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Polymer microsphere containing inorganic nano microparticles, and its preparing method and use

An inorganic nano- and nano-particle technology, applied in biological testing, material inspection, etc., can solve problems such as the inability to control the morphology and crystallinity of the nano-particle surface structure, and the lack of strong enough interaction between the nano-particle and the polymer sphere. , to achieve the effect of convenient operation and simple preparation process

Active Publication Date: 2007-01-10
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the former cannot control the morphology and crystallinity of nanoparticles and the surface structure of nanoparticles (J.Am.Chem.Soc.2004, 126, 7908); Interaction, nanoparticles are easy to precipitate from the matrix under certain conditions (Adv.Mater.2005, 17(3), 267)

Method used

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  • Polymer microsphere containing inorganic nano microparticles, and its preparing method and use
  • Polymer microsphere containing inorganic nano microparticles, and its preparing method and use
  • Polymer microsphere containing inorganic nano microparticles, and its preparing method and use

Examples

Experimental program
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Effect test

Embodiment 1

[0069] Weigh 1.315g cadmium perchlorate (Cd(ClO 4 ) 2 ·6H 2 O) Add to 150mL of deoxygenated secondary water, then add 0.55mL of thioglycolic acid as a modifier, adjust its pH value to 11.2 with 1M sodium hydroxide solution to form a solution containing mercapto compounds and cadmium ions. On the other hand, take 30mL of 0.5M sulfuric acid solution and inject it into a container containing 0.39g of aluminum telluride (Al 2 Te 3 ) in the flask, the generated H 2 Put all the Te into the cadmium ion solution, stir for 15 minutes, and then heat and reflux for 1 minute to 10 days to obtain an aqueous solution of cadmium telluride semiconductor nanoparticles with stable thioglycolic acid and a fluorescent emission center wavelength between 430 and 650 nanometers. Fluorescence spectrum see figure 1 .

Embodiment 2

[0071] Weigh 1.031g cadmium chloride (CdCl 2 2.5H 2 O) Add to 150mL deoxygenated secondary water, then add 0.55mL mercaptopropionic acid as a modifier, adjust its pH value to 11.2 with 1M sodium hydroxide solution to form a solution containing mercapto compounds and cadmium ions. The rest of the steps are the same as in Example 1 to obtain an aqueous solution of cadmium telluride semiconductor nanoparticles with stable mercaptopropionic acid and a central wavelength of fluorescence emission between 430 and 650 nanometers.

Embodiment 3

[0073] Weigh 1.031g cadmium chloride (CdCl 2 2.5H 2 O) Add to 150mL deoxygenated secondary water, then add 0.65mL lipoic acid as a modifier, adjust its pH value to 11.2 with 1M sodium hydroxide solution to form a solution containing mercapto compounds and cadmium ions. The rest of the steps are the same as in Example 1 to obtain an aqueous solution of cadmium telluride semiconductor nanoparticles with stable lipoic acid and a center wavelength of fluorescence emission between 430 and 650 nanometers.

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Abstract

The invention relates to a method for connecting nanoparticles and polymer spheres with chemical bonding in the polymer microspheres and its preparation and biomedical applications, which recombines the water-soluble inorganic nano-particles into hydrophobic polymers with reactive surfactant through emulsion polymerization. In this way, the multi-functional polymer microspheres can be obtained through the recombination of different types of nanoparticles on the same microspheres. The positive charge on the microsphere surface can couple the biological molecules onto it by the electrostatic interaction to get a microsphere fluorescent probe used in immunodetection, chromosome analysis of multiple genes, protein array, DNA sequencing and simultaneous detection in different regions of gene chips and cell or biological tissues.

Description

technical field [0001] The invention belongs to the field of polymer microspheres containing nanoparticles, in particular to the connection between nanoparticles and polymer spheres through chemical bonds, and more specifically to the microspheres formed by compounding inorganic nanoparticles and polymers through emulsion polymerization Its preparation method and application in biomedicine. Background technique [0002] Due to its unique size effect, compared with the corresponding bulk materials, nanoparticles have very unique physical and chemical properties, and have broad application prospects in various fields. At present, the most widely used nanoparticles mainly include semiconductors, noble metals and metal oxides. Combining nanoparticles into hydrophobic polymers can not only isolate nanoparticles from the external chemical environment, so that their unique properties will not be affected by the environment; but also can endow the microspheres with more new functio...

Claims

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Application Information

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IPC IPC(8): C08F2/44C08F2/24C08L25/06C08L31/04C08L33/08C08L33/10C08K9/00G01N33/53
Inventor 高明远杨云华闻中凯董宇平
Owner INST OF CHEM CHINESE ACAD OF SCI
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