831 results about "Electrostatic interaction" patented technology

The invention relates to the technical field of petrochemical engineering, and discloses a temperature-resistant anti-swelling agent for fracturing and a preparation process thereof.The preparation method comprises the steps that glycerol triglycidyl ether and diethanol amine are subjected to a ring-opening reaction, a polyhydroxy tertiary amine monomer is obtained, then the polyhydroxy tertiary amine monomer and chloromethylated polystyrene are subjected to a quaternization reaction, and the temperature-resistant anti-swelling agent for fracturing is obtained. Quaternary ammonium salt groups of the anti-swelling agent and negative charges on the surface of clay form electrostatic interaction, and hydroxyl groups and the surface of the clay form hydrogen-bond interaction, so that the anti-swelling agent can be firmly adsorbed on the surface of the clay to form a layer of polymer film, the clay is prevented from being in contact with water, the phenomenon that the clay swells when encountering water is effectively inhibited, and the anti-swelling rate is very high. And the anti-swelling agent contains a heat-resistant polystyrene molecular chain, has excellent high temperature resistance, can maintain good structural stability at high temperature, still maintains high anti-swelling rate, and is suitable for a fracturing fluid system for high-temperature oil reservoir exploitation.

The invention discloses a method and device for predicting protein-ligand binding affinity based on distance and atomic contact number, comprising: acquiring a data set of protein-ligand binding affinity, the data set comprising: atomic information of a protein receptor and atomic information of a ligand; classifying atoms of a protein-ligand compound in the data set according to a preset atom type, and calculating a distance and an atom contact number of an atom pair of a protein-ligand in the data set according to the atom type; training a preset model by taking the protein-ligand distance and the atom contact number as training data to obtain a protein-ligand binding affinity prediction model; and obtaining to-be-predicted protein-ligand data information, inputting the to-be-predicted protein-ligand data information into the protein-ligand binding affinity prediction model, and outputting the to-be-predicted protein-ligand binding affinity. The method is not limited to the power exponent of the distance in the traditional electrostatic interaction energy and Van der Waals interaction energy, and the prediction capability of the affinity is improved.

The invention belongs to the technical field of biomedical materials, and discloses injectable heterogeneous cascade nano-enzyme antibacterial hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: in a process of preparing cerium dioxide nano-enzyme by a reverse micelle method, introducing molybdenum disulfide nano-particles with a nano flower-shaped structure so as to deposit the cerium dioxide nano-enzyme on the surfaces of the molybdenum disulfide nano-particles in situ to obtain nano-composite particles; through electrostatic interaction, glucose oxidase is loaded on the surfaces of the nano composite particles to form a heterogeneous cascade nano enzyme material; the preparation method comprises the following steps: uniformly mixing sodium alginate and hyaluronic acid in water, and sequentially adding an NO donor, a heterogeneous cascade nano-enzyme material and a cross-linking agent to obtain the injectable heterogeneous cascade nano-enzyme antibacterial hydrogel. The preparation method is simple, and the injectable heterogeneous cascade nano-enzyme antibacterial hydrogel has a strong antibacterial effect and can be used for preparing the antibacterial hydrogel. Particularly, the compound has a remarkable killing effect on gram-negative bacteria and gram-positive bacteria.

The invention relates to the technical field of heavy metal recovery, in particular to a method for recovering heavy metal from metal waste. Comprising the following steps: preparing silicon-tungsten composite acid salt; preparing heteropolyacid powder; preparing a resin heteropolyacid composite material; heavy metals are recovered from metal wastes by a resin adsorption method. The silicon-tungsten composite acid salt is prepared under mild conditions through reaction of sodium metasilicate, sodium tungstate and potassium chloride, the operation is simple, the conditions are easy to control, the silicon-tungsten composite acid salt has rich active sites and a large specific surface area, the surface of the silicon-tungsten composite acid salt carries negative charges, and the surface of the silicon-tungsten composite acid salt is not prone to damage. Compared with a traditional chemical precipitation method, the method for extracting the heavy metal by using the silicon-tungsten composite acid salt does not need to add a large number of chemical reagents, and secondary pollution is reduced.

The invention belongs to the technical field of wearable equipment, and particularly relates to a hydrated salt phase change gel material, a preparation method thereof, wearable equipment and a preparation method thereof. The hydrated salt phase change gel material provided by the invention is prepared from the following raw materials in percentage by mass: 30 to 97.7 percent of hydrated salt, 1 to 40 percent of gel monomer, 0 to 20 percent of conductive and heat-conducting filler, 0.1 to 5 percent of cross-linking agent, 0.1 to 5 percent of initiator, 0 to 40 percent of high polymer material, 0 to 10 percent of nucleating agent, 0.05 to 2.5 percent of additive and 0 to 40 percent of water. A gel network in the hydrated salt phase change gel material has a large number of hydrophilic groups, hydrated salt is adsorbed through hydrogen bonds and electrostatic interaction, leakage of the hydrated salt can be prevented, it can be guaranteed that the hydrated salt is evenly distributed in the gel network, phase separation is avoided, and use safety is improved.

The invention relates to a regenerated cellulose-based composite metal organic framework diaphragm as well as a preparation method and application thereof. The diaphragm comprises: a substrate, which is made of regenerated cellulose; the surface of the regenerated cellulose is connected with a sulfonic acid group; the sulfonic acid group establishes a 3D sulfonic acid group network on the surface of the regenerated cellulose; the metal organic framework is arranged on the surface of the substrate; the metal organic framework and the regenerated cellulose can be connected at least through electrostatic interaction and coordination bond interaction. The technical problem to be solved is how to provide a composite diaphragm formed by tightly and stably combining regenerated fibers and a metal organic framework, so that the prepared diaphragm is good in mechanical property and electrochemical property.

The invention discloses a novel long-acting bird repellent and a preparation method thereof, and belongs to the technical field of chemical bird repelling. The bird repellent is composed of a core material and a wall material, the core material is a mixture of geraniol, cinnamyl aldehyde and allicin according to the mass ratio of 1: (1.2-1.5): (0.5-0.8), the wall material is modified beta-cyclodextrin and pumpkin seed protein nanoparticles, and the mass ratio of the geraniol, the cinnamyl aldehyde and the allicin is (5-7): (3-5): (1-3). The preparation method comprises the following steps: preparing the quaternary ammonium salt modified beta-cyclodextrin, including the core material, performing high-speed shearing emulsification on the quaternary ammonium salt modified beta-cyclodextrin and the pumpkin seed protein nano dispersion liquid, and performing freeze drying to obtain a final product. According to the invention, a stable and compact'molecular inclusion + physical barrier 'dual slow-release structure is constructed by utilizing the electrostatic interaction between the positively charged modified beta-cyclodextrin and the negatively charged protein nanoparticles, the release time of effective components is remarkably prolonged to 9 months or more, and the composite material has excellent rain wash resistance and ultraviolet resistance, and can be used for preparing a composite material with a good application prospect. And efficient, environment-friendly and long-acting bird repelling is realized.

The invention discloses an oral monoclonal antibody micro-coated nanopolysaccharide microsphere preparation for targeted therapy of inflammatory bowel diseases and a preparation method thereof. According to the method, oxidized mannan and an anti-TNF-alpha monoclonal antibody are mixed and cross-linked by a cross-linking agent containing a diselenide bond to form the drug-loaded nanoparticles. Mixing the drug-loaded nanoparticles with pectin, dropwise adding the mixture into a calcium chloride solution through an electrostatic spinning device, and carrying out ionic crosslinking to obtain the oral monoclonal antibody micro-coated nano polysaccharide microsphere preparation with the particle size range of 180-200 microns. The drug-loaded polysaccharide microsphere delivers the wrapped drug-loaded nanoparticles to a colitis disease part through electrostatic interaction. The drug-loaded nanoparticles are targeted to macrophages, release of the monoclonal antibody is accelerated under the triggering of high-concentration active oxygen at an inflammation part, and the oral stability and the treatment effect of the monoclonal antibody drug are improved. The polysaccharide is used as a monoclonal antibody targeted delivery carrier, raw materials are cheap and easy to obtain, the preparation process is simple and convenient, reaction conditions are mild, and application and development are easy.

The invention provides a medicine composition containing vinloxacin hydrochloride. The medicine composition comprises a quick-release pellet and a sustained-release pellet. The pharmaceutical composition provided by the invention has the advantages of good stability, capability of simultaneously meeting the specific requirement on in-vitro dissolution of the viloxin hydrochloride, small variety and dosage of auxiliary materials, higher safety and suitability for preparation of a preparation. And the protective layer is sprayed on the outer surface of the sustained-release layer, so that the advantages of weakening the electrostatic interaction of the pellets and preventing the particles from caking in the aging process are further achieved. In addition, the invention also provides a preparation method of the pharmaceutical composition, and the method has the advantages of high drug application rate, less fine powder, no filter bag and spray gun head blockage phenomenon, and suitableness for industrial production and application.

The invention belongs to the technical field of adsorbents, and provides a boron nitride-based material and a preparation method and application thereof.The method comprises the following steps that boric acid, melamine and water are mixed and then added into a metal salt solution, and a precursor is obtained; and pyrolyzing the precursor in a protective atmosphere to obtain the boron nitride-based material. The porous boron nitride fiber material loaded with the alkaline metal ions is prepared through a pyrolysis method, and the porous boron nitride fiber material is rich in structural defects, low in density, excellent in chemical inertness, high in oxidation resistance and free of toxicity, so that the porous boron nitride fiber material is suitable for being used as a carrier of the metal ions; therefore, the carbon dioxide adsorption capacity of the pure boron nitride material is further improved. According to the boron nitride material loaded with the alkaline metal ions, the electrostatic interaction and adsorption energy of the boron nitride material to carbon dioxide are enhanced, so that the adsorption of the boron nitride material to the carbon dioxide is promoted.

The invention provides a perovskite solar cell. The perovskite solar cell comprises a conductive substrate; a hole transport layer; a polymer hydrophobic layer; the polymer hydrophobic layer is formed by polymer ionic liquid; a perovskite thin film layer; an electron transport layer; an electrode layer; the polymer ionic liquid comprises a structure as shown in a formula (I). Compared with the prior art, the polymer ionic liquid provided by the invention has hydrophobicity and can effectively block invasion of water vapor to a perovskite layer when being applied; secondly, a monomer in the polymer ionic liquid contains imidazole, C-H in the monomer can form hydrogen bonds with halogen atoms in the perovskite, the interaction between a polymer chain and the perovskite is enhanced, and the phase change of the perovskite is inhibited; in addition,-SO3-at one end of the polymer ionic liquid can be combined with Pb < 2 + > in perovskite through electrostatic interaction, phase change of the polymer ionic liquid is further inhibited, and Pb leakage is reduced.

The invention belongs to the field of oil and gas exploitation, and particularly relates to a carbon dioxide-salt double-response polymer thickening agent and a preparation method thereof. The carbon dioxide-salt double-response polymer thickening agent provided by the invention is prepared from acrylamide, acrylic acid, alkyl polyether acrylate and amine carbon dioxide response monomers through solution polymerization; after corresponding monomers of amine carbon dioxide are protonated, polymer molecular chains are better stretched through electrostatic interaction, the viscosity of the fracturing fluid can be increased, complexation and crosslinking of oxyethyl, oxypropyl and calcium and magnesium ions are facilitated, and therefore the tackifying effect of alkyl polyether acrylate is improved; meanwhile, oxyethyl and oxypropyl jointly regulate and control the tightness degree of a network structure, so that a calcium and magnesium ion'salt bridge 'tackifying effect is presented. According to the carbon dioxide-salt double-response polymer thickening agent provided by the invention, the viscosity of the thickening agent is improved through carbon dioxide and calcium and magnesium ions, and meanwhile, a fracturing fluid has certain imbibition oil displacement capacity after gel breaking.

The invention discloses a covalent organic framework with oxidation-reduction activity and a bionic nano-channel structure as well as a preparation method and application of the covalent organic framework, and belongs to the technical field of environmental protection. According to the preparation method, 2, 4-dihydroxybenzene-1, 3, 5-tricarboxaldehyde and 2, 5-bis (allyloxy) terephthaloyl hydrazine are taken as raw materials, a two-dimensional covalent organic framework with oxidation-reduction activity is synthesized, and then a sulfonic acid group with negative charges is covalently grafted, so that a functional material with a bionic nano-channel structure is formed. The material has regular porous channels and rich functional sites, the porous channels provide efficient mass transfer paths and adsorption spaces for uranyl ions, and the functional sites realize specific recognition of the uranyl ions through oxidation-reduction reaction and electrostatic interaction, so that the material shows synergistic advantages of strong selectivity, high adsorption capacity and rapid adsorption kinetics on uranium. The method is simple and low in cost, and the prepared material is clear in structure, good in hydrophilicity, capable of efficiently adsorbing uranyl ions and good in application prospect.

The invention discloses a chitosan-casein peptide nano-particle and a preparation method and application thereof, and belongs to the technical field of food manufacturing, chitosan and casein peptide are combined into a nano-composite with the particle size of 10-1000 nm through electrostatic interaction in a non-covalent binding mode, and the nano-composite is used for preparing the chitosan-casein peptide nano-particle. A more stable oil-in-water emulsion can be prepared by utilizing the nano composite; the invention also provides a preparation method and application of the chitosan-casein peptide nanocomposite, and a preparation method of the oil-in-water emulsion. The nano-composite prepared by the invention has relatively strong oxidation resistance, foamability and foaming stability when the ratio of chitosan to casein peptide is 1: 1, and an oil-in-water emulsion prepared from the nano-composite has good storage stability, pH stability and ion stability. The preparation method of the nanocomposite is simple and low in cost, and has a good application prospect.

The invention belongs to the technical field of stamping machining feeding, and particularly relates to automatic feeding equipment of a continuous stamping die, which comprises an automatic feeding machine, the automatic feeding machine is arranged on one side of stamping die equipment and is used for automatically feeding the stamping die equipment, a feeding cavity is formed in the automatic feeding machine, paired feeding rollers are arranged in the feeding cavity, and the feeding rollers are connected with the automatic feeding machine. The feeding roller is connected with power equipment on the inner wall of the feeding cavity; the compacting plates on the upper side and the lower side are controlled to be close to the surface of the metal coiled material, meanwhile, airflow containing positive and negative ions is released, the electrostatic adsorption effect between metal chippings and the metal coiled material is reduced, and the metal chippings are promoted to be separated from the surface of the metal coiled material along with the flowing airflow and enter the recycling cavity along with the airflow; the defect that metal scraps on the surface of the metal coiled material are difficult to clean normally due to the electrostatic interaction is effectively overcome, purification treatment on the metal scraps attached to the surface of the metal coiled material is achieved, and the surface quality of the metal coiled material is improved.

The invention discloses a manganese-enriched albumin boron-containing nano preparation as well as a preparation method and application thereof, and belongs to the field of medicines and nano biological materials. According to the manganese-enriched albumin boron-containing nano preparation, albumin serves as a core carrier, phenylboronic acid derivatives are loaded through covalent or electrostatic interaction, then a manganese oxide layer is deposited on the surface in situ, and the prepared manganese-enriched albumin boron-containing nano preparation can remarkably increase the boron accumulation amount in tumor tissue; local and systemic immune response of tumors is promoted through the immune activation effect of manganese ions, so that the treatment effect of boron neutron capture therapy (BNCT) is remarkably improved. According to the invention, a phenylboronic acid derivative with tumor targeting is compounded with albumin, and manganese oxide is deposited in situ on the surface of the phenylboronic acid derivative, so that a multifunctional nano preparation with high boron delivery efficiency, immunological enhancement and magnetic resonance imaging functions is formed.

The invention provides a bionic zwitterionic polymer which comprises a porous polymer base membrane, the surface of the porous polymer base membrane is loaded with polydopamine and a bionic zwitterionic polymer. According to the bionic zwitterionic polymer modified membrane disclosed by the invention, a dopamine monomer and a zwitterionic polymer containing dopamine and amine oxide structural units are utilized to carry out hydrophilic modification on a substrate; wherein the amine oxide zwitterions can form a hydration layer on the surface of the film through hydrogen bonds and electrostatic interaction to serve as a barrier, so that oil molecules are not easily adsorbed on the surface of the film, and the super-hydrophilic and underwater super-oil-transportation net film is prepared; in addition, zwitter-ions are firmly fixed on the surface of a substrate due to super-strong adhesiveness generated by oxidative auto-polymerization of catechol groups in the polydopamine particles and the zwitter-ion copolymer, and the coating prepared by co-deposition is more stable than a coating prepared by single dopamine, has good chemical stability, structural stability and recyclability, and can be applied to the field of chemical engineering. And the service life is longer.

The invention discloses a three-dimensional porous carbon encapsulated V2O5 carbon fiber electrode constructed by in-situ growth and a preparation method and application thereof, belongs to the technical field of aluminum ion battery positive electrode materials, and aims to solve the problems that the intercalation and deintercalation dynamics of AlCl4 in a polyacrylonitrile (Pan)-based carbon fiber is blocked due to disordered graphite structure, and the performance of the Pan-based carbon fiber is influenced. And the material cannot be used as an effective electrode material to be applied to an aluminum ion battery system. According to the preparation method, an in-situ growth technology is adopted, a three-dimensional porous carbon substrate is grown on the surface of carbon fiber, then an orthorhombic system vanadium pentoxide (V2O5) nano material which has high theoretical specific capacity and can realize large-current charging and discharging is packaged in the three-dimensional porous carbon substrate, and the V2O5-based carbon fiber electrode is prepared. According to the electrode, the electrostatic interaction between Al < 3 + > ions and crystal lattices is effectively relieved, the structural advantages of the carbon fibers and the energy storage performance of V2O5 are fully combined, the energy storage effect of the aluminum ion battery is remarkably improved, and a new effective scheme is provided for development of aluminum ion battery electrode materials.

The invention relates to the technical field of chitosan, and discloses a preparation method and application of a functional water-absorbing chitosan material, an aldehyde triazine quaternary ammonium salt cross-linking agent and amino of chitosan are subjected to a cross-linking reaction, hydrophilic quaternary ammonium salt and sulfonic acid are grafted into the chitosan material, and the hydrophilicity of chitosan is remarkably improved. And the aldehyde triazine quaternary ammonium salt cross-linking agent contains three aldehyde groups, and forms a porous structure of a space cross-linked network with the chitosan, so that the water absorption rate is greatly increased. The chitosan material contains functional quaternary ammonium salt cation groups which can form electrostatic interaction with Cr2O7 < 2-> anions, meanwhile, nitrogen atoms in sulfonic acid groups, nitrogen-rich triazine and imidazole structures can generate coordination chelation with metal ions such as Cu < 2 + >, and the equilibrium adsorption capacity of the chitosan material to Cu < 2 + > is improved. The method has a wide application prospect in the field of metal-containing sewage treatment.

The invention discloses a fibroin / zein-based dual-protein nanocapsule and a preparation method and application thereof.The dual-protein nanocapsule is prepared through a microfluidic-assisted nano-coprecipitation technology and comprises the following steps that silk fibroin is dissolved in a citric acid aqueous solution, and a mixed solution is obtained; the preparation method comprises the following steps: dissolving zein, curcumin and linseed oil in ethanol, rapidly mixing through a microchannel, and carrying out nano coprecipitation to obtain the dual protein nanocapsule. Through electrostatic interaction and amphiphilic regulation, a stable double protein shell structure is formed, curcumin is effectively protected from being damaged by gastric acid and digestive juice, targeted release of intestinal tracts is achieved, and the bioavailability of curcumin is remarkably improved. The obtained nanocapsule is uniform in particle size and good in dispersity, is suitable for a functional beverage system, and has a wide application prospect.

The invention relates to the field of polycrystalline silicon recovery and hydrogen purification, in particular to a modified adsorbent as well as a preparation method and application thereof. The first ion component, the second ion component and the alkaline earth metal component are loaded on the porous carrier, and the types and contents of the first ion component and the second ion component are limited, so that the surface electronic environment of the porous carrier is greatly improved, and the electrostatic interaction with methane molecules is further enhanced; therefore, the adsorption capacity is improved.

The invention relates to a lithium battery negative electrode slurry dispersion method, which comprises: (1) adding a negative electrode main material, a conductive agent, a thickening agent and a dispersant into a homogenizer, and carrying out rapid stirring and slow stirring so as to uniformly mix the powder; (2) adding part of water into the mixed powder obtained in the step (1), stirring at a slow speed, and preliminarily wetting the mixed powder; (3) after the step (2) is finished, adding a binder, continuously stirring at a low speed, uniformly mixing with the binder, fully stirring and dispersing, and obtaining kneaded slurry after stirring; and (4) scraping after the step (3) is finished, adding the residual water, simultaneously stirring at a high speed and a low speed, cooling, vacuumizing and screening to obtain the final negative electrode slurry. According to the method disclosed by the invention, on the premise of ensuring the viscosity of the slurry, the graphite is effectively dispersed through electrostatic interaction, and on the premise of maintaining the viscosity stability of the slurry, the dispersity of the slurry is greatly improved.

The invention discloses a nitrogen / boron-doped non-noble metal-based material, a synthesis method thereof and application of the nitrogen / boron-doped non-noble metal-based material in a microbial fuel cell. According to the method, a carbon fiber brush is used as a substrate, urea and sodium borohydride are used as a nitrogen source and a carbon source respectively, and the nitrogen / boron doped non-noble metal-based material is synthesized through a hydrothermal method. The electrostatic interaction between graphene oxide and FeCoNi-LDH is utilized to realize tight combination, so that FeCoNi-LDH nanosheets are uniformly dispersed on the surface of the carbon fiber brush, and the problems that LDHs are easy to agglomerate and poor in conductivity are solved; in the boron / nitrogen co-doping process, an efficient electron transmission channel is constructed by adjusting the electronic structure of the composite material, and the material is endowed with excellent electron transmission capability and oxygen reduction performance. In an MFC (Microbial Fuel Cell) test constructed by taking a nitrogen / boron-doped non-noble metal-based material as a cathode, the output voltage and the maximum power density are several times of those of commercial Pt / C and a blank carbon fiber brush, and the carbon fiber brush has a wide application prospect in the field of microbial fuel cells.

The invention relates to a chitosan-collagen synergistic self-assembly fiber material and a preparation method thereof, and belongs to the technical field of biological fiber materials. According to the method, the mass ratio of chitosan to collagen is controlled, co-assembly is induced through hydrogen bonds and electrostatic interaction in a low-temperature PBS solution, and then glutaraldehyde crosslinking, gradient dehydration and supercritical drying are performed to prepare the freeze-dried fiber. The obtained material completely retains the triple helix conformation of collagen, and has excellent conformation stability and enzymolysis resistance. The mechanical strength of the composite fiber is remarkably improved, and the composite fiber has excellent antibacterial property and cell affinity. The process does not need a toxic cross-linking agent, the operation is simple and convenient, and the prepared fiber is suitable for the high-end biomedical fields of tissue engineering scaffolds, intelligent antibacterial dressings, degradable nerve conduits and the like.

The invention discloses a bio-based recoverable high-thermal-conductivity dynamic ordered network composite material and a preparation method thereof, and is characterized in that the material takes a bio-based multifunctional epoxy system and a carboxylic acid compound containing disulfide bonds as reaction monomers, and the reaction monomers are reacted under the conditions of high temperature and metal salt catalyzed epoxy-carboxylic acid esterification reaction to obtain the bio-based recoverable high-thermal-conductivity dynamic ordered network composite material. A dynamic ordered network structure simultaneously containing disulfide bonds and beta-hydroxyl ester bonds is constructed, and the dynamic ordered network can be used as a springboard for phonon transmission, serves as an efficient'thermal bridge ', and plays a role similar to an ordered'crystal domain', so that higher heat-conducting property is shown when heat-conducting filler is not introduced, high flexibility and intrinsic heat conduction are realized, and the service life of the material is prolonged. And the material is endowed with reprocessing and recycling characteristics. Due to the synergistic existence of carboxyl, hydroxyl generated by epoxy ring opening and metal coordination in the system, and in combination with electrostatic interaction, Van der Waals force and hydrophobic interaction, the material has the adhesion characteristic suitable for a thermal interface at the same time.

The invention discloses an asiatic acid elastic self-adaptive liposome as well as a preparation method and application thereof. The betaine and the lipidosome are utilized to synergistically improve the membrane stability, permeability and binding capacity of the lipidosome, the asiatic acid lipidosome synthesized by the asiatic acid instead of cholesterol is used as a delivery carrier of the exosome to improve the skin microenvironment and increase the effective utilization rate, and the Tween 80 is utilized to reduce the membrane surface tension of the lipidosome. Meanwhile, sodium deoxycholate is adopted to enhance the electrostatic interaction between the liposome and the skin, so that the liposome can generate reversible shape change when exposed to external stimulation, and the transdermal efficiency and the stability of the liposome are improved again while certain self-adaption is achieved. Finally, a lipid nano-carrier capable of realizing exosome non-invasive efficient transdermal delivery, remodeling a skin microenvironment and treating skin related diseases is constructed. A new thought is provided for transdermal delivery and clinical application of the exosome.

Specifically, firstly, montmorillonite (MMT) powder is stripped into a nanosheet layer by using an ultrasonic dispersion technology, a two-dimensional layered structure of the nanosheet layer forms rich nanoscale ion channels, and an efficient path is provided for ion directional migration in salinity gradient power generation; meanwhile, after the cellulose is stripped and dispersed by a DMSO solution, a uniform polymer network is formed, the uniform polymer network is used as a substrate material to improve the mechanical strength of the film, and the interfacial ion adsorption and conduction capability is optimized through hydrophilic groups. When the MMT nanosheet and the cellulose suspension are mixed, the MMT nanosheet and the cellulose suspension form an interpenetrating network structure through physical winding and electrostatic interaction, ordered stacking is achieved through vacuum filtration, and finally the composite film with both ion selectivity and structural stability is formed on the substrate. The preparation process is high in material adaptability, green and controllable in preparation process, high in competitiveness in large-scale production and practical application and beneficial to popularization.

The invention provides a capacitive pressure and humidity dual-mode sensor and a preparation method thereof, and belongs to the technical field of sensors. A carbon composite material-based sensor is used as a pressure sensing module, and a metal-organic framework compound-based sensor is used as a humidity sensing module. A foam skeleton in the pressure sensing module maintains the mechanical stability of the device, and nanocellulose and reduced graphene oxide enhance the compressive property of the device through a gradient structure induced by self-assembly and gravity, so that the device has good sensitivity and is not interfered by humidity. Hydroxyl groups on organic ligands in the humidity sensing module can react with metal ions through coordination, electrostatic interaction, hydrogen bonds and the like to form a stable MOF structure, so that the stability of metal ion carriers in a metal organic framework is improved, the humidity sensing module is sensitive to humidity, the humidity sensing module has a wide appropriate detection range, and the device can be repeatedly used.

The invention discloses a polymer solid electrolyte containing a zwitterionic monomer and a preparation method and application thereof, and belongs to the technical field of solid-state lithium batteries. The polymer solid electrolyte is prepared by taking a polymer matrix as a substrate and taking a zwitterionic monomer as a functional modified monomer through copolymerization modification. According to the in-situ polymerized zwitterionic monomer polymer solid electrolyte disclosed by the invention, dissociation of lithium salt or other salts can be promoted through electrostatic interaction, so that the lithium ion conductivity of the solid electrolyte is optimized; the ion atmosphere of original anions and lithium ions in the electrolyte can be interfered, so that the migration of the lithium ions is released and promoted. Meanwhile, the movement of anions is inhibited by immobilized cations, the dissociation and migration of lithium ions are further promoted, the transference number of the lithium ions is favorably increased, and the long-term stable circulation of the battery is facilitated. In addition, the preparation method of the electrolyte is simple, the cost is low, and the actual requirement of mass production can be met.

The invention discloses a biological patch material with dry-state adhesion and wet-state easy stripping characteristics and application thereof, and belongs to the field of biological medicine. The biological patch material is prepared according to the following steps: by taking water-soluble protein as a template and copper ions in water-soluble copper salt as a metal coordination center, carrying out self-assembly on the template and drug molecules with phenolic hydroxyl structures to form nanoflowers; mixing the acrylamide, the sodium alginate, the water-soluble calcium salt and the nano-flowers to obtain the water-soluble calcium-based water-soluble nano-flower fertilizer. The biological patch material is adhered to the skin through electrostatic interaction, covalent bonds, physical interpenetration and topological tissues. The patch has skin adhesion in a dry state, so that the patch is convenient to fix; after the patch is in contact with burnt skin, the patch absorbs water and swells, the adhesive force is obviously reduced, and painless, easy and non-invasive stripping is realized. In addition, the patch has immunoregulation performance, can prevent stimulation and anaphylaxis caused by long-term contact with the skin, and promotes burn repair.