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315results about How to "Improve compliance" patented technology

Ciliary muscle adjustment training system and method based on eye movement tracking

The invention relates to the technical field of visual health management, in particular to a ciliary muscle adjustment training system and method based on eye movement tracking, and the method comprises the steps: collecting eye movement data of a fixation point track, an adjustment amplitude change rate and pupil response time in real time, and combining personalized parameters such as the age of a user, diopter and a training target; inputting a ciliary muscle training dynamic planning algorithm module, dynamically generating a stage scheme containing a training action type, a single-group duration, a stimulation interval and a focal length adjustment strategy, and adaptively adjusting the strategy according to real-time adjustment stability and a historical ability curve; through multi-dimensional matching analysis of a pre-stored standard eye movement template, a training specification score is calculated from the track goodness of fit, speed uniformity, amplitude standard-reaching rate and binocular coordination, visual fatigue parameters are obtained based on continuous training duration, pupil fluctuation and retina reflex change, a scoring result is dynamically corrected, and a visual fatigue evaluation result is obtained. Personalized, self-adaptive and quantitative safety control of the training process is realized.
Owner:QINGTIAN HEMU INFORMATION TECHNOLOGY CO LTD

Soluble skin-adhering microneedle for delivering enterovirus inactivated vaccine as well as preparation method and application of soluble skin-adhering microneedle

The invention relates to the technical field of biological medicines, in particular to a soluble skin-adhering microneedle for delivering an inactivated enterovirus vaccine as well as a preparation method and application of the soluble skin-adhering microneedle. Sodium hyaluronate is adopted as a film forming material to wrap an enterovirus 71 type (EV71)-coxsackie virus A16 (CA16) type bivalent inactivated vaccine antigen, and a needle body layer of the soluble microneedle is formed; the substrate layer is prepared from a pullulan material, so that the microneedle patch with a stable overall structure is formed. The technology provided by the invention is completed in a clean environment, and the vaccine patch which is qualified through sterility detection is obtained. The soluble microneedle disclosed by the invention has good antigen stability under the condition of 2-8 DEG C. In animal experiments, the microneedle is attached to the skin surface of a mouse for skin-adhering immunization, a strong immune response reaction can be induced, good immunogenicity is shown, and a novel, safe and effective vaccine delivery way is provided for prevention and control of the infantile hand-foot-and-mouth disease.
Owner:INST OF MEDICAL BIOLOGY CHINESE ACAD OF MEDICAL SCI

Standardized work management system of standard system revision project

The invention discloses a standardized work management system for a standard system revision project, and the system comprises a heterogeneous data fusion module which captures the multi-modal process data of each stage in real time, and converts the multi-modal process data into a process state vector sequence; a time sequence constraint graph rule base is built in the compliance graph calculation module, a process state graph with time sequence attributes is constructed, and the multi-dimensional compliance deviation degree is calculated through graph mode matching; the strategy generation and conflict resolution module is used for generating a candidate set with a weight adjustment instruction through a learnable strategy priority ranking model based on the deviation degree and resolving logic conflicts; and the trusted execution and feedback closed loop module atomizes an execution instruction and carries out uplink evidence storage, and collects project response data to update rule base parameters and model weights online. According to the method, automatic and accurate compliance evaluation is realized through graph calculation, self-evolution of the system is realized through intelligent strategy generation and credible execution feedback, and the management efficiency, compliance and intelligent level are comprehensively improved.
Owner:SOUTHWEST TECHNICAL ENGINEERING RESEARCH INSTITUTE OF CHINA SOUTH IND GROUP

Composition for treating nerve headache and preparation method thereof

The invention provides a composition for treating nerve headache and a preparation method thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: carrying out steam explosion treatment on traditional Chinese medicine powder, adding the traditional Chinese medicine powder into saline water, decocting, filtering, standing filtrate to separate out a hydrochloric acid extract, adding filter residues into ethanol, adsorbing by a magnetic adsorbent, separating by a magnet, eluting, desorbing, recovering an eluent to obtain an alcohol extract, mixing and grinding the alcohol extract, the hydrochloric acid extract and flunarizine hydrochloride / nimodipine eutectic, and filling capsules with the alcohol extract and the flunarizine hydrochloride / nimodipine eutectic. The composition for treating the nerve headache is prepared. The traditional Chinese medicine composition treats neuropathic migraine through a method of combining traditional Chinese medicine and western medicine, treats both symptoms and root causes, and is good in effect and quick and lasting in effect.
Owner:YANG SERIES (SHANDONG) BIOTECHNOLOGY CO LTD

Compositions and their use in the manufacture of products for the prevention of ocular disease, slowing of visual acuity decline

The present application relates to the field of medicine, in particular to a composition and its use in the preparation of a product for preventing eye diseases and slowing down visual acuity decline. The present application provides a composition comprising, in parts by weight, any two or more of a carotenoid complex 2-10 parts, a vitamin complex 0.1-1 part, a mineral complex 0.01-0.5 part, and a plant active complex 5-15 parts. The present application provides a composition and its use in the preparation of a product for preventing eye diseases and slowing down visual acuity decline.
Owner:ZHENGZHOU ANZHENG KANGDE BIOPHARMACEUTICAL CO LTD

A control management system for a modular remote-linked gas meter

PendingCN122591006AReduce maintenance costsRealize remote valve control
The application discloses a control management system of a modular remote linkage gas meter, relates to the technical field of gas meter control, and comprises a gas meter measurement base table, which only comprises a flow measurement unit, an electric control valve and a Bluetooth beacon module. The Bluetooth beacon module is used for broadcasting a base table equipment ID, a real-time flow cumulative value and a valve state. The control management system of the modular remote linkage gas meter is characterized in that the gas meter measurement base table and the intelligent control panel are physically independently arranged, communication, interaction and safety control functions are completely decoupled from the measurement body, a double-mode communication cooperation unit is arranged in the control panel, and a Bluetooth link and a wireless network link are simultaneously managed, so that the basic functions of gas safety control can continuously operate under any network condition, and a remote monitoring blind area caused by a single communication link fault is avoided.
Owner:FATO GAS EQUIP (HEBEI) LTD

An optimization method for integrated circuit design data

This invention belongs to the field of integrated circuit design technology, specifically relating to a method for optimizing integrated circuit design data. This method first constructs a "tool-layer-semantic" data acquisition architecture, integrating multi-channel parallel acquisition units to collect heterogeneous data from multiple sources. Compliance pre-verification is performed through hardware logic circuits and a verification rule base, extracting key data identifiers. A three-level incremental compression strategy based on key data priority, combined with an intelligent index integrating multi-dimensional indexes, is used for compression and storage. The stored data undergoes multi-dimensional optimization, including semantic deduplication, priority optimization, format conversion, and source quality backtracking, forming a unified format optimized semantic. Through an interactive interface, it is adapted and interacted with electronic design automation tools. After consistency verification and performance testing feedback loops, the final design data and full-process traceability information are obtained and stored. This invention achieves unified management, efficient compression, intelligent optimization, and full-process traceability of design data.
Owner:CHONGQING QIANFU TECHNOLOGY CO LTD

Unmanned express delivery vehicle control system and method based on operation state perception

The invention discloses an unmanned express delivery vehicle control system and method based on operation state perception, and relates to the field of unmanned express delivery vehicle control systems. The method comprises the following steps: acquiring vehicle-mounted data in a driving period through a vehicle-mounted sensor array, performing time alignment and validity marking on the vehicle-mounted data to obtain a data quality label, constructing an evidence item set based on the data quality label, generating a sub-portrait label set according to the evidence item set, and displaying the sub-portrait label set in the driving period. And generating a portrait parameter set based on the sub-portrait label set through a preset priority rule and a persistence judgment strategy. Although the scheme has excellent performance in the aspects of improving system adaptability, safety, dynamic decision-making capability, reviewable performance and resource utilization efficiency, the problems of sensor faults, data loss, real-time data processing bottleneck, label interpretation errors and the like may influence the real-time response and decision-making precision of the system in a complex or extreme environment. Therefore, the overall performance and stability are reduced, especially under the condition of high load or low signal.
Owner:LI KECHONG (SHANDONG) INTELLIGENT TECHNOLOGY CO LTD

Application of plasma specific piRNA marker in preparation of reagent for detecting gastric cancer

The invention discloses application of a plasma specific piRNA marker in preparation of a reagent for detecting gastric cancer. The piRNA marker is composed of the following plasma piRNAs: hsa-piR-21921, hsa-piR-9725, hsa-piR-19960, and hsa-piR-23621, and the piRNA marker is composed of the following plasma piRNAs: hsa-piR-21921, hsa-piR-9725, hsa-piR-19960, and hsa-piR-23621. The invention provides the piRNA marker for gastric cancer detection, and the piRNA marker can be used for preparing a reagent for gastric cancer detection and has the advantages of high accuracy, high sensitivity and high specificity.
Owner:THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV

Genetic center molecule genetic laboratory management system

PendingCN122243381APromote continuous improvementPromote innovation and developmentNatural language data processingOffice automation
This invention discloses a molecular genetics laboratory management system for a genetics center, belonging to the field of laboratory information management technology. It provides real-time monitoring of sample status, dynamic scheduling of subsequent tasks, and early warnings for near-expiration and overdue samples. Experimental data is collected through structured electronic task sheets, and the analyzed genetic variation information is dynamically updated to a mutation database. Historical variation data is intelligently recommended for report generation. Report content is automatically populated based on variation data and adapted to project templates. It supports configurable multi-level review processes, enabling online collaboration and operation tracking. Based on review results, first-use acceptance and automatic deduction of inventory for reagents and consumables are performed. Based on resource linkage and traceability, gene disease databases and mutation databases are collaboratively constructed. This system achieves fully automated management from intelligent sample monitoring and scheduling to automatic report generation and review, significantly improving the operational efficiency, data accuracy, and resource utilization of the genetics laboratory.
Owner:REPRODUCTIVE & GENETIC HOSPITAL OF CITIC XIANGYA CO LTD

Data encryption method and device, equipment and storage medium

The invention discloses a data encryption method and device, equipment and a storage medium, and relates to the technical field of information security, and the method comprises the steps: receiving a data encryption request which is sent by a business application and carries a tenant identifier, an application identifier and to-be-encrypted data; querying an application key ciphertext corresponding to the application identifier and a tenant key ciphertext corresponding to the tenant identifier from a tenant security layer, and obtaining a platform master key from a platform security layer; decrypting the target tenant key ciphertext by using the platform master key in the tenant security layer to obtain a tenant key plaintext, and decrypting the application key ciphertext by using the tenant key plaintext to obtain an application key plaintext; and sending the application key plaintext and the to-be-encrypted data to a virtual cipher machine allocated to the current tenant in advance, encrypting the to-be-encrypted data based on the application key plaintext to obtain a data ciphertext, and sending the data ciphertext to the service application. According to the invention, the security of the data encryption process can be improved, and data leakage is avoided.
Owner:HANGZHOU FULANKE INFORMATION SECURITY TECH CO LTD

A pharmaceutical composition for preventing and treating influenza virus and use thereof

The present application discloses an anti-influenza virus pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof or a compound of formula (II) or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 are as defined in the specification. The present application also discloses the use of the pharmaceutical composition in the preparation of a medicament for preventing or treating influenza.
Owner:HEFEI COSOURCE PHARMA CO LTD

Intelligent diagnosis and compliance automatic verification system and method for nuclear power plant maintenance procedures

The application belongs to the technical field of digitalization and intelligent application in nuclear power industry, and provides an intelligent diagnosis and compliance automatic checking system and method for maintenance regulations of a nuclear power plant, the system comprising a rule base management module, an intelligent analysis module, a rule engine module and a user interaction module, the method creating and maintaining a machine-readable rule base for checking maintenance regulations of a nuclear power plant, acquiring and analyzing a maintenance regulation file to be checked, generating a structured regulation object model, matching and evaluating the regulation object model with rules in the rule base, generating a diagnosis result set, displaying the diagnosis result set to a user, and providing interactive modification guidance.The application performs automatic and real-time compliance checking and logic diagnosis on maintenance regulations of a nuclear power plant, so as to replace most repetitive and rule-based manual review work with machine automatic checking.
Owner:CHINA NUCLEAR POWER OPERATION TECH CORP

Traditional Chinese medicine tea drink for preventing and treating oral mucosa diseases and preparation method of traditional Chinese medicine tea drink

PendingCN122075630AImprove microcirculationlow recurrence ratePowder deliveryDigestive systemMedicinal herbsDisease
The invention discloses a traditional Chinese medicine tea drink for preventing and treating oral mucosa diseases and a preparation method of the traditional Chinese medicine tea drink. The traditional Chinese medicine tea drink is prepared from 10-15 parts of radix astragali, 8-12 parts of radix codonopsis, 6-10 parts of radix salviae miltiorrhizae, 5-9 parts of radix angelicae sinensis, 3-6 parts of fructus psoraleae, 6-9 parts of rhizoma polygonati, 6-9 parts of radix adenophorae, 6-10 parts of rhizoma atractylodis macrocephalae, 5-9 parts of radix ophiopogonis, 3-5 parts of radix glycyrrhizae, 4-6 parts of pericarpium citri reticulatae and 5-8 parts of herba taraxaci. Aiming at the core pathogenesis of low immunity, long-term deficiency, long-term deficiency and kidney-yang insufficiency of patients suffering from oral mucosa diseases, qi tonifying, blood activating and kidney-qi strengthening are taken as a core treatment method, the formula is scientific and reasonable, all the medicinal materials act synergistically, the overall immune function of the body is adjusted, T lymphocyte subpopulation imbalance and cell factor network disorder are improved, and the curative effect is good. The oral mucosa microcirculation is improved, local inflammation is relieved, the immunity of a patient is improved fundamentally, the recurrence rate of oral mucosa diseases is reduced, and the problems that an existing tea drink is not high in pertinence and limited in curative effect are solved. The tea drink is appropriate in taste, good in compliance, high in safety and suitable for people with various oral mucosa diseases and low immunity.
Owner:WEST CHINA STOMATOLOGICAL HOSPITAL OF SICHUAN UNIV

Special lung atomization therapeutic apparatus for internal medicine of traditional Chinese medicine

PendingCN121971755AAvoid subtle physical and chemical effectssave operating timeMedical atomisersInhalatorsDrugs solutionSurgery
The invention provides a special lung atomization therapeutic apparatus for the internal medicine of traditional Chinese medicine, and relates to the technical field of medical instruments, the special lung atomization therapeutic apparatus comprises an atomizer body, an atomization tank, a mist discharging pipe and a connecting pipe, the connecting pipe is inserted into a connecting plug at the bottom end of the atomization tank, and the other end of the connecting pipe is inserted into the air outlet end of the atomizer body; the double-cavity isolation type atomization tank is adopted, and aiming at the scene that salbutamol sulfate, budesonide and the like are compatible but need to be dosed for several times, through the design of the upper-layer independent medicine storage cavity, the lower-layer independent medicine storage cavity and the isolation gas circuit, the medicine can be dosed for several times, and the medicine can be dosed for several times. After the first liquid medicine is atomized, treatment is not required to be interrupted to replace a container or detach an air pipe, and the second medicine can be quickly switched only by cleaning the mask, so that the problems of tedious operation and treatment interruption of fractional atomization of a single medicine tank are solved, and tiny physical and chemical influence possibly caused by advanced mixing of a large amount of liquid medicine is avoided; and meanwhile, the operation time in the emergency scene is remarkably shortened.
Owner:THE SECOND PEOPLES HOSPITAL OF SHANDONG PROVINCE (SHANDONG PROVINCIAL EAR NOSE & THROAT HOSPITAL SHANDONG PROVINCIAL INST OF EAR NOSE & THROAT)

Hyperspectral Imaging Device and Control Method for the Anterior Segment

ActiveCN120918565BImprove complianceAcquisition speed is fastGonioscopes
This application provides a hyperspectral imaging device for the anterior segment of the anterior segment, comprising: an illumination optical path including a light source; an imaging optical path; a first beam splitter for splitting the light emitted from the imaging optical path into reflected light and transmitted light; an image acquisition optical path for receiving reflected light and converting the reflected light's optical signal into an electrical signal; a hyperspectral data acquisition optical path for receiving transmitted light; a scanning mirror with an adjustable angle; and a controller configured to adjust the deflection angle of the scanning mirror based on the position of the anterior segment region to be detected contained in the image, so that the light reflected from the anterior segment region to be detected can be projected into the hyperspectral data acquisition optical path along its optical axis. The device provided by this application offers doctors more reference information for disease classification and diagnosis, significantly reduces the impact of eye tremors on spectral data, and improves accuracy.
Owner:CHENGDU FENGLI MEDICAL TECHNOLOGY CO LTD

Serum substitute compatible umbilical cord mesenchymal stem cell culture medium additive composition and application thereof

The invention discloses a serum substitute compatible umbilical cord mesenchymal stem cell culture medium additive composition and application thereof. The serum substitute compatible umbilical cord mesenchymal stem cell culture medium additive composition is prepared from the following components in parts by mass: 15 to 25 parts of platelet-derived growth factor-BB; 15 to 25 parts of basic fibroblast growth factors; 8 to 12 parts of transforming growth factor-beta; and 8-12 parts of recombinant human insulin. The serum substitute compatible umbilical cord mesenchymal stem cell culture medium additive composition and the application thereof disclosed by the invention have the following beneficial effects: (1) the proliferation efficiency is remarkably improved; (2) the cell morphology and dryness can be well maintained; and (3) the compliance and the compatibility are good.
Owner:HAINAN QIYAN STEM CELL ANTI AGING HOSPITAL CO LTD

Metal core enhanced double-barrier piezoelectric nanosystem, and preparation method and application thereof

PendingCN122251578AEfficient CatalysisMultiple breakthroughs in security and stabilityEnergy modified materialsPharmaceutical non-active ingredientsBarium titanateBiocompatibility
The application belongs to the field of medical materials, and particularly relates to a metal core enhanced double-barrier piezoelectric nano system and a preparation method and application thereof. The preparation method comprises the following steps: first, a core-shell structure of'metal@mesoporous titanium dioxide@mesoporous barium titanate' is prepared through a step-by-step reaction, and then the target nanoparticles are obtained through lipid wrapping. The system innovatively constructs a double-barrier structure, can self-trigger active oxygen under a physiological pressure of 4 mmHg, realizes endogenous pressure self-driven treatment of malignant ascites, has the advantages of low pressure, high catalytic efficiency, long-term structural stability and good biocompatibility, solves the problems that existing treatment methods are highly invasive and depend on exogenous stimulation, and provides a new safe and efficient technical scheme for the treatment of malignant ascites.
Owner:CHENGDU INTERGENO BIOTECHNOLOGY CO LTD

A retail business based financial document generation system and method

PendingCN122288901AFix mapping fixed issueseasy to handleTransaction dataFinancial transaction
This invention discloses a financial voucher generation system and method based on retail business, belonging to the field of data processing technology. The system includes the following steps: acquiring retail transaction data, which includes transaction amount and at least one transaction attribute information; dynamically matching corresponding accounting rules from a preset accounting rule library based on the transaction attribute information; and defining the amount allocation logic among multiple accounting entities using the accounting rules. This invention solves the problem of rigid accounting rules in existing systems by acquiring retail transaction data containing transaction amount and multi-dimensional transaction attributes, dynamically matching and adapting accounting rules from a preset accounting rule library based on the transaction attributes, and then dynamically determining the account mapping relationship from an accounting account mapping library by combining the accounting rules and transaction attributes, thus solving the problem of fixed account mapping. Finally, it automatically decomposes the transaction amount to generate multi-accounting entity accounting entries based on the accounting rules and account mapping relationship.
Owner:CHENGDU UNIVERSITY OF TECHNOLOGY

Oral fast dissolving tablet containing moringa oleifera essential oil

PendingCN122097468AIncrease relative volatilityReduce volatilityDigestive systemPill deliveryCarboxymethyl starchMoringa pterygosperma
The application provides an oral instant tablet containing Morinda citrifolia oil, which comprises the following components in parts by mass: Morinda citrifolia oil microemulsion 10 parts, carrier 30-40 parts, coating material 2-4 parts, and disintegrating agent 2-5 parts. The coating material is selected from Aeroperl and / or Sylysia; the carrier is selected from one or more of microcrystalline cellulose MCC PH101, microcrystalline cellulose MCC PH102, starch and lactose; and the disintegrating agent is selected from carboxymethyl starch sodium and / or low-substituted hydroxypropyl cellulose. The microemulsification technology is used to wrap the essential oil to reduce the volatilization of the essential oil; the microemulsion is made into a tablet to cover the acidity, increase the compliance of the public, and realize the form change of the Morinda citrifolia oil microemulsion from liquid to solid. The application studies and prepares the oral instant tablet containing Morinda citrifolia oil, which not only solves the inherent defects of traditional dosage forms, but also provides a more convenient taking mode compared with common tablets.
Owner:TROPICAL CORP STRAIN RESOURCE INST CHINESE ACAD OF TROPICAL AGRI SCI

Construction method of tumor three-dimensional motion trajectory prediction model and prediction system

This invention belongs to the field of medical signal processing technology, specifically a method and prediction system for constructing a three-dimensional tumor motion trajectory prediction model. It involves collecting temporal data of point clouds from the human chest and abdomen, as well as temporal location information of the tumor, and establishing a unified spatial coordinate system. The temporal data of the point clouds are divided into n time periods of total duration T1, and the temporal location information of the tumor is divided into n time periods of total duration T2, resulting in n training samples. The point clouds of the training samples are further divided into several pseudo-voxel sub-blocks according to the human projection plane, and K pseudo-voxel sub-blocks are selected based on motion saliency to obtain the temporal feature vector of the tumor motion. The temporal feature vector of the tumor three-dimensional motion trajectory prediction is used as input, and the corresponding tumor temporal location information is used as output to train an attention-enhanced dilated convolutional prediction network. This invention enables high-precision, non-invasive prediction of the three-dimensional tumor motion trajectory.
Owner:HUAZHONG UNIV OF SCI & TECH

A composite probiotic paste and a preparation method and application thereof

The present application provides a kind of complex probiotic paste, which combines Enterococcus faecalis, Saccharomyces cerevisiae and vitamin B 12 Producing lactic acid bacteria of canine source, adds prebiotics, flavoring substances and auxiliary substances such as paste matrix preparation.In the paste, the viable count of Enterococcus faecalis, Saccharomyces cerevisiae and lactic acid bacteria is 1-2:1-2:1-8;Paste matrix includes fructooligosaccharide 0.5-3%, psyllium husk powder 0.1-2%, goat milk powder 2-8%, chicken liver powder 1-5%, potassium sorbate 0.5-2%, xanthan gum 1-4%, and the balance is water.The above-mentioned complex probiotic paste can be stably stored for 56 days at 4 DEG C and normal temperature dry place, has good storage stability, good safety, and can adjust intestinal flora and increase the content of intestinal lactic acid bacteria.The above-mentioned complex probiotic paste has good palatability and oral tolerance for pets such as dogs and cats, and has good therapeutic effect on DSS-induced chronic enteritis diarrhea and vitamin B 12 Deficiency.
Owner:YALUT FOOD (ANHUI) CO LTD +1

Use of echinocandin and rifampin in the preparation of synergistic anti-tuberculosis drugs

The application discloses application of ecurin and rifampicin in preparation of a synergistic anti-tuberculosis drug, and belongs to the technical field of anti-tuberculosis drugs. The core of the application is that ecurin and rifampicin are used in combination, the bactericidal activity of rifampicin is significantly enhanced, the minimum inhibitory concentration of rifampicin is reduced, and the development of drug resistance of Mycobacterium tuberculosis is effectively inhibited. The application further provides a pharmaceutical preparation and a medicine box containing the two active ingredients. The combined application scheme can reduce the clinical dosage of rifampicin, thereby reducing the adverse reactions such as hepatotoxicity of rifampicin, and is suitable for the treatment of sensitive and rifampicin-resistant tuberculosis, and has important clinical value and application prospect.
Owner:ZHEJIANG UNIV

Spherical tablet

The utility model provides a spherical tablet, and belongs to the field of pharmaceutical preparations. The spherical tablet comprises an upper hemisphere, a lower hemisphere and a middle belt, and the middle belt is located in the middle of the spherical tablet and is in a belt shape with the same thickness. The upper hemisphere and the lower hemisphere are located on the two end faces of the middle belt, and the two hemispheres are the same in size and shape. The diameter of the middle zone is larger than the diameter of the hemisphere, the diameter of the hemisphere of an upper stamping die and the diameter of the hemisphere of a lower stamping die of a tablet pressing die adopted when the spherical tablet is pressed ranges from 6.5 mm to 10 mm, and the ratio of the arc depth to the diameter of the hemisphere is (0.2-0.4): 1. The spherical tablet is small in size, easy to swallow, high in drug loading capacity and less in taking quantity; and the tablet has the advantages of good compressibility, good hardness, strong shock resistance and wear resistance, small tablet weight difference, facilitation of later coating and other operations, and good uniformity and reproducibility.
Owner:JIANGXI KERUI PHARM CO LTD

Methods, devices, equipment, and media for monitoring high physiological stress based on rPPG

PendingCN122136004APreserve key physiological informationSolve the problem of unreliable judgmentHealth-index calculationBiological modelsVideo sequenceNetwork model
This invention discloses a method, device, equipment, and medium for monitoring high physiological stress based on rPPG. First, a video sequence containing the user's face is acquired, and the region of interest (ROI) sequence is extracted and input into a deep learning network model. A spatiotemporal encoder extracts preliminary spatiotemporal physiological feature sequences from these sequences. Then, relying on an adaptive frequency-aware decoder, multi-scale parallel processing and dynamic feature fusion are performed on these preliminary spatiotemporal physiological feature sequences to output feature representations of abnormal high-frequency rhythmic events. Finally, a state determiner, combined with the abnormal high-frequency rhythmic event identification results, directly outputs a binary classification result indicating whether the user is in a state of high physiological stress. This invention effectively solves the problem of abnormal high-frequency rhythmic signal loss caused by existing fixed filters, achieving high-precision identification of abnormal high-frequency rhythmic events and accurately determining the user's state of high physiological stress.
Owner:ZHEJIANG WEIBANG EDUCATION TECH CO LTD

Intelligent guidance system and method for shoulder pain rehabilitation

The invention discloses an intelligent guidance system and method for shoulder pain rehabilitation, and belongs to the technical field of health information. According to the method, a continuous image sequence of the upper body of a user is obtained, real-time unmarked motion data of the user is generated based on a human body topology model and an optical flow field analysis method, and the unmarked motion data comprises a personal digital skeleton formed by joint angle estimation values and a force grading estimation value. According to the invention, non-interference and personalized rehabilitation monitoring and guiding are realized, the constraint that a physical sensor must be worn in traditional rehabilitation monitoring is eliminated by adopting a pure visual unmarked motion capture technology, and a patient is allowed to train in a completely natural state, so that the comfort and rehabilitation experience of the user are greatly improved, and the rehabilitation effect of the patient is improved. A high-quality data basis is provided for subsequent personalized guidance, and the willingness and compliance of the patient insisting in rehabilitation for a long time are effectively enhanced.
Owner:WOMEN & CHILDRENS MEDICAL CENTER AFFILIATED WITH GUANGZHOU MEDICAL UNIVERSITY

Astaxanthin liposome-coating probiotic composite system based on interface free radical quenching and bidirectional coupling mechanism and application of astaxanthin liposome-coating probiotic composite system in oxidative stress protection

The invention discloses an astaxanthin liposome-coating probiotic compound system based on an interface free radical quenching and bidirectional coupling mechanism and application of the astaxanthin liposome-coating probiotic compound system in oxidative stress protection, and belongs to the technical field of biological medicines and probiotic preparations. According to the preparation method, probiotics with an iron ion mediated sodium alginate-guar gum coating are constructed, and the probiotics and astaxanthin nano-liposomes form an interface protection layer in a hydrogen peroxide stress microenvironment. Wherein astaxanthin protects the key enzyme activity of a thallus energy metabolism pathway, and the thallus continuously consumes a hydrogen peroxide substrate in the environment through an enzyme system of the thallus. According to the composite system disclosed by the invention, under the condition of no chemical coupling, synergistic enhancement of antioxidant defense and thallus activity can be realized through physical blending, the survival rate and colonization ability of probiotics in gastrointestinal stress are remarkably improved, and an innovative solution is provided for targeted intervention of inflammatory bowel diseases and development of functional probiotic preparations.
Owner:OCEAN UNIV OF CHINA

Lower limb non-weight-bearing state rehabilitation brace

The utility model discloses a lower limbs non -weight bearing state rehabilitation brace, including two supports, the support includes the thigh support pole and shank support pole, the thigh support pole is connected with the shank support pole through being equipped with the swivel base component between, one end of the thigh support pole is connected with the connecting rod through the swivel base component, the connecting rod top is equipped with fixed block, one side of fixed block is equipped with waist binding subassembly, the both sides of two thigh support poles and the both sides of two shank support poles are equipped with leg binding subassembly. The utility model discloses a lower limbs non -weight bearing state rehabilitation brace compares with prior art, can adapt to the patient of different height leg length and different waistline, and the wearing is convenient and comfortable, and the brace is bound through the waist, effectively disperses the body weight, can elevate whole lower limbs, alleviates the burden of the affected limb, especially applicable to the fracture serious, postoperative early rehabilitation or acute ligament injury patient, helps to reduce the force of the affected limb, prevents the disease aggravation.
Owner:THE FIRST AFFILIATED HOSPITAL OF SHANTOU UNIV MEDICAL COLLEGE

Sustained-release composition containing azelaic acid composite liposome and application of sustained-release composition in acne treatment and skin repair

PendingCN121926818AHas a comprehensive improvement effectAchieve multi-target synergistic treatmentCosmetic preparationsAntipyreticCholesterolSkin repair
The invention relates to the technical field of skin care, and discloses a sustained-release composition containing azelaic acid composite lipidosome and application of the sustained-release composition in acne treatment and skin repair. Comprising a composite liposome, an encapsulated active component and a dispersion medium, the composite liposome is composed of a lipid bilayer, the lipid bilayer comprises phospholipid, cholesterol and pegylated phospholipid, and the phospholipid is a mixture of hydrogenated soybean phospholipid and dipalmitoyl phosphatidylcholine; the encapsulated active component comprises a fat-soluble component and a water-soluble component; the water-soluble components comprise a hamamelis virginiana leaf water extract and a herba portulacae extract; the dispersion medium is a phosphate buffer solution; by optimizing lipid composition, introducing surface modification and constructing a multi-layer release system, the invention aims to synergistically exert multiple effects of antibiosis, anti-inflammation, cutin regulation, red fading, repair and the like, and provides an efficient, mild and integrated solution for acne and sequelae skin problems thereof.
Owner:XINCHANG YUHONG PHARMACEUTICAL TECHNOLOGY CO LTD

Tensioning integral bionic robot

The utility model relates to the technical field of biomimetic robots, in particular to a tensegrity biomimetic robot which comprises a first pressing rod, a second pressing rod, a third pressing rod, a fourth pressing rod, a fifth pressing rod, a sixth pressing rod, a plurality of drivers and a controller, the controller is located in the middle of a geometry formed by the pressing rods and electrically connected with the drivers, and inhaul cable assemblies are further installed between the drivers. According to the bionic robot, various forms can be changed, and the adaptability of the bionic robot is improved.
Owner:刘沁阳