69 results about "Stimulant" patented technology

Exemplary olfactory delivery scaffolds may include 1) an olfactory targeting component, stimulant, or odorant that is recognized by the olfactory nerves via, for example, a smell response, 2) a molecule with biological activity, a therapeutic component, and / or drug (sometimes collectively referred to herein as a “therapeutic component”), and 3) a linker component that links the olfactory targeting component and therapeutic component together. The olfactory delivery scaffolds may be used to deliver a molecule with biological activity and / or a therapeutic component to a subject's neurological system through the olfactory pathway and pharmaceutical compositions useful in the treatment of neurological and / or neurodegenerative diseases.

The invention belongs to the technical field of chemical pharmacy, and particularly relates to a preparation method and application of an impurity of a beta2 adrenal receptor stimulant and M receptor antagonist bifunctional active compound. According to the impurity preparation method of the beta2 adrenal receptor stimulant and M receptor antagonist bifunctional active compound, acetylation of amino is successfully realized by using acetylation reagents such as acetyl chloride and alkali accelerators such as N, N-diisopropylethylamine, then debenzylation is performed through hydrogenation reaction, and the compound shown in the formula I is successfully prepared. Then, through liquid chromatography purification, a high-purity compound as shown in the formula I is obtained, and the raw material medicine as shown in JKN2304 can meet the requirements of reference substances in the research and development process; the technical problem that in the prior art, an impurity synthesis process of a beta 2 adrenal gland receptor agonist and M receptor antagonist bifunctional active compound is lacked is solved.

Exemplary olfactory delivery scaffolds may include 1) an olfactory targeting component, stimulant, or odorant that is recognized by the olfactory nerves via, for example, a smell response, 2) a molecule with biological activity, a therapeutic component, and / or drug (sometimes collectively referred to herein as a “therapeutic component”), and 3) a linker component that links the olfactory targeting component and therapeutic component together. The olfactory delivery scaffolds may be used to deliver a molecule with biological activity and / or a therapeutic component to a subject's neurological system through the olfactory pathway and pharmaceutical compositions useful in the treatment of neurological and / or neurodegenerative diseases.

The invention relates to a co-crystal or salt comprising psilocin and a co-former. The co-crystal or salt is useful in methods of treating or preventing a disease or condition selected from depression, anxiety, death anxiety, demoralization, adjustment disorders, hopelessness, suicidal ideation, desire for hastened death, cocaine-related disorders, opioid-related disorders and stimulant-related disorders in a patient. A kit comprising the co-crystal or salt is also described.

Described herein are new dual sigma receptor and dopamine transporter small molecule antagonists. As these compounds are antagonists of both sigma receptors and dopamine transporters, these compounds dose-dependently antagonize stimulant self-administration and also diminish the effects of stimulant effects on dopamine level, thus indicating minimal abuse liability.

Disclosed are a composition and method for the diagnosis of diseases accompanied by impaired glucose tolerance, comprising a material for ITIH1 detection. The composition and method according to the present application enable a relatively sensitive response even to small changes in blood sugar according to various stimulants in a hyperglycemic situation as compared to glycated hemoglobin (HbA1c) which is an existing diagnostic marker widely used for patients with diabetes, which is a typical disease accompanied by impaired glucose tolerance, and thus can more precisely detect blood sugar changes under various stress situations.

The invention relates to the technical field of cell detection kits, and particularly discloses a cell proliferation detection kit, which comprises: a base; the top seat is arranged above the base; the positioning assembly is connected with the partition plates and the top seat, so that the states of the partition plates can be conveniently adjusted, according to the cell proliferation culture requirements, drugs or irritants with different concentrations can be conveniently added into the reagent tubes, and an experimenter can move the top seat; the partition plates are simultaneously connected with the top seat and the base to form a parallelogram structure; the reagent tubes in the holes of the pore plate are inclined at the same time, so that an experimenter can add a reagent according to the reagent tubes which are inclined at the same time, the experiment process is simplified, the test efficiency is improved, the reagent is added by obliquely attaching the partition plate walls, bubbles can be prevented from being generated under the liquid level, and good wall attachment of the reagent is ensured; and the problems of aggregation and interference on experimental determination caused by severe oscillation of cells possibly caused by taking out the reagent tube are effectively avoided.

A neurite growth stimulant is a small molecule ENPP1 inhibitor. Small molecule ENPP1 inhibitors are capable of treating central nervous system (CNS) injury and promoting axonal regeneration. The ENPP1 inhibitor in the carrier can be administered at damaged nerves and their cell bodies to promote the regeneration of axons.

The invention discloses a method for preparing a biostimulant from a hydrothermal carbonization solution. The method comprises the following steps: hydrothermal carbonization of biomass wastes, dilution of the hydrothermal carbonization solution, domestication of activated sludge and enhancement of synergistic functional bacteria, and aerobic treatment. The invention also discloses an application effect of the hydrothermal carbonization liquid. By means of the method, substances which are toxic to crop growth in the hydrothermal carbonization liquid can be effectively removed, a biostimulant functional product which has a promoting effect on crop growth is prepared, the technological process is green and environmentally friendly, the raw material adaptability is wide, the technology is stable, and good application prospects are achieved.

A method for detecting an immune cellular response including the steps of: (a) suctioning a defined amount of the sample by an automated suction / discharge device, (b) discharging this amount, using the device, into container R, containing, beforehand, at least one stimulant for secretion of the molecule by the at least one cell, or else not containing such a stimulant, (c) when the container does not contain the stimulant beforehand, introducing into container R the at least one secretion stimulant contained in container E, using the device, and (d) allowing the sample and stimulant to incubate, forming a mixture, by the at least one cell (i) in container R or (ii) in another container S after suctioning and discharge of the mixture using the device, and (e) detecting the immune cellular response, the detection of the immune cellular response indicates the presence of an immune cellular response specific for the stimulant.

The invention relates to a medicine with drug rehabilitation and relapse prevention effects as well as a preparation method and application thereof, and belongs to the field of medicines. The medicine comprises rotundine and salts and is prepared through a chemical synthesis method, and experiments prove that the medicine preparation has the effects of treating opioid substances including heroin, morphine, dolantin, methadone and the like as well as other psychoactive substances, such as opioid and the like. Independent or addiction formed by cocaine, amphetamine stimulants, wine, smoke, cannabis sativa, sedative and hypnotic drugs and the like has the effects of detoxifying, relieving symptoms, inhibiting psychological craving and reducing relapse rate.

The invention discloses traditional Chinese medicine instant granules as well as a preparation method and application thereof. The traditional Chinese medicine instant granules are prepared from the following raw materials in parts by mass: 20-60 parts of traditional Chinese medicine components, 60-200 parts of a filling agent, 20-60 parts of a disintegrating agent and 5-30 parts of an adhesive. Different from traditional soluble granules, on one hand, the moisturizing-free instant granules are used for oral administration without a large amount of solvent, can be quickly dissolved in a very small amount of water, and can be almost completely dissolved within 5 seconds to form tiny granules; on the other hand, saliva irritants are not needed. The traditional Chinese medicine instant granules take traditional Chinese medicines as medicinal components, can contain various natural herbaceous plant micro powder or extracts, such as platycodon grandiflorum, liquorice and other components with the effects of relieving cough, eliminating phlegm, diminishing inflammation, easing pain and the like, and can directly act on the throat mucosa; and the ginseng, the astragalus membranaceus and other components with the effects of regulating immunity, tonifying middle-Jiao and Qi and the like can be quickly dissolved and then effectively absorbed.

To provide an alcoholic beverage that achieves reduction in stimulation from alcohol and / or an odd flavor of alcohol after drinking.SOLUTION: An alcoholic beverage includes cinnamaldehyde and / or terpinyl acetate.SELECTED DRAWING: None

The present disclosure relates to methods for treating subjects having a substance use disorder (SUD) with 4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 negative allosteric modulators. Specifically, in some embodiments, this disclosure relates to methods of treating a subject having SUD who is at risk of relapse to alcohol use. In some embodiments, this disclosure relates to methods of promoting remission in a subject having SUD. In some embodiments, the SUD is alcohol use disorder (AUD), opioid use disorder (OUD), or a stimulant use disorder such as cocaine use disorder (CUD).

The invention discloses an integrated device with rubber tapping and stimulant smearing functions. The integrated device comprises a magnetic attraction supporting guide rail, a circumferential sliding device, a lifting control device and a multifunctional execution device. The multifunctional execution device comprises a rubber tapping execution assembly and a brush head execution assembly, in the rising stroke, the rubber tapping execution assembly conducts rubber tapping operation, and meanwhile the brush head execution assembly conducts dry brushing pre-cleaning on the surface of a rubber tapping tree below a rubber tapping opening along with the movement track; in the descending stroke, the brush head execution assembly smears the stimulation liquid on the surface of the pre-cleaned rubber tapping tree, and meanwhile the rubber tapping execution assembly is reset; the rubber tapping execution assembly and the brush head execution assembly are installed in the same device, the rubber tapping function and the stimulation liquid smearing function are integrated in the same device, multiple purposes are achieved through one machine, the working efficiency is remarkably higher than that of manual work, the labor intensity is greatly reduced, precise delayed smearing after rubber tapping is achieved through program control, the stimulation effect is stable, and the application range is wide. The rubber yield can be improved.

The invention belongs to the technical field of cosmetic detection, and discloses a method and a kit for evaluating the stimulation degree of stimulants to eyes, the method comprises the following steps: (1) dividing zebrafish juvenile fishes which are normally hatched after fertilization into two groups, namely a control group and a sample group, the control group is zebrafish juvenile fishes which are not treated by stimulants, the sample group is zebrafish juvenile fishes which are not treated by stimulants, and the sample group is zebrafish juvenile fishes which are not treated by stimulants; the sample group is a treatment group containing to-be-evaluated irritants; and (2) a qPCR method is used for measuring the expression level of genes related to the stimulation degree of zebra fish eyes in each group, the eye stimulation degree of irritants is evaluated according to the expression condition of mRNA of the genes, grading is carried out, and the measured genes comprise three genes, namely kdrl, flt4 and tnf alpha. The invention designs a new method for evaluating the stimulation degree of the irritant to the eyes, and realizes rapid and accurate stimulation degree grading of the to-be-evaluated irritant.

The utility model discloses a snore-ceasing patch, which relates to the technical field of medical supplies and comprises a snore-ceasing patch body, a cutting groove is arranged at the top end of the snore-ceasing patch body, and an arc-shaped groove is arranged on one side of the cutting groove. A first plaster sheet is arranged at the top end of the snore stopping sheet body and fixedly connected to the top end of the snore stopping sheet body, a second plaster sheet is arranged at the bottom end of the snore stopping sheet body, and absorbent cotton is arranged on the inner side of the second plaster sheet. The first plaster sheet is arranged at the top end of the snore stopping sheet body, mild medicine is arranged on the inner side of the first plaster sheet, the sedation effect can be effectively improved after a patient inhales the medicine, the sleep quality is improved, the second plaster sheet is arranged at the bottom end of the snore stopping sheet body, the medicine cotton is arranged on the inner side of the second plaster sheet, and the snore stopping sheet is convenient to use. The refreshing agent is arranged in the pillow, so that the respiratory capacity in sleep can be effectively increased, the breathing quality is improved, and the sleep quality is effectively improved.

The invention is applicable to the technical field of biological medicine, and provides a self-assembled drug molecule and a preparation method and application thereof, and the preparation method comprises the following steps: synthesizing a compound Py-S-S-COOH; the method comprises the following steps: synthesizing a compound Py-S-S-B1RA; synthesizing a compound A; synthesizing a compound B; synthesizing a compound C; synthesizing a compound D; synthesizing a compound E; synthesizing a compound F; and the compound CBT-Gem-B1RA is synthesized through the synthesis of A chemotherapeutic drug gemcitabine and a targeted peptide bradykinin B1 receptor stimulant are coupled with a peptide fragment with self-assembly performance, so that the molecule has the capabilities of penetrating a blood brain barrier and targeting brain glioma, can smoothly enter a brain glioma part and can be self-assembled into nano particles in brain glioma cells, and the nano particles can be used for preparing a drug for treating brain glioma. The residence time of the drug in tumor cells is prolonged, the drug enrichment concentration is increased, and finally the glioma specific targeted therapy is realized.

Methods, devices, and systems are disclosed for controlled delivery of a therapy, such as a stimulant, to a mouth of a subject via an oral device positioned in a secured configuration in the mouth. At least one of a tongue position stimulator (TST) and tongue position sensor (TSE) is provided, according to certain aspects. According to another aspect, a stimulus is delivered to the mouth and / or tongue via a mouthpiece secured to the subject's teeth. In another regard, a stimulus is delivered that generates a natural response to eliminate or reduce sleep disorders, such as for example at least one of snoring and obstructive sleep apnea.

The invention provides a lipidoid Toll-like receptor agonist derivative as well as preparation and application thereof, and particularly provides a compound as shown in a formula I, a preparation method of the compound and application of the compound as a TLR7 and / or TLR8 agonist. The compounds can be used as immunostimulators and adjuvants.

The present invention relates to compounds of general formula (I), wherein the groups R1, R2 and n are defined as in claim 1, which are ghrelin O-acyl transferase (GOAT) inhibitors for use in the treatment of substance use disorder (SUD,) in particular for use in the treatment of opioid use disorder (OUD) or stimulant use disorder (StimUD), in patients with high impulsivity.

The present disclosure relates, in part, to flow cytometric methods for detecting or measuring the response of a subject to an exogenous stimulant, such as environmental, foodstuff, and medicament allergens.

Methods and compositions are disclosed for rapidly relieving symptoms in subjects with depressive, stressor and substance abuse conditions, e.g., major depression, treatment-resistant depression, post-partum depression, bipolar depression, post-traumatic stress disorder, substance use disorders, negative and cognitive symptoms of schizophrenia, as well as for slowing progression of mild cognitive impairment and dementia, using an intermittent dosing regimen of memantine or amantadine or a structural analogue or pharmaceutically acceptable salt of memantine or amantadine (optionally no more frequently than every 2 days) at a dose sufficient to activate Set A brain structures, in combination with a second drug at a dose which activates Set B brain structures but which does not appreciably evoke brain activity linked to hallucinogenic and other psychotomimetic perceptions. In some instances the second drug is either 1) a low dose psilocybin or low dose of other psychedelic and stimulant molecules capable of activating Set B of brain structures which is administered at a dose low enough such that it does not appreciably evoke brain activity linked to hallucinogenic and other psychotomimetic perceptions, or is 2) mianserin (S isomer, R isomer, or a racemate comprising both isomers or structural analog or pharmaceutically acceptable salt thereof) or another standard of care antidepressant capable of activating Set B brain structures, or 3) lumateperone or another antipsychotic capable of activating Set B brain structures.

The present disclosure provides at least one anxiolytic; and at least one stimulant; and a composition comprising: at least one anxiolytic; at least one stimulant; and a pharmaceutically acceptable carrier. Methods of treating a subject having a condition, such as a central nervous system disorder, comprising administering to the subject having a condition, at least one anxiolytic; and at least one stimulant, where the administering of the active ingredients, i.e., at least one anxiolytic and at least one stimulant, may occur together, separately, sequentially, and / or simultaneously. These active ingredients may be provided to a subject suffering from a condition in an amount sufficient to treat the condition in the subject in need thereof, where the treatment prevents, alleviates, reduces, eliminates, or interferes with at least one of the symptoms associated with the condition.

The invention relates to a pharmaceutical application of a GLP-1 receptor stimulant semeglutide, in particular to a novel pharmaceutical application of the GLP-1 receptor stimulant semeglutide, namely the semeglutide regulates hippocampal mitochondrial kinetics and mitochondrial autophagy balance by activating a phosphatidylinositol 3-kinase (PI3K) / protein kinase B (Akt) signal channel, so that the GLP-1 receptor stimulant semeglutide can be used for treating the hippocampal mitochondrial autophagy. The glial cell phenotype is regulated to be converted from a proinflammatory state to an anti-inflammatory state, and the cognitive impairment is improved. The invention determines a new medicine application method for linking the semeglutide with hippocampal pathology reduction and cognitive function recovery, and has important significance on treatment of VaD.

The objective is to provide a novel carbon dioxide stimulation enhancer. [Solution] N-(heptan-4-yl)benzo[d][1,3]dioxol-5-carboxamide is used as a carbonation stimulant enhancer. Furthermore, it is also possible to use spirantol or the like in combination.

In some embodiments, the present invention discloses a method for treating drug overdose, comprising administering a therapeutically effective amount of a respiratory stimulant to a patient in need, wherein the overdose drug comprises an α2-adrenergic receptor agonist.

The embodiment of the invention provides a water-based moistening atomized liquid and a preparation method thereof, the water-based moistening atomized liquid is applied to ultrasonic atomization, and the water-based moistening atomized liquid comprises the following components in parts by weight: 70-90 parts of deionized water; 5-20 parts of a humectant; 1-3 parts of a moistening agent; 0.1-0.2 part of a body fluid generating agent; 0.1 to 0.2 part of a pH buffer agent; wherein the moistening agent is prepared from at least one of trehalose, panthenol, sodium hyaluronate, erythritol, sorbitol and menthol. According to the water-based moistening-enhancing atomized liquid and the preparation method thereof provided by the embodiment of the invention, by optimizing the viscosity and selecting the functional components, the efficient, stable and lasting atomization process is realized. The atomization sheet is not easy to block, and the service life is prolonged; the generated aerosol liquid drops are fine and uniform, the coalescence tendency is low in the conveying process, the condensation liquid accumulation phenomenon is effectively inhibited, and the use reliability of the product and the user experience are improved.

The invention discloses an application of a prostaglandin EP4 receptor stimulant in a preparation for preventing or treating thyroid-associated ophthalmopathy, belongs to the technical field of biological medicines, and aims to find a new and completely effective preparation for locally inhibiting orbit fat hyperplasia. The 3D cell culture technology closer to the in-vivo environment is used for exploring the influence of the prostaglandin EP4 receptor agonist L-902688 on adipogenic differentiation of TAO patient eye socket adipose-derived mesenchymal stem cells (OASCs), and the result shows that the L-902688 can significantly promote brown adipose differentiation and increase lipid hydrolysis and consumption, can effectively reduce fat accumulation and does not promote secretion of inflammatory factors. The results provide a new treatment thought for clinical treatment of TAO.

The invention relates to a nasal administration composition containing a GLP-1 receptor stimulant and a preparation method and application thereof. In-vivo and in-vitro tests show that the composition has good stability, good bioavailability is achieved after nasal administration of rats, and little drug is distributed in brain tissue.