42 results about "Glycocalyx" patented technology

Disclosed are methods and compositions for the treatment of a variety of disorders in subjects by affecting the glycocalyx of a subject in need of such treatment. The methods comprise administering to a subject an effective amount of a sulfated polysaccharide (SP) or analogue thereof, the SP being a non-animal based (e.g., plant, or bacteria derived) sulfated polysaccharide. The SPs can be administered as single agents, or in combination with one another, or with other medications to promote efficacy. Pharmaceutical compositions and comestibles including such SPs are also described.

A new indication of vitamin K is disclosed which results in the provision of methods of treatment, both therapeutic and non-therapeutic, as well as functional foods and pharmaceutical and nutraceutical products comprising vitamin K for improving microvascular integrity and capillary structure and function, thus preventing, mitigating, counteracting or curing diseases associated with impaired capillary morphology including the glycocalyx or capillary dysfunction. Preferably, vitamin K is a menaquinone, most preferably selected from the long-chain menaquinones MK-7 through MK-10.

The present invention relates to a substantially planar substrate for use in patch clamp analysis of the electrophysiological properties of a cell membrane comprising a glycocalyx, wherein the substrate comprises an aperture having a rim, the rim being adapted to form a gigaseal upon contact with the cell membrane. The invention further provides a method of making such a substrate and method for analysing the electrophysiological properties of a cell membrane comprising a glycocalyx.

A scientific computer system with processor capable of recording, storing and reprogramming the natural electrical signals of cancer cells as found in tumors of humans and animals. The reprogramming process is designed to create a confounding electrical signal for retransmission into a malignant tumor to damage or shut-down the cellular internal electrical communication system. Altering the electrical charge on the glycocalyx of the outer cell membrane is also part of the treatment by application of ions. The invention causes cancer cell death as a medical treatment using ultra-low voltage and amperage encoded signals which are reprogrammed from cancer cell communication signals.

The present invention relates to a substantially planar substrate for use in patch clamp analysis of the electrophysiological properties of a cell membrane comprising a glycocalyx, wherein the substrate comprises an aperture having a rim, the rim being adapted to form a gigaseal upon contact with the cell membrane, The invention further provides a method of making such a substrate and method for analysing the electrophysiological properties of a cell membrane comprising a glycocalyx.

Disclosed are methods and compositions for the treatment of a variety of disorders in subjects by affecting the glycocalyx of a subject in need of such treatment. The methods comprise administering to a subject an effective amount of a sulfated polysaccharide (SP) or analogue thereof, the SP being a non-animal based (e.g., plant, or bacteria derived) sulfated polysaccharide. The SPs can be administered as single agents, or in combination with one another, or with other medications to promote efficacy. Pharmaceutical compositions and comestibles including such SPs are also described.

A bioadhesive composition for bonding together adjacent surfaces of wood comprises a microbially-produced fermentation residue containing adherent microbial cells and glycocalyx. This residue finds particular application as a replacement for a significant amount of phenol-formaldehyde (PF) or other conventional adhesive component commonly used in the production of plywood and other wood products.

Disclosed is a medicament for treating AIDS, wherein the active constituents include Fucoidan-Glycocalyx polymeric compound, which is a protein polysaccharide containing sulfate groups extracted from Chinese herbal sea apron. The preparing process consists of steps of choosing materials, soaking and cleaning, disintegrating, water extracting, low concentration alcohol depositing, high concentration depositing, purifying to obtain the end product.

The invention provides an application of neferine in the prevention or treatment of acute respiratory distress syndrome (ARDS). The neferine is alkaloid extracted from natural plants and has antioxidant activity. Based on the construction of animal and cell damage models of acute respiratory distress syndrome, by HE, Evan blue staining, fluorescent probe, immunofluorescence labeling and the like, it is verified that the neferine can reduce the production and release of reactive oxygen species (ROS) and reduce the degradation of vascular endothelium polysaccharide coating (Glycocalyx), thus the occurrence and development of ARDS are inhibited, and ARDS is prevented or treated.

The invention relates to a willow needle mushroom glycocalyx, as well as a preparation method and application thereof, and belongs to the field of natural medicine development. The preparation method comprises the following steps: inoculating willow needle mushroom seeds into a culture medium, wherein the culture conditions such as temperature, rotational speed and time are 22 to 26 DEG C, 120 to 160 r/min, and 5 to 6 days respectively; inoculating 10 to 20 percent inoculum concentration of the willow needle mushroom seeds into a fermentation culture medium, wherein the fermentation conditions such as temperature, rotational speed and time are 22 to 26 DEG C, 120 to 160 r/min, and 5 to 6 days respectively; carrying out centrifugation to collect a supernatant at the rotational speed of 4000 r/min to 6000 r/min; carrying out rotary evaporation and concentration till the volume is 1/10 to 1/8 of the original volume; adding anhydrous ethanol of which the volume is 3 to 5 times of the concentrated liquid at the temperature of 4 DEG C for 12 to 16 hours' precipitation; carrying out 10 to 20 minutes' centrifugation, wherein the rotational speed is 3000 to 5000 r/min; collecting the precipitate; drying the precipitate at 45 to 50 DEG C. The willow needle mushroom glycocalyx fills up the blank of resource development and utilization of willow needle mushroom in the market. Moreover, an important foundation for deep development of polysaccharide immunological accelerator medicine and health foods with immunomodulatory effects is provided, and the economic value and the marketable value are high.

A composition for treating multiple disease causes including a glycocalyx restoring and maintaining compound in an oral dosage form. A method of treating cardiovascular disease (CVD), by administering a glycocalyx restoring and maintaining compound to an individual suffering from CVD, restoring the glycocalyx, reversing inflammation, and reversing oxidative damage.

The invention relates to application of anisodamine or a pharmaceutically acceptable salt thereof in preparation of a cell glycocalyx protective agent, in particular to application of the anisodamineor the pharmaceutically acceptable salt thereof serving as the cell glycocalyx protective agent in recovery and protection of cell glycocalyx and cell adhesion. The application of the anisodamine or the pharmaceutically acceptable salt thereof in preparation of the cell glycocalyx protective agent also has the effect of protecting endothelial cell structures and functions.

This invention relates to a medicine for chronic renal failure and its preparation method, and belongs to the technology field of preparing medicine for treating chronic renal failure. The medicine is characterized in comprising the active constituent of F-Glycocalyx which is the valid target of ecklonia kurome and is protein polysaccharides containing sulfate group extracted from ecklonia kurome. the preparation method of F-Glycocalyx comprise (1) selecting, (2) soaking and cleaning, (3) pulverizing, (4) extracting with water, (5) precipitating with alcohol of low concentration, (6)precipitating with alcohol of high concentration, and (7) purifying to obtain purified product, drying, and packaging. The inventive medicine can effectively inhibit malignant tumor viral, improve immunity with no toxicity and adverse side effect, no untoward reaction and low cost.

Provided herein are selectin-binding peptide ligands having both D- and L-amino acids, and peptide conjugates including the provided peptide ligands. The peptide conjugates can include a biopolymer backbone, such as dermatan sulfate, and 33 or fewer peptide ligands conjugated to the biopolymer. Also provided are methods for using the provided peptide conjugates to treat patients suffering from endothelial dysfunction.

SCGB-based preparations and methods to use these preparations to protect the glycocalyx in medical, veterinary, and cosmetic applications are provided. The secretoglobins (SCGBs) are a family of small secreted globular proteins present in all mammals and sharing conserved structure and thought to share similar immunomodulatory functions. Heparan sulfate proteoglycan proteins (HSPGs) are expressed on the outer membranes of cells and have carbohydrate side chains that, together, make up the glycocalyx. The glycocalyx is a protective layer surrounding all cells, acting as a filter regulating the passage of nutrients into the cell and modifying cell signaling by external factors. There are two major families of HSPGs including syndecans and glypicans, plus several other HSPGs in all mammals. SCGBs bind to, and interact with, HSPGs to further modulate cell signaling and cellular responses to external factors.