157 results about "Biguanide" patented technology

The invention belongs to the technical field of solar cells, and particularly relates to a fluorinated biguanide salt synergistically passivated perovskite solar cell and a preparation method thereof. The method comprises the following steps: S1, coating the surface of a perovskite light absorption layer with a fluorinated biguanide hydrochloride solution to form a synergistic layer; coating the surface of the synergistic layer with a halogenated phenylethylamine solution to form a synergistic passivation layer; and S2, arranging an electron transport layer and a hole blocking layer on the surface of the passivation layer. According to the invention, the synergistic passivation layer is introduced in the preparation process of the perovskite solar cell. The introduction of the fluorinated biguanide salt passivation layer can modify the perovskite crystal and generate the low-dimensional perovskite at the crystal boundary, and the second passivation layer can interact with the low-dimensional perovskite structure, thereby further protecting the perovskite film, improving the interface of the perovskite light absorption layer and the electron transport layer, and improving the short-circuit current density, open-circuit voltage and cell efficiency of the cell.

The invention discloses a preparation method and application of a functional nano-pesticide based on a random combinatorial library of polyhexamethylene biguanide hydrochloride analogues and phenolic hydroxyl group-containing natural small molecules. A PHMB analogue containing a mono-guanidyl or biguanidyl structure and a natural small molecule compound with 1-3 phenolic hydroxyl structures are selected, nano-particles with good dispersion coefficients can be formed in a sodium hydroxide aqueous solution with the pH value of 9-11 without additional carriers or stabilizers, and the limitation that traditional nano-pesticides depend on macromolecular carriers is broken through. The obtained nano-particles can be enriched on the surface of a plant pathogenic fungus cell membrane by utilizing the electrostatic adsorption effect of guanidyl, and the delivery effect of natural small molecules is enhanced, so that the antifungal activity of the nano-particles is improved. An antibacterial experiment result shows that part of the composition has a synergistic antibacterial effect on fusarium graminearum, and the diameter of an inhibition zone is superior to that of a single component. The method is high in construction efficiency, has good expansibility, can form a nano pesticide preparation library, and is suitable for plant disease prevention and control and environment-friendly material development.

A cleansing wet wipe in which a base paper sheet is impregnated with a chemical liquid. The chemical liquid contains at least iodopropynyl butylcarbamate, polyamino-propyl biguanide, benzalkonium chloride, and cetylpyridinium chloride; and the content value for the iodopropynyl butylcarbamate in the chemical liquid is 0.005-0.02 mass % inclusive. The chemical liquid is adjusted to be acidic.

The invention relates to the technical field of pharmaceutical preparations, in particular to a pure drug-based nano preparation constructed by super-solubilization of a natural polyphenol material and a biguanide drug and a preparation method of the pure drug-based nano preparation. The pure drug-based nano preparation constructed by super solubilization of the natural polyphenol material and the biguanide drug provided by the invention is composed of the natural polyphenol material and the biguanide drug, and a phenolic hydroxyl group of the natural polyphenol material and an amino group of the biguanide drug are self-assembled into the nano preparation through electrostatic interaction and hydrophilic and hydrophobic effects, namely the pure drug-based nano preparation. The mass ratio of the natural polyphenol material to the biguanide drug is 1: (0.0001-10000). The pure drug-based nano preparation provided by the invention has the advantages of high drug loading capacity, simple preparation process, greenness, high efficiency, safety and suitability for industrial application.

The invention provides antibacterial and antifogging glasses wiping cloth and a preparation method thereof, and relates to the technical field of glasses cleaning. Comprising a base material layer, the base material layer is a fiber fabric internally provided with a micropore structure, the fiber fabric is formed by blending sea-island fibers and bamboo charcoal fibers, an antibacterial layer is arranged on the surface of the base material layer, an anti-fog layer is sprayed on the surface of the base material layer, and the antibacterial layer is formed after the base material layer is soaked in composite antibacterial liquid and cured. The composite antibacterial liquid comprises quaternary ammonium salt modified chitosan and polyhexamethylene biguanide, the quaternary ammonium salt modified chitosan is covalently bonded with the fiber surface through an epoxy group cross-linking agent, the polyhexamethylene biguanide is dispersed in the microporous structure, and the anti-fog layer is formed by a sulfobetaine methacrylate polymer grafted on the surface of the base material layer. And a modified nano TiO2-SiO2 core-shell structure is embedded in the zwitterionic polymer. The 24-hour antibacterial rate of the glasses wiping cloth is greater than 99%; after 50 times of standard washing, the antibacterial rate is still greater than or equal to 95%; the antifogging duration is longer than or equal to 33 days and far exceeds that of a temporary coating.

A composition is provided that includes hydrolyzed collagen, at least one biguanide, at least one vicinal diol, and at least one chelating agent. The composition exhibits at least 2-log reduction of planktonic microbes within 24 hours. Methods of using the composition are also provided.

Provided in the present invention are an antimicrobial whitening composition, a white synthetic leather substrate and a preparation method therefor, and an antimicrobial synthetic leather. The antimicrobial whitening composition comprises a cationic antimicrobial agent, an antimicrobial organic substance and a solvent, wherein the cationic antimicrobial agent comprises at least one of a polymeric quaternary ammonium compound, polyethyleneimine, chitosan, a biguanide compound and a polymeric biguanide; and the antimicrobial organic substance comprises at least one of a terpene compound and a derivative thereof, a phenolic compound, an essential oil, an antifungal agent, a preservative and a disinfectant. The man-made leather prepared by means of the antimicrobial whitening composition of the present invention has good performance in terms of both long-lasting antimicrobial properties and maintaining a high whiteness.

The present invention relates to ophthalmic formulations in which a synergistic combination of three different types of disinfectants (a polybiguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound), in particular a combination of polyhexamethylene biguanide, polyquaternium-1 and myristoylaminopropyl dimethylamine, high concentrations of hyaluronates are enabled to provide better comfort and support for corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of hyaluronates at concentrations greater than 7.5 times as high as currently commercially available multi-purpose disinfectants.

The invention discloses a polymer hydrophilic coating in the field of biomedical materials, a preparation method of the polymer hydrophilic coating and application of the polymer hydrophilic coating in medical catheters. The coating achieves excellent performance through the synergistic effect of two newly designed modified compounds. Wherein the phosphorylcholine silane functionalized polyethyleneimine is used as a matrix material and provides hydrophilicity and anticoagulant activity; and the nano silicon dioxide anchored polyhexamethylene biguanide is used as a functional filler, so that the coating is endowed with antibacterial property and mechanical enhancement. During preparation, all the components are sequentially dissolved in water to form a uniform solution, transparent sol is formed through silane hydrolysis, then the pretreated guide pipe is subjected to dip coating, and a final product is obtained through preheating, ultraviolet light curing and heat curing treatment. The coating obviously reduces the surface friction coefficient, has lasting hydrophilicity, efficient antibacterial property and excellent blood compatibility, is firmly combined with a base material, and is particularly suitable for surface functional modification of various interventional medical catheters.

Compositions and methods for the treatment of inflammatory skin diseases. The compositions include a pharmaceutically effective amount of polyhexamethylene biguanide (PHMB), polyaminopropyl biguanide (PAPB), and / or chlorhexidine (CHG) in a petrolatum carrier.

The present invention relates to ophthalmic formulations wherein a synergistic combination of three different classes of disinfectants (a multimeric biguanide compound, a quaternary ammonium compound and an antifungal / anti-acanthamoeba compound, in particular a combination of polyhexamethylene biguanide, Polyquaternium-1 and myristamidopropyl dimethylamine) enables the use of high concentrations of hyaluronate for providing better comfort and support of corneal health without compromising antimicrobial efficacy. The novel ophthalmic formulations support the use of more than 7.5 times higher concentrations of hyaluronate than are present in currently marketed multi-purpose disinfection solutions.

The invention discloses a phospholipid composition, a preparation method and application thereof and a phospholipid wet tissue, and relates to the technical field of daily necessities, the phospholipid composition is prepared from the following raw materials by mass: 0.1-2% of lecithin; 0.1%-2% of an organic solvent; 0.001% to 0.1% of vitamin; 0.01% to 0.2% of sodium hyaluronate; 0.1%-3% of trehalose; 0.4%-4% of a polyol compound; 0.001%-0.02% of a compositae herbaceous plant extract; 0.0001%-0.001% of polyhexamethylene biguanide, 0.0001%-0.001 And the balance water. The phospholipid composition not only has excellent stability, but also can remarkably relieve asthenopia and eye dryness symptoms, and is safe and non-irritant.

The invention discloses multifunctional composite hydrogel for integrally treating infected wounds as well as a preparation method and application of the multifunctional composite hydrogel, and belongs to the technical field of medicines. The multifunctional composite hydrogel for integrally treating infected wounds is prepared from the following raw materials: polyhexamethylene biguanide grafted silk fibroin, acrylamide, N-isopropylacrylamide, salidroside, N, N-dimethylformamide, polyhexamethylene biguanide grafted polyhexamethylene biguanide grafted polyhexamethylene biguanide grafted polyhexamethylene biguanide grafted polyhexamethylene biguanide grafted polyhexamethylene biguanide grafted polyhexamethylene The composite hydrogel is prepared from N, N '-methylene bisacrylamide and water, has multiple functions including high air permeability, high tensile resistance, high adhesion, injectability, self-healing property and multiple responsiveness, and meets the mechanical property requirement of wound dressing and the biological requirement for promoting healing of infected wounds. The composite hydrogel has treatment effects in different stages of wound healing, and can integrally and efficiently solve the problems of slow healing of infected wounds, high scar formation risk and the like.

The invention discloses a collagen / PVA hydrogel wound dressing as well as a preparation method and application thereof. Collagen and PVA are used as matrixes, borax is used as a cross-linking agent, hydroxypropyl methyl cellulose is used as a thickening agent, polyhexamethylene biguanide is introduced as an antibacterial agent, and the hydrogel wound dressing is obtained through boric acid ester bond formation and electrostatic interaction. The collagen / PVA hydrogel wound dressing prepared by the invention has dynamic joint adhesion, cyclic plasticity, rapid self-healing property, super stretchability and antibacterial property, and can be applied as a hydrogel wound dressing.

The invention relates to the technical field of disinfectants, in particular to a microorganism and nucleic acid removal material based on high-temperature stable sustained-release microspheres, a preparation method of the microorganism and nucleic acid removal material and application of the microorganism and nucleic acid removal material in a high-temperature condition. The microorganism and nucleic acid removal material based on the high-temperature stable sustained-release microspheres is prepared from an oil phase raw material, an inner water phase raw material and an outer water phase, the oil phase raw material comprises poly-L-lactic acid; the inner water phase raw material is a mixture of a cationic polymer and benzalkonium chloride; the cationic polymer comprises any two or three of polyhexamethylene biguanide, polyethyleneimine and chitosan. According to the invention, by optimizing the formula of the microorganism and nucleic acid removal material based on the high-temperature stable sustained-release microspheres, multiple advantages of high-temperature stability, efficient nucleic acid inactivation, accurate release, environmental friendliness, long-acting disinfection and the like are realized, and a brand-new, efficient and reliable solution is provided for the disinfection demand in a high-temperature environment.

The invention provides modified polyaluminum chloride with high phosphorus removal performance and a preparation method and application thereof, and belongs to the technical field of modified polyaluminum chloride. The preparation method comprises the following steps: firstly, reacting aluminum chloride, zirconium oxychloride and an alkaline regulator in a water phase to prepare an aluminum-zirconium complex mother solution, then adding a polyhexamethylene biguanide solution into the aluminum-zirconium complex mother solution, and realizing effective compounding of organic long-chain molecules and inorganic complexes under the actions of static electricity, coordination, hydrogen bonds and the like; finally, mannitol serving as a polyhydric alcohol stabilizer is introduced into the organic-inorganic composite system, and premature polymerization and precipitation of the product are inhibited by means of the chelation of mannitol on a metal center and the steric hindrance effect of mannitol on molecules; according to the invention, the complexation of zirconium ions and strong current neutralization of polyhexamethylene biguanide form synergy, the removal efficiency of phosphate is improved, the formed flocculating constituent is more compact and has high settling velocity, and the application range of the product under complex water quality conditions is widened.

This invention discloses a layer-by-layer deposition modified ultrafiltration membrane with both antifouling and antibacterial properties, its preparation method, and its applications. Through layer-by-layer assembly technology, a tannic acid (TA) anion layer and a polyhexamethylene biguanide (PHMB) cation layer are alternately deposited on the surface of an ultrafiltration membrane. Under weakly alkaline conditions, electrostatic interactions, hydrogen bonding, Schiff base reactions, and Michael addition reactions are simultaneously utilized to achieve both non-covalent and covalent bonding, constructing a stable and dense integrated antibacterial-antifouling composite coating. This coating has a contact-type antibacterial structure, which can effectively kill bacteria in water and inhibit biofilm formation at the source. Simultaneously, it significantly improves the hydrophilicity of the membrane surface, reduces pollutant adsorption and deposition, and achieves synergistic enhancement of antibacterial and antifouling properties. The preparation process of this invention is mild, simple, low-cost, and environmentally friendly. The modified membrane exhibits high flux retention, excellent separation performance, and excellent operational stability, and can be widely applied in water treatment scenarios such as municipal wastewater treatment.

The invention belongs to the technical field of medical dressings, and discloses a recombinant human collagen combined nano-silver ionic liquid-containing dressing and a preparation method thereof. The invention discloses a liquid dressing. Comprising the following raw materials: 8 to 15 parts of polyvinyl alcohol, 3 to 6 parts of calcium alginate, 1 to 3 parts of polydimethylsiloxane, 0.1 to 0.5 part of an antibacterial agent, 2 to 5 parts of bioactive protein, 1 to 4 parts of sodium hyaluronate, 2 to 5 parts of chitosan, 0.5 to 2 parts of tranexamic acid, 0.3 to 1 part of polypeptide, 0.2 to 0.8 part of an anti-inflammatory agent, 0.5 to 1.5 parts of ethylhexylglycerin, 10 to 20 parts of glycerin, 0.5 to 1.2 parts of carbomer, 0.1 to 0.3 part of biguanide hydrochloride and 40 to 60 parts of deionized water. The comprehensive improvement of the liquid dressing on the aspects of antibiosis, repair promotion, stability and safety is realized. All the components are matched to achieve the effects of broad-spectrum antibacterial property, healing time shortening and activity protection. Temperature gradient control, microwave activation and high-pressure homogenization are adopted in the process, the compatibility of all the raw materials is improved, the dressing is stable in physical performance, free of layering during storage and high in safety, and the requirements for skin wound protection and repair are met.

The invention discloses a hydraulic antibacterial paste material as well as a preparation method and application thereof. The hydrogel antibacterial paste material is obtained by mixing a powder raw material and a liquid raw material which accounts for 30-35 wt% of the mass of the powder raw material, the hydrogel antibacterial paste material comprises the following components in percentage by mass of the powder raw material: 20-40 wt% of a calcium silicate compound, 5-40 wt% of a calcium phosphate compound, 10-40 wt% of a radiation-resistant material and 0.2-0.4 wt% of a macromolecular antibacterial agent, and the macromolecular antibacterial agent is polyhexamethylene biguanide salt. The injectable hydrogel antibacterial paste material can be used for preparing orthopedic or dental filling materials. Compared with the prior art, the antibacterial paste material not only can be self-cured, but also has excellent antibacterial performance, the preparation method is simple and quick, and the antibacterial paste material can be applied to the field of dental or orthopedic repair.

Provided in the present invention are an antimicrobial whitening composition, a white synthetic leather substrate and a preparation method therefor, and an antimicrobial synthetic leather. The antimicrobial whitening composition comprises a cationic antimicrobial agent, an antimicrobial organic substance and a solvent, wherein the cationic antimicrobial agent comprises at least one of a polymeric quaternary ammonium compound, polyethyleneimine, chitosan, a biguanide compound and a polymeric biguanide; and the antimicrobial organic substance comprises at least one of a terpene compound and a derivative thereof, a phenolic compound, an essential oil, an antifungal agent, a preservative and a disinfectant. The man-made leather prepared by means of the antimicrobial whitening composition of the present invention has good performance in terms of both long-lasting antimicrobial properties and maintaining a high whiteness.

The application discloses a kind of organic metal catalyst based on biguanide-based ligand and its preparation method and application, belong to polymer material field.The organic metal catalyst is by the ligand with biguanide-based structure and magnesium salt coordination and form.The preparation method of the application is simple, condition is mild, the obtained organic metal catalyst is with magnesium as metal center, its toxicity is lower, catalytic activity is high, can successfully catalyze cyclic lactone under solvent or solvent-free condition ring-opening polymerization reaction, and product molecular weight is high, distribution is narrow.

The invention discloses a flame-retardant wood-plastic plate and a preparation method thereof, and relates to the technical field of wood-plastic plates. The flame-retardant wood-plastic plate prepared by the invention comprises modified polyethylene and modified wood flour, and the modified polyethylene is obtained by grafting a functional monomer to polyethylene and then reacting with phosphorus pentoxide; the modified wood flour is obtained by wrapping wood flour with polyether amine and then reacting with o-tolyl biguanide, and the prepared flame-retardant wood-plastic plate has good flame-retardant, antibacterial and anti-aging properties.

The invention relates to the technical field of coating preparation, in particular to a preparation method of kerosene-resistant antibacterial static conductive coating. The invention relates to a preparation method of a kerosene-resistant antibacterial static conductive coating. The kerosene-resistant antibacterial static conductive coating comprises a component A raw material and a component B raw material, the component A is prepared from the following raw materials: novolac epoxy resin, toughened modified resin, a reactive diluent, an auxiliary agent, polyhexamethylene biguanide, an anti-rust filler and a solvent; and the component B comprises the following raw materials: a toughening phenolic aldehyde amine curing agent and an alicyclic amine curing agent. The preparation method of the kerosene-resistant antibacterial static conductive coating has the advantages that the phenomena of bubbling and shedding are avoided, the coating has a protection effect and stable salt spray resistance and surface resistivity, and the static conductive requirement is met. The antibacterial rate is increased, the surface pollution is effectively inhibited, the green chemical industry standard is met, the adhesive force of the coating is improved, the wear resistance is improved, and high toughness can be kept in a low-temperature state.

An ophthalmic composition according to the present invention contains (A) 0.01-0.5 w / w% of a copolymer having constituent units represented by formula (1a) to formula (1c), where the molar ratio of each constituent unit is a:b:c=100:10-400:2-50 and the weight average molecular weight is 5,000-2,000,000, (B) 0.000001-0.0001 w / w% of polyhexamethylene biguanide represented by formula (2) or a salt thereof, and (C) 0.02-5.0 w / w% of polyoxyethylene hydrogenated castor oil and / or (D) 0.02-5.0 w / w% of polyoxyethylene glycol monostearate.　According to the present invention, it is possible to provide an ophthalmic composition that exhibits sufficient preservation efficacy and has high lubricity.

Compositions and methods for the treatment of inflammatory skin diseases. The compositions include a pharmaceutically effective amount of polyhexamethylene biguanide (PHMB), polyaminopropyl biguanide (PAPB), and / or chlorhexidine (CHG) in a petrolatum carrier.

The invention relates to the technical field of medicines, in particular to an intelligent response type cervical auxiliary fertility gel which comprises the following components in percentage by mass: 0.1-2% of a gel matrix which is selected from one or more of hydroxypropyl methyl cellulose, hydroxyethyl cellulose, sodium alginate and gellan gum; 0.05%-0.5% of a gel adjusting auxiliary agent which is selected from zinc chloride or calcium lactate; the osmotic pressure regulator is selected from one or more of glycerol, glucose, sodium chloride, mannitol, sorbitol, polyethylene glycol and propylene glycol; 0.1%-2% of an acid-base regulator which is selected from one or more of disodium hydrogen phosphate, sodium dihydrogen phosphate, dipotassium phosphate and potassium dihydrogen phosphate; according to the present invention, the toxicity grade of the gel on cervical cells is less than or equal to grade 2 (ISO 10993-5 standard), the cell survival rate is more than or equal to 70%, and the safety is high.

The present invention relates to a composition comprising, as active ingredients: (1) a biguanide-based compound or a pharmaceutically acceptable salt thereof; (2) 2-deoxy-D-glucose; and (3) inositol hexaphosphate or a pharmaceutically acceptable salt thereof, inositol, or a mixture thereof. The composition according to the present invention exhibits a synergistic anticancer effect by appropriately combining specific drugs having a problem that needs to be used in a large amount, thereby making it possible to kill cancer cells in a small amount and effectively treat the cancer. Furthermore, the composition of the present invention may kill only cancer cells without side effects by exhibiting a specific toxic effect on cancer cells without showing toxicity on normal cells and thus be usefully used as an anticancer agent and for preventing or improving cancer.

This application relates to the technical field of dairy cow pharmaceutical preparations, and specifically discloses a lysostaphin milk protection film preparation and its preparation process. A lysostaphin milk protection film preparation comprises raw materials in the following mass percentages: 0.0001 - 2% of lysostaphin, 0.0001 - 1% of polyhexamethylene biguanide, 5 - 20% of lubricant, 0.5 - 2% of film-forming agent, 1 - 3% of thickening agent, 1 - 3% of moisturizing agent, 0.1 - 0.5% of vitamin B group, and the balance being purified water; the film-forming agent is a mixture composed of sodium carboxymethyl cellulose and plant polysaccharide in a mass ratio of 1:(2.3 - 4.1). The milk protection film preparation obtained by this application has excellent antibacterial and bactericidal effects, is mild in nature, non-irritating to the skin, and has good repair and nursing effects at the same time.

The invention belongs to the technical field of medical materials, and discloses antibacterial silica gel as well as a preparation method and application thereof. The antibacterial silica gel comprises a silica gel substrate and a copolymer coating on the surface of the silica gel substrate, the copolymer coating is grafted with polyhexamethylene guanidine biguanide; and the copolymer coating comprises an isooctyl acrylate structure and a maleic anhydride structure. The antibacterial silica gel provided by the invention has good antibacterial performance, and further has high tensile strength and tear strength.

The invention relates to the technical field of preparation of polyhexamethylene biguanide, in particular to a synthesis method of polyhexamethylene biguanide, which comprises the following steps: S1, dissolving 1, 6-hexamethylenediamine hydrochloride in a solvent, and adjusting the pH value to weak acidity; s2, adding 1, 6-bis-cyano guanidino hexane into S1, carrying out prepolymerization, and then heating to remove the solvent; s3, carrying out heat preservation treatment on the reaction system in S2, then adding a solvent, and carrying out stirring treatment; and S4, heating the reaction system in S3 to remove the solvent, thereby obtaining the polyhexamethylene biguanide. According to the method provided by the invention, the solvent is evaporated out after prepolymerization, the reaction system is in a molten resin shape, and the polymerization degrees are different due to the fact that no solvent exists and all parts are heated unevenly, so that the polymer can be dispersed evenly again and then react continuously in the mode, and the polymer with uniform molecular weight distribution is obtained.