253 results about "Acid sensitive" patented technology

A method of forming a pattern comprises diffusing an acid formed by irradiating a portion of a photosensitive layer, into an underlayer comprising an acid sensitive copolymer having acid decomposable groups and attachment groups covalently bonded to the surface of the substrate and/or forming an interpolymer crosslink. Diffusing comprises heating the underlayer and photosensitive layer. The acid sensitive group reacts with the diffused acid to form a polar region on the underlayer, with the shape of the pattern. The photosensitive layer is removed, forming a self-assembling layer comprising a block copolymer having a first block with an affinity for the polar region, and a second block having less affinity for the polar region. The first block forms a domain aligned to the polar region, and the second block forms another domain aligned to the first. Removing either domain exposes a portion of the underlayer.

The invention discloses an underground multi-stage intelligent high pressure gas pulse formation fracturing device and a method thereof, belongs to the technical field of fracturing completion of oil and gas wells, and particularly relates to two technical sachems of the device and the method. The method is used for fracturing the underground layer by the underground multi-stage intelligent high pressure gas pulse formation fracturing device. The device is controlled by each stage of intelligent pressure encoding detonator to gradually detonate by stages at proper time to generate a large amount of high pressure gas according to the set working mode, the dynamic high pressure pulse pressure is formed in the well or holes of a formation, the formation is fractured to form a plurality of cracks, and the permeability of fluid in the formation is increased, so the oil and gas are easily produced. The device and the method have the advantages that the cyclic multiple pressure pulses which are controlled at proper pressure can be generated, so the formation can generate the compression-expansion-compression alternating 'resonance', the cracks are promoted to effectively extend, and a new fracturing network is formed, so the permeability of the formation is improved; the pollution to the formation and environment in the fracturing process is avoided; the method is suitable for the water-sensitive and acid-sensitive formation; the construction cycle is short, the cost is low, the equipment is simple and convenient, and the limitation by terrain and water sources is avoided.

Fluorine-free photoacid generators and photoresist compositions containing fluorine-free photoacid generators are enabled as alternatives to PFOS/PFAS photoacid generator-containing photoresists. The photoacid generators are characterized by the presence of a fluorine-free aromatic sulfonate anionic component having one or more electron withdrawing groups. The photoacid generators preferably contain a fluorine-free onium cationic component, more preferably a sulfonium cationic component. The photoresist compositions preferably contain an acid sensitive imaging polymer having a lactone functionality. The compositions are especially useful for forming material patterns using 193 nm (ArF) imaging radiation.

The present invention is drawn to versatile ink-jet inks, ink-jet ink sets, and methods of printing images with improved quality when printed on both glossy coated media and on plain paper. In accordance with these embodiments, an ink-jet ink formulated for printing on plain paper and glossy coated media can comprise a liquid vehicle including water, an organic solvent, and an organic amine; and a polymer-encapsulated, acid-sensitive pigment colorant dispersed the liquid vehicle.

The invention relates to a multi-function nano prodrug system based on a dendrimer, which belongs to the technical field of biomedicines and nano medical science. The nano system comprises four function parts: an outermost layer RGD (arginyl-glycocoll-aspartate) cyclic peptide as an active targeting head group (1), a polyethylene glycol (PEG) hydrophilic chain segment (2) connected with the targeting head group and the dendrimer, an anti-tumour drug (3) connected with the dendrimer by an acid sensitive chemical bond and a dendrimer kernel (4). The general formula of the nano system is RGD-PEG-Dendrimer-DOX (doxorubicine), wherein the macromolecule attribute of a dendrimer vector makes a vector system passively target to tumor tissues through an EPR (Enhanced Permeability and retention) effect; the RGD cyclic peptide makes the vector system actively target to the tumor tissues through the interaction of a ligand and a receptor and promotes the endocytosis of the tumor tissues; the acid sensitive chemical bond ensures that a drug-carrying system is stable in systemic circulation and releases active drugs after arriving tumor positions and entering an acid organelle to perform the function of cytotoxicity.

The invention relates to an oral medicinal composition formulation for treating peptic ulcer. The composition comprises esomeprazole, antiacid sodium bicarbonate and a medicinally acceptable carrier, wherein the esomeprazole contains an acid-sensitive proton pump inhibitor; and the antiacid sodium bicarbonate can improve the stability of the proton pump inhibitor. The invention also relates to a preparation method of the medicinal composition. Two active ingredients are integrated into one fixed unit formulation, so that response is quick, a medicinal scheme is simplified in the process of treating the peptic ulcer, and the compliance of a patient is improved.

Acid-catalyzed positive resist compositions which are imageable with 193 nm radiation and/or possibly other radiation and are developable to form resist structures of improved development characteristics and improved etch resistance are enabled by the use of resist compositions containing imaging polymer component comprising an acid-sensitive polymer having a monomeric unit with a pendant group containing a remote acid labile moiety.

Acid-sensitive, developer-soluble bottom anti-reflective coating compositions are provided, along with methods of using such compositions and microelectronic structures formed thereof. The compositions preferably comprise a crosslinkable polymer dissolved or dispersed in a solvent system. The polymer preferably comprises recurring monomeric units having adamantyl groups. The compositions also preferably comprise a crosslinker, such as a vinyl ether crosslinking agent, dispersed or dissolved in the solvent system with the polymer. In some embodiments, the composition can also comprise a photoacid generator (PAG) and/or a quencher. The bottom anti-reflective coating compositions are thermally crosslinkable, but can be decrosslinked in the presence of an acid to be rendered developer soluble.

The invention relates to a dual sensitive amphiphilic triblock copolymer containing disulfide bond and acylhydrazone bond and a preparation method and an application of the dual sensitive amphiphilic triblock copolymer. A BAB type amphiphilic triblock copolymer consists of a hydrophobic polyester block A and a hydrophilia polyethylene glycol block B, wherein the block A is polyether containing active terminal amino group and disulfide bond; the block B is benzaldehyde ester of an ethylene glycol monomethyl ether or single terminated polyoxyethylene polypropylene oxide copolymer; the block A and the block B are connected through acid sensitive acylhydrazone bond generated from reaction of active terminal amino group and aldehyde group. The dual sensitive amphiphilic triblock copolymer is good in biocompatibility and biodegradability, can be formed into nanoparticles with oxidation reduction sensitivity and acid sensitivity in a water medium in a self-assembling manner, can wrap hydrophobic medicines to form nano medicine preparations, and can promote rapid release of medicines in tumor cells due to fracture of disulfide bond and acylhydrazone bond which are sensitive to oxidation reduction in a high concentration glutathione and acid micro environment in the tumor cells.

The present invention provides an acid sensitive doxorubicin prodrug based on polyethylene glycol, and a method and an application of the acid sensitive doxorubicin prodrug based on polyethylene glycol. The preparation method comprises: preparing a polyethylene glycol whose end contains an acid sensitive acetal group and a p-nitrophenyl ester azide group by a reaction of a polyethylene glycol whose double ends contain diazido ethyl diacetal groups with a p-nitro phenyl propargyl carbonate; preparing the acid sensitive doxorubicin prodrug based on the polyethylene glycol by the reaction of the prepared polyethylene glycol with doxorubicin hydrochloride. The acid sensitive and water soluble doxorubicin prodrug has good biocompatibility and acid sensitivity, thereby being used as a stimulation sensitive antineoplastic prodrug.

The invention discloses compound covalent hydrogel capable of being released according to requirements as well as a preparation method and application of the compound covalent hydrogel. The hydrogel is used for sterilizing based on the cooperation of a cationic high polymer and silver nanoparticles. The cationic high polymer is used as a template to synthesize the silver nanoparticles and then thesilver nanoparticles are subjected to covalent crosslinking with an oxidized polysaccharide high polymer through an acid-sensitive Schiff base bond; and under an acidic environment generated by bacterium infection, the Schiff base bond is broken, so that the cationic high polymer is released through gel degradation, and silver ions are generated by oxidization and are used for common sterilization. The invention further discloses in-vitro and in-vivo antibacterial application of the compound covalent hydrogel. The compound covalent hydrogel is simple to prepare and low in cost, and the cationic high polymer and nano-silver are combined to prepare the compound hydrogel. The gel prepared by the preparation method can be used for improving the antibacterial effect of the single cationic highpolymer gel, and an antibacterial spectrum of nano-silver gel can be expanded; and the toxic or side effect of the nano-silver is reduced and the synergistic effect of the cationic high polymer gel and the nano-silver gel is realized. The antibacterial effect of the hydrogel disclosed by the invention is better than that of various commercial antibacterial hydrogel in the market.

Stabilized transdermal acid sensitive drug formulations and their associated methods of production and use are described. The formulations containing acid sensitive drugs can also an acrylic adhesive, and a pharmaceutically acceptable base. The formulations can further contain other adhesives, permeation enhancers, and other stabilizing compounds such as free radical inhibitors.

The invention provides a mitochondria-targeting micelle drug delivery system capable of reversing drug resistance of tumor. The drug delivery system is a polymer micelle which is obtained through self assembly of a block copolymer folic acid-polyethylene glycol-polyaspartic acid, also a mitochondria-targeting doxorubicin-triphenylphosphine compound (TPP-DOX) is synthesized, and doxorubicin and doxorubicin-triphenylphosphine (DOX/TPP-DOX) are together wrapped in the polymer micelle, so that the drug delivery micelle is obtained. The drug delivery system is capable of giving play to active targeting effect and possesses acid-sensitive characteristic, is capable of simultaneously releasing doxorubicin in mitochondria and nucleus in a positioning way after entering a tumor cell, helps to enhance antitumor activity and reverse the drug resistance of tumor, and provides a new strategy for the dilemma that chemotherapeutics drugs easily generate drug resistance.

The invention discloses an acid sensitive polymer prodrug, nanoparticles of the prodrug and application of the nanoparticles. In the acid sensitive polymer prodrug, a polymer precursor is a vinyl ether-functionalized water-soluble A-B type two-block polymer; drug molecules are linked with the A-B type two-block polymer through an acetal bond; the acid sensitive polymer prodrug is self-assembled in water solution to form predrug micellar nanoparticles in which a polyethylene glycol hydrophilic chain segment serves as an outer surface and an anti-cancer drug bound to a polymer main chain through the acetal bond serves as a hydrophobic core. The pH sensitive prodrug and the nanoparticles of he prodrug are simple in preparation method, and good in tumor inhibitory effect; the nanoparticles also can efficiently encapsulate another hydrophobic anticancer drug; the kill capability to the cancer cell is enhanced; and the efficiency of endocytosis of the cell to the nanoparticles can be enhanced by coupling specific target molecules onto the surfaces of the nanoparticles. Thus, the inhibitory effect on the tumor cell is enhanced.

The invention discloses an amphiphilic acid-sensitive ternary molecular brush polymer constructed acid-sensitive nanocapsule of which the general formula is disclosed in the specification, wherein A is a polymer main chain, B is a lipophilic high-polymer side chain, C is an acid-sensitive high-polymer side chain, D is a hydrophilic high-polymer side chain, and the side chains B, C and D are randomly grafted on the main chain A; and the amphiphilic acid-sensitive ternary molecular brush polymer is dispersed in an oil/water two-phase system to form the stable acid-sensitive nanocapsules. The invention solves the problem that the traditional intelligent nanocapsule can not easily and effectively regulate the substance release rate; the emulsion self-assembly process for preparing the nanocapsule is simple to operate, and can easily implement large-scale preparation; and the prepared hollow acid-sensitive nanocapsule has high coating capacity. A-g-(B-r-C-r-D).

The invention discloses dexlansoprazole enteric-coated slow controlled-release pellet tablets belonging to the field of slow controlled-release preparations, and in particular relates to a preparation method of acid-sensitive proton pump inhibitor (PPI) slow controlled-release pellet tablets. The pellet tablets are prepared by tabletting and coating two types of pellets with different release speeds as well as a filler, a disintegrating agent and a lubricant, and release active ingredients at different release speeds, wherein one type of the pellets are enteric-coated quick-release pellets, and the other type of the pellets are enteric-coated slow-release pellets.