31 results about "Binding properties" patented technology

The purpose of the present disclosure is to provide a molecule that shows different binding properties between a full capsid and an empty capsid of AAV. An antibody is provided that has a higher binding ability to an AAV empty capsid than to an AAV full capsid, under a condition (I) of pH 7.4 or a condition (II) of pH 3.0.

This invention discloses a lactide-Nisin solid dispersion and its preparation method. The method includes preparing a mixture of lactide and a hydrophobic solvent; dispersing Nisin in the mixture obtained in the previous step to obtain a multi-component mixture; and cold-treating the multi-component mixture to obtain a solid mixture containing lactide and Nisin. This invention fully utilizes the binding properties of lactide and Nisin, effectively enhancing the stability of Nisin in complex environments, further expanding the application potential of the prepared antibacterial agent, and providing a new approach for developing multifunctional green food preservatives.

Due to the constituent components of the cell walls of filamentous fungi, the texture when eating a filamentous fungus body resembles a paper-like texture, and applications other than meat analogs are limited. Additionally, filamentous fungus bodies have characteristics of absorbing water but also readily releasing water, and having no binding property between mycelia, and thus even when a crushing treatment is performed, it has been difficult to process the result into foodstuffs that have a feeling of unity due only to a filamentous fungus culture product, or into foodstuffs that have uniform and smooth paste-like physical properties. This edible filamentous fungus body having an adjusted texture can be provided by treating a filamentous fungus body with a cell wall degrading enzyme.

The invention provides a Trop2-combined nano antibody as well as a product and application thereof, and relates to the technical field of antibodies. The invention discloses a nano antibody specifically binding to Trop2 protein, and a VHH sequence and a corresponding CDR sequence of the nano antibody. The nano antibody has the capability of high-affinity binding to target protein, and the nano antibody subjected to humanized modification still keeps the high-affinity binding characteristic.

An water-in-oil emulsion composition that enables imparting binding properties and juiciness to a meat substitute processed product comprising plant raw material. The water-in-oil emulsion composition for use in a meat substitute processed product comprising plant raw material includes an emulsifier A, and an emulsifier B and / or an emulsifier C. The emulsifier A is selected from the group consisting of a polyglycerin-condensed ricinoleic acid ester, a glycerin fatty acid ester, a sucrose fatty acid ester, and a lecithin, and has an HLB of 9.0 or less. The emulsifier B is a fatty acid ester and has saturated a fatty acid as a constituent fatty acid. The emulsifier C is a fatty acid ester and has only an unsaturated fatty acid as constituent a fatty acid.

The invention provides an anti-TIGIT antibody and IL-15 fusion protein and application thereof, and specifically, the fusion protein comprises a first binding region having IL-15 receptor binding activity, a second binding region having IL-15 receptor binding activity, and a third binding region having IL-15 receptor binding activity; and a second binding region, the second binding region having a TIGIT binding activity. The fusion protein can be combined with TIGIT and IL-15 receptor protein molecules, an anti-TIGIT antibody relieves an immunosuppressive signal of TIGIT, the fusion protein is promoted to be enriched into TIGIT high-expression cells and tissues by utilizing the targeted combination characteristic of the anti-TIGIT antibody, meanwhile, IL-15 promotes proliferation and maintenance of immune cells and enhances the anti-tumor immune function, and the fusion protein has good clinical application value.

The present invention relates to core-shell particles (or a core-shell particle-type binder), a composition comprising the core-shell particles (or the core-shell particle-type binder), or an electrode manufactured from the composition, the core-shell particles having a perfluorinated resin core, which comprises a perfluorinated polymer, and a resin shell layer, which comprises an acrylic polymer, wherein the core-shell particles are prepared by emulsion-polymerizing an acrylic monomer to the perfluorinated resin core by using, as an emulsifier, a polyethylene glycol ether having an alkyl group of C8 or greater, which is substituted with at least one alkyl of chemical formula 1, and the acrylic monomer comprises (a) methyl methacrylate (MMA), (b) methacrylic acid (MAA) or acrylic acid (AA), and (c) a C2-C6 alkyl (meth)acrylate.

The present application relates to chimeric DNA polymerases and methods of making the same. The chimeric DNA polymerases comprise 2-8, e.g., 3, domains or segments derived from different polymerases. The chimeric DNA polymerases of the present application have improved properties, e.g., superior extension properties, superior DNA binding properties, superior proofreading activity, superior fidelity, faster amplification speed, superior tolerance to inhibitors, superior long fragment amplification ability, etc.

Provided is a binder for an electrode of a lithium secondary battery, the binder having excellent binding properties, being capable of reducing electrode swelling caused by charge / discharge, and bringing about excellent charge / discharge cycling characteristics.　A binder for an electrode of a lithium secondary battery according to an embodiment comprises an aqueous dispersion of a polyurethane obtained by reacting (A) an aliphatic polyisocyanate and / or an alicyclic polyisocyanate, (B) one or more polyols, (C) a compound having two or more hydroxyl groups and a carboxy group, and (D) a chain extender. The (B) component includes a hydrogenated polybutadiene polyol. The molar ratio (NCO / OH) of the isocyanate groups of the (A) component to the hydroxyl groups of the (B) component and (C) component is 1.15 or higher but less than 1.35.

Provided are: a peptide having good binding properties with isovaleric acid; and a composition for isovaleric acid measurement and an odor sensor each using the peptide. The peptide comprises an amino acid sequence represented by any one of SEQ ID NOS: 1-13. The composition for isovaleric acid measurement and the odor sensor contain a peptide comprising an amino acid sequence represented by any one of SEQ ID NOS: 1-13.

This prediction method to be executed by a computer includes a prediction step (S13) in which biological properties of a test substance are predicted on the basis of physicochemical properties based on at least the electrical charge or the hydrophobicity of the test substance. The biological properties can be at least one property selected from the group consisting of the immunogenicity, the pharmacokinetics, and the nonspecific binding properties of the test substance. The physicochemical properties can be further based on a dipole moment. The physicochemical properties can also be based on at least electrical charge distribution or hydrophobicity distribution. The physicochemical properties can also be based on at least deviation in electrical charge distribution or deviation in hydrophobicity distribution. The electrical charge distribution can also be based on electrical charge and a dipole moment, and the hydrophobicity distribution can also be based on hydrophobicity and a dipole moment.

A chimera DNA polymerase and a preparation method therefor. The chimera DNA polymerase contains 2-8 (for example 3) domains or segments derived from different polymerases. The chimera DNA polymerase has improved properties such as a better extension characteristic, a better DNA binding characteristic, a better corrective activity, a better fidelity, a higher amplification speed, a better tolerance to an inhibitor, and a higher long fragment amplification capability.

The present invention relates to a method for screening engineered antibody Fc regions having modified Fc receptor binding properties, the method comprising the steps of: (a) providing a plurality of cells displaying engineered antibody Fc regions on their cell surface, preferably wherein each cell comprised in the plurality of cells displays an engineered antibody Fc region comprising at least one mutation; (b) contacting the cells in step (a) with an Fc receptor; (c) separating cells that have been contacted with the Fc receptor in step (b) into two or more cell populations according to their ability to bind to the Fc receptor, preferably wherein the ability of an engineered antibody Fc region to bind to the Fc receptor is determined by comparison with a reference antibody Fc region; and (d) sequencing cells from at least one of the populations obtained in step (c), preferably to identify mutations in the engineered antibody Fc region that (i) confer improved binding to the Fc receptor, (ii) do not affect binding to the Fc receptor, and / or (iii) confer reduced binding to the Fc receptor. Further provided herein are methods for predicting the Fc receptor binding properties of an engineered antibody Fc region, as well as methods for generating an engineered antibody Fc region having desired Fc receptor binding properties

According to various aspects, the present invention provides a method of delivering a plurality of sample solutions to a sensor surface (102) for analysis. It can additionally, or alternatively, provide systems and methods for enabling improved investigation of analyte behaviours. The sensor (102) may, for example, be used to determine kinetic binding properties of analytes (such as proteins) to surface bound ligands. In one aspect, a method comprises: a) introducing (902) a first sample solution (502) into a first channel (506), the first channel (506) configured to deliver sample solution to the sensor surface (102); b) introducing (904) a second sample solution (504) into the first channel (506); c) flowing (906) the first sample solution and the second sample solution through the first channel (506) and over the sensor surface (102); and d) detecting (912) the presence or absence of binding of analyte from at least one of the sample solutions (502, 504) at the sensor surface (102), wherein no running buffer solution is passed over the sensor surface (102) throughout steps a)-d).

This invention provides a method for producing modified milk protein-regenerated cellulose fibers that improves the stability of milk proteins and enhances the binding properties between milk proteins and fibers. [Solution] The present invention involves condensing the N-terminus and C-terminus of a whey protein peptide to form a cyclic milk protein having an amide ring structure, and further esterifying some of its hydroxyl groups with acryloyl chloride to obtain a modified cyclic milk protein having acrylate groups. This modified protein is grafted onto cellulose to produce regenerated cellulose fibers. According to the present invention, the chemical stability of the protein and its binding affinity to cellulose are improved, the protein content in the fiber can be maintained at a high level of 5.54 to 7.16%, and a milk protein-modified regenerated cellulose fiber with excellent dimensional stability and a shrinkage rate of less than 3% can be obtained.

This invention discloses a modified nanobody with pH-dependent binding characteristics to the S-RBD of the original and mutant strains of SARS-CoV-2 and its potential applications, belonging to the field of biotechnology. The affinity purification packing material prepared based on any one of the nanobodies described in SEQ ID NO. 1-3 provided by this invention directly targets the S-RBD of wild-type and mutant SARS-CoV-2, achieving one-step purification of the target protein without a tag. The purified target protein has extremely high purity, binds to the target protein at pH 7.5, and is fully eluted at pH 5.0. The affinity purification packing material for the S-RBD nanobody can be regenerated at pH 4.5. Therefore, the nanobodies MNb-11, MNb-13, and MNb-14 provided by this invention have wide applications in the production, purification, binding, and / or dissociation of the S-RBD and S protein of wild-type and mutant SARS-CoV-2.

The present invention provides a binder that is for a secondary battery electrode, that exhibits excellent binding properties, and that is thus capable of improving the cycle characteristics of a secondary battery. Additionally, the present invention provides: a composition which is for a secondary battery electrode mixture layer and which comprises the binder; a secondary battery electrode which is obtained using the composition; and a secondary battery.　Provided is a binder for a secondary battery electrode, said binder comprising a carboxyl group-containing non-crosslinked polymer or a salt thereof, wherein: the carboxyl group-containing non-crosslinked polymer includes a structural unit derived from an ethylenically unsaturated carboxylic acid monomer (hereinafter referred to as "monomer (a)") and a structural unit derived from a nitrile group-containing ethylenically unsaturated monomer (hereinafter referred to as "monomer (b)"); and a value (X) of the carboxyl group-containing non-crosslinked polymer or salt thereof, as calculated using formula (1), is 0.050-0.500.

The present invention addresses the problem of providing a cyclic peptide or a salt thereof and a cyclic peptide complex or a salt thereof having excellent binding properties with an FGFR protein, and of providing a culture medium composition, a purification material, a labeling material, a cell control material, and an integration material using the cyclic peptide or the salt thereof and the cyclic peptide complex or the salt thereof. According to the present invention, provided is a cyclic peptide or a salt thereof, which comprises an amino acid sequence represented by X1-Xm-X2-Xn-X3 and comprises a cyclization part that is cyclized by a covalent bond, the cyclization part comprising a structure represented by formula (2), X1 represents a glutamine residue or a histidine residue, Xm represents a peptide residue comprising 2 to 4 arbitrary amino acid residues, and Xn represents a peptide residue comprising 2 to 4 arbitrary amino acid residues. X2 represents an alanine residue, a leucine residue, an isoleucine residue, a phenylalanine residue, a tyrosine residue, a tryptophan residue, a glutamine residue, a serine residue, a threonine residue, an asparagine residue, a glutamic acid residue, an arginine residue, or a histidine residue, Xn represents an amino acid residue or a peptide residue comprising any one to three amino acid residues, x3 represents an amino acid residue containing an aromatic residue in a side chain, Z1 and Z2 each independently represent a linking group, and m represents an integer of 1-10.

Methods for making, identifying, isolating and / or making binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Exemplary binding proteins specific to small molecules are also provided.

To provide a binder for a metal-ion secondary battery that exhibits excellent binding properties with an active material and excellent adhesion to a current collector and that increases Coulombic efficiency while suppressing decomposition of an electrolytic solution.SOLUTION: The binder includes a fumaric-acid-based polymer having a repeating unit represented by Formula (I) and a nitrogen-cation-containing polymer having a repeating unit represented by Formula (II). (In Formula (I), R1 and R2 independently indicate H or an alkali-metal atom.)SELECTED DRAWING: None

This disclosure provides a multimodal compound generation system and method that simultaneously considers different dimensions of the target protein's characteristics to generate compounds. These compounds exhibit stronger binding properties to the target protein compared to molecules produced by considering only a single dimension in the past. Furthermore, modified compounds can be generated from known compound molecules, and this can be used to train a neural network model to improve the quality of future compound generation. This disclosure also provides a multimodal custom compound generation system that allows users to input desired parameters to produce compounds that meet their expectations.

A method of cyclizing an L-RNA aptamer by modifying the aptamer with a 3′ azide and a 5′ alkyne group and using click chemistry reaction-based method. The cyclized L-RNA aptamers have improved binding properties and favour more in vitro / cell applications. Also disclosed is an L-oligonucleotide aptamer having linked ends.

The invention belongs to the technical field of refractory materials, and discloses a preparation method of stemming with high oxidation resistance and high bonding performance. Through silane coupling agent modification and a 80-100 DEG C temperature-controlled stirring process, the problem that nano silicon carbide is easy to agglomerate is solved, the dispersion uniformity of the nano silicon carbide in a stemming matrix is improved, and the antioxidant efficiency is enhanced. Corundum-titanium calcium aluminate-fused magnesite composite aggregate is innovatively adopted, special drying pretreatment of titanium calcium aluminate is matched, the interface bonding force of the aggregate is improved through a precise dry mixing process, and a high structural stability foundation is laid. A phenolic resin-modified lignin compound system is used for replacing a traditional binder, uniform compounding is achieved through 60-80 DEG C temperature-controlled stirring in a water bath kettle, the bonding strength and the environmental protection property are both considered, and harmful volatilization is reduced. The method is applied to double improvement of oxidation resistance and bonding performance of the blast furnace stemming, and the service life of the stemming is further prolonged.

To provide oil-and-fat-processed starch which has good metal releasability and whose binding property with protein is not impaired.SOLUTION: The oil-processed starch contains ≥ 8.0 pts. mass of water based on 100 pts. mass of the oil-processed starch.SELECTED DRAWING: Figure 1

Bionic prosthetic system reinforced with natural fibers, consisting of: a prosthetic structural body formed from a composite material comprising natural fibers and a polymer resin matrix; the natural fibers include pineapple leaf fibers (PALF) treated with an alkaline solution to improve the binding properties; wherein the polymer resin matrix comprises epoxy resin or an equivalent thermally curable polymer; the prosthetic system is configured to offer joint mobility of up to 180°, a load-bearing capacity of up to 100 kilograms and a lifespan of 5 to 7 years; The system is manufactured using a hand-laying process followed by oven curing, resulting in a lightweight and durable prosthesis with improved mechanical strength and environmental sustainability.

The present invention provides a binder for an electrode of a lithium-ion battery capable of improving the binding property between a current collector and an electrode active material layer while keeping the internal resistance of the lithium-ion battery low.　The present invention provides a binder for an electrode of a lithium-ion battery, which has good binding property between a current collector and an electrode active material layer, has good electrolyte resistance, and has a high capacity retention rate associated with a charge / discharge cycle.　This binder for an electrode of a lithium-ion battery comprises: a core; and core-shell particles including a shell layer positioned outside the core, wherein the core is composed of rubber. The shell layer is composed of a specific shell-forming polymer.

This invention belongs to the field of in vitro diagnostic technology, specifically relating to a quantum dot-based immunochromatographic assay kit for detecting pepsin in saliva and its preparation method. This invention achieves adsorption of impurities in saliva samples by adding a chitosan filter pad to the sample pad of the pepsin assay kit. Simultaneously, utilizing the specific binding properties of proteins such as SPA / SPG, a dual SPA / SPG-mediated signal enhancement system is constructed at the binding pad. The T-line is first modified with SPA / SPG before being loaded with pepsin antibody 2. These improvements significantly enhance the antibody conjugation efficiency of the kit, increase the antibody conjugation efficiency at the T-line, reduce non-specific antibody binding, and significantly improve the signal intensity of the kit, ultimately significantly improving the detection sensitivity and accuracy of the kit.

The present invention provides a binder for an electrode of a lithium-ion battery capable of improving the binding property between a current collector and an electrode active material layer while keeping the internal resistance of the lithium-ion battery low.　The present invention provides a binder for an electrode of a lithium-ion battery, which has good binding property between a current collector and an electrode active material layer, has good electrolyte resistance, and has a high capacity retention rate associated with a charge / discharge cycle.　This binder for an electrode of a lithium-ion battery comprises: a core; and core-shell particles including a shell layer positioned outside the core, wherein the core is composed of rubber. The shell layer is composed of a specific shell-forming polymer.