251results about "Monocomponent fibroin artificial filament" patented technology

The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.

The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.

A process for producing non-woven silk fiber fabrics comprises the following steps: a) obtaining silk fibroin, for example either from silk cocoons, or silk textiles or waste silk; b) removing the sericin layer covering the silk fibroin fibers, when present; c) breaking the disulfide bonds between heavy (350 kDa) and light (27 kDa) chains of silk fibroin in order to obtain the production of chain fragments which serve as a specific cellular recognition sites promoting the attachment and growth of cells, d) homogenising of the material resulting from step c).

The invention provides a method for preparing graphene/ silk composite fiber. The method comprises the steps of: oxidizing graphite powder by using acid, and carrying out ultrasonic dispersing and stripping to obtain graphene solution; mixing the obtained graphene solution with degummed silk fibroin and formic acid to obtain spinning solution; and carrying out electrospinning on the spinning solution by an electrostatic spinning device to obtain the graphene/ silk composite fiber. The method is simple in preparation technology, can effectively improve the mechanical property of the silk fiber and is easy to popularize and use.

An artificial polypeptide fiber of the present invention is an artificial fiber containing a polypeptide as a main component, and has a stress of 350 MPa or more and a toughness of 138 MJ/m³ or more. A method for producing an artificial polypeptide fiber of the present invention is a method for producing the artificial polypeptide fiber obtained by spinning a spinning solution (6) containing a polypeptide derived from natural spider silk proteins and performing drawing of at least two stages. The drawing of at least two stages includes a first-stage drawing (3) in wet heat and a second-stage drawing (4) in dry heat. Thereby, the present invention provides high-toughness artificial polypeptide fibers having favorable stress and rupture elongation, and a method for producing the same.

An apparatus and method for forming liquid spinning solution into a solid formed product whereby the solution is passed through at least one tubular passage (17) having walls formed at least partly of semipermeable and/or porous material. The semipermeable and/or porous material allows parameters, such as the concentration of hydrogen ions, water, salts and low molecular weight, of the liquid spinning solution to be altered as the spinning solution passes through the tubular passage(s).

The invention belongs to the technical field of composite materials and particularly provides a fibroin-silver-nanoparticle composite material and a preparation method thereof. The fibroin-silver-nanoparticle composite material comprises fiber (including electrospinning fiber), film, hydrogel and three dimensional porous materials. The preparation method comprises the following steps: after fibroin solution and silver nitrate solution are mixed, the precursor of silver is converted into silver-nanoparticles through in-situ reduction under the irradiation of sunlight or simulated sunlight, and then the material is formed and prepared; or fibroin is prepared into different forms of materials first, then the materials are soaked in silver nitrate water solution, and finally, the precursor of silver is converted into silver-nanoparticles through in-situ reduction under the irradiation of sunlight or simulated sunlight. According to the invention, fibroin is taken as material matrix and the reducing agents and stabilizing agents of silver-nanoparticles, and no other chemical agent is required to be added; and the preparation process is simple, energy-saving and environment-friendly, and the material has various forms.

The invention relates to a method of improving the bacterinertness of a silk fibroin solution. Silk fibroin material has favorable prospects when applied in biomedicine aspect, and thus the search of a method of improving the bacterinertness of silk material is meaningful. The invention comprises a silk fibroin solution preparing working procedure which adopts silk fibroin to prepare the silk fibroin solution and is characterized by also comprising a nanometer noble metal feeding working procedure by selecting nanometer noble metal with the grain diameter between 5 nanometers to 100 nanometers. When a temperature is between 0 DEG C to 50 DEG C, the nanometer noble metal is fed to a stand-by silk fibroin solution and is stirred at a rotating speed of 100-400 round/min to obtain the silk fibroin solution comprising the nanometer noble metal; the concentration of the silk fibroin is 0.5-15w/v percent, and the concentration of the nanometer noble metal is 0.005-0.2w/v percent. The invention can favorably improve the antibiotic performance of the silk fibroin solution so that the silk fibroin can be more widely applied to biological material.

The production process of superfine regenerated silk protein fiber features that silk protein is first dissolved in inorganic salt, the solution is desalted and concentrated to produce high concentration and high spinnability regenerated silk protein aqua, and the aqua is electrostatically spun directly into the superfine regenerated silk protein fiber. The fiber has excellent performance, has stable silk protein-II crystal structure without need of post-treatment. The present invention uses water without toxicity and harm as solvent to make the superfine fiber good in biocompatibility and suitable for use as biomedicine material. The present invention has wide material source including common silk and silk leftover, and the product of superfine regenerated silk protein fiber has its specification regulated with the use.

The natural silk can be used as main raw material, and is undergone the processes of degumming, dissolution and purification to obtain silk extract protein solution, then the wet spinning process is adopted and its controlled degree of crystallization is less than 40% and the fibre which can be made into bio-degradable tissue engineering scaffold can be spun. Said fibre possesses good biological compatibility.

The invention relates to a preparation method of regenerative silk protein fiber with skin-core structure, comprising the following steps: (1) silkworm cocoon is degummed and is dissolved in LiBr solution, a multi-wall carbon nano tube, a single-wall carbon nano tube or carbon black is added to obtain the solution with 20-35 percent of concentration; (2) sericin powder is prepared into the solution with 50-70 percent of concentration; (3) the solution is respectively poured into an inner pipe and an outer pipe of a coaxial spinning nozzle to carry out coaxial electrostatic spinning. The preparation method is simple, the operation is convenient, the cost is low, the method has no pollution to environment, and the obtained regenerative silk protein fiber has similar composition and skin-core structure with the natural silk.

The present invention relates to the processes of preparing silkfibroin/polyethylene oxide blended materials, and the resulting materials thereof, which are suitable for biomedical applications such as wound healing. In particular, the electrospun silk fibroin/PEO mats with a silk:PEO blend ratio of 2:1 to 4:1, treated with controlled evaporation, constraint-drying techniques, and/or alcohol treatment, and/or PEO extraction, demonstrate suitable physical and biofunctional properties, such as fiber structure, topography, absorption, water vapor transmission rates, oxygen permeation, and biodegradability, relevant to biomaterial systems with utility for wound dressings.

This invention is a rebirth silk fibre and preparation method. Silk is broad use because of excellent mechanics capability. But the produce is work force denseness and high cost. This invention take the raw material used high chroma rebirth silk protein water liquor (10-40%) with filature former liquor from industry scrap silk to process wet way filature. And adopt pure compound or multi-pure polymer water liquor to process concreting. This invention have some trait: abroad raw material source, high capability rebirth silk fibre, low cost, blare of nature silk and simple filature process, green environment protecting. In this method, rebirth silk fibre's rupture intention can get 0.1~1.0Gpa and its rupture elongate rate can be 10%-60%.

A method and an apparatus for the manufacture of a single silk mono-filament. The single silk mono filament has a tensile strength of above 40 Newtons. The single silk mono-filament has applications as a musical string or a medical device.

The invention discloses an antibacterial composite nanofiber membrane as well as a preparation method and an application thereof. The antibacterial composite nanofiber membrane comprises a nanofiber membrane and g-C3N4 nanosheets distributed on the surface and inside of nanofiber membrane. The invention also discloses the preparation method of the antibacterial composite nanofiber membrane and theapplication of the antibacterial composite nanofiber membrane. Compared with the prior art, the nanofiber membrane with antibacterial and filtering functions can be prepared only from a graphite phase carbon nitride particle material with a plasma technology, and the nanofiber membrane with an antibacterial function and a filtering function can be prepared, and has low resistance and high efficiency. Meanwhile, the preparation process of the antibacterial composite nanofiber membrane is safe and environmentally friendly, and the preparation method is simple and feasible.