394results about "Osmotic delivery" patented technology

Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers, optionally in combination with growth hormone, to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of KATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are methods of co-administering KATP channel openers with other drugs (e.g., in combination with growth hormone) to treat diseases of humans and animals (e.g., Prader-Willi Syndrome (PWS), Smith-Magenis syndrome (SMS), and the like.

A drug injection device includes a drug injector configured to suck a drug from a drug storage by electrochemically operating an electroosmotic pump and discharge an sucked drug to an injection target; and a controller configured to output, to the drug injector, a control signal corresponding to an amount-based injection sequence for causing the electroosmotic pump to operate in an immediate bolus injection mode, wherein the amount-based injection sequence includes at least one pulse block defining a voltage pulse or a current pulse to be applied to the electroosmotic pump, the at least one pulse block defines a pair of pulse signals including a forward pulse and a reverse pulse that are applied to the electroosmotic pump to alternately generate negative pressure and positive pressure, and the electroosmotic pump alternately generates negative pressure and positive pressure for each pulse block to suck and discharge the drug.

An embodiment relates to an active implantable medical device (AIMD), comprising: a permeability module that allows ingress flow of a fluid to an osmotic agent chamber and generates osmotic pressure; a piston that moves longitudinally within the active implantable medical device (AIMD) in response to the osmotic pressure; a drug chamber that comprises a drug and a valve module to allow one-way flow of the drug from the drug chamber to outside the active implantable medical device (AIMD); a sensor module that measures a displacement of the piston in real-time; and an electronic module that communicates a signal to the valve module to control the valve module and regulate the one-way flow of the drug based on the displacement of the piston.

The invention provides a pharmaceutical composition, a rod core, an implant and a preparation method and application thereof. The pharmaceutical composition comprises the following components in parts by weight: 1-1000 parts of active pharmaceutical ingredients; 100 parts of R-vinyl silicone rubber; hydrogen-containing silicone oil; 0.000002 to 1 part of a catalyst; r in the R-vinyl silicone rubber is substituted or unsubstituted C1-C5 straight-chain alkane or branched alkane, and substituted or unsubstituted C6-C20 aromatic hydrocarbon; the content of vinyl in the R-vinyl silicone rubber is 0.10 to 0.50 mol%; the content of Si-H groups in the hydrogen-containing silicone oil is 0.15 to 1.6 mol percent; the molar ratio of Si-H group in the hydrogen-containing silicone oil to vinyl in the R-vinyl silicone rubber is (0.5-20): 1. The implant provided by the invention can reduce drug loss and sudden release phenomenon, the drug release is more stable, and the production speed is greatly increased.

A sustained administration device includes: a main body portion including an inner cavity; a plug that is slidable in a liquid-tight manner in the inner cavity; a pressing portion disposed on an upstream side of the plug in the inner cavity and presses the plug toward a downstream side; a substance to be administered that is accommodated on the downstream side of the plug in the inner cavity and is released into a living body by sliding of the plug toward the downstream side; and a release portion that is disposed on a distal end side of the main body portion and releases the substance to be administered pushed by the plug into the living body. The sustained administration device comprises a notification unit configured to perform a notification operation for notifying abnormality to the outside when an internal pressure of the inner cavity exceeds a predetermined threshold value.

The invention discloses a conical asymmetric nano robot for deep tumor penetration as well as a preparation method and application of the conical asymmetric nano robot. The structure of the asymmetric nano robot is Fe3O4 (at) mPDA (at) MnO2amp; mSiO2, and is marked as FPMamp; s; an FPMamp (Fabry Perot Module); the S nano-robot is nano-particles of an asymmetric structure, one end of the asymmetric structure is of a core-shell structure, the core is spherical Fe3O4, and the shell is mesoporous polydopamine particles; one end of the rod-like structure, which is far away from the Fe3O4, is conical; mnO2 is loaded on the surface of the mesoporous polydopamine; the asymmetric structure with the conical tail part is constructed, so that the forward wedging capability of the nano-robot in the moving process is improved, and the deep tumor penetrating performance is fundamentally improved; through the same nanorobot, collaborative treatment of multiple mechanisms of photo-thermal-Fenton-GSH depletion in space and time is achieved, the overall treatment efficiency of a deep tumor area is improved, and the problems that an existing asymmetric micro / nanorobot is insufficient in deep tumor penetrating capacity, the collaborative efficiency of a treatment module is limited and the like are solved.

The invention discloses a device with a function of relieving pain after hepatobiliary surgery, which comprises a waistband body, two ends of the waistband body are movably sleeved with an adjusting frame, two end faces of the adjusting frame are respectively provided with massage grooves, the front side surface of the adjusting frame is fixedly provided with a massage assembly, and the rear side surface of the adjusting frame is pasted with a disposable auxiliary assembly. A cold compress mesh belt is arranged at the position, between the two adjusting frames, of the waistband body, and a cold compress assembly is fixedly installed on the surface of the cold compress mesh belt; the device can be used for cold compress, massage and traditional Chinese medicine hot compress on the surgical site at the same time, pain and swelling are relieved at the same time, blood circulation is promoted, muscular tension is relieved, and the comfort of a patient is improved.

The present invention provides for the immediate or chronic administration of certain potassium ATP (K ATP ) channel openers, optionally in combination with growth hormone, to subjects to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic, and compositional outcomes in the treatment of diseases or conditions involving K ATP channels. Also provided are pharmaceutical formulations, methods of administration, and methods of dosing K ATP channel openers to achieve these outcomes and to reduce the incidence of adverse effects in treated individuals. Also provided are methods of co-administering K ATP channel openers with other drugs, e.g., in combination with growth hormone, to treat diseases in humans and animals, e.g., Prader-Willi Syndrome (PWS), Smith-Magenis Syndrome (SMS), etc.

The invention discloses a self-heating ginger-separated moxibustion patch which is mainly composed of a skin-friendly cloth applying layer, an iron powder heating layer, a traditional Chinese medicine combination layer, a ginger-separated synergistic layer and a release paper layer, and the skin-friendly cloth applying layer, the iron powder heating layer, the traditional Chinese medicine combination layer, the ginger-separated synergistic layer and the release paper layer are sequentially arranged from top to bottom. The iron powder heating layer is located in the middle of the skin-friendly compress layer, the traditional Chinese medicine combination layer is located on the surface of the iron powder heating layer, and the ginger separation synergistic layer is located in the middle of the traditional Chinese medicine combination layer. According to the self-heating moxibustion patch, the defect that the efficacy of an existing self-heating moxibustion patch is insufficient due to low temperature is overcome, and the user body feeling of the self-heating moxibustion patch is improved; according to the self-heating moxibustion patch, the defect that the effect of ginger moxibustion cannot be fully exerted in a component adding mode in an existing moxibustion patch is overcome, and traditional Chinese medicine components in the self-heating moxibustion patch can be better exerted.

The invention discloses a heating essential oil moxibustion paste and a preparation method thereof. The heating essential oil moxibustion paste comprises the following raw materials in parts by weight: 3-5% of composite effect essential oil, 5-10% of folium artemisiae argyi powder, 8-15% of a heating component, 1-2.5% of a fat-soluble emulsifier and the balance of natural base oil. Various essential oil formulas and heating components are combined to prepare the moxibustion cream which is convenient to carry and use, free of residual byproducts and integrated with essential oil permeation and moxibustion functions, and the moxibustion cream has the effects of warming and stimulating acupuncture points and relieving various sub-health states.

The invention discloses a pharmaceutical composition for treating diabetic foot ulcer in the technical field of medicine, the pharmaceutical composition comprises loropetalum chinense extract, angelica sinensis extract, liquorice extract, angelica dahurica extract and lithospermum erythrorhizon extract, and the application dosage form of the pharmaceutical composition is gel. A hydrogel carrier of the gel is antibacterial hydrogel which is formed by PDLA-CPC-PDLA and PLLA-PEG-PLLA through complexation, and the antibacterial hydrogel is adhered to an application capable of being heated by self; the antibacterial hydrogel is fixed on the surface of a wound through the application, the medicine is separated out from the hydrogel by utilizing the temperature difference between a patient and the application, and the medicine is accumulated on the surface of the wound, so that the absorption of the medicine by the wound is facilitated, and the healing process of the wound is accelerated.

The invention provides an external traditional Chinese medicine preparation for lymphedema, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from astragalus membranaceus, cassia twig, poria cocos, akebiaquinata, ligusticum wallichii, salvia miltiorrhiza, radix bupleuri, scutellaria baicalensis, lalang grass rhizome and herba lycopi, and all the medicines are combined to jointly achieve the effects of tonifying qi, activating blood, inducing diuresis, soothing liver-qi stagnation and clearing away heat and toxic materials. The traditional Chinese medicine preparation has obvious edema eliminating and anti-inflammatory effects on lymphedema model mice, and the treatment effect is remarkable. Meanwhile, the traditional Chinese medicine preparation for external treatment of lymphedema in traditional Chinese medicine provided by the invention can remarkably improve clinical symptoms of a patient, relieve pain of the patient, help the patient recover a functional state, reduce the level of inflammatory factors, promote edema absorption of the patient and remarkably relieve the lymphedema condition of an affected limb, and the curative effect is remarkable.

The invention discloses an intelligent temperature control health care patch and a preparation method thereof, and belongs to the technical field of medical instruments. The health care patch comprises a surface layer (a CO2 laser drilling PET film and a fluorosilane coating), a temperature control layer (paraffin / mesoporous silica composite phase change material), a medicine layer (wormwood essential oil-paraffin / sodium alginate microcapsules) and a bonding layer (silicone adhesive / hydrogenated castor oil). Ventilation and sweat prevention are achieved through the laser micropores and the hydrophobic coating, the phase change material composite system provides + / -1.4 DEG C temperature control precision, and the 48-hour medicine volatilization loss rate is only 3.2%. The preparation method adopts vacuum impregnation, low-temperature crosslinking and gradient curing processes, and interlayer bubble-free combination and efficient production are realized. The product has thermal therapy accuracy, medicine long-acting slow release property and skin adaptability, and is suitable for the field of chronic pain and joint nursing.

A chitosan-heparin nanomotor and a method for producing same are disclosed. A STING agonist-encapsulated urease-based chitosan-heparin nanomotor delivers the STING agonist directly to bladder mucosal cells in the bladder, and thus can induce an immune response.

Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers, optionally in combination with growth hormone, to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of KATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are methods of co-administering KATP channel openers with other drugs (e.g., in combination with growth hormone) to treat diseases of humans and animals (e.g., Prader-Willi Syndrome (PWS), Smith-Magenis syndrome (SMS), and the like.

Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice. The disclosed oral dosage forms provide once-a-day dosing of apremilast and are suitable for treating diseases or disorders ameliorated by inhibiting phosphodiesterase subtype IV (PDE4).

The present disclosure relates generally to methods of treating central nervous system disorders using (1R, 5S)-1-(naphthalen-2-yl)-3-azabicyclo [3.1. 0] hexane (i.e., sentanfardine) or a pharmaceutically acceptable salt thereof. More particularly, the present disclosure relates to the treatment of conditions affected by monoamine neurotransmitters.

The present application relates to a kind of traditional Chinese medicine composition for regulating irregular menstruation, traditional Chinese medicine powder bag and ironing heating bag.The traditional Chinese medicine composition includes the following weight parts components: 7-11 parts of raw rehmannia, 7-11 parts of Guangyujin, 1-5 parts of licorice, 7-11 parts of medlar, 4-8 parts of dried tangerine or orange peel, 7-11 parts of kudzu root, 7-11 parts of white atractylodes, 1-5 parts of sanqi.The ironing heating bag includes traditional Chinese medicine powder bag, heating layer and support, and the traditional Chinese medicine powder bag, heating layer and support are sequentially bonded to form sandwich structure;The ironing heating bag is attached to the user's abdominal segment of belt pulse.Compared with prior art, the traditional Chinese medicine composition and ironing heating bag of the present application act on human body belt pulse, have the effects of warming meridian and dispelling cold, promoting blood circulation to remove blood stasis, regulating belt pulse, and have significant curative effect on irregular menstrual cycle, less menstrual flow, blood stasis, dysmenorrhea, amenorrhea and other symptoms.

The invention includes an orally ingestible delivery system for releasing a therapeutic agent within an intestine of a mammal, where the system includes the therapeutic agent and a differentially permeable capsule system containing the therapeutic agent within a therapeutic agent compartment, with the differentially permeable capsule system dimensionally adapted for oral ingestion and for passage into a stomach of the mammal and thence into the intestine, wherein the differentially permeable capsule system comprises an acid-resistant shell and a dispersible acid barrier, wherein the dispersible acid barrier forms while the orally-ingestible delivery system is in the stomach; and wherein the dispersible acid barrier is dispersed in the intestine, thereby permitting enzymes in the intestine to reach the therapeutic agent compartment. The invention also includes methods of manufacturing the system and methods for its use.

The present application relates to a polymer and a composition thereof, and specifically provides a thermosensitive polymer represented by formula (I-2) and a preparation method therefor, and a pharmaceutical composition containing same, the polymer having a star-shaped multi-arm structure, and comprising an aromatic core and a biodegradable AB-type amphiphilic copolymer. The polymer can enhance the solubility and stability of a drug or a bioactive agent and control the release of the drug or the bioactive agent. The definition of each group in formula (I-2) is the same as in the description.

A delayed timed release pharmaceutical composition, a preparation method therefor, and use thereof. The pharmaceutical composition comprises a tablet core. The tablet core comprises a drug-containing layer and a boosting layer stacked on the drug-containing layer. The drug-containing layer comprises a drug active ingredient. The drug active ingredient is levodopa or a derivative thereof, or a mixture of levodopa or a derivative thereof and a DOPA decarboxylase inhibitor, and accounts for 5-72.5 wt% of the content of the drug-containing layer. The pharmaceutical composition is a capsule-shaped tablet, can realize the effects of 1-3 h delayed release of the drug active ingredient and reaching a peak concentration at 6-10 h, can be used for reducing morning stiffness in patients with Parkinson's disease, and has good application prospects.

The present invention provides a traditional Chinese medicine composition, a preparation method thereof and an application, belonging to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition of the present invention comprises raw materials in the following parts by weight: 3-5 parts of Atractylodes lancea, 3-5 parts of Gentiana macrophylla, 7-9 parts of Ligusticum chuanxiong, 10-14 parts of Carthamus tinctorius, 3-5 parts of Notopterygium incisum, 10-14 parts of Angelica sinensis, 10-14 parts of Cyathula officinalis, 3-5 parts of Cyperus rotundus, and 7-9 parts of Glycyrrhiza uralensis. Based on the situation of stasis in patients with arthralgia syndrome, the present invention performs drug compatibility for those with stasis in arthralgia syndrome, and has a significant therapeutic effect on arthralgia syndrome caused by wind, cold, dampness and stasis.

The present invention can provide: a colon purgation tablet having a gel-forming coating layer containing an alginate as a main component, the gel-forming coating layer being introduced into an uncoated tablet containing an osmotic substance, the present invention relates to an uncoated tablet, and more particularly, to an uncoated tablet, such that the osmotic substance contained in the uncoated tablet disintegrates rapidly while preventing damage to gastric mucosa due to a physical collision between the tablet and the gastric mucosa, and thus provides an excellent intestinal cleansing effect. The colon purgation tablet according to the present invention can exhibit an excellent intestinal cleansing effect even at a small dose, and can further improve drug compliance by selectively miniaturizing the tablet or introducing an adhesive to improve a coating layer.

A method and apparatus for the targeted delivery of chemotherapy to a surgical cavity, consisting of a triggered nanoparticle encapsulating a therapeutic agent and an energy delivery device that applied trigger energy to the surgical cavity. Following surgical removal of a cancerous tumor, the nanoparticle is administered, and the energy delivery device applies trigger energy to the surgical cavity and proximal tissue. The goal is the delivery of a therapeutic drug dose to cancerous and precancerous cells remaining after surgery, to prevent local tumor recurrence.

This invention discloses a substitute smoke for seawater vegetables and its application device, relating to the technical field of substitute smoke for seawater vegetables. To improve ease of use, the device includes a grip base. Two connecting frames are fixed to the outer bottom wall of the grip base by screws. The inner walls of the two connecting frames are rotatably connected to the same wheel via a central shaft. A rubber ring is provided between the outer circumference of the central shaft and the inner wall of the connecting frames. The wheel is integrally provided with evenly distributed circumferentially distributed movable receiving tubes. The substitute smoke for seawater vegetables, by weight, comprises: 30-50 parts of Suaeda salsa, 15-25 parts of Artemisia argyi, and 5-10 parts of Lonicera japonica. This invention, through the design of the grip base and wheel, allows for the storage of multiple moxibustion sticks using the wheel, facilitating replacement. Furthermore, when the moxibustion stick is pushed into the fixed receiving tube, it acts as a pin, limiting the wheel's movement and preventing rotation, thus improving practicality.

The invention discloses a teenager myopia rehabilitation moxibustion physiotherapy composition and a preparation method thereof, and belongs to the technical field of moxibustion physiotherapy. The juvenile myopia rehabilitation moxibustion physiotherapy composition comprises the following raw materials in parts by weight: 208.4 parts of wormwood, 4 parts of ligusticum chuanxiong hort, 4 parts of divaricate saposhnikovia root, 4 parts of medlar, 4 parts of astragalus membranaceus, 4 parts of rose, 4 parts of ginseng, 3.2 parts of mint, 3.2 parts of angelica sinensis, 3.2 parts of semen cassiae, 3.2 parts of schizonepeta, 3.2 parts of rhizoma polygonati, 3.2 parts of gardenia, 2 parts of dendrobe, 2 parts of mulberry, 2 parts of coptis chinensis, 2 parts of salvia miltiorrhiza, 2 parts of lavender, 1.4 parts of rhizoma alismatis, 1.4 parts of celery, 1.4 parts of ixeris sonchifolia hance, 1.4 parts of spina gleditsiae and 1.4 parts of salix leaves. And 1.4 parts of tripterygium wilfordii. The teenager myopia rehabilitation moxibustion physiotherapy has obvious effects in the aspects of rehabilitation of visual transmission nerves and brain recognition nerves, and the vision can be recovered to 0.8 or above generally within one month.

The invention provides a volatile oil adsorption carrier, and a preparation method and application thereof, the volatile oil adsorption carrier comprises the following components by mass: 60% of a hydrophobic core (based on the total amount of the carrier), and the hydrophobic core is composed of hydrophobic mesoporous silica and a Fe3O4 molecular plug. Wherein the hydrophobic mesoporous silica accounts for 54-59 parts, and the Fe3O4 molecular plug accounts for 1-6 parts. Wherein the specific surface area of hydrophobic mesoporous silica is greater than or equal to 800 m < 2 > / g, and the aperture is 5-10 nm The particle size of the Fe3O4 molecular plug is 5-8 nm, and the Fe3O4 molecular plug is embedded into the pore inlet of the hydrophobic mesoporous silica. And 40% of a cross-linked lipophilic shell. The volatile oil adsorption carrier provided by the invention has a biphasic core-shell structure with a hydrophobic core and a cross-linked lipophilic shell, and realizes partition adsorption, hole blocking and oil locking, and swelling resistance and controlled release.

The invention discloses a moxa stick containing traditional Chinese medicine components for treating infertility and a preparation method of the moxa stick, relates to the technical field of traditional Chinese medicine instruments, and mainly solves the technical problem of low skin permeation efficiency of the medicine components in the moxibustion process. According to the technical scheme, the preparation method comprises the following steps: preparing traditional Chinese medicine powder consisting of angelica sinensis, prepared rehmannia root, semen cuscutae, fructus lycii, ligusticum wallichii, rhizoma cyperi, salvia miltiorrhiza and borneol according to specific parts by mass, and controlling the average particle size to be 10-50 microns; the moxa and the traditional Chinese medicine powder are mixed according to the mass ratio of (3-5): 1 to form a medicine core layer; the periphery of the medicine core layer is wrapped with a pure moxa heat conduction layer with the thickness of 2-4 mm; and finally, wrapping the periphery of the heat conduction layer with a mulberry paper barrier layer with the thickness of 0.1-0.3 mm. Through the combined action of the three-layer structure, the medicine release and heat conduction path is optimized, the medicine transdermal efficiency is remarkably improved, and the high-efficiency traditional Chinese medicine moxa stick for treating infertility is prepared.

The invention relates to the field of biological medicine, in particular to a preparation method and application of a compound preparation, and the compound preparation is prepared from the following raw materials in parts by mass: 10-15 parts of fructus evodiae, 10-15 parts of fructus psoraleae, 5-10 parts of semen cuscutae, 10-15 parts of fennel, 5-10 parts of fructus amomi, 10-15 parts of rhizoma cyperi, 10-15 parts of perillaseed, 10-15 parts of frankincense and 10-15 parts of myrrh. The fructus evodiae is used for dispelling cold coagulation and relieving arthralgia, the fructus psoraleae is used for strengthening the spleen, the semen cuscutae is used for tonifying the kidney, the fennel and the fructus amomi are used for strengthening the transportation and transformation functions of the spleen and the stomach, the rhizoma cyperi and the perillaseed are used for soothing the liver and regulating qi, and the frankincense and the myrrh are added for promoting qi circulation The hot compress bag, the acupoint patch and the massage essential oil prepared by the invention are mainly used for treating muscular pain, eliminating cold to stop pain, warming and activating meridians and tonifying liver and kidney, are used for treating the temporomandibular joint disorder, have the effect of treating both symptoms and root causes, and enhance the long-term effect of treating the temporomandibular joint disorder. Wide application prospects are realized.