277 results about "Long lasting" patented technology

Relating to the technical field of gene therapy, provided is an siRNA molecule for inhibiting PCSK9 expression, and use thereof. Particularly, an siRNA molecule for inhibiting PCSK9 expression (comprising a sense strand and an anti-sense strand that are complementary to form a double-stranded region) and a pharmaceutical composition comprising the same are disclosed. The siRNA molecule has a high silencing efficiency and a long-lasting silencing effect for PCSK9 gene, and is useful in the manufacture of products for inhibiting PCSK9 protein expression, products for reducing the concentration of low-density lipoprotein or low-density lipoprotein cholesterol in serum; and products for relieving the symptoms of PCSK9 gene-mediated diseases.

Surgical treatment of glaucoma involves creation of a sclerocorneal drainage channel, ensuring long-lasting controlled fluid flow and reduced intraocular pressure. Limitations relate to collateral damage to adjacent structures and outcomes being heavily reliant on the surgeon's expertise. The device described herein addresses such shortcomings. The device comprises a grasping body having a longitudinal axis, and a piercing member coupled to the grasping body, including an elongate body and a beveled piercing tip including a long side and a short side, wherein the piercing member includes a proximal segment, a distal segment, and an aperture nested between the proximal segment and the distal segment, wherein the short side and the aperture are coaxially disposed along a central longitudinal axis of the piercing member, and wherein the piercing member is configured to reciprocate along the longitudinal axis relative to the grasping body.

Provided are methods and composition for treating skin barrier functions and associated disorders. Formulated compositions may be applied on human skin to maintain a desired skin surface pH over an extended period of time without irritating the skin. Maintaining the desired surface pH aids in treatment of eczema, in addition to other skin conditions.

The invention discloses an efficient and lasting multifunctional refrigerator deodorant which comprises the following components: (a) 50-85wt% of a porous adsorption material with a high specific surface area; (b) 5-30 wt% of a catalyst capable of effectively catalyzing and decomposing organic odor molecules in a low-temperature environment of 0-10 DEG C; and (c) 3 to 15 weight percent of long-acting slow-release type broad-spectrum antibacterial agent. According to the efficient and lasting refrigerator deodorant and the preparation method thereof, the dual effects of physical adsorption and low-temperature catalytic decomposition are utilized, multiple types of peculiar smell molecules can be rapidly adsorbed and thoroughly decomposed, and the deodorization efficiency is remarkably higher than that of a single adsorbent; the service life is greatly prolonged and is 3-5 times that of common activated carbon, the food decay speed is reduced, the food fresh-keeping period is indirectly prolonged, and food safety is guaranteed. The use process is safe and reliable, the use is convenient, external conditions such as illumination and heating are not needed, the device can be directly placed in a refrigerator, the replacement frequency is reduced due to long-term effect, and the comprehensive use cost is low.

The invention belongs to the technical field of functional materials, and particularly relates to moisture power generation fabric and a preparation method and application thereof. The moisture power generation fabric comprises a fabric substrate modified with a conductive and hydrophilic reinforcing material, and a surface coating area of the fabric substrate is loaded with a moisture absorption power generation functional material. The proton transmission efficiency is improved through a specific charge transfer effect and an ion occupancy effect among components of the moisture absorption and power generation functional material, and the permanent asymmetric moisture absorption difference on two sides of a coupling interface of a coated area and an uncoated area is used as a stable driving force for proton transmission, so that lasting direct current output is formed. The power generation performance of the moisture power generation fabric is determined by power generation composite parameters (namely the product of stable power generation time and the sum of relative humidity and temperature under the same weight and the quotient of the product and the water evaporation difference value on the two sides of a coupling interface), and the power generation composite parameters and the power generation composite parameters are in a nonlinear relation of increasing and then decreasing. Therefore, the power generation performance of the moisture-induced all-weather sustainable power generation fabric can be quantitatively controlled and optimized by adjusting the power generation composite parameters.

The invention discloses a preparation method of a high-stability manual buffer solution, which comprises the following steps of: introducing two types of slow-release porous particle structures, namely a first type of particles loaded with acidic or alkaline components and a second type of particles loaded with silver nanoparticles, so that continuous slow release and dynamic adjustment of the components in the buffer solution are realized; the pH drift and the aging of a buffer system are effectively delayed; meanwhile, slow release of the silver nanoparticles endows the buffer solution with lasting antibacterial protection, microbial growth is remarkably inhibited, and due to the structural design, the long-term pH stability and storage safety of the buffer solution are remarkably improved, the clarity and physicochemical properties of the buffer solution are guaranteed, and the stability of the buffer solution is improved. The method greatly expands the application range in the fields of high-requirement biological experiments, medical detection, long-term sample storage and the like, the particle addition amount and the component proportion can be flexibly adjusted according to actual requirements, the method adapts to different pH ranges and application scenes, and various experiment requirements of protein purification, long-term sample storage, high-sensitivity analysis and detection are met.

The disclosure provides method of treating cancer in a patient in need thereof, comprising safely and efficaciously administering to the patient PLX038, a long lasting-PEGylated prodrug of the topoisomerase I inhibitor. The disclosure further provides combination therapies of PLX038 with inhibitors of the DNA damage response (DDR).

A circadian rhythm-based time-sharing repair formula and use thereof. A day composition focuses on anti-oxidation, stress resistance and energy metabolism to resist oxidative damage and enhance day vitality and provide long-lasting antioxidation protection. A night composition focuses on DNA repair, anti-inflammation and nerve relaxation to promote cell regeneration and repair and continuously support night repair. The composition of the day composition and the night composition designed according to the circadian rhythm of human metabolism causes the corresponding activities to take effect at the best time, and components are designed to cooperate with each other according to different physiological needs during the day / night, which can greatly improve the anti-aging effect.

The invention relates to the technical field of cosmetics, in particular to preparation and application of a cyclodextrin-coated azelaic acid oil-control skin-care product. Comprising the following steps: S1, adding deionized water into a mixer, adding a cyclodextrin-azelaic acid inclusion compound, nicotinamide and allantoin, mixing to obtain a water phase, mixing glycerol, caprylic / capric triglyceride, polydimethylsiloxane, polysorbate-80 and tocopheryl acetate to obtain an oil phase, slowly adding the oil phase into the water phase, and shearing and emulsifying to obtain a nanoemulsion; and S2, cooling the nano-emulsion, adding carbomer while stirring, continuously cooling to room temperature, sequentially adding phenoxyethanol, ferulic acid, menthol and essence, adjusting the pH value of the emulsion with triethanolamine, homogenizing, defoaming, disinfecting and filling. By adjusting the proportion of the components in the formula, the skin feeling of the product can be further optimized, so that the product is more comfortable and not greasy, and a lasting oil control effect is provided.

The disclosure provides method of treating cancer in a patient with ATM-deficient or ATR-deficient tumors, comprising safely and efficaciously administering to the patient PLXO38, a long lasting-PEGylated prodrug of the topoisomerase I inhibitor. The disclosure further provides combination therapies of PLXO38 with inhibitors of the DNA damage response (DDR).

The invention relates to a composition with a permeation enhancing effect and application thereof. The composition is prepared from the following components in parts by weight: 10 to 15 parts of ethoxydiethylene glycol, 10 to 15 parts of isosorbide dimethyl ether, 5 to 10 parts of folium artemisiae argyi extract and 1 to 6 parts of tea tree essential oil. According to the permeation enhancing composition, traditional azone easy to sensitize and ethyl alcohol easy to cause stimulation are abandoned, the efficient, safe and lasting permeation effect is finally achieved, and the permeation enhancing composition meets the high-activity component delivery requirement of cosmetics.

The invention discloses a protective base film for a polaroid and a preparation method of the protective base film, and belongs to the technical field of optical display equipment protective films. The protective base film comprises an antistatic PET base material layer and a self-adhesive layer, the antistatic PET base material layer is prepared by blending optical-grade PET slices and antistatic master batches, the master batches are prepared by taking ionic liquid dihydric alcohol as a comonomer, and the base film is endowed with lasting and stable intrinsic antistatic performance; the self-adhesive layer is formed by melting and blending a polyurethane acrylate prepolymer, a modified montmorillonite filler, other matrix materials and auxiliaries according to a specific ratio and carrying out an online UV curing process. Through innovative material design and an integrated forming process, the prepared protective base film has excellent optical transparency, lasting antistatic property, appropriate bonding strength, clean stripping property and outstanding damp-heat aging resistance, the comprehensive performance is remarkably superior to that of a traditional gluing protective film, and the production process is more environment-friendly and efficient.

The invention discloses an antiskid antibacterial ceramic tile and a preparation method thereof, and belongs to the technical field of ceramic materials. Through the unique design of the green body layer, the composite functional layer and the surface treatment layer, the anti-skid and antibacterial ceramic tile achieves good anti-skid and lasting antibacterial performance. The raw material formula of the green body layer, such as kaolin, silicon carbide micro powder and the like, is reasonably proportioned, so that the basic strength and stability of the ceramic tile are ensured. In the composite functional layer, zinc phosphate coated nano-zinc oxide and silver-loaded zeolite are key antibacterial materials, and the ceramic tile has an efficient and lasting antibacterial effect under the combined action of the zinc phosphate coated nano-zinc oxide and the silver-loaded zeolite. The surface treatment layer is formed by carrying out gradient concentration treatment on anti-skid liquid containing an organic metal framework material, the anti-skid antibacterial ceramic tile solves the problems that a traditional ceramic tile is insufficient in anti-skid performance and not lasting in antibacterial effect, can be widely applied to various public places and home decoration, and provides a safe and sanitary living and working environment for people.

A glueless dustless composite flooring material system providing PVC-based flooring having waterproof layers providing different qualities of hardness, wear-resistance, sound deadening, and decorative patterns, avoiding the use of moisture-susceptible compressed dust filler, with layers fused together, avoiding the manufacturing complexity and delamination risks of using glue or adhesive, with a quickly-cured, UV-cured top coating providing long-lasting high performance and shortening and simplifying the manufacturing, which can be done in a sheet-form, essentially continuous-run manner, with an ability to quickly and simply change the optional design printing and texturing produced, and having an optional underlayment layer.

An ultra durable leather watch band that sets a new standard in the industry. The watch band has long lasting durability and provides light weight comfort. Specifically, the watch band has a leather upper layer, a nylon lower later, and stitching which effectively mates and secures the layers together to form an integral watch band. Preferably, the top layer is made from high performance top grain water proof leather, and the bottom layer is made of very rugged nylon webbing that adds durability, long life wear, comfort and repels moisture. Preferably, the stitching is both rugged and waterproof. To that end, the stitching may be high performance nylon.

The invention provides an inner hole plasma spraying high-bonding-strength bonding layer and Y2O3 coating material and a preparation technology thereof. The bonding layer comprises a middle transition layer formed after Si and C on the surface of a graphite matrix are subjected to a chemical reaction. The inner hole plasma spraying high-bonding-strength bonding layer provided by the invention is composed of a silicon carbide transition layer generated by in-situ reaction of molten silicon and carbon on the surface of a graphite matrix, and can form a Si-O-M bridged bond with a subsequent ceramic coating, so that interface bonding is converted into chemical bonding from mechanical anchoring, and the bonding strength is improved. And meanwhile, by utilizing the thermal expansion characteristic of silicon carbide between graphite and ceramic, the purposes of buffering thermal mismatch stress step by step on the atomic scale, blocking high-temperature diffusion of carbon elements and endowing the coating with lasting high bonding strength and thermal cycling stability are achieved.

Surgical treatment of glaucoma involves creation of a sclerocorneal drainage channel, ensuring long-lasting controlled fluid flow and reduced intraocular pressure. Limitations relate to collateral damage to adjacent structures and outcomes being heavily reliant on the surgeon's expertise. The device described herein addresses such shortcomings. The device comprises a body for grasping, a piercing member including a proximal segment and a distal segment, the distal segment including a piercing tip at a distal end thereof, and a distal stabilizer element extending from a distal end of the body, the distal stabilizer element including a lumen, wherein the piercing member is configured to reciprocate from a stored position, wherein the proximal segment is retracted within the stabilizer lumen and the piercing tip extends outwardly from the stabilizer, and an extended position, wherein the distal segment and at least a portion of the proximal segment extend outwardly from the stabilizer.

The invention relates to the field of coatings, in particular to an antibacterial formaldehyde-removing art coating and a preparation method thereof.The antibacterial formaldehyde-removing art coating is prepared from, by weight, 35-55 parts of organic silicon modified acrylic emulsion, 10-20 parts of filler, 3-8 parts of antibacterial formaldehyde-removing composite material, 5-10 parts of pigment, 0.1-0.3 part of defoaming agent, 0.1-0.5 part of dispersing agent, 0.2-0.6 part of thickening agent and 10-20 parts of deionized water. According to the prepared coating, the self-crosslinking type organic silicon modified acrylic emulsion is used, a compact and durable paint film can be formed, and stable support is provided for functional components. The antibacterial formaldehyde-removing composite material and the porous filler are introduced, formaldehyde and bacteria are physically adsorbed and enriched through a porous frame of the antibacterial formaldehyde-removing composite material and the porous filler, then a loaded bimetallic complex is used as an efficient catalytic center, formaldehyde is degraded into harmless substances, and meanwhile, the antibacterial formaldehyde-removing composite material also has an efficient and lasting broad-spectrum antibacterial effect.

A kind of fabric of lasting cool feeling, its structure includes breathable surface layer;Skin-friendly bottom layer, be located in the bottom surface of the breathable surface layer;A plurality of active contact type cool feeling structures are equipped on the skin-friendly bottom layer, adopt double-layer fabric with active contact type cool feeling structure, by breathable surface layer, with the skin contact skin-friendly bottom layer cooperate active contact type cool feeling structure to skin and carry out lasting cool feeling contact, even in fabric wrinkle place can actively contact with skin cool feeling, specifically, when external airflow enters breathing type notch by breathable surface layer, airflow will act on breathing cool feeling diaphragm, since the bottom of connecting piece is limited, so that breathing cool feeling diaphragm drives connecting piece top to change, the top of elastic silk column will be stretched and changed, the bottom end of breathing cool feeling diaphragm will be exposed breathing type notch, actively contact with skin.

The present invention provides long-lasting fragrance compositions that impart to a consumer a long-lasting perception and / or intensity of a perfume during fragrance wear. The present invention provides long-lasting fragrance compositions for prolonging the performance of a fragrance oil.

The present invention provides an active energy ray-curable antifogging coating composition capable of forming a cured film having long-lasting antifogging properties and excellent abrasion resistance, bleed resistance, adhesion, and damp heat resistance. The present invention also provides such a cured product and a laminate. The present invention relates to an active energy ray-curable antifogging coating composition including a radically polymerizable compound (A) having a structure of any of formulas (1) to (3) below, and a water-soluble surfactant (B); to a cured product of the active energy ray-curable antifogging coating composition; and to a laminate having a film including the cured product

The invention belongs to the technical field of ceramics, and particularly relates to a preparation method of antibacterial ceramics and an antibacterial ceramic product. The method comprises the following steps: firstly, preparing a ceramic matrix with a compact structure through wet co-grinding, molding and sintering; performing chemical vapor deposition on the surface of the substrate to form a layer of silicon dioxide film; then, a KH550 silane coupling agent is used for surface activation; finally, in the nitrogen atmosphere, 4, 4 '-bipyridine reacts with epoxy chloropropane to form a quaternary ammonium pyridine antibacterial layer on the surface through grafting. The antibacterial functional group is firmly anchored on the surface of the ceramic in a full chemical bonding manner, so that the problems that a traditional physical coating is easy to fall off and is not durable are solved. The obtained antibacterial ceramic has efficient, broad-spectrum and lasting antibacterial performance, the antibacterial rate is still kept at 98.8% or above after friction, and the antibacterial ceramic is suitable for the fields of daily supplies, building decoration, sanitary ware and the like.

The Abstract of this product is to provide a safe hard long-lasting chew for dogs. There is no choking hazard as it is liquid that's dried. Any dog of any size or age can safely consume the product.

The utility model relates to the field of textile fabrics, in particular to a texture-feeling antibacterial fabric, which is characterized in that warp yarns are wool / polyester / wormwood fiber blended yarns, weft yarns are wool / wormwood fiber / polyester blended yarns, the fabric adopts warp textures, the number of texture circulation warp yarns is 8, and the number of texture circulation weft yarns is 8. Specifically, warp yarns a, b, c and d are interwoven with weft yarns IV, V, VI, VII and VIII to form warp-direction long floating threads; as the number of interweaving points is small, the weaving shrinkage rate is small, and the length of the warp long floating threads is raised; the warp yarns e, f, g and h and the weft yarns I, II, III, IV and VIII form warp-direction long floating threads; the warp yarns a, b, c and d and the weft yarns I, II, III and IV are interwoven to form short floating threads; the warps e, f, g and h and the wefts V, VI, VII and VIII are interwoven to form short floating threads; the long floating threads and the short floating threads are gradually transitioned and arranged at intervals in one texture cycle, so that a regular convex point-shaped appearance at the long floating threads is formed, and the fabric shows texture feeling in appearance. According to the fabric, the long floating threads and the short floating threads are gradually transitioned and arranged at intervals through texture changes, the fabric protrudes at the long floating threads, regular protruding dot-shaped appearance is formed, the style is high, and meanwhile the fabric is endowed with a lasting antibacterial effect due to the addition of the wormwood fibers. The fabric manufactured by the utility model can be suitable for spring and summer jackets and the like.

The invention relates to the technical field of printing ink curing coatings, and discloses a preparation method of an external wall stone-imitating thermal insulation coating. The coating is prepared from the following components in parts by mass: 30 to 50 parts of acrylic emulsion, 8 to 20 parts of glass powder, 5 to 15 parts of ceramic powder, 15 to 30 parts of natural stone powder, 10 to 25 parts of sand grains, 0.3 to 1.2 parts of thickening agent, 0.5 to 1.5 parts of wetting dispersant, 1.5 to 3.5 parts of coalescing agent, 1 to 5 parts of mildew-proof weather-proof agent and 50 to 80 parts of water. By adding the glass powder, the ceramic powder and other components, a microcosmic heat insulation layer is formed in the coating, heat conduction is effectively reduced, energy consumption of a building is reduced, and a good heat insulation effect is achieved. The mildew-proof and weather-proof agent is a brand new compound, and long-acting bacteriostasis is realized by destroying cell walls of mildew or interfering a metabolic enzyme system of the mildew. The mildew-proof coating has high stability in a humid environment, is not easy to decompose, and can provide lasting mildew-proof protection for buildings.

The present invention belongs to the field of pesticide insecticide technology and discloses an insecticidal composition and its use. The insecticidal composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is oxazolidinone, and the active ingredient B is any one of flufenacet, isoxazolidinone, or flufenacet. The mass ratio of the active ingredient A to the active ingredient B is 1:55 to 50:1. The composition of the present invention rationally combines compounds with different mechanisms of action, so that the resulting composition has a beneficial effect on the control effect, expands the insecticidal spectrum, has good fast-acting properties, and has a long lasting effect.

The invention discloses an anti-static and anti-abnormal-sound coating for a durable automobile sealing strip and a preparation method of the anti-static and anti-abnormal-sound coating in the field of functional coating materials. The coating is prepared from hydroxy acrylic resin, two special functional fillers, auxiliaries and a solvent. Wherein the vinyl functionalized polypyrrole-silver nanowire hybrid conductive fiber provides a lasting static dissipation path, and the epoxy siloxane grafted perfluoropolyether solid lubricating particles provide long-acting lubrication through chemical bonding so as to eliminate abnormal sound. When the coating is prepared, the resin and the adhesion promoter are dissolved in the mixed solvent to form a resin liquid, then the two functional fillers and the lubricating additive are added after being pre-dispersed, and finally the mixture and the cross-linking agent are mixed and cured. The coating is firmly attached to the surface of the sealing strip through chemical bonding and endows the sealing strip with stable and lasting anti-static, noise-reducing and wear-resisting performance, and the process is simple and convenient and suitable for large-scale production.

The invention relates to a preparation method of a high-performance PAE wet strength agent, and belongs to the technical field of papermaking additives. The high-performance PAE wet strength agent is prepared from a self-made cross-linking agent, diethylenetriamine, a catalyst, deionized water and adipic acid as raw materials, the cross-linking agent is prepared by modifying epoxy chloropropane, the prepared cross-linking agent does not contain an organochlorine structure, the problem of organochlorine residues existing in the PAE wet strength agent can be thoroughly solved, and in addition, the PAE wet strength agent has the advantages that the preparation process is simple, and the production cost is low. Compared with a traditional wet strength agent, the cross-linking agent disclosed by the invention has the advantages that the curing temperature is lower, the damage of high temperature to a fiber structure can be effectively reduced, the flexibility of paper is reserved, and in addition, the cross-linking agent disclosed by the invention also has a pyridyl quaternary ammonium salt structure and can be combined in the paper to play a lasting antibacterial effect after pulp preparation and curing.

1. The name of the design product: toothpaste box (long-acting refreshing and deodorizing toothpaste). 2. The use of the design product: the design product is used for the outer package of toothpaste products. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective view.

The invention discloses a solid beer-flavor effervescent tablet and a preparation method thereof. The solid beer-flavor effervescent tablet comprises an acid source, an alkali source, a beer-flavor matrix, a sweetening agent, a filling agent, a nutrition enhancer and a processing aid, wherein the acid source comprises anhydrous citric acid, and the alkali source comprises sodium bicarbonate; the beer flavor matrix comprises malt flour, a humulus lupulus extract and a flavor enhancer, and the flavor enhancer comprises flavor essence and concentrated guava juice; the nutrition enhancer comprises vitamin B, mineral salt and an amino acid composition. According to the invention, rich and pure beer flavor and rich, fine and lasting foam can be generated after the beer is disintegrated in water, and the beer has good portability and long shelf life, and has a nutrition supplementing function.