The invention relates to a drug for treating the symptom of deficiency of qi and blood and a preparation method of the drug. Deficiency of qi and blood is mainly shown as follows: deficient breath, laziness to speak, fatigue and weakness of the whole body, lowness in voice, dizziness, lacking in strength, giddiness, palpitation, insomnia and dreaminess, sallow and pale complexion, pale and fat tongue, tooth prints on the edge of the tongue, weak pulse and the like as well as delay of menstruation, hypomenorrhea and light color of menstrual blood for women, glossy fur, few fluids and the like. At the moment, a qi tonifying and blood replenishing method should be taken. The drug is prepared from ginseng, mulberries, American ginseng, chicken's gizzard-membranes, turtle shells, largehead atractylodes rhizomes, yams, radish seeds, black sesame, rock candy, cordyceps sinensis, grain sprouts, glossy privet fruits, herba cistanches, heterophylly falsestarwort roots, malt, astragalus membranaceus, epimedium, medicinal indianmulberry roots, hawthorn fruits, antler glue, tuber onion seed, angelica sinensis, prepared rehmannia roots, Chinese dwarf cherry seeds, tuber fleeceflower roots, malaytea scurfpea fruits, donkey-hide gelatin, adenophora stricta miq, Chinese mosla herbs, lilies, fructus lycii, sharpleaf galangal fruits, negundo chastetree fruits, milkvetch seeds and South dodder seeds through combination. The medicinal materials are combined to have a synergistic effect, and the symptom of deficiency of qi and blood can be effectively treated.