8results about How to "Improve oral bioavailability" patented technology

This invention discloses a chitosan-Chlamydomonas reinhardtii protein composite carrier, its preparation method, and its application. The composite carrier has a triple network structure, comprising: a three-dimensional network backbone formed by cross-linking chitosan and sodium tripolyphosphate, constituting the first network; a functional enhancing phase, including Chlamydomonas reinhardtii protein, which is embedded and anchored in the three-dimensional network backbone through a first physical interaction, constituting the second network, thereby forming a chitosan-Chlamydomonas reinhardtii protein complex with an interpenetrating network structure; and a structure-directing agent, including a hydrophobic active substance, which self-assembles and embeds into the hydrophobic microregions of the chitosan-Chlamydomonas reinhardtii protein complex through a second physical interaction, constituting the third network. The composite carrier provided by this invention is prepared using electrospinning technology, achieving high loading capacity and high encapsulation efficiency, constructing a multi-layered antioxidant defense network, and can serve as a highly efficient and stable multifunctional carrier for the preparation of functional food delivery materials.

A probiotic microsphere with in-situ proliferation, its preparation method and application. The microsphere is prepared by a two-step Pickering double emulsion method, encapsulating probiotics and panax notoginseng saponins, and then mixed with sodium alginate and cross-linked by calcium ions. The structure significantly improves the survival rate of probiotics in simulated gastric juice, intestinal juice, heat treatment and antibiotic environment, and maintains high viable cell count during long-term storage. Co-encapsulated PNS and double emulsion stabilizer natural polysaccharide-protein nanocomposite can promote the proliferation of probiotics in-situ, increase their activity. In addition, the microsphere can effectively promote the colonization and proliferation of probiotics in the intestinal tract, enhance the oral bioavailability of bioactive ingredients, and is suitable for functional food, feed, biological medicine field, especially as 3D printing special medical food for dysphagia population and prevention and treatment of intestinal inflammatory diseases.

A Panax notoginseng polysaccharide iron nanoparticle preparation, its preparation method, and its application are disclosed. This invention can effectively prepare Panax notoginseng polysaccharide iron nanoparticles, solving the application problem in the preparation of drugs for treating iron deficiency anemia, inflammatory bowel disease-related anemia, iron deficiency anemia-related colitis, inflammatory anemia, or inflammatory bowel disease. The specific steps are as follows: The crude Panax notoginseng polysaccharide solution is purified using conventional purification methods to obtain purified Panax notoginseng polysaccharide. This purified polysaccharide is dissolved in ultrapure water, and an iron source is added under inert gas protection. After co-precipitation and chemical reduction reactions, the pH value is adjusted, and iron nanoparticles are loaded onto the Panax notoginseng polysaccharide to obtain Panax notoginseng polysaccharide-coated iron nanoparticles. The preparation method of this invention is simple, uses abundant raw materials, and has low production costs. It represents a major innovation in drugs for treating iron deficiency anemia and inflammatory bowel disease-related iron deficiency anemia, and has practical application value.

The application belongs to the technical field of medical nutritional foods, and particularly relates to a composite peptide nutritional composition for promoting wound healing and a preparation process and application thereof. The composite peptide nutritional composition for promoting wound healing is prepared from raw materials including fish collagen peptide 15%-25%, bovine spleen peptide 0.03%-0.05%, blood protein oligopeptide 0.10%-0.30%, albumin peptide 0.10%-0.30%, ginseng powder 0.01%-0.03%, composite fermentation extract 15%-20%, plant extract 10%-20%, prebiotic 20%-25%, and whey protein matrix supplementing the rest to 100% by weight percentage. The application improves the content of healing-promoting peptide segments and various active ingredients such as anti-inflammatory repair by using self-made fish collagen peptide, composite fermentation extract and other raw materials, and improves the bioavailability of plant extract through embedding technology, thereby significantly improving the wound healing rate and quality.

This invention relates to a method for preparing resveratrol nanoparticles, belonging to the field of traditional Chinese medicine technology. Addressing the problems of low oral bioavailability and lack of colonic targeting of resveratrol, this invention provides a nanoparticle formulation composed of resveratrol, zein, and xylan. The formulation is prepared by dissolving resveratrol and zein in an organic phase, adding them dropwise to an aqueous xylan phase, and then evaporating the organic solvent. This invention utilizes the hydrophobic effect of zein to improve drug encapsulation efficiency and leverages the colonic degradation characteristics and anti-inflammatory activity of xylan to achieve synergistic effects, enabling precise release of resveratrol at sites of intestinal inflammation.

The application discloses aryl benzimidazole compounds of formula I, pharmaceutical compositions and applications thereof. The compounds and the pharmaceutical compositions have specific GLP-1 agonistic activity, and are agonists of glucagon-like peptide-1 receptor (GLP-1R). Therefore, the compounds can be used for preparing medicines for preventing and / or treating GLP-1 mediated diseases or related diseases.

The invention discloses a beta-lactamase inhibitor, which is selected from a compound with a structure shown as a formula I or pharmaceutically acceptable salts, isomers or deuterated substances of the compound. The invention discloses an application of the beta-lactamase inhibitor in preparation of the beta-lactamase inhibitor. The invention also discloses application of the beta-lactamase inhibitor in preparation of medicines for treating diseases related to bacterial infection. The bacteria are bacteria capable of producing beta-lactamase. The beta-lactamase inhibitor disclosed by the invention can quickly and completely release active metabolites such as avibactam, dulobactam, relebactam, nacchabactam and other diazabicyclo beta-lactamase inhibitors in vivo, and can quickly take effect, so that the oral bioavailability of the beta-lactamase inhibitor is effectively improved, the bioavailability of the beta-lactamase inhibitor is improved, and the bioavailability of the beta-lactamase inhibitor is improved. Therefore, the diazabicyclo beta-lactamase inhibitor can be orally taken, and the problem of low oral bioavailability of the diazabicyclo beta-lactamase inhibitor is solved.