396 results about "Nanomedicine" patented technology

The invention discloses a drug-loaded liposome nano-particle, a preparation method thereof and application of the drug-loaded liposome nano-particle in treatment of brain glioma, and belongs to the technical field of biological nano-medicines. The invention provides a novel copper phthalocyanine derivative and catalase co-loaded lipidosome nanoparticle and application of the novel copper phthalocyanine derivative and catalase co-loaded lipidosome nanoparticle to treatment of brain glioma on the cellular level. The nano-particles are obtained by wrapping copper phthalocyanine derivatives and catalase with lipidosome prepared by a microfluidic method. The co-drug-loaded liposome can catalyze excessive H2O2 in brain glioma to generate oxygen, and O2 is continuously supplied to photodynamic therapy (PDT) to generate active oxygen; meanwhile, Cu < 2 + > can deplete glutathione and improve the oxidative stress level in the glioma, the reduction product Cu < + > can convert H2O2 into hydroxyl radicals with higher toxicity through a Fenton-like reaction, oxidative stress injury is doubly amplified, cascade cooperation of PDT and chemical dynamic therapy (CDT) is achieved, and the treatment effect on the glioma is remarkably enhanced.

The invention belongs to the cross technical field of nanomedicine, tumor treatment and immunotherapy, and particularly provides tumor mitochondria-targeted copper death selective induction nanoparticles, which are prepared by the following preparation method: S1, specifically coupling TPY and MHI through condensation reaction to obtain MTPY; s2, MTPY and copper ions are subjected to complexation, and an MTPY-Cu complex is obtained; and S3, the MTPY-Cu complex and albumin are subjected to self-assembly, and the MTPY-Cu-coated Alb nanoparticles are formed. The dosage of copper is only 1 / 1000 of that of free Cu < 2 + >, and equivalent immune regulation and killing effects can be achieved; primary tumors and distant tumor focuses can be inhibited, and lung metastasis is reduced; immune memory can be induced, and relapse can be prevented; the traditional Chinese medicine composition is combined with cis-platinum to remarkably enhance the curative effect and reverse the induced immunosuppression; the invention has the advantages of high biological safety and no obvious liver and kidney toxicity or hemolytic reaction.

The preparation method comprises the following steps: synthesizing gold nanostars (GNS) by using a seed growth method, coating mesoporous cerium dioxide (mCeO2) by using a template method, and loading a photosensitizer indocyanine green (ICG), so as to form a nano enzyme diagnosis and treatment system with chemical activity, photoactivity and photothermal effects. In the system, the gold nanostars have a good photo-thermal effect due to the multi-branched structure of the gold nanostars; on one hand, the mesoporous cerium dioxide coated on the outer layer has a chemical effect due to the nano-enzyme effect, and on the other hand, the mesoporous structure of the mesoporous cerium dioxide can better load the photosensitizer indocyanine green. All the components have good stability and biological safety, also have peroxidase simulation activity and a drug loading function, can improve the level of reactive oxygen species (ROS) in a tumor microenvironment and load photosensitizer drugs, and have an excellent anti-tumor effect and small side effects.

The invention discloses a multi-active targeting tumor nano-drug with a multimode imaging function and an immune activation effect and a preparation method thereof, and belongs to the technical field of nano-drugs. The preparation method comprises the following steps: coupling inorganic metal-based nano particles / nano drugs with a multimode imaging function or / and targeting active organic biomolecules with specific functions and specific therapeutic drugs through a silane cross-linking agent or a combination of the silane cross-linking agent and a carbodiimide condensing agent; the active targeting type organic-inorganic composite nano-drug aggregate with a multi-mode imaging function and an immune activation effect is prepared. Wherein the inorganic component is a metal-based heterostructure nanoparticle with a multimode imaging function, and the organic component is a bioactive molecule or / and a specific therapeutic drug. The obtained nano-drug aggregate is stable in system, uniform and controllable in size and good in biocompatibility, and has specific targeting, such as specific targeting liver cancer cells.

The embodiment of the invention provides breast cancer targeting nanoparticles as well as a preparation method and application thereof. According to the embodiment of the invention, the breast cancer targeting nanoparticles are synthesized by preparing the pH sensitive polymer, carrying out co-coupling modification on the pH response polymer and the folic acid albumin nano-carrier and utilizing a controlled desolvation method; the breast cancer targeting nanoparticle is combined with a nano preparation passive targeting strategy, a tumor microenvironment stimulation response strategy and a folic acid active targeting strategy, the effects of an EPR effect, PEG shedding, charge overturning, folic acid ligand-receptor combination and the like are utilized, precise targeting and specific response of tumors are achieved, and targeted accumulation of drugs in a tumor microenvironment is comprehensively improved. Therefore, the breast cancer targeting nanoparticles prepared by the embodiment have the advantages of high targeting property, drug controlled release, improvement of solubility and absorptivity of indissolvable drugs and the like, so that the curative effect of the drugs can be enhanced, the toxic and side effects can be reduced, and the breast cancer targeting nanoparticles have wide application prospects in the field of anti-tumor treatment.

The invention discloses a dual-targeting bionic liposome composite material and a preparation method and application thereof, and belongs to the technical field of nano-medices.The dual-targeting bionic liposome composite material is prepared by taking liposome nano-particles as a carrier, loading iloumab and alkannin on the carrier to obtain drug-loaded liposome, and fusing the drug-loaded liposome with a macrophage membrane to obtain the dual-targeting bionic liposome composite material. And modifying with phospholipidic hyaluronic acid to obtain the double-targeting bionic liposome composite material. According to the invention, two anti-atherosclerosis effects with different mechanisms, i.e., lipid lowering by Elolukumab and anti-inflammation by alkannin, are utilized to realize targeted therapy of atherosclerosis, and the bionic membrane on the outermost layer realizes long blood circulation and lesion site targeting ability of the composite material through inherent immune escape and recruitment characteristics of macrophages. The characteristic that hyaluronic acid interacts with a target cell surface receptor CD44 is utilized, effective utilization of the target cell on the composite material is achieved, and the atherosclerosis prevention and treatment effect of the composite material is improved.

The invention belongs to the field of nano-medicine and traditional Chinese medicine, and particularly discloses an antioxidant nano-material based on self-assembly of traditional Chinese medicine and copper ions and a preparation method thereof.The nano-material is prepared from BPCu nano-particles formed by self-assembly of berberine and procyanidine B2 under induction of the copper ions, the BPCu nano-particles are further subjected to surface modification through polyvinylpyrrolidone, and the antioxidant nano-material is prepared. And the stably dispersed PVP-coated BPCu nano structure is obtained. The material is small in particle size, uniform in distribution, good in water solubility and storage stability, excellent in free radical scavenging capacity and catalase-like activity and suitable for adjuvant therapy of oxidative stress related diseases, and the preparation method is easy and convenient to operate, does not need an organic solvent and has good industrialization and disease treatment potential.

The method of treating obesity and targeting adipose tissue in a patient may use injection of a polycationic polymer, such as polyamidoamine (PAMAM) generation 3 (P-G3) or a PCL-g-PAMAM Denpol, that when delivered intraperitoneally, selectively targets visceral adiposity due to its high charge density. P-G3 treatment of obese mice inhibits visceral adiposity, increases energy expenditure, prevents obesity, and alleviates associated metabolic dysfunctions. The extracellular matrix of adipose tissue is enriched with glycosaminoglycans, the known biomacromolecules with the strongest negative charge. P-G3 uncouples adipocyte lipid synthesis and storage from adipocyte development, creating adipocytes with normal functions but that are deficient in hypertrophic growth. The visceral fat distribution of P-G3 is further enhanced by modifying P-G3 with cholesterol to form lipophilic nanoparticles, effective in treating obesity. This strategy provides a method to target visceral adiposity, and cationic nanomaterials useful for treating metabolic diseases or for delivery of additional treating agents.

The invention belongs to the technical field of nano-drugs, and discloses a multifunctional nano-drug delivery system for treating neovascular eye diseases and a preparation method of the multifunctional nano-drug delivery system. The nano drug delivery system disclosed by the invention is a composite nano preparation which takes dendritic mesoporous silica nanoparticles as a carrier and co-loads cerium zirconium oxide nano enzyme and an anti-VEGF (vascular endothelial growth factor) drug, various active oxygen can be efficiently removed, oxygen is continuously released through catalytic decomposition of hydrogen peroxide, a retina hypoxia microenvironment is improved, and the retina hypoxia effect is improved. According to the present invention, the anti-VEGF drug delivery system can reduce the oxidative stress induced retinal pigment epithelial cell apoptosis rate, reduce the inflammatory reaction, and simultaneously achieve the slow release and the controlled release of the anti-VEGF drug, and the drug effect maintenance time can achieve more than 60 days, such that the multi-target synergistic treatment can be achieved through the synergistic regulation of the multiple pathological links such as oxygen deficit-oxidative stress-inflammation-angiogenesis, and the anti-VEGF drug delivery effect can be achieved. The choroidal neovascularization can be effectively inhibited by single intravitreal injection, and a new strategy of multi-target collaborative treatment is provided for neovascular macular degeneration and other eye diseases.

The invention discloses an anti-soybean mosaic virus nano medicament and a preparation method thereof. The anti-soybean mosaic virus nano medicament is synthesized from a xinjunan solution, SPc powder and a solvent, wherein the weight ratio of the SPc powder to the xinjunan solution is 1: (0.5-3.0); the solvent is clear water, purified water and deionized water. The invention relates to a self-assembled nano antiviral pesticide based on SPc and a broad-spectrum bactericide / antiviral agent xinjunan, which is used for preventing and treating SMV in the field. The SPc is self-assembled with the xinjunan through hydrogen bonds and Van der Waals force, the particle size of the xinjunan is remarkably reduced, the contact angle of the xinjunan on soybean leaf surfaces is reduced, the leaf surface retention is improved, and excellent wettability and adhesion performance are shown. Besides, the nano-agent obviously inhibits accumulation of viruses in soybean plants, so that the maturing rate of soybean fruits is increased, the mottle rate of seed coats is reduced, and the field control effect on SMV is greatly enhanced.

The invention discloses a tannic acid modified tungsten disulfide nanosheet and application thereof in treatment of acetaminophen acute liver injury, the nanosheet takes a tungsten disulfide nanosheet as a core, and the surface of the tungsten disulfide nanosheet is modified with electronegative tannic acid. The nanosheet disclosed by the invention has good stability and biocompatibility, can be used for preparing a nano-drug for treating acetaminophen acute liver injury, and specifically targets and removes active oxygen at a liver injury part through an electrostatic adsorption effect, so that inflammatory response is inhibited, and symptoms caused by the acute liver injury are effectively relieved.

The invention provides application of combined use of thymopentin, salinomycin and IR780 iodide in preparation of a medicine for treating and inhibiting tumor dryness. The invention also provides a pharmaceutical composition for inhibiting tumor dryness. The invention relates to an endoplasmic reticulum stress nano inducer (DTSS) based on salinomycin, which is used for synergistically inhibiting the dryness of cancer cells and effectively sensitizing cancer immunotherapy. The endoplasmic reticulum targeted phototherapy drug s-780 is prepared by coupling p-toluene sulfonamide and IR780 iodide (IR780), is assembled together with thymopentin and salinomycin, and is finally functionalized by biotin to obtain a delivery nano-platform (DTSS) at a specific site, so that systemic anti-tumor immune response can be effectively activated, metastasis and recurrence of cancers can be inhibited, and the application prospect is wide. And a promising solution is provided for sensitizing cancer immunotherapy by inhibiting cancer cell dryness.

The present invention discloses a fusion protein, a high-density lipoprotein containing the fusion protein, and a bionic nano-drug, as well as preparation and application thereof. The fusion protein comprises an alpha-helical amphipathic polypeptide and a neuron targeting peptide. The high-density lipoprotein containing the fusion protein is used as a bionic nano-carrier to achieve brain-targeted delivery of the drug through intravenous administration, which saves manpower, material resources and financial resources compared with in situ administration to the brain, and significantly improves patient compliance.

The invention relates to a compound shown in a general formula I or a stereoisomer, a solvate, a hydrate, a prodrug, a stable isotope derivative and a pharmaceutically acceptable salt thereof. The compound can be anchored to the surface of a living cell through a hydrophobic acting force between a hydrophobic tail chain and a cell membrane and a receptor-ligand acting force between a ligand branch chain and cell membrane protein, the anchoring efficiency is high, the anchoring stability is high, and the treatment effect of the living cell on diseases can be enhanced; meanwhile, a biological orthogonal group can be introduced into the surface of a cell, and the cell anchored by the compound can be coupled with a nano-drug, a protein drug or a fluorescent probe and the like through a biological orthogonal reaction, so that the treatment effect on diseases can be remarkably improved, and in-vivo and in-vitro tracing of living cells can be realized. The compound shown in the general formula I provides a new technical platform for cell-based immune combination therapy, and provides a new thought and a new medicine for cell therapy based on various diseases. # imgabs0 #

The invention relates to a water-soluble antioxidant nanosheet as well as a preparation method and application thereof in acute liver injury, and relates to the technical field of nano-drugs. The water-soluble antioxidant nanosheet disclosed by the invention is obtained by self-assembling two-dimensional transition metal disulfide and protein, and has proper size, good life compatibility and superstrong antioxidant activity. The water-soluble antioxidant nanosheet disclosed by the invention can be used for effectively treating acute liver injury induced by acetaminophen by inhibiting oxidative stress; damaged liver tissues can be effectively targeted, and a treatment effect is achieved; mitochondrial ROS level can be reduced, mitochondrial membrane potential can be recovered, and mitochondrial damage can be reduced; the level of inflammatory factors of the liver in the acute liver injury process can be remarkably reduced, infiltration of macrophages is reduced, and excessive inflammatory response of the liver is relieved. The preparation method of the water-soluble antioxidant nanosheet is a simple and green synthesis method, and raw materials are low in price and easy to obtain.

The application discloses a kind of neutrophil membrane fusion liposome biomimetic nanomedicine carrier and its preparation method and application, belong to medical field.The carrier includes liposome and the neutrophil membrane fused to liposome;Liposome raw materials include DOPE, DPPC and cholesterol, and mass ratio is 6:3:1 in turn;Liposome and membrane protein mass ratio is 1:1.The application establishes quantitative analysis strategy based on NanoFCM, can accurately evaluate the fusion efficiency and fusion uniformity of NM@lipos at single particle level.Based on DOPE, the hybridization efficiency of NM@lipos (D) reaches 92.0%, which is significantly higher than that of NM@lipos (L) based on lecithin (70.1%).In in vivo experiment, the tumor enrichment capacity of NM@lipos (D) is increased by 5.1 times compared with Lipos (D) in 24 hours, and shows significantly prolonged circulation time.

The invention belongs to the technical field of nano medicine, and particularly relates to a targeted nano drug delivery system based on bionic composite membrane modification and application of the targeted nano drug delivery system. The preparation method comprises the following steps: firstly, loading hydrophobic drugs astragaloside and atorvastatin in a phospholipid bilayer of a liposome to obtain a drug-loaded liposome, then mixing an erythrocyte membrane with a macrophage membrane to obtain a hybrid composite membrane, coating the drug-loaded liposome with the hybrid composite membrane to obtain a liposome-composite membrane, and preparing the drug-loaded liposome-composite membrane. Finally, hyaluronic acid is inserted into the outer layer of the liposome-composite membrane, and the targeted nano drug delivery system is obtained. Compared with treatment by singly using drugs, the targeted nano drug delivery system provided by the invention has a remarkable combined synergistic effect, and a feasible treatment strategy is provided for effectively treating atherosclerosis.

The invention belongs to the technical field of anti-cancer drugs, and particularly relates to a nano-drug, a preparation method and application thereof, and a chemotherapy-photodynamic combined diagnosis and treatment reagent. The nano-drug provided by the invention comprises a vitamin E polyethylene glycol succinate nano-micelle, and a lauric acid modified tetravalent platinum prodrug, a hydrophobic photosensitizer and an emulsifier which are coated in the vitamin E polyethylene glycol succinate nano-micelle. According to the invention, co-transportation of the cis-platinum prodrug and the photosensitizer can be realized; after the nano-drug provided by the invention is passively transported into tumor cells in a targeted manner through an EPR effect, the hydrophobic photosensitizer can increase the generation of singlet oxygen under the irradiation of red light and cooperates with a chemotherapy drug (tetravalent platinum) to act together, chemotherapy and photodynamic therapy are combined, drug resistance can be overcome, and a good treatment effect is achieved; in the treatment process, the dosage of chemotherapeutic drugs is remarkably reduced, and side effects are greatly reduced.

The invention discloses a preparation method and application of a nano-composite for improving the bioavailability of a fat-soluble active substance curcumin by using a triterpenoid active micromolecule co-assembly. The invention aims to provide a preparation process of nanoparticles capable of loading active substances such as curcumin by utilizing the assembly characteristic of triterpenoid micromolecules and screening the combination proportion of materials. The preparation method is simple, convenient and low in cost. The nano-particles prepared by the method are spherical, uniform in particle size, and good in stability, water solubility and antioxidant activity; and the drug loading capacity of the nanoparticles encapsulated with the curcumin is 20.42%. According to the invention, high loading capacity of nutrient substances in the nano drug loading system is realized, and the bioavailability of polyphenol nutrient substances is improved.

The invention discloses a ZIF-8 composite material loaded with SSZ and ICG as well as a preparation method and application thereof, and belongs to the field of nano medicine. The preparation method comprises the following steps: mixing salazosulfapyridine, indocyanine green and zinc nitrate hexahydrate to obtain a mixed solution; adding 2-methylimidazole into the mixed solution, and stirring to generate ZIF-8 nanoparticles loaded with salazosulfapyridine and indocyanine green; removing uncombined impurities in the ZIF-8 nano-particles by means of centrifugation and washing, so as to obtain the ZIF-8 composite material loaded with SSZ and ICG; in the ZIF-8 synthesis process, indocyanine green and salazosulfapyridine are entrapped at the same time through a co-dissolution method, and compared with traditional'post-loading 'or'multi-step entrapment', the technological process is greatly simplified, and the drug entrapment efficiency and structural stability are improved; meanwhile, the composite material has good biocompatibility and enhanced cytotoxicity in breast cancer cells, and a novel efficient strategy is provided for combined treatment of breast cancer.

The invention discloses a copper ion mediated bivalirudin self-assembled nano-drug and a preparation method and application thereof, and belongs to the field of biological medicines.The preparation method comprises the following steps that bivalirudin and targeting peptide cRGD are dissolved in an organic solvent, copper salt is dissolved in deionized water, the organic solution and an aqueous solution are mixed, the pH is adjusted to be faintly acid or neutral, and the copper ion mediated bivalirudin self-assembled nano-drug is obtained; and fully stirring and reacting to obtain a suspension, centrifuging to remove supernate, and freeze-drying to obtain the freeze-dried powder. On the basis of a metal coordination polypeptide self-assembly strategy, metal ions are introduced on the basis of traditional polypeptide self-assembly, special reaction performance is introduced through coordination of polypeptide functional groups and the metal ions to participate in regulation and control of the polypeptide self-assembly process, and thrombus targeting peptide is introduced on the basis to achieve precise drug delivery at the thrombus part.

The invention discloses a liver-targeted exosome polydopamine silicon nano drug delivery system as well as a preparation method and application thereof, and relates to the field of inflammatory microenvironment targeted controlled-release drug delivery. The system is composed of exosome, active oxygen response bond modified mesoporous silica, PDA and an anti-inflammatory drug, the water solubility of natural medicinal compounds such as TB can be remarkably improved, the bioavailability can be improved, the effects of in-vivo and in-vitro specific targeted inflammation sites and efficient liver protection and hepatitis treatment can be achieved, the biotoxicity of TB is remarkably reduced, and the application prospect is broad. The compound is expected to be applied to safe and efficient acute liver injury treatment and prevention of natural medicinal compounds such as TB, so that a nanotechnology delivery strategy is provided for clinical application of other natural product monomers; the invention has important fundamental research significance and pre-clinical application value in the fields of accurate treatment, prevention and health care of acute hepatitis and acute liver injury.

The invention belongs to the technical field of biological medicines, and discloses a cationic polymer targeted nano material modified siRNA (small interfering ribonucleic acid) nano-drug and application thereof. The siRNA nano-drug disclosed by the invention has the capability of effectively penetrating through the blood brain barrier and improving the brain tissue distribution of the siRNA drug.

The present invention discloses a sound-activated ferrocene-based semiconductor polymer nano-drug, its preparation method and application, belonging to the field of nano-medicine. First, a ferroptosis prodrug DHU-CBA7 based on ferrocene was synthesized, and then the photosensitizer PFODBT and the ferroptosis prodrug DHU-CBA7 were encapsulated in an amphiphilic polymer shell DSPE-PEG and a ROS-responsive shell DSPE-PEG-TK. After connecting the anti-PD-L1 antibody (aPD-L1) externally, the final product was obtained. The preparation process of this nano-immunodrug is simple and highly safe, and can effectively enhance the effect of tumor immunotherapy through a series of cascade reactions, and is highly effective in anti-tumor applications.

The application belongs to the technical field of nanomedicine, tumor treatment and immunotherapy, and specifically provides a copper death selective induction nanoparticle targeting tumor mitochondria, which is prepared by the following preparation method: S1, TPY is specifically coupled with MHI through a condensation reaction to obtain MTPY; S2, MTPY is complexed with copper ions to obtain an MTPY-Cu complex; and S3, the MTPY-Cu complex is self-assembled with albumin to form an MTPY-Cu@Alb nanoparticle. The copper dose of the application is only 1 / 1000 of that of free Cu 2+ , and the equivalent immune regulation and killing effects can be achieved; the primary tumor and distant tumor foci can be inhibited, and lung metastasis can be reduced; and the application can induce immune memory and prevent recurrence; the application is combined with cisplatin to significantly enhance the therapeutic effect and reverse the induced immunosuppression; and the application has high biological safety, and has no obvious hepatorenal toxicity or hemolytic reaction.

The invention discloses a method for preventing and treating myocardial hypertrophy through calcium steady-state regulation and control of cassia twig and liquorice decoction, and belongs to the technical field of traditional Chinese medicine pharmacy and nano medicine. The nano-system has a core-shell structure, and a core of the nano-system wraps monarch and minister effect components composed of cassia twig and licorice fat-soluble components and is composed of an ATP responsive polymer; a shell of the pH-responsive adjuvant drug delivery system wraps an adjuvant effect component group composed of liquorice water-soluble components, the pH-responsive adjuvant drug delivery system is composed of a pH-responsive polymer, the surface of the pH-responsive polymer is modified with AT1R targeting peptide, and a preparation method of the pH-responsive adjuvant drug delivery system comprises the following steps: respectively preparing MMG and AEG; two-step self-assembly is carried out through a microfluidic technology, and AEG is used as a molecular template in the second step to guide the shell polymer to coat the core. The nano system disclosed by the invention can actively target hypertrophic myocardial cells, preferentially release AEG in a focus subacid environment, and then release MMG in a high ATP environment in the cells, so that materialization of a monarch, minister, assistant and guide compatibility theory is realized, and the targeting property, bioavailability and synergistic treatment effect of drugs are remarkably improved.

The invention relates to an ultrasonic response bionic piezoelectric nano-drug for treating epilepsy as well as a preparation method and application of the ultrasonic response bionic piezoelectric nano-drug. The ultrasonic response bionic piezoelectric nano-drug comprises hafnium-based piezoelectric nano-particles UIO-66-NH2 etched by sulfuric acid, an anti-epileptic drug, a microglial cell membrane and transferrin receptor targeting peptide, wherein the anti-epileptic drug is loaded in hafnium-based piezoelectric nanoparticles etched by sulfuric acid to form a drug loading core; the microcolloid cell membrane coats the outer surface of the drug loading core; the transferrin receptor targeting peptide is connected to a microglial cell membrane. The ultrasonic response bionic piezoelectric nano-drug is high in brain entering efficiency, stable in drug release amount and clear in preparation method path, is suitable for targeted delivery of various anti-epileptic drugs and treatment and research of nervous system diseases such as epilepsy, can adopt an intravenous injection administration mode and non-invasive administration, can avoid injury caused by an operation, and has a good application prospect. The electrical stimulation is generated in vivo without implanting and taking out the electrode, so that secondary injury and infection are avoided.

This invention discloses a polyethylene glycol-modified magnesium boride nanosheet and its application in treating acute liver failure and hepatic encephalopathy caused by acetaminophen. The nanosheet uses magnesium boride nanosheets as a core, with polyethylene glycol modified on the surface to improve biocompatibility. The nanosheet of this invention exhibits good antioxidant properties and can be used to prepare nanomedicines for treating acute liver failure and / or hepatic encephalopathy caused by acetaminophen. It generates reducing hydrogen gas through a hydrolysis reaction, effectively scavenging reactive oxygen species at the site of liver failure, thereby inhibiting inflammatory responses and effectively alleviating symptoms caused by acute liver failure.

The present invention relates to the field of medical technology, and in particular to a self-assembled nano drug and a preparation method thereof and pharmaceutical application in cardiovascular and cerebrovascular diseases. The self-assembled nano drug comprises the following components: macitentan, a photosensitizer Ce6 and a divalent manganese ion. The present invention has the advantage of excellent anti-tumor effect.