A cosmetic
system for sustained dermal delivery, characterized in that it comprises: • a first component (10) in a
solid state, comprising an
anhydrous lipid-based matrix and at least one bioactive agent, in particular a
polynucleotide (PDRN), provided as surface-treated or encapsulated particles; • a second component (20) in a
liquid state, comprising an aqueous activator mist (21) containing a non-ionic
surfactant system and at least one penetration accelerator;• wherein the first component (10) is configured such that, upon contact with the activator mist (21), it undergoes an in-situ
phase inversion from a
solid lipid state, appearing as a
solid track (11), to a resulting liquid serum state (12), characterized by a reduction in interfacial tension, which generates a capillary wicking effect for dermal delivery into
skin microstructures (31) without the use of fibrous carrier substrates.