59 results about "Gestation period" patented technology

The invention belongs to the field of food, and particularly relates to application of a nutritional composition for assisting in improving memory ability. The invention provides application of a nutritional composition in preparation of food for assisting in improving memory ability of offspring. The nutritional composition comprises the following necessary components: active folic acid substances and fucosyllactose, moreover, in the nutritional composition, the mass ratio of the active folic acid substance to the fucosyllactose is (0.0001-0.0015): (0.5-10), the food is ingested by a mother to play the role of assisting in improving the memory ability of the offspring, the mother is in a gestation period and / or a lactation period, and the maternal is in the gestation period and / or the lactation period. The filial generation comprises a fetal-stage filial generation and / or an infant-stage filial generation and an optional child-stage filial generation. A large number of studies find that when active folic acid substances and fucosyllactose which are combined according to a certain proportion are supplemented to a mother at the beginning of the gestation period, the memory ability of offspring can be remarkably improved in an auxiliary mode.

The invention discloses a preparation method of a medicinal and edible traditional Chinese medicine composition for preventing and treating pregnancy complications. The medicinal and edible traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 24 parts of radix rehmanniae, 12 parts of fructus gardeniae and 9 parts of folium mori. The composition embodies the essence of compatibility of monarch, minister, assistant and guide of a traditional Chinese medicine compound, the radix rehmanniae is used as a monarch drug, the fructus gardeniae is used as a minister drug, the folium mori is used as an assistant drug, and the composition is mainly characterized by nourishing the kidney, containing wood, clearing away fire, calming the liver and lightly dredging upper jiao and exactly conforms to the core pathogenesis of yin deficiency and yang hyperactivity of gestational hypertension. Modern pharmacological experiments prove that the three traditional Chinese medicinal materials all have definite antihypertensive activity, and the action mechanism shows the characteristic of multi-target synergism. The raw materials in the formula are homologous in medicine and food, free of toxic and side effects, mild in medicine property and capable of considering fetal elements, the three medicines all belong to clinical common miscarriage prevention or miscarriage prevention categories, worries about blood breaking and fetal movement are avoided, and the traditional Chinese medicine is suitable for being used in the pregnancy stage. The pharmaceutical composition disclosed by the invention can be used for relieving clinical symptoms of hypertensive patients in pregnancy and improving the outcome of bad pregnancy.

Embodiments of the invention provide a solution for ameliorating microbiome effects on neurodevelopment by developing a probiotic composition for consumption by a female during gestation. In certain aspects the probiotic is a multi-strain probiotic cocktail consisting of immunomodulatory taxa and administered females during pregnancy and lactation.

The invention discloses a CHRM3 gene InDel molecular marker associated with growth and reproduction traits of a large white pig and application of the CHRM3 gene InDel molecular marker, a 62bp deletion variation is identified in a second intron of the CHRM3 gene, and a breakpoint is positioned in a second intron 521426525142713bp (a pig chromosome 14 reference sequence NC010456.5) of ENSSSCT00000082112.1. The application for detecting / identifying the growth and reproduction traits of the large white pigs is developed on the basis of the molecular marker, and the detection method is simple, rapid and low in cost and can be used for accurately screening individuals with better traits such as backfat thickness, primary birth litter weight, total multiparous litter size and gestation period of multiparous sows in the early stage, so that genetic improvement is carried out on the growth and reproduction traits of the pigs, and the economic benefit is increased. Multiple characters such as growth and reproduction can be selected at the same time, the breeding period of excellent boars can be shortened, and the breeding efficiency and progress are accelerated.

This invention discloses a method for establishing and validating a hydrogen peroxide-induced mouse autism model, relating to the field of medical biotechnology. The method for establishing the hydrogen peroxide-induced mouse autism model includes the following steps: injecting the hydrogen peroxide solution into the peritoneal cavity of pregnant mice to induce hydrogen peroxide, resulting in offspring mice with hydrogen peroxide induction, i.e., the mouse autism model. This invention uses near-peritoneal injection of hydrogen peroxide during the gestational period of the mother mouse, inducing oxidative stress in both the pregnant mother mouse and the offspring embryo through hydrogen peroxide alone, without causing a significant immune response in the mother mouse. Therefore, an oxidative stress-specifically induced ASD mouse model is formed. The resulting ASD offspring mice exhibit significant ASD phenotypes but do not show obvious motor impairment.

The invention relates to a method for detecting early embryo death of cattle and sheep, which is characterized by comprising the following steps of: 1) determining the detection time of early embryo death: when oestrus behavior characteristics of cows and ewes are observed by a pedometer or naked eyes, determining the time as the detection time; 2) detecting early embryo death: taking 5-10ml of cow and ewe blood, standing for 1-2 hours in a shade place, separating serum, respectively inserting bovine trophoderm protein-1 detection test paper and sheep trophoderm protein-1 detection test paper into the cow and ewe serum for 5-10 minutes, observing the detection test paper 15-18 minutes after the detection test paper is taken out, and when the detection test paper develops color, detecting the early embryo death; the cows or ewes are successfully fertilized and form early embryos, but still have estrus behavior characteristics, and the embryos are proved to be dead. Whether embryos die or not can be detected in time, the problems that the feeding cost is increased in the non-pregnant period, the number of fertilization opportunities caused by blind mating is small, and wombs of cattle and sheep are injured are solved, and by reasonably waiting for mating, the breeding efficiency is greatly improved, the yield of milk and goat milk is increased, and the income of a feeding farm is increased.

The invention discloses a preparation method and application of a corn germ meal extract, the preparation method is used for extracting functional active ingredients capable of improving heat stress resistance of rabbits from corn germ meal through a specific enzymolysis process, and the preparation method has the advantages of efficient extraction, condition optimization, cost effectiveness and the like; in the aspect of application, the extract can remarkably reduce the rectum temperature of rabbits, relieve the adverse effect of heat stress on rabbit bodies and enhance the adaptive capacity of rabbits in a high-temperature environment; meanwhile, the feed intake of the female rabbits in the gestation period and the lactation period is improved, so that the farrowing rate of the female rabbits is improved, and the number and quality of young rabbits are increased; in addition, the extract can also provide necessary nutritional support for growth and development of the young rabbits, promote rapid growth of the young rabbits, shorten the breeding cycle and improve the breeding benefits; moreover, the sperm quality, including sperm motility, ejaculation amount, malformation rate and other indexes, of the breeding male rabbits is remarkably improved, so that the fertilization success rate is improved, and the number and quality of young rabbits are increased.

The present invention relates to the medical and food use of bile acid derivatives. Specifically, the present invention relates to the use of 3-oxoLCA in reducing oxidative stress and inflammation in pregnant mothers and their offspring. Specifically, the present invention relates to the use of 3-oxoLCA to reverse the effects of oxidative stress on pregnant mothers, in particular, to maintain fetal equal weight, significantly reduce placental and liver oxidative stress in pregnant mothers and the resulting inflammation or dysfunction of the placenta and liver, and to improve the intestinal flora imbalance of pregnant mothers. Further studies have found that 3-oxoLCA has long-term effects, in particular, can significantly reduce the effects of oxidative stress during pregnancy on oxidative stress and inflammation in the liver of offspring.

The invention belongs to the technical field of medicines, and particularly relates to application of harpagide in preparation of a medicine for treating constipation. The technical problem to be solved by the invention is to provide a safer, milder and new effective choice for treating and relieving constipation. The technical scheme for solving the technical problem is to provide application of harpagide in preparation of drugs or health care products for treating or relieving constipation. The harpagide achieves or even exceeds the treatment effect of the fluid-increasing decoction compound. Meanwhile, in the small pigs, the constipation symptom of the small pigs in the gestation period is also obviously relieved. When the harpagide is used as a medicine for treating constipation, a safer, more efficient and standardized treatment effect can be achieved, a safer and milder treatment choice is provided for patients with constipation, and the harpagide has a very good application prospect.

The invention discloses a culture medium for goat trophoblast organoid, a culture method and application, and belongs to the field of goat trophoblast organoid culture. The method comprises the following steps: separating trophoblast tissues from a healthy goat placenta which is pregnant for 80-90 days, digesting the trophoblast tissues through type II collagenase to obtain primary cells, compounding the primary cells with matrigel, and performing three-dimensional culture in an improved trophoblast organ culture medium with specific components to form mature organs. The organ is of a typical three-dimensional structure, and KRT23 and SOX2 markers are stably expressed. The organoid culture system based on the goat primary trophoblast cells is established for the first time, gene modification is not needed, the in-vivo physiological status is highly simulated, and the culture system is standardized and good in repeatability. The constructed organoid can be used as an ideal in-vitro model for researching placenta development, evaluating drugs and toxins and modeling infectious diseases in the gestation period, and is of great significance in improving the reproductive research level of goats and the production benefits of animal husbandry.

The invention is applicable to the technical field of biological medicines, provides application of ophiopogon japonicus borneol glycoside in preparation of a medicine for preventing and treating gestational metabolic diseases, and aims to solve the technical problems that the conventional medicine is limited in use during pregnancy, and the curative effect and the safety are difficult to take into account. According to verification of multi-model systems such as animals, cells and human-derived trophoblast organs, it is found that ophiopogon japonicus borneol glycoside can significantly improve gestational glycometabolism disorder, improve insulin sensitivity and reduce insulin resistance, and therefore effective intervention on gestational diabetes mellitus is achieved. As a natural component derived from the Zhejiang radix ophiopogonis, the radix ophiopogonis borneol glycoside has definite pharmacological activity and excellent safety, and the Zhejiang radix ophiopogonis is listed in a national homology of medicine and food, so that reliable safety guarantee is provided for use during pregnancy.

The invention discloses an application of an RNAm6A modification level of PTGER4 in preparation of an ICP (inductively coupled plasma) auxiliary diagnosis kit. The RNA m6A modification level of the PTGER4 in placenta tissue and whole blood of an ICP patient is remarkably reduced, and the AUC modified by the RNA m6A of the PTGER4 in the whole blood is 0.844, so that the RNA m6A modification of the PTGER4 is a biomarker highly related to ICP attack, and a laboratory support can be provided for screening, diagnosis and treatment of ICP.

The application discloses a fetal cardiovascular physiological structure examination method and device, an ultrasonic equipment and a computer readable storage medium. The method comprises the following steps: determining a first measurement section and a first measurement item in the first measurement section of the fetal cardiovascular physiological structure examination; acquiring a gestation period parameter, determining a prediction model corresponding to the first measurement item and an evaluation model; wherein the gestation period parameter comprises any one or a combination of multiple of the following parameters: gestational age, biparietal diameter and femur long diameter; collecting the first measurement section, and determining an actual value of the first measurement item in the first measurement section; predicting a prediction value corresponding to the first measurement item based on the gestation period parameter by using the prediction model; calculating an evaluation value of the first measurement item based on the prediction value and the actual value by using the evaluation model, and obtaining an evaluation result of the first measurement item according to the evaluation value. The application meets the difference of different regions or different races, and improves the accuracy of the fetal cardiovascular physiological structure examination.

The invention belongs to the technical field of livestock breeding, and particularly relates to a bidding system for breeding living bodies in an incubation period according to adult value, which comprises a livestock breeding period model, an adult livestock model, a bidding and bidding module and a customer query module, and is characterized in that the livestock breeding period model and the adult livestock model are used for evaluating the value of livestock during slaughtering; the evaluated value and various breeding data are uploaded to a bidding module for customers to look up, various bidding rules are sent out, and finally bidding is carried out through a customer query module. According to the invention, the data model is established during the livestock breeding period, the model is used to deduce and evaluate the value of the livestock marketing data, bidding is carried out on the basis of the value evaluation, pre-selling is completed during the breeding period, the original selling time is prolonged to the whole breeding period, the selling pressure is reduced, and the marketing efficiency is improved. Meanwhile, the slaughtered livestock is prevented from occupying the farm, the next batch of livestock can be bred after slaughtering, and the economic benefit of livestock breeding is increased.

The application discloses a preparation method of self-assembled nanomedicine for improving fetal growth restriction and application thereof. Aspirin raw medicine, polyethyleneimine and phenyl borate are dissolved in dimethyl sulfoxide, and after being mixed uniformly, the mixture is placed into an ultrasonic cleaner until the medicine powder is completely dissolved, then the mixed solution is placed in a dialysis bag, and the organic solvent is removed by rotating dialysis in deionized water, finally, the solution in the dialysis bag is freeze-dried, and the self-assembled nanomedicine is obtained. The medicine is injected through a vein to improve the pathological pregnancy environment of hypoxia, oxidative stress and inflammation related to fetal growth restriction in a gestation period, and promote long-term growth and development of the development-restricted fetus. The self-assembling method is simple and easy to operate, low in price, and the organic solvent is easy to remove, and the stability is good and the immunogenicity is free. More importantly, under a treatment dose much higher than the treatment dose, the self-assembled nanomedicine has no toxicity to the mother and fetus, and the safety development of the fetus in the gestation period is ensured.

The invention discloses a feed additive composition for improving the farrowing rate of mice and the survival rate of young mice, feed and application of the feed, and belongs to the technical field of feed. The feed additive composition disclosed by the invention is prepared from the following components in parts by mass: 0.002 to 0.004 part of melatonin and 30 to 33 parts of shelled melon seed powder. When the composition disclosed by the invention is added into feed, anxiety and pressure of pregnant mice can be reduced, stress response can be relieved, and female mice can be kept quiet and mild; the problem of nutrition in the gestation period and the lactation period of female rats is solved, the baby eating and milk refusal conditions are reduced, and baby rats are not attacked; the litter number and the survival rate are improved, and the birth weight of the newborn rats is improved. And for transgenic rats with poor reproductive performance, the primary farrowing reproductive performance of the transgenic rats can be remarkably improved, the dystocia rate, the baby feeding rate and the milk rejection condition of female rats are reduced, and the survival rate of baby rats is improved.

The invention relates to an application of lactobacillus plantarum L168 in a medicine for improving inflammation level in a gestation period and resisting abortion caused by transitional immune stimulation, and belongs to the technical field of microorganism application, the lactobacillus plantarum L168 strain is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.13660. The lactobacillus plantarum L168 has the advantages that the lactobacillus plantarum L168 strain can be applied to preparation of medicines for improving inflammation level in the gestation period and resisting abortion caused by transitional immune stimulation, and the lactobacillus plantarum L168 strain can be applied to preparation of medicines for improving inflammation level in the gestation period and resisting abortion caused by transitional immune stimulation. The lactobacillus plantarum L168 disclosed by the invention can be used for effectively inhibiting excessive inflammatory response in a gestation period, reducing the risk of abortion caused by immunostimulation, improving a maternal immune microenvironment and promoting healthy development of a fetus, and is high in safety and easy to take as a natural probiotic preparation. The method can be widely applied to health management products in the gestation period, especially to adjuvant therapy and preventive intervention of high-risk pregnant women, and has important clinical and commercial values.

The method for predicting the severe brain injury probability of the newborn is used for predicting the severe brain injury probability of a selective fetal growth limited double-fetal newborn, and the selective fetal growth limited double-fetal newborn comprises a to-be-detected large fetus and a to-be-detected small fetus. The method comprises the following steps: acquiring a meconium sample of a large fetus to be detected and a meconium sample of a small fetus to be detected; the method comprises the following steps: pretreating and detecting a meconium sample of a large fetus to be detected and a meconium sample of a small fetus to be detected to obtain the concentration of marker metabolites in the meconium sample to be detected; according to the concentration of the marker metabolite of the big fetus and the concentration of the marker metabolite of the small fetus, the probability of severe brain injury of the big fetus and the small fetus is predicted; wherein the big fetus marker metabolite is different from the small fetus marker metabolite; according to the embodiment of the invention, the characteristic of recording the intrauterine metabolism state of the fetus in the whole gestation period by virtue of meconium is utilized, and the severe brain injury risk can be predicted in the early stage after birth. Different specific markers are screened for fetuses of different sizes, a prediction model is established, and the prediction result is accurate.

The invention relates to medical and food use of bile acid derivatives. Specifically, the invention relates to an application of 3-oxoLCA in reducing oxidative stress and inflammation of a pregnant maternal and offspring of the pregnant maternal. Specifically, the invention relates to the use of 3-oxoLCA to reverse the influence of oxidative stress on the pregnant maternal, in particular, to maintain the average weight of a fetus, to significantly reduce the oxidative stress of the placenta and liver of the pregnant maternal and the inflammation or dysfunction of the placenta and liver caused thereby, and to improve the intestinal flora imbalance of the pregnant maternal. Further research finds that the 3-oxoLCA has long-term influence, and particularly, the 3-oxoLCA can obviously reduce the influence of oxidative stress in the gestation period on the oxidative stress and inflammation of offspring liver.

The invention discloses application of indoleacetic acid in diagnosis and treatment of gestational diabetes mellitus. Clinical queue research finds that the concentration of serum indoleacetic acid of pregnant women in a gestational diabetes mellitus group is remarkably lower than that of pregnant women in a healthy control group, and high diagnosis efficiency is achieved. Animal experiments further prove that in a high fat diet induced mouse model with gestational diabetes mellitus, the exogenous indoleacetic acid is supplemented, so that the fasting blood glucose of a female mouse with gestational diabetes mellitus can be reduced, abnormal glucose tolerance and insulin resistance can be improved, and the indoleacetic acid is free of embryotoxicity, safe and reliable. The application provides a new thought and means for early diagnosis and effective treatment of gestational diabetes mellitus, and has a wide application prospect.

The utility model relates to the technical field of fetus protection bedding, in particular to a pregnant woman fetus protection bedding with an adjustable supporting angle, which comprises a backrest and an organ sleeve fixedly arranged below a back cushion, the organ sleeve is fixedly arranged on a base, a base support is arranged in the base, a backrest support is arranged in the backrest, and the back cushion is fixedly arranged on the base. The right side of the backrest support and the right side of the base support are connected to the main shaft through bearings, an air bag set is arranged in the organ sleeve and composed of a plurality of air bags, and air bag air inlets in the air bag set are uniformly arranged and fixed to an air inlet valve on the right side. Pressure borne by the waist and the back of the pregnant woman is gradually increased. The air cushion with the adjustable supporting angle can help the pregnant woman to find a supporting point most suitable for the pregnant woman, the pressure of the waist and the back is effectively relieved, and the proper backrest supporting angle can help the pregnant woman maintain good blood circulation.

A system, device, and method of controlling, supporting, and / or elongating the cervix uteri are provided to treat gestation complications and / or delay the onset of childbirth such that the gestation period of a fetus can be extended to prevent preterm birth and childbirth of the fetus. A cervical control system may include a body configured to be placed in the vagina. The body has an internal channel configured for receiving a cervix therein and an inflatable and / or inflatable inner cuff extending from a portion of the internal channel. The inner cuff may inflate inwardly toward the cervix, or downwardly away from the cervix, or both inwardly and downwardly, such that the inner cuff may engage or clamp the cervix to secure the cervix control system in place while pressing the cervix to close, elongate, and / or adjust the cervix orientation angle.

The invention relates to the technical field of medical detection, in particular to a biomarker composition for diagnosing gestational diabetes mellitus and application of the biomarker composition. The invention provides application of the combination of SHBG protein and Vaspin protein in preparation of a product for diagnosing gestational diabetes mellitus, when SHBG and Vaspin are jointly used for diagnosing gestational diabetes mellitus, extremely high diagnosis efficiency is achieved, the AUC value reaches 0.934, the accuracy is 0.91, the sensitivity is 0.872, and the specificity is 0.949, and by means of the biomarker combination, whether the risk of suffering from GDM exists or not can be diagnosed in an early stage, and if the risk of suffering from GDM exists or not, the risk of suffering from GDM in the early stage can be judged. A basis is provided for timely intervention, the complication risk of pregnant women and fetuses is reduced, and the health outcome of mothers and infants is improved.

The invention discloses an SNP (Single Nucleotide Polymorphism) genetic marker associated with the number of days in the gestation period of sows and application of the SNP genetic marker, and belongs to the technical field of pig genetic marker detection, the SNP genetic marker is located at a 26188159 bp nucleotide site of a No.7 chromosome of a reference sequence of an international pig genome version 11.1, the basic group of the site is C or T, and the SNP genetic marker is located at the upstream 373200 bp position of an MLIP gene. The invention also discloses an application of the SNP genetic marker in breeding sows with short gestation period days. The SNP genetic marker can be used for screening sows with short gestation period days, provides a new marker resource for auxiliary selection of breeding sows, and can be used for genetic breeding of the breeding sows.

The invention discloses a traditional Chinese medicine composition for preventing and treating pregnancy complications as well as a preparation method and application thereof. The composition is composed of medicinal and edible traditional Chinese medicines including radix rehmanniae recen, fructus gardeniae, gastrodia elata, fructus lycii and exocarpium citri rubrum, and mulberry leaves, ramulus uncariae cum uncis and the like can be selectively added. The preparation method comprises the steps of extracting volatile oil by steam distillation, leaching by a solvent, concentrating, mixing and the like, and can be combined with ultrasonic crushing to strengthen extraction. The composition is based on the treatment method of nourishing kidney, containing wood, clearing heat, calming liver, dissolving turbidity and preventing miscarriage in traditional Chinese medicine, has the effects of multi-target synergistic pressure reduction, proteinuria improvement and fetal development promotion aiming at the pathogenesis of yin deficiency and yang hyperactivity in the gestation period, is high in safety and free of fetal toxic and side effects, and is suitable for prevention and treatment of hypertensive diseases in the gestation period such as preeclampsia and the like.

The invention belongs to the technical field of medicine preparation, and particularly relates to application of propionic acid or salt thereof in preparation of a medicine for treating intrahepatic cholestasis in a gestation period. Experimental verification shows that propionic acid or salt thereof can significantly reduce the content of TBA, ALT, AST and ALP in serum of rats in a gestational intrahepatic cholestasis (ICP) model group, so that the content of TBA, ALT, AST and ALP approaches the content of serum of rats in a blank control group; in addition, propionic acid or its salt can significantly increase the weight of placenta and fetus of a gestational intrahepatic cholestasis (ICP) model group rat and reduce the fetal death rate, indicating that propionic acid or its salt can effectively treat the gestational intrahepatic cholestasis.

The application belongs to the field of pig marker-assisted selection technology, and particularly relates to application of a SNP molecular marker related to a pig gestation period trait. The SNP molecular marker is at a base at a 32922080 locus of a first chromosome in a pig genome Sscrofa11.1.109. The SNP locus of the molecular marker has C / G polymorphism, wherein C is a favorable allelic variation of the pig gestation period trait. The superior allele of the SNP can increase the frequency of the superior allele generation by generation, shorten the gestation period of the pig, and accelerate the genetic improvement progress of the pig, thereby effectively reducing the cost of breeding of a breeding pig.

The invention discloses an antioxidant drug delivery system with ROS (reactive oxygen species) targeted modification. The antioxidant drug delivery system comprises nanoparticles with a core-shell structure and fat-soluble drugs loaded in the nanoparticles, wherein glutathione is used as a shell, polyethyleneimine-polycaprolactone is used as a core, and the fat-soluble drugs are loaded in the nanoparticles. Oxidized PEI-PCL is connected and modified by adopting GSH through a disulfide bond, a delivery system which is formed by self-assembly and has a core-shell structure with GSH as a functional anti-oxidation shell and (oxi) PEI-PCL as a drug loading core to load a fat-soluble drug can be used for realizing specific drug delivery of cells in a placenta in treatment of gestational diseases, and the delivery system has a wide application prospect. Non-specific drug absorption of a maternal body and a fetus is effectively avoided, a relatively exact drug distribution effect and an in-vivo treatment effect are achieved, toxic and side effects on the maternal body and the fetus are remarkably reduced, and drug treatment of gestational diseases is facilitated.

The invention discloses an animal model construction method for fetal osteoporosis, a prevention and treatment target and application of the prevention and treatment target. The fetal osteoporosis animal model is a filial generation rat which is obtained after a pregnant female Wistar rat is subjected to intragastric administration of Acimoline (300 mg / kg. D) in the pregnancy period. Weaning is conducted four weeks after birth, male and female are separated from cages and fed to 12 weeks, the peak bone mass of female offspring is remarkably reduced, and therefore the animal model with exposed Acimoline during pregnancy is established. On the basis of a pregnancy-stage Acimoline exposed rat model, 20 mg / kg hippuric acid is intragastric injected in the pregnancy stage, and peak bone mass reduction of female offspring can be effectively corrected. The animal model established by the invention is novel, reliable, simple and convenient, and application of hippuric acid in screening and preparing medicines for preventing and treating fetal osteoporosis is determined.

The invention discloses application of icariin or icariin composition in preparation of a medicine for cross-generation improvement of fertility of male mammals, and belongs to the technical field of biological medicine. It is confirmed for the first time that when icariin is given to the parental generation in the gestation period, remarkable cross-generation protection and improvement effects can be generated on fertility of male offspring of the parental generation. The discovery surpasses the traditional cognitive framework that icariin is only used for treating contemporary individual sterility, and reveals a brand-new and proactive application value of icariin in the field of reproductive health. The invention provides a brand new active ingredient and an intervention strategy for preventing and treating cross-generation male reproduction injury caused by factors such as parental environment exposure and the like, and has important scientific value and clinical application prospect.