59results about How to "Convenient route of administration" patented technology

A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

An orally deliverable pharmaceutical composition comprises (a) a pharmaceutically acceptable acid addition salt of ABT-263 in solid particulate form, and (b) a plurality of pharmaceutically acceptable excipients including at least a solid diluent and a solid disintegrant; wherein the salt is formed from more than one equivalent of acid per equivalent of ABT-263. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

An orally deliverable pharmaceutical composition comprises as a sole or first active ingredient a compound of Formula I defined herein or a pharmaceutically acceptable salt thereof, for example ABT-263 free base or ABT-263 bis-HCl salt, dispersed, in a free base equivalent amount of at least about 2.5% by weight of the composition, in a pharmaceutically acceptable carrier; wherein said active ingredient is in solid-state form and/or the composition further comprises, dispersed in the carrier, a pharmaceutically acceptable heavier-chalcogen antioxidant in an amount effective to inhibit oxidation of the active ingredient at a thioether linkage thereof. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound, e.g., ABT-263, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

A liquid pharmaceutical composition comprises an aqueous medium having suspended therein a solid particulate Bc1-2 family protein inhibitory compound such as ABT-263, having a D₉₀ particle size not greater than about 3 μm; wherein the aqueous medium further comprises at least one pharmaceutically acceptable surfactant and at least one pharmaceutically acceptable basifying agent such as sodium bicarbonate in amounts that are effective together to inhibit particle size increase. The composition is suitable for oral or parenteral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bc1-2 family proteins, for example cancer.

ABT-263 bis-HCl and crystalline polymorphs thereof are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

An orally deliverable pharmaceutical composition comprises a Bcl-2 family protein inhibitory compound, e.g., ABT-263, a heavier-chalcogen antioxidant and a substantially non-aqueous lipid carrier, wherein said compound and said antioxidant are in solution in the carrier. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

A solid dispersion comprises, in essentially non-crystalline form, a kinase inhibitory compound, e.g., N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N′-(3-fluorophenyl)urea, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a cancer.

An orally deliverable pharmaceutical composition comprises a drug-carrier system having a Bcl-2 family protein inhibitory compound, e.g., ABT-263, in solution in a substantially non-aqueous carrier that comprises at least one phospholipid and a pharmaceutically acceptable solubilizing agent. The composition is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

A pharmaceutical capsule comprises a shell having encapsulated therewithin a liquid solution of ABT-263 or a pharmaceutically acceptable salt thereof in a substantially non-ethanolic carrier that comprises as pharmaceutically acceptable excipients (a) at least one phospholipid, (b) at least one solubilizing agent for the at least one phospholipid, selected from the group consisting of glycols, glycerides and mixtures thereof, (c) at least one non-phospholipid surfactant and (d) at least one sulfur-containing antioxidant. The capsule is useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

The invention provides a recombinant expression vector for expressing LL-37 polypeptide, recombinant lactococcus lactis, an antiviral drug, a construction method and application, and belongs to the technical field of gene engineering. A skeleton plasmid for constructing the recombinant expression vector is PNZ8149; a fusion gene is inserted into the recombinant expression vector; the nucleotide sequence of the fusion gene is shown as SEQ ID NO: 1. The recombinant expression vector disclosed by the invention can be efficiently expressed in lactococcus lactis, and the LL-37 obtained by expression can effectively inhibit SARS coronavirus and SARS-CoV2 coronavirus. The invention also provides recombinant lactococcus lactis containing the recombinant expression vector in the scheme. According to the recombinant lactococcus lactis disclosed by the invention, an antiviral polypeptide drug LL-37 can be input into a human body in an oral form, the antiviral effect is good, and the production cost is low.

An navel plaster is prepared from 15 Chinese-medicinal materials including atractylodes rhizome, bitter orange, agastache, cloves, etc. Its preparing process is also disclosed.

The invention discloses an enema liquid for treating hyperpyrexia and cough and asthma, which is prepared by using stiff silkworm, curcuma longa, cicada slough, wine-processed rhubarb, raw ephedra herb, cassia twig, gypsum, almond, earthworm, red paeony root, tangerine peel, mix-fried tatarian aster root and mix-fried liquoric root as the raw material through the following steps: firstly adding water into gypsum to decoct; after decocting, adding the decocted gypsum in other raw material medicaments which are marinate in advance to decoct; and after decocting the raw material medicaments, filtering out a medicinal liquid, i.e. the enema liquid for treating hyperpyrexia and cough and asthma. The product of the invention mainly has the effects of expelling wind and cold pathogens externally, hot and suffocating of upper, middle and lower warmer internally, clearing and descending lung qi, purging fu-organs and relieving flatulence, relieving cough and asthma and relieving dizziness and convulsion, and is suitable to treat high fever in children, cough and dyspnea and tachypnea or the diseases with symptoms of aversion to cold, lassitude, syncope with convulsion, clonic convulsion and the like. The medicament formula of the product of the invention directly guides and is applied clinically according to the principles of Chinese medicine. The clinical curative effect shows that the product of the invention has the advantages of quick response, recurrence prevention, no any toxic or side effects, obvious treating effect and valuable popularization and application.

The invention discloses a medicine for treating hypomenorrhea due to the deficiency of the kidney and a preparation method thereof. The medicine is prepared from the following medicinal raw materials: dried human placenta, eucommia bark, flastem milkvetch seeds, tokay, hairy antlers, sea horses, ursine seal testes and penes, prepared rhizome of adhesive rehmannias, dried longan pulp, cochinchinese asparagus roots, noble dendrobium stems, manyflower solomonseal rhizomes, barbary wolfberry fruits, glossy privet fruit, tortoise shells, rose flowers, gaulis aristolochiae, Danshen roots, twotooth achyranthes roots, suberect spatholobus stems, goat or sheep testes, dragonflies, Elaphurus Davidianus Milne-Edwards, greywhitehair raspberry fruits, air bladders of yellow croakers, freshwater sponge, wild groundnut seeds, cushaw stems, dahurian rose fruits and ford metalleaf roots. The medicine has the functions of nourishing the kidney, strengthening the essence, nourishing blood and regulating menstruation and is mainly used for treating hypomenorrhea due to the deficiency of the kidney. The medicine is prepared by integrating the concept of wholism with the treatment based on syndrome differentiation, can be used for improving the overall function, state and immunity of the human body, regulating qi and blood and improving the metabolism of blood, is targeted at hypomenorrhea due to the deficiency of the kidney, can take effect on the diseased part directly, is short in course of treatment, causes less adverse reactions, is safe and efficient, can be used selectively according to different clinical symptoms, can be applied conveniently and can be easily accepted by patients, and patients can not become resistant to the medicine.

The invention discloses a Chinese herbal compound functional food for adjuvant therapy of diabetes and a preparation method thereof. The Chinese herbal compound functional food consists of the following raw materials: a burdock root extract, a pueraria extract, a rhizoma polygonati extract, vitamin C, xylooligosaccharide, xylitol, an arabian jasmine flower extract and magnesium stearate. Accordingto the Chinese herbal compound functional food for adjuvant therapy of diabetes, the postprandial blood sugar and fasting blood-glucose can be reduced effectively, the food can be used for adjuvant therapy of diabetics, the food is reasonable in formula and high in safety and has prevention and treatment effects for diabetic complications, the kidney injury degree of diabetics can be improved, the life cycle of diabetics is prolonged, and the life quality of diabetics is improved; the Chinese herbal compound functional food for adjuvant therapy of diabetes disclosed by the invention is rich in hypoglycemic activity substances such as fructo-oligosaccharides, polysaccharides, anthraquinone compounds and various amino acids and vitamins, is sour and sweet and unique in flavor, and has the functions of health care and nutrition.

The invention discloses recombinant adenovirus, a preparation method and application. The preparation method comprises the following steps: cloning a TMEM88 gene into a cloning region of adenovirus shuttle plasmids and constructing recombinant shuttle plasmids for expressing TMEM88; co-transforming the recombinant shuttle plasmids and adenovirus framework plasmids into host cells; carrying out homologous recombination to generate recombinant adenovirus plasmids; packaging through packaging cells to obtain adenovirus particles with infection activity and amplifying in the packaging cells; aftercollecting and cracking the packaging cells, purifying to obtain the recombinant adenovirus. According to the recombinant adenovirus, adenovirus is used as a carrier and is safe and reliable; the adenovirus is not combined with host chromosome DNA (Deoxyribonucleic Acid) and the risk of canceration is not caused; the recombinant adenovirus has a remarkable effect on hepatic fibrosis and the reversing effect can be observed with a single injection. The recombinant adenovirus is convenient for drug administration due to the drug administration manner; the recombinant adenovirus is introduced into rats by adopting a tail vein injection manner. The best time for reversing the hepatic fibrosis is obtained.

The invention discloses application of a compound Nib1, a pharmaceutically acceptable salt, a solvate, a solvate of the pharmaceutically acceptable salt or a crystal form thereof in preparation of a medicine for treating autoimmune skin diseases caused by inflammation, improving skin erythema, improving skin decrustation, reducing skin thickening, reducing epidermal hyperplasia, improving angiectasis and/or reducing immune cell infiltration. The chemical formula of the Nib1 is C28H29F2N3O. The compound provided by the invention is a new treatment mechanism aiming at autoimmune skin diseases (such as psoriasis diseases) caused by inflammation, is small in side effect and convenient in administration route, can achieve the balance of safety and effectiveness, can be used for a long time, andimproves the life quality of patients. The compound can significantly improve clinical symptoms of autoimmune skin diseases caused by inflammation, such as erythema cutanea, skin peeling, skin thickening, epidermal hyperplasia, improve angiectasis and reduce immune cell infiltration and the like.

The invention discloses lipid-lowering buccal tablets, which are characterized by comprising the following components in part by weight: bottle brush herb extract 20-30, rosa davurica extract 16-25, hawthorn extract 17 to 25, isomaltitol 12-17, sucrose 6-12, starch 5-8, magnesium stearate 4-7 and sodium essence 0.3-0.4. The health-care blood lipid lowering buccal tablets have the characteristics of high active ingredient content, easy administration, excellent mouthfeel and quick absorption, and a more convenient administration approach is provided for the clinic treatment, health care and treatment of hyperlipidemia.

The invention discloses a liquid traditional Chinese medicine for treating verruca plana and a preparation method thereof. The liquid traditional Chinese medicine is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 15-25 parts of oldenlandia diffusa, 15-25 parts of opuntia stricta, 10-20 parts of herba portulacae, 10-20 parts of salvia miltiorrhiza, 10-20 parts of clerodendrum bungei, 5-15 parts of sedum lineare, 5-15 parts of radix semiaquilegiae, 5-15 parts of flos sophorae, 4-12 parts of frankincense, 2-8 parts of periostracum cicada, 2-8 parts of peppermint and 0.02-0.06 part of cantharides. The liquid traditional Chinese medicine is prepared by adopting common traditional Chinese medicinal materials as raw materials, is convenient in administration route, quick in response and low in cost, does not have irritation, toxic or side effect, has remarkable curative effect, prevents scar or relapse, has the effects of clearing heat, removing toxicity, nourishing blood, dispelling wind, regulating liver, strengthening spleen, softening hard mass and removing verruca, and can be used for quickly and effectively treating verruca plana.

The invention provides a nanometer-lipophilic drug preparation of hydrogenated castor oil and the preparation method of the nanometer-lipophilic drug preparation. The nanometer drug preparation consists of a lipophilic drug, the hydrogenated castor oil and little polyvinyl alcohol. The nanometer-lipophilic drug preparation of hydrogenated castor oil of the invention has the efficacy of slowly releasing and at the same time is capable of improving the dispersion of the drug, the utilization degree of the drug and the drug effect, and that the storage, the transportation and the administration route of the drug are more convenient.