461 results about "Barrier function" patented technology

Therapeutic methods and compositions useful for the prevention and/or treatment of cellular membrane damage leading to or resulting from peroxidation of the cellular membrane and a breakdown of the barrier function of the cellular membrane. A therapeutic composition includes a combination of a membrane sealing sealing surfactant and a cofactor treatment consisting of an antioxidant and a cellular energy store. To affect this goal, the permeability of damaged cellular membranes is reestablished by the membrane sealing surfactant, effectively “sealing” the injured membranes. To facilitate rapid tissue recovery, cellular energy levels can be reestablished through addition of a cellular energy source such as, for example, MgCl₂-ATP which, serves a further dual benefit of improving the cellular ion balance. Addition of an antioxidant eliminates the generation of Reactive Oxygen intermediates and enhances the metabolism of free radicals.

Pharmaceutical tablet, capable of delivering the active substance or the active substances, according to a predeterminable release profile, comprising a core with an external partial coating in which said core consists of 3 layers, wherein the upper layer contains an amount of the active substance with suitable excipients, the intermediate layer consists of polymeric material with retarding barrier function and the lower layer contains the remaining amount of the active substance with suitable excipients and said external coating consists of controlled permeability polymeric materials, applied by compression to the lower surface and to the lateral surface of the core.

Systems and methods apply a selected treatment agent or agents into contact with tissue at or in the region of a dysfunctional sphincter (in the case of GERD, fecal incontinence, or other dysfunctional sphincter disorders) to affect improved sphincter barrier function and/or to disrupt abnormal nerve pathways. The treatment agent can include at least one cytokine and/or at least one tissue bulking agent and/or at least one vanilloid compound to evoke a desired tissue response. The systems and methods can be used a primary treatment modality, or applied as a supplementary treatment before, during or after a primary intervention.

The invention features a method of treating at least one sign of aging on the skin selected from the group consisting of (i) thickening the skin, (ii) enhancing the barrier function of skin, and/or (iii) treating at least one sign of aging on the skin selected from the group consisting of enhancing the elasticity of said skin, enhancing the firmness of said skin, smoothing the surface of the skin, and reducing the appearance of wrinkles on the skin, wherein the method includes applying to skin in need of such treatment a skin care composition including a tensioning polymer, wherein the tensioning polymer has a contractile force greater than about 3 g/mg and a water resistance index from about 0.9 to about 1.9.

The present invention pertains to a composition for inducing a pattern of gut barrier maturation similar to that observed with breast-feeding and able to improve gut barrier maturation, e.g. during neonatal stress. In particular, the present invention relates to an infant formula containing a combination of specific ingredients designed to provide a synergistic effect all along gastrointestinal tract and barrier function.

Cosmetic or dermopharmaceutical compositions containing Pseudoalteromonas ferment extract for the treatment and/or care of the skin, scalp and/or nails, preferably to improve the barrier function of the skin, scalp and/or nails, and specifically for the treatment and/or care of those conditions, disorders and/or pathologies of the skin, scalp and/or nails associated with an alteration in the keratinization process.

The invention is related to compositions which can be used as dermal formulations for supporting the skin to restore normal conditions in case of e.g. irritated skin, or to support medical therapy of skin with atopic dermatitis symptoms, atopic dermatitis, psoriasis or related diseases (e.g. accompanied by distorted barrier function of the skin and microbial load). The compositions of the invention can be used for dermo-cosmetic products but also for pharmaceutical/-medical products, depending on the composition and the additional actives incorporated (cosmetic actives or drugs). The invention is based on the synergistic effect of metallic particles, in particular silver particles (such as microsilver, nanosilver) and lipid particles (lipid nanoparticles or lipid microparticles). As alternatives to silver particles, other metallic particles (e.g. zinc, copper) or nanocrystalline actives can be incorporated (e.g. replacing the anti-oxidative silver by anti-oxidative nanocrystals of plant molecules such as hesperitin). This leads to combinations of lipid particles with nanocrystals for dermal use.

Skin conditioning compositions comprising a C4 to C30 monoalkyl-, dialkyl, monoalkanoyl- or dialkanoyl-substituted isohexide are found to exhibit a marked effect on skin hydration and barrier function homeostasis thereby improving skin appearances.

A method for depositing a film is provided. In the method, an object to be processed is accommodated in a process chamber, and an insulating film made of a polymer thin film is deposited on a surface of the object to be processed by supplying a first source gas composed of an acid anhydride and a second source gas composed of a diamine into the process chamber that is evacuated. Next, the insulating film is modified so as to have a barrier function by stopping the supply of the second source gas into the process chamber and continuously supplying the first source gas into the process chamber.

The present invention is directed to an absorbent article having a backsheet, an absorbent core and cuffs and/or a topsheet, the topsheet being provided with at least one opening adapted to receive fecal material, the cuffs or topsheet comprising a nonwoven sheet material, comprising typically at least two nonwoven layers, the layers being typically only partially attached to one another and each comprising typically two or more nonwoven webs that are laminated together, whereof the skin-contacting nonwoven layer or web has a specific low bending rigidity, whilst the nonwoven sheet as a whole has a very high barrier function.

The present invention relates to a composition used as a vehicle for percutaneous absorption of Pharmaceutical and Cosmaceutical active agents that comprises Dimethiconol (hydroxyl-terminated polydimethydimethylsiloxane), dimethicone-350 (polydimethylsiloxane-350), cyclomethicone-5 nf (decamethylcyclopentasiloxane), alkymeth siloxane copolyol-lauryl peg/ppg 18/18 methicone (alkymethyl siloxane copolyol), cyclopentasiloxane and dimethicone Crosspolymer (silicone elastomer and decamethylcyclopentasiloxane), stearoxytrimethylsilane and stearyl alcohol (silicone wax), and deionized water. This composition serves several key applications: (1) it is a vehicle for percutaneous absorption of Pharmaceutical and Cosmaceutical active agents; (2) it acts as a method for utilizing other compositions in the treatment of inflammatory conditions of the skin including, but by no means limited to, atopic dermatitis (eczema), allergic contact dermatitis, seborrheic dermatitits, psoriasis, xerosis and atopia; (3) it is a treatment of inflammatory conditions of mucosae; (4) it relates to other compositions and methods for protecting and enhancing the barrier function of the skin.

A system commands a movable barrier operator to control movement of a movable barrier and perform additional movable barrier functions. An identification transmitter wirelessly transmits an identification signal, where the identification signal comprises a code. A primary transmitter stores at least one vehicle identification code corresponding to a specific vehicle and receives a request to transmit a wireless control signal to the movable barrier operator to command the movable barrier operator to perform the at least one of the additional movable barrier functions. The primary transmitter also transmits the wireless control signal in response to receiving the request, detecting the identification signal, and determining that the code of the identification signal matches the at least one vehicle identification code.

The invention discloses a high-rise curtain wall cleaning robot and a high-rise curtain wall cleaning method and belongs to the field of wall-climbing robots. The high-rise curtain wall cleaning robot and the high-rise curtain wall cleaning method have the advantages that horizontal and longitudinal movement of the entire cleaning robot is realized by the aid of alternative adsorption of an external adsorption walking mechanism and an internal adsorption walking mechanism on a curtain wall, the curtain wall cleaning robot can rotate freely through rotational movement of the internal adsorption walking mechanism, 360-degree omnidirectional movement is realized, and non-dead angle cleaning of specially-shaped curtain walls can be realized; meanwhile, sucking disks in the external adsorption walking mechanism and the internal adsorption walking mechanism are telescopic, a good barrier function of the curtain wall cleaning robot is achieved, and the curtain wall cleaning robot is applicable to cleaning of medium and high-level frameless glass curtain walls and framed glass curtain walls; a cleaning mechanism can be lifted or depressed to be better attached to the surface of the curtain walls, the optimum cleaning effect is achieved, and after the cleaning mechanism is uplifted, the curtain wall cleaning robot can walk and cross obstacles on the curtain walls flexibly.

The invention relates to a longitudinal-transverse-vertical force cooperative control method of a distributed electrically driven vehicle. The method is implemented by a vehicle control system: 1) formulation of expected resultant force and moment; 2) optimal distribution of longitudinal, transverse and vertical forces of four wheels; 3) specific execution of the forces. The expected values of the resultant force and the moment of the whole vehicle are obtained by utilizing various information of the vehicle, an integrated tyre force optimization problem is formed by establishing a constraint condition and an objective function, and an optimization solution algorithm is designed for the problem, wherein the optimization algorithm comprises a constraint optimization method which adopts a barrier function method and a Newton method, and a feasible region planning method based on vehicle state continuity. The method does not need to implement different control strategies according to different work conditions of tyres, realizes unified optimal distribution and control of the longitudinal, transverse and vertical forces of the tyres, comprehensively improves the operation stability and the driving posture of the vehicle, and can be applied to driverless operation of vehicles in the future.

The present invention relates to devices, systems and methods for measuring cell barrier function. In particular, the present invention relates to microfluidic devices for use in in vitro models of the blood-brain barrier and modeling the transport across this barrier.

The present invention provides an establishment and characterization method of in-vitro blood brain barrier model based on microfluidic chip. The microfluidic chip mainly comprises a cell inlet pool (1), collagen inlet pools (2), a cell culture chamber (3) and a waste liquid pool (4). The upper of the cell culture chamber (3) is connected with the cell inlet pool (1). The lower of the cell culture chamber (3) is connected with the waste liquid pool (4). Each collagen inlet pool respectively includes four observation chambers. The collagen inlet pools are communicated with the cell culture chamber (3). According to the invention, construction and characterization of the in-vitro blood brain barrier model and evaluation of the barrier function are integrated into a chip of a few square centimeters, and the chip can be used for in-vitro simulation and subsequent applications of the blood-brain barrier model. Compared the present invention with a Transwell small chamber co-culture model, the cell co-culture model secondary vaccination and time-consuming problems are solved, the flow conditions are added, the chip is closer to the true in-vivo microenvironment, the cell and reagent consumption are significantly reduced, and a plurality of experiment parameters can be obtained once and simultaneously.

The invention discloses a boron-modified organic silicon resin high-temperature-resistant coating which comprises the following components in percentage by mass: 45%-58% of boron-modified organic silicon resin, 35%-45% of heat-resisting pigment fillers and 2%-4% of auxiliary agents, wherein the boron-modified organic silicon resin is boric-acid-modified organic silicon resin or epoxy-modified silicon-boron resin; and the mass ratio of nanometer silicon dioxide to barrier function fillers to aluminum powder which are contained in the heat-resisting pigment fillers is 1.5:1:1. The invention also discloses a preparation method of the boron-modified organic silicon resin high-temperature-resistant coating. The preparation method disclosed by the invention can be implemented on an existing coating preparation production line without increasing equipment investment; the prepared high temperature-resistant organic silicon coating can be coated by adopting a spray coating process and constructed by adopting a roll coating process, can be subjected to high temperature of 800 DEG C for a long time and has corrosion-resistant property.

The invention discloses a method for preparing potassium hexatitanate whisker composite SiO2 aerogel thermal insulation material, which comprises the steps of adopting a potassium hexatitanate whisker as a reinforcing phase, utilizing a coupling agent for the surface modification of the potassium hexatitanate whisker, preparing a SiO2 gel precursor at the same time, mixing and stirring the modified potassium hexatitanate whisker and the SiO2 gel precursor, keeping stand to gelatinate, aging to obtain SiO2 gel containing the potassium hexatitanate whisker, then performing supercritical drying and heat treatment through a high pressure kettle, and obtaining the potassium hexatitanate whisker composite SiO2 aerogel thermal insulation material. The composite thermal insulation material has good barrier function on solid heat transfer and air convection heat transfer, can effectively block infrared radiation heat transfer at the same time, has heat conductivity coefficient of between 0.01 and 0.015w/m.k at normal temperature, and improves 3 to 5 times of strength than SiO2 aerogel. The method has wide application range, and can meet operating requirements of more harsh thermal protection conditions of aviation, spaceflight, military affairs and civil use.

The invention relates to a plant active component composition with slow anti-allergic action. The plant active component composition is mainly prepared from natural plant active components: 0.1-5wt% of glycyrrhetinic acid, 0.05-1wt% of apigenin, 0.05-1% of table gallic catechin gallic acid ester, 0.1-3wt% of asiaticoside, 0.1-5wt% of baicalin and 0.1-10wt% of fucus serratus extract. The composition is used for preparing cosmetics or personal care products with a plurality of effects of resisting skin allergy, diminishing inflammation, relieving itching, resisting oxidation, moisturizing and the like. The composition is safe and free of toxic and side effects, and can be compounded with a plurality of components, sensitive skin and dry skin are effectively improved, and the barrier function of the skin is reinforced.

The invention discloses an epitaxial wafer, growing method and LED structure of an Mg-doped electronic barrier layer. The epitaxial wafer comprises a substrate, a low-temperature GaN buffer layer, a high-temperature GaN buffer layer, an n type GaN layer, an n type AlGaN layer, an n type contact layer, a multiple quantum well layer and a GaN base layer from bottom to top in sequence. An AlGaN/GaN electronic barrier layer is arranged on the GaN base layer, a low-temperature P type GaN layer is arranged on the AlGaN/GaN electronic barrier layer, a high-concentration AlGaN/InGaN electronic barrier layer doped with Mg is arranged on the low-temperature P type GaN layer, a high-temperature P type GaN layer is arranged on the AlGaN/InGaN electronic barrier layer, and a P type contact layer is arranged on the high-temperature P type GaN layer. The epitaxial wafer, growing method and LED structure of the Mg-doped electronic barrier layer have the advantages that the hole concentration of the part injected into multiple quantum wells of a P layer is improved, and the barrier function of electrons is improved so that the luminous efficiency can be improved, and the brightness can be obviously improved.

The subject of the invention is the use of at least one compound chosen from β-endorphin and β-endorphin-mimetic agents on the keratinocytes of the skin, for example in a cosmetic composition to enhance the barrier function of the skin, enhance its resistance to stress and in particular to pollution. It also relates to a method of cosmetic treatment for enhancing the barrier function and/or the moisturization of the skin and/or mucous membranes.

The invention relates to the use of a composition containing, preferably in a physiologically acceptable medium comprising an aqueous phase, at least one oxidation-sensitive hydrophilic active principle selected from the group consisting of ascorbic acid and its derivatives and at least one non-crosslinked N-vinylimidazole polymer or copolymer, the active principle and the polymer or copolymer both being present in the aqueous phase, for promoting the synthesis of epidermal ceramides and/or for improving the barrier function of the skin, among other uses.

The invention discloses a whitening composition and cream thereof. The whitening cream contains a whitening composition which is prepared from nicotinamide, arbutin, citrus peel extractives, tea extractives, scutellaria root extractives, cucumber extractives, apple extractives and the like, wherein the nicotinamide can enhance the skin barrier function, and has the effects of whitening the skin and resisting aging and acnes; the arbutin can inhibit activity of tyrosinase to achieve the whitening effect, and can protect the skin against free radical damage; the citrus peel extractives can enhance the skin brightness, lower percutaneous water loss and enhance the skin moisturizing and barrier functions; due to the synergistic effect of the tea extractives, the scutellaria root extractives, the cucumber extractives and the apple extractives, the effects of whitening, skin tendering and moisturizing are enhanced; the whitening composition is used in whitening skin care products such as a whitening cream product, dark skin and primary spots on the skin can be remarkably improved, the deposited stains and coloring matter accumulated over a long period can be faded and relieved, and the whitening effect is obvious.

The present invention describes tunable methods of treating cellulosic materials with a composition that provides increased hydrophobicity and/or lipophobicity to such materials without sacrificing the biodegradability thereof. The methods as disclosed provide for binding of saccharide fatty acid esters on cellulosic materials, including that the disclosure provides products made by such methods. The materials thus treated display higher hydrophobicity, lipophobicity, barrier function, and mechanical properties, and may be used in any application where such features are desired.

The invention discloses a method for preparing a bionic modified collagen tissue repair material. In the preparation method, the tissue repair material is prepared from type I collagen serving as a raw material, is formed by the processes of freeze-drying, pressing, coating, cross-linking, drying and the like and has a bionic structure, namely the structure of a compact layer and a loose layer is in graded distribution and does not have any obvious interface layer. The bionic modified collagen tissue repair material does not contain any chemical components, has high biocompatibility and can be completely absorbed by organisms, wherein the compact layer has barrier function and can effectively prevent cells at the periphery of defective tissues from growing into a damaged tissue area; and the loose layer can guide the adhesion and proliferation of the cells of the defective tissues so as to fulfill the aim of tissue repair.