53 results about "Abortion" patented technology

The invention discloses a pig farm abortion attribution diagnosis method based on a porcine reproductive and respiratory syndrome risk propagation knowledge graph, and relates to the technical field of artificial intelligence, and the method comprises the steps: constructing a pig farm porcine reproductive and respiratory syndrome attribution knowledge graph, pre-defining a risk propagation mode according to a porcine reproductive and respiratory syndrome risk propagation mechanism, searching a path according with the risk propagation mode through graph mode matching, and carrying out the diagnosis of the abortion attribution of a pig farm. Integrating into a risk sub-graph; performing representation learning on the risk sub-graphs by adopting a graph attention network fused with PRRS risk propagation knowledge, and quantifying the contribution degree of each risk sub-graph to the abortion rate of the pig farm in combination with context representation learning and a time difference attenuation mechanism; and based on the contribution proportion of each risk event in the attention score decomposition risk sub-graph, generating a quantitative attribution result, and outputting a diagnosis result including risk event identification, a risk propagation link and a quantitative attribution contribution degree. Risk attribution of the porcine reproductive and respiratory syndrome in the pig farm is realized, and contribution of specific attribution risk points to the abortion rate of the pig farm is quantified.

The invention provides a sustained-release microneedle for treating ill-conditioned pregnancy and a preparation method and application thereof, and relates to the technical field of biological medicines.The sustained-release microneedle for treating ill-conditioned pregnancy comprises a base and a needle tip on the base, the needle tip part of the gel microneedle is made of heparin medicine, and the needle tip part of the gel microneedle is made of gelatin. The heparin medicine comprises heparin, heparin sodium, low-molecular heparin, low-molecular heparin sodium or low-molecular heparin calcium; the needle point part comprises a heparin photo-crosslinking monomer, and the base comprises a biocompatible polymer matrix. The sustained-release microneedle for treating pathological pregnancy provided by the embodiment of the invention has good mechanical strength, skin permeability and anticoagulant activity, can reduce skin bruises caused by subcutaneous injection of heparin, improves abortion caused by infection and inflammation and abortion caused by APS (anti-phospholipid antibody syndrome), can realize sustained release of drugs and increase of drug loading capacity, and has good application prospects. Sustainable drug delivery is achieved, and frequent injection is avoided.

The invention relates to a recurrent abortion early-warning method based on maternal and fetal immune interaction characteristics, which comprises the following steps: by taking decidua immune cells and trophoblasts as a unit, defining the regulation intensity of a key path of a path in an immune receptivity state; evaluating the coordination degree of signals among different cells by utilizing an information theory method; introducing a maternal and fetal immune receptivity steady-state index UISI; through continuous time sampling analysis, an immune signal offset track is identified; establishing an interactive imbalance index (IEI), and quantifying the imbalance intensity; designing a disturbance and response test; fitting the response trend of the IEI change to the disturbance into a system response curve IRC, and quantifying the recovery capability of the immune system; the IRC and individual clinical features are fused, and a dynamic risk thermodynamic relation is established; intervention window weight factors are constructed, wherein the intervention window weight factors comprise the fluctuation amplitude, the recovery period and the UISI critical value proximity; outputting a dynamic intervention suggestion map, and prompting a doctor to observe a period and a drug intervention starting point; the early warning capability is strong, and the limitation of traditional passive diagnosis is broken through.

The invention provides application of injectable bioactive hydrogel in treatment of recurrent abortion, and relates to the technical field of biomedicine, and the technical key points are as follows: aldehydic hyaluronic acid and chitosan are connected in parallel, the injectable bioactive hydrogel is developed, and the hydrogel is loaded with LIF, VEGF, IL-11 and valproic acid to enhance regeneration activity. According to the application, the effect is evaluated in vitro through a specific verification experiment. Results show that the hydrogel prepared by the application shows rapid gelation, good biocompatibility and factor loading capacity, and enhances the proliferation of human endometrial stromal cells and the vascularization capacity of human umbilical vein endothelial cells. In macrophages, the expression of a proinflammatory cytokine is down-regulated, and the expression of an anti-inflammatory cytokine IL-10 is up-regulated. In conclusion, the HA-CHO / chitosan hydrogel in the application supports endometrial regeneration by synergistically promoting proliferation, angiogenesis, immune regulation and receptivity.

The invention belongs to the technical field of reproductive medicine and clinical metabolism intervention, and particularly relates to a group of markers for diagnosing unexplained recurrent abortion and application thereof. Aiming at the clinical pain point that unexplained recurrent abortion (URSA) lacks accurate metabolic typing diagnosis indexes and targeted treatment means, based on detection of a large number of clinical samples and verification of cell experiments, direct association between down-regulation of levels of choline related metabolites and trimethylamine oxide (TMAO) of decidua tissues and the RSA is disclosed for the first time; the core effect of TMAO in-situ synthesis of decidua stromal cells (DSC) in regulation and control of the decidualization process is determined; meanwhile, an RSA indication screening system of joint detection of serum creatinine and decidua choline metabolism is constructed, a targeted TMAO targeted intervention scheme is formed in a matched mode, a diagnosis and treatment closed loop of RSA from precise typing to targeted treatment is achieved, and a brand new technical path is provided for clinically solving the URSA diagnosis and treatment problem.

The invention relates to a preparation method of a placenta trophoblast-derived transporter and application of the placenta trophoblast-derived transporter in a medicine for treating spontaneous abortion, which comprises the following steps of: taking out a placenta of a suckling mouse, cutting the placenta into fine tissue blocks, resuspending by using digestive juice, digesting in a water bath kettle at 37 DEG C for 20 minutes, and then stopping digestion by using 1640 culture containing high-temperature heat-inactivated fetal calf serum; diluting and neutralizing collagenase digestive juice according to 5 times of volume; and centrifuging the collagenase digestive juice for multiple times to obtain a precipitate, namely the exosome. And carrying out density gradient centrifugation on the coarse migration body by using Optiprep as a density medium, washing, precipitating and centrifuging by using PBS on an ultra-high-speed centrifuge by using a horizontal rotor to obtain the placental trophoblast source migration body. The invention finds that the generation of the placental trophoblast cell source migration body is related to the physiological process of pregnancy for the first time, and the placental trophoblast cell source migration body can enter the circulatory system and reach the placenta through in-vitro supplementation.

The present application belongs to the field of biological medicine and molecular biology technology, and particularly relates to a marker for predicting the occurrence of repeated implantation failure and application thereof. The present application finds that abnormal lipid peroxidation in uterine epithelium can cause implantation defects, and the lipid peroxidation level of the uterus in patients with repeated implantation failure or repeated spontaneous abortion is enhanced, wherein the content of active aldehyde substance MDA and non-heme iron in serum can be used as a new non-invasive clinical index for predicting RIF patients; further, eliminating uterine lipid ROS to improve endometrial receptivity can be used as a potential new treatment strategy to improve embryo implantation and clinical pregnancy rate, and therefore has good practical application value.

The invention belongs to the technical field of biomarkers, and particularly relates to a marker for unexplained recurrent spontaneous abortion and application of the marker. The marker is at least one of LARP1, LSM1 and NCBP2 (National Center For Biotechnology Protein). The invention has the following beneficial effects: the expression of six m7G regulatory factors in URSA is abnormal: LSM1 and NUDT16 are up-regulated, and IFIT5, LARP1, NCBP2 and NUDT4 are down-regulated (P < lt >; 0.05). Machine learning determines that LSM1, LARP1 and NCBP2 are high-performance diagnostic biomarkers, and the diagnostic values of the high-performance diagnostic biomarkers are verified by qRT-PCR and immunofluorescence in independent samples.

The present application relates to the technical field of biological medicine, and more particularly to the application of isodon japonicus in the preparation of a drug for preventing and treating spontaneous abortion. The present application analyzes the in-vivo migration components of Jianwei Shoutai Pills, excavates the pharmacodynamic material basis for preventing and treating spontaneous abortion, and uses a CBA / J x DBA / 2 peri-implantation period abortion mouse model to conduct pharmacodynamic experiments. The results show that isodon japonicus can significantly reduce the abortion rate of the CBA / J x DBA / 2 peri-implantation period abortion model mice, and can effectively increase the embryo and placenta wet weight of the CBA / J x DBA / 2 peri-implantation period abortion model mice. That is, isodon japonicus can effectively inhibit spontaneous abortion, has a significant curative effect, has considerable treatment potential, provides a potential new drug selection for clinical drugs for preventing and treating spontaneous abortion, and has a broad application prospect.

The present application belongs to the technical field of genetic engineering, and relates to application of a tobacco chloroplast psbY gene or a coded protein thereof in regulation of abortion of tobacco. The present application causes shortened tobacco filaments and abnormal pollination by overexpression of the psbY gene, thereby causing abortion of the tobacco. Meanwhile, a breeding method for a tobacco male sterile line is proposed based on the application, that is, a transformation vector containing the tobacco chloroplast psbY gene is transformed into the genome of the tobacco by using an agrobacterium-mediated genetic transformation method, and a tobacco male sterile line variety with overexpression of the psbY gene is obtained. The present application firstly discovers and proves that the tobacco chloroplast protein psbY can be used for regulation of abortion of the tobacco, overexpression of the psbY gene can cause shortened tobacco filaments, the stigma is far higher than the anther, and the tobacco cannot be normally pollinated, thereby causing abortion of the tobacco. This has important theoretical significance and practical value for research on the tobacco male sterility, and creates a new prospect for tobacco breeding.

The present invention provides a visible abortion suction tube, belonging to the technical field of surgical medical devices, comprising: a handle and a suction tube disposed on the handle, wherein a camera is provided at the head of the suction tube; the suction tube is rotatably connected to the handle about an axis, at least part of the suction tube is a controllable swing section, and a steering member for controlling the swing angle of the controllable swing section is connected to the handle; for the visible abortion suction tube of the present invention, at least part of the suction tube is set as a controllable swing section, and a steering member for controlling the controllable swing section is provided on the handle, so that during the operation, the swing angle of the controllable swing section can be adjusted; in addition, the connection between the suction tube and the handle is set such that the suction tube can rotate about the axis, so as to cooperate with the controllable swing section, thereby enabling the angle of the camera at the head of the suction tube to be adjusted in all directions, improving the convenience of the operation process and the precision of the abortion operation.

The invention relates to application of arachidonic acid (ARA) in preparation of a medicine for treating sleep disorder related spontaneous abortion. Peripheral blood lipid metabolism sequencing analysis finds that the ARA content in peripheral blood serum of a patient suffering from sleep disorder and repeated pregnancy loss is most obviously reduced compared with that of a patient suffering from normal sleep and normal pregnancy; an enzyme-linked immunosorbent assay test shows that the content of ARA in decidua stromal cells (DSCs) of a patient with sleep disorder and repeated pregnancy loss is remarkably reduced compared with that of a pregnant person with normal sleep; after the endometrial stromal cells (ESCs) are subjected to ARA treatment, the in-vitro decidualization level is increased; the ARA inhibitor can be used for inhibiting the in-vitro deciduation level of the ESCs; compared with a mouse with normal sleep, the content of ARA in peripheral blood and DSCs of a mouse with sleep disorder is remarkably reduced, decidua is poor, and the abortion rate is increased; supplementing ARA can improve decidua disorder and high abortion rate caused by sleep disorder. Therefore, a potential target and a new idea are provided for diagnosis and treatment of repeated pregnancy loss related to sleep disorder.

The invention relates to the field of animal husbandry molecular breeding and precise breeding, in particular to an animal husbandry improved variety breeding twin-fetal cattle system based on gene screening. The system comprises an ovulation potential typing module, a uterine bearing capacity quantification module, a sex compatibility verification module and a decision module. Constructing a combined evaluation model of the double-ovulation basis and the uterus metabolism capability by systematically integrating site specific amplification and gene expression quantification technologies; the core of the method is that a precise reproduction instruction is generated according to full-link data of genotypes and phenotypes; according to the method, a single ovulation rate screening mode is changed, the problem of abortion and weak abortion caused by insufficient intrauterine environment is effectively solved, and the success rate of double-fetal pregnancy is remarkably increased.

The application discloses application of CD52 protein in preparation of a medicine for treating recurrent spontaneous abortion, and belongs to the technical field of biological medicine. It is found that the CD52 protein can target and inhibit abnormal activation of effector T cells at a maternal-fetal interface, reduce release of proinflammatory factors (such as IFN-gamma), thereby reversing immune tolerance imbalance and improving pregnancy outcome. The CD52 protein is applied to the treatment of recurrent spontaneous abortion for the first time, and has the advantages of high targeting and high safety.

The invention provides a leakproof hysteroscope, and relates to the field of medical instruments, the leakproof hysteroscope comprises a main pipe, one end of the main pipe is fixedly connected with an extension pipe, the surface of the extension pipe is sleeved with an air bag part, the top of the outer arc surface of one end of the air bag part is provided with a liquid inlet pipe, the middle of the main pipe is movably clamped with a support, and one end of the liquid inlet pipe is movably clamped on the support; connecting pieces are fixedly connected to the bottoms of the outer surfaces of the main pipes. Through the arrangement of the support, the air bag part, the liquid inlet pipe, the water stop ball, the connecting rod, the temporary storage part and the flowing groove, liquid injection operation on the device is achieved, the air bag part is effectively expanded, the inner wall of the cervix uteri is gradually extruded and attached, then the gap between the cervix uteri and the device is reduced, medium leakage is effectively avoided, and the problem that in the prior art, in the using process, medium leakage is caused is solved. Cervical relaxation of a patient is very easy to occur due to fetus, normal delivery, uterine curettage or multiple induced abortion times, frequent perineal examination, delivery injury and the like, and the problem of medium leakage is very easy to occur due to the fact that the number of the cervical relaxation is combined with cervical hypertrophy.

The invention discloses an intelligent attribution method for a continuous integration assembly line abortion problem, and the method comprises the steps: collecting a key abortion log, a code change context, an assembly line configuration context and a domain knowledge template through a multi-dimensional data mining pipeline in a structured manner; a two-stage retrieval mechanism is combined with a position-sensitive reverse ranking fusion algorithm to accurately match historical related cases from a hierarchical abortion case knowledge base, and a retrieval enhancement generation technology is utilized to drive a large language model to perform thinking chain reasoning. And dynamically optimizing the attribution result through a confidence evaluation strategy, and reversely updating the audited case features to the knowledge base to form a self-supervision expansion capability. According to the method, fine-grained accurate classification of six types of typical assembly line abortion problems can be realized, a user can be helped to quickly and accurately judge problem types and abortion reasons and provide effective detailed description support, the workload of abortion problem investigation is greatly reduced, and the robustness of a continuous integrated assembly line is effectively guaranteed.

The invention discloses an RIF whole course management method, which comprises the following steps: by adopting a next generation sequencing (NGS) technology, 24 chromosomes can be covered, whole chromosome aneuploidy can be screened, the detection resolution is below 1Mb, and microdeletion / microrepetition can be identified. Compared with a traditional array-CGH technology, the method has the advantages that the epiploid embryo screening precision is remarkably improved by 30%, high-quality embryos with normal chromosomes can be selected, the embryo implantation success rate is greatly improved, the abortion risk is reduced, bad pregnancy knots caused by chromosome abnormality are reduced, embryo development is dynamically recorded with the frequency of one frame every 10-20 minutes through a time-difference imaging system, and the screening accuracy of the epiploid embryos is improved. Key time nodes are analyzed through an AI algorithm, an embryo potential scoring model is constructed in combination with morphological parameters, and the prediction implantation probability accuracy rate reaches 75% or above. Scientific basis is provided for clinicians to select the embryo with the highest implantation potential, blind transplantation is avoided, and the success rate of test tube babies is increased.

The application discloses a functional natural plant composition for preventing and treating latent mastitis in a pregnant and lactating stage of a dairy cow and a preparation method and application thereof, and comprises the following raw materials: eucommia leaf 10-50 parts, radix paeoniae alba 5-25 parts, semen euryae 10-40 parts, dandelion 10-40 parts, perilla leaf 5-20 parts, white kidney bean 10-30 parts and licorice 5-20 parts. The functional natural plant composition is safe and reliable, has small toxic and side effects, no drug resistance, high absorption rate and no harmful residues in the dairy cow. The functional natural plant composition has the functions of nourishing liver and kidney, invigorating spleen and drying dampness, clearing heat and detoxifying, eliminating swelling and promoting abortion, can improve the constitution of the dairy cow in the pregnant and lactating stage by enhancing the functions of the spleen and stomach and tonifying liver and kidney, can intervene pathogenic microorganisms and treat initial infection of the breast by using traditional Chinese medicine to play the roles of inhibiting bacteria, resisting oxidation, resisting inflammation and eliminating swelling, and can also have the functions of promoting abortion and promoting healthy development of the fetus.

The invention provides a combined marker for predicting intrauterine adhesion after abortion curettage, a kit and application, and belongs to the technical field of biological detection. The method comprises the following steps: prospectively collecting macrophages of decidua of a subject, wherein the subject is in Damp; the method comprises the following steps of: selecting a non-IUA group and an IUA group according to B ultrasonic follow-up visit results of two months after operation, and analyzing gene differential expression of macrophages of the two groups of subjects, difference of intrauterine microbiota and change of serum metabolites to finally obtain a method capable of accurately predicting intrauterine adhesion after abortion curettage operation. According to the method, the model efficiency of predicting intrauterine adhesion after abortion curettage is as high as 97.8%, and the method has the advantages of being low in cost and simple and rapid in detection method and has a large application prospect.

The invention relates to an application of lactobacillus plantarum L168 in a medicine for improving inflammation level in a gestation period and resisting abortion caused by transitional immune stimulation, and belongs to the technical field of microorganism application, the lactobacillus plantarum L168 strain is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.13660. The lactobacillus plantarum L168 has the advantages that the lactobacillus plantarum L168 strain can be applied to preparation of medicines for improving inflammation level in the gestation period and resisting abortion caused by transitional immune stimulation, and the lactobacillus plantarum L168 strain can be applied to preparation of medicines for improving inflammation level in the gestation period and resisting abortion caused by transitional immune stimulation. The lactobacillus plantarum L168 disclosed by the invention can be used for effectively inhibiting excessive inflammatory response in a gestation period, reducing the risk of abortion caused by immunostimulation, improving a maternal immune microenvironment and promoting healthy development of a fetus, and is high in safety and easy to take as a natural probiotic preparation. The method can be widely applied to health management products in the gestation period, especially to adjuvant therapy and preventive intervention of high-risk pregnant women, and has important clinical and commercial values.

The invention relates to a feed capable of preventing abortion of pregnant horses and a preparation method and application thereof, the feed is composed of corn straw, leguminous forage and non-leguminous forage, the feed contains 0-10% by mass of leguminous forage, and the total amount of the corn straw and the leguminous forage contained in the feed is less than or equal to 50%. The composition, proportion and nutritional ingredients of leguminous forage, non-leguminous forage and corn straw in the pregnant horse feed are scientifically adjusted, the content of conjugated estrogen in pregnant horse urine is remarkably increased, the content of unknown impurities B and C in the pregnant horse urine is remarkably reduced, and the separated and purified conjugated estrogen raw material medicine has the advantages of being high in extraction rate, good in stability and the like. The adverse reactions such as diarrhea, abdominal distension and incapability of lying on the ground of the pregnant horse and the abortion rate of the pregnant horse are obviously reduced.

The application belongs to the technical field of biomarkers, and particularly relates to a marker for unexplained recurrent spontaneous abortion and application thereof. The marker is at least one of LARP1, LSM1 and NCBP2. The application has the advantages that in URSA, the expression of 6 m7G regulatory factors is abnormal: LSM1 and NUDT16 are up-regulated, and IFIT5, LARP1, NCBP2 and NUDT4 are down-regulated (P<0.05). Machine learning determines that LSM1, LARP1 and NCBP2 are high-performance diagnostic biomarkers, and the diagnostic value thereof is verified by qRT-PCR and immunofluorescence in independent samples.

The present application relates to the technical field of antibodies, in particular to a preparation method and application of a progesterone recombinant monoclonal antibody, wherein an excellent progesterone recombinant rabbit monoclonal antibody is screened, the heavy chain variable region of the antibody has an amino acid sequence as shown in SEQ ID NO:1, and the light chain variable region of the antibody has an amino acid sequence as shown in SEQ ID NO:2. Experimental results show that the progesterone recombinant rabbit monoclonal antibody protein has a large expression amount, high specificity and high sensitivity, and can be applied to early spontaneous abortion risk assessment, prediction of adverse pregnancy, determination of ovulation, evaluation of luteal function loss and other clinical diagnoses, meanwhile, the antibody is applied to detection of progesterone content in serum, and has high accuracy, good repeatability, strong stability and good clinical application value.

The invention provides application of a reagent for detecting KAT5 or H2A.Zac in preparation of a product for diagnosing placenta-derived diseases, and relates to the technical field of biomedicine. Experimental research of the inventor finds that chromosomes of trophoblasts in placentas of patients with repeated pregnancy loss are unstable, and expression of KAT5 and H2A.Zac is remarkably reduced. Experiments prove that KAT5-mediated H2A. Zac reduction is a main reason for reduction of trophoblast chromosome stability, so that the KAT5-H2A. Zac pathway provides a new action target for diagnosis and treatment of placenta-derived diseases, diagnosis and / or treatment of placenta-derived diseases can be realized, a new treatment strategy is provided for clinical improvement of poor pregnancy outcome, and the application of the KAT5-H2A. Zac pathway in diagnosis and treatment of placenta-derived diseases is developed. Therefore, the health level of female fertility can be improved, and gestation complications such as abortion and fetal growth limitation can be reduced.

The application discloses a pig farm abortion attribution diagnosis method based on a blue-ear disease risk propagation knowledge graph, relates to the technical field of artificial intelligence, and comprises the following steps: constructing a pig farm blue-ear disease attribution knowledge graph, predefining a risk propagation mode according to a blue-ear disease risk propagation mechanism, searching for a path conforming to the risk propagation mode through graph mode matching, and integrating the path into a risk subgraph; adopting a graph attention network fused with the blue-ear disease risk propagation knowledge to perform representation learning on the risk subgraph, combining context representation learning and a time difference attenuation mechanism to quantize the contribution degrees of the risk subgraphs to the abortion rate of the pig farm; based on attention score decomposition of the contribution proportions of the risk events in the risk subgraph, generating a quantitative attribution result, and outputting a diagnosis result including risk event identification, a risk propagation link and a quantitative attribution contribution degree. The application realizes risk attribution of the blue-ear disease of the pig farm and quantizes the contribution of specific risk points to the abortion rate of the pig farm.

The invention relates to the technical field of biology, in particular to application of human umbilical cord mesenchymal stem cells in preparation of drugs for recurrent spontaneous abortion and a pharmaceutical composition, and the human umbilical cord mesenchymal stem cells are used as NK cell migration and activation agents. According to the invention, the blank that the recurrent spontaneous abortion medicines do not have cellular medicines for regulating and controlling the migration and activation of the NK is filled up.

The invention discloses application of CD52 protein in preparation of a medicine for treating recurrent abortion, and belongs to the technical field of biological medicine. It is found that the CD52 protein can inhibit abnormal activation of maternal-fetal interfacial effect T cells in a targeted mode and reduce release of proinflammatory factors (such as IFN-gamma), so that immune tolerance imbalance is reversed, and the pregnancy outcome is improved. The CD52 protein is applied to treatment of the recurrent abortion for the first time, and the CD52 protein has the advantages of being high in targeting performance and high in safety.

The invention belongs to the technical field of reproductive medicine, and particularly relates to a natural abortion risk prediction and intervention system and method based on serum or plasma Activin A level detection, and the method comprises the following steps: S1, collecting a serum or plasma sample of a pregnant woman of 5-12 weeks of pregnancy; s2, detecting the concentration of Activin A in the serum or plasma sample by using a portable microfluidic detection device or an equivalent detection means; s3, 150 pg / ml is used as a critical value of Activin A, the pregnant women are divided into a low risk layer, a medium risk layer and a high risk layer, and the low risk is that the concentration of Activin A is lower than 100 pg / ml; according to the invention, based on the detection of the Activin A level of serum or plasma and in combination with the characteristics of high precision and rapid detection of the portable microfluidic detection device, the risk of spontaneous abortion of pregnant women can be predicted at the early stage of pregnancy (5-12 weeks). Compared with a traditional method, the method has the advantages that the prediction accuracy (the sensitivity is 92.3%, and the specificity is 88.5%) is improved, the risk of spontaneous abortion is warned 2-4 weeks ahead of time, and an earlier intervention opportunity is provided for doctors, so that the spontaneous abortion rate is reduced.

The utility model relates to the technical field of medical instruments, in particular to an abortion suction tube with an adjustable suction cavity, which comprises a holding part, a suction tube is arranged in the holding part in a penetrating manner, an end tube is fixed in the holding part, and the end tube is used for being connected with external vacuum equipment; wherein the end portion of the end tube is provided with an adjusting tube which is connected with the suction tube in an inserted mode, a locking mechanism is arranged between the suction tube and the holding portion, and the length of the suction tube can be adjusted according to operation requirements by adopting the design that the suction tube is connected with the end tube in an inserted mode. The design aims to improve the adaptability of surgical tools, so that the surgical tools can better adapt to the specific conditions of different patients; besides, in the operation process, a doctor can extend or shorten the suction tube through a simple button pressing mechanism so as to adapt to different operation depths, the tedious step that suction tubes with different lengths need to be replaced in a traditional operation is avoided through the instant length adjusting function, and the operation efficiency is remarkably improved.

This invention, through lipidomics and clinical sample validation, found that prospective follow-up of pre-pregnancy serum samples from women with a history of recurrent pregnancy loss (RPL) revealed that the pre-pregnancy serum levels of phosphatidylinositol PI (18:1 / 18:1) (i.e., PI 36:2), phosphatidylcholine (29:0-6:0) (i.e., PC 35:0), phosphatidylethanolamine (18:1p-18:2) (i.e., PE 36:3p), triglycerides (28:1-10:4-11:2) (i.e., TG 49:7), triglycerides (14:0-18:2-20:5) (i.e., TG 52:7), and wax esters (22:1) (i.e., WE 22:1) were significantly lower in these women than in those who subsequently achieved successful pregnancies. This confirms that the pre-pregnancy serum levels of these six lipids (PI 36:2, PC 35:0, PE 36:3p, TG 49:7, TG 52:7, WE 22:1) were significantly lower in these women than in those who subsequently achieved successful pregnancies. Decreased levels of 22:1 lipids were significantly associated with the risk of miscarriage in subsequent pregnancies. The area under the curve (AUC) of the predictive model constructed by combining six lipids reached 0.85, demonstrating good predictive efficacy. Based on these findings, this lipid combination can serve as a reliable predictor of miscarriage risk in subsequent pregnancies in RPL patients and can be used to develop diagnostic reagents or kits for preconception risk screening.