adjust the inner diameter of the dome part; and a connection part connected to one end and the other end of the circumferential part so as to connect the one end and the other end while crossing the upper side of an opening formed by the circumferential part.

The invention provides a composition beneficial to improvement of brain cognition, memory and sleep and prevention and improvement of Alzheimer's disease, and belongs to the technical field of health food. The composition comprises L-alpha-glycerophosphorylcholine (GPC), phosphatidylserine (PS), docosahexaenoic acid (DHA), tea leaf theanine (L-theanine), vitamin B groups, vitamin D3 and the like, and is prepared into a health care product, a dietary supplement, a functional food, a medical food or a nutritional supplement by adopting the existing technology. The traditional Chinese medicine composition has the effects of effectively nourishing nerve cells, improving the brain sensitivity and improving the cognitive function. The composition is particularly directed at age-related cognitive decline and neurodegenerative diseases. Repair and regeneration of nerve cells can be promoted, the transmission efficiency of neural signals is enhanced, and the overall working efficiency of the brain is improved. Daily life challenges caused by cognitive decline can be relieved, and individual life quality can be improved.

The invention relates to Pediococcus pentosaceus PP90 for preventing and treating alcoholic nerve injury and application of the Pediococcus pentosaceus PP90, the Pediococcus pentosaceus PP90 is preserved in China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.32034. The Pediococcus pentosaceus PP90 can be used for preventing and treating alcoholic nerve injury. The fermentation product of the pediococcus pentosaceus PP90 can degrade the alcoholic strength of alcohol, can generate ethanol dehydrogenase and acetaldehyde dehydrogenase, can improve the activity of nerve cells, can regulate the expression of cytokines, can inhibit the activation of astrocytes, can regulate the expression of brain-derived neurotrophic factors, and can inhibit the growth of the brain-derived neurotrophic factors. The compound can improve the disordered neurotransmitter level, and can be used for preparing products for preventing or improving alcoholic nerve injury.

The invention discloses a neurology rehabilitation degree evaluation method and system, and relates to the technical field of medical rehabilitation evaluation.The method comprises the following specific steps that data collection is conducted, specifically, whole genome sequencing is conducted on a neurology patient, and whole genome data of the patient is obtained, the method comprises the following steps: collecting initial disease severity degree data of a patient, and evaluating the symptom expression of the patient when the patient sees a doctor for the first time by a professional neurology doctor according to a set disease evaluation standard. A key gene screening strategy and a synaptic plasticity index establishment method are applied to construct a multi-dimensional and more accurate neurology rehabilitation degree evaluation system, so that the neural function repair level is deeply known from the root level of nerve cell connection reconstruction; and accurate prediction and real-time evaluation of the rehabilitation process are realized through the personalized rehabilitation trajectory prediction model, so that the real rehabilitation state of the patient can be reflected more comprehensively and meticulously.

The invention relates to a pathologically responsive nano-carrier as well as a preparation method and application thereof, belongs to the technical field of biological medicines, and aims to solve the problems that in the prior art, nano-particles are enriched in livers and kidneys in quantity, the risk of damaging organs and tissues exists, toxic and side effects on patients with spinal cord injury are large, the treatment effect is not obvious and the like. The carrier is a self-assembled nanoparticle which takes PLGA as a skeleton structure, is externally modified with hyaluronic acid and is connected with RVG29 through a diselenide bond. The carrier can load an active substance, such as curcumin, can be used for treating spinal cord injury, and can target spinal cord tissues through intravenous administration, penetrate a blood spinal cord barrier, target CD44 through HA at the early stage of injury, increase immune cell uptake and inhibit inflammatory infiltration and inflammatory cascade. In the late stage of injury, the nerve cell uptake is increased through RVG29 targeted acetylcholine receptor (nAchR), and nerve repair and regeneration are promoted.

The invention provides a neuromuscular multi-element coupled organoid micro-fluidic chip, a device and a method. Relates to the technical field of organoid micro-fluidic chips. A first culture chamber, a second culture chamber and a third culture chamber are arranged in a culture layer of the chip; the first culture room is used for culturing nerve cells; the second culture room is used for culturing muscle cells; a microfluidic channel for communicating the first culture chamber with the second culture chamber is arranged between the first culture chamber and the second culture chamber; the third culture room is arranged on the micro-fluidic channel and is used for culturing a neuromuscular joint formed by convergence of axons of nerve cells and muscle cells; a microelectrode array plate is arranged in the circuit layer and is used for performing electrical stimulation and electrophysiological function detection on neuromuscular cells. Through the chip, co-culture of in-vitro nerves and muscle organs can be realized, a complex interaction relationship in a neuromuscular system can be accurately simulated, and the chip can also be used for constructing various neuromuscular related disease models.

The invention discloses application of a small molecule compound in preparation of a product for treating nervous system diseases. According to the application disclosed by the invention, it is determined for the first time that Chebulinic acid and 1, 1, 1-Kestohexenose are targeted PU.1 inhibitors, nerve cell activity decline caused by A beta deposition can be improved, and a new technical choice is provided for developing a treatment method for nerve injury diseases and protecting or improving nerve cell injury.

The invention relates to a method for mechanically regulating and controlling a nerve cell calcium ion signal by using an Airy beam to control an optical bullet, which comprises the following steps: firstly preparing the optical bullet and culturing HT-22 cells, then dynamically regulating and controlling the cell calcium ion signal, and finally monitoring and recording an image in the regulation and control process in real time through a CMOS (Complementary Metal Oxide Semiconductor) camera. According to the method, non-contact mechanical stimulation on nerve cells can be realized. The spatial resolution limitation of the traditional nerve regulation and control technology is broken through, and a non-invasive and high-biocompatibility nerve signal regulation and control means is provided. Besides, in combination with a real-time fluorescence monitoring technology, the regulation and control effect can be intuitively evaluated, and a brand new tool is provided for neuroscience research and clinical application.

The invention belongs to the field of health-care tea preparation, and particularly relates to begonia flower and leaf tea and a preparation method thereof. Triticale bran pulp is mixed with smashed begonia leaves, the mixture is fermented through a flavor improving fermentation inoculant and then mixed with an anti-oxidation and excitation-inhibiting solution, and the prepared low-caffeine tea base material does not cause insomnia, has the characteristics of inhibiting inflammation and resisting oxidation, protects nerve cells from being damaged, and is suitable for being used as a health-care tea base material. The honeysuckle, the endive and the soybeans are ground into thick liquid, then mixed with the repair juice, centrifuged to remove precipitates, and then frozen nano spray drying is carried out, so that the obtained nano particles for protecting the liver and the kidney and promoting circulation are higher in stability and can accelerate absorption of small intestines; a taste regulator obtained by mixing grain mucus with tartaric acid, ethyl maltol, methyl anthranilate and sorbic acid is sprayed on the surface of a begonia flower and leaf tea mixture, and the prepared begonia flower and leaf tea does not affect sleep after being drunk, does not damage livers and kidneys in organisms, is good in taste and is easy to drink for a long time.

The invention discloses a neural network selective forgetting learning method based on nerve cell importance, which comprises nerve cell importance evaluation, parameter mask generation, random label forgetting process and model fine tuning, and specifically comprises the following steps: distributing memory values of a forgetting sample by a model into nerve cells; the importance of the neurons on the forgotten data set is evaluated; setting the neuron mask with the memory value greater than a specific threshold value as 1, and otherwise, setting the mask as 0; randomly setting labels of samples in the forgotten data set, and updating neuron parameters of which the mask is 1 by using a stochastic gradient descent method; and finally, performing global fine adjustment on model parameters by using the reserved data set to obtain a final forgetting model. According to the image classification task-oriented neuron granularity selective forgetting learning method provided by the invention, the forgetting of feature levels is realized in the convolutional neural network, the forgetting effect and the original task performance are ensured, and meanwhile, the difference between approximate forgetting and accurate forgetting is reduced.

A preparation method for a bionic multi-channel nerve conduit, and a bionic multi-channel nerve conduit. A double-layer shape memory nanofiber membrane is used as a receiving substrate, strip-shaped and spaced gel strips are printed on an oriented side, seed cells are planted on the strip-spaced nanofiber membrane, temperature changes are adjusted to cause the fiber membrane at the bottom layer to have a deforming response and curl up, gel strips wrapped by the self-curling fiber membrane self-shape into a conduit, gaps between the gel strips form a multi-channel structure inside the conduit, an inner wall of the multi-channel nerve conduit becomes oriented natural polymer nanofibers which can provide directional guidance for nerve regeneration, and the multi-channel tube structure promotes the formation of a vascular network in the conduit and provides more space for nerve cell growth. The present invention can be applied to long-distance peripheral thick nerve defects, and has good application prospects.

The present invention relates to an optimized polynucleotide encoding a brain-derived neurotrophic factor (BDNF), a transgenic expression cassette comprising the polynucleotide, a recombinant vector, and a medicament useful for the prevention or treatment of neurodegenerative diseases, neurodevelopment-related diseases, stroke, chronic pain, nerve injury, mental disorders, and / or metabolic diseases. The polynucleotide disclosed by the invention can efficiently express the BDNF through codon optimization, and particularly, the expression quantity of the BDNF in nerve cells is remarkably improved.

The embodiment of the utility model discloses a three-dimensional array of integrated biological photoelectrodes, which comprises a plurality of electrode array layers, and the electrode array layers are laminated and connected along the longitudinal direction; and the electrode array layer is formed by arranging a plurality of integrated biological photoelectrodes in parallel. Integrated biological photoelectrodes with different lengths, LED wavelengths and other characteristics are arranged in multiple dimensions, each integrated biological photoelectrode can be provided with an independent bonding pad set, and during working, the device is inserted into biological brain tissue and immersed in a biological solution, so that the device is formed. And a photodiode is lightened, and a bioelectric signal is collected through a microelectrode array, so that the nerve cells are accurately controlled, and meanwhile, the collection range and the collection density of the nerve signals are effectively improved.

The invention provides cubilose peptide and a key preparation method of cubilose peptide maternity cubilose, and the preparation method of the cubilose peptide comprises the following steps: soaking dry cubilose in pure water at 0-4 DEG C according to a material-liquid ratio of 1: 10 for 2 hours, scattering, and spin-drying to obtain soaked cubilose; mixing the soaked cubilose with pure water according to a mass ratio of 1: (15-20), sealing, stewing at 121-123 DEG C for 12-15 minutes, cooling to room temperature, and repeatedly stewing once to obtain fresh stewed cubilose; carrying out an in-vitro digestion experiment on the freshly stewed cubilose, and simulating the digestion process of the freshly stewed cubilose in gastrointestinal tracts to obtain digested cubilose; and centrifuging the digested cubilose to obtain a supernatant, treating the supernatant, carrying out protein sequencing, and carrying out on-line database comparison to screen out peptide fragments with high matching degree and response value greater than 109, thereby obtaining the cubilose peptide. The cubilose peptide can significantly improve the proliferation rate of nerve cells, and provides a cell basis for the development of a nervous system.

The invention discloses a compound probiotic for improving cognitive function of old people and a preparation method and application thereof. Firstly, maltodextrin is dried and then sieved, metal impurities are removed after sieving, and maltodextrin freeze-dried powder, lactobacillus paracasei Lpc37 freeze-dried powder, phytobacterium plantarum Lp-115 freeze-dried powder and bifidobacterium animalis subsp. Lactis Bl-04 freeze-dried powder are weighed and sieved respectively; the preparation method comprises the following steps: preparing freeze-dried powder of three strains, then premixing the freeze-dried powder of the three strains with a part of maltodextrin, adding the residual maltodextrin after the strains are premixed, continuously mixing until the materials are uniformly distributed to obtain the compound probiotics, exerting a synergistic effect through a specific strain combination (Lp115 + Lpc37 + Bl-04), providing a new way for non-drug intervention, being beneficial to regulating intestinal flora metabolism (such as generating short-chain fatty acid SCFA), and improving the immunity of the human body. The synthesis and release of neurotrophic factors are promoted, the nerve cell function is improved, and the cognitive function improvement is indirectly assisted.

The invention belongs to the technical field of drug development, and particularly relates to application of 2-fluoro-N-(2-(4-methyl-2-(m-tolyl) thiazole-5-yl) ethyl) benzenesulfonamide in preparation of drugs for treating nervous system diseases. The invention aims to provide a medicine which has small toxic and side effects and can target SLC11A2 to treat or improve nerve cell injury. According to the technical scheme, the invention relates to application of 2-fluoro-N-(2-(4-methyl-2-(m-tolyl) thiazole-5-yl) ethyl) benzenesulfonamide in preparation of a medicine for treating nervous system diseases. It is proved that the compound 2-fluoro-N-(2-(4-methyl-2-(m-tolyl) thiazole-5-yl) ethyl) benzenesulfonamide is small in toxic and side effect, and nerve cell damage can be protected or improved by targeting SLC11A2; and a new choice is provided for treating or improving nerve cell injury.

The invention relates to the technical field of biological medicines, in particular to Hangzhou white chrysanthemum-derived exosome-like nano-vesicles as well as a preparation method and application thereof. Chrysanthemum morifolium ramat nano-vesicles are prepared from compositae plants through a high-speed centrifugation method, the average particle size of the nano-vesicles is 68 nm, and the Zeta potential is-19.50 + / -1.10 mV. The nano vesicles can effectively protect nerve cells and improve anxiety behaviors and cognitive impairment of SAE mice. The compound has a good application prospect in preparation of medicines for treating neuroinflammation and SAE.

The invention relates to the technical field of functional food, in particular to an eye-protecting and brain-strengthening composition as well as a preparation method and application thereof. The aronia, the astaxanthin, the DHA, the medlar, the hovenia dulcis thunb and the saffron crocus extract are compounded, various functional raw materials have a synergistic effect, the visual problem is improved through multiple channels, the cognitive ability is synchronously improved, and the astaxanthin eye drops have the effects of preventing retina oxidative damage, promoting eye blood circulation, relieving visual fatigue, protecting nerve cells and improving the cognitive state. Through reasonable proportioning, the composition for protecting eyes and strengthening brain has better effects of relieving visual discomfort, improving vision and improving brain health.

The invention belongs to the technical field of biological medicines, and particularly relates to a wheat peptide with antioxidant stress activity and a preparation method and application thereof. The invention provides a wheat peptide with antioxidant stress activity. The amino acid sequence of the wheat peptide is as shown in SEQ ID NO: 1. The invention discloses a wheat peptide FGWPGPK for protecting oxidative stress nerve cells as well as a screening method and application of the wheat peptide FGWPGPK. A target peptide fragment is identified from wheat germs through enzymolysis and multi-dimensional screening strategies, and it is proved that the target peptide fragment can significantly improve the survival rate of PC-12 cells damaged by H2O2 (72.88%) and reduce the ROS level (125.54%). The peptide fragment has strong antioxidant activity and nerve targeting property, and is suitable for preventing and treating neurodegenerative diseases such as Alzheimer's disease.

The invention relates to pediococcus acidilactici PA27 capable of degrading alcohol and improving alcoholic nerve injury and application of the pediococcus acidilactici PA27, the pediococcus acidilactici PA27 is preserved in China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.31922. The pediococcus acidilactici PA27 can degrade alcohol and improve alcoholic nerve injury. The pediococcus acidilactici PA27 separated and screened by the invention can grow and propagate in an alcohol-containing culture medium, can degrade alcohol and can generate ethanol dehydrogenase and acetaldehyde dehydrogenase; the polypeptide can be used for constructing a blood-brain barrier and reducing the damage of alcohol to central nervous cells; the traditional Chinese medicine composition can reduce the expression of inflammatory cytokines TNF-alpha, inhibit the activation of astrocytes, promote the expression of brain-derived neurotrophic factors BDNF, regulate the release of alcohol-induced astrocyte neurotransmitters and improve alcoholic nerve injury.

The invention relates to the technical field of photoelectric materials, in particular to application of a Van der Waals tellurium nano material as a near-infrared IIa light nerve regulation material. The invention provides an application of a Van der Waals Te nanometer material as a near-infrared IIa light nerve regulation material, and a preparation method of the Van der Waals Te nanometer material comprises the following steps: taking selenium telluride as a raw material, carrying out chemical vapor deposition on the surface of a substrate, adjusting the temperature of the substrate to 200-400 DEG C, and carrying out heat preservation for 2-4 hours, so as to obtain the Van der Waals Te nanometer material. The Van der Waals tellurium nanometer material is obtained; the chemical vapor deposition is carried out under the condition of introducing nitrogen. The Van der Waals tellurium nano material has a wide spectrum (from visible light to near-infrared light) for optical nerve regulation, the wave band can reach the near-infrared IIa (1.3-1.4 microns) wave band, and under the irradiation of 1.31 microns of light of the near-infrared IIa, mouse cortical nerve cells can be successfully induced to generate action potential.

The invention relates to the technical field of bioactive peptides, and discloses a walnut peptide with a neuroprotection function and a preparation method and application thereof, and predicts that a batch of small molecular walnut peptides have the neuroprotection function through enzymolysis of natural walnut protein, molecular weight screening and molecular docking. Experiments prove that the walnut peptide disclosed by the invention has a nerve protection function: the cell activity of nerve cells is improved, and the walnut peptide plays a role in preventing neurodegenerative diseases and other nerve-related diseases; the toxic effect of oxidative damage on nerve cells is relieved, nerve cell apoptosis is inhibited, the cell viability of the nerve cells is improved, and the function of treating nerve injury related diseases is achieved; the compound can be used for improving the activity of nerve cells, relieving oxidative damage of the nerve cells, adjusting the protein level of nerve damage related pathways, preparing related drugs for reducing blood pressure or resisting senile dementia or tumors and the like, and has a wide application prospect.

The invention relates to the technical field of related drugs for nerve injury caused by heavy metal pollution, in particular to application of a compound for inhibiting phosphorylation of ARMC10 in preparation of drugs for antagonizing tin-induced nervous system injury. Exposure of trimethyltin chloride induces nerve cell mitochondrial dysfunction, and the key mechanism is ARMC10 serine 43 site abnormal phosphorylation. Phosphorylated protein causes excessive mitochondrial fission, membrane potential collapse and energy metabolism disorder, resulting in neuron damage. Based on the target spot, a compound for antagonizing tin-induced nervous system injury is obtained through screening, protein phosphorylation can be specifically inhibited, mitochondrial dynamic unbalance and dysfunction induced by trimethyltin chloride are effectively reversed, and neurotoxicity is relieved. According to the technical scheme, the technical problem that in the prior art, no medicine for effectively antagonizing tin-induced nervous system injury exists can be solved, and the compound has the application potential for treating the nervous system injury and cognitive impairment caused by tin exposure.

The invention discloses a nerve cell senescence resisting medicine containing p-hydroxybenzaldehyde and application thereof.The p-hydroxybenzaldehyde is adopted as the only active substance, and the p-hydroxybenzaldehyde can reduce accumulation of DNA damage in cells, reduce activity of beta-galactosidase in the cells and slow down reduction of cell metabolic capacity, so that the nerve cell senescence resisting medicine is obtained. Therefore, the senescence of nerve cells is effectively slowed down, the cognitive function is improved, and a potential treatment effect is achieved in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

To provide an optogenetic neural probe device with multiple inputs and outputs by focusing optogenetic neural probe manufacturing technology utilizing an optical semiconductor device process, and a method of manufacturing the same.SOLUTION: An optogenetic neural probe device 10 includes: an optical device alignment substrate 100; an optical device group 200 disposed on the optical device alignment substrate 100 and including multiple optical devices 210; an optical neural probe substrate 310; and an optical signal input / output port 323 positioned in proximity to a nerve cell on the optical neural probe substrate 310. An optical signal emitted from the optical device group 200 is transmitted to the optical signal input / output port 323 through an optical waveguide 322 present on the optical neural probe substrate 310.SELECTED DRAWING: Figure 1a

The invention belongs to the technical field of drug development, and particularly relates to application of (E)-N-benzyl-2-((5-(thiophenyl) furan-2-yl) methylene) hydrazine-1-thioformamide in preparation of drugs for treating nervous system diseases. The invention aims to provide a medicine which has small toxic and side effects and can target SLC11A2 to treat or improve nerve cell injury. According to the technical scheme, the invention relates to application of (E)-N-benzyl-2-((5-(thiophenyl) furan-2-yl) methylene) hydrazine-1-thioformamide in preparation of a medicine for treating nervous system diseases, in particular to application of (E)-N-benzyl-2-((5-(thiophenyl) furan-2-yl) methylene) hydrazine-1-thioformamide. It is proved that the compound (E)-N-benzyl-2-((5-(thiophenyl) furan-2-yl) methylene) hydrazine-1-thioformamide is small in toxic and side effect, and nerve cell damage can be protected or improved by targeting SLC11A2; and a new choice is provided for treating or improving nerve cell injury.

The invention discloses an application of a polypeptide in preparation of a medicine for preventing or treating cerebral apoplexy. The polypeptide comprises an amino acid sequence as shown in SEQ ID NO: 1. The N15 polypeptide expressed by the sequence can inhibit apoptosis and autophagy of damaged neurons by inhibiting expression of Tom20 and PARP proteins, promote expression of SYN-1 protein to promote a patient with ischemic cerebral apoplexy to recover learning, memory and cognitive functions, can comprehensively protect neuronal damage caused by ischemic cerebral apoplexy, can promote recovery of damaged nerve cells of an OGD model, and has a good application prospect. The polypeptide has an obvious protection effect on neuronal cells, the polypeptide is connected with a cell transmembrane carrier and can penetrate through a blood brain barrier to enter brain tissue to directly act on the neuronal cells, and an ischemic cerebral apoplexy animal model verifies that the polypeptide has an effect of treating cerebral apoplexy. Particularly, the cognitive ability and learning and memory ability of a mouse with cerebral arterial thrombosis can be recovered to a normal level, and a good treatment effect on cerebral arterial thrombosis is achieved.

The invention relates to a method for promoting nerve cell proliferation and differentiation based on ultrasonic stimulation and application, and belongs to the technical field of biomedicine. According to the method, under the conditions that the power is 90-110 mW and the frequency is 0.9-1.1 MHz, nerve cells are continuously stimulated for 3 days by ultrasonic waves once per day, and each time lasts for 2-4 min. The purposes of increasing the nerve cell proliferation speed and promoting nerve cell differentiation are achieved only through ultrasonic stimulation under specific conditions for the first time, no other substances are added, non-invasion and non-contact are achieved, and toxic and side effects on cells are low; the nerve cells are not subjected to invasive or modified operation; the method has a wide application prospect only through physical conditions.

The invention provides a fermented beverage capable of relieving fatigue and a preparation method of the fermented beverage, and relates to the technical field of functional beverages, and the IPC classification number belongs to A23L2. The fermented beverage is prepared from a radix astragali fermentation extract, a radix platycodonis extract, L-arginine, taurine, inositol, caffeine, nicotinamide, vitamin B6, L-lysine hydrochloride, pyrroloquinoline quinone and auxiliary materials. The astragalus mongholicus fermentation extract can improve the ATP generation efficiency, reduce lactic acid accumulation after exercise, relieve damage of oxidative stress to muscle and nerve cells and reduce immunosuppression caused by fatigue; the platycodon grandiflorum extract has the effects of refreshing mind and restoring consciousness, improving cognitive function decline caused by central fatigue, enhancing capillary permeability and promoting removal of metabolic wastes. The radix astragali fermentation extract and the radix platycodonis extract are compounded to achieve a synergistic effect, so that the composition has an excellent anti-fatigue effect. Under the combined action of all the components, fatigue is relieved, energy is rapidly supplemented, and physical strength is recovered.