110 results about "Biguanide" patented technology

The invention relates to the technical field of pharmaceutical preparations, in particular to a pure drug-based nano preparation constructed by super-solubilization of a natural polyphenol material and a biguanide drug and a preparation method of the pure drug-based nano preparation. The pure drug-based nano preparation constructed by super solubilization of the natural polyphenol material and the biguanide drug provided by the invention is composed of the natural polyphenol material and the biguanide drug, and a phenolic hydroxyl group of the natural polyphenol material and an amino group of the biguanide drug are self-assembled into the nano preparation through electrostatic interaction and hydrophilic and hydrophobic effects, namely the pure drug-based nano preparation. The mass ratio of the natural polyphenol material to the biguanide drug is 1: (0.0001-10000). The pure drug-based nano preparation provided by the invention has the advantages of high drug loading capacity, simple preparation process, greenness, high efficiency, safety and suitability for industrial application.

A composition is provided that includes hydrolyzed collagen, at least one biguanide, at least one vicinal diol, and at least one chelating agent. The composition exhibits at least 2-log reduction of planktonic microbes within 24 hours. Methods of using the composition are also provided.

Provided in the present invention are an antimicrobial whitening composition, a white synthetic leather substrate and a preparation method therefor, and an antimicrobial synthetic leather. The antimicrobial whitening composition comprises a cationic antimicrobial agent, an antimicrobial organic substance and a solvent, wherein the cationic antimicrobial agent comprises at least one of a polymeric quaternary ammonium compound, polyethyleneimine, chitosan, a biguanide compound and a polymeric biguanide; and the antimicrobial organic substance comprises at least one of a terpene compound and a derivative thereof, a phenolic compound, an essential oil, an antifungal agent, a preservative and a disinfectant. The man-made leather prepared by means of the antimicrobial whitening composition of the present invention has good performance in terms of both long-lasting antimicrobial properties and maintaining a high whiteness.

The present invention relates to ophthalmic formulations in which a synergistic combination of three different types of disinfectants (a polybiguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound), in particular a combination of polyhexamethylene biguanide, polyquaternium-1 and myristoylaminopropyl dimethylamine, high concentrations of hyaluronates are enabled to provide better comfort and support for corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of hyaluronates at concentrations greater than 7.5 times as high as currently commercially available multi-purpose disinfectants.

The invention discloses a polymer hydrophilic coating in the field of biomedical materials, a preparation method of the polymer hydrophilic coating and application of the polymer hydrophilic coating in medical catheters. The coating achieves excellent performance through the synergistic effect of two newly designed modified compounds. Wherein the phosphorylcholine silane functionalized polyethyleneimine is used as a matrix material and provides hydrophilicity and anticoagulant activity; and the nano silicon dioxide anchored polyhexamethylene biguanide is used as a functional filler, so that the coating is endowed with antibacterial property and mechanical enhancement. During preparation, all the components are sequentially dissolved in water to form a uniform solution, transparent sol is formed through silane hydrolysis, then the pretreated guide pipe is subjected to dip coating, and a final product is obtained through preheating, ultraviolet light curing and heat curing treatment. The coating obviously reduces the surface friction coefficient, has lasting hydrophilicity, efficient antibacterial property and excellent blood compatibility, is firmly combined with a base material, and is particularly suitable for surface functional modification of various interventional medical catheters.

The present invention relates to ophthalmic formulations wherein a synergistic combination of three different classes of disinfectants (a multimeric biguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound, in particular a combination of polyhexamethylene biguanide, Polyquaternium-1 and myristamidopropyl dimethylamine) enables the use of high concentrations of hyaluronate for providing better comfort and support of corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of more than 7.5 times higher concentrations of hyaluronate than are present in currently marketed multi-purpose disinfection solutions.

The invention discloses a phospholipid composition, a preparation method and application thereof and a phospholipid wet tissue, and relates to the technical field of daily necessities, the phospholipid composition is prepared from the following raw materials by mass: 0.1-2% of lecithin; 0.1%-2% of an organic solvent; 0.001% to 0.1% of vitamin; 0.01% to 0.2% of sodium hyaluronate; 0.1%-3% of trehalose; 0.4%-4% of a polyol compound; 0.001%-0.02% of a compositae herbaceous plant extract; 0.0001%-0.001% of polyhexamethylene biguanide, 0.0001%-0.001 And the balance water. The phospholipid composition not only has excellent stability, but also can remarkably relieve asthenopia and eye dryness symptoms, and is safe and non-irritant.

The invention relates to the technical field of disinfectants, in particular to a microorganism and nucleic acid removal material based on high-temperature stable sustained-release microspheres, a preparation method of the microorganism and nucleic acid removal material and application of the microorganism and nucleic acid removal material in a high-temperature condition. The microorganism and nucleic acid removal material based on the high-temperature stable sustained-release microspheres is prepared from an oil phase raw material, an inner water phase raw material and an outer water phase, the oil phase raw material comprises poly-L-lactic acid; the inner water phase raw material is a mixture of a cationic polymer and benzalkonium chloride; the cationic polymer comprises any two or three of polyhexamethylene biguanide, polyethyleneimine and chitosan. According to the invention, by optimizing the formula of the microorganism and nucleic acid removal material based on the high-temperature stable sustained-release microspheres, multiple advantages of high-temperature stability, efficient nucleic acid inactivation, accurate release, environmental friendliness, long-acting disinfection and the like are realized, and a brand-new, efficient and reliable solution is provided for the disinfection demand in a high-temperature environment.

The invention provides modified polyaluminum chloride with high phosphorus removal performance and a preparation method and application thereof, and belongs to the technical field of modified polyaluminum chloride. The preparation method comprises the following steps: firstly, reacting aluminum chloride, zirconium oxychloride and an alkaline regulator in a water phase to prepare an aluminum-zirconium complex mother solution, then adding a polyhexamethylene biguanide solution into the aluminum-zirconium complex mother solution, and realizing effective compounding of organic long-chain molecules and inorganic complexes under the actions of static electricity, coordination, hydrogen bonds and the like; finally, mannitol serving as a polyhydric alcohol stabilizer is introduced into the organic-inorganic composite system, and premature polymerization and precipitation of the product are inhibited by means of the chelation of mannitol on a metal center and the steric hindrance effect of mannitol on molecules; according to the invention, the complexation of zirconium ions and strong current neutralization of polyhexamethylene biguanide form synergy, the removal efficiency of phosphate is improved, the formed flocculating constituent is more compact and has high settling velocity, and the application range of the product under complex water quality conditions is widened.

This invention discloses a layer-by-layer deposition modified ultrafiltration membrane with both antifouling and antibacterial properties, its preparation method, and its applications. Through layer-by-layer assembly technology, a tannic acid (TA) anion layer and a polyhexamethylene biguanide (PHMB) cation layer are alternately deposited on the surface of an ultrafiltration membrane. Under weakly alkaline conditions, electrostatic interactions, hydrogen bonding, Schiff base reactions, and Michael addition reactions are simultaneously utilized to achieve both non-covalent and covalent bonding, constructing a stable and dense integrated antibacterial-antifouling composite coating. This coating has a contact-type antibacterial structure, which can effectively kill bacteria in water and inhibit biofilm formation at the source. Simultaneously, it significantly improves the hydrophilicity of the membrane surface, reduces pollutant adsorption and deposition, and achieves synergistic enhancement of antibacterial and antifouling properties. The preparation process of this invention is mild, simple, low-cost, and environmentally friendly. The modified membrane exhibits high flux retention, excellent separation performance, and excellent operational stability, and can be widely applied in water treatment scenarios such as municipal wastewater treatment.

The invention belongs to the technical field of medical dressings, and discloses a recombinant human collagen combined nano-silver ionic liquid-containing dressing and a preparation method thereof. The invention discloses a liquid dressing. Comprising the following raw materials: 8 to 15 parts of polyvinyl alcohol, 3 to 6 parts of calcium alginate, 1 to 3 parts of polydimethylsiloxane, 0.1 to 0.5 part of an antibacterial agent, 2 to 5 parts of bioactive protein, 1 to 4 parts of sodium hyaluronate, 2 to 5 parts of chitosan, 0.5 to 2 parts of tranexamic acid, 0.3 to 1 part of polypeptide, 0.2 to 0.8 part of an anti-inflammatory agent, 0.5 to 1.5 parts of ethylhexylglycerin, 10 to 20 parts of glycerin, 0.5 to 1.2 parts of carbomer, 0.1 to 0.3 part of biguanide hydrochloride and 40 to 60 parts of deionized water. The comprehensive improvement of the liquid dressing on the aspects of antibiosis, repair promotion, stability and safety is realized. All the components are matched to achieve the effects of broad-spectrum antibacterial property, healing time shortening and activity protection. Temperature gradient control, microwave activation and high-pressure homogenization are adopted in the process, the compatibility of all the raw materials is improved, the dressing is stable in physical performance, free of layering during storage and high in safety, and the requirements for skin wound protection and repair are met.

The invention discloses a hydraulic antibacterial paste material as well as a preparation method and application thereof. The hydrogel antibacterial paste material is obtained by mixing a powder raw material and a liquid raw material which accounts for 30-35 wt% of the mass of the powder raw material, the hydrogel antibacterial paste material comprises the following components in percentage by mass of the powder raw material: 20-40 wt% of a calcium silicate compound, 5-40 wt% of a calcium phosphate compound, 10-40 wt% of a radiation-resistant material and 0.2-0.4 wt% of a macromolecular antibacterial agent, and the macromolecular antibacterial agent is polyhexamethylene biguanide salt. The injectable hydrogel antibacterial paste material can be used for preparing orthopedic or dental filling materials. Compared with the prior art, the antibacterial paste material not only can be self-cured, but also has excellent antibacterial performance, the preparation method is simple and quick, and the antibacterial paste material can be applied to the field of dental or orthopedic repair.

Provided in the present invention are an antimicrobial whitening composition, a white synthetic leather substrate and a preparation method therefor, and an antimicrobial synthetic leather. The antimicrobial whitening composition comprises a cationic antimicrobial agent, an antimicrobial organic substance and a solvent, wherein the cationic antimicrobial agent comprises at least one of a polymeric quaternary ammonium compound, polyethyleneimine, chitosan, a biguanide compound and a polymeric biguanide; and the antimicrobial organic substance comprises at least one of a terpene compound and a derivative thereof, a phenolic compound, an essential oil, an antifungal agent, a preservative and a disinfectant. The man-made leather prepared by means of the antimicrobial whitening composition of the present invention has good performance in terms of both long-lasting antimicrobial properties and maintaining a high whiteness.

The application discloses a kind of organic metal catalyst based on biguanide-based ligand and its preparation method and application, belong to polymer material field.The organic metal catalyst is by the ligand with biguanide-based structure and magnesium salt coordination and form.The preparation method of the application is simple, condition is mild, the obtained organic metal catalyst is with magnesium as metal center, its toxicity is lower, catalytic activity is high, can successfully catalyze cyclic lactone under solvent or solvent-free condition ring-opening polymerization reaction, and product molecular weight is high, distribution is narrow.

The invention discloses a flame-retardant wood-plastic plate and a preparation method thereof, and relates to the technical field of wood-plastic plates. The flame-retardant wood-plastic plate prepared by the invention comprises modified polyethylene and modified wood flour, and the modified polyethylene is obtained by grafting a functional monomer to polyethylene and then reacting with phosphorus pentoxide; the modified wood flour is obtained by wrapping wood flour with polyether amine and then reacting with o-tolyl biguanide, and the prepared flame-retardant wood-plastic plate has good flame-retardant, antibacterial and anti-aging properties.

The invention relates to the technical field of coating preparation, in particular to a preparation method of kerosene-resistant antibacterial static conductive coating. The invention relates to a preparation method of a kerosene-resistant antibacterial static conductive coating. The kerosene-resistant antibacterial static conductive coating comprises a component A raw material and a component B raw material, the component A is prepared from the following raw materials: novolac epoxy resin, toughened modified resin, a reactive diluent, an auxiliary agent, polyhexamethylene biguanide, an anti-rust filler and a solvent; and the component B comprises the following raw materials: a toughening phenolic aldehyde amine curing agent and an alicyclic amine curing agent. The preparation method of the kerosene-resistant antibacterial static conductive coating has the advantages that the phenomena of bubbling and shedding are avoided, the coating has a protection effect and stable salt spray resistance and surface resistivity, and the static conductive requirement is met. The antibacterial rate is increased, the surface pollution is effectively inhibited, the green chemical industry standard is met, the adhesive force of the coating is improved, the wear resistance is improved, and high toughness can be kept in a low-temperature state.

An ophthalmic composition according to the present invention contains (A) 0.01-0.5 w / w% of a copolymer having constituent units represented by formula (1a) to formula (1c), where the molar ratio of each constituent unit is a:b:c=100:10-400:2-50 and the weight average molecular weight is 5,000-2,000,000, (B) 0.000001-0.0001 w / w% of polyhexamethylene biguanide represented by formula (2) or a salt thereof, and (C) 0.02-5.0 w / w% of polyoxyethylene hydrogenated castor oil and / or (D) 0.02-5.0 w / w% of polyoxyethylene glycol monostearate.　According to the present invention, it is possible to provide an ophthalmic composition that exhibits sufficient preservation efficacy and has high lubricity.

Compositions and methods for the treatment of inflammatory skin diseases. The compositions include a pharmaceutically effective amount of polyhexamethylene biguanide (PHMB), polyaminopropyl biguanide (PAPB), and / or chlorhexidine (CHG) in a petrolatum carrier.

The invention relates to the technical field of preparation of polyhexamethylene biguanide, in particular to a synthesis method of polyhexamethylene biguanide, which comprises the following steps: S1, dissolving 1, 6-hexamethylenediamine hydrochloride in a solvent, and adjusting the pH value to weak acidity; s2, adding 1, 6-bis-cyano guanidino hexane into S1, carrying out prepolymerization, and then heating to remove the solvent; s3, carrying out heat preservation treatment on the reaction system in S2, then adding a solvent, and carrying out stirring treatment; and S4, heating the reaction system in S3 to remove the solvent, thereby obtaining the polyhexamethylene biguanide. According to the method provided by the invention, the solvent is evaporated out after prepolymerization, the reaction system is in a molten resin shape, and the polymerization degrees are different due to the fact that no solvent exists and all parts are heated unevenly, so that the polymer can be dispersed evenly again and then react continuously in the mode, and the polymer with uniform molecular weight distribution is obtained.

The invention discloses a nanofiltration composite membrane with interspersed rigid and flexible structures as well as a preparation method and application of the nanofiltration composite membrane. The thickness of the film is 1-500 nm; the polymer is obtained by in-situ polymerization of polybasic organic amine and rigid biguanide monomers on a porous support layer; a biguanide monomer with a rigid structure, high positive charge density and a low interface mass transfer energy barrier is embedded and expands a flexible and tightly-wound polyamide network, a continuous semi-permanent microcavity with rigidity and softness, high positive charge density is constructed in a functional layer, and a transmission channel of water molecules is expanded. The membrane has higher water permeability and magnesium-lithium selectivity, the preparation process is simple and easy to operate, and large-scale production and application are facilitated.

This invention generally pertains to antibodies and antigen-binding fragments thereof, e.g., humanized, chimeric, and human antibodies and antigen-binding fragments thereof, and fusion proteins, compositions containing such antibodies and antigen-binding fragments thereof and fusion proteins, wherein such antibodies and antigen-binding fragments thereof and fusion proteins specifically bind to MCT1, e.g., human or non-human MCT1 and antagonize, inhibit or block one or more MCT1-associated functions in vitro and / or in vivo. The invention also relates to therapeutic and diagnostic uses of these anti-MCT1 antibodies, antigen-binding fragments, fusion proteins and compositions containing optionally wherein these anti-MCT1 antibodies, antigen-binding fragments, fusion proteins and compositions containing are used in therapeutic regimens that further include the administration of other therapeutic agents, e.g., mitochondrial inhibitors and / or biguanides or small molecule MCT1 inhibitors.

The invention relates to the technical field of sterilization and antifogging, in particular to a microsphere-based antibacterial and antifogging additive, a preparation method thereof, a multifunctional coating and application. The microsphere-based antibacterial and antifogging additive is a liposome vesicle microsphere, and the liposome vesicle microsphere is prepared from an oil-phase raw material and a water-phase raw material; the oil phase raw material comprises one or more of distearoyl phosphatidylcholine, hydrogenated lecithin and cholesterol; the water-phase raw material is a mixture of polyhexamethylene biguanide, polyethyleneimine and benzalkonium chloride; in the water phase raw material, the content of the polyhexamethylene biguanide is 25wt%-45wt%. By optimizing the formula of the microspheres, the efficiency and effect of killing nucleic acid can be remarkably improved, and the fog-resistant and anti-fog effects are achieved.

The invention relates to the technical field of disinfectants, in particular to environment-control double-layer composite microbe removal microspheres and a preparation method thereof. The environment-control double-layer composite microbe removal microsphere comprises an inner core and a shell wrapping the inner core, the inner core is prepared from water, nano disinfection microspheres and a stabilizer, and the shell is prepared from an organic solvent and polylactic acid; the nano disinfection microspheres are prepared from an oil-phase raw material and a water-phase raw material, the oil phase raw materials comprise hydrogenated lecithin, distearoyl phosphatidylcholine and cholesterol; the water-phase raw materials comprise polyethyleneimine, polyhexamethylene biguanide and benzalkonium chloride. According to the environment-control double-layer composite microbe removal microsphere, through unique structural design, the nanometer disinfection microsphere in the inner core is prepared from specific oil-phase and water-phase raw materials, various pathogens can be effectively killed, and the polylactic acid structure of the shell provides good stability and slow release performance for the microsphere, so that the environment-control double-layer composite microbe removal microsphere has a good application prospect. And the duration of the disinfection effect is prolonged.

The invention discloses a non-irritant multipurpose long-acting degerming liquid, which is prepared from the following ingredients in percentage by mass: 0.1 to 0.5 percent of cationic polymer antibacterial agents, 1 to 4 percent of quaternary ammonium salt surfactants A, 0.5 to 2 percent of quaternary ammonium salt surfactants B, 1.5 to 5 percent of polyhydric alcohol humectants, 0.1 to 2 percent of alcohol solvents, 0.3 to 1 percent of plant natural polyphenols and 0.5 to 2 percent of optional essence. And the balance of deionized water. Wherein the cationic polymer antibacterial agent is preferably selected from polyhexamethylene biguanide hydrochloride (PHMB), and the quaternary ammonium salt surfactant is preferably selected from dodecyl dimethyl benzyl ammonium chloride (DDBAC) and tetradecyl dimethyl benzyl ammonium chloride (TDBAC). The benzalkonium chloride and the PHMB biguanide system are perfectly combined, efficient sterilization and disinfection are achieved, and meanwhile the long-acting antibacterial effect is achieved. The product contains natural plant components such as sugarcane essence, can effectively neutralize acidic peculiar smells such as sweat smell and foot odor, realizes zero irritation, and is especially suitable for people with sensitive skin and alcohol allergy.

The invention relates to the technical field of thin film preparation, in particular to a biguanide molecule modified broadband gap perovskite solar cell and a preparation method thereof. The cell comprises a conductive glass layer, a hole transport layer, a broadband gap perovskite light absorption layer, an interface modification layer, an electron transport layer, an electron blocking layer and a metal electrode. Wherein the broadband gap perovskite light absorption layer is an FA0. 8Cs0. 2Pb (I2. 4Br0. 6) thin film layer, and the interface modification layer is formed by spin coating and annealing of a phenformin hydrochloride solution. The biguanide molecule inhibits non-radiative recombination and enhances environmental stability, Br <-> in FA0. 8Cs0. 2Pb (I2.4Br0. 6) enables crystal lattices to shrink, and Br <-> and phenformin hydrophobic protection cooperate to inhibit phase separation and humidity degradation, improve film forming quality and enhance film layer stability, thereby improving photoelectric conversion efficiency of the broadband gap perovskite solar cell.

To provide a composition for use in the treatment or prevention of pathogenic infections, rosacea, eczema and psoriasis in humans or animals.SOLUTION: There is provided a composition comprising benzalkonium halide; didecyldimethylammonium halide; polyhexamethylene biguanide salt; bronopol; and p-chloro-m-cresol.SELECTED DRAWING: None

The invention discloses a phosphogypsum-based anti-mildew wall material and a preparation method thereof, and belongs to the technical field of building materials and solid waste recycling. The wall material is prepared from the following raw materials in parts by weight: 100 parts of phosphogypsum, 2 to 4 parts of calcium oxide, 10 to 20 parts of slag, 5 to 10 parts of aluminate cement, 0.1 to 1 part of tetradecyl trimethyl ammonium chloride and 0.1 to 0.5 part of polyhexamethylene biguanide. According to the invention, an organic anti-mildew system compounded by TTAC and PHMB is constructed, a CaO-slag-aluminate cement alkaline excitation gelling system is coupled, and a compact pore structure and an alkaline environment formed by an electrostatic anchoring and hydrogen bond crosslinking mechanism is utilized to stabilize and immobilize an anti-mildew agent and cooperating with a gelling product, so that a triple anti-mildew mechanism of physical barrier, chemical slow release and alkaline inhibition is constructed. The obtained material keeps 0-grade mildew resistance in a high-humidity environment for 28 days, the compressive strength reaches 11.7 MPa, the softening coefficient is increased to 0.68, the material has excellent mildew resistance durability and mechanical property, and a new way is provided for high-value-added resource utilization of phosphogypsum.

Compositions and methods are provided for the synthesis and use of biguanide-conjugated antibiotics, which provide a generalizable strategy for rapidly synthesizing potent antibiotics derived from clinically relevant agents.

The application relates to the technical field of photocatalytic materials, and discloses an aromatic biguanide-based covalent organic framework material, which is obtained through C-N coupling reaction of an organic framework material containing halogen atoms and an aromatic biguanide compound; wherein the molar ratio of the organic framework material containing halogen atoms to the aromatic biguanide compound is 1:7.5-15. The aromatic biguanide-based covalent organic framework material is constructed through side chain engineering, can efficiently catalyze drug micro-pollutants in water under visible light irradiation, realizes in-situ photocatalytic self-cleaning at the same time, the degradation products can effectively separate from the pores and the surface of the aromatic biguanide-based covalent organic framework material, active sites are released, and steps such as organic solvent elution are avoided, so that the application has certain reference function for the design and development of efficient green photocatalysts.

According to the preparation method, indene amine and dicyandiamide are used as reactants, magnesium-aluminum hydrotalcite is used as a catalyst, a biguanide intermediate is obtained through a reaction in an organic solvent, the Mg / Al molar ratio of the magnesium-aluminum hydrotalcite is 3: 1-4: 1, and the magnesium-aluminum hydrotalcite is roasted and activated at the temperature of 400-500 DEG C; and reacting the biguanide intermediate with R-2-methyl fluoropropionate, so as to generate the indaziflam. According to the present invention, the activated magnesium-aluminum hydrotalcite is adopted as the catalyst to prepare the indaziflam, such that the aluminum-containing wastewater can be avoided, the property of the biguanide intermediate generated through the reaction is stable, and the purity and the yield of the prepared indaziflam are high.