The invention discloses a comprehensive improvement method suitable for inland extreme arid area saline-alkali soil. The method is formed by integrating multiple technological innovations of levellingsoil and eliminating salt accumulation in surface soil, returning straw to field and improving a soil body structure so as to block a salinity ascending channel, additionally applying an organic fertilizer and optimizing fertilized soil to improve a crop saline-alkaline tolerance capacity, deep-plowing soil and adjusting grain compositions so as to retard salinity ascending, additionally applyingan improver and creating a low-salt rhizosphere micro-environment, covering by straw and preventing soil salt return, rationally irrigating for salt-leaching and desalting and the like. The technology can be applied for performing straw simplification on preceding crops and rapidly and directly returning to the field, relieving labor intensity of a farmer, adequately using straw nutrient resources for usage by crops in the next season, reducing an applying quantity of a chemical fertilizer, and reducing agricultural production cost. An isolating layer is formed in a soil body, so the ascending of underground water and salinity in the lower soil body is retarded, and the salt accumulation in the surface soil and the salt return are reduced. The method has multiple functions of improving the saline-alkali soil, improving production capacity of cultivated land, increasing production, saving cost and increasing income and the like, and is remarkable in economic, social and ecological environment benefits.