891 results about "Binding properties" patented technology

A unique method is disclosed for identifying and replacing immunoglobulin surface amino acid residues which converts the antigenicity of a first mammalian species to that of a second mammalian species. The method will simultaneously change immunogenicity and strictly preserve ligind binding properties. The judicious replacement of exterior amino acid residues has no effect on the ligind binding properties but greatly alters immunogenicity.

Single-molecule selection methods are provided for identifying target-binding molecules from diverse sequence and shape libraries. Complexes and imprints of selected target-binding molecules are also provided. The subject selection methods are used to identify oligonucleotide and nonnucleotide molecules with desirable properties for use in pharmaceuticals, drug discovery, drug delivery, diagnostics, medical devices, cosmetics, agriculture, environmental remediation, smart materials, packaging, microelectronics and nanofabrication. Single oligonucleotide molecules with desirable binding properties are selected from diverse sequence libraries and identified by amplification and sequencing. Alternatively, selected oligonucleotide molecules are identified by sequencing without amplification. Nonnucleotide molecules with desirable properties are identified by single-molecule selection from libraries of conjugated molecules or nucleotide-encoded nonnucleotide molecules. Alternatively, target-specific nonnucleotide molecules are prepared by imprinting selected oligonucleotide molecules into nonnucleotide molecular media. Complexes and imprints of molecules identified by single-molecule selection are shown to have broad utility as drugs, prodrugs, drug delivery systems, willfully reversible cosmetics, diagnostic reagents, sensors, transducers, actuators, adhesives, adherents and novel multimolecular devices.

The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.

Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.

The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.

The present invention relates to a biodegradable and thermosensitive poly(organophosphazene) with a functional group, a preparation method thereof, and a use thereof for delivery of bioactive substances. According to the present invention, poly(organophosphazene) is a phosphagen-based polymer showing biodegradability, thermosensitivity, and sol-gel phase transition depending on temperature change, whereby when administered into a living body with bioactive substances such as drugs, the poly(organophosphazene) forms a gel-phase at body temperature to be capable of controlled release of the bioactive substances. Further, the poly(organophosphazene) has functional groups to chemically bind with bioactive substances through an ionic bond, covalent bond, or coordinate covalent bond to be capable of a sustained release of the bioactive substances due to its good binding property. Therefore, the poly(organophosphazene) is useful as a delivery material for bioactive substances.

Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.

A unique method is disclosed for identifying and replacing immunoglobulin surface amino acid residues which converts the antigenicity of a first mammalian species to that of a second mammalian species. The method will simultaneously change immunogenicity and strictly preserve ligind binding properties. The judicious replacement of exterior amino acid residues has no effect on the ligind binding properties but greatly alters immunogenicity.

The present invention relates to Fc variants with optimized Fc ligand binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc ligand binding properties, and methods for using same.

Single-molecule selection methods are provided for identifying target-binding molecules from diverse sequence and shape libraries. Complexes and imprints of selected target-binding molecules are also provided. The subject selection methods are used to identify oligonucleotide and nonnucleotide molecules with desirable properties for use in pharmaceuticals, drug discovery, drug delivery, diagnostics, medical devices, cosmetics, agriculture, environmental remediation, smart materials, packaging, microelectronics and nanofabrication. Single oligonucleotide molecules with desirable binding properties are selected from diverse sequence libraries and identified by amplification and sequencing. Alternatively, selected oligonucleotide molecules are identified by sequencing without amplification. Nonnucleotide molecules with desirable properties are identified by single-molecule selection from libraries of conjugated molecules or nucleotide-encoded nonnucleotide molecules. Alternatively, target-specific nonnucleotide molecules are prepared by imprinting selected oligonucleotide molecules into nonnucleotide molecular media. Complexes and imprints of molecules identified by single-molecule selection are shown to have broad utility as drugs, prodrugs, drug delivery systems, willfully reversible cosmetics, diagnostic reagents, sensors, transducers, actuators, adhesives, adherents and novel multimolecular devices.

Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.

The invention discloses an aluminum-plastic membrane used for packaging the lithium battery. The aluminum-plastic membrane mainly comprises a protective layer, an aluminum foil layer and a heat sealing layer, wherein the protective layer is bound and combined with the aluminum foil layer through a glue layer, the heat sealing layer is bound and combined with the aluminum foil layer through a glue layer; before the binding and combining, the plasma technology is adopted to perform surface grafting treatment to the surfaces of the protective layer, the aluminum foil layer and the heat sealing layer; and then the protective layer and the aluminum foil layer are separately combined with the both sides of one glue layer through hot-pressing, and the aluminum foil layer and the heat sealing layer are are separately combined with the both sides of one glue layer through hot-pressing. The aluminum-plastic membrane has higher chemical resistance, moisture-proof property, oxygen-isolating property and packaging-binding property, also has explosion-proof property and is suitable for the soft package lithium battery.

The present invention provides antibodies and antigen-binding fragments thereof that specifically bind proprotein convertase subtilisin / kexin-9 (PCSK9) with greater affinity at neutral pH than at acidic pH. The antibodies of the invention may possess one or more amino acid changes as compared to antibodies that do not exhibit pH-dependent binding properties. For example, the present invention includes anti-PCSK9 antibodies which possess one or more histidine substitutions in one or more complementarity determining regions. The antibodies of the invention, with pH-dependent binding properties, remain in circulation and exhibit cholesterol lowering activity for prolonged periods of time in animal subjects as compared to anti-PCSK9 antibodies that do not exhibit pH-dependent binding properties. The antibodies of the invention are therefore useful for treating diseases and disorders related to elevated HDL cholesterol, wherein the antibodies of the invention can be administered to a patient at a lower dose and / or with less frequent dosing as compared to antibodies that do not exhibit pH-dependent binding properties.

The invention discloses a thermoplastic resin-based carbon fiber composite and a preparation method thereof. The thermoplastic resin-based carbon fiber composite comprises the following components in percentage by volume: 50 to 70 percent of carbon fibers and 30 to 50 percent of thermoplastic resin. In the preparation method, according to rheological properties of the thermoplastic resin, the thermoplastic resin-based carbon fiber composite with good interface binding property is prepared by utilizing hot-roller hot-pressing continuous equipment and adjusting process conditions such as machining temperature, machining pressure, machining time and the like. Compared with the prior art, the thermoplastic resin-based carbon fiber composite has the advantages of simple structure, good interface binding property, high impact resistance and recycling property; and the preparation method can realize the uniform distribution of the carbon fibers and the thermoplastic resin and ensure the carbon fibers are immersed by the thermoplastic resin completely, so that the defect of the conventional method is overcome.

A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous phage M13. The gene fusion is mutated to form a library of structurally related fusion proteins that are expressed in low quantity on the surface of a phagemid particle. Biological selection and screening are employed to identify novel ligands useful as drug candidates. Disclosed are preferred phagemid expression vectors and selected human growth hormone variants.

A polymer assisted deposition process for deposition of metal oxide films is presented. The process includes solutions of one or more metal precursor and soluble polymers having binding properties for the one or more metal precursor. After a coating operation, the resultant coating is heated at high temperatures to yield metal oxide films. Such films can be epitaxial in structure and can be of optical quality. The process can be organic solvent-free.

A binder for an electric double layer capacitor electrode, which includes a copolymer (A) including monomer units derived from at least one compound (a) represented by the following general formula (1):CH2═CR1—COOR2  (1)wherein R1 represents a hydrogen atom or a methyl group, and R2 represents an alkyl group or a cycloalkyl group, the glass transition temperature obtained by homopolymerizing the compound (a) being less than 0° C., and monomer units derived from at least one compound (b) selected from acrylic acid alkyl esters, methacrylic acid alkyl esters, aromatic vinyl compounds, and α,β-unsaturated nitrile compounds, the glass transition temperature obtained by homopolymerizing the compound (b) being 0° C. or higher, wherein the total content of the monomer units derived from the compound (a) and those derived from the compound (b) is 90% or more by weight per 100% of the whole copolymer (A), and the glass transition temperature of the copolymer (A) is 10° C. or lower, which binder is excellent in smoothness, crack resistance and binding properties.

The present invention provides a nonmetallic twist tie in which the function inherent to the twist tie is of course available and the twist tie is easily made into a shape of being wound in a bundle with no slipping down of the tie into gap, no torsion of the tie itself, no curl, no twining and tangling of ties and no loosening or disjoining from a reel whereby its drawing-out from the wound shape is able to be carried out smoothly. The nonmetallic twist tie having a core part and a wing part constituted from a non-halogenous material is characterized in that (1) a shape having a total width is 1.5 to 20.0 mm, the average thickness of the wing part is 0.02 to 0.20 mm and the maximum thickness of the core part is 0.04- to 0.30-fold of the total width, (2) a binding property where a torsion strength is 5.0 to 15 N, (3) a rigidity where a tensile elasticity is 5,000 to 30,000 Mpa, (4) a property of forming a fixed shape where the property is 90% or more and a property of retaining a fixed shape where the rate of retaining the fixed shape is 70 to 95%, and (5) a drawing-out property where a degree of curving to the drawing-out direction is 10° or less and a curl radius to the winding direction retains the range of 50 to 200 mm.

The invention relates to a glass fiberreinforced thermoplastic composite and a continuous fiber-reinforced composite, which are prepared with the following raw materials percentagewise by weight: 35-60 % of resin, 35-60 % of dip treated glass fiber and 0.5-5 % of auxiliary agent. The invention adopts resin and dip treated glass fiber as main raw materials, mixtures of antioxidant, ultraviolet absorbent and light-stability agent as main auxiliary agents, with logical formulations, eliminates the damage to glass fibrous surface caused by twin-screw with continuous fiber-reinforced composite producted by this manufacturing technique, improves product lustrous surface, binding properties between fiberglass and resins by a treatment for glass fibrous surface and mechanical properties of products, protects the materials for long periods from destruction because of addition of various stabilizing agents, and solves the limitation that general materials can not be used for a long time in extreme conditions such as high temperature, high humidity, radiation and so on.

Disclosed is an air purification filter with novel active media that attracts, migrates, binds, and destroys pathogens, including sub-micron pathogens, that are suspended in the air passing through the filter. These properties are incorporated in the micro-fibers comprising the active filter media by several novel methods. One embodiment uses polymers or solgel bound monomers of quaternary ammonium compounds as a biocide with both chemotactic and pathogen membrane lysing properties. Another embodiment uses biocide chemicals blended into the melt before filter fibers are extruded and electret dipole charged. The attracting-binding properties of the embodiments may be enhanced by including electropositive Boehmite nano-fiber strands in the active media, by coating a reversible voltage charged electro-conductive polymer, by the use of supplemental fusing and lysing chemicals, and by optional ion field charging of incoming pathogens.

The present invention is directed to novel nucleic acid molecules and methods for their use. More specifically, the novel nucleic acid molecules of the present invention are capable of tightly and specifically interacting with a target molecule of interest not only through standard Watson-Crick base pairing, but also through additional features which allow the antisense molecules to become topologically “locked” onto the target nucleic acid, thereby imparting improved transcription and translation inhibitory properties.

The invention discloses a lithium-ion battery negative pole piece and a production method. The negative pole piece comprises a first coating which is coated with an active substance, a second coating which is arranged on the surface of the first coating, and a third coating which is arranged on the surface of the second coating, wherein the second coating is a ceramic diaphragm coating, and the thickness of the second coating is 10 to 25 microns; the third coating is a porous polyvinylidene fluoride (PVDF) coating, and the thickness of the third coating is 2 to 6 microns. The lithium-ion battery negative pole piece solves the problems that the ceramic material directly coated on the pole piece drops off easily, high in brittleness and poor in binding property, the lithium dendritic crystal can be avoided in over-charging and over-discharging, the negative pole piece can be prevented from being separated from stripping caused by inflation in the charging-discharging process, so that the safety performance of the lithium battery can be improved.

The invention discloses a bi-component condensed type organic silicon pouring sealant as well as a preparation method and an application thereof. The bi-component condensed type organic silicon pouring sealant consists of a component A and a component B, wherein the component A comprises the following raw materials in parts by weight: 350-500 parts of linear hydroxyl-terminated polydimethylsiloxane, 300-600 parts of filler, 50-150 parts of base gum and 0.1-5 parts of a deep curing agent; the component B comprises the following raw materials in parts by weight: 200-500 parts of a cross linker, 300-800 parts of a plasticizer, 50-100 parts of a coupling agent and 0.5-2 parts of a catalyst; and the weight ratio of the component A to the component B is (100:5) to (100:20). Under an airtight condition, the sealant, which is aged for 30d at 150 DEG C, is free from the abnormal phenomenons of peeling off, pores, failure, reduction and the like, and the sealant can completely meet the requirements of an LED driving power supply or a waterproof power supply on waterproofing and binding properties.

A polymer assisted deposition process for deposition of metal oxide films and the like is presented. The process includes solutions of one or more metal precursor and soluble polymers having binding properties for the one or more metal precursor. After a coating operation, the resultant coating is heated at high temperatures to yield metal oxide films and the like. Such films can be epitaxial in structure and can be of optical quality. The process can be organic solvent-free.

The invention relates to a method for preparing a high polymerization degree bacterial cellulose fiber. The method comprises the following steps: (1) dissolving the bacterial cellulose in solvent to prepare bacterial cellulose solution with mass fraction of 1-30 percent, filtering and standing the solution for deaeration, thus obtaining spinning solution; (2) forming the spinning solution in the step (1) by solidifying after the solution is sprayed through a spinneret orifice, and preparing a finished product after several conventional processes, such as stretching, washing, shaping and drying. The preparation method is simple and is applicable to industrial production; compared with other cellulose fibers, the bacterial cellulose fiber has high rupture strength and module reaching the level of high-tensile industrial yarn, and has the advantages of good biocompatibility, odegradability, hydrophilicity and binding property with rubber.

The invention relates to the tire manufacture field, especially to a tire apex composition for improving a bond system and its preparation method and application. The tire apex composition for improving the bond system is formed by the mixing of the following ingredients of: by weight, 70-100 parts of natural rubber, 0-30 parts of styrene-butadiene rubber, 55-75 parts of carbon black, 1.0-4.0 parts of resorcinol, 0.2-3.0 parts of cobalt decanoate, 3-8 parts of a methylene donator adhesive, 0-20 parts of white carbon black, 3-8 parts of a vulcanizing agent and a sulfuration promoter and other processing auxiliary agents. The tire apex composition for improving a bond system obviously raises modulus and binding property, decreases heat generation, minimizes modulus loss at high temperature,and simultaneously reduces formula cost. By employing BTR tires under the precondition of unchanged structure, the hard apex strength and hardness can be guaranteed not to be decreased, the modulus is substantially increased, the bond performance between the apex and steel wires / steel wire cords is remarkably improved, and the anti-destroy performance of tire bead positions is raised.

The invention provides engineered heteromultimeric protein complexes constructed using one, two, or three tethers and methods for making, using, and purifying such complexes, such as antibodies with different binding properties.

Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer. Surface coatings are also described having both non-specific protein binding properties combined with functional groups for specific binding activity thereby providing surface coating that specifically recognize target proteins but limit binding to non-specific protein.

A binder for electrode of lithium ion secondary battery, comprised of a copolymer composed of 15 to 80 weight % of units from ethylenically unsaturated monomer (A) whose homopolymerization yields a polymer soluble in N-methylpyrrolidone (NMP) and 20 to 85 weight % of units from ethylenically unsaturated monomer (B) whose homopolymerization yields a polymer insoluble in NMP, which copolymer exhibits a swelling degree of 4 or below, in an electrolyte obtained by dissolving LiPF6 in the concentration of 1 mol / liter into a solvent of 1:2 (volume ratio at 20° C.) mixture of ethylene carbonate (EC) and diethyl carbonate (DEC) . This binder for electrode of lithium ion secondary battery enables obtaining an electrode having a flexible electrode layer excelling in binding properties with industrial advantage.