524results about "Osmotic delivery" patented technology

The invention discloses a dependency-free anti-aging sleep-aiding preparation and a preparation method thereof, and relates to the technical field of preparations, the anti-aging sleep-aiding preparation comprises an ellipsoidal shell and an ellipsoidal core wrapped in the ellipsoidal shell, the ellipsoidal core comprises an anti-aging agent layer, a water absorption expansion layer and a sleep-aiding agent layer which are stacked in sequence, the water absorption expansion layer protrudes at the two ends of the ellipsoidal core to form small water diversion columns; small water inlet holes are formed in the two ends of the ellipsoidal shell and are connected with small water diversion columns; a plurality of first release holes and a plurality of second release holes are formed in the circumferential surface of the ellipsoidal shell, the plurality of first release holes lead to the anti-aging agent layer, and the plurality of second release holes lead to the sleep aid layer. Through the special structural design of the ellipsoidal shell and the ellipsoidal core, isolated coexistence of anti-aging and sleep-aiding components and controllable release of the anti-aging and sleep-aiding components are achieved, so that the dual effects of anti-aging and sleep-aiding can be achieved, and it is guaranteed that the drug effect is continuously exerted.

The invention relates to particular substituted deuterated heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and / or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving 5-HT2A receptor, serotonin transporter (SERT) and / or pathways involving dopamine D1 / D2 receptor signaling systems, and / or the treatment of residual symptoms.

Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers, optionally in combination with growth hormone, to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of KATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are methods of co-administering KATP channel openers with other drugs (e.g., in combination with growth hormone) to treat diseases of humans and animals (e.g., Prader-Willi Syndrome (PWS), Smith-Magenis syndrome (SMS), and the like.

Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers, optionally in combination with growth hormone, to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of KATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are methods of co-administering KATP channel openers with other drugs (e.g., in combination with growth hormone) to treat diseases of humans and animals (e.g., Prader-Willi Syndrome (PWS), Smith-Magenis syndrome (SMS), and the like.

A drug injection device includes a drug injector configured to suck a drug from a drug storage by electrochemically operating an electroosmotic pump and discharge an sucked drug to an injection target; and a controller configured to output, to the drug injector, a control signal corresponding to an amount-based injection sequence for causing the electroosmotic pump to operate in an immediate bolus injection mode, wherein the amount-based injection sequence includes at least one pulse block defining a voltage pulse or a current pulse to be applied to the electroosmotic pump, the at least one pulse block defines a pair of pulse signals including a forward pulse and a reverse pulse that are applied to the electroosmotic pump to alternately generate negative pressure and positive pressure, and the electroosmotic pump alternately generates negative pressure and positive pressure for each pulse block to suck and discharge the drug.

An embodiment relates to an active implantable medical device (AIMD), comprising: a permeability module that allows ingress flow of a fluid to an osmotic agent chamber and generates osmotic pressure; a piston that moves longitudinally within the active implantable medical device (AIMD) in response to the osmotic pressure; a drug chamber that comprises a drug and a valve module to allow one-way flow of the drug from the drug chamber to outside the active implantable medical device (AIMD); a sensor module that measures a displacement of the piston in real-time; and an electronic module that communicates a signal to the valve module to control the valve module and regulate the one-way flow of the drug based on the displacement of the piston.

The invention provides a pharmaceutical composition, a rod core, an implant and a preparation method and application thereof. The pharmaceutical composition comprises the following components in parts by weight: 1-1000 parts of active pharmaceutical ingredients; 100 parts of R-vinyl silicone rubber; hydrogen-containing silicone oil; 0.000002 to 1 part of a catalyst; r in the R-vinyl silicone rubber is substituted or unsubstituted C1-C5 straight-chain alkane or branched alkane, and substituted or unsubstituted C6-C20 aromatic hydrocarbon; the content of vinyl in the R-vinyl silicone rubber is 0.10 to 0.50 mol%; the content of Si-H groups in the hydrogen-containing silicone oil is 0.15 to 1.6 mol percent; the molar ratio of Si-H group in the hydrogen-containing silicone oil to vinyl in the R-vinyl silicone rubber is (0.5-20): 1. The implant provided by the invention can reduce drug loss and sudden release phenomenon, the drug release is more stable, and the production speed is greatly increased.

A sustained administration device includes: a main body portion including an inner cavity; a plug that is slidable in a liquid-tight manner in the inner cavity; a pressing portion disposed on an upstream side of the plug in the inner cavity and presses the plug toward a downstream side; a substance to be administered that is accommodated on the downstream side of the plug in the inner cavity and is released into a living body by sliding of the plug toward the downstream side; and a release portion that is disposed on a distal end side of the main body portion and releases the substance to be administered pushed by the plug into the living body. The sustained administration device comprises a notification unit configured to perform a notification operation for notifying abnormality to the outside when an internal pressure of the inner cavity exceeds a predetermined threshold value.

The invention discloses a conical asymmetric nano robot for deep tumor penetration as well as a preparation method and application of the conical asymmetric nano robot. The structure of the asymmetric nano robot is Fe3O4 (at) mPDA (at) MnO2amp; mSiO2, and is marked as FPMamp; s; an FPMamp (Fabry Perot Module); the S nano-robot is nano-particles of an asymmetric structure, one end of the asymmetric structure is of a core-shell structure, the core is spherical Fe3O4, and the shell is mesoporous polydopamine particles; one end of the rod-like structure, which is far away from the Fe3O4, is conical; mnO2 is loaded on the surface of the mesoporous polydopamine; the asymmetric structure with the conical tail part is constructed, so that the forward wedging capability of the nano-robot in the moving process is improved, and the deep tumor penetrating performance is fundamentally improved; through the same nanorobot, collaborative treatment of multiple mechanisms of photo-thermal-Fenton-GSH depletion in space and time is achieved, the overall treatment efficiency of a deep tumor area is improved, and the problems that an existing asymmetric micro / nanorobot is insufficient in deep tumor penetrating capacity, the collaborative efficiency of a treatment module is limited and the like are solved.

The invention discloses a device with a function of relieving pain after hepatobiliary surgery, which comprises a waistband body, two ends of the waistband body are movably sleeved with an adjusting frame, two end faces of the adjusting frame are respectively provided with massage grooves, the front side surface of the adjusting frame is fixedly provided with a massage assembly, and the rear side surface of the adjusting frame is pasted with a disposable auxiliary assembly. A cold compress mesh belt is arranged at the position, between the two adjusting frames, of the waistband body, and a cold compress assembly is fixedly installed on the surface of the cold compress mesh belt; the device can be used for cold compress, massage and traditional Chinese medicine hot compress on the surgical site at the same time, pain and swelling are relieved at the same time, blood circulation is promoted, muscular tension is relieved, and the comfort of a patient is improved.

The present invention provides for the immediate or chronic administration of certain potassium ATP (K ATP ) channel openers, optionally in combination with growth hormone, to subjects to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic, and compositional outcomes in the treatment of diseases or conditions involving K ATP channels. Also provided are pharmaceutical formulations, methods of administration, and methods of dosing K ATP channel openers to achieve these outcomes and to reduce the incidence of adverse effects in treated individuals. Also provided are methods of co-administering K ATP channel openers with other drugs, e.g., in combination with growth hormone, to treat diseases in humans and animals, e.g., Prader-Willi Syndrome (PWS), Smith-Magenis Syndrome (SMS), etc.

The invention discloses a self-heating ginger-separated moxibustion patch which is mainly composed of a skin-friendly cloth applying layer, an iron powder heating layer, a traditional Chinese medicine combination layer, a ginger-separated synergistic layer and a release paper layer, and the skin-friendly cloth applying layer, the iron powder heating layer, the traditional Chinese medicine combination layer, the ginger-separated synergistic layer and the release paper layer are sequentially arranged from top to bottom. The iron powder heating layer is located in the middle of the skin-friendly compress layer, the traditional Chinese medicine combination layer is located on the surface of the iron powder heating layer, and the ginger separation synergistic layer is located in the middle of the traditional Chinese medicine combination layer. According to the self-heating moxibustion patch, the defect that the efficacy of an existing self-heating moxibustion patch is insufficient due to low temperature is overcome, and the user body feeling of the self-heating moxibustion patch is improved; according to the self-heating moxibustion patch, the defect that the effect of ginger moxibustion cannot be fully exerted in a component adding mode in an existing moxibustion patch is overcome, and traditional Chinese medicine components in the self-heating moxibustion patch can be better exerted.

The invention discloses a heating essential oil moxibustion paste and a preparation method thereof. The heating essential oil moxibustion paste comprises the following raw materials in parts by weight: 3-5% of composite effect essential oil, 5-10% of folium artemisiae argyi powder, 8-15% of a heating component, 1-2.5% of a fat-soluble emulsifier and the balance of natural base oil. Various essential oil formulas and heating components are combined to prepare the moxibustion cream which is convenient to carry and use, free of residual byproducts and integrated with essential oil permeation and moxibustion functions, and the moxibustion cream has the effects of warming and stimulating acupuncture points and relieving various sub-health states.

The invention discloses a pharmaceutical composition for treating diabetic foot ulcer in the technical field of medicine, the pharmaceutical composition comprises loropetalum chinense extract, angelica sinensis extract, liquorice extract, angelica dahurica extract and lithospermum erythrorhizon extract, and the application dosage form of the pharmaceutical composition is gel. A hydrogel carrier of the gel is antibacterial hydrogel which is formed by PDLA-CPC-PDLA and PLLA-PEG-PLLA through complexation, and the antibacterial hydrogel is adhered to an application capable of being heated by self; the antibacterial hydrogel is fixed on the surface of a wound through the application, the medicine is separated out from the hydrogel by utilizing the temperature difference between a patient and the application, and the medicine is accumulated on the surface of the wound, so that the absorption of the medicine by the wound is facilitated, and the healing process of the wound is accelerated.

The invention provides an external traditional Chinese medicine preparation for lymphedema, and relates to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from astragalus membranaceus, cassia twig, poria cocos, akebiaquinata, ligusticum wallichii, salvia miltiorrhiza, radix bupleuri, scutellaria baicalensis, lalang grass rhizome and herba lycopi, and all the medicines are combined to jointly achieve the effects of tonifying qi, activating blood, inducing diuresis, soothing liver-qi stagnation and clearing away heat and toxic materials. The traditional Chinese medicine preparation has obvious edema eliminating and anti-inflammatory effects on lymphedema model mice, and the treatment effect is remarkable. Meanwhile, the traditional Chinese medicine preparation for external treatment of lymphedema in traditional Chinese medicine provided by the invention can remarkably improve clinical symptoms of a patient, relieve pain of the patient, help the patient recover a functional state, reduce the level of inflammatory factors, promote edema absorption of the patient and remarkably relieve the lymphedema condition of an affected limb, and the curative effect is remarkable.

The invention discloses an intelligent temperature control health care patch and a preparation method thereof, and belongs to the technical field of medical instruments. The health care patch comprises a surface layer (a CO2 laser drilling PET film and a fluorosilane coating), a temperature control layer (paraffin / mesoporous silica composite phase change material), a medicine layer (wormwood essential oil-paraffin / sodium alginate microcapsules) and a bonding layer (silicone adhesive / hydrogenated castor oil). Ventilation and sweat prevention are achieved through the laser micropores and the hydrophobic coating, the phase change material composite system provides + / -1.4 DEG C temperature control precision, and the 48-hour medicine volatilization loss rate is only 3.2%. The preparation method adopts vacuum impregnation, low-temperature crosslinking and gradient curing processes, and interlayer bubble-free combination and efficient production are realized. The product has thermal therapy accuracy, medicine long-acting slow release property and skin adaptability, and is suitable for the field of chronic pain and joint nursing.

A chitosan-heparin nanomotor and a method for producing same are disclosed. A STING agonist-encapsulated urease-based chitosan-heparin nanomotor delivers the STING agonist directly to bladder mucosal cells in the bladder, and thus can induce an immune response.

Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers, optionally in combination with growth hormone, to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of KATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are methods of co-administering KATP channel openers with other drugs (e.g., in combination with growth hormone) to treat diseases of humans and animals (e.g., Prader-Willi Syndrome (PWS), Smith-Magenis syndrome (SMS), and the like.

The invention discloses application of a cannabidiol analogue CIAC001 in preparation of a medicine for treating Alzheimer's disease, and relates to the technical field of medicine. The application comprises the following steps: step 1, medicine extraction: extracting CIAC001, an NMDA receptor antagonist and a cholinesterase inhibitor according to a ratio of 1: 5: 5 into a medicine carrying needle cylinder; 2, medicine heating, wherein a heating assembly is started to conduct pulse heating on the medicine in the medicine carrying needle cylinder; 3, nursing the patient: heating and nursing the injection part of the patient by using a nursing assembly; 4, medicine injection: pushing a pushing head, puncturing a needle into the injection part of the patient, and injecting the medicine into the body of the patient; and 5, observing and treating side reactions: taking down the injection device after the drug reaction is complete, observing the side reaction condition of the patient, and starting a temperature regulator to cool the patient. The medicine activity can be effectively improved, side effects of the medicine on patients are reduced, and therefore the treatment effect of the medicine is enhanced.

Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice. The disclosed oral dosage forms provide once-a-day dosing of apremilast and are suitable for treating diseases or disorders ameliorated by inhibiting phosphodiesterase subtype IV (PDE4).

The present disclosure relates generally to methods of treating central nervous system disorders using (1R, 5S)-1-(naphthalen-2-yl)-3-azabicyclo [3.1. 0] hexane (i.e., sentanfardine) or a pharmaceutically acceptable salt thereof. More particularly, the present disclosure relates to the treatment of conditions affected by monoamine neurotransmitters.

The present application relates to a kind of traditional Chinese medicine composition for regulating irregular menstruation, traditional Chinese medicine powder bag and ironing heating bag.The traditional Chinese medicine composition includes the following weight parts components: 7-11 parts of raw rehmannia, 7-11 parts of Guangyujin, 1-5 parts of licorice, 7-11 parts of medlar, 4-8 parts of dried tangerine or orange peel, 7-11 parts of kudzu root, 7-11 parts of white atractylodes, 1-5 parts of sanqi.The ironing heating bag includes traditional Chinese medicine powder bag, heating layer and support, and the traditional Chinese medicine powder bag, heating layer and support are sequentially bonded to form sandwich structure;The ironing heating bag is attached to the user's abdominal segment of belt pulse.Compared with prior art, the traditional Chinese medicine composition and ironing heating bag of the present application act on human body belt pulse, have the effects of warming meridian and dispelling cold, promoting blood circulation to remove blood stasis, regulating belt pulse, and have significant curative effect on irregular menstrual cycle, less menstrual flow, blood stasis, dysmenorrhea, amenorrhea and other symptoms.

The invention includes an orally ingestible delivery system for releasing a therapeutic agent within an intestine of a mammal, where the system includes the therapeutic agent and a differentially permeable capsule system containing the therapeutic agent within a therapeutic agent compartment, with the differentially permeable capsule system dimensionally adapted for oral ingestion and for passage into a stomach of the mammal and thence into the intestine, wherein the differentially permeable capsule system comprises an acid-resistant shell and a dispersible acid barrier, wherein the dispersible acid barrier forms while the orally-ingestible delivery system is in the stomach; and wherein the dispersible acid barrier is dispersed in the intestine, thereby permitting enzymes in the intestine to reach the therapeutic agent compartment. The invention also includes methods of manufacturing the system and methods for its use.

The present application relates to a polymer and a composition thereof, and specifically provides a thermosensitive polymer represented by formula (I-2) and a preparation method therefor, and a pharmaceutical composition containing same, the polymer having a star-shaped multi-arm structure, and comprising an aromatic core and a biodegradable AB-type amphiphilic copolymer. The polymer can enhance the solubility and stability of a drug or a bioactive agent and control the release of the drug or the bioactive agent. The definition of each group in formula (I-2) is the same as in the description.

A delayed timed release pharmaceutical composition, a preparation method therefor, and use thereof. The pharmaceutical composition comprises a tablet core. The tablet core comprises a drug-containing layer and a boosting layer stacked on the drug-containing layer. The drug-containing layer comprises a drug active ingredient. The drug active ingredient is levodopa or a derivative thereof, or a mixture of levodopa or a derivative thereof and a DOPA decarboxylase inhibitor, and accounts for 5-72.5 wt% of the content of the drug-containing layer. The pharmaceutical composition is a capsule-shaped tablet, can realize the effects of 1-3 h delayed release of the drug active ingredient and reaching a peak concentration at 6-10 h, can be used for reducing morning stiffness in patients with Parkinson's disease, and has good application prospects.

The present invention provides a traditional Chinese medicine composition, a preparation method thereof and an application, belonging to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition of the present invention comprises raw materials in the following parts by weight: 3-5 parts of Atractylodes lancea, 3-5 parts of Gentiana macrophylla, 7-9 parts of Ligusticum chuanxiong, 10-14 parts of Carthamus tinctorius, 3-5 parts of Notopterygium incisum, 10-14 parts of Angelica sinensis, 10-14 parts of Cyathula officinalis, 3-5 parts of Cyperus rotundus, and 7-9 parts of Glycyrrhiza uralensis. Based on the situation of stasis in patients with arthralgia syndrome, the present invention performs drug compatibility for those with stasis in arthralgia syndrome, and has a significant therapeutic effect on arthralgia syndrome caused by wind, cold, dampness and stasis.

The present invention can provide: a colon purgation tablet having a gel-forming coating layer containing an alginate as a main component, the gel-forming coating layer being introduced into an uncoated tablet containing an osmotic substance, the present invention relates to an uncoated tablet, and more particularly, to an uncoated tablet, such that the osmotic substance contained in the uncoated tablet disintegrates rapidly while preventing damage to gastric mucosa due to a physical collision between the tablet and the gastric mucosa, and thus provides an excellent intestinal cleansing effect. The colon purgation tablet according to the present invention can exhibit an excellent intestinal cleansing effect even at a small dose, and can further improve drug compliance by selectively miniaturizing the tablet or introducing an adhesive to improve a coating layer.

A method and apparatus for the targeted delivery of chemotherapy to a surgical cavity, consisting of a triggered nanoparticle encapsulating a therapeutic agent and an energy delivery device that applied trigger energy to the surgical cavity. Following surgical removal of a cancerous tumor, the nanoparticle is administered, and the energy delivery device applies trigger energy to the surgical cavity and proximal tissue. The goal is the delivery of a therapeutic drug dose to cancerous and precancerous cells remaining after surgery, to prevent local tumor recurrence.

The invention discloses a herbal folium artemisiae argyi production process which comprises the following steps: taking fresh folium artemisiae argyi, rhizoma acori graminei, mint and radix angelicae, soaking, rinsing, blanching with boiled water added with salt, soaking in cold water for 1 hour, drying after soaking, and controlling the moisture to be below 5%; s2, adding the folium artemisiae argyi, rhizoma acori graminei, mint and radix angelicae ingredients dried in the step S1 and the high-viscosity attapulgite clay powder into a high-speed crushing roller, adding a negative ion formula at the same time, and crushing into a powdery mixture with the particle fineness being less than or equal to 0.085 mm. The jade, the zeolite, the tourmaline, the ferric oxide and the elm powder are added, infrared rays can be emitted and negative ions can be released during combustion, the negative ions can promote synthesis and storage of vitamins in the human body, physiological activities of the human body can be strengthened and activated, the moxa stick can be fully combusted, and the smoke abatement effect is achieved.