847 results about "Controlled release" patented technology

The invention discloses a pure bio-based PHA aqueous dispersion as well as a preparation method and application thereof, and belongs to the technical field of pure bio-based polymer aqueous dispersion. According to the dispersion, polyhydroxyalkanoate is used as a unique film forming matter, Pickering solid particles and a natural surfactant are adopted for synergistic stabilization, and a bio-based plasticizer can be selected. The emulsion or slurry with the polyhydroxyalkanoate content of 40-85wt% and the particle size of 0.2-3m is prepared through a melting high-pressure homogenization method, a low-temperature wet grinding method or a solvent replacement method. The coating does not contain petrochemical polymer protective colloid and perfluorinated and polyfluoroalkyl substances, and the bio-based content is greater than or equal to 99%. Due to the excellent stability, rheological property and film-forming property of the modified starch, the modified starch becomes an ideal basic material for constructing a multi-layer programmable controlled release and degradation functional coating system, can be used in the fields of paper-based barrier coatings, adhesives, advanced crop seed coats and the like, realizes excellent barrier, bonding and controlled release properties, meets the industrial compost and repulping property standards, and has wide application prospects. The method has green, environment-friendly and industrial potential.

The invention discloses a multi-layer controllable degradation coating composition as well as a preparation method and application thereof, and belongs to the field of biodegradable high polymer materials and coating compositions. The coating composition comprises an outer protective layer and an inner functional layer, and the inner functional layer is arranged between a substrate and the outer protective layer and comprises a plurality of microcapsules. The key innovation lies in that the microcapsule encapsulates an enzyme capable of catalytically degrading the outer protective layer and is configured to be released after a predetermined delay time. The pH buffer system is integrated in the inner functional layer, and an optimal catalytic microenvironment is created for released enzyme, so that the outer protective layer is actively and quickly degraded, and programmable time-controlled removal is realized. The problem that the degradation rate of an existing biodegradable material is passive and uncontrollable is solved, and the coating has a remarkable application value in the field of seed coating or fertilizer controlled release by endowing the coating with a unique two-stage degradation characteristic.

The invention relates to the technical field of metal surface protection, and discloses a corrosion-resistant self-repairing metal fastener and a preparation method thereof.The corrosion-resistant self-repairing metal fastener comprises a zinc alloy matrix, a nanometer passivation layer, a slow-release corrosion-resistant layer and a self-repairing functional layer, and the nanometer passivation layer, the slow-release corrosion-resistant layer and the self-repairing functional layer sequentially wrap the zinc alloy matrix; the zinc alloy matrix consists of Al, Cu, Mg, Ce and Zn; the nano passivation layer adopts zinc phosphate / silane composite sol to construct a Si-O-P covalent bond network, and plasma is combined to graft epoxy groups to enhance the interface bonding strength; the slow-release anti-corrosion layer is used for loading a pH response type benzotriazole derivative through gradient aperture mesoporous silica, so that the dynamic controlled release of a corrosion inhibitor is realized; the self-repairing functional layer adopts a synergistic effect of a mechanical triggering type sulfydryl siloxane microcapsule and a pH triggering type EDTA chelating agent microcapsule to form a physical plugging-chemical passivation dual-mode repairing mechanism. Through four-stage cooperation of matrix modification, interface strengthening, slow-release regulation and control and intelligent repair, the corrosion resistance of the corrosion-resistant self-repairing metal fastener in a complex environment is remarkably enhanced.

The invention relates to the technical field of biological medicine, in particular to a wound repair material and a preparation method and application thereof.The wound repair material is in a gel shape and comprises hydrogel and platelet-rich plasma, the hydrogel is formed by dynamic crosslinking of collagen and oxidized hyaluronic acid, and the hydrogel physically encapsulates the platelet-rich plasma. The gelatinous wound repair material provides bionic mechanical support through a dynamic cross-linked network, synergistically regulates and controls an inflammation microenvironment and sequential release of PRP growth factors, remarkably promotes angiogenesis and wound healing, is suitable for the clinical treatment fields of diabetic ulcer, chronic difficult-to-heal wounds and the like, and has broad application prospects. The material has the functions of mechanical support, anti-inflammatory regulation and growth factor controlled release.

The invention discloses a composite microbial enzyme preparation and a preparation method thereof, and belongs to the technical field of bioplastic degradation. The enzyme preparation is synergistically constructed through a temperature-sensitive MOFs / Schiff base network composite carrier and black phosphorus quantum dots, FeO (at) ZIF-8 is taken as a core, and PNIPAM is grafted on the surface to form temperature-responsive MOFs; constructing a three-dimensional network carrier through Schiff base crosslinking of the CMC and the CNF; the complex enzyme is loaded on MOFs pore channels and then is embedded in a carrier network together with the black phosphorus quantum dots. The temperature-sensitive MOFs open pore channels to release enzyme when the compost is heated, and the Schiff base network dissociates secondary released enzyme under an acidic condition; the black phosphorus quantum dots promote enzyme activity and strengthen carrier response through a photothermal effect; the compound enzyme contains cutinase, alkaline lipase, neutral lipase, alpha-amylase, saccharifying enzyme, cellulase, laccase and protease, and can synergistically degrade PLA, PBAT and starch-based plastic. According to the invention, dual environment response controlled release, photo-thermal synergistic catalysis and synergistic degradation of the enzyme preparation are realized, and the plastic degradation period is shortened under the composting condition.

Provided is a delivery system for an artificial implant, comprising a control handle (400) and a catheter assembly (200) connected proximally to the control handle. The catheter assembly (200) comprises an outer sheath (240) and an inner shaft assembly located within the outer sheath (240), the artificial implant (100) being connected to the distal end of the inner shaft assembly and controlled by the control handle (400). The control handle (400) comprises a first handle (41) and a second handle (42) operatively cooperating with each other, the first handle (41) being configured to drive axial movement of the outer sheath (240) to achieve deployment and folding of the artificial implant, and the second handle (42) being configured to control release of the artificial implant to achieve detachment of the artificial implant from the delivery system.

The invention belongs to the technical field of genetic engineering and biological medicine, and particularly discloses a cascade response type nano-particle with a microenvironment remodeling function and a preparation method and application of the cascade response type nano-particle. The nanoparticle provided by the invention adopts a bionic hybrid membrane engineering strategy: an inner core is formed by loading an exosome inhibitor on a nano material, and the surface is covalently coupled with M2 type macrophage specific targeting peptide; the outer layer coats a macrophage membrane and active oxygen response type liposome composite membrane layer through a co-extrusion technology, and is loaded with a TLR agonist. Animal experiments show that after being injected through caudal vein, the nano-particles are enriched at a tumor site in a targeted manner through homing receptors such as membrane surface integrin alpha4beta1 and the like, and outer membrane cracking is triggered in a high-ROS tumor microenvironment, so that space-time controlled release of a TLR agonist and targeted phagocytosis of an exosome inhibitor by macrophages guided by a targeted peptide are realized. The anti-tumor synergistic effect is achieved through multiple regulation and control mechanisms, and an effective treatment strategy is provided for tumor immunotherapy.

A multi-pore aroma diffuser device includes an accommodation base and a porous diffuser to be detachably assembled on the accommodation base to replace existing diffuser stones. Through the porous material structure and a liquid storage bottle inside the device, fragrance liquid is continuously provided for the porous diffuser to continuously emit fragrance, and there is no need to rely on electricity or energy-consuming heating to produce fragrance. It has a long service life and slowly and controlled release of fragrance. The porous diffuser is detachably assembled on the accommodation base. The detachable design allows for easy replacement of the liquid storage bottle. It also greatly simplifies the weight and complexity of the overall structure, making it easy to use and conducive to releasing the effectiveness of the fragrance.

The invention discloses a perfluorohexanone fire extinguishing agent fire extinguishing method and system applied to a power switch cabinet fire, and belongs to the technical field of power system energy storage equipment.The method comprises the steps that an arc light signal is detected through an arc light detection device, and a partial discharge signal is detected through an ultrasonic partial discharge detection device; meanwhile, temperature data and smoke concentration data in the cabinet are detected through a temperature and smoke detection device; signal fusion is executed, and a comprehensive fire hazard grade judgment value is generated; comparing the comprehensive fire hazard grade judgment value with a preset fire hazard grade threshold value, and judging the fire hazard grade; and the release mechanism is controlled to release the perfluorohexanone fire extinguishing agent. According to the invention, through multi-signal fusion and a physical power model, the fire stage is dynamically discriminated, the dosage of the perfluorohexanone is adaptively controlled, the fire extinguishing accuracy and efficiency are improved, the false alarm rate is reduced, and data recording and intelligent management are supported.

The invention belongs to the technical field of biological medicine, and particularly relates to a manganese-doped zeolite imidazole framework and application thereof in tumor radiotherapy. According to the present invention, the new use of the manganese-doped zeolite imidazole framework as the tumor radiosensitizer is found, Mn-ZIF-8 has ray responsiveness, can continuously release Mn < 2 + > ions under X-ray irradiation, and can enhance the activation of a cGAS-STING signal channel so as to promote DCs maturation and antigen presentation, and enhance the T cell mediated immune response, such that the tumor treatment effect is enhanced. Furthermore, the invention provides the Mn-ZIF-8 microneedle, the microneedle has the characteristics of rapid dissolution and controlled release, ensures accurate delivery and continuous action of drugs at tumor sites, reduces systemic toxicity, and can significantly amplify local and systemic immune effects caused by radiotherapy and improve the therapeutic effect when used in combination with an immune checkpoint inhibitor.

The invention discloses a bone repair material based on pH controlled release and a preparation method thereof. The bone repair material comprises the following raw materials: polycaprolactone, nano hydroxyapatite and nano magnesium oxide. The composite bone repair scaffold has the beneficial effects that the composite bone repair scaffold with excellent biocompatibility, excellent osteogenesis performance, excellent degradation performance and pH controlled release of magnesium ions is prepared by printing the bone repair material through a 3D printing technology, a temporary three-dimensional structure can be provided for cells, cell adhesion, proliferation and differentiation are promoted, growth factors are released at the same time, and the growth rate of the cells is increased. The formation of new bone tissues is guided; the composite bone repair scaffold can continuously and quantitatively release magnesium ions through pH value control, when osteoarthritis or bone tissue inflammation occurs at a bone defect part due to improper operation and rejection reaction, the magnesium ion release speed of the composite bone repair scaffold is increased, the anti-inflammatory effect is achieved, and the magnesium ions which are continuously released can promote bone tissue repair.

The invention discloses a rod core, a punching type implant as well as a preparation method and application of the punching type implant. The rod core comprises a drug-containing layer, and the drug-containing layer comprises active drugs and auxiliary materials. The auxiliary materials comprise sustained and controlled release auxiliary materials; the molecular weight of the sustained and controlled release auxiliary material is 10000-10000 thousands; the medicine-adjuvant ratio is 1: (0.01-100); the medicine-adjuvant ratio represents the mass ratio of the active medicine to the adjuvant in the medicine-containing layer; optionally, the rod core of the punching type implant also comprises a boosting layer compounded on the medicine-containing layer. The implant provided by the invention can be suitable for most drugs, and can realize long-acting release of the drugs.

Disclose is a separator for separating liquid from a fluid stream including a mixture of gas and liquid. The separator comprises a first vessel including an outlet and an inlet for receiving the fluid stream, the first vessel in fluid communication with a second vessel via a first valve, the second vessel in fluid communication with a liquid outlet via a second valve, wherein the first vessel is arranged to enable the liquid to flow into the second vessel. The separator also has a second valve for controlling release of liquid from the second vessel, the first and second valves being pneumatically operated, the pneumatic operation of the first and second valves allowing only one of the first and second valves to be open during operation of the separator.

The invention relates to the technical field of agricultural fertilizer preparation, and discloses a preparation method of a water-soluble fertilizer rich in various active amino acids, which comprises the following steps: S1, preparing an amino acid solution: dissolving various free amino acids or polypeptides in a buffer solution to form an amino acid precursor liquid; s2, constructing a nutrition core layer: adding one or more types of soluble trace element salts and a gelation auxiliary agent into the amino acid precursor liquid to form gelatinous particles; s3, forming an intermediate response layer: coating the core particles with chitosan and phospholipid to form a bimolecular membrane structure. The stability of the particle structure is improved through low-temperature crosslinking and bi-component gelation, and quick response and continuous controlled release in a weak acid environment are realized by combining an intermediate response membrane and an outer controlled release shell layer; by adopting a structure-function integrated design, the suspension property and the dispersity are remarkably improved, and the multi-crop and multi-period precise fertilization requirements are met.

The invention discloses an antibiotic slow-release system based on hierarchical porous silicon dioxide and a preparation method of the antibiotic slow-release system, and belongs to the technical field of biological medicines. The antibiotic slow-release system comprises a spherical hierarchical-pore silicon dioxide microsphere carrier, amino functional groups covalently bonded to the outer surface and the inner surface of a pore channel of the spherical hierarchical-pore silicon dioxide microsphere carrier, antibiotic molecules loaded in the pore channel of the spherical hierarchical-pore silicon dioxide microsphere carrier, and a pH-responsive chitosan gating layer. The preparation method comprises the following steps: (1) preparing a hierarchical pore silicon dioxide microsphere carrier; (2) aminating the surface of the carrier; (3) loading antibiotics; and (4) constructing the pH responsive chitosan gating layer. According to the invention, the silicon dioxide carrier with a macroporous-mesoporous hierarchical structure is constructed to realize high drug loading capacity, and the pH-responsive chitosan gating layer is covalently bonded at the orifice of the silicon dioxide carrier to realize intelligent controlled release, so that the problem that high drug loading capacity, low burst release rate and biological safety are difficult to achieve at the same time in the prior art is solved.

The invention relates to the technical field of scale inhibition materials, in particular to a slowly-dissolved micro-nano dispersion scale inhibition material and a preparation method thereof. The composite material comprises a four-layer structure, wherein a porous hydroxyapatite core anchors DTPMP through phosphate radical vacancy to inhibit burst release; sulfonated polyetheretherketone and a cross-linking agent are compounded to form an ion selective controlled release layer, and the diffusion rate of the scale inhibitor is regulated and controlled; photo-thermal conversion graphene quantum dots are embedded in a temperature-sensitive hydrogel shell, and dynamic release is triggered through temperature or Ca < 2 + > concentration; and the corrosion resistance and the mechanical stability are enhanced by the atomic layer deposited ceramic layer and the epoxy resin packaging layer. By constructing a four-layer composite slow-release system, long-acting scale inhibition, extreme tolerance and dynamic response are achieved, the technical problems that a traditional scale inhibition material is high in burst release rate, poor in weather resistance and delayed in release are solved, the water treatment cost per ton is low, the RO membrane service life is long, and a full-period efficient scale inhibition solution is provided for a complex industrial water system.

The invention discloses an oral instant film suitable for pet nutrition intervention and a preparation method of the oral instant film, and belongs to the technical field of pet oral preparations. The instant film adopts a sandwich type multi-layer structural design, sequentially comprises a first food calling layer, a core layer and a second food calling layer, can be selectively provided with a functional layer and an interface middle layer, and constructs a staggered hot-pressing laminated structure, so that the structural stability and the function delivery efficiency of a film body are remarkably improved. The core layer contains multiple composite active ingredients such as L-carnitine, coenzyme Q10, beta-glucan, glucosamine sulfate and the like, chitosan-inulin-polyglutamic acid or starch is adopted for embedding to form a first microcapsule and a second microcapsule, and intelligent delivery of temperature / pH response and gastrointestinal controlled release is achieved. The food calling layer is composed of chicken powder, fish oil powder, fructo-oligosaccharide and the like, and the feeding compliance of pets is improved.

The invention relates to the field of wound dressings and the field of flexible strain sensors, in particular to an intelligent wound dressing with drug controlled release and motion detection functions and a preparation method of the intelligent wound dressing. The wound dressing comprises thermoplastic polyurethane, liquid metal, lauric acid and curcumin, a TPU elastic material serves as a substrate, the liquid metal serves as a photo-thermal agent and a sensor flexible circuit part, the motion monitoring function can be achieved, and good biocompatibility is achieved; lauric acid is used as a thermal phase change material, curcumin is used as a bioactive drug, and photo-thermal response drug controlled release is achieved; the intelligent wound dressing with photo-thermal drug controlled release and motion monitoring functions is prepared by combining electrostatic spinning, electrostatic spraying and template printing technologies, and has a wide application prospect in the field of wound dressings.

The invention belongs to the technical field of fire extinguishing agents, and particularly relates to a lithium battery microcapsule fire extinguishing coating and a preparation method and application thereof. By means of the microcapsule technology, the heat stability and the response speed of the fire extinguishing agent are improved. And through the core-shell structure design, effective coating and controlled release of the fire extinguishing agent are achieved. The hydroxymethyl cellulose is used as a matrix, so that the adhesive force and the mechanical strength of the coating are enhanced, a uniform fireproof layer is further formed on the surface of the lithium battery, and the thermal safety performance of the battery is improved. Therefore, the microcapsule fire extinguishing coating for the lithium battery disclosed by the invention can quickly release the microcapsule fire extinguishing agent when the battery is subjected to thermal runaway, so as to realize an inhibition effect on thermal runaway propagation.

The present invention relates to the technical field of diabetes, and in particular to a controlled-release diabetic wound healing promoting treatment method, comprising the following treatment experimental steps: step S1: preparation of Hst1@PNPs; step S2: Coomassie brilliant blue staining; step S3: scanning and transmission electron microscopy detection; in the present invention, a slow-release Hst1 treatment method is constructed by encapsulating Hst1 into platelet membrane vesicles derived from autologous blood. On the one hand, the PNPs encapsulate the linear Hst1 peptide structure to prevent it from being rapidly degraded by high proteases in diabetic wound exudate, thereby improving bioavailability. On the other hand, the PNPs can adsorb excess LPS in the wound exudate, and cooperate with Hst1 to achieve anti-inflammatory and anti-oxidative stress effects. Subsequent cell and animal experiments further confirmed that Hst1@PNPs have the effects of anti-inflammatory, scavenging ROS, promoting re-epithelialization, collagen deposition and angiogenesis, thereby promoting diabetic wound healing.

The invention discloses a PVA / urea / CC lignocellulose composite mulching film as well as a preparation method and application thereof, and belongs to the technical field of agricultural mulching films. The composite mulching film disclosed by the invention is obtained by adding PVA (Polyvinyl Alcohol) into a corncob lignocellulose HTP-CC dispersion liquid subjected to hydrothermal pretreatment, then sequentially adding glutaraldehyde, urea and glycerol and carrying out cross-linking reaction. The mechanical property of the PUCH mulching film prepared by the invention meets the GB / T35795-2017 standard, and the PUCH mulching film has excellent water vapor barrier property, ultraviolet shielding property, urea controlled release property, heat insulation property and biodegradability. The characteristics not only can promote crop growth, but also can reduce agricultural environmental pollution. Therefore, the PUCH mulching film shows huge potential to replace the traditional plastic mulching film, and has important application prospects in agricultural planting.

The invention discloses a composite curcumin nano pesticide and a preparation method and application thereof.The nano pesticide comprises a carrier and curcumin loaded on the carrier, the carrier is polydopamine-sodium lignin sulfonate, and the polydopamine-sodium lignin sulfonate is formed by polymerizing dopamine hydrochloride on the surface of lignin; the preparation method comprises the following steps: preparing a curcumin solution, adding the polydopamine-sodium lignin sulfonate powder, fully dispersing, slowly stirring under a dark condition until a yellow solution becomes dark red, and removing a solvent to obtain the polydopamine-sodium lignin sulfonate-curcumin. The nano pesticide provided by the invention takes polydopamine-sodium lignin sulfonate as a carrier, so that the drug has pH and photo-thermal response controlled release function, burst release of curcumin is avoided, and the stability and bioavailability of curcumin are improved.

The invention discloses a selenium-containing soluble composite microneedle as well as a preparation method and application thereof, and belongs to the technical field of biological materials and biological medicines, a microneedle forming matrix is selenized hyaluronic acid and medicine-loaded tetrahedral framework nucleic acid, and a substrate part is polyvinyl alcohol; the preparation method comprises the following steps: step 1, preparation of selenized hyaluronic acid; step 2, preparation of tetrahedral framework nucleic acid and drug loading; and step 3, preparation of the selenium-containing and drug-loaded microneedle patch. The selenized hyaluronic acid is synthesized through a specific chemical method, the selenized hyaluronic acid is used as a substrate to load the medicine-carrying tetrahedral framework nucleic acid, and the advantages of high permeability, good biocompatibility, editability and the like of the tetrahedral framework nucleic acid are utilized, so that the sustained and controlled release capacity of the microneedle is improved, efficient transdermal delivery of the medicine is realized, and the application prospect is broad. And pain and discomfort possibly caused by a traditional administration mode are reduced. The invention provides a novel and effective drug delivery system in the field of psoriasis treatment.

The invention belongs to the technical field of compressed air control, and particularly relates to a compressed air energy storage power station multistage protection and controlled discharge control method and system. Comprising the steps that a compressed air energy storage power station system comprising a discharge bypass and a discharge valve and a safety valve which are arranged on the downstream of the discharge bypass is built; when pressure abnormity occurs, first-stage response is started, operation parameters of the compressed air energy storage power station system are adjusted, or a discharge bypass is started in an overlapped mode, and the pressure abnormity trend is restrained; when the first-stage response cannot restrain pressure abnormity, the second-stage response is started, the opening degree of the release valve is adjusted, and gas release is conducted; and when the second-level response cannot restrain pressure abnormity, third-level response is started, a stepped release sequence is adopted, the opening degree of a release valve is increased, meanwhile, the opening degree of a safety valve is gradually increased to conduct gas release, and finally final release is conducted by triggering a rupture disk. According to the invention, through a stepped control strategy, the defects that a single protection device is single in protection means and easy to over-excite protection are avoided.

The invention belongs to the technical field of medical gel, and particularly relates to modified hydrogel for skin wound healing and a preparation method thereof.The modified hydrogel is prepared from, by weight, 2-5 parts of drug-loaded GDVLNs, 1-2 parts of chitosan, 0.6-1.5 parts of antioxidant, 0.2 part of LAP, 1.5 parts of MA, 18 parts of gel matrix and 100 parts of buffer solution, the drug-loaded GDVLNs prepared from the traditional Chinese medicine active ingredients and the ginseng vesicles have the functions of resisting oxidative stress, promoting angiogenesis, promoting cell proliferation and the like, and the MA modified hydrogel system can realize slow release and controlled release of the drug-loaded GDVLNs and play a long-acting healing promoting role.

The invention relates to the technical field of controlled-release microcapsules, and particularly discloses a pH-responsive mold-targeted controlled-release essence microcapsule for daily chemicals and a preparation method thereof.The preparation method comprises the following steps that S1, chitosan is dissolved with an acid solution, a catalyst and a pH sensitive reagent are added under the protective atmosphere for a reaction, and a pH-responsive graft copolymerization product is obtained through separation and purification; s2, mixing the pH response graft copolymerization product, a cross-linking agent and a mould targeting reagent for reaction, and dialyzing and purifying to obtain a microcapsule wall material; and S3, emulsifying essence by using an emulsifier, and then adding a defoaming agent, the microcapsule wall material, the sodium tripolyphosphate aqueous solution and a pH regulator to prepare the pH-responsive mold-targeted controlled-release essence microcapsule for daily use. The microcapsule integrates specific recognition targeting ability and pH response release ability to mould, and can accurately release natural essence with bacteriostatic and aromatic functions at the mould breeding part of clothes, so that the dual effects of bacteriostasis and aroma retention are realized.

The invention discloses a preparation method of immunoglobulin composite liposome nanoparticles with a controlled release characteristic, and belongs to the field of food nutrition and functional factors. Cholesterol and sitosterol are creatively used as auxiliary supports of a lecithin liposome skeleton, the stability of an immunoglobulin liposome nanoparticle structure is improved, the slow release property in the simulation effect process is improved, and a pH response type hydrogel film formed based on electrostatic crosslinking is prepared from calcium alginate and chitosan. A more stable double-layer shell-core structure is formed, so that the stability of embedded immune globulin molecules in gastric juice is further improved, and fixed-point slow release in small intestines is realized.

The invention discloses a sodium alginate / chitosan microsphere for loading cells and a preparation method, the preparation method comprises the following steps: adding a pore-foaming agent into a sodium alginate solution, and stirring overnight to obtain a sodium alginate solution containing the pore-foaming agent; the preparation method comprises the following steps: dissolving chitosan in an acetic acid solution, adding calcium chloride, and stirring until the calcium chloride is completely dissolved to obtain a chitosan mixed solution; dropwise adding a sodium alginate solution containing a pore-foaming agent into the chitosan mixed solution, standing, and filtering to obtain a microsphere precipitate; soaking the microsphere precipitate in a hydrochloric acid solution until no bubble overflows, filtering, cleaning and drying; according to the sodium alginate / chitosan microspheres for loading the cells, natural polymer materials, namely the sodium alginate and the chitosan, are adopted, so that excellent biocompatibility is ensured, and the rejection reaction risk is reduced; through a calcium carbonate pore-forming technology, the microspheres have an accurate pore structure, so that loading of cells and stable release of drugs are facilitated, the release rate is controlled, and the treatment effect is improved.

The invention provides low-viscosity high-wear-resistance vehicle engine oil and a preparation method thereof, and belongs to the technical field of engine oil. According to the preparation method, an ionic liquid group is introduced through a reaction, a nano interlayer compound is constructed by combining surface modification of a metal-ionic liquid complex and silicon dioxide nanoparticles, and a microcapsule structure is formed through coating of a urea-formaldehyde prepolymer; the ionic liquid group provides a low friction coefficient and thermal stability, the silicon dioxide nanoparticles provide physical isolation and wear-resistant protection, and the microcapsules realize controlled release and dynamic repair of the lubricating components; a skeleton polymer is prepared through a reaction of polyamidoamine and epoxy chloropropane so as to provide abundant active sites, and oxidation resistance is improved through a synergistic effect of the skeleton polymer, hindered phenol and calixarene; by combining oleic acid modified nanoparticles, the dispersity and the wear resistance are enhanced, and meanwhile, dynamic protection is provided on a friction interface; the synergistic effect prolongs the service life of the engine oil and improves the high-temperature stability of the engine oil.

The invention discloses a preparation method of a metagen microcapsule. The metagen microcapsule is prepared from a wall material and a core material through electrostatic spinning, the core material comprises a metagen compound coating at least two layers of chitosan-casein / pectin compound nanoparticles; the wall material comprises polyvinyl alcohol and polycyclohexane; the mass ratio of the metagen compound to the polyvinyl alcohol to the polycycloethane is (4-7.5): (0-3): (0-7). The three materials of chitosan, casein and pectin have excellent affinity with human tissues and cells, the survival rate of probiotics can be remarkably increased, and accurate controlled release of active substances is achieved. By optimizing a coating process and adopting an electrostatic spinning technology, the probiotics coated with chitosan, casein and pectin nanoparticles are prepared into the probiotic composite fiber, so that the storage capacity and the release efficiency of the probiotics are effectively improved, and meanwhile, the stability and the consistency of the product quality are ensured.