18388 results about "Stabilizing Agents" patented technology

In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful election of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within particles without any polymeric matrix therein.

The present invention comprises methods and compositions for antimicrobial silver compositions comprising silver nanoparticles. The present invention further comprises compositions for preparing silver nanoparticles comprising at least one stabilizing agent, one or more silver compounds, at least one reducing agent and a solvent. In one aspect, the stabilizing agent comprises a surfactant or a polymer. The polymer may comprise polymers such as polyacrylamides, polyurethanes, and polyamides. In one aspect, the silver compound comprises a salt comprising a silver cation and an anion. The anion may comprise saccharinate derivatives, long chain fatty acids, and alkyl dicarboxylates. The methods of the present invention comprise treating devices with the silver nanoparticle compositions, including, but not limited to, such devices as woven wound care materials, catheters, patient care devices, and collagen matrices. The present invention further comprises treatment of humans and animals wacr6ith the antimicrobial devices described herein.

The present invention comprises methods and compositions comprising metal nanoparticles. The invention comprises metal nanoparticles and surfaces treated with a metal nanoparticle coating. The present invention further comprises compositions for preparing nanoparticles comprising at least one stabilizing agent, one or more metal compounds, at least one reducing agent and a solvent. In one aspect, the stabilizing agent comprises a surfactant or a polymer. The polymer may comprise polymers such as polyacrylamides, polyurethanes, and polyamides. In one aspect, the metal compound comprises a salt comprising a metal cation and an anion. The anion may comprise saccharinate derivatives, long chain fatty acids, and alkyl dicarboxylates.

A fully curable jettable composition having a viscosity less than 30 cps at a temperature within the range of 15-180° C., more preferably at a temperature of 15-100° C., e.g. 60-80° C. the composition comprising: (A) at least one low viscosity reactive resin selected from the group consisting of compounds containing an oxetane ring, cycloaliphatic epoxy resins, tetrahydrofurans, hexahydropyrans and mono-functional (meth)acrylates, said resin having a molecular weight of not greater than 300 Daltons, e.g. 250 Daltons or less, and a viscosity at a temperature in the said range of less than 30 cps, e.g. 5 to 15 cps; (B) at least one higher viscosity resin selected from the group consisting of epoxy resins, compounds containing an oxetane ring and acrylates, which resin acts to thicken the low viscosity resin and strengthen a jetted deposit of the composition, the higher viscosity resin having: a viscosity greater than twice that of the low viscosity resin at the said temperature in the range stated above, and a functionality of greater than or equal to 2; (C) at least one curable toughener, preferably having a functionality of at least 2, such as hydroxy, epoxy, acrylic or other reactive functionalised polymer/oligomer (e.g. derived by functionalising poly(tetrahydrofuran), polycaprolactone, polycarbonate diol, or a dendrimeric polyol; (D) at least one initiator for the polymerisation of the resins, and (E) at least one stabiliser for delaying the curing of the resins of the composition; wherein the low viscosity resin is slower to react than the higher viscosity resin and acts to solvate the higher viscosity resin prior to curing and at least partly during curing and wherein at least 30% of the components A and B are cationically curable resins. The composition can be jetted from piezo electric printing heads under the control of a computer program to form a multi-layered article, e.g. a three dimensional article, in which the adjacent droplets merge and are cured homogeneously together.

The invention relates to technical fields of materials, chemical engineering and electronics, in particular to a cable material with a polymer substrate and CTR effect and a preparation method thereof. The temperature sensing cable material with CRT characteristics consists of thermoplastic polymer, a filling agent, a plasticizer, functional additives, a stabilizing agent, a flame retardant, a lubricant, an antioxidant and a processing agent, has the use temperature range between -30 and 150 DEG C, and can be applied on occasions such as recoverable line-type temperature sensing cables, fire prewarning and alarm devices, temperature measurement, overheating alarm and protection and the like. The temperature sensing cable material with the CRT characteristics takes a polymer material as a substrate, and is added with multiple organic and inorganic compounds with special CTR characteristics taken as the functional additives, and has the characteristics of flexibility, and capacities of being continuously processed and being used like a common cable material.

A rheology modifying copolymer composition containing a cross-linked copolymer of unsaturated carboxylic acid, a hydrophobic monomer, a hydrophobic chain transfer agent, a cross linking agent, and, optionally, a steric stabilizer, provides increased viscosity in aqueous electrolyte-containing environments.

The present invention relates to a stress stable lathering skin cleansing liquid composition comprising by weight parts of the liquid composition: (a) from about 0.5 parts to 10 parts of a stabilizer; for example trihydroxystearin; (b) from about 1 part to about 80 parts of lipid skin moisturizing agent; (c) from about 1 part to about 30 parts of surfactant having a combined CMC equilibrium surface tension value of from 15 to 50; (d) water; wherein said stress stable lathering skin cleansing liquid composition has a Lipid Deposition Value (LDV) of from about 5 to about 100 and wherein said composition is stable for at least two weeks at 100 F.

Particles comprising(a) a supercooled melt of a poorly water-soluble substance and(b) a stabilizing agent,which have a mean particle size of between 30 and 500 nm, and disperse compositions containing them, as administration forms and delivery systems for drugs, vaccines and other biologically active agents such as herbicides, pesticides, insecticides, fungicides, fertilizers, vitamins, nutrition additives and cosmetics.

A process comprising: reacting a silver compound with a reducing agent comprising a hydrazine compound in the presence of a thermally removable stabilizer in a reaction mixture comprising the silver compound, the reducing agent, the stabilizer, and an optional solvent, to form a plurality of silver-containing nanoparticles with molecules of the stabilizer on the surface of the silver-containing nanoparticles.

The invention discloses a wood-plastic composite material and a preparation method thereof, and the wood-plastic composite material comprises the following raw materials according to the mixing ratio by parts by weight: 30-80 parts of modified fiber powder; 15-80 parts of plastics; 2-10 parts of phase solvent; 2-10 parts of lubricant; 0-10 parts of stabilizer; 0.2-1.0 part of antioxidant; 5-15 parts of filler; and 2-20 parts of flame retardant. Lignin is utilized for modifying fiber powder, then composition with the plastics is carried out, and a finished-product material is formed by extrusion. The preparation method can solve the problems of the compatibility of wood fibers with the thermoplastic plastics, the surface treatment technology of the raw materials by utilizing the lignin and the like, realize the comprehensive utilization of the lignin and the waste plastics, be capable of replacing wood, increase the additional value of the lignin and solve the utilization problem of the lignin wastes. The manufactured wood-plastic composite material can significantly improve the mechanical performance, the tensile strength, the flexural strength and the impact resistance, and realize the industrial production of high-performance products, such as construction materials.

The invention provides aqueous alkaline compositions useful in the microelectronics industry for stripping or cleaning semiconductor wafer substrates by removing photoresist residues and other unwanted contaminants. The compositions typically contain (a) one or more metal ion-free bases at sufficient amounts to produce a pH of about 10-13 and one or more bath stabilizing agents having at least one pKa in the range of 10-13 to maintain this pH during use; (b) optionally, about 0.01% to about 5% by weight (expressed as % SiO2) of a water-soluble metal ion-free silicate; (c) optionally, about 0.01% to about 10% by weight of one or more chelating agents; (d) optionally, about 0.01% to about 80% by weight of one or more water-soluble organic co-solvents; and (e) optionally, about 0.01% to about 1% by weight of a water-soluble surfactant.

An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-β, BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions.

The invention relates to compositions effective for the cleansing of mammalian soft tissue optionally attached to bones, and particularly the removal of blood deposits and bone marrow therefrom. The compsotions are composed of an aqueous solution containing as its essential ingredients a detergent having a functionality of the nature of a polyoxyethylene-23-lauryl either, a detergent having a functionality of the nature of exyethylated alkylphenol, and water, where the compositions are free from any membrane stabilizers. The present invention is also directed to a method and composition for cleaning cadaveric soft tissue optionally attached to bone to produce soft tissue grafts optionally attached to bone suitable for transplantation into a human. The present method involves removing bone marrow elements, blood deposits and any bacteria, virus or fungi contamination, from the donor bone and/or associated soft tissues.

The invention relates to viable and stable probiotic formulations for intestinal targeting made of microspheres comprising each a core of one or more probiotic bacteria, microcrystallline cellulose with a degree of polymerization from 165-365 and mean diameter from 45 to 180 μm, a disintegrant and a stabilizer, the core being coated with a non-enteric coating and further coated with an enteric coating. Each probiotic microsphere has a residual moisture level of less than 5% and a water activity (a_w) between 0.1 and 0.5. Such a probiotic microsphere shows no reduction in viable bacteria after one hour in simulated gastric fluid. The present invention also relates to the process of preparing such formulation.

The invention discloses a halogen-free flame-retardant thermoplastic elastomer cable material with polyphenylether as the base materials and a preparation method thereof. The raw material of the cable material contains the components with the following weight percentage: 10 to 35 percent of matrix resin A; 5 to 15 percent of matrix resin B; 10 to 25 percent of elastomer; 5 to 25 percent of softening plasticizer; 8 to 15 percent of flame-retardant plasticizer; 20 to 40 percent of smoke-suppression flame retardant; 3 to 10 percent of compatilizer; 1 to 5 percent of lubricant; 1 to 5 percent of powder surface conditioner; 0 to 10 percent of mineral filler; 0.1 to 1 percent of stabilizing agent. The invention adds matrix resin, polyphenylether of strong polarity and functional group of styrene-ethylene / butylene-styrene segmented copolymer, which effectively improves the compatibility of non-polar elastomer with polyphenylether; the invention also adds plasticizer, which reduces the hardness of the material and increases the flexibility; and through the optimization and interaction of the softening plasticizer and the flame-retardant plasticizer, the invention reduces the hardness and improves the tactility of the material, and the flame retardant performance is excellent.

A liquid ink comprises (a) a carrier liquid having a Kauri-Butanol number less than 30; (b) a graft copolymer comprising a (co)polymeric steric stabilizer covalently bonded to a thermoplastic (co)polymeric core that is insoluble in the carrier liquid; and (c) a colorant, wherein the steric stabilizer comprises units derived from 3,3,5-trimethylcyclohexyl methacrylate, and the thermoplastic (co)polymeric core comprising units derived from at least a polymerizable monomer selected from the group consisting of (meth)acrylates having aliphatic amino radicals, nitrogen-containing heterocyclic vinyl monomers, N-vinyl substituted ring-like amide monomers, aromatic substituted ethylene monomers containing amino radicals, and nitrogen-containing vinylether monomers. The organosol provides improved liquid electrophotographic and electrographic ink compositions with improved dispersion stability, chargeability, and blocking resistance so that improved print quality or ink transfer performance are obtained.

Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.

A container assembly and method for storing, treating, transporting and stabilizing a biological sample includes a container, a closure member and a sample holder removably received in the container. The sample holder can be a platform-like device dimensioned to be supported on a ledge formed in the side wall of the container. The sample holder includes a central cavity for receiving the sample and immersing the sample in the stabilizing agent in the container. The closure member includes a body member to close the top end of the central cavity of the sample holder and to limit movement of the sample holder in the container. In another embodiment, the sample holder has a closure cap for closing the open top end of the cavity. The container includes a liquid reagent in an amount sufficient to treat the biological sample. The biological sample is retained in a predetermined containment area of the container to maintain the biological sample immersed in the reagent without regard to the orientation of the container.

Devices, systems, methods and kits for the collection, stimulation, stabilization and analysis of biological samples, including blood samples, are disclosed. An embodiment of the invention includes a container having a side wall, a bottom wall and a closure member defining an internal compartment having arranged therein a partition defining and fluidly separating first and second chambers in the internal compartment, the first chamber positioned in association with the closure member to receive the biological sample; in which at least one wall is constructed of an elastically deformable material; in which the first chamber contains at least one stimulating agent; in which the second chamber contains at least one stabilizing agent; and in which the first and second chambers can be placed in fluid communication by a user without opening or otherwise compromising the fluid integrity of the internal compartment.