258 results about "Acid sensitive" patented technology

A composition used to form an acid sensitive +E,uns a+EE nti+E,uns r+EE eflective +E,uns c+EE oating (ARC) includes a water soluble resin and a cross-linker. Radiation adsorptive components may be provided as part of the resin or, more preferably, as a separate dye. The composition may be applied on a substrate as a radiation adsorbing layer and additionally cross-linked to form an acid sensitive, water insoluble ARC on which a +E,uns p+EE hoto+E,uns p+EE atterning +E,uns r+EE esist (PPR) layer may be formed. Being acid sensitive, selected portions of an ARC formed from the composition may be removed by a suitable reversal of the cross-linking followed by a develop step, preferably with an aqueous developer, more preferably de-ionized water. The water soluble resin is preferably hydroxystyrene-sulfonated styrene copolymer, poly(2-isopropenyl-2-oxazoline), or poly(acrylic acid), the cross-linker is preferably an acetal diacid or a water soluble divinyl ether, and the dye is preferably 9-anthracene methanol or a squaric acid derivative. If a suitable +E,uns p+EE hoto+E,uns a+EE cid +E,uns g+EE enerator (PAG) is included then an ARC formed from such components may exhibit a photosensitivity similar to or even lower than that of the overlying PPR. The photosensitivity is preferably less than about 900 mJ / cm2, more preferably 100 mJ / cm2 or less.

A solid rapidly gelling oral pharmaceutical dosage form, as well as aqueous suspensions prepared thereof, comprising an acid sensitive proton pump inhibitor as active ingredient distributed in a multitude of enteric coated pellets and a suspension modifying granulate comprising a rapidly dissolving diluent granulated together with a gelling agent chosen among xanthan gums, and an acidic pH-regulating agent and a binder. The suspension modifying granulate is rapidly disintegrating and gelling when suspended in an aqueous medium and thus forming a homogenous stable and robust suspension having a reproducible and stable viscosity. Furthermore the invention relates to an improved process for its manufacture and the use of such formulation in medical treatment including prevention of gastrointestinal disorders in humans.

A composition used to form an acid sensitive antireflective coating (ARC) includes a water soluble resin and a cross-linker. Radiation adsorptive components may be provided as part of the resin or, more preferably, as a separate dye. Being acid sensitive, selected portions of an ARC formed from the composition may be removed by a suitable reversal of the cross-linking followed by a develop step, preferably with an aqueous developer, more preferably de-ionized water. The water soluble resin is preferably hydroxystyrene-sulfonated styrene copolymer, poly(2-isopropenyl-2-oxazoline), or poly(acrylic acid), the cross-inker is preferably an acetal diacid or a water soluble divinyl ether, and the dye is preferably 9-anthracene methanol or a squaric acid derivative.

The present invention relates to ultra-large scale integrated (ULSI) interconnect structures, and more particularly to patternable low dielectric constant (low-k) materials suitable for use in ULSI interconnect structures. The patternable low-k dielectrics disclosed herein are functionalized polymers that having one or more acid-sensitive imageable functional groups.

A method of forming a pattern comprises diffusing an acid formed by irradiating a portion of a photosensitive layer, into an underlayer comprising an acid sensitive copolymer having acid decomposable groups and attachment groups covalently bonded to the surface of the substrate and / or forming an interpolymer crosslink. Diffusing comprises heating the underlayer and photosensitive layer. The acid sensitive group reacts with the diffused acid to form a polar region on the underlayer, with the shape of the pattern. The photosensitive layer is removed, forming a self-assembling layer comprising a block copolymer having a first block with an affinity for the polar region, and a second block having less affinity for the polar region. The first block forms a domain aligned to the polar region, and the second block forms another domain aligned to the first. Removing either domain exposes a portion of the underlayer.

The invention discloses an underground multi-stage intelligent high pressure gas pulse formation fracturing device and a method thereof, belongs to the technical field of fracturing completion of oil and gas wells, and particularly relates to two technical sachems of the device and the method. The method is used for fracturing the underground layer by the underground multi-stage intelligent high pressure gas pulse formation fracturing device. The device is controlled by each stage of intelligent pressure encoding detonator to gradually detonate by stages at proper time to generate a large amount of high pressure gas according to the set working mode, the dynamic high pressure pulse pressure is formed in the well or holes of a formation, the formation is fractured to form a plurality of cracks, and the permeability of fluid in the formation is increased, so the oil and gas are easily produced. The device and the method have the advantages that the cyclic multiple pressure pulses which are controlled at proper pressure can be generated, so the formation can generate the compression-expansion-compression alternating 'resonance', the cracks are promoted to effectively extend, and a new fracturing network is formed, so the permeability of the formation is improved; the pollution to the formation and environment in the fracturing process is avoided; the method is suitable for the water-sensitive and acid-sensitive formation; the construction cycle is short, the cost is low, the equipment is simple and convenient, and the limitation by terrain and water sources is avoided.

A method of forming a pattern comprises diffusing an acid, generated by irradiating a portion of a photosensitive layer, into an underlayer comprising an acid sensitive copolymer comprising an acid decomposable group and an attachment group, to form an interpolymer crosslink and / or covalently bonded to the surface of the substrate. Diffusing comprises heating the underlayer and photosensitive layer. The acid sensitive group reacts with the diffused acid to form a polar region at the surface, in the shape of the pattern. The photosensitive layer is removed to forming a self-assembling layer comprising a block copolymer having a block with an affinity for the polar region, and a block having less affinity than the first. The first block forms a domain aligned to the polar region, and the second block forms a domain aligned to the first. Removing either the first or second domain exposes a portion of the underlayer.

Fluorine-free photoacid generators and photoresist compositions containing fluorine-free photoacid generators are enabled as alternatives to PFOS / PFAS photoacid generator-containing photoresists. The photoacid generators are characterized by the presence of a fluorine-free aromatic sulfonate anionic component having one or more electron withdrawing groups. The photoacid generators preferably contain a fluorine-free onium cationic component, more preferably a sulfonium cationic component. The photoresist compositions preferably contain an acid sensitive imaging polymer having a lactone functionality. The compositions are especially useful for forming material patterns using 193 nm (ArF) imaging radiation.

The invention belongs to the technical field of biomedical nanomaterials, and discloses a pH-responsive schiff base copolymer-coated mesoporous silica drug-loaded nanoparticle as well as a preparationmethod and application thereof. The nanoparticle provided by the invention comprises a mesoporous silica nanoparticle, a drug loaded inside the mesoporous silica nanoparticle, and a polymer modifiedon a surface of the mesoporous silica nanoparticle; and the polymer modified on a surface of the mesoporous silica nanoparticle is specifically P (PEGMA-co-MAEBA) modified on the surface of the mesoporous silica nanoparticle by an imine bond. The nanoparticle material provided by the invention has good biocompatibility, and realizes controlled release of the drug by utilizing an acid-sensitive imine bond; the drug is hardly released around normal cells, but the imine bond is broken in a slightly acidic environment of tumor cells, and the polymer falls off to rapidly release the drug, thereby realizing targeted therapy for the tumors; and the nanoparticle material is applicable to the field of controlled release of drugs.

The present invention is drawn to versatile ink-jet inks, ink-jet ink sets, and methods of printing images with improved quality when printed on both glossy coated media and on plain paper. In accordance with these embodiments, an ink-jet ink formulated for printing on plain paper and glossy coated media can comprise a liquid vehicle including water, an organic solvent, and an organic amine; and a polymer-encapsulated, acid-sensitive pigment colorant dispersed the liquid vehicle.

The invention relates to a multi-function nano prodrug system based on a dendrimer, which belongs to the technical field of biomedicines and nano medical science. The nano system comprises four function parts: an outermost layer RGD (arginyl-glycocoll-aspartate) cyclic peptide as an active targeting head group (1), a polyethylene glycol (PEG) hydrophilic chain segment (2) connected with the targeting head group and the dendrimer, an anti-tumour drug (3) connected with the dendrimer by an acid sensitive chemical bond and a dendrimer kernel (4). The general formula of the nano system is RGD-PEG-Dendrimer-DOX (doxorubicine), wherein the macromolecule attribute of a dendrimer vector makes a vector system passively target to tumor tissues through an EPR (Enhanced Permeability and retention) effect; the RGD cyclic peptide makes the vector system actively target to the tumor tissues through the interaction of a ligand and a receptor and promotes the endocytosis of the tumor tissues; the acid sensitive chemical bond ensures that a drug-carrying system is stable in systemic circulation and releases active drugs after arriving tumor positions and entering an acid organelle to perform the function of cytotoxicity.

Pharmaceutical compositions comprised of low-solubility and / or acid-sensitive drugs and neutralized acidic polymers are disclosed.

The present invention provides visible light sensitive and ultraviolet (UV) light sensitive composition for DNA transfer comprising acid sensitive polyacetals developed as DNA / RNA delivery agents, a photoacid generator and optionally a photosensitizer.

The photoresist resin composition comprises a polymer containing an acid-responsive compound unit of the following formula (e.g. an adamantane skeleton) and a photoactive acid precursor. R<1 >may be an alkyl group having a tertiary carbon atom in the 1-position and the Z ring is a bridged-ring hydrocarbon ring comprising 2 to 4 rings. wherein R<1 >and R<2 >are the same or different from each other and each represents a hydrogen atom, an alkyl group or a cycloalkyl group; R<3 >represents a hydrogen atom or a methyl group; R<4 >represents a hydrogen atom, a halogen atom, an alkyl group, an oxygen-containing group, an amino group or an N-substituted amino group; the Z ring represents a monocyclic or polycyclic alicyclic hydrocarbon ring; n represents an integer of not less than 1; with proviso that R<4 >does not concurrently represent a hydrogen atom, and may be different over n occurrences; in formula (1), R<1 >and R<2 >may, jointly and together with the adjacent carbon atom, form an alicyclic hydrocarbon ring. The above photoresist resin composition is high in etching resistance, can be solubilized by irradiation, and is capable of providing a finer line pattern.

The invention relates to an oral medicinal composition formulation for treating peptic ulcer. The composition comprises esomeprazole, antiacid sodium bicarbonate and a medicinally acceptable carrier, wherein the esomeprazole contains an acid-sensitive proton pump inhibitor; and the antiacid sodium bicarbonate can improve the stability of the proton pump inhibitor. The invention also relates to a preparation method of the medicinal composition. Two active ingredients are integrated into one fixed unit formulation, so that response is quick, a medicinal scheme is simplified in the process of treating the peptic ulcer, and the compliance of a patient is improved.

Acid-catalyzed positive resist compositions which are imageable with 193 nm radiation and / or possibly other radiation and are developable to form resist structures of improved development characteristics and improved etch resistance are enabled by the use of resist compositions containing imaging polymer component comprising an acid-sensitive polymer having a monomeric unit with a pendant group containing a remote acid labile moiety.

The invention provides for the first time an oral liquid composition of duloxetine or its pharmaceutically equivalent derivatives like salts, isomers, complexes, polymorphs, hydrates or esters thereof. The duloxetine or its pharmaceutically equivalent derivative is present from about 2 mg to approximately 200 mg; and a buffering agent was used to stabilize the acid sensitive duloxetine. The composition has duloxetine from about 0.1 meq to about 2.5 mEq per mg of duloxetine. The invention further discloses an oral liquid composition of duloxetine or its pharmaceutically equivalent derivative wherein the degradation product 1-Naphthol is less than 0.01%. Also provided is a method for treating of major depressive disorder and or diabetic peripheral neuropathic pain comprising administering to a mammal in need of such treatment a therapeutically effective amount of a composition.

In one aspect, pharmaceutical compositions comprising dispersions of an acid-sensitive drug and a neutral dispersion polymer are disclosed. The acid-sensitive drug has improved chemical stability relative to dispersions of the drug and acidic polymers. In another aspect, pharmaceutical compositions of low-solubility drugs and amphiphilic, hydroxy-functional vinyl copolymers are disclosed.

Acid-sensitive, developer-soluble bottom anti-reflective coating compositions are provided, along with methods of using such compositions and microelectronic structures formed thereof. The compositions preferably comprise a crosslinkable polymer dissolved or dispersed in a solvent system. The polymer preferably comprises recurring monomeric units having adamantyl groups. The compositions also preferably comprise a crosslinker, such as a vinyl ether crosslinking agent, dispersed or dissolved in the solvent system with the polymer. In some embodiments, the composition can also comprise a photoacid generator (PAG) and / or a quencher. The bottom anti-reflective coating compositions are thermally crosslinkable, but can be decrosslinked in the presence of an acid to be rendered developer soluble.

The invention relates to a dual sensitive amphiphilic triblock copolymer containing disulfide bond and acylhydrazone bond and a preparation method and an application of the dual sensitive amphiphilic triblock copolymer. A BAB type amphiphilic triblock copolymer consists of a hydrophobic polyester block A and a hydrophilia polyethylene glycol block B, wherein the block A is polyether containing active terminal amino group and disulfide bond; the block B is benzaldehyde ester of an ethylene glycol monomethyl ether or single terminated polyoxyethylene polypropylene oxide copolymer; the block A and the block B are connected through acid sensitive acylhydrazone bond generated from reaction of active terminal amino group and aldehyde group. The dual sensitive amphiphilic triblock copolymer is good in biocompatibility and biodegradability, can be formed into nanoparticles with oxidation reduction sensitivity and acid sensitivity in a water medium in a self-assembling manner, can wrap hydrophobic medicines to form nano medicine preparations, and can promote rapid release of medicines in tumor cells due to fracture of disulfide bond and acylhydrazone bond which are sensitive to oxidation reduction in a high concentration glutathione and acid micro environment in the tumor cells.

The present invention provides an acid sensitive doxorubicin prodrug based on polyethylene glycol, and a method and an application of the acid sensitive doxorubicin prodrug based on polyethylene glycol. The preparation method comprises: preparing a polyethylene glycol whose end contains an acid sensitive acetal group and a p-nitrophenyl ester azide group by a reaction of a polyethylene glycol whose double ends contain diazido ethyl diacetal groups with a p-nitro phenyl propargyl carbonate; preparing the acid sensitive doxorubicin prodrug based on the polyethylene glycol by the reaction of the prepared polyethylene glycol with doxorubicin hydrochloride. The acid sensitive and water soluble doxorubicin prodrug has good biocompatibility and acid sensitivity, thereby being used as a stimulation sensitive antineoplastic prodrug.

The invention discloses compound covalent hydrogel capable of being released according to requirements as well as a preparation method and application of the compound covalent hydrogel. The hydrogel is used for sterilizing based on the cooperation of a cationic high polymer and silver nanoparticles. The cationic high polymer is used as a template to synthesize the silver nanoparticles and then thesilver nanoparticles are subjected to covalent crosslinking with an oxidized polysaccharide high polymer through an acid-sensitive Schiff base bond; and under an acidic environment generated by bacterium infection, the Schiff base bond is broken, so that the cationic high polymer is released through gel degradation, and silver ions are generated by oxidization and are used for common sterilization. The invention further discloses in-vitro and in-vivo antibacterial application of the compound covalent hydrogel. The compound covalent hydrogel is simple to prepare and low in cost, and the cationic high polymer and nano-silver are combined to prepare the compound hydrogel. The gel prepared by the preparation method can be used for improving the antibacterial effect of the single cationic highpolymer gel, and an antibacterial spectrum of nano-silver gel can be expanded; and the toxic or side effect of the nano-silver is reduced and the synergistic effect of the cationic high polymer gel and the nano-silver gel is realized. The antibacterial effect of the hydrogel disclosed by the invention is better than that of various commercial antibacterial hydrogel in the market.

Stabilized transdermal acid sensitive drug formulations and their associated methods of production and use are described. The formulations containing acid sensitive drugs can also an acrylic adhesive, and a pharmaceutically acceptable base. The formulations can further contain other adhesives, permeation enhancers, and other stabilizing compounds such as free radical inhibitors.

The invention provides a mitochondria-targeting micelle drug delivery system capable of reversing drug resistance of tumor. The drug delivery system is a polymer micelle which is obtained through self assembly of a block copolymer folic acid-polyethylene glycol-polyaspartic acid, also a mitochondria-targeting doxorubicin-triphenylphosphine compound (TPP-DOX) is synthesized, and doxorubicin and doxorubicin-triphenylphosphine (DOX / TPP-DOX) are together wrapped in the polymer micelle, so that the drug delivery micelle is obtained. The drug delivery system is capable of giving play to active targeting effect and possesses acid-sensitive characteristic, is capable of simultaneously releasing doxorubicin in mitochondria and nucleus in a positioning way after entering a tumor cell, helps to enhance antitumor activity and reverse the drug resistance of tumor, and provides a new strategy for the dilemma that chemotherapeutics drugs easily generate drug resistance.

A polymer comprises an acetal-containing monomer unit having the general structure I and at least one of the fluorine-containing monomer units having the general structures II and III:wherein R<1>, R<4>, R<5 >and R<6 >are each independently H, lower alkyl, CH2CO2R<10>, cyano, CH2CN, or halogen, wherein R<10 >is any alkyl, cycloalkyl, aryl, arylalkyl, alkylenecycloalkyl, silyl or siloxy or linear or cyclic polysiloxane group; R<2 >is CHR<11>R<12 >where R<11 >and R<12 >are each independently H, lower alkyl, cycloalkyl or aryl; A is a substituted or unsubstituted alkylene, cycloalkylene, alkylenecycloalkylene, or alkylenearylene; and R<3 >is linear, branched or cyclic fluoroalkyl group or SiR<13>R<14>R<15 >where R<13>, R<14>, and R<15 >are each independently alkyl, cycloalkyl, aryl, arylalkyl, alkylenecycloalkyl, silyl, siloxy, linear or cyclic polysiloxane or silsesquioxane alkyl group; B is an aryl, C(=O)-O-(CH2)x where x=0-4, lower alkyl, cycloalkyl, alkene cycloalkyl, silyl, siloxyl, or linear or cyclic polysiloxane group. R<7 >is H or an acid sensitive group; R<8 >and R<9 >are each independently H or -CN group; and y=0-4 and the use of these polymers in radiation sensitive compositions for exposure to actinic radiation, especially radiation of 157 nm.

The invention discloses an acid sensitive polymer prodrug, nanoparticles of the prodrug and application of the nanoparticles. In the acid sensitive polymer prodrug, a polymer precursor is a vinyl ether-functionalized water-soluble A-B type two-block polymer; drug molecules are linked with the A-B type two-block polymer through an acetal bond; the acid sensitive polymer prodrug is self-assembled in water solution to form predrug micellar nanoparticles in which a polyethylene glycol hydrophilic chain segment serves as an outer surface and an anti-cancer drug bound to a polymer main chain through the acetal bond serves as a hydrophobic core. The pH sensitive prodrug and the nanoparticles of he prodrug are simple in preparation method, and good in tumor inhibitory effect; the nanoparticles also can efficiently encapsulate another hydrophobic anticancer drug; the kill capability to the cancer cell is enhanced; and the efficiency of endocytosis of the cell to the nanoparticles can be enhanced by coupling specific target molecules onto the surfaces of the nanoparticles. Thus, the inhibitory effect on the tumor cell is enhanced.

The invention discloses an amphiphilic acid-sensitive ternary molecular brush polymer constructed acid-sensitive nanocapsule of which the general formula is disclosed in the specification, wherein A is a polymer main chain, B is a lipophilic high-polymer side chain, C is an acid-sensitive high-polymer side chain, D is a hydrophilic high-polymer side chain, and the side chains B, C and D are randomly grafted on the main chain A; and the amphiphilic acid-sensitive ternary molecular brush polymer is dispersed in an oil / water two-phase system to form the stable acid-sensitive nanocapsules. The invention solves the problem that the traditional intelligent nanocapsule can not easily and effectively regulate the substance release rate; the emulsion self-assembly process for preparing the nanocapsule is simple to operate, and can easily implement large-scale preparation; and the prepared hollow acid-sensitive nanocapsule has high coating capacity. A-g-(B-r-C-r-D).

The invention discloses an acid-sensitive degradable polymer vesicle and preparation and application of the polymer vesicle. The polymer vesicle is formed by an A-B-C type block polymer, wherein the block A is polyethylene glycol and distributed on the external surface of the vesicle; the block B is hydrophobic pH-sensitive degradable polymer poly(trimethoxy benzaldehyde acetal-trimethylolethane-methacrylate) and forms a film core of the vesicle; and the block C is polyelectrolyte selected from one of polyacrylic acid, polymethacrylic acid, dimethylaminoethyl polymethacrylate, diethylaminoethyl polymethacrylate and diisopropylaminoethyl polymethacrylate, distributed on the inner wall of the vesicle film, and used for efficiently loading medicaments with opposite charges. The pH-sensitive degradable vesicle is simple in preparation method, can efficiently load micromolecular hydrophile anticancer medicaments, therapeutic protein medicaments, polypeptide medicaments and nucleic acid medicaments.

The invention discloses dexlansoprazole enteric-coated slow controlled-release pellet tablets belonging to the field of slow controlled-release preparations, and in particular relates to a preparation method of acid-sensitive proton pump inhibitor (PPI) slow controlled-release pellet tablets. The pellet tablets are prepared by tabletting and coating two types of pellets with different release speeds as well as a filler, a disintegrating agent and a lubricant, and release active ingredients at different release speeds, wherein one type of the pellets are enteric-coated quick-release pellets, and the other type of the pellets are enteric-coated slow-release pellets.

The invention belongs to the field of polymer modification, and particularly relates to an acid-sensitive hydrophobic modified polyethyleneimine and application thereof as a gene vector. The derivative contains an acid-sensitive acetal functional group; and specifically, the derivative is an acetal-molecular trimethoxy benzylacetal-trihydroxy ethylacetal (TMB-THME) modified polyethyleneimine derivative, named polyethyleneimine-(trimethoxy benzylacetal-trihydroxy ethane). The polyethyleneimine-(trimethoxy benzylacetal-trihydroxy ethane) provided by the invention enhances the DNA (deoxyribonucleic acid) compounding capability of PEI (polyetherimide) and the interaction with cells, can convert a hydrophobic group into a hydrophilic group in an endosome, and implements the dissociation of theDNA compound and the intracellular release of the DNA; and the cytotoxicity is low.