1409 results about "Electrostatic interaction" patented technology

A biodegradable, mixed polymeric micelle used to deliver a selected nucleic acid into a targeted host cell contains an amphiphilic polyester-polycation copolymer and an amphiphilic polyester-sugar copolymer. The polyester-polycation copolymer forms an electrostatic interaction with polyanionic nucleic acids, and the polyester-sugar copolymer directs the micelle-nucleic acid complex to cells in vivo. Additional copolymers with similar properties may also be included. The composition improves delivery efficiency by providing a particulate gene carrier for which particle size and charge density are easily controlled by multivariate means. Various kinds of ligands and other functional compounds may be also be introduced using the composition. The composition may be used in a method for transforming a targeted host cell with a selected nucleic acid.

Compositions, systems and related methods for delivering a supercharged protein or a complex of a supercharged protein and therapeutic agent (e g, nucleic acid, peptide, small molecule) to cells are disclosed. Superpositively charged proteins may be associated with nucleic acids (which typically have a net negative charge) via electrostatic interactions. The systems and methods may involve altering the primary sequence of a protein in order to “supercharge” the protein (e g, to generate a superpositively-charged protein). The compositions may be used to treat proliferative diseases, infectious diseases, cardiovascular diseases, inborn errors in metabolism, genetic diseases, etc.

An electrostatic interaction system includes a first structure having a first fixed electrostatic charge and a second structure having a second fixed electrostatic charge. The polarity of the first and second fixed electrostatic charges determines a positional relationship of the first structure to the second structure.

The invention relates to a preparation method of a nano particle carbon nanotube compound catalyst. The carbon nanotube with electric charges on surface is obtained from the materials which can generate non-covalent action with the carbon nanotube. Then nano particle with opposite electric charges on surface to that of the non-covalent modified carbon nanotube is added and completely mixed, and excess nano particle is removed to finally obtain the nano particle carbon nanotube catalyst compound. A plurality of nano particle carbon nanotube catalyst compounds can be prepared by the invention, all of which represent very good catalytic activities. The invention adopts the method of non-covalent modified carbon nanotube to obtain carbon nanotube with perfect surface. Meanwhile, the invention provides the nano particle, in particular, the morphology controllable nano particle on the load of carbon nanotube with an effective way by utilizing the electrostatic interaction of carbon nanotube and namo particle, thus extending the applications of morphology controllable nano particle in catalytic field.

The invention discloses a preparation method of a cobalt electro-catalysis oxygen reduction material wrapping a nitrogen-doped carbon nanotube. The method includes the following steps of making melamine, cobalt nitrate hexahydrate and glucose react to obtain a self-assembled melamine precursor, and baking the self-assembled melamine precursor to obtain a cobalt nanoparticle hybrid material electro-catalysis oxygen reduction agent wrapping the nitrogen-doped carbon nanotube. In preparation of the precursor, a self-assembled body can be formed through the electrostatic interaction and the hydrogen-bond interaction by means of nitrate radicals and melamine under the acid condition, cobalt ions are adsorbed into the self-assembled body, ordered arrangement and assembly of materials in the high-temperature baking process are facilitated by the pre-assembled precursor, and therefore more catalysis active sites are exposed, and the improvement of the performance of a catalyst is facilitated.

The invention provides a pharmaceutical composition that can be used for efficient administration of low-molecular weight drugs and polymeric compounds such as peptides and proteins by methods other than injection, as well as a method for producing the composition. The pharmaceutical composition is for transmucosal administration and comprises (a) a drug having a positive or negative charge at a predetermined pH, (b) a pharmaceutically acceptable small particle and (c) a pharmaceutically acceptable surface-coating polymer capable of being electrically charged at the pH, wherein the surface of the small particle is coated by the surface-coating polymer, the drug is immobilized on the surface of the small particle via the surface-coating polymer, and a complex is formed by a noncovalent interaction between the small particle and the surface-coating polymer and a concurrent electrostatic interaction between the surface-coating polymer and the drug.

According to one aspect, the disclosure is directed to an example embodiment in which a circuit-based arrangement includes a circuit-based substrate securing a channel, with an effective width that is not limited by the Debye screening length, along a surface of the substrate. A pair of reservoirs are included in or on the substrate and configured for containing and presenting a sample having bio-molecules for delivery in the channel. A pair of electrodes electrically couple a charge in the sample to enhance ionic current flow therein (e.g., to overcome the electrolyte screening), and a sense electrode is located along the channel for sensing a characteristic of the biological sample by using the electrostatic interaction between the enhanced ionic current flow of the sample and the sense electrode. Actual detection occurs by using a charge-signal processing circuit to process the sensed charge signal and, therefrom, provide an output indicative of a signature for the bio-molecules delivered in the channel.

The invention relates to a novel liver target drug carrier-glycyrrhetinic acid-polyethylene glycol/chitosan or chitosan derivative liver target compound drug delivery system. During the preparation of the nano-drug delivery system, the liver target small-molecule glycyrrhetinic acid is firstly used for modifying amino polyethylene glycol by the different sites, then a water soluble big-molecule liver target compound is prepared and is mixed with a solution containing chitosan or chitosan derivative by a certain proportion, an ion cross-linking agent is added under the stirring condition, and a target group is introduced at the same time of the spontaneous formation of nanoparticles by physical winding and electrostatic interaction. The method of introducing the target group of the invention is novel, the formation of spheres is simple, the conditions are moderate, and the content of the target group is high (the weight percentage of glycyrrhetinic acid is 5 to 30 percent). The drug delivery system has strong killing capacity to the cancer cells, the in vitro experiments show that the drug delivery system has very strong binding capacity with the liver cells, and the high content of the target group can improve the liver target capacity of the drug delivery system, realize the target positioning of the liver and open a new way for the treatment of liver cancer.

Surface-molecularly imprinted sensors were fabricated for detecting ionic molecules. Target molecules are recognized by the combination of a hydrophobic interaction with the imprinted polymer layer to provide specificity and an electrostatic interaction to provide sensitivity Coupling surface imprinting techniques with an electrochemical detection method, such as potentiometry, allows specific recognition of target molecules and translation of the recognition event into an output signal by the sensor.

Particles of cathodic materials are coated with polymer to prevent direct contact between the particles and the surrounding electrolyte. The polymers are held in place either by a) growing the polymers from initiators covalently bound to the particle, b) attachment of the already-formed polymers by covalently linking to functional groups attached to the particle, or c) electrostatic interactions resulting from incorporation of cationic or anionic groups in the polymer chain. Carbon or ceramic coatings may first be formed on the surfaces of the particles before the particles are coated with polymer. The polymer coating is both electronically and ionically conductive.

The invention belongs to the field of absorbing material research, and particularly relates to a method for preparing stealthy fabric with double functions of radar stealth and infrared stealth. According to the method, the binding strength of a radar stealth layer and textile is improved by using electrostatic interaction between plasma grafting-introduced carboxyl and polyaniline absorbing materials and the surface etching effect of low-temperature plasma; the binding strength of the radar and the infrared stealth layers and the textile is improved by using the reactivity between a binary aldehyde crosslinking agent and amino on a polyaniline polymer and a microcapsule wall material and a polyurethane adhesive; the obtained stealth coating is not only good in binding strength with the textile, but also light in quality and good in durability, and has multi-band stealth effects of radar, infrared light and visible light.

The invention relates to a method for connecting nanoparticles and polymer spheres with chemical bonding in the polymer microspheres and its preparation and biomedical applications, which recombines the water-soluble inorganic nano-particles into hydrophobic polymers with reactive surfactant through emulsion polymerization. In this way, the multi-functional polymer microspheres can be obtained through the recombination of different types of nanoparticles on the same microspheres. The positive charge on the microsphere surface can couple the biological molecules onto it by the electrostatic interaction to get a microsphere fluorescent probe used in immunodetection, chromosome analysis of multiple genes, protein array, DNA sequencing and simultaneous detection in different regions of gene chips and cell or biological tissues.

Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.

The invention provides an antibacterial hydrogel composite material and a preparation method thereof. The antibacterial trauma repair material is hydrogel formed by chitosan and gamma-polyglutamic acid according to a mass ratio of 1/0.5-2 through electrostatic interaction, and nano silver is synthesized and loaded in situ on the hydrogel by taking PVP as a dispersant. the preparation method is simple, convenient and quick, and the trauma repair material is high in practicability. The composite hydrogel trauma repair material integrates bactericidal and immune activity, high biocompatibility and hemostatic activity that chitosan has, high water absorbency that gamma-polyglutamic and broad-spectrum antibacterial property and freeness of drug resistance that nano silver has, and composite hydrogel nano silver is small in grain diameter, uniform in distribution and less prone to aggregation, thereby having high antibacterial performance; when the material is used for wound dressing, wound infection can be avoided effectively, and wound healing can be accelerated.

The invention relates to the field of MOF-precious metal nanocomposites, and particularly relates to an MOF-precious metal composite SERS substrate and a preparing method thereof. In an alcohol solution, CTAB modified positive-charged precious metal nanoparticles are loaded onto the surface of an MOF material through electrostatic functions to form the MOF-precious metal composite SERS substrate. Compared with in-situ growth methods, the precious metal nanoparticles are loaded onto the surface of the MOF material through electrostatic functions in the method, a high porosity, a high specific surface area and excellent adsorption capability of the MOF material are maintained, morphology, the size and density of the metal nanoparticles on the surface of the MOF can be accurately controlled, and a large amount of Raman active sites are prepared, thus further effectively improving properties of the composite substrate SERS. The MOF-AuNPs composite SERS substrate prepared by the method has double functions including adsorption enrichment and Raman enhancement, does not need surface modification and can achieve direct and highly sensitive detection of molecules such as fluoranthene.

The invention discloses a preparation method of a two-dimensional inorganic layered compound/graphene composite material. The preparation method of the composite material comprises the following steps: preparing layered compound dispersion liquid with positive charges on the surface and oxidized graphene dispersion liquid with negative charges; mixing the two kinds of solution to perform self-assembling under an electrostatic interaction to obtain the ordered two-dimensional inorganic layered compound/graphene composite material assembled alternatively layer by layer; and carrying out reduction reaction on the composite material under certain conditions to obtain the two-dimensional inorganic layered compound/graphene composite material. According to the two-dimensional inorganic layered compound/graphene composite material, the two-dimensional inorganic layered compound and the graphene are assembled alternatively layer by layer under the electrostatic interaction; the required equipment has low requirement and is easy to operate; the graphene can provide a good electronic transmission channel for the inorganic layered material, so as to enhance the electrical conductivity of the inorganic layered material, prevent agglomeration, and achieve an important effect on the material structure stability. The two-dimensional inorganic layered compound/graphene composite material can be widely applied to the fields of catalytic and electrochemical energy storage fields.

The invention relates to a method for preparing an anti-pollution polysulfone porous membrane by self-assembling immobilization of metal ions. According to surface electrical load properties of a membrane prepared from a polysulfone material, an amino-containing compound with high positive charge density and hydrophily is used as a modification material, the modification material is adsorbed by the surface of the polysulfone porous membrane under electrostatic interaction, through a large amount of amino groups of the modification material, the modification material and Cu<2+>, Zn<2+> or Ag<+> of an inorganic antibacterial agent undergo a coordinated complexation reaction, and the inorganic antibacterial agent is immobilized on the modification material molecule by complexation action so that the polysulfone porous membrane with good hydrophily and antibacterial activity is obtained. The prepared polysulfone porous membrane has hydrophily, antibacterial property and pollution resistance. The method has simple processes, does not need complex equipment and is suitable for industrial scale application. The porous membrane can be widely used in water treatment in the field of environment, chemical engineering, foods and medicine.

The invention discloses a preparation method of a double-emission carbon-based nano probe prepared based on an electrostatic interaction induced self-assembling method and application of a product ofthe preparation method to in-vivo and in-vitro temperature detection of organisms, and belongs to the technical field of colorimetric fluorescence detection. The preparation method comprises synthesisof blue fluorescence carbon dots (B-CDs) which have no temperature sensitivity and negative charges on surfaces, preparation of red fluorescence carbon dots (R-CDs) which have temperature sensitivityand positive charges on surfaces and preparation of the double-emission carbon-based nano probe. According to the double-emission carbon-based nano probe obtained by the preparation method, the double-emission carbon-based nano probe has different responsiveness aiming at different temperature and has different compound temperature color changes; the double-fluorescence emission nano probe can beused for colorimetrically detecting in-vivo and in-vitro temperature of the organisms by naked eyes, and has high sensitivity (0.93 percent/DEG C) and operation repeatability, so that the double-fluorescence emission nano probe provides convenience for biological imaging, temperature sensing, environment monitoring, food safety and the like.

The invention pertains to the technical field of polymer materials and particularly relates to a waterborne resin emulsion for car cleaning cloth or common cleaning cloth and a textile finishing adhesive agent, a synthetic method and application of the waterborne resin emulsion. The resin emulsion consists of a waterborne resin polymer, an emulsifier, an evocating agent, a pH value modulator and water; the waterborne resin polymer is obtained by polymerization of 3-5 monomers such as butyl acrylate, ethyl hexyl acrylate and methyl methacrylate and the like. The synthesis comprises two steps of monomer pre-emulsion and polymerization by the evocating agent. The product of the invention has stable performance and good film formation performance, as well as soft hand feeling, good moisture permeability, long-term moisture and environment protection by absorbing fine dusts when used as cleaning cloth, and when used as a textile adhesive agent, the product can not only realize the characteristics and requirements above, but also decrease electrostatic interaction of the textile, thus having good and wide application in the textile field.

Polyamines having the formula:or a salt thereof with a pharmaceutically acceptable acid wherein: R1-R6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally having an alkyl chain interrupted by at least one etheric oxygen atom, or hydrogen;N1, N2, N3 and N4 are nitrogen atoms capable of protonation at physiological pH's;a and b may be the same or different and are integers from 1 to 4;A, B and C may be the same or different and are bridging groups which effectively maintain the distance between the nitrogen atoms such that the polyamines:(i) are capable of uptake by a target cell upon administration thereof to a human or non-human animal; and(ii) upon uptake by the target cell, competitively bind via an electrostatic interaction between the positively charged nitrogen atoms to substantially the same biological counter-anions as the intracellular natural polyamines in the target cell;the polyamines, upon binding to the biological counter-anion in the cell, function in a manner biologically different than the intracellular polyamines, the polyamines not occurring in nature; as well as pharmaceutical compositions embodying the polyamines and methods of treating patients requiring anti-neoplastic therapy.

Embodiments of the present invention provide a high voltage lithium cobaltate positive cathode material, including a lithium cobaltate substituted and doped at lithium positions. The lithium cobaltatesubstituted and doped at lithium positions has a general formula of Li1-xMaxCoO2, where x is greater than 0 and less than or equal to 0.05, Ma is a doping element, Ma is selected from one or more ofelements having an ionic radius ranging from 68 pm to 90 pm and an ion valence state greater than or equal to 1. The high-voltage lithium cobaltate positive electrode material is formed by substituting and doping lithium cobaltate at lithium positions, and the electrostatic interaction and cobalt dissolution of lithium cobaltate caused by lithium de-intercalation at a high voltage is alleviated, so that the structure and cycle stability of the material is improved, and the material has a high capacity and good cycle stability at the high voltage. Embodiments of the present invention further provide a high-voltage lithium cobaltate positive electrode material preparation method and a lithium ion battery.