575 results about "Micro environment" patented technology

A retail store has responsive environment apparatus installed which is controlled by processing apparatus. Trigger event sensors coupled to the processing apparatus, are positioned throughout the store. When customers enter and move about the store, the processing apparatus senses various trigger events and in response thereto creates a micro-environment in the vicinity of each customer, catering to the characteristics of that customer. The micro-environment physically moves as the customer moves about the store. The micro-environment is dynamic in that it is engaged in a continual response loop based on the response trigger events of the customer throughout this interactive cycle with the micro-environment.

Described herein are environmentally isolated tissue culture devices that may be used for cell culture, as well as systems including these devices and methods for using them. These devices may include control features for regulating the micro-environment within a well or wells of the device. For example, on-board features may regulate the temperature, humidity, pH, media level, media composition, CO2 / O2 / N2 levels, drug concentration, cell density, byproduct (or product) production, and mixing of materials within the chamber. Material may be added to or withdrawn from the wells of the device without opening the device. Also described herein are controllers for analyzing and controlling the micro- environment within the well. Thus, the plates described herein may be used without requiring a separate incubator, allowing cells to be analyzed (e.g., imaged) continuously, allowing real-time reactions while monitoring under a microscope for hours, days or even weeks.

The presently claimed and disclosed invention relates, in general, to three dimensional micro-environments and, in particular, to three dimensional (“3D”) micro-environments found in inverted-opal scaffolds made from hydrogel therein for controlled release of nutrients. Specifically, the scaffolds have exceptionally ordered, three-dimensional organization that provides excellent porosity, permeability, and transportation properties can that are especially well suited for use as a nutrient carrier in the emerging technologies of drug delivery and cell culture. Methods for incorporation of or to control the release of nutrients and other substances from such scaffold materials are also herein disclosed and claimed.

An apparatus and method for modifying the temperature of a bed environment. In preferred embodiments, the invention is a self-contained, forced air bed warmer which pre-heats the interior sheets and covers of a bed to provide a controlled micro-environment that facilitates relaxation into restful sleep on cold nights. Preferred embodiments include an air conditioning section comprising a body portion and a handle portion, said air conditioning section having an exterior surface that is adapted to receive an edge of a bed cover between said body portion and said handle portion; a fan; a heat transfer element; a temperature sensor; a control circuit connected to said temperature sensor; a timer mounted within said air conditioning section; and an elongated air delivery section having two ends with an air entrance at one end and a primary air exit at the other end.

The invention provides a multi-functional-region cell three-dimensional co-culture method based on a micro-fluidic chip. The chip is composed of a central main channel which is relatively low and side channels which are relatively high and are arranged on two sides, wherein the main channel and the side channels are connected by virtue of trumpet-shaped grid structures. Specifically, the method comprises the following steps: (1) adding collagen solutions different in composition to the sample inlet of the main channel of the chip and applying negative pressure to the outlet of the main channel, wherein the three collagen solutions flow into the main channel and functional regions, which keep distinct boundaries, are formed on the basis of a lamina flow principle; and (2) sterilizing the chip for a whole night through ultraviolet radiation, and directly blending cells to the collagen solutions which are injected into the main channel, so that cell inoculation can be achieved. By virtue of the micro-fluidic chip designed by the invention, a cell three-dimensional culture system, which has a plurality of independent functional regions, can be constructed in one step; and the method has an important application potential in the construction of in vitro complex cell micro-environments.

The invention discloses a nutrient solution cultivation method of Chinese yews and belongs to the method of plant nutrient solution cultivation. The method includes the steps: A, plant treatment: cutting off fibril and reserving main roots to be soaked in carbendazim and naphthylacetic acid; B, planting: planting the Chinese yews inside a planting basket with ceramicite; C, root speeding: placing the Chinese yews inside perlite matrix and enabling intelligentized laminas to be buried inside the perlite matrix, and controlling micro-environment factors to regulate and control a system through a plant non-test-tube rapid propagation expert system; D, root promoting: when matrix roots penetrate out the planting basket, enabling the Chinese yews to be soaked into a nutrient solution water tank and arranging the intelligentized laminas, and controlling the micro-environment factors to regulate and control the system through the plant non-test-tube rapid propagation expert system; E, cultivating to be strong, arranging the intelligentized laminas in the positions of hydrophilous root systems and plant laminas, and controlling the micro-environment factors through the plant non-test-tube rapid propagation expert system; F, modeling: trimming and modeling the Chinese yews into commodity bonsai. By the adoption of the method, breeding time is reduced by 60-80%, the new manual cultivation method of the Chinese yews is initiated, and the new way of utilizing the Chinese yews is expanded.

The nutritious powder with low blood sugar creating index is prepared with fresh milk, no-sugar whole fat soybean powder, concentrated soybean protein, puffed lotus seed powder, isomaltose, fructose, selenium-rich yeast, resistant starch and soluble diet fiber, and through preparing materials, adding lactase to hydrolyze lactose, mixing materials, sterilizing, concentrating, spray drying, cooling and sieving. The nutritious powder has rich nutrients and low blood sugar creating index, contains diet fiber and organic selenium, and may be utilized easily by probiotics in human body to improve intestinal tract micro environment.

The invention discloses a sucking feed for leeches, which relates to the technical field of feedstuff. The sucking feed is prepared from the following components in percentage by weight: 55-80% of fishmeal, 5-15% of conch meal, 5-10% of soymeal, 1-5% of germ meal, 3-5% of blood meal, 1-5% of yeast and 1-2% of chitosan and colloid protein. The preparation method comprises the following steps: preparing raw materials, tedding, preliminary cleaning, grinding and mixing. The sucking feed provided by the invention significantly improves the feeding strength of leeches, promotes the growth of leeches, improves the yield of leeches and the survival rate of young leeches, improves the utilization rate of the feed, improves intestinal micro environment of the leeches, stimulates the leech bodies to emerge strong immune and stress response and improves the immunity and quality of the leeches.

The invention discloses a denitrification dephosphorization device. The device comprises a tower body, wherein a lower cavity chamber, a bearing layer, a stuffing layer and an upper cavity chamber are sequentially arranged inside the tower body from bottom to top; the stuffing layer consists of sulfur and iron; the side wall of the lower cavity chamber is provided with a water inlet, and the side wall of the upper cavity chamber is provided with a water outlet; the iron is iron scraps, cast-iron scraps or sponge iron; and the sulfur is sulfur granules. The denitrification dephosphorization device has following beneficial effects that: a product hydrogen ion (H+) of the autotrophic denitrification reaction is released, so that the reaction activity of the iron scraps in a micro-environment is enhanced, and the dephosphorization effect is obvious; and meanwhile, the existence of the iron has a certain effect on removing the oxygen, promotes an anaerobic environment of a reactor, favors the singleness of the denitrification microorganism in the reactor and enhances the autotrophic denitration reaction. The device has low cost, stable denitrification dephosphorization effect and high removal rate, and is simple in structure and easy to operate, produce and use.

An apparatus and method for modifying the temperature and aromatically conditioning the air and surfaces within a bed environment. In preferred embodiments, the invention is a self-contained, forced air bed warmer or bed warmer / cooler and aromatic infuser which pre-heats, pre-cools and infuses aromatic influences into the interior sheets and covers of a bed to provide a controlled micro-environment that facilitates relaxation into restful sleep on cold or hot nights. Preferred embodiments include an air conditioning section comprising a body portion and a handle portion, said air conditioning section having an exterior surface that is adapted to receive the edge of a bed cover between said body portion and said handle portion; a fan; a heat transfer element; a temperature sensor; a control circuit connected to said temperature sensor; a timer mounted within said air conditioning section; an elongated air delivery section having two ends with an air entrance at one end and a primary air exit at the other end and a means for introducing aromatic influences into the air moving through it.

The invention discloses an ultrasonic assistant hydro-thermal synthesis process for magnetic Fe3O4 nanometer super fine grain. The invention solves the problems of impure products and large grain diameter. The invention has the technical proposal that the form of Fe3O4 crystal nucleus is promoted in the cavitation effect of ultrasonic; cavitation gas bubble is produced in mediums; the pH value of strong ammonia is adjusted to 11 to 13; and the nanometer grain diameter size and the magnetic characteristics are controlled by controlling the hydro-thermal synthesis temperature within range from 140 DEG C to 160 DEG C and within time of 3 to 5 hours, and by changing the micro environment of the air bubble chamber, so as to obtain the dry product which is black magnetic Fe3O4 nanometer powder after being milled. The invention comprises no organic solvent, belonging to full green environmental protection which is a break in the field, and the invention is also the first to use the ultrasonic technology for assistant hydro-thermal synthesis. The invention has the advantages of simple technology, low cost, small powder granularity and even grain diameter. The powder not only can be used as duplicate ink powder, but also can be board used in aspects such as medical, biological technology, magnetic immunocyte separation, DNA separation, nucleic acid hybridization, and preparation for magnetic butt directional medicine carrying micron ball.

The invention discloses a comprehensive improvement method suitable for inland extreme arid area saline-alkali soil. The method is formed by integrating multiple technological innovations of levellingsoil and eliminating salt accumulation in surface soil, returning straw to field and improving a soil body structure so as to block a salinity ascending channel, additionally applying an organic fertilizer and optimizing fertilized soil to improve a crop saline-alkaline tolerance capacity, deep-plowing soil and adjusting grain compositions so as to retard salinity ascending, additionally applyingan improver and creating a low-salt rhizosphere micro-environment, covering by straw and preventing soil salt return, rationally irrigating for salt-leaching and desalting and the like. The technology can be applied for performing straw simplification on preceding crops and rapidly and directly returning to the field, relieving labor intensity of a farmer, adequately using straw nutrient resources for usage by crops in the next season, reducing an applying quantity of a chemical fertilizer, and reducing agricultural production cost. An isolating layer is formed in a soil body, so the ascending of underground water and salinity in the lower soil body is retarded, and the salt accumulation in the surface soil and the salt return are reduced. The method has multiple functions of improving the saline-alkali soil, improving production capacity of cultivated land, increasing production, saving cost and increasing income and the like, and is remarkable in economic, social and ecological environment benefits.

The invention discloses a city navigation system construction method based on positioning two-dimensional codes. The method comprises steps that: (a), multiple positioning two-dimensional codes are arranged in a city, and the positioning two-dimensional codes are numbered; (b), space plotting for each positioning two-dimensional code is carried out to acquire accurate space coordinate information and geography environment information, and the space coordinate information relates to longitude and latitude coordinates; (c), the space coordinate information and the geography environment information are inputted to a database, and integration of the information is carried out to form an application program; and (d), a mobile terminal is utilized by a user to scan the positioning two-dimensional codes to acquired the space coordinate information and the geography environment information of corresponding positions. The invention further provides a city navigation system based on the positioning two-dimensional codes, and the city navigation system corresponds to the method. According the method and the system, accurate self-positioning of the user is carried out through a two-dimensional code scanning mode, detailed space data around the present position of the user is acquired simultaneously through the mobile Internet, and accurate navigation of a microscopic environment is carried out according to an object inputted by the user.

A portable or wearable device and related methods of use that provide an altered microenvironment surrounding the respiratory path, specifically a person's mouth or nose, wherein the air in the microenvironment is either filtered to remove pollutants or pathogens, or wherein the air is altered by therapeutic or pharmaceutical or other agents, which disinfect the air or otherwise provide a desirable characteristic. In an alternative embodiment, a therapeutic or pharmaceutical agent is delivered to the air path to the individual wearing the device of the present invention.

A substrate thermal processing system. The system has at least one substrate holding module having a housing configured for holding an isolated environment therein. A substrate heater is located in the housing and has a substrate heating surface. A substrate cooler is located in the housing and having a substrate cooling surface. A gas feed opening into the housing and feeding inert or reducing gas into the housing when the substrate is heated by the heating surface. A gas restrictor is within the housing restricting the fed gas between the substrate heating surface and a surrounding atmospheric region substantially surrounding the substrate heating surface in the housing and forming an aperture through which the fed gas communicates with the atmospheric region.

The invention relates to a core-shell structure catalyst. Nanometer particles of a metal active component and nanometer particles of an assistant are used as a core, and a carrier and the assistant are used as a shell. The core-shell structure catalyst disclosed by the invention is wrapped by the shell layer, a micro-environment is formed in the closed interior of the shell layer, and in a catalytic reaction process, local high concentration is formed in an inner cavity usually by accumulation of reactants, so that the reaction is promoted to be relatively efficiently performed, and the integral activity of the catalyst is improved. In addition, in multiple liquid phase reactions, the shell layer can prevent active species in the micro-environment inside from outwards losing, and thus the service life of the catalyst is prolonged. In addition, for certain organic matter catalytic reactions, the shell layer can prevent carbon deposit in a reaction process, and the carbon deposit-resisting property of the catalyst is improved; meanwhile, after one layer of stable matter coats the surface of certain nanometer particles which are likely to agglomerate and inactivate to form the core-shell structure, the agglomeration trend of the nanometer particles is greatly weakened, and the stability of the catalyst is improved.

The present invention relates to analytical testing devices comprising a single channel with micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, to performing coagulation assays using a single channel with micro-environment sensors in a point of care test cartridge. For example, the present invention may be directed to a sample analysis cartridge including an inlet chamber configured to receive a biological sample and a conduit fluidically connected to the inlet chamber. The conduit includes a sensor chip including a first micro-environment sensor and a second microenvironment sensor, and a fluid lock valve. The sample analysis cartridge further includes a pump configured to push the biological sample over the first micro-environment sensor and the second microenvironment sensor to the fluidic lock valve such that the biological sample is positioned over the first micro-environment sensor and the second micro-environment sensor.

The method provides a micro-fluidic chip capable of producing stable concentration gradient and a cell co-culture method. The micro-fluidic chip is composed of a perfusion channel, an inlet pool, a culture chamber, a waste liquid pool and a micro channel. Direct coculture and mixed coculture of cells can be carried out on a chip with an area of few square centimeters, and at the same time, the stable concentration gradient of cell chemotactic factor can be maintained, so that a micro environment of tumor cells is constructed, and mutual effects between biological cells and cytokines, between cells and matrixes, between cells can be simulated effectively. The micro-fluidic chip has the advantages of simple operation, simple manufacture, small sample usage and the like, and has significant biomedical research values and economic values.

The invention relates to the treatment of industrial wastewater and domestic sewage containing nitrogen, in particular a membrane bioreactor (MBR) which can realize the function of synchronous nitrogen removal of nitrification and denitrification. The reactor comprises a reactor cylinder, a membrane component, spherical elastic filler, dissolved oxygen (DO) electrode, a pH electrode, a thermometer and other on-line monitoring and controlling components. A water production end on an internal membrane component of the MBR is connected with a water production pressure gauge and a vacuum pump. Except the membrane component, the inside of the MBR is also evenly provided with the spherical elastic filler which forms an integer by connecting in series from top to bottom and is fixed on the top and bottom of the reactor. The bottom of the MBR has a micropore aerator connected with an air pump for the aeration utilization of the MBR. The membrane bioreactor introduces the porous spherical elastic filler into the MBR and regulates the micro-environment inside the MBR, so as to realize the function of synchronous nitrogen removal of nitrification and denitrification. The membrane bioreactor has small land occupancy and simple operation, saves energy consumption, can remove a plurality of pollutants of organic matters, ammonia nitrogen, etc., and is applicable to the treatment of industrial organic wastewater, domestic sewage, etc.

The invention discloses a three-dimensional silk fibroin scaffold insoluble in water, and preparation and application of the three-dimensional silk fibroin scaffold. A preparation method includes the steps of injecting silk fibroin solution with the mass concentration of 0.3-30% into a mold, and obtaining a three-dimensional silk fibroin scaffold after freeze-drying; performing humid and heat crosslinking for the mold under the condition that the temperature ranges from 50 DEG C to 100 DEG C and the relative humidity ranges from 70% to 100%; and drying, removing the mold and obtaining the three-dimensional silk fibroin scaffold insoluble in water. Silk fibroin is used as a raw material, and biocompatibility is good; a preparation process is non-toxic and environment-friendly, and shape, aperture and porosity parameters of the scaffold are easy to control; the pore wall of the scaffold is nano-scale, the aperture of the scaffold is micron-scale, an extracellular matrix micro-environment is simulated, and the three-dimensional silk fibroin scaffold is used as a three-dimensional cell culture vector or a three-dimensional plasmid transfection vector when used externally; and the three-dimensional silk fibroin scaffold is used in the aspects of cartilage scaffolds, fat scaffolds, bone scaffolds, muscle scaffolds and the like when used in the internal tissue engineering field.

A sterilizable bio-reactor comprising a three-dimensional reactor culture assembly substantially equivalent to a bone marrow micro environment, an inert bio-compatible scaffolding material located on a base of the reactor culture assembly to provide a micro environment identical to the micro environment in human bone marrow, for cultivating stem cells in the scaffolding, forming part of a sterilizable bio-reactor device, and a process for the expansion of haemopoietic stem cells derived from Human Umbilical Cord Blood for therapeutic use, comprising growing haemopoietic stem cells in the bio-degradable non-toxic bio-compatible scaffold while providing necessary nutrition and gasses cultivating the stem cells in the scaffolding material to provide for the cell growth in the bio reactor, and supplying mobilizing oxygen and carbon dioxide to maintain gas tension for optimal expansion of the stem cells, and circulating media containing micro and macro nutrients and growth factors to establish gradients within the enclosure.

The invention relates to a novel measurement method and the device thereof, which combines the time-resolved self-fluorescence lifetime imaging technology and a laser scanning confocal ophthalmoscopeand realizes the early diagnosis of the ocular fundus diseases by obtaining and analyzing the self-fluorescence intensity and the service life information of the ocular fundus. The light which is emitted by a pulse laser is sent to the scanning head of the laser scanning confocal ophthalmoscope to excite the ocular fundus inner-source flgorgen, and the fluorescence which is emitted from the ocularfundus is collected by a time-correlated single photon counter or a high-repetition-rate synchronous scanning camera, so as to realize the service life measurement and the imaging of the self-fluorescence. As the service life of the self-fluorescence of the ocular fundus is very sensitive to the micro-environment and the cell metabolism state of flgorgen molecule and is not affected by the difference of the intensity of the flgorgen of the ocular fundus, the measurement of the fluorescence service life provides a brand new route for the detection of ocular fundus diseases and the obtainment of the function information of ocular fundus. The invention can become the solution and the basis of the early diagnosis of various ocular fundus diseases, which plays an important role in pathogeny research, clinical diagnosis, staging and typing, prognosis judgement, real-time observation and the analysis of the development of ocular fundus diseases, therefore the invention can be widely appliedin the field of medical research and clinical medical diagnosis.

The invention belongs to the field of treatment and regeneration of urban sewage, and provides a quick starting method for a technology for simultaneous denitrification and COD removal under the condition of normal-temperature and low-C / N sewage. The method comprises the steps as follows: firstly inoculating some mature CANON sludge, and enabling the CANON sludge to perform biofilm culturing on volcanic rock filtering material, and quickly constructing an aerobiotic AOB and anammox oriented microbial system; then reducing the inflowing water substrate concentration and adjusting the aeration and hydraulic retention time, so as to improve the nitrogen removal load, and realize the high-load stable operation of the CANON technology under the condition of a medium ammonia nitrogen substrate; finally adding an organic carbon source into the inflowing water, performing heterotrophy for the growth of denitrifying bacteria, and controlling the temperature, free ammonia, aeration and other conditions, so as to optimize the aerobiotic AOB, anammox and denitrifying bacteria coexisted micro-environment, and successfully start an SNAD technology. According to the invention, the difficult problems that a large amount of organic carbon sources are required to be added for biological denitrification in the long term and the cost is prodigious are solved, and a method is provided for starting of the SNAD technology under the condition of normal-temperature and low-C / N simulated wastewater.

Methods of enabling or improving the ability of a hydrogel to swell in the stomach of an animal and / or increasing the amount of time said hydrogel remains swollen in the stomach are described herein. In one embodiment, a polymer is administered in combination with one or more pH modifying agents which raise and maintain the pH of the micro environment of the polymer and / or the stomach in order inducing swelling in the polymer. The polymer can be a homopolymer, a copolymer, or a polymer blend or composite. In one embodiment, the polymer is a superabsorbent polymer (“SAP”). The polymers can also be administered with one or more active agents, such as appetite suppressants. The pH modifying agent and / or the active agent can be administered simultaneously with the polymer in the same dosage form, simultaneously with the polymer in separate dosage forms, or sequentially. The compositions are formulated for oral administration. The formulation can include drugs for delivery to the stomach, such as antibiotics, or the hydrogel can be used as a filler, for example, for obesity control. The formulation an also be used to enhance gastric retention, for example, for controlled drug delivery. Methods of delivering a drug are also described herein, along with medicaments for carrying out the methods of the present invention.

The invention relates to a dual sensitive amphiphilic triblock copolymer containing disulfide bond and acylhydrazone bond and a preparation method and an application of the dual sensitive amphiphilic triblock copolymer. A BAB type amphiphilic triblock copolymer consists of a hydrophobic polyester block A and a hydrophilia polyethylene glycol block B, wherein the block A is polyether containing active terminal amino group and disulfide bond; the block B is benzaldehyde ester of an ethylene glycol monomethyl ether or single terminated polyoxyethylene polypropylene oxide copolymer; the block A and the block B are connected through acid sensitive acylhydrazone bond generated from reaction of active terminal amino group and aldehyde group. The dual sensitive amphiphilic triblock copolymer is good in biocompatibility and biodegradability, can be formed into nanoparticles with oxidation reduction sensitivity and acid sensitivity in a water medium in a self-assembling manner, can wrap hydrophobic medicines to form nano medicine preparations, and can promote rapid release of medicines in tumor cells due to fracture of disulfide bond and acylhydrazone bond which are sensitive to oxidation reduction in a high concentration glutathione and acid micro environment in the tumor cells.

The invention relates to a multifunctional modularized floating island for in-situ restoration of polluted rivers and lakes. The floating island consists of five functional modules including a waterscape floating island module, a flexible filler floating island module, an aeration floating island module, a power supply floating island module and a functional floating island module. Each functional module is formed by floating beds in the same shape and size; different functional components are matched on the floating beds respectively so as to form the above functional modules. 2-5 different functional modules are selected in proportions according to the water quality difference and area load of the polluted river, and are optimally combined, thus various micro-environments are formed along the water flow direction, the self-cleaning ability of rivers and lakes are prompted, and the COD (chemical oxygen demand) and ammonia and nitrogen of the polluted water can all reach the V-type standard of surface water. With the adoption of the technology, the problems of single function, poor applicability and low water quality improving efficiency of the plant floating island structure in the prior art are solved, and the in-situ high-efficiency water quality improvement of water in polluted rivers and lakes is achieved.