249results about "Osmotic delivery" patented technology

An embodiment relates to an active implantable medical device (AIMD), comprising: a permeability module that allows ingress flow of a fluid to an osmotic agent chamber and generates osmotic pressure; a piston that moves longitudinally within the active implantable medical device (AIMD) in response to the osmotic pressure; a drug chamber that comprises a drug and a valve module to allow one-way flow of the drug from the drug chamber to outside the active implantable medical device (AIMD); a sensor module that measures a displacement of the piston in real-time; and an electronic module that communicates a signal to the valve module to control the valve module and regulate the one-way flow of the drug based on the displacement of the piston.

The invention discloses a conical asymmetric nano robot for deep tumor penetration as well as a preparation method and application of the conical asymmetric nano robot. The structure of the asymmetric nano robot is Fe3O4 (at) mPDA (at) MnO2amp; mSiO2, and is marked as FPMamp; s; an FPMamp (Fabry Perot Module); the S nano-robot is nano-particles of an asymmetric structure, one end of the asymmetric structure is of a core-shell structure, the core is spherical Fe3O4, and the shell is mesoporous polydopamine particles; one end of the rod-like structure, which is far away from the Fe3O4, is conical; mnO2 is loaded on the surface of the mesoporous polydopamine; the asymmetric structure with the conical tail part is constructed, so that the forward wedging capability of the nano-robot in the moving process is improved, and the deep tumor penetrating performance is fundamentally improved; through the same nanorobot, collaborative treatment of multiple mechanisms of photo-thermal-Fenton-GSH depletion in space and time is achieved, the overall treatment efficiency of a deep tumor area is improved, and the problems that an existing asymmetric micro / nanorobot is insufficient in deep tumor penetrating capacity, the collaborative efficiency of a treatment module is limited and the like are solved.

The present invention provides for the immediate or chronic administration of certain potassium ATP (K ATP ) channel openers, optionally in combination with growth hormone, to subjects to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic, and compositional outcomes in the treatment of diseases or conditions involving K ATP channels. Also provided are pharmaceutical formulations, methods of administration, and methods of dosing K ATP channel openers to achieve these outcomes and to reduce the incidence of adverse effects in treated individuals. Also provided are methods of co-administering K ATP channel openers with other drugs, e.g., in combination with growth hormone, to treat diseases in humans and animals, e.g., Prader-Willi Syndrome (PWS), Smith-Magenis Syndrome (SMS), etc.

The invention discloses an intelligent temperature control health care patch and a preparation method thereof, and belongs to the technical field of medical instruments. The health care patch comprises a surface layer (a CO2 laser drilling PET film and a fluorosilane coating), a temperature control layer (paraffin / mesoporous silica composite phase change material), a medicine layer (wormwood essential oil-paraffin / sodium alginate microcapsules) and a bonding layer (silicone adhesive / hydrogenated castor oil). Ventilation and sweat prevention are achieved through the laser micropores and the hydrophobic coating, the phase change material composite system provides + / -1.4 DEG C temperature control precision, and the 48-hour medicine volatilization loss rate is only 3.2%. The preparation method adopts vacuum impregnation, low-temperature crosslinking and gradient curing processes, and interlayer bubble-free combination and efficient production are realized. The product has thermal therapy accuracy, medicine long-acting slow release property and skin adaptability, and is suitable for the field of chronic pain and joint nursing.

A chitosan-heparin nanomotor and a method for producing same are disclosed. A STING agonist-encapsulated urease-based chitosan-heparin nanomotor delivers the STING agonist directly to bladder mucosal cells in the bladder, and thus can induce an immune response.

Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice. The disclosed oral dosage forms provide once-a-day dosing of apremilast and are suitable for treating diseases or disorders ameliorated by inhibiting phosphodiesterase subtype IV (PDE4).

The present application relates to a kind of traditional Chinese medicine composition for regulating irregular menstruation, traditional Chinese medicine powder bag and ironing heating bag.The traditional Chinese medicine composition includes the following weight parts components: 7-11 parts of raw rehmannia, 7-11 parts of Guangyujin, 1-5 parts of licorice, 7-11 parts of medlar, 4-8 parts of dried tangerine or orange peel, 7-11 parts of kudzu root, 7-11 parts of white atractylodes, 1-5 parts of sanqi.The ironing heating bag includes traditional Chinese medicine powder bag, heating layer and support, and the traditional Chinese medicine powder bag, heating layer and support are sequentially bonded to form sandwich structure;The ironing heating bag is attached to the user's abdominal segment of belt pulse.Compared with prior art, the traditional Chinese medicine composition and ironing heating bag of the present application act on human body belt pulse, have the effects of warming meridian and dispelling cold, promoting blood circulation to remove blood stasis, regulating belt pulse, and have significant curative effect on irregular menstrual cycle, less menstrual flow, blood stasis, dysmenorrhea, amenorrhea and other symptoms.

The present application relates to a polymer and a composition thereof, and specifically provides a thermosensitive polymer represented by formula (I-2) and a preparation method therefor, and a pharmaceutical composition containing same, the polymer having a star-shaped multi-arm structure, and comprising an aromatic core and a biodegradable AB-type amphiphilic copolymer. The polymer can enhance the solubility and stability of a drug or a bioactive agent and control the release of the drug or the bioactive agent. The definition of each group in formula (I-2) is the same as in the description.

A delayed timed release pharmaceutical composition, a preparation method therefor, and use thereof. The pharmaceutical composition comprises a tablet core. The tablet core comprises a drug-containing layer and a boosting layer stacked on the drug-containing layer. The drug-containing layer comprises a drug active ingredient. The drug active ingredient is levodopa or a derivative thereof, or a mixture of levodopa or a derivative thereof and a DOPA decarboxylase inhibitor, and accounts for 5-72.5 wt% of the content of the drug-containing layer. The pharmaceutical composition is a capsule-shaped tablet, can realize the effects of 1-3 h delayed release of the drug active ingredient and reaching a peak concentration at 6-10 h, can be used for reducing morning stiffness in patients with Parkinson's disease, and has good application prospects.

The present invention can provide: a colon purgation tablet having a gel-forming coating layer containing an alginate as a main component, the gel-forming coating layer being introduced into an uncoated tablet containing an osmotic substance, the present invention relates to an uncoated tablet, and more particularly, to an uncoated tablet, such that the osmotic substance contained in the uncoated tablet disintegrates rapidly while preventing damage to gastric mucosa due to a physical collision between the tablet and the gastric mucosa, and thus provides an excellent intestinal cleansing effect. The colon purgation tablet according to the present invention can exhibit an excellent intestinal cleansing effect even at a small dose, and can further improve drug compliance by selectively miniaturizing the tablet or introducing an adhesive to improve a coating layer.

This invention discloses a substitute smoke for seawater vegetables and its application device, relating to the technical field of substitute smoke for seawater vegetables. To improve ease of use, the device includes a grip base. Two connecting frames are fixed to the outer bottom wall of the grip base by screws. The inner walls of the two connecting frames are rotatably connected to the same wheel via a central shaft. A rubber ring is provided between the outer circumference of the central shaft and the inner wall of the connecting frames. The wheel is integrally provided with evenly distributed circumferentially distributed movable receiving tubes. The substitute smoke for seawater vegetables, by weight, comprises: 30-50 parts of Suaeda salsa, 15-25 parts of Artemisia argyi, and 5-10 parts of Lonicera japonica. This invention, through the design of the grip base and wheel, allows for the storage of multiple moxibustion sticks using the wheel, facilitating replacement. Furthermore, when the moxibustion stick is pushed into the fixed receiving tube, it acts as a pin, limiting the wheel's movement and preventing rotation, thus improving practicality.

The invention provides a volatile oil adsorption carrier, and a preparation method and application thereof, the volatile oil adsorption carrier comprises the following components by mass: 60% of a hydrophobic core (based on the total amount of the carrier), and the hydrophobic core is composed of hydrophobic mesoporous silica and a Fe3O4 molecular plug. Wherein the hydrophobic mesoporous silica accounts for 54-59 parts, and the Fe3O4 molecular plug accounts for 1-6 parts. Wherein the specific surface area of hydrophobic mesoporous silica is greater than or equal to 800 m < 2 > / g, and the aperture is 5-10 nm The particle size of the Fe3O4 molecular plug is 5-8 nm, and the Fe3O4 molecular plug is embedded into the pore inlet of the hydrophobic mesoporous silica. And 40% of a cross-linked lipophilic shell. The volatile oil adsorption carrier provided by the invention has a biphasic core-shell structure with a hydrophobic core and a cross-linked lipophilic shell, and realizes partition adsorption, hole blocking and oil locking, and swelling resistance and controlled release.

The invention discloses a moxa stick containing traditional Chinese medicine components for treating infertility and a preparation method of the moxa stick, relates to the technical field of traditional Chinese medicine instruments, and mainly solves the technical problem of low skin permeation efficiency of the medicine components in the moxibustion process. According to the technical scheme, the preparation method comprises the following steps: preparing traditional Chinese medicine powder consisting of angelica sinensis, prepared rehmannia root, semen cuscutae, fructus lycii, ligusticum wallichii, rhizoma cyperi, salvia miltiorrhiza and borneol according to specific parts by mass, and controlling the average particle size to be 10-50 microns; the moxa and the traditional Chinese medicine powder are mixed according to the mass ratio of (3-5): 1 to form a medicine core layer; the periphery of the medicine core layer is wrapped with a pure moxa heat conduction layer with the thickness of 2-4 mm; and finally, wrapping the periphery of the heat conduction layer with a mulberry paper barrier layer with the thickness of 0.1-0.3 mm. Through the combined action of the three-layer structure, the medicine release and heat conduction path is optimized, the medicine transdermal efficiency is remarkably improved, and the high-efficiency traditional Chinese medicine moxa stick for treating infertility is prepared.

The invention provides a compound traditional Chinese medicine bag for enhancing kidney meridian and a device and method based on warm stimulation and synergistic point penetration administration. The compound traditional Chinese medicine bag comprises the following components: 5-8 parts of herba epimedii, 3-5 parts of ginseng, 3-5 parts of cistanche, 4-8 parts of rhizoma polygonati, 3-5 parts of cornu cervi pantotrichum, 3-8 parts of moxa and 3-6 parts of ligusticum wallichii. The device comprises a flexible pad cover and a compound traditional Chinese medicine bag, a containing cavity is formed in the flexible pad cover, a temperature control system is arranged in the containing cavity, and bandages are arranged on the two sides of the flexible pad cover. The compound traditional Chinese medicine bag is in close contact with the Taixi acupoint and the Kunlun acupoint through the bandage and the flexible pad outer sleeve, the temperature of the compound traditional Chinese medicine bag is controlled through the temperature control system, the Taixi acupoint and the Kunlun acupoint are accurately stimulated, kidney tonifying and refreshing medicine components are synchronously released, and the synergistic effect of acupoint stimulation and point penetration administration is achieved. Through clinical verification, the method has remarkable advantages in the aspects of improving the sub-health state, boosting vigor and improving the working efficiency.

An orifice-free drug delivery device is provided. In an embodiment, the device includes a body having at least one water-permeable wall bounding a reservoir defined within the body. A drug formulation is disposed within the reservoir. The body has an elastic portion and at least one restraining plug closing off an opening of the body. The opening is in fluid communication with the reservoir, and the restraining plug contacts the elastic portion of the body and controls release of the drug from the device by the transient formation of one or more microchannels between the elastic portion of the body and the at least one restraining plug. The elastic portion may define an opening having an inner diameter, which is exceeded by the outer diameter of the restraining plug by at least 3 %.

The invention discloses a temperature-sensitive hot compress composition based on vegetable wax-traditional Chinese medicine compounding and a preparation method of the temperature-sensitive hot compress composition, and relates to the technical field of thermal therapy materials. The temperature-sensitive hot compress composition based on vegetable wax-traditional Chinese medicine compounding comprises the following components in parts by weight: 25-40 parts of paraffin, 10-18 parts of microcrystalline wax, 15-25 parts of a soft wax compound, 8-15 parts of mineral oil, 5-12 parts of vegetable compound oil, 10-18 parts of a traditional Chinese medicine active system and 0.3-1.5 parts of a natural preservative. The invention further provides a preparation method of the vegetable wax-traditional Chinese medicine compounded temperature-sensitive hot compress composition. The multi-stage phase change temperature zone is constructed, normal-temperature efficient loading of the traditional Chinese medicine is achieved, oxidation and deterioration of the vegetable oil are inhibited, and the problems of traditional Chinese medicine inactivation and vegetable oil oxidation caused by high-temperature preparation of traditional hot compress materials are effectively solved.

The invention provides a traditional Chinese medicine hot compress bag for relieving endoscopic postoperative pain and a preparation method of the traditional Chinese medicine hot compress bag, and belongs to the technical field of traditional Chinese medicine hot compress bags. The invention provides a traditional Chinese medicine composition for regulating spleen and stomach and activating meridians to stop pain. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 70 to 100 parts of liquorice root, 20 to 80 parts of rhizoma zingiberis, 20 to 80 parts of fructus evodiae, 20 to 80 parts of semen raphani, 20 to 80 parts of malt, 20 to 50 parts of cassia twig, 20 to 50 parts of fructus perillae and 10 to 30 parts of black prepared common monkshood daughter root. The traditional Chinese medicine composition provided by the invention has remarkable effects of regulating spleen and stomach and activating meridians to stop pain, and can play roles of astringing and inducing astringency, tonifying middle-Jiao and Qi, and dispersing blood stasis and relieving pain after being prepared into a traditional Chinese medicine Reyan bag. Due to the design of the self-heating device, the heating time of the traditional Chinese medicine hot compress bag is long, the heating power maintaining time is long, transdermal absorption of medicines in the traditional Chinese medicine hot compress bag is facilitated, and the pain after the endoscopic surgery can be remarkably relieved.

This invention relates to isolated polypeptides that are analogs of human amylin. The disclosed amylin analog polypeptides have beneficial physicochemical properties relative to endogenous amylin, such as longer elimination half-lives (t1 / 2) and improved solubility and thermal stability. This invention also relates to methods of using presently disclosed amylin analog polypeptides in a variety of therapeutic indications, as well as methods of producing the same. The disclosed amylin analog polypeptides are particularly useful in methods of treating metabolic diseases or disorders, such as types 1 and 2 diabetes, and providing weight loss.

To provide a medical device for controlled drug discharge including, but not limited to, a device that can be deployed in a bladder for discharging a drug into the bladder.SOLUTION: An implantable drug delivery device 200 includes: a housing 208 that defines a storage part 204; a first unit 202 inside the storage part; and a second unit 210 inside the storage part. The first unit 202 stores a drug. The second unit 210 stores a functional agent that promotes discharge of the drug. An intravesical drug delivery device 200 includes a housing 208 portion storing a drug preparation and a housing 208 portion storing an excipient, and is configured to discharge the drug according to a first discharge profile and discharge the excipient according to a second discharge profile. A method includes inserting any of these devices 200 to a patient, and discharging a drug from the device 200.SELECTED DRAWING: Figure 2

Disclosed in certain embodiments is a capsule comprising: a liquid filling material comprising an osmogen and an active agent; and a semipermeable anti-disintegration shell composition.

An embodiment relates to a system comprising a fluid chamber containing a fluid; an Active Wearable Medical Device (AWMD) comprising a permeability module configured to allow ingress of fluid from the fluid chamber to an osmotic agent chamber via a semi-permeable membrane to generate osmotic pressure; a piston that moves longitudinally in response to the osmotic pressure; a drug chamber comprising a drug and a valve module configured to enable one-way drug flow from the chamber to outside the AWMD; a sensor module to measure piston displacement and provide real-time data; and an electronic module configured to regulate drug ejection based on the displacement data, ensuring dose-to-dose volume variation remains within ±25%. A machine learning model triggers alerts if dosing deviates from threshold limits. A channel is fluidically coupled to the AWMD and delivers the drug to the subject. The AWMD is externally worn and not implanted.

A method of producing an oral osmotic pharmaceutical delivery system by using a statistical modeling. The method includes determining a desired average dissolution profile for the active pharmaceutical ingredient; and controlling tablet strength, acetyl content of the cellulose acetate and weight gain of the semi-permeable membrane of the tablet to produce a pharmaceutical batch of tablets having the desired dissolution profile.

Provided herein are methods of treatment, erdafitinib for use and use of erdafitinib for the treatment of bladder cancer harboring one or more FGFR alterations comprising locally delivering erdafitinib into the bladder of a patient.

The present invention relates to a pharmaceutical composition for use in the treatment of both low-grade and high-grade glioblastoma in a human subject. The composition comprises a synergistic combination of the following active agents: R-Ketorolac, Bumetanide, and Niflumic acid. This specific combination is designed to exert a synergistic therapeutic effect against glioblastoma by targeting multiple molecular pathways involved in tumor progression, inflammation, and ion transport. In a further aspect of the invention, there is provided a method for selecting a subpopulation of glioblastoma subjects who are responsive to the aforementioned treatment. This method comprises identifying genetic profiles predictive of a favorable therapeutic response to the combined administration of R-Ketorolac, Bumetanide, and Niflumic acid.

The invention discloses a medicinal moxa composition for preventing and treating atherosclerosis and suppurative bacterial infection co-disease. The medicinal moxa composition comprises coptis chinensis, radix rehmanniae, polygala tenuifolia, juncus effuses and moxa. The medicinal folium artemisiae argyi composition disclosed by the invention can be used for effectively preventing and treating atherosclerosis and skin suppurative bacterial infection co-diseases through a multi-target synergistic effect. The medicinal moxa composition has the core effects of clearing away heart-fire, inducing diuresis for treating stranguria and promoting blood circulation to remove meridian obstruction, and forms a complete treatment system which uses cold and warm as well as treats both symptoms and root causes by purging fire for removing toxin through coptis chinensis, clearing heat and cooling blood through radix rehmanniae, soothing nerves and promoting intelligence through polygala, inducing diuresis and conducting heat downward movement through juncus effuses and combining moxa floss for warming and dredging meridians, eliminating cold to stop pain, resisting bacteria and diminishing inflammation. By inhibiting inflammatory factors, regulating epithelial cell proliferation and reaction to oxidative stress, regulating fluid shear force, atherosclerosis and Kaposi sarcoma-related herpesvirus infection-related pathways and other mechanisms, the medicinal folium artemisiae argyi composition realizes synergistic prevention and treatment of atherosclerosis and skin infection, and provides a basis for co-disease treatment.

The disclosure relates generally to methods of treating central nervous system disorders using (1R,5S)-1-(naphthalen-2-yl)-3-azabicyclo[3.1.0]hexane (i.e. centanafadine) or a pharmaceutically acceptable salt thereof. More particularly, the disclosure relates to treating conditions affected by monoamine neurotransmitters.