457 results about "Long lasting" patented technology

Relating to the technical field of gene therapy, provided is an siRNA molecule for inhibiting PCSK9 expression, and use thereof. Particularly, an siRNA molecule for inhibiting PCSK9 expression (comprising a sense strand and an anti-sense strand that are complementary to form a double-stranded region) and a pharmaceutical composition comprising the same are disclosed. The siRNA molecule has a high silencing efficiency and a long-lasting silencing effect for PCSK9 gene, and is useful in the manufacture of products for inhibiting PCSK9 protein expression, products for reducing the concentration of low-density lipoprotein or low-density lipoprotein cholesterol in serum; and products for relieving the symptoms of PCSK9 gene-mediated diseases.

Surgical treatment of glaucoma involves creation of a sclerocorneal drainage channel, ensuring long-lasting controlled fluid flow and reduced intraocular pressure. Limitations relate to collateral damage to adjacent structures and outcomes being heavily reliant on the surgeon's expertise. The device described herein addresses such shortcomings. The device comprises a grasping body having a longitudinal axis, and a piercing member coupled to the grasping body, including an elongate body and a beveled piercing tip including a long side and a short side, wherein the piercing member includes a proximal segment, a distal segment, and an aperture nested between the proximal segment and the distal segment, wherein the short side and the aperture are coaxially disposed along a central longitudinal axis of the piercing member, and wherein the piercing member is configured to reciprocate along the longitudinal axis relative to the grasping body.

The invention discloses an anti-hair-loss composition, preparation thereof and application of the anti-hair-loss composition in hair washing and caring products, and belongs to the field of cosmetic preparation. The method for preparing the anti-hair-loss composition with the good and lasting anti-hair-loss effect comprises the following steps: (1) uniformly mixing arginine and citric acid, then adding diaminopyrimidine oxide, and continuously and uniformly mixing to form a mixture A; (2) uniformly mixing azelaic acid, nicotinamide and butanediol to form a mixture B; (3) uniformly mixing the mixture A, the mixture B, caffeine, a sanguisorba officinalis root extract, a green tea extract and a cacumen biotae extract to obtain the anti-hair loss composition. The anti-hair loss composition prepared by the invention is simple in component and simple in preparation process; the effect is lasting, and the anti-hair loss effect is good.

Provided are methods and composition for treating skin barrier functions and associated disorders. Formulated compositions may be applied on human skin to maintain a desired skin surface pH over an extended period of time without irritating the skin. Maintaining the desired surface pH aids in treatment of eczema, in addition to other skin conditions.

The invention discloses an efficient and lasting multifunctional refrigerator deodorant which comprises the following components: (a) 50-85wt% of a porous adsorption material with a high specific surface area; (b) 5-30 wt% of a catalyst capable of effectively catalyzing and decomposing organic odor molecules in a low-temperature environment of 0-10 DEG C; and (c) 3 to 15 weight percent of long-acting slow-release type broad-spectrum antibacterial agent. According to the efficient and lasting refrigerator deodorant and the preparation method thereof, the dual effects of physical adsorption and low-temperature catalytic decomposition are utilized, multiple types of peculiar smell molecules can be rapidly adsorbed and thoroughly decomposed, and the deodorization efficiency is remarkably higher than that of a single adsorbent; the service life is greatly prolonged and is 3-5 times that of common activated carbon, the food decay speed is reduced, the food fresh-keeping period is indirectly prolonged, and food safety is guaranteed. The use process is safe and reliable, the use is convenient, external conditions such as illumination and heating are not needed, the device can be directly placed in a refrigerator, the replacement frequency is reduced due to long-term effect, and the comprehensive use cost is low.

The invention belongs to the technical field of functional materials, and particularly relates to moisture power generation fabric and a preparation method and application thereof. The moisture power generation fabric comprises a fabric substrate modified with a conductive and hydrophilic reinforcing material, and a surface coating area of the fabric substrate is loaded with a moisture absorption power generation functional material. The proton transmission efficiency is improved through a specific charge transfer effect and an ion occupancy effect among components of the moisture absorption and power generation functional material, and the permanent asymmetric moisture absorption difference on two sides of a coupling interface of a coated area and an uncoated area is used as a stable driving force for proton transmission, so that lasting direct current output is formed. The power generation performance of the moisture power generation fabric is determined by power generation composite parameters (namely the product of stable power generation time and the sum of relative humidity and temperature under the same weight and the quotient of the product and the water evaporation difference value on the two sides of a coupling interface), and the power generation composite parameters and the power generation composite parameters are in a nonlinear relation of increasing and then decreasing. Therefore, the power generation performance of the moisture-induced all-weather sustainable power generation fabric can be quantitatively controlled and optimized by adjusting the power generation composite parameters.

The invention discloses a preparation method of a high-stability manual buffer solution, which comprises the following steps of: introducing two types of slow-release porous particle structures, namely a first type of particles loaded with acidic or alkaline components and a second type of particles loaded with silver nanoparticles, so that continuous slow release and dynamic adjustment of the components in the buffer solution are realized; the pH drift and the aging of a buffer system are effectively delayed; meanwhile, slow release of the silver nanoparticles endows the buffer solution with lasting antibacterial protection, microbial growth is remarkably inhibited, and due to the structural design, the long-term pH stability and storage safety of the buffer solution are remarkably improved, the clarity and physicochemical properties of the buffer solution are guaranteed, and the stability of the buffer solution is improved. The method greatly expands the application range in the fields of high-requirement biological experiments, medical detection, long-term sample storage and the like, the particle addition amount and the component proportion can be flexibly adjusted according to actual requirements, the method adapts to different pH ranges and application scenes, and various experiment requirements of protein purification, long-term sample storage, high-sensitivity analysis and detection are met.

The disclosure provides method of treating cancer in a patient in need thereof, comprising safely and efficaciously administering to the patient PLX038, a long lasting-PEGylated prodrug of the topoisomerase I inhibitor. The disclosure further provides combination therapies of PLX038 with inhibitors of the DNA damage response (DDR).

A circadian rhythm-based time-sharing repair formula and use thereof. A day composition focuses on anti-oxidation, stress resistance and energy metabolism to resist oxidative damage and enhance day vitality and provide long-lasting antioxidation protection. A night composition focuses on DNA repair, anti-inflammation and nerve relaxation to promote cell regeneration and repair and continuously support night repair. The composition of the day composition and the night composition designed according to the circadian rhythm of human metabolism causes the corresponding activities to take effect at the best time, and components are designed to cooperate with each other according to different physiological needs during the day / night, which can greatly improve the anti-aging effect.

The invention relates to the technical field of organic silicon elastomers, and discloses a preparation method and equipment of high-brightness organic silicon elastomer gel, and the high-brightness organic silicon elastomer gel comprises the following components in parts by mass: 124 parts of hydrogen-containing silicone oil and 13 parts of vinyl MQ resin. According to the invention, polydimethylsiloxane and isoalkane in a certain mass ratio are used as carrier fluids, and the polydimethylsiloxane and the isoalkane act together, so that the obtained product has more excellent silky feeling, matte feeling, smearing spreadability and skin feeling durability, can provide lasting velvet-like smooth feeling for the product, can bring matte and soft-focus effects for the product, and can be used for preparing a soft-focus soft-focus product. According to the present invention, the product viscosity can be reduced, the refreshing non-greasy skin feeling can be provided for the product, the product can be used as the high transparent system, the good smearing spreading degree and the good water resistance can be provided, the thickening effect can be provided in the anhydrous formula and the water-in-oil formula, and the product stability can be improved.

The invention relates to the technical field of cosmetics, in particular to preparation and application of a cyclodextrin-coated azelaic acid oil-control skin-care product. Comprising the following steps: S1, adding deionized water into a mixer, adding a cyclodextrin-azelaic acid inclusion compound, nicotinamide and allantoin, mixing to obtain a water phase, mixing glycerol, caprylic / capric triglyceride, polydimethylsiloxane, polysorbate-80 and tocopheryl acetate to obtain an oil phase, slowly adding the oil phase into the water phase, and shearing and emulsifying to obtain a nanoemulsion; and S2, cooling the nano-emulsion, adding carbomer while stirring, continuously cooling to room temperature, sequentially adding phenoxyethanol, ferulic acid, menthol and essence, adjusting the pH value of the emulsion with triethanolamine, homogenizing, defoaming, disinfecting and filling. By adjusting the proportion of the components in the formula, the skin feeling of the product can be further optimized, so that the product is more comfortable and not greasy, and a lasting oil control effect is provided.

The disclosure provides method of treating cancer in a patient with ATM-deficient or ATR-deficient tumors, comprising safely and efficaciously administering to the patient PLXO38, a long lasting-PEGylated prodrug of the topoisomerase I inhibitor. The disclosure further provides combination therapies of PLXO38 with inhibitors of the DNA damage response (DDR).

The invention relates to the technical field of polyethylene film preparation, in particular to an antistatic polyethylene composite film and a preparation method thereof.The polyethylene composite film is sequentially provided with a heat sealing layer, a blocking layer and a surface layer from inside to outside, and the surface layer and the heat sealing layer are prepared from, by weight, 55-65 parts of low-density polyethylene, 5-10 parts of polyethylene, 5-10 parts of polyethylene, 5-10 parts of polyethylene and 5-10 parts of polyethylene. 9-12 parts of ultra-high molecular weight polyethylene, 1-3 parts of a compatilizer, 6-10 parts of an antistatic agent and 8-15 parts of a flame retardant; and the barrier layer is made of ethylene-vinyl alcohol copolymer resin. The antistatic polyethylene composite film provided by the invention realizes excellent and lasting antistatic performance, the antistatic agent uniformly distributed in the film ensures rapid conduction and dispersion of electrostatic charges, and the problem of non-uniform antistatic performance is effectively solved; meanwhile, by introducing benzotriazole groups and silver nanoparticles, a stable antistatic network structure is formed, and the durability of the antistatic effect is greatly improved.

The invention relates to a composition with a permeation enhancing effect and application thereof. The composition is prepared from the following components in parts by weight: 10 to 15 parts of ethoxydiethylene glycol, 10 to 15 parts of isosorbide dimethyl ether, 5 to 10 parts of folium artemisiae argyi extract and 1 to 6 parts of tea tree essential oil. According to the permeation enhancing composition, traditional azone easy to sensitize and ethyl alcohol easy to cause stimulation are abandoned, the efficient, safe and lasting permeation effect is finally achieved, and the permeation enhancing composition meets the high-activity component delivery requirement of cosmetics.

The invention discloses a protective base film for a polaroid and a preparation method of the protective base film, and belongs to the technical field of optical display equipment protective films. The protective base film comprises an antistatic PET base material layer and a self-adhesive layer, the antistatic PET base material layer is prepared by blending optical-grade PET slices and antistatic master batches, the master batches are prepared by taking ionic liquid dihydric alcohol as a comonomer, and the base film is endowed with lasting and stable intrinsic antistatic performance; the self-adhesive layer is formed by melting and blending a polyurethane acrylate prepolymer, a modified montmorillonite filler, other matrix materials and auxiliaries according to a specific ratio and carrying out an online UV curing process. Through innovative material design and an integrated forming process, the prepared protective base film has excellent optical transparency, lasting antistatic property, appropriate bonding strength, clean stripping property and outstanding damp-heat aging resistance, the comprehensive performance is remarkably superior to that of a traditional gluing protective film, and the production process is more environment-friendly and efficient.

The present invention introduces a revolutionary Snap-On attachment system designed to transform the integration of wearable accessories into clothing, shoes, home articles, and accessories. This innovative system addresses the limitations of traditional attachment methods by providing a user-friendly, durable, and versatile solution that enables multiple installations and removals without causing damage to the fabrics and materials. To enhance customization, the invention introduces Snap-On sleeves with additional snap attachments, enabling users to add multiple accessories and personalize their garments to suit their preferences. These Snap-Ons are crafted from premium materials, ensuring long-lasting effectiveness and resistance to wear and tear, making them ideal for everyday use. Furthermore, the Snap-Ons provide branding opportunities for businesses and organizations, with customizable shapes, colors, raised letters, and other indicia allowing for distinctive visual representation and use as identification devices.

The invention discloses an antiskid antibacterial ceramic tile and a preparation method thereof, and belongs to the technical field of ceramic materials. Through the unique design of the green body layer, the composite functional layer and the surface treatment layer, the anti-skid and antibacterial ceramic tile achieves good anti-skid and lasting antibacterial performance. The raw material formula of the green body layer, such as kaolin, silicon carbide micro powder and the like, is reasonably proportioned, so that the basic strength and stability of the ceramic tile are ensured. In the composite functional layer, zinc phosphate coated nano-zinc oxide and silver-loaded zeolite are key antibacterial materials, and the ceramic tile has an efficient and lasting antibacterial effect under the combined action of the zinc phosphate coated nano-zinc oxide and the silver-loaded zeolite. The surface treatment layer is formed by carrying out gradient concentration treatment on anti-skid liquid containing an organic metal framework material, the anti-skid antibacterial ceramic tile solves the problems that a traditional ceramic tile is insufficient in anti-skid performance and not lasting in antibacterial effect, can be widely applied to various public places and home decoration, and provides a safe and sanitary living and working environment for people.

The utility model belongs to the technical field of nasal dredging patches, and particularly discloses an external magnetic type nasal dredging patch which comprises a pair of attaching pieces and a pair of fixing pieces which are used for being attached to the two sides of the nose, the pair of fixing pieces are connected through a supporting piece to form a U shape, the pair of attaching pieces are located between the pair of fixing pieces, and the pair of fixing pieces are located between the pair of attaching pieces. The adsorption inner sides of the pair of fixing pieces are in one-to-one corresponding magnetic adsorption connection with the pair of attaching pieces through magnets. According to the external magnetic type nasal dredging paste, the supporting piece is connected with the pair of fixing pieces to form a U shape matched with the shape of the nose of the human body so as to provide enough and lasting lifting force, and meanwhile, the pair of fixing pieces are connected with the pair of attaching pieces attached to the two sides of the nose through the magnets in a magnetic attraction mode respectively. Outward lifting force is applied to the skin near the nose bridge for a long time, so that the whole upper part of the nasal cavity can expand outwards for a long time, a nasal cavity channel is enlarged, the ventilation capacity is improved, nasal obstruction is relieved, and long-time comfortable experience is provided for a user.

The present invention relates to an anti-mite and antibacterial knitted fabric and a production process thereof, including weaving, cloth sorting, singeing, pre-treatment, polishing / dyeing one bath, post-treatment, wet slitting, drying and opening and finishing. Wherein: the singeing firepower is 21±0.5mbar, and the machine speed is 70±2m / min; the pre-treatment liquid contains 2g / L-3g / L Yajierui SCT-B, 6g / L-7g / L hydrogen peroxide, and the treatment temperature is 98±1℃; soaping is performed at a temperature of 95±1℃ for 15min-20min. The fabric of the present invention adopts natural pure cotton combed siro spinning as raw material, combined with double-sided jacquard structure weaving with specific needle length and line length, through specific singeing process and clean production short process and dyeing and finishing process technology, comprehensive post-finishing specific antibacterial and anti-mite finishing and softness and other process technology development, so that the designed fabric has a smooth and smooth appearance, is soft and comfortable, and has long-lasting antibacterial, anti-mite, anti-mosquito, health care and other properties.

This disclosure provides methods that render hydrophobic carbon fiber paper (CFP) hydrophilic for extended periods without damaging the carbon fibers that compose the CFP or the architecture of the network of those carbon fibers. The disclosure further provides hydrophilic CFP made by the inventive methods. The methods include sonicating the CFP in an aqueous surfactant solution followed by electrooxidizing the CFP in an aqueous electrolyte.

A glueless dustless composite flooring material system providing PVC-based flooring having waterproof layers providing different qualities of hardness, wear-resistance, sound deadening, and decorative patterns, avoiding the use of moisture-susceptible compressed dust filler, with layers fused together, avoiding the manufacturing complexity and delamination risks of using glue or adhesive, with a quickly-cured, UV-cured top coating providing long-lasting high performance and shortening and simplifying the manufacturing, which can be done in a sheet-form, essentially continuous-run manner, with an ability to quickly and simply change the optional design printing and texturing produced, and having an optional underlayment layer.

An ultra durable leather watch band that sets a new standard in the industry. The watch band has long lasting durability and provides light weight comfort. Specifically, the watch band has a leather upper layer, a nylon lower later, and stitching which effectively mates and secures the layers together to form an integral watch band. Preferably, the top layer is made from high performance top grain water proof leather, and the bottom layer is made of very rugged nylon webbing that adds durability, long life wear, comfort and repels moisture. Preferably, the stitching is both rugged and waterproof. To that end, the stitching may be high performance nylon.

The invention relates to a water-soluble whitening composition with good light stability as well as preparation and application of the water-soluble whitening composition. The composition is prepared from the following raw material components in parts by weight: 2.5 to 7.5 parts of phenylethyl resorcinol, 80 to 95 parts of a water-based solvent, 0.005 to 1 part of a pH regulator, 1 to 5 parts of a light protective agent, 1 to 5 parts of diglucosyl gallic acid and 0.1 to 1 part of sodium pyrosulfite. Compared with the prior art, the whitening composition disclosed by the invention can be basically not changed under daily irradiation, and can provide a lasting protection effect for phenylethyl resorcinol when being used in products for whitening and the like.

The invention discloses a radio frequency needle electrode structure for short-term implantation, which comprises an electrode tip, a hose, a connecting end electrode ring and an insulating part which are connected in sequence, a lead is connected between the electrode tip and the connecting end electrode ring; the temperature sensor is fixedly sealed in the electrode tip; the defects that an existing radio frequency electrode cannot be placed in a human body for a short time due to the fact that the outer diameter of the existing radio frequency electrode mostly adopts a metal tube hard electrode, repeated puncture is needed, and the comfort of a patient is poor are overcome; the diameter size is small, the operative wound is smaller, the patient feels comfortable, the device is soft and implantable, and the problem that the number of puncture times is too large due to periodic treatment is solved; meanwhile, the electrode is made of a flexible material, a temperature sensor is additionally arranged in the electrode, compared with a nerve stimulation electrode wire, larger energy can be output, and a more lasting curative effect is achieved under the assistance of the radio frequency heat effect.

The present invention is to provide a solid lip cosmetic which is excellent in secondary adhesion resistance effect and long lasting performance, and provides a good glossy finish.A solid lip cosmetic which has a secondary adhesion resistance effect and provides a good glossy finish can be prepared by blending a copolymer containing a dimer acid ester, or a copolymer containing a dimer acid ester and a dimer acid ester as an oil component adhering to lips (adhesive oil component) and a hydrocarbon oil which is liquid at room temperature as an oil component seeping into the surface when the cosmetic is applied to the lips (seeping oil component).

The invention provides an inner hole plasma spraying high-bonding-strength bonding layer and Y2O3 coating material and a preparation technology thereof. The bonding layer comprises a middle transition layer formed after Si and C on the surface of a graphite matrix are subjected to a chemical reaction. The inner hole plasma spraying high-bonding-strength bonding layer provided by the invention is composed of a silicon carbide transition layer generated by in-situ reaction of molten silicon and carbon on the surface of a graphite matrix, and can form a Si-O-M bridged bond with a subsequent ceramic coating, so that interface bonding is converted into chemical bonding from mechanical anchoring, and the bonding strength is improved. And meanwhile, by utilizing the thermal expansion characteristic of silicon carbide between graphite and ceramic, the purposes of buffering thermal mismatch stress step by step on the atomic scale, blocking high-temperature diffusion of carbon elements and endowing the coating with lasting high bonding strength and thermal cycling stability are achieved.

The tissue repair preparation at least comprises ECM, exosome and degradable glue, the ECM is an acellular matrix such as SIS, SIM and UBM, is granular and is injectable micro powder, and the content of the ECM is 10-50 mg / ml; the exosome is a healing-promoting cell, and is obtained by induction, polarization culture, centrifugation, supernatant collection and concentration and purification. The degradable glue is a polysaccharide with viscoelasticity; the advantages of a conventional filling agent are reserved, exosomes can be slowly released and internalized by various tissue cells, the activity of fibroblasts can be stimulated, the effect is lasting, and generation of new collagen is promoted; the defects of short effect and non-lasting effect of the existing filling agent are overcome; the product provided by the invention can achieve the effects of promoting rapid regeneration of collagen and maintaining for a long time; the functions of filling, face-lifting, tissue repairing and the like are achieved; the effect is remarkable, stable and lasting; the composition has multiple functions of quick effect, obvious effect and slow release and long-acting effect.

An antimicrobial composition that includes: an antimicrobial component having at least one quaternary ammonium compound; a synthetic polymer that includes: at least one cationic monomer Ab, optionally, at least one anionic monomer Ba, and optionally, at least one non-ionic monomer Ca; an organic acid; at least 20 wt. % of an organic polar solvent, preferably at least 30 wt. % of an organic polar solvent, based on a total weight of the composition; and a surfactant selected from cationic surfactants, amphoteric surfactants and combinations thereof, wherein the composition is free of non-ionic surfactants and the composition has a pH of at least 7. This composition when applied to a surface provides a combination of “quick-kill” efficacy and robust long lasting disinfection.

Surgical treatment of glaucoma involves creation of a sclerocorneal drainage channel, ensuring long-lasting controlled fluid flow and reduced intraocular pressure. Limitations relate to collateral damage to adjacent structures and outcomes being heavily reliant on the surgeon's expertise. The device described herein addresses such shortcomings. The device comprises a body for grasping, a piercing member including a proximal segment and a distal segment, the distal segment including a piercing tip at a distal end thereof, and a distal stabilizer element extending from a distal end of the body, the distal stabilizer element including a lumen, wherein the piercing member is configured to reciprocate from a stored position, wherein the proximal segment is retracted within the stabilizer lumen and the piercing tip extends outwardly from the stabilizer, and an extended position, wherein the distal segment and at least a portion of the proximal segment extend outwardly from the stabilizer.

The invention relates to the field of coatings, in particular to an antibacterial formaldehyde-removing art coating and a preparation method thereof.The antibacterial formaldehyde-removing art coating is prepared from, by weight, 35-55 parts of organic silicon modified acrylic emulsion, 10-20 parts of filler, 3-8 parts of antibacterial formaldehyde-removing composite material, 5-10 parts of pigment, 0.1-0.3 part of defoaming agent, 0.1-0.5 part of dispersing agent, 0.2-0.6 part of thickening agent and 10-20 parts of deionized water. According to the prepared coating, the self-crosslinking type organic silicon modified acrylic emulsion is used, a compact and durable paint film can be formed, and stable support is provided for functional components. The antibacterial formaldehyde-removing composite material and the porous filler are introduced, formaldehyde and bacteria are physically adsorbed and enriched through a porous frame of the antibacterial formaldehyde-removing composite material and the porous filler, then a loaded bimetallic complex is used as an efficient catalytic center, formaldehyde is degraded into harmless substances, and meanwhile, the antibacterial formaldehyde-removing composite material also has an efficient and lasting broad-spectrum antibacterial effect.