4 results about "Esomeprazole Sodium" patented technology

The invention discloses a method for determining potential genotoxic impurities in esomeprazole sodium by HPLC (High Performance Liquid Chromatography), which comprises the following steps: preparing a test solution: taking 20-100mg of esomeprazole sodium, precisely weighing, putting into a 10mL measuring flask, adding methanol, carrying out ultrasonic treatment to dissolve a sample, diluting to a scale by using methanol, and shaking uniformly; a proper amount of 4-methoxy-3, 5-dimethyl pyridine nitrogen oxide is taken, precisely weighed and quantified with methyl alcohol, and the reference substance solution containing 73-360 ng of 4-methoxy-3, 5-dimethyl pyridine nitrogen oxide in 1 mL of the solution is prepared; respectively carrying out HPLC (High Performance Liquid Chromatography) detection on the reference substance solution and the test solution, and determining the content of the impurity 4-methoxy-3, 5-dimethyl pyridine nitrogen oxide in the esomeprazole sodium by adopting an external standard method. The method has the advantages of high separation efficiency, high analysis speed, high detection sensitivity and low detection cost, and can effectively control the quality of esomeprazole sodium.

This invention discloses an esomeprazole sodium and its purification method, relating to the field of drug synthesis technology. The purification method includes the following steps: S1, mechanically grinding crude esomeprazole sodium with a composite solid purification additive to obtain an activated mixture; the composite solid purification additive is a composition of diisopropyl tartrate and hydroxypropyl-β-cyclodextrin, and the mass ratio of diisopropyl tartrate to hydroxypropyl-β-cyclodextrin is (1~5):(2~4); S2, adding a washing solvent to the activated mixture and stirring and washing, then performing solid-liquid separation to obtain a solid wet product; the washing solvent includes ethyl acetate, methyl tert-butyl ether, or isopropyl ether; S3, drying the solid wet product to obtain purified esomeprazole sodium. This purification method is not only simple in process and has a high product yield, but also does not introduce new impurities, and the product has high optical and chemical purity.

The application belongs to the technical field of medicine and chemical industry, and particularly relates to a method for preparing esilprazole sodium by a continuous flow method. The preparation method comprises the following steps: (1) adding esilprazole sulfide, a sodium hydroxide solution and an iron catalyst into acetone to obtain an esilprazole sulfide alkali liquor; (2) respectively feeding the esilprazole sulfide alkali liquor and oxygen through flowmeters into a tubular reactor to perform a reaction; and (3) adding ethyl acetate into the organic phase obtained in the step (2) after being evaporated to dryness, and then performing beating, filtering and drying to obtain esilprazole sodium solid. The continuous flow reaction process is used to replace the traditional kettle process, and oxygen is used as an oxidizing agent to perform an oxidation reaction, so that the conditions are mild, the process parameters are easy to control and adjust, the safety is improved, the reaction time is greatly shortened, the reaction heat transfer effect is good, the whole experimental operation is more simple, and the method is suitable for industrial continuous production.

The utility model discloses an esomeprazole sodium preparation mixing device which comprises a tank body, the tank body is of a structure with an opening in the bottom, a supporting assembly is arranged on the outer side of the tank body, a cover plate is fixedly connected to the top in the tank body, two material ports are formed in the top of the cover plate, and the two material ports are arranged in the tank body. The top of the cover plate is fixedly connected with two feeding bins communicated with the material ports, a material mixing assembly for stirring and mixing materials is arranged in the tank body, a conical leakage disc is fixedly connected to the position, close to the bottom, in the tank body, and the inner walls of the two sides of the tank body are each fixedly connected with two telescopic rods. According to the material mixing device, the discharging speed can be adjusted and controlled by changing the distance between the two material blocking plates, the using effect of the material mixing device is improved, materials can be better mixed, the stirring and mixing effect of the material mixing device on the materials is improved, and the material mixing effect is improved. And a worker can conveniently collect the mixed materials, so that the use convenience of the material mixing device is improved.