5409 results about "Biomedicine" patented technology

A method for designing polypeptides for the nanofabrication of thin films, coatings, and microcapsules by ELBL for applications in biomedicine and other fields.

Generally, decisions are based on information. To be useful, information must be reliable. Basically, the concept of a Z-number relates to the issue of reliability of information. A Z-number, Z, has two components, Z=(A,B). The first component, A, is a restriction (constraint) on the values which a real-valued uncertain variable, X, is allowed to take. The second component, B, is a measure of reliability (certainty) of the first component. Typically, A and B are described in a natural language, for example: (about 45 minutes, very sure). Z-number has many applications, especially in the realms of economics, decision analysis, risk assessment, prediction, anticipation, rule-based characterization of imprecise functions and relations, and biomedicine. Different methods, applications, and systems are discussed. Other Fuzzy concepts are also discussed.

An imaging probe for a biological sample includes an OCT probe and an ultrasound probe combined with the OCT probe in an integral probe package capable of providing by a single scanning operation images from the OCT probe and ultrasound probe to simultaneously provide integrated optical coherence tomography (OCT) and ultrasound imaging of the same biological sample. A method to provide high resolution imaging of biomedical tissue includes the steps of finding an area of interest using the guidance of ultrasound imaging, and obtaining an OCT image and once the area of interest is identified where the combination of the two imaging modalities yields high resolution OCT and deep penetration depth ultrasound imaging.

This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over conventional bioadhesive hydrogels in terms of biocompatibility. In addition, the in situ-forming bioadhesive hydrogel has excellent biocompatibility and mechanical strength and has excellent tissue adhesiveness thanks to modification with/without dopa derivatives. The hydrogel finds a variety of applications in the biomedical field, including bioadhesives or hemostats, implant substances for tissue regeneration and augmentation, carriers for delivering biologically active materials or drugs, etc.

The invention discloses a biomedical material and a product thereof. The biomedical material has main characteristic that a compound having a catechol group structure is grafted on chitosan to form a chitosan biomedical material having the catechol group structure; or the grafted chitosan is cross-linked to prepare a novel macromolecular biomedical material. The catechol has cell adhesion, so that tissue adhesiveness of the chitosan can be changed, and blood cells can be adsorbed on the material surface to achieve better bleeding-steeping effect. By virtue of the mediation, performance of the chitosan is improved, and tissue affinity is improved. The material is prepared into a novel bleeding-stopping sponge by freeze-drying, and prepared into novel dressing by spinning or prepared into powder dressing by reverse flocculating.

The invention relates to a method for preparing micro/nano porous ceramic fibers by low-temperature electrostatic spinning. With combining electrostatic spinning technology and freeze-drying technology, the micro/nano porous ceramic fibers are prepared by freeze-drying and sintering after electrostatic spinning at a low temperature; and the method comprises four steps of preparing a spinning solution, electrostatic spinning at a low temperature, freeze-drying and sintering. The method for preparing micro/nano porous ceramic fibers by low-temperature electrostatic spinning can obtain an extremely high specific surface area, and is beneficial to improving performances of contacting, catalyzing, separating and sensing of ceramic fibers, and has wide application prospects in fields of biomedicine, filter materials, catalyst carriers, fuel cells, electronic element appliances and the like.

The invention discloses an extraction and preparation method for micromolecule fishskin collagen peptide, which comprises the following technical steps of: taking the fishskin of freshwater fish as raw material; removing non-collagenous protein; carrying out steps of degreasing, deodorizing, smashing and the like; under the acidic condition, carrying out heating hydrolysis processing to collagenous protein; controlling the degradation degree of the collagenous protein with an enzymolysis method; obtaining a target micromolecule collagen peptide with a membrane separation method; recycling protease, and then carrying out nanofiltration desalting; and after activated carbon binding resin is decolored and deodorized, carrying out spray drying to obtain the colorless and tasteless micromolecule fishskin collagen peptide. The extraction and preparation method disclosed by the invention has a simple technology, the protease is recycled by membrane separation, and therefore the cost is saved. The prepared micromolecule collagen peptide is colorless and tasteless and can be widely applied to industries relevant to the health of the human body, such as health care food, biomedicine, and cosmetics.

Disclosed are nanostructured gold films which may be produced by solution-phase depositions of gold ions onto a variety of surfaces. The resulting plasmonic gold films are used for enhanced spectroscopic-based immunoassays in multiplexed microarray format with detection mechanisms based on either surface-enhanced Raman scattering or near-infrared fluorescence enhancement. The preparation of the films and subsequent modifications of the gold film surfaces afford increased sensitivity for various microarrays. The films are discontinuous, forming gold “islands.” Sensitivity, size, shape, and density of the nanoscopic gold islands comprising the discontinuous nanostructured gold film are controlled to enhance the intensity of Raman scattering and fluorescence in the near-infrared, allowing for improved measurements in clinical diagnostic or biomedical research applications.

In many areas, recent developments have generated very large datasets from which it is desired to extract meaningful relationships between the dataset elements. However, to date, the finding of such relationships using prior art methods has proved extremely difficult especially in the biomedical arts. Methods for local causal learning and Markov blanket discovery are important recent developments in pattern recognition and applied statistics, primarily because they offer a principled solution to the variable/feature selection problem and give insight about local causal structure. The present invention provides a generative method for learning local causal structure around target variables of interest in the form of direct causes/effects and Markov blankets applicable to very large datasets and relatively small samples. The method is readily applicable to real-world data, and the selected feature sets can be used for causal discovery and classification. The generative method GLL-PC can be instantiated in many ways, giving rise to novel method variants. In general, the inventive method transforms a dataset with many variables into either a minimal reduced dataset where all variables are needed for optimal prediction of the response variable or a dataset where all variables are direct causes and direct effects of the response variable. The power of the invention and significant advantages over the prior art were empirically demonstrated with datasets from a diversity of application domains (biology, medicine, economics, ecology, digit recognition, text categorization, and computational biology) and data generated by Bayesian networks.

The invention relates to a preparation method and an application of a magnetic fluorescent nanoparticle with a shell-core structure. Firstly, a silica magnetic microsphere with a shell-core structure is prepared by using one or more than one of nanoparticles of Fe3O4, gamma-Fe2O3, MeFe2O4 (Me=Co, Mn, Ni), metal Ni, Co, Fe, and alloy Fe-Co, Ni-Fe as the inner core, and coating a silica shell, and then a fluorescent material (a chelate of Eu3+, Sm3+, Dy3+, Tb3+ and the like) is absorbed on the silica shell. Then, a layer of silica is coated on the surface to improve the stability of the fluorescent magnetic microsphere, and to prevent agglomeration and fluorescent material leakage. A lot of rare earth fluorescent materials are wrapped in the shell layer, so the fluorescence intensity signal of a prepared sample is greatly increased. The nanoparticle has dual functions of enrichment and marking, and has wider application prospects in the biomedical field.

The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass sition temperature of the silk film Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices.

Highly fluorescent carbon nanoparticles (FCNs), with tunable emission colours of particle size between 1-10 nm also stable in solid form with high quantum yield (>5%) and its method of synthesis thereof yielding said carbon nanoparticles in milligram to gram scale in high synthesis yield (>80%). The present invention also provides for highly fluorescent carbon nanoparticle solution doped with heteroatom (such as oxygen, nitrogen) and its method of synthesis favoring yield of the said doped carbon nanoparticles of even smaller size ranging from 1-5 nm with narrow size distribution, and also provides for functionalized FCNs that are non-toxic, functional, soluble and stable fluorescent carbon nanoparticles with retained fluorescence for variety of end uses in biomedics, imaging applications, and detection techniques.

The invention discloses a flexible piezoresistive pressure sensor with high sensitivity. The pressure sensor comprises the components of a flexible substrate, metal electrodes and a grid-shaped graphene film layer. The metal electrodes are fixedly connected with two ends of the top surface of the flexible substrate. The graphene film layer covers and is connected with the flexible substrate and partial metal electrodes. The pressure sensor has an advantage that the substrate can perform bending deformation and furthermore has high sensitivity. The pressure sensor can be widely used in the fields of biomedicine, wearable device, etc. Furthermore the invention discloses a preparation method for the flexible piezoresistive pressure sensor.

The invention relates to the technical field of biomedicine, and relates to a biomedicine event trigger word identification method based on characteristic automatic learning. The biomedicine event trigger word identification method comprises the following steps of 1, data pre-processing; 2, construction of an event trigger word dictionary; 3, construction of candidate trigger word examples; 4, characteristic learning by means of a convolutional neural network model; 5, training by means of a neural network model; and 6, classification of event trigger words. The biomedicine event trigger word identification method is advantaged in that 1, complex preprocessing to data is simplified, and tedious steps for carrying out a characteristic design by people are saved; 2, domain knowledge is introduced, and a lot of external resources such as unlabeled linguistic data are effectively utilized; 3, characteristic automatic learning is carried out by means of a convolutional neural network, manual intervention is reduced, sentence level characteristics in a deeper level can be excavated and explored, through the fusion of local characteristics, implicit global characteristics are discovered, and the category of trigger words can be identified; and 4, a better experiment result is obtained in MLEE linguistic data, and the whole performance on event trigger word detection is improved.

The invention is a manufacturing method for quanta point microsphere used as biomedicine fluorescence probe. It belongs to chemical engineering, material and biomedicine field. The invention uses spray and drying method to embeds the quanta point into high molecular material, forms quanta microsphere with particle distribution less than 10 micrometers, the quanta point nanometer particle with different quantity and different fluorescence character is dispersed in the high molecular liquid, then carries on spray and drying, it changes the fluorescence character of the microsphere through changing type of quanta point material, quantity of the quanta point and the color and intensity of the quanta point, controls the particle size and figure of the quanta microsphere through adjusting the condition of spray and drying.