533 results about "Controlled release" patented technology

The invention discloses a pure bio-based PHA aqueous dispersion as well as a preparation method and application thereof, and belongs to the technical field of pure bio-based polymer aqueous dispersion. According to the dispersion, polyhydroxyalkanoate is used as a unique film forming matter, Pickering solid particles and a natural surfactant are adopted for synergistic stabilization, and a bio-based plasticizer can be selected. The emulsion or slurry with the polyhydroxyalkanoate content of 40-85wt% and the particle size of 0.2-3m is prepared through a melting high-pressure homogenization method, a low-temperature wet grinding method or a solvent replacement method. The coating does not contain petrochemical polymer protective colloid and perfluorinated and polyfluoroalkyl substances, and the bio-based content is greater than or equal to 99%. Due to the excellent stability, rheological property and film-forming property of the modified starch, the modified starch becomes an ideal basic material for constructing a multi-layer programmable controlled release and degradation functional coating system, can be used in the fields of paper-based barrier coatings, adhesives, advanced crop seed coats and the like, realizes excellent barrier, bonding and controlled release properties, meets the industrial compost and repulping property standards, and has wide application prospects. The method has green, environment-friendly and industrial potential.

A multi-pore aroma diffuser device includes an accommodation base and a porous diffuser to be detachably assembled on the accommodation base to replace existing diffuser stones. Through the porous material structure and a liquid storage bottle inside the device, fragrance liquid is continuously provided for the porous diffuser to continuously emit fragrance, and there is no need to rely on electricity or energy-consuming heating to produce fragrance. It has a long service life and slowly and controlled release of fragrance. The porous diffuser is detachably assembled on the accommodation base. The detachable design allows for easy replacement of the liquid storage bottle. It also greatly simplifies the weight and complexity of the overall structure, making it easy to use and conducive to releasing the effectiveness of the fragrance.

The invention discloses a PVA / urea / CC lignocellulose composite mulching film as well as a preparation method and application thereof, and belongs to the technical field of agricultural mulching films. The composite mulching film disclosed by the invention is obtained by adding PVA (Polyvinyl Alcohol) into a corncob lignocellulose HTP-CC dispersion liquid subjected to hydrothermal pretreatment, then sequentially adding glutaraldehyde, urea and glycerol and carrying out cross-linking reaction. The mechanical property of the PUCH mulching film prepared by the invention meets the GB / T35795-2017 standard, and the PUCH mulching film has excellent water vapor barrier property, ultraviolet shielding property, urea controlled release property, heat insulation property and biodegradability. The characteristics not only can promote crop growth, but also can reduce agricultural environmental pollution. Therefore, the PUCH mulching film shows huge potential to replace the traditional plastic mulching film, and has important application prospects in agricultural planting.

The invention discloses a composite curcumin nano pesticide and a preparation method and application thereof.The nano pesticide comprises a carrier and curcumin loaded on the carrier, the carrier is polydopamine-sodium lignin sulfonate, and the polydopamine-sodium lignin sulfonate is formed by polymerizing dopamine hydrochloride on the surface of lignin; the preparation method comprises the following steps: preparing a curcumin solution, adding the polydopamine-sodium lignin sulfonate powder, fully dispersing, slowly stirring under a dark condition until a yellow solution becomes dark red, and removing a solvent to obtain the polydopamine-sodium lignin sulfonate-curcumin. The nano pesticide provided by the invention takes polydopamine-sodium lignin sulfonate as a carrier, so that the drug has pH and photo-thermal response controlled release function, burst release of curcumin is avoided, and the stability and bioavailability of curcumin are improved.

The invention belongs to the technical field of compressed air control, and particularly relates to a compressed air energy storage power station multistage protection and controlled discharge control method and system. Comprising the steps that a compressed air energy storage power station system comprising a discharge bypass and a discharge valve and a safety valve which are arranged on the downstream of the discharge bypass is built; when pressure abnormity occurs, first-stage response is started, operation parameters of the compressed air energy storage power station system are adjusted, or a discharge bypass is started in an overlapped mode, and the pressure abnormity trend is restrained; when the first-stage response cannot restrain pressure abnormity, the second-stage response is started, the opening degree of the release valve is adjusted, and gas release is conducted; and when the second-level response cannot restrain pressure abnormity, third-level response is started, a stepped release sequence is adopted, the opening degree of a release valve is increased, meanwhile, the opening degree of a safety valve is gradually increased to conduct gas release, and finally final release is conducted by triggering a rupture disk. According to the invention, through a stepped control strategy, the defects that a single protection device is single in protection means and easy to over-excite protection are avoided.

The invention belongs to the technical field of medical gel, and particularly relates to modified hydrogel for skin wound healing and a preparation method thereof.The modified hydrogel is prepared from, by weight, 2-5 parts of drug-loaded GDVLNs, 1-2 parts of chitosan, 0.6-1.5 parts of antioxidant, 0.2 part of LAP, 1.5 parts of MA, 18 parts of gel matrix and 100 parts of buffer solution, the drug-loaded GDVLNs prepared from the traditional Chinese medicine active ingredients and the ginseng vesicles have the functions of resisting oxidative stress, promoting angiogenesis, promoting cell proliferation and the like, and the MA modified hydrogel system can realize slow release and controlled release of the drug-loaded GDVLNs and play a long-acting healing promoting role.

The invention relates to the technical field of controlled-release microcapsules, and particularly discloses a pH-responsive mold-targeted controlled-release essence microcapsule for daily chemicals and a preparation method thereof.The preparation method comprises the following steps that S1, chitosan is dissolved with an acid solution, a catalyst and a pH sensitive reagent are added under the protective atmosphere for a reaction, and a pH-responsive graft copolymerization product is obtained through separation and purification; s2, mixing the pH response graft copolymerization product, a cross-linking agent and a mould targeting reagent for reaction, and dialyzing and purifying to obtain a microcapsule wall material; and S3, emulsifying essence by using an emulsifier, and then adding a defoaming agent, the microcapsule wall material, the sodium tripolyphosphate aqueous solution and a pH regulator to prepare the pH-responsive mold-targeted controlled-release essence microcapsule for daily use. The microcapsule integrates specific recognition targeting ability and pH response release ability to mould, and can accurately release natural essence with bacteriostatic and aromatic functions at the mould breeding part of clothes, so that the dual effects of bacteriostasis and aroma retention are realized.

The invention discloses a preparation method of immunoglobulin composite liposome nanoparticles with a controlled release characteristic, and belongs to the field of food nutrition and functional factors. Cholesterol and sitosterol are creatively used as auxiliary supports of a lecithin liposome skeleton, the stability of an immunoglobulin liposome nanoparticle structure is improved, the slow release property in the simulation effect process is improved, and a pH response type hydrogel film formed based on electrostatic crosslinking is prepared from calcium alginate and chitosan. A more stable double-layer shell-core structure is formed, so that the stability of embedded immune globulin molecules in gastric juice is further improved, and fixed-point slow release in small intestines is realized.

The invention relates to a modified superoxide dismutase pH response type nano-liposome and a synergistic anti-photoaging after-sun repair composition capable of achieving accurate targeting. The modified superoxide dismutase pH response type nano-liposome is obtained by modifying a superoxide dismutase nano-liposome with hyaluronic acid, and the modified superoxide dismutase pH response type nano-liposome has the advantages that the modified superoxide dismutase pH response type nano-liposome can be accurately targeted by the aid of the synergistic anti-photoaging after-sun repair composition; the superoxide dismutase nano-liposome is of a core-shell structure, a core layer is superoxide dismutase, a shell layer is a ternary composite liposome, and the ternary composite liposome is formed by compounding HSPC, DSPC and cholesterol. By constructing a pH response type nano delivery system, the pH drop characteristic of an ultraviolet damage area can be accurately recognized, controlled release of SOD at a target site is triggered, O2 <-> and H2O2 are synchronously removed, an oxidative stress chain reaction is blocked, and in cooperation with the inhibition of tetrahydrocurcumin on a tyrosinase signal channel and the anti-inflammatory repair effect of the aloe extract, the anti-inflammatory repair effect of the aloe extract on the tyrosinase signal channel is achieved. A three-dimensional action network of targeted removal-activity regeneration-barrier reconstruction is formed, and the photoaging prevention and treatment effect is improved.

The invention discloses a preparation method of a nano embedding material based on a low-temperature superfine grinding technology, and belongs to the technical field of modified nano materials. The method comprises the following steps: cleaning and slicing fresh beautiful millettia root and stem, performing programmed liquid nitrogen freezing, and performing jet milling to obtain nano powder; the preparation method comprises the following steps: taking anionic polysaccharide, neutral polysaccharide nanoparticles, nano-modified cassava starch and deionized water, magnetically stirring, carrying out ultrasonic treatment, and mixing for 30-45 minutes; mixing the wall material solution with the nano-powder, performing ultrasonic treatment to form a coating solution, adding calcium chloride and Tween 80, and stirring; and spraying a magnesium chloride solution at the voltage of 40-60kV and the flow rate of 0.5-1.5 mL / h, stirring, mixing with a chitosan solution according to the mass ratio of 1: (2-4), adjusting the pH value, stirring, and freeze-drying to obtain the product. The millettia specisoa champ embedding method retains the active ingredients of millettia specisoa champ, improves the embedding efficiency by 85-96%, is stable, controls release, and is suitable for health care products and drug carriers.

The invention belongs to the technical field of plant care essential oil extraction, and particularly relates to sanshool delayed care essential oil and a preparation method thereof. The invention discloses a sanshool-enriched lipid composition which is prepared from the following components in parts by weight: 0.05 to 0.1 part of sanshool-enriched fraction, 1 to 2 parts of solid lipid, 1 to 1.5 parts of liquid lipid, 1.5 to 2.5 parts of stable surfactant, 1 to 2 parts of cosurfactant, 3 to 5 parts of glycerol, 0.2 to 0.5 part of soothing anti-irritation component, 0.05 to 0.1 part of sodium hyaluronate, 0.1 to 0.3 part of hydroxypropyl methyl cellulose, 0.05 to 0.1 part of antioxidant and the balance of purified water. According to the invention, sanshool is used as a core functional factor, and through collaborative design of supercritical extraction, molecular distillation purification, NLC carrier encapsulation and a soothing film-forming system, contradictions of effectiveness, mildness and the like in an existing scheme are solved, and mild desensitization, stable controlled release, reduction of stimulation and migration risks and improvement of tolerance and action consistency are realized.

The invention relates to the technical field of laboratory safety monitoring, and discloses a laboratory hazardous gas leakage monitoring method and system, and the method comprises the steps: configuring an electronic identity tag for a hazardous gas related article, deploying a read-write device in an operation region, and automatically generating a temporary operation voucher with timeliness when the article enters the operation region; the environment concentration is monitored in real time through a gas sensor, and when abnormity is detected, whether a matching voucher exists or not is checked firstly so as to distinguish normal operation and abnormal leakage; according to the method, through a dynamic coupling mechanism of the operation certificate and the area sensing, controlled release and accidental leakage are distinguished, the balance problem of traditional threshold value alarm between sensitivity and false alarm rate is improved, and the reliability of the system is improved. And meanwhile, the accuracy of leakage detection and the robustness of the system are improved by combining near-field gradient verification and an air flow abrupt change self-adaptive strategy.

The invention provides a purification method of mesenchymal stem cell exosomes, prepared mesenchymal stem cell exosome particles and application of the mesenchymal stem cell exosome particles, and belongs to the technical field of exosomes. The preparation method comprises the following steps: performing multiplication culture on adipose-derived stem cells to stimulate exosome secretion, then performing gradient centrifugation, collecting supernate, adding a protective agent, uniformly stirring and mixing, adding a polymer, stirring and incubating, centrifuging, collecting exosome particles, washing, and freeze-drying to obtain the mesenchymal stem cell exosome particles. The mesenchymal stem cell exosome particle prepared by the invention is simple in preparation method, relatively low in cost, easy to realize industrial application and high in yield, meanwhile, the mesenchymal stem cell exosome particle has a very good protection effect on exosomes, the preservation period of the exosomes is prolonged, and the prepared mesenchymal stem cell exosome particle has the characteristic of releasing the exosomes in a sustained and controlled release manner and has a good application prospect. The traditional Chinese medicine composition is widely applied to preparation of anti-inflammatory, anti-oxidation and skin repair promoting medicines.

The invention belongs to the field of biomedical materials, and discloses a preparation method and application of a mesoporous polydopamine nano preparation loaded with ultra-small nano enzyme. The nano preparation takes mesoporous polydopamine nanoparticles as a carrier skeleton and is combined with ultra-small nano enzyme through an in-situ reaction: the mesoporous polydopamine nanoparticles can efficiently carry drugs and accurately deliver the drugs to inflammatory tissues such as psoriasis, gout, colitis and the like by virtue of a modified targeting ligand by virtue of high specific surface area, biocompatibility and modifiability; the ultra-small nano enzyme has catalytic activity of catalase and the like, and can remove active oxygen and relieve oxidative stress. The two components are combined to achieve a synergistic effect, so that the catalytic efficiency of the enzyme is improved by virtue of the characteristics of the carrier, the high activity of the enzyme under different conditions is maintained by virtue of the stability of the carrier, and the platform can synchronously realize targeted delivery, enzymatic treatment and drug controlled release, and has a wide application prospect in the fields of inflammatory disease intervention and wound repair. And an efficient, accurate and low-toxicity universal treatment strategy is provided for chronic inflammatory diseases.

The invention relates to a bionic nano CO generator as well as preparation and application thereof, belongs to the technical field of medicines, and solves the problem that a CO delivery system which can synergistically promote neuroprotection and neurogenesis and has brain targeting and controlled release capabilities is urgently required to be developed at present. According to the technical scheme, the bionic nano CO generator comprises a drug-loaded particle inner core and a covering film, the drug-loaded particle inner core comprises hollow mesoporous CeO2 nano particles and MnCO loaded on the hollow mesoporous CeO2 nano particles, and the covering film is a macrophage membrane and wraps the drug-loaded particle inner core. The compound is used for apoplexy treatment administration by integrating neuroprotection and enhancing innovative dual channels of endogenous nerve growth, and is expected to significantly reduce brain injury after cerebral apoplexy and restore neurological functions so as to relieve the worry about high death rate and long-term disability after cerebral ischemia-reperfusion injury.

The invention discloses a self-inflating underwater buoy cabin released through electromagnetic control. The self-inflating underwater buoy cabin is characterized in that a locking and disengaging device is arranged in a floating bag cabin shell; in an initial state, the buoy is folded and placed in the shell of the floating bag cabin; the lower end of the buoy is in locking connection with the locking-disengaging device. And during separation and release, after the electromagnetic valve unlocks the buoy by the locking and releasing device, the buoy is ejected upwards by the locking and releasing device, and the buoy is automatically inflated to further float and unfold by utilizing the reduction of external water pressure. Compressed gas in the pressure bottle is injected into the floating bag by utilizing the actual process that the external pressure is gradually reduced when the buoy floats upwards, so that automatic inflation is realized, the size of the buoy is further reduced by adopting the flexible antenna, and finally, the miniaturization design of the whole buoy is realized.

The invention discloses preparation of a GSH responsive photo-thermal chemical synergetic liquid metal nanocomposite and application of the GSH responsive photo-thermal chemical synergetic liquid metal nanocomposite in tumor treatment, and relates to the field of nano biomedical materials. According to the composite material, gallium-tin alloy (GaSn) is used as an inner core, a reduced graphene oxide (RGO) middle layer and a manganese dioxide (MnO2) outer shell are sequentially coated, a three-layer core-shell structure is formed, and the average particle size is controlled to be about 60 nm. The liquid metal composite nanomaterial has excellent photothermal conversion performance and oxidation resistance. The compound not only can be used for treating tumors and cancers, quickly killing cancer cells and effectively inhibiting tumor growth, but also can quickly deplete GSH, break dynamic balance of redox and improve ROS level in cells. Experiments show that the material shows a remarkable inhibition effect on tumor cells, has good biocompatibility and regulation and control release characteristics, and provides a new strategy for precise synergistic treatment of solid tumors.

The invention relates to the technical field of food packaging, in particular to a dual-antioxidant packaging film as well as a preparation method and application thereof. The dual antioxidant packaging film disclosed by the invention is prepared from the following components in parts by mass: 3.2 to 4 parts of starch, 0.8 to 1 part of glycerol, 0.8 to 1 part of polysaccharide, 0.02 to 0.16 part of berberine / anthocyanin self-assembled nanoparticles and 93.98 to 95.2 parts of water. The packaging film prepared by the invention is uniform in structure, has good mechanical properties and moisture and oxygen barrier properties, shows an intelligent slow release characteristic in a pH value change or oxidation environment, can realize controllable release of the tea tree essential oil, and significantly improves the antioxidant and antibacterial activity of the film. The material source is natural, renewable and biodegradable, and the environment-friendly fresh-keeping packaging material is suitable for fresh-keeping packaging of foods such as fruits, vegetables and meat products, and has good environment friendliness and industrial application prospects.

The present invention relates to the use of certain polyacrylamide gel formulations to treat conditions where cartilage has degraded and / or where exposed collagen is present. The invention further relates to the prophylactic use of such formulations to prevent degradation, or further degradation, of cartilage and / or collagen. Additionally, the invention also includes substituting such certain polyacrylamide gel formulations in lieu of carboxymethylcellulose, or alternatively HA, in individuals and mammals having allergies, sensitivities, or other adverse reactions to such compounds. Additionally, the invention further relates to the use of the polyacrylamide gel formulations for the controlled release of therapeutic agents and / or as a medical scaffold or matrix for biological therapies.

The utility model relates to a bone grafting instrument. The bone grafting instrument comprises a handle, an extension tube, a sealing cover and a storage bin for placing broken bones, the front end of the handle protrudes from back to front to form a protruding part, the extension pipe is communicated with the protruding part, and the sealing cover is in threaded connection with the end, away from the extension pipe, of the handle. According to the bone grafting instrument, through the mechanical structure of the pushing rod and the pushing plate, broken bones can be rapidly and effectively pushed to the position between adjacent vertebrae from the storage bin, the operation efficiency is greatly improved, the operation time and discomfort of a patient are reduced, the top plate and the closing assembly are used in cooperation, the broken bones can be accurately controlled to be released in the pushing process, and the bone grafting effect is improved. Compared with the prior art, excessive scattering or blocking of broken bones is avoided, the accuracy and the success rate of an operation are guaranteed, in addition, the storage bin is closed through the closing assembly, the broken bones are effectively prevented from leaking in the pushing process, the clean and sterile state of an operation area is kept, and the infection risk is reduced.

The invention relates to chitosan-based microcapsules for detecting, treating, or preventing fungal growth in enclosed environments. These microcapsules release at least one compound when triggered during fungal development. This selective release mechanism ensures efficient use of the compounds and minimizes waste. The invention also relates to a fungal growth detection kit for enclosed environments, the kit comprising the microcapsules and a detector configured to detect the compounds and emit a signal indicating the presence of fungal growth. Abstract figure: Figure 1

The invention provides a meat preservation method with self-assembled nanoparticles cooperating with a three-layer controlled release film. The method comprises the following steps: S1, selecting fresh meat, removing impurities, cleaning, detecting the muscle fiber density and the total number of initial bacterial colonies, classifying the meat into I / II / III classes according to the standard, and pre-cooling and discharging acid for 18-24 hours under the conditions that the temperature is 0-2 DEG C, the air speed is 0.3-0.5 m / s and the humidity is 85-90%; s2.2, graded loading of dormant-state self-assembled nanoparticles at the temperature of 2-4 DEG C, I-type dip coating, II-type ultrasonic-assisted dip coating, III-type high-pressure atomization spraying and air drying in a blast environment after loading; s3, filling three layers of controlled release films, vacuumizing to-0.095 to-0.09 MPa, keeping for 20 seconds, filling customized controlled atmosphere according to grades, and then performing heat sealing; and S4.0, refrigerating at 0-4 DEG C. By constructing a synergistic mechanism that the self-assembled nano-particle adsorption layer recognizes a decay signal in a close range and the three layers of controlled release films release drugs in a linkage mode and strengthen barrier, the limitation that traditional preservation is passively inhibited and active ingredients are lost quickly is broken through, and the technical problems that bacteriostasis is not lasting, the water-retaining property is poor and sensory quality is prone to deterioration are fundamentally solved; and the fresh-keeping efficiency and the meat quality are both improved.

The invention discloses a self-repairing bio-based coating material giving consideration to nutrient controlled release and membrane shell degradation and a preparation method of the self-repairing bio-based coating material, and belongs to the technical field of controlled release fertilizer production. The self-repairing bio-based coating material is prepared from the following raw materials in parts by weight: 80 to 100 parts of easily degradable polyester polyol, 30 to 50 parts of cross-linking promoting agent and 10 to 20 parts of functional chain extender. According to the self-repairing bio-based coating material and the preparation method thereof, the easily degradable polyester polyol reacts with the cross-linking promoting agent and the functional chain extender to synthesize the self-repairing bio-based coating material which gives consideration to nutrient controlled release and membrane shell degradation, and the self-repairing bio-based coating material can improve the toughness of a membrane material, promote rapid repairing of a damaged area and improve the service life of the membrane material. The stability of nutrient release is improved; in addition, a chain reaction of structural fracture can be triggered in the membrane material degradation process, and the degradation rate of a membrane shell after nutrients are completely released is increased. The invention effectively solves the problem that the degradation performance of the membrane shell and the controlled release performance of nutrients are difficult to coexist.

According to the continuous piston gas storage device with the flow control function, a supporting rod is installed at the upper end of an integrated diaphragm, the periphery of the supporting rod is connected to the top of a tank body in a sliding mode, a displacement sensor is arranged on the supporting rod or the integrated diaphragm, and the displacement sensor is used for detecting the relative position of the integrated diaphragm in the tank body; a lower cavity is arranged in the tank body and below the integrated membrane, an upper cavity is arranged in the tank body and above the integrated membrane, the lower cavity is filled with sample gas, and the upper cavity is filled with shielding gas. According to the continuous piston gas storage device with the flow control function, the upper cavity is arranged in the tank body and above the integrated membrane, the lower cavity is used for being filled with sample gas, the integrated membrane is arranged in the upper cavity in a sliding mode in the axial direction, and the tank body is used for sampling and gas storage. The pressure and the volume of the upper cavity can be maintained to control the gas storage pressure and the gas storage amount in the lower cavity, and the volume and the release pressure of released sample gas can be controlled by adjusting the volume and the pressure of the upper cavity.

The invention relates to the field of macromolecules, and discloses a polymer as well as a preparation method and application thereof. The polymer has a chemical structural unit as shown in a formula 1. Compared with polyester, the polymer disclosed by the invention has the characteristics of higher degradation rate in a water environment, large molecular weight and good heat resistance or mechanical property, and can be applied to the fields of degradable packaging materials, drug controlled release carriers and the like.

The invention provides a volatile oil adsorption carrier, and a preparation method and application thereof, the volatile oil adsorption carrier comprises the following components by mass: 60% of a hydrophobic core (based on the total amount of the carrier), and the hydrophobic core is composed of hydrophobic mesoporous silica and a Fe3O4 molecular plug. Wherein the hydrophobic mesoporous silica accounts for 54-59 parts, and the Fe3O4 molecular plug accounts for 1-6 parts. Wherein the specific surface area of hydrophobic mesoporous silica is greater than or equal to 800 m < 2 > / g, and the aperture is 5-10 nm The particle size of the Fe3O4 molecular plug is 5-8 nm, and the Fe3O4 molecular plug is embedded into the pore inlet of the hydrophobic mesoporous silica. And 40% of a cross-linked lipophilic shell. The volatile oil adsorption carrier provided by the invention has a biphasic core-shell structure with a hydrophobic core and a cross-linked lipophilic shell, and realizes partition adsorption, hole blocking and oil locking, and swelling resistance and controlled release.

The application discloses an upper critical solution temperature responsive mesoporous silicon and a preparation method and application thereof, and is characterized in that: mesoporous silicon is coated on the outside of copper sulfide nanoparticles (CuS NPs), and then the coated CuS NPs are subjected to amination by using an APTES solution, and then a temperature-sensitive material PEG-p(AAm-co-AN) is grafted to form the upper critical solution temperature responsive mesoporous silicon. The application has the advantages of simple method, easy operation and mild reaction condition; the final product has good stability, can be used for loading a chemotherapeutic drug doxorubicin hydrochloride, and can realize drug controlled release; has temperature response drug release performance, and the phase transition temperature of the carrier is 43 DEG C, which is suitable for the microenvironment of tumor tissues; can be subjected to photothermal therapy under the irradiation of a 980nm laser, and realizes the synergistic effect of photothermal therapy and chemotherapy.

The invention provides a lung tissue sustained and controlled release material loaded with BMP4 and GANT61 and a preparation method of the lung tissue sustained and controlled release material, and relates to the technical field of disease treatment and delivery materials. The invention relates to a preparation method of a lung tissue sustained and controlled release material loaded with BMP4 and GANT61. The preparation method comprises the following steps: synthesizing HPG by adopting an anionic ring-opening polymerization method; the preparation method comprises the following steps: mixing HPG with PLA, and reacting to prepare a copolymer PLA-HPG; the copolymer PLA-HPG and GANT61 are blended and subjected to a reaction, and nano particles loaded with GANT61 are prepared; and the GANT61-loaded nano particles and BMP4 are subjected to a mixed reaction, such that the BMP4 and GANT61-loaded lung tissue sustained and controlled release material is prepared. The invention constructs a lung tissue sustained and controlled release material loaded with BMP4 and GANT61, and verifies that the lung tissue sustained and controlled release material can realize an anti-pulmonary fibrosis treatment strategy by inducing alpha-SMA + myofibroblast transdifferentiation, resisting inflammation, resisting oxidation and other multiple targets.

The invention provides a silicon dioxide essence microcapsule which is characterized in that essence is coated in a hydrophobic organic compound in a mononuclear or multinuclear form to form a core layer; and silicon dioxide is a shell layer. The outer layer of the microcapsule is a silicon dioxide shell, the secondary outer layer is a hydrophobic organic compound which is solid at room temperature, and essence is dispersed in the secondary outer layer in a single-core or multi-core form. The preparation method adopts a soap-free method and comprises the following steps: mixing and emulsifying essence, an organic compound which is in a solid state at room temperature and a polyalkoxy siloxane precursor, and then performing hydrolytic condensation on the precursor on a water phase interface to form a silicon dioxide shell so as to realize coating. The method is environment-friendly, and a surfactant does not need to be added. The obtained microcapsule has the characteristics of high encapsulation efficiency, excellent long-acting slow release performance, excellent thermal response controlled release capability and capability of desorbing and reloading essence after being used, and has wide application prospects in the fields of daily chemicals, textiles, foods and the like.