2 results about "Esomeprazole Sodium" patented technology

This invention discloses an esomeprazole sodium and its purification method, relating to the field of drug synthesis technology. The purification method includes the following steps: S1, mechanically grinding crude esomeprazole sodium with a composite solid purification additive to obtain an activated mixture; the composite solid purification additive is a composition of diisopropyl tartrate and hydroxypropyl-β-cyclodextrin, and the mass ratio of diisopropyl tartrate to hydroxypropyl-β-cyclodextrin is (1~5):(2~4); S2, adding a washing solvent to the activated mixture and stirring and washing, then performing solid-liquid separation to obtain a solid wet product; the washing solvent includes ethyl acetate, methyl tert-butyl ether, or isopropyl ether; S3, drying the solid wet product to obtain purified esomeprazole sodium. This purification method is not only simple in process and has a high product yield, but also does not introduce new impurities, and the product has high optical and chemical purity.

The utility model discloses an esomeprazole sodium preparation mixing device which comprises a tank body, the tank body is of a structure with an opening in the bottom, a supporting assembly is arranged on the outer side of the tank body, a cover plate is fixedly connected to the top in the tank body, two material ports are formed in the top of the cover plate, and the two material ports are arranged in the tank body. The top of the cover plate is fixedly connected with two feeding bins communicated with the material ports, a material mixing assembly for stirring and mixing materials is arranged in the tank body, a conical leakage disc is fixedly connected to the position, close to the bottom, in the tank body, and the inner walls of the two sides of the tank body are each fixedly connected with two telescopic rods. According to the material mixing device, the discharging speed can be adjusted and controlled by changing the distance between the two material blocking plates, the using effect of the material mixing device is improved, materials can be better mixed, the stirring and mixing effect of the material mixing device on the materials is improved, and the material mixing effect is improved. And a worker can conveniently collect the mixed materials, so that the use convenience of the material mixing device is improved.