96 results about "Vascular health" patented technology

Method and calculations determine an individual's, or several individuals' simultaneous rates of oxygen consumption, maximum rates of oxygen consumption, heart rates, calorie expenditures, and METS (multiples of metabolic resting rate) in order to determine the amounts of work that is performed by the individual's body. A heart monitor measures the heart rate, and an accelerometer measures the acceleration of the body along one or more axes. An altimeter measures change in altitude, a glucose monitor measures glucose in tissue and blood, and thermometers, thermistors, or thermocouples measure body temperature. Data including body fat and blood pressure measurements are stored locally and transferred to a processor for calculation of the rate of physiological energy expenditure. Certain cardiovascular parameters are mathematically determined. Comparison of each axis response to the individual's moment can be used to identify the type of activity performed and the information may be used to accurately calculate total energy expenditure for each physical activity. Energy expenditure may be calculated by assigning a separate proportionality coefficient to each axis and tabulating the resulting filtered dynamic acceleration over time, or by comparison with previously predetermined expenditures for each activity type. A comparison of total energy expenditure from the current activity is compared with expenditure from a previous activity, or with a baseline expenditure rate to assess the level of current expenditure. A measure of the individual's cardio-vascular health may be obtained by monitoring the heart's responses to various types of activity and to total energy expended.

The present invention provides methods and apparatus for assessing a patient's vascular health including endothelial function by monitoring changes in hemodynamic parameters responsive to the introduction of a vasostimulant. The invention provides a thermal energy measurement apparatus including a thermal energy sensor adapted to measure temperature of a body part while not substantially changing the temperature of the body part, and a display or recorder coupled to the thermal energy sensor, wherein the thermal energy sensor measures the temperature of the body part before and subsequent to the provision of a vasostimulant, and the display or recorder reports the temperature of the body part prior to the provision of the stimulant and the temperature of the body part after provision of the stimulant. Also provides are methods and apparatus providing for a second thermal energy sensor on a corresponding contralateral site to the site subject to the vasostimulant and simultaneously monitoring and recording of temperature of the contralateral site as a measure of neurovascular status and microvascular reactivity.

The invention relates to systems and methods for assessing blood flow in single or multiple vessels and segments, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for effect, for assessing risk factors, for evaluating intracranial pressure and for analyzing the results in a defined manner. The invention enables direct monitoring of therapies, substances and devices on blood vessels, especially those of the cerebral vasculature. Relevant blood flow parameters include mean flow velocity, systolic acceleration, and pulsatility index. Measurement and analysis of these parameters, and others, provides details regarding the vascular health of individual and multiple vessels and a global analysis of an individual's overall vascular health. The invention is applicable as both a system and method for monitoring and improving the design, performance, marketing and use of vascular stents. In particular, the invention enables DVA-assisted stenting procedures, including both pre-operative and post-operative management.

A guidewire with a sensor which can detect NO and/or superoxide levels is disclosed. This invention can be useful for in vivo analysis of vascular health.

The invention defines interdependent biofactors and biomolecules, and clinically useful formulations that are comprised of them. The active agents are demonstrated to be complementary in their physiologic functions especially as these relate to the quenching of free radicals and to the support of endothelial physiology, the reduction of hyperinsulinemia and improvements in vascular health. The active components of the invention are selected for inclusion in precise combinations specifically because they improve these various conditions and physiological functions, and by so doing reduce a variety of risks associated with hearing loss and tinnitus. The resulting enhancement of general systemic vascular health, improvement in local VIIIth nerve vascular health, modulation of conditions surrounding blood fluid dynamics, the consequences of hyperinsulinemia, and improvements in free radical defenses, all reduce the potential for cochlear hair cell death and VIIIth nerve atrophy, and the hearing loss and possible deafness that accompany them.

Methods for treating vascular disease in humans and generating data representing treatment plans are disclosed. A first set of clinical vascular health data from a healthcare provider and representing a vascular health condition of a patient is received at a data center server that is communicatively coupled to a public data network. One or more vascular disease analysis algorithms are applied to the first set of vascular health data, to result in creating and storing an initial treatment plan for the patient. A second set of vascular health data is received from a monitoring device that is associated with the patient and that is communicatively coupled to the data network; the second set of data include Doppler monitor data obtained from the peripheral vascular system of the patient. One or more vascular analysis algorithms are applied to result in creating one or more supplementary treatment plans for the patient. At least one of the treatment plans includes a biofeedback interaction. The treatment plans are provided to the patient over the data network. The foregoing steps are iteratively repeated one or more times as determined by the physician and patient, resulting in improved vascular health.

The invention relates to systems and methods for assessing blood flow in single or multiple vessels and segments, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for effect, for assessing risk factors, for evaluating intracranial pressure and for analyzing the results in a defined manner. The invention enables direct monitoring of therapies, substances and devices on blood vessels, especially those of the cerebral vasculature. Relevant blood flow parameters include mean flow velocity, systolic acceleration, and pulsatility index. Measurement and analysis of these parameters, and others, provides details regarding the vascular health of individual and multiple vessels and a global analysis of an individual's overall vascular health. The invention can track the onset, progression and treatment efficacy in an individual experiencing increased intracranial pressure, or can help identify underlying vulnerabilities of the vascular system to normal pressures, associated with and manifested as hydrocphalus or dementia.

A system and method of non-invasive or minimally invasive evaluating the cardiovascular system parameters to estimate the cardiac output and circulating blood volume of a patient undergoing hemodialysis. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health before and during hemodialysis.

A mobile measurement device comprising a computing device; one or more sensors that are coupled to the computing device using one or more corresponding compatible digital interfaces; and logic encoded with instructions which when executed perform determining and storing vascular function information and one or more of: values of metrics or parameters; physiological analysis of the parameters and the vascular function information; recommendations for actions that an individual or healthcare provider should take in response to the recommendations or parameters. Embodiments further include processes for using vascular function information collected from a mobile measurement device to generate the parameters, analysis, and recommendations.

Probiotic compositions, particularly oral compositions, comprising one or more bacteria that are capable of producing nitrite and/or nitric oxide in a subject are provided. Some compositions further comprise nitrate/nitrate, such as a botanical source of nitrate. Some compositions further comprise botanical sources of nitrate reductase. Also, provided are methods of improving the oral and/or vascular health of a subject by orally administering a composition comprising one or more bacteria capable of producing nitric oxide. Methods of repopulating the nitric oxide producing microflora and bacterial environment in the oral cavity of a subject are also provided.

The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined matter. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. In one of many embodiments, the present invention further provides an expert system for achieving the above.

In an embodiment, a data processing method comprises receiving, from a portable physiological measuring device configured for temporary attachment to a human body, data representing one or more physiological metrics or parameters of the body; receiving, from one or more Doppler vascular sensors configured for temporary attachment to peripheral artery locations of the body and a portable Doppler vascular signal measuring device coupled to the Doppler vascular sensors, vascular function information for the body; determining medical condition data indicating one or more medical conditions of the patient based on analysis and correlations of the vascular function information and the patient physiological metrics; generating and providing output records specifying one or more of: recommendations for actions that an individual or healthcare provider should take in response to the recommendations or parameters; or one or more reports, animations or figures; wherein the method is performed by one or more computing devices.

A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection and calibration methods are disclosed. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, cardiac index, blood volume and other indicators of cardiovascular health.

A method for digital thermal monitoring assessment of vascular function comprising a temporary arterial occlusion using a pneumatic cuff positioned on a subject's upper limb, monitoring skin temperature at the fingertip of the occluded limb for a period of time before, during, and after the occlusion, calculating a Zero Reactivity Curve based on variables including start temperature, room temperature, and the slope of temperature decline during the occlusion, and assessing vascular function based on comparing the Zero Reactivity Curve and the observed temperature rebound after the occlusion is removed. A vascular reactivity monitoring apparatus for measuring skin surface temperature comprising an inflatable cuff for placement around a subject's limb, a digital thermal measuring device and photoplethysmography measuring device for placement on a finger of the subject's limb wearing the cuff and a second digital monitoring device and photoplethysmography measuring device for placement on a finger of the subject's contralateral limb.

A system (1) for computing a disease risk score of a patient based on a recommendation of treatment or lifestyle changes is disclosed. The system comprises an input device (11) for receiving risk parameter values for computing the disease risk score according to a risk score algorithm, and for receiving the recommendation of treatment or lifestyle changes, an interpreter (21) for computing at least one risk parameter value for computing the disease risk score, on the basis of the recommended treatment or lifestyle changes, a risk calculator (31) for calculating the disease risk score on the basis of the received risk parameter values and the computed risk parameter value, and an output device (41) for communicating the calculated disease risk score. Thanks to the interpreter (21), the recommended treatment or lifestyle change is “translated” into a value of a risk parameter for computing the disease risk score, there by allowing calculating the risk score resulting from the treatment or lifestyle change.

The invention relates to diagnostic and therapeutic tools and applications, particularly useful in diseases that affect vascular health and in inflammatory diseases. In particular, said diagnostic and therapeutic tools employ suitable detection or modulation of endothelial glycocalyx.

This document describes the assessment of human physiological systems in a manner that can be applied throughout the population. Various noninvasive sensors (including wearable, passive contact and noncontact sensors) may be integrated into the furniture of a person's home (including a mat, a toilet-seat, a mirror and a bathtub). They can be used to detect vitals and other parameters and combined with mathematical models to assess the functional state of physiological systems. For example, the health of the cardiovascular system is ultimately determined by organ blood perfusion and molecular gas exchange. In lieu of measuring these functional metrics directly, noninvasive sensors are used to monitor cardiac pressures and volumes, along with pressure transit through the vascular to quantify cardiovascular health, presenting little if any risk to the person and are simple and easy to use. In particular, cardiac pressure-volume loops are determined at different points in time and a health trend for the physiological system is determined based thereon.

The invention belongs to the technical field of medical apparatus and instruments, and in particular relates to a handheld angiocarpy health monitoring device. The handheld angiocarpy health monitoring device comprises a shell and a physiological information collecting device mounted on the shell, wherein the physiological information collecting device comprises an electrocardio collecting assembly, the electrocardio collecting assembly comprises electrodes and leads connected with the electrodes, the electrodes comprise upper limb conduction electrodes, chest conduction electrodes, left oxter conduction electrodes and lower limb conduction electrodes, the shell comprises a handheld piece, an upper limb conduction electrode fixing piece and a left oxter conduction electrode fixing piece, and the upper limb conduction electrode fixing piece and/or the left oxter conduction electrode fixing piece are/is movably connected to the handheld piece by virtue of a transmission assembly. According to the handheld angiocarpy health monitoring device, ten detection potentials are organically integrated, the handheld angiocarpy health monitoring device is held by a hand, placed on the thorax and abdomen, and pressed, the electrodes completely and accurately attach to the human potential points, and thus the requirement for monitoring the health of the angiocarpy is satisfied.