1050 results about "Electrostatic interaction" patented technology

The invention provides a preparation method of an electrochemical biosensor based on a PLL-coated VPAu modified nuclear track membrane, and belongs to the field of electrochemical biosensing analysis. The electrochemical biosensor for detecting troponin is constructed by adsorbing a PLL (at) VPAu composite nanomaterial synthesized by an ultrasonic liquid phase assisted method into a nuclear track membrane pore channel through electrostatic interaction and connecting a specific recognition molecule of a target to the surface of the pore channel modified by the PLL (at) VPAu by utilizing a bonding reaction mechanism. After a target object is captured by the recognition molecules connected to the nuclear track membrane, the effective aperture of the nuclear track membrane nanopores is reduced, and the electrochemical workstation can convert the biological behavior into an electric signal, so that high-sensitivity and rapid detection of the target protein is realized. The method has very important theoretical and practical significance in the field of medical diagnosis, and a new direction is provided for application of the nuclear track membrane in the field of analysis and detection.

The invention discloses a high-biocompatibility pH response type Pickering emulsion and a preparation method thereof, and relates to the technical field of food and materials. An interfacial film with high mechanical strength is constructed by adopting electrostatic interaction and hydrophilic-hydrophobic complementary characteristics between the hydrophobic shellac nanoparticles carrying negative charges and the hydrophilic cationic colloidal particles carrying positive charges, and the prepared emulsion has good viscoelasticity and stability. In addition, due to the unique solubility of the shellac nanoparticles, the Pickering emulsion prepared by the preparation method disclosed by the invention has excellent pH responsiveness. The preparation method of the Pickering emulsion is convenient and simple, the stabilizer is wide in source and low in price, the biocompatibility of the emulsion is high, and the Pickering emulsion has wide application prospects in the aspects of food, medicine, materials and the like.

The invention relates to the technical field of petrochemical engineering, and discloses a temperature-resistant anti-swelling agent for fracturing and a preparation process thereof.The preparation method comprises the steps that glycerol triglycidyl ether and diethanol amine are subjected to a ring-opening reaction, a polyhydroxy tertiary amine monomer is obtained, then the polyhydroxy tertiary amine monomer and chloromethylated polystyrene are subjected to a quaternization reaction, and the temperature-resistant anti-swelling agent for fracturing is obtained. Quaternary ammonium salt groups of the anti-swelling agent and negative charges on the surface of clay form electrostatic interaction, and hydroxyl groups and the surface of the clay form hydrogen-bond interaction, so that the anti-swelling agent can be firmly adsorbed on the surface of the clay to form a layer of polymer film, the clay is prevented from being in contact with water, the phenomenon that the clay swells when encountering water is effectively inhibited, and the anti-swelling rate is very high. And the anti-swelling agent contains a heat-resistant polystyrene molecular chain, has excellent high temperature resistance, can maintain good structural stability at high temperature, still maintains high anti-swelling rate, and is suitable for a fracturing fluid system for high-temperature oil reservoir exploitation.

The invention provides a gamma-polyglutamic acid electrostatic compound. The gamma-polyglutamic acid electrostatic compound is formed by compounding gamma-polyglutamic acid and an antibacterial surfactant with positive charges. Compared with the prior art, the gamma-polyglutamic acid electrostatic compound provided by the invention is constructed through electrostatic interaction, not only has good cell compatibility and blood compatibility, but also has excellent broad-spectrum antibacterial property, can be uniformly coated on the surfaces of medical instruments with different base materials, shapes and sizes, is stable in combination, and can be applied to medical instruments with different shapes and sizes. The coating process has universality and is suitable for solving the problem of pollution of current medical instruments, prolonging the service life of the medical instruments and solving the problem of coating stability of the surfaces of inner and outer cavities of complex instruments.

The invention discloses a method and device for predicting protein-ligand binding affinity based on distance and atomic contact number, comprising: acquiring a data set of protein-ligand binding affinity, the data set comprising: atomic information of a protein receptor and atomic information of a ligand; classifying atoms of a protein-ligand compound in the data set according to a preset atom type, and calculating a distance and an atom contact number of an atom pair of a protein-ligand in the data set according to the atom type; training a preset model by taking the protein-ligand distance and the atom contact number as training data to obtain a protein-ligand binding affinity prediction model; and obtaining to-be-predicted protein-ligand data information, inputting the to-be-predicted protein-ligand data information into the protein-ligand binding affinity prediction model, and outputting the to-be-predicted protein-ligand binding affinity. The method is not limited to the power exponent of the distance in the traditional electrostatic interaction energy and Van der Waals interaction energy, and the prediction capability of the affinity is improved.

Disclosed is a microscopic comparison and experimental verification method for the wettability of similar surfactants on coal dust, comprising: collecting a coal sample on site from a mining area and analyzing the coal sample by infrared spectroscopy and nuclear magnetic resonance spectroscopy to obtain information on functional groups and carbon structure of coal molecules; S2: constructing a surfactant-coal molecule electrostatic interaction model and analyzing an orbital energy difference and an electrostatic potential difference between surfactant molecules and coal molecules, etc. S6. The invention provides a simple and effective idea for the selection of surfactants.

The invention relates to a preparation method of an antibacterial film. The preparation method comprises the following steps: preparing and forming an m-SiO2-SH-Ag-HA composite material; and blending the m-SiO2-SH-Ag-HA composite material into a membrane material, so as to form the antibacterial membrane. The hydrophilic HA in the antibacterial film formed by the preparation method can coat the outer side of m-SiO2-SH-Ag through electrostatic interaction to form an electrostatic barrier, effectively prevent the release of Ag < + > and play roles in stabilization, protection and slow release on one hand, and can increase the hydrophilicity of the surface of the film and effectively inhibit the early adhesion of bacteria on the other hand. When the target bacteria appear, HA coated on the surface of the m-SiO2-SH-Ag-HA is degraded by secreting hyaluronidase, so that the exposure and release of Ag < + > are promoted. The antibacterial film disclosed by the invention can release sterilization components through enzymatic initiation to realize on-demand antibiosis, and toxic and side effects and resource waste caused by uncontrollable continuous release of Ag < + > to the environment are avoided.

The invention belongs to the technical field of biomedical materials, and discloses injectable heterogeneous cascade nano-enzyme antibacterial hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: in a process of preparing cerium dioxide nano-enzyme by a reverse micelle method, introducing molybdenum disulfide nano-particles with a nano flower-shaped structure so as to deposit the cerium dioxide nano-enzyme on the surfaces of the molybdenum disulfide nano-particles in situ to obtain nano-composite particles; through electrostatic interaction, glucose oxidase is loaded on the surfaces of the nano composite particles to form a heterogeneous cascade nano enzyme material; the preparation method comprises the following steps: uniformly mixing sodium alginate and hyaluronic acid in water, and sequentially adding an NO donor, a heterogeneous cascade nano-enzyme material and a cross-linking agent to obtain the injectable heterogeneous cascade nano-enzyme antibacterial hydrogel. The preparation method is simple, and the injectable heterogeneous cascade nano-enzyme antibacterial hydrogel has a strong antibacterial effect and can be used for preparing the antibacterial hydrogel. Particularly, the compound has a remarkable killing effect on gram-negative bacteria and gram-positive bacteria.

The invention relates to the field of non-woven fabrics, in particular to a medical antibacterial non-woven fabric and a preparation method thereof.The medical antibacterial non-woven fabric is characterized in that an SMS non-woven fabric is soaked in a composite finishing liquid, after-finishing is conducted through a two-soaking and two-rolling process, and the problem that dust, germs and other fine substances in air are adsorbed due to the electrostatic interaction caused by poor moisture absorption performance of existing non-woven fabrics is solved; in addition, the hydrogel has good biocompatibility and antibacterial performance; the composite finishing liquid is prepared from the following raw materials in parts by weight: 15 to 18 parts of dimethylol dihydroxy ethylene urea resin, 3 to 4 parts of composite microspheres, 6 to 8 parts of composite cellulose, 2.5 to 3 parts of magnesium chloride, 0.2 to 0.5 part of fatty alcohol-polyoxyethylene ether and 100 parts of water.

The invention relates to a core-shell structure drug-loaded magnetic-thermal hydrogel microsphere for treating drug-resistant ovarian cancer and a preparation method thereof, belonging to the field of biological and medical micro-nano materials and technologies, and the core-shell structure drug-loaded magnetic-thermal hydrogel microsphere is formed by combining an inner core and a shell layer through covalent crosslinking and electrostatic interaction. An anti-tumor drug cis-platinum and magnetic nanoparticles are loaded on an inner core, and an AZ191 inhibitor is loaded on a chitosan shell, so that preferential release of AZ191 is realized to inhibit a drug-resistant signal channel and reduce the drug resistance of cancer cells, and the cis-platinum is slowly released after the action is completed to kill tumor cells. And the magnetic nanoparticles in the inner core can be heated under an external magnetic field, so that multifunctional synergistic treatment of magnetic hyperthermia, drug resistance inhibition and chemotherapy is realized. Chitosan and sodium alginate are biodegradable materials, so that the utilization rate of the embedded medicine can be increased, and meanwhile, the medicine can be metabolized out of a body. The preparation method does not relate to toxic cross-linking agents and organic solvents, and the prepared hydrogel core-shell microspheres have no biotoxicity. Complicated operation steps are not needed, the technological process is simple, the preparation period is short, and the application range is wide.

The invention discloses an amino-functionalized MOFs (Metal-Organic Frameworks) composite heat stabilizer as well as a preparation method and application thereof, and belongs to the technical field of high polymer materials. The amino-functionalized MOFs composite heat stabilizer is prepared from the following components in parts by weight: 100 parts of amino-functionalized protonated MOFs, 20 to 30 parts of zinc stearate and 10 to 15 parts of polyol. According to the amino-functionalized MOFs stabilizer provided by the invention, HCl generated in a PVC (Polyvinyl Chloride) processing process is adsorbed by utilizing the characteristics of large specific surface and multiple structural pores of MOFs, and-NH3 + and HCl form a hydrogen bond or are subjected to electrostatic interaction or are subjected to an ion exchange reaction to generate-NH3Cl; the inner surfaces of pore channels of the protonated MOFs are provided with positive charges or acidic groups, so that polar molecules HCl can be better and selectively adsorbed; zinc stearate reacts with HCl and is subjected to a cross-linking reaction with PVC, so that the degradation effect of HCl on PVC is inhibited; znCl2 generated in the reaction process of zinc stearate and hydrogen chloride is complexed with polyhydric alcohol, and the thermal stability of PVC is improved through the combined action of the three.

The invention relates to the technical field of heavy metal recovery, in particular to a method for recovering heavy metal from metal waste. Comprising the following steps: preparing silicon-tungsten composite acid salt; preparing heteropolyacid powder; preparing a resin heteropolyacid composite material; heavy metals are recovered from metal wastes by a resin adsorption method. The silicon-tungsten composite acid salt is prepared under mild conditions through reaction of sodium metasilicate, sodium tungstate and potassium chloride, the operation is simple, the conditions are easy to control, the silicon-tungsten composite acid salt has rich active sites and a large specific surface area, the surface of the silicon-tungsten composite acid salt carries negative charges, and the surface of the silicon-tungsten composite acid salt is not prone to damage. Compared with a traditional chemical precipitation method, the method for extracting the heavy metal by using the silicon-tungsten composite acid salt does not need to add a large number of chemical reagents, and secondary pollution is reduced.

The invention belongs to the technical field of wearable equipment, and particularly relates to a hydrated salt phase change gel material, a preparation method thereof, wearable equipment and a preparation method thereof. The hydrated salt phase change gel material provided by the invention is prepared from the following raw materials in percentage by mass: 30 to 97.7 percent of hydrated salt, 1 to 40 percent of gel monomer, 0 to 20 percent of conductive and heat-conducting filler, 0.1 to 5 percent of cross-linking agent, 0.1 to 5 percent of initiator, 0 to 40 percent of high polymer material, 0 to 10 percent of nucleating agent, 0.05 to 2.5 percent of additive and 0 to 40 percent of water. A gel network in the hydrated salt phase change gel material has a large number of hydrophilic groups, hydrated salt is adsorbed through hydrogen bonds and electrostatic interaction, leakage of the hydrated salt can be prevented, it can be guaranteed that the hydrated salt is evenly distributed in the gel network, phase separation is avoided, and use safety is improved.

The invention relates to the technical field of pigments, and particularly discloses a water-based colored aluminum-based pigment and a preparation method thereof. The water-based colored aluminum-based pigment comprises aluminum powder, the surface of the aluminum powder is coated with a silicon dioxide layer, and the surface of the silicon dioxide layer is grafted with amino silanol; the preparation method comprises the following steps: stirring and mixing aluminum powder and absolute ethyl alcohol to obtain an aluminum powder dispersed phase; adding the aluminum powder dispersed phase into the silica sol, then adding ammonia water, and stirring for reaction to obtain aluminum powder coated with a silicon dioxide layer; and adding amino silanol into the aluminum powder coated with the silicon dioxide layer, and carrying out condensation reaction to obtain the water-based colored aluminum-based pigment. According to the water-based colored aluminum-based pigment, the silicon dioxide layer is adopted to reduce corrosion of water to the aluminum powder, the amino silanol and the anionic dye are adopted to generate electrostatic interaction force, and different anionic dyes can be compounded, so that the obtained water-based colored aluminum-based pigment has the advantages of being rich in color, high in stability and good in dispersity in a water-based system.

The invention relates to a regenerated cellulose-based composite metal organic framework diaphragm as well as a preparation method and application thereof. The diaphragm comprises: a substrate, which is made of regenerated cellulose; the surface of the regenerated cellulose is connected with a sulfonic acid group; the sulfonic acid group establishes a 3D sulfonic acid group network on the surface of the regenerated cellulose; the metal organic framework is arranged on the surface of the substrate; the metal organic framework and the regenerated cellulose can be connected at least through electrostatic interaction and coordination bond interaction. The technical problem to be solved is how to provide a composite diaphragm formed by tightly and stably combining regenerated fibers and a metal organic framework, so that the prepared diaphragm is good in mechanical property and electrochemical property.

The invention discloses a nano-carrier based on charge crosslinking, a preparation method of the nano-carrier and application of the nano-carrier as a tumor chemotherapy drug. Wherein the nano-carrier is formed by assembling two polymer chains with positive and negative charges through electrostatic interaction, a precursor ligand on a polymer chain B releases an organic ligand under exogenous or endogenous stimulation, and competes for metal ions on a polymer chain A with positive charges to generate a metal complex in situ, and meanwhile, the electrostatic interaction of the nano-carrier is weakened, so that the metal complex is formed. The dissociation of the nano-carrier is caused, a macromolecular chain B containing an organic ligand is released, and the effect of tumor chemotherapy or immunoregulation is achieved. The method is simple to operate, short in time consumption and mild in reaction condition; the material is good in biocompatibility and high in safety degree. Pharmacodynamic experiments in some embodiments show that the nano-carrier can effectively kill the breast cancer and trigger cellular immunogenic death, meanwhile, tumor cell metastasis is inhibited, and a new thought and means are provided for the clinical problem of breast cancer lung metastasis urgently needing to be solved at present.

The invention provides carbon-based material reinforced interpenetrating network conductive hydrogel as well as preparation and application thereof, and belongs to the field of flexible electronics and sensing materials. The method comprises the following steps: (1) preparing a carbon-based material organic dispersion liquid; and (2) preparing the interpenetrating network conductive hydrogel. The prepared interpenetrating network conductive hydrogel is composed of an SF network and a hydrophobicity-associated PAM network, a carbon-based material organic dispersion liquid is added into the SF network and the hydrophobicity-associated PAM network, so that the carbon-based material is uniformly dispersed in the gel network, the carbon-based material is easily mutually pulled with an SF molecular chain and a PAM molecular chain in the gel network to form electrostatic interaction and hydrogen bonds, and the conductivity of the hydrogel is improved. Meanwhile, the PAM molecular chain, the SF molecular chain and the carbon-based material have rich hydrophilic groups, so that a plurality of dynamic hydrogen bonds can be formed, and the interface interaction between the conductive material and a polymer matrix is greatly improved; the interpenetrating network conductive hydrogel prepared by the invention is used as a response thixotropic sensor and has excellent sensing performance.

The invention discloses a novel long-acting bird repellent and a preparation method thereof, and belongs to the technical field of chemical bird repelling. The bird repellent is composed of a core material and a wall material, the core material is a mixture of geraniol, cinnamyl aldehyde and allicin according to the mass ratio of 1: (1.2-1.5): (0.5-0.8), the wall material is modified beta-cyclodextrin and pumpkin seed protein nanoparticles, and the mass ratio of the geraniol, the cinnamyl aldehyde and the allicin is (5-7): (3-5): (1-3). The preparation method comprises the following steps: preparing the quaternary ammonium salt modified beta-cyclodextrin, including the core material, performing high-speed shearing emulsification on the quaternary ammonium salt modified beta-cyclodextrin and the pumpkin seed protein nano dispersion liquid, and performing freeze drying to obtain a final product. According to the invention, a stable and compact'molecular inclusion + physical barrier 'dual slow-release structure is constructed by utilizing the electrostatic interaction between the positively charged modified beta-cyclodextrin and the negatively charged protein nanoparticles, the release time of effective components is remarkably prolonged to 9 months or more, and the composite material has excellent rain wash resistance and ultraviolet resistance, and can be used for preparing a composite material with a good application prospect. And efficient, environment-friendly and long-acting bird repelling is realized.

The invention discloses an oral monoclonal antibody micro-coated nanopolysaccharide microsphere preparation for targeted therapy of inflammatory bowel diseases and a preparation method thereof. According to the method, oxidized mannan and an anti-TNF-alpha monoclonal antibody are mixed and cross-linked by a cross-linking agent containing a diselenide bond to form the drug-loaded nanoparticles. Mixing the drug-loaded nanoparticles with pectin, dropwise adding the mixture into a calcium chloride solution through an electrostatic spinning device, and carrying out ionic crosslinking to obtain the oral monoclonal antibody micro-coated nano polysaccharide microsphere preparation with the particle size range of 180-200 microns. The drug-loaded polysaccharide microsphere delivers the wrapped drug-loaded nanoparticles to a colitis disease part through electrostatic interaction. The drug-loaded nanoparticles are targeted to macrophages, release of the monoclonal antibody is accelerated under the triggering of high-concentration active oxygen at an inflammation part, and the oral stability and the treatment effect of the monoclonal antibody drug are improved. The polysaccharide is used as a monoclonal antibody targeted delivery carrier, raw materials are cheap and easy to obtain, the preparation process is simple and convenient, reaction conditions are mild, and application and development are easy.

The invention provides a modified graphite negative electrode material and a preparation method and application thereof.The preparation method comprises the steps that sulfonated graphene and aminated carbon nanotubes are dispersed in water, and sulfonic acid groups on the surface of the sulfonated graphene and amino groups in the aminated carbon nanotubes are subjected to electrostatic interaction to be self-assembled and combined together; the preparation method comprises the following steps: preparing sulfonated graphene / carbon nano-tubes from sulfonated graphene and carbon nano-tubes to obtain a three-dimensional network compound with high elasticity and high rigidity characteristics, coating the surface of graphite with the three-dimensional network compound to obtain sulfonated graphene / carbon nano-tube-coated graphite, sequentially kneading the sulfonated graphene / carbon nano-tube-coated graphite with asphalt, and fusing with an inorganic nano-material to obtain the sulfonated graphene / carbon nano-tube-coated graphite composite material. And then carrying out carbonization treatment to form the modified graphite negative electrode material which takes sulfonated graphene / carbon nanotubes as an inner shell, takes amorphous carbon and an inorganic nano-material as an outer shell and takes graphite as a core. The modified graphite negative electrode material can give consideration to high rate performance, high energy density and high initial coulombic efficiency at the same time.

The invention provides a medicine composition containing vinloxacin hydrochloride. The medicine composition comprises a quick-release pellet and a sustained-release pellet. The pharmaceutical composition provided by the invention has the advantages of good stability, capability of simultaneously meeting the specific requirement on in-vitro dissolution of the viloxin hydrochloride, small variety and dosage of auxiliary materials, higher safety and suitability for preparation of a preparation. And the protective layer is sprayed on the outer surface of the sustained-release layer, so that the advantages of weakening the electrostatic interaction of the pellets and preventing the particles from caking in the aging process are further achieved. In addition, the invention also provides a preparation method of the pharmaceutical composition, and the method has the advantages of high drug application rate, less fine powder, no filter bag and spray gun head blockage phenomenon, and suitableness for industrial production and application.

The invention belongs to the technical field of adsorbents, and provides a boron nitride-based material and a preparation method and application thereof.The method comprises the following steps that boric acid, melamine and water are mixed and then added into a metal salt solution, and a precursor is obtained; and pyrolyzing the precursor in a protective atmosphere to obtain the boron nitride-based material. The porous boron nitride fiber material loaded with the alkaline metal ions is prepared through a pyrolysis method, and the porous boron nitride fiber material is rich in structural defects, low in density, excellent in chemical inertness, high in oxidation resistance and free of toxicity, so that the porous boron nitride fiber material is suitable for being used as a carrier of the metal ions; therefore, the carbon dioxide adsorption capacity of the pure boron nitride material is further improved. According to the boron nitride material loaded with the alkaline metal ions, the electrostatic interaction and adsorption energy of the boron nitride material to carbon dioxide are enhanced, so that the adsorption of the boron nitride material to the carbon dioxide is promoted.

The invention provides a perovskite solar cell. The perovskite solar cell comprises a conductive substrate; a hole transport layer; a polymer hydrophobic layer; the polymer hydrophobic layer is formed by polymer ionic liquid; a perovskite thin film layer; an electron transport layer; an electrode layer; the polymer ionic liquid comprises a structure as shown in a formula (I). Compared with the prior art, the polymer ionic liquid provided by the invention has hydrophobicity and can effectively block invasion of water vapor to a perovskite layer when being applied; secondly, a monomer in the polymer ionic liquid contains imidazole, C-H in the monomer can form hydrogen bonds with halogen atoms in the perovskite, the interaction between a polymer chain and the perovskite is enhanced, and the phase change of the perovskite is inhibited; in addition,-SO3-at one end of the polymer ionic liquid can be combined with Pb < 2 + > in perovskite through electrostatic interaction, phase change of the polymer ionic liquid is further inhibited, and Pb leakage is reduced.

The invention discloses an oral colon-targeted silicon nano-drug and application thereof, and belongs to the technical field of drug targeted delivery. According to the oral colon targeting delivery system based on biodegradable nano-silica, entrapment of drug molecules can be synchronously achieved in the preparation process, and the targeting effect of the system on inflammatory endothelial cells and macrophages is enhanced through surface modification of hyaluronic acid. In order to ensure the stability of the delivery system in the gastrointestinal tract and avoid the influence of strong acid environment, enzyme and the like in the stomach on the protein, the surface of the delivery system is further modified with chitosan and sodium alginate through electrostatic interaction. The hyaluronic acid, the chitosan and the sodium alginate are used as natural polymer materials and have good biocompatibility. A novel neurotrophic factor MANF is used as a model protein, the MANF protein is successfully delivered to a colon part by constructing an oral colon targeting delivery system, and it is proved that the MANF protein can improve ulcerative colitis injury through oral administration on the animal level.

The invention discloses CD44-mediated self-assembled nanoparticles as well as a preparation method and application thereof, and belongs to the technical field of biology. The CD44-mediated self-assembled nanoparticles are formed by self-assembling polylysine with a phenylboronic acid side chain and dopamine-modified hyaluronic acid through electrostatic interaction, and the side-chain phenylboronic acid of the polylysine is connected with the side-chain dopamine on the hyaluronic acid through a covalent bond. The surface of the nanoparticle is connected with a target protein binding unit through a linker, and the target protein binding unit is used for binding a target protein. The synthesis process is simple, the components are safe, the prepared CD44-mediated self-assembled nano material can efficiently degrade tumor cell extracellular proteins such as PD-L1 and HER2, the specificity is high, the degradation rate is high, and the CD44-mediated self-assembled nano material has a very good application prospect in the field of treatment of diseases such as tumors.

The invention belongs to the field of oil and gas exploitation, and particularly relates to a carbon dioxide-salt double-response polymer thickening agent and a preparation method thereof. The carbon dioxide-salt double-response polymer thickening agent provided by the invention is prepared from acrylamide, acrylic acid, alkyl polyether acrylate and amine carbon dioxide response monomers through solution polymerization; after corresponding monomers of amine carbon dioxide are protonated, polymer molecular chains are better stretched through electrostatic interaction, the viscosity of the fracturing fluid can be increased, complexation and crosslinking of oxyethyl, oxypropyl and calcium and magnesium ions are facilitated, and therefore the tackifying effect of alkyl polyether acrylate is improved; meanwhile, oxyethyl and oxypropyl jointly regulate and control the tightness degree of a network structure, so that a calcium and magnesium ion'salt bridge 'tackifying effect is presented. According to the carbon dioxide-salt double-response polymer thickening agent provided by the invention, the viscosity of the thickening agent is improved through carbon dioxide and calcium and magnesium ions, and meanwhile, a fracturing fluid has certain imbibition oil displacement capacity after gel breaking.

A microscopic comparison and experimental verification method for the wettability of similar surfactants to coal dust, comprising the following steps: S1, collecting an on-site coal sample from a mining area, crushing into powder, and then performing infrared spectrographic analysis and nuclear magnetic resonance spectrographic analysis to obtain information of functional groups and carbon structures of coal molecules; S2, constructing a surfactant-coal electrostatic interaction model, and analyzing an orbital energy difference and an electrostatic potential difference between surfactant molecules and the coal molecules; S3, analyzing the strength and energy of hydrogen bonds between surfactants and water molecules, wherein the strength is determined by bond angles and bond lengths of the hydrogen bonds; S4, constructing a surfactant-coal-water molecule periodic solution model, and performing geometric optimization on the surfactant-coal-water molecule periodic solution model, so that the surfactant-coal-water molecule periodic solution model reaches a stable configuration; S5, performing NPT simulation and NVT simulation on the periodic solution model; and S6, performing experimental verification, so that the problems of long experimental time and high cost and the like of current selection of surfactants can be effectively solved, and a simple and effective thought is provided for the selection of surfactants.

The invention discloses a covalent organic framework with oxidation-reduction activity and a bionic nano-channel structure as well as a preparation method and application of the covalent organic framework, and belongs to the technical field of environmental protection. According to the preparation method, 2, 4-dihydroxybenzene-1, 3, 5-tricarboxaldehyde and 2, 5-bis (allyloxy) terephthaloyl hydrazine are taken as raw materials, a two-dimensional covalent organic framework with oxidation-reduction activity is synthesized, and then a sulfonic acid group with negative charges is covalently grafted, so that a functional material with a bionic nano-channel structure is formed. The material has regular porous channels and rich functional sites, the porous channels provide efficient mass transfer paths and adsorption spaces for uranyl ions, and the functional sites realize specific recognition of the uranyl ions through oxidation-reduction reaction and electrostatic interaction, so that the material shows synergistic advantages of strong selectivity, high adsorption capacity and rapid adsorption kinetics on uranium. The method is simple and low in cost, and the prepared material is clear in structure, good in hydrophilicity, capable of efficiently adsorbing uranyl ions and good in application prospect.

The invention discloses a chitosan-casein peptide nano-particle and a preparation method and application thereof, and belongs to the technical field of food manufacturing, chitosan and casein peptide are combined into a nano-composite with the particle size of 10-1000 nm through electrostatic interaction in a non-covalent binding mode, and the nano-composite is used for preparing the chitosan-casein peptide nano-particle. A more stable oil-in-water emulsion can be prepared by utilizing the nano composite; the invention also provides a preparation method and application of the chitosan-casein peptide nanocomposite, and a preparation method of the oil-in-water emulsion. The nano-composite prepared by the invention has relatively strong oxidation resistance, foamability and foaming stability when the ratio of chitosan to casein peptide is 1: 1, and an oil-in-water emulsion prepared from the nano-composite has good storage stability, pH stability and ion stability. The preparation method of the nanocomposite is simple and low in cost, and has a good application prospect.

The invention discloses forsythin lipidosome, forsythin gel and a preparation method of the forsythin lipidosome and the forsythin gel, and belongs to the technical field of medical materials. The forsythin liposome with high skin transmittance and high bioavailability is prepared by taking forsythin, cholesterol, lecithin and penetration enhancer as raw materials. The penetration enhancer not only can increase the skin permeability of the medicine and improve the skin transmittance, but also can regulate and control the forsythin liposome to carry positive charges, and the forsythin liposome with the positive charges is better combined with the skin with negative charges, so that the skin permeability of the liposome is promoted; the phillyrin lipidosome with positive electricity has strong electrostatic interaction with bacteria, cell membranes of the bacteria can be destroyed, substances in bacterial cells are leaked, bacteria apoptosis is caused, and a good skin antibacterial effect is further achieved.