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96results about How to "Enhanced fluorescence emission" patented technology
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Nucleotide analogues comprising a reporter moiety and a polymerase enzyme blocking moiety
InactiveUS7078499B2Enhanced fluorescence emissionEasy to identifySugar derivativesMaterial analysis by observing effect on chemical indicatorPhosphatePolymerase L
Nucleotides comprising a reporter moiety and a polymerase enzyme blocking moiety in which the reporter moiety does not also act as a polymerase enzyme blocking moiety are described. Also described are compounds of Formula (I): wherein W is a phosphate group, B is a base, Y is a linker comprising an enzyme-cleavable group, R2 is a reporter moiety, R3 is selected from H or OH, Z and Z′ are selected from H, OH, or a group X—R1, wherein X is a linker comprising an enzyme-cleavable group and R1 is a polymerase enzyme blocking group, provided that at least one of Z and Z′ is X—R1.
Owner:GE HEALTHCARE LTD
High-sensitivity assays for pathogen detection using metal enhanced fluorescence
ActiveUS20060147927A1Superior high sensitivity detectionReduce detectionSugar derivativesMicrobiological testing/measurementFluorescenceNucleotide
The present invention relates to an assay including a surface having silver colloids or islands attached thereto. Attached to the surface and / or silver colloids / islands are polynucleotides which are complimentary to a target polynucleotide sequence. The assay is performed by adding the target polynucleotide sequence to the assay surface and allowed to hybridize with the capture polynucleotides. Fluorophore-labeled capture polynucleotides are added and hybridize to the target polynucleotide. Bound target polynucleotides are detected by metal enhanced fluorescence.
Owner:UNIV OF MARYLAND BALTIMORE COUNTY
Lamp using solid state source and doped semiconductor nanophosphor
ActiveUS20110175528A1Easy to useHighly desirable characteristicPoint-like light sourceElectric circuit arrangementsElectricityEffect light
A lamp uses a solid state source to pump one or more doped semiconductor nanophosphors to produce a light output of a desired characteristic. The nanophosphor(s) is dispersed in a material, examples of which include liquids and gases. Various nanophosphors are discussed. In the examples, the material with the doped semiconductor nanophosphor(s) dispersed therein appears at least substantially clear when the lamp is off. The exemplary lamp also includes circuitry for driving the solid state source and a housing that at least encloses the drive circuitry. The lamp has a lighting industry standard lamp base mechanically connected to the housing and electrically connected to provide electricity to the circuitry for driving the solid state source.
Owner:ABL IP HLDG
Compositions and methods for visual ribonuclease detection assays
InactiveUS6773885B1Performed rapidly and easilyOvercome deficienciesSugar derivativesMicrobiological testing/measurementRibonucleaseTest sample
The present invention relates to methods for detecting the presence of ribonuclease enzymes, more specifically to methods that provide for a visual detection assay. The methods entail contacting a test sample suspected of containing ribonuclease activity with a substrate containing a ribonuclease-sensitive internucleotide linkage flanked directly or indirectly by a fluorescence reporter group and a dark quencher, such that if a ribonuclease activity is present in the sample, the ribonuclease-sensitive internucleotide linkage is cleaved and the fluorescence reporter group emits a visually detectable signal. The present invention further provides novel nucleic acid compositions used as substrates for such assays and encompasses kits for performing the methods of the invention.
Owner:INTEGRATED DNA TECHNOLOGIES
Coupled recognition/detection system for in vivo and in vitro use
ActiveUS20120252699A1Increase the number ofRapid and simple and general approachFungiMethine/polymethine dyesFluorophoreIn vivo
The present invention relates to novel fluorophores and their use in combination with novel nucleic acid molecules, called aptamers, that bind specifically to the fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.
Owner:CORNELL UNIVERSITY
Fluorescent probe compounds, preparation method and use thereof
InactiveCN101735277AHigh detection sensitivityGood choiceGroup 5/15 element organic compoundsAnalysis by subjecting material to chemical reactionLinear relationshipLinearity
Owner:DALIAN CHROMAS BIOSCI
High-sensitivity assays for pathogen detection using metal enhanced fluorescence
ActiveUS8114598B2Easy to detectReduce detectionSugar derivativesMicrobiological testing/measurementFluorescenceNucleotide
The present invention relates to an assay including a surface having silver colloids or islands attached thereto. Attached to the surface and / or silver colloids / islands are polynucleotides which are complimentary to a target polynucleotide sequence. The assay is performed by adding the target polynucleotide sequence to the assay surface and allowed to hybridize with the capture polynucleotides. Fluorophore-labeled capture polynucleotides are added and hybridize to the target polynucleotide. Bound target polynucleotides are detected by metal enhanced fluorescence.
Owner:UNIV OF MARYLAND BALTIMORE COUNTY
Preparation method of fluorescent probe and application of fluorescent probe in aluminum ion detection
InactiveCN105802608AGood choiceHigh sensitivityOrganic chemistryFluorescence/phosphorescenceAluminum IonReflux
The invention provides a preparation method of a fluorescent probe and an application of the fluorescent probe in aluminum ion detection. The fluorescent probe is obtained by virtue of a reaction in a heating reflux manner between 2-hydroxyl-1-naphthaldehyde and carbohydrazide. In the structure of the fluorescent probe provided by the invention, the N atoms on the C=N double bonds are influenced by a photo-induced electron transfer effect, and after the N atoms are combined with aluminum ions, the photo-induced electron transfer effect is inhibited, and planar conjugation is enhanced at the same time; two mechanisms together induce obvious enhancement of fluorescence emission; the fluorescent probe has good selectivity and sensitivity to the aluminum ions. High-selectivity identification of the aluminum ions is realized, a relatively good linear relation exists in a range of 5*10<-6> to 4*10<-5> mol / L, and the limit of detection is as low as 1.89*10<-8> mol / L, so that the fluorescent probe has a chromogenic sensing function.
Owner:WENZHOU MEDICAL UNIV
Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents
InactiveUS20070020630A1Inhibit and reduce activityHigh activityBiocideHydrolasesCancer preventionSplicing endonuclease
The present invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for treating and / or preventing cancer.
Owner:PTC THERAPEUTICS INC
Fluorescence probe based on 1, 3, 4-oxadiazole derivative, and synthetic method and applications thereof
ActiveCN103642487AEasy to separate and purifyRaw materials are easy to getOrganic chemistryFluorescence/phosphorescenceSolventStructural formula
The invention discloses a fluorescence probe based on 1, 3, 4-oxadiazole derivative, and a synthetic method and applications thereof. Chemical formula of the fluorescence probe is represented in the invention. The synthetic method comprises following steps: N-[2-(5-phenyl-1, 3, 4-oxadiazole-2-yl)phenyl]-2-chloroacetamide, di-(pyridylmethylene)amine, N, N-diisopropylethylamine and potassium iodide are added into acetonitrile so as to obtain a mixture; the mixture is stirred, and is subjected to heating reflux under protection of nitrogen; solvent removing is realized via reduced pressure distillation, and obtained residues are subjected to column chromatography for separation so as to obtain the fluorescence probe N-[2-(5-phenyl-1, 3, 4-oxadiazole-2-yl)phenyl]-2-di(2-pyridylmethylene) acetamide. The raw materials are easily available; the synthetic method is simple; product separation and purification processes are easy; and the fluorescence probe possesses excellent water solubility, can be used for Zn<2+> monitoring analysis and tracer analysis in water environmental systems and biological cell systems, and possesses excellent sensitivity and relatively strong anti-interference capability on detection of Zn<2+>.
Owner:BOHAI UNIV
Compositions and methods for visual ribonuclease detection assays
InactiveUS20040137479A1Rapid and easy to performOvercome deficienciesMonoazo dyesSugar derivativesRibonucleaseFluorescence
The present invention relates to methods for detecting the presence of ribonuclease enzymes, more specifically to methods that provide for a visual detection assay. The methods entail contacting a test sample suspected of containing ribonuclease activity with a substrate containing a ribonuclease-sensitive internucleotide linkage flanked directly or indirectly by a fluorescence reporter group and a dark quencher, such that if a ribonuclease activity is present in the sample, the ribonuclease-sensitive internucleotide linkage is cleaved and the fluorescence reporter group emits a visually detectable signal. The present invention further provides novel nucleic acid compositions used as substrates for such assays and encompasses kits for performing the methods of the invention.
Owner:INTEGRATED DNA TECHNOLOGIES
Preparation method of fluorescent biosensor of double-cycle and double quenching system based on functionalized graphene quantum dots
InactiveCN109593831AGood water solubilityEnhanced fluorescence emission intensityMicrobiological testing/measurementDissolutionQuenching
The invention relates to a preparation method of a fluorescent biosensor of a double-cycle and double quenching system based on functionalized graphene quantum dots. The method comprises the followingsteps: weighing raw materials including citric acid, histidine and pentaethylene hexamine at the molar ratio of 0.01:0.1:1 to 1:1:1, uniformly mixing, adding deionized water, then performing ultrasonic dissolution to obtain a reaction solution, placing the reaction solution in an oven, reacting for 0.5-10h at an oven temperature of 150-250 DEG C to directly obtain a crude product of pentaethylenehexamine-histidine graphene quantum dot PEHA-GQD-His after reaction, then obtaining an LDNA-capped pentaethylene hexamine-histidine graphene quantum dot PEHA-GQD-His solution, finally forming a G-quadruplex / DNase, and finally adding 0.5-100[mu]l of H2O2 with the molar concentration of 0.1-10[mu]M to obtain the fluorescent biosensor of the double-cycle and double quenching system.
Owner:JIANGNAN UNIV
NANO aggregates of molecular ultra small clusters of noble metals and a process for the preparation thereof
ActiveUS20150174657A1Enhanced fluorescence emissionAccelerate emissionsGroup 1/11 element organic compoundsNitrogen compoundsAutocatalysisNanoparticle
The present invention discloses size controlled and stabilized nano-aggregates of molecular ultra small clusters of noble metals and a process for the preparation thereof. The present invention discloses single source multicolor noble metal spherical and uniform nano aggregates of 10-22 nm made up of discrete molecular ultra small noble metal (Nb) nanoclusters (MUSNbNC's) of 1-6 atoms. The MUSNbNC's are capped with amine / DCA (dicarboxy acetone) group acting as a steric and kinetic hindrance for core growth suppressing the further autocatalysis and conversion of super critical nucleus or growth by ripening and formation of nanoparticles and thus having intense fluorescence.
Owner:COUNCIL OF SCI & IND RES
Method and reagent for measuring nitroreductase enzyme activity
InactiveUS7579140B2High fluorescence intensityEnhanced fluorescence emissionCompound screeningApoptosis detectionNitroreductaseTest agent
Disclosed are nitro-substituted squaraine reporter dyes and methods using such dyes for detecting nitroreductase enzyme activity and nitroreductase gene expression in cellular assays. The dyes are of the structure:in which Z1 and Z2 independently represent a phenyl or a naphthyl ring system; X and Y are selected from oxygen, sulphur, —CH═CH— and the group:R1 and R2 are selected from C1-C4 alkyl, —(CH2)n—P, —{(CH2)2—O}p—R6 and group W; where P is selected from COOR7, SO3− and OH, W is mono- or di-substituted nitrobenzyl, R6 is methyl or ethyl, R7 is selected from H, C1-C4 alkyl and CH2OC(O)R8, where R8 is methyl, or t-butyl, n is an integer from 1 to 10, and p is an integer from 1 to 3; R3 and R4 are selected from hydrogen, NO2, halogen, SO3−, C1-C4 alkoxy and —(CH2)m—COOR7; where R7 is hereinbefore defined and m is 0 or an integer from 1 to 5; R5 is C1-C6 alkyl optionally substituted with COOR7, SO3−, or OH; where R7 is hereinbefore defined; and at least one of groups R1, R2, R3 and R4 comprises at least one NO2 group. Also provided are methods for screening for a test agent whose effect upon nitroreductase enzyme activity and nitroreductase gene expression is to be determined.
Owner:GE HEALTHCARE LTD
Method and Reagent for Measuring Nitroreductase Enzyme Activity
InactiveUS20080317674A1Fluorescent signal enhancementHigh fluorescence intensityUltrasonic/sonic/infrasonic diagnosticsCompound screeningTest agentNitroreductase
Disclosed are nitro-substituted squaraine reporter dyes and methods using such dyes for detecting nitroreductase enzyme activity and nitroreductase gene expression in cellular assays. The dyes are of the structure:in which Z1 and Z2 independently represent a phenyl or a naphthyl ring system; X and Y are selected from oxygen, sulphur, —CH═CH— and the group:R1 and R2 are selected from C1-C4 alkyl, —(CH2)n—P, —{(CH2)2—O}p—R6 and group W; where P is selected from COOR7, SO3− and OH, W is mono- or di-substituted nitrobenzyl, R6 is methyl or ethyl, R7 is selected from H, C1-C4 alkyl and CH2OC(O)R8, where R8 is methyl, or t-butyl, n is an integer from 1 to 10, and p is an integer from 1 to 3; R3 and R4 are selected from hydrogen, NO2, halogen, SO3−, C1-C4 alkoxy and —(CH2)m, —COOR7; where R7 is hereinbefore defined and m is 0 or an integer from 1 to 5; R5 is C1-C6 alkyl optionally substituted with COOR7, SO3−, or OH; where R7 is hereinbefore defined; and at least one of groups R1, R2, R3 and R4 comprises at least one N02 group. Also provided are methods for screening for a test agent whose effect upon nitroreductase enzyme activity and nitroreductase gene expression is to be determined.
Owner:GE HEALTHCARE LTD
Boric acid fluorescence molecular probe as well as preparation method and application thereof
ActiveCN104277061ASatisfy the detection requirements of neutral pHHigh detection sensitivityMaterial analysis by optical meansGroup 3/13 element organic compoundsFluoProbesBoronic acid
The invention discloses a boric acid fluorescence molecular probe as well as a preparation method and an application thereof, belonging to the technical field of fine chemical engineering. The probe compounds are formed by performing simple chemical modification on bodipy fluorescent dyes. Boric acid groups in the bodipy-based fluorescent dye molecules can be firmly combined with analyte by virtue of a covalent bond, so that a problem that the common fluorescence probe cannot be used in an aqueous liquid is solved, and guiding significance is provided for designing fluorescence-enhanced type probe compounds which can be practically applied. Excitation wavelength and emission wavelength of the probe compounds are in a visible region; in a practical detecting range with a nearly neutral pH value, the boric acid fluorescence molecular probe has good selectivity on glucose, gluconic acid, tartaric acid and the like, and has good sensitivity. The probe compounds can be used for detecting glucose in a fluorescence manner, and have a potential application value in glucose detection in the processes such as medical production and industrial production.
Owner:苏州高德瑞仪器有限公司
Nanogold shell coated upconversion nanocrystal composite structure material and preparation method thereof
InactiveCN108165270ASmall particlesMorphological rulesNanoopticsLuminescent compositionsBiological tissueBiocompatibility Testing
The invention belongs to the technical field of luminous materials and relates to a nanogold shell coated upconversion nanocrystal composite structure material and a preparation method of the material. The material solves the technical problems of large nano particle size, low fluorescence intensity, incomplete core-shell structure and poor biological tissue penetration capacity of the existing rare-earth upconversion luminescent material. The invention provides the nanogold shell coated upconversion nanocrystal composite structure material in a fluoride and oxide upconversion nano core-shellstructure. The invention further provides the preparation method of the composite structure material. Compared with the upconversion luminescent material prepared by the traditional method, the nanogold shell coated upconversion nanocrystal composite structure material is small in particle size, regular in pattern, good in dispersity, good in biocompatibility, and easy in surface biological functionalization; a gold shell is ultrathin, complete and consecutive; and selectively reinforced fluorescence emission is obtained by adjusting a position of an SPR (surface plasmon resonance) absorptionpeak. The preparation method of the material has the advantages of good controllability, low reaction temperature, low equipment requirements, simple in-situ synthesis operation technology and the like.
Owner:CHANGCHUN UNIV OF TECH
Erbium ion doped intermediate infrared luminous fluorine tellurate glass
InactiveCN103030275AEnhanced fluorescence emissionImprove thermal stabilityFluorescenceHeat stability
The invention provides an erbium ion doped intermediate infrared luminous fluorine tellurate glass. In terms of mol percentage, the glass comprises the following components by mole percent: 43-53 % of ZrF4, 18-22 % of CaF2, 3-5 % of YF3, 2-4 % of AlF3, 18-22 % of NaF, 0-5 % of TeO2, 0-5 % of GeO2, 0-5 % of Bi2O3 and 2-8 % of ErF3. The glass is prepared by using a covered platinum crucible and a silicon carbide rod electric furnace melting method. According to the invention, after heavy metal oxide is introduced, a fluoride glass is still transparent without crystallization, the infrared transmission rate of the glass is 85 % near intermediate infrared 2.7 microns, the heat stability of the glass is improved and the chemical stability of the glass is also improved; under laser diode pumping with wavelength of 980 nm, obviously enhanced intermediate infrared 2.7 microns fluorescence can be obtained; and the erbium ion doped intermediate infrared luminous fluorine tellurate glass provided by the invention is suitable for preparing and using erbium ion doped special glass and optical fiber materials which are luminous at intermediate infrared wave band of 2.7 microns.
Owner:SHANGHAI INST OF OPTICS & FINE MECHANICS CHINESE ACAD OF SCI
Nucleotide analogues
InactiveUS20050164182A1Enhanced fluorescence emissionSugar derivativesMicrobiological testing/measurementPolymerase LHydrolase
The invention relates to nucleosides comprising a reporter moiety which also functions to limit polymerase activity, characterised in that the reporter moiety is attached to the nucleoside through a linkage group cleavable by a hydrolase enzyme wherein the hydrolase enzyme is selected from the group consisting of esterases, phosphatases, peptidases, penicillin amidases, glycosidases and phosphorylases.
Owner:GE HEALTHCARE LTD
Novel near-infrared high-quantum-yield dye as well as preparation and application thereof
ActiveCN107141840AReduce the incubation concentrationPrecise positioningOrganic chemistryBenzoxanthene dyesQuantum yieldHalogen
The invention discloses a novel near-infrared high-quantum-yield dye which has the following structural formula I shown as the original specification, wherein R1, R2, R6 and R7 are hydrogen, a low-level alkyl, an ether group and a substituted alkyl or acyl that are independent respectively; R3, R4, R5, R8, R9 and R10 are hydrogen, a low-level alkyl or halogen that are independent respectively; R11 is hydrogen, methyl, a cyano group or trifluoromethyl; X<theta> is a negative ion. The invention discloses a preparation method of the dye. The dye has good biocompatibility, low toxicity, longer fluorescence-emission and high fluorescence quantum yield, the autofluorescence of a background is avoided, a fluorescence image with high signal-to-noise ratio can be obtained, and the dye is used for fluorescence labeling for nucleolar RNA in a biological system and plays an important pole in a study process of physiology related to the nucleolar RNA.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Mg-Yb-Er doped lithium niobate laser crystals and preparation method thereof
InactiveCN102797038AIncreased photorefractive change thresholdStrong energy transfer efficiencyPolycrystalline material growthBy pulling from meltMiddle infraredAll solid state
The invention discloses a Mg-Yb-Er doped lithium niobate laser crystals and a preparation method thereof, belonging to the field of single crystal growth. The laser crystals grow by Czochralski method, and the initial raw materials in the crystal growth formula comprise MgO, Yb2O3, Er2O3, Li2CO3 and Nb2O5 powder. The preparation method comprises the following steps: firstly preparing raw materials, mixing, and pressing, then sintering the block material, and then putting the sintered material in a lifting furnace to grow, and dissolving materials, sowing, seeding, necking, shouldering, conducting diameter growth, pulling out and annealing in the growth, and finally polarizing the grown crystals. The grown Mg-Yb-Er doped lithium niobate laser crystals disclosed herein have long fluorescent lifetime, large absorption and emission cross section, and are expected to be applied in all solid-state middle-infrared band lasers.
Owner:SHANGHAI INST OF OPTICS & FINE MECHANICS CHINESE ACAD OF SCI
Crystal material, preparation method thereof and application as laser crystal
InactiveCN107419334AEnhanced fluorescence emissionSolution to short lifePolycrystalline material growthBy pulling from meltTetragonal crystal systemSpace group
The invention discloses a crystal material, which is characterized in that the chemical formula of the crystal material is CaNdxEryLa(1-x-y)Ga3O7, wherein x is greater than or equal to 0.01 and less than or equal to 0.05, and y is greater than or equal to 0.1 and less than or equal to 0.3; the crystal material belongs to a tetragonal system and a space group shown in the description; the crystal material is formed into a laminated electronegative skeleton structure formed by a GaO4 tetrahedron, and Nd<3+>, Er<3+>, Ca2<+> and La<3+> are distributed among layers and have an unordered crystal structure. An Nd<+> ion is doped in Er<+3> activated CaLaGa3O7 crystal to greatly enhance the adsorption efficiency of the crystal for pump light, the efficient laser output of the -2.7mu m waveband of LD pumping is realized, the fluorescence emission of the crystal in an intermediate infrared waveband is enhanced, the service life and the particle number of 4I13 / 2 are greatly decreased, a self-final state bottleneck effect is inhibited, high gain is kept by laser media in an oscillation process, and the slope efficiency of the laser output is improved.
Owner:FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
Benzoate compound and synthesis method and application thereof
ActiveCN106632290ANo pollution in the processSimple reaction conditionsOrganic chemistryChemical recyclingFluorescenceSynthesis methods
The invention discloses a benzoate compound and a synthesis method and application thereof. The benzoate compound refers to a 4-(3-(5'-((trans)-substituent imine)methyl)-2-thienyl)-9- carbazolyl)benzoate compound. The synthesis method and application include firstly, synthesizing a target product from 4-(9-carbazolyl)benzoate; secondly, establishing a method for fluorescent recognition and detection of heavy metal ions by the target product. The synthesis method has the advantages that the synthesis method is simple, mild in synthesis condition and high in yield; the target product is enhanced in fluorescence under the action of the heavy metal ions and can be used for selectively recognizing and monitoring different heavy metal ions by selecting different substituents, thereby being high in sensitivity; the target product is reusable and recyclable, so that secondary pollution to the environment due to heavy metal detection reagents is reduced.
Owner:HUAIYIN TEACHERS COLLEGE
Two-dimensional cadmium coordination polymer with conjugated pi bond-containing aromatic carboxylic acid 3-quinolinedicarboxylic acid ligands and synthesis method for two-dimensional cadmium coordination polymer
InactiveCN103833779AEnhanced π*→π fluorescence emissionImprove rigidityLuminescent compositionsCadmium organic compoundsSynthesis methodsFluorescence
The invention discloses a two-dimensional cadmium coordination polymer with conjugated pi bond-containing aromatic carboxylic acid 3-quinolinedicarboxylic acid ligands and a synthesis method for the two-dimensional cadmium coordination polymer, relates to a synthesis method for a two-dimensional cadmium coordination polymer, and aims to solve the technical problems of high synthesis cost, poor monochromaticity and short fluorescence lifetime of a conventional blue-fluorescence organic luminous material. The molecular formula of the two-dimensional cadmium coordination polymer with the conjugated pi bond-containing aromatic carboxylic acid 3-quinolinedicarboxylic acid ligands is [Cd(C10H6NO2)2]n. According to the synthesis method, a hydrothermal synthesis method is used for preparing the two-dimensional cadmium coordination polymer from the conjugated pi bond-containing aromatic carboxylic acid 3-quinolinedicarboxylic acid ligands and cadmium nitrate tetrahydrate. The two-dimensional cadmium coordination polymer can be determined to be clearly blue-fluorescent from a CIE chromaticity diagram, is pure in color and high in monochromaticity, and can be used as a metal organic blue luminous material. The two-dimensional cadmium coordination polymer and the synthesis method are applied to the field of preparation of organic luminous materials.
Owner:HARBIN INST OF TECH
Erbium-doped mid-infrared luminescent zirconium fluoride zinc-based glass and preparation method thereof
ActiveCN105271727ATransparent optical quality is goodEnhanced fluorescence emissionGlass shaping apparatusFluorescenceErbium doping
The invention discloses erbium-doped mid-infrared luminescent zirconium zinc-based fluoride glass. Zirconium zinc-based glass which is transparent and better in optical quality is obtained by introducing ZnF2 into erbium-doped mid-infrared luminescent fluorozirconate ZBYAN glass, the infrared transmittance of the zirconium zinc-based glass is kept at a higher level near mid-infrared 2.7 microns, fluorescence emission which is obviously enhanced at mid-infrared 2.7 microns can be obtained under pumping of a laser diode with 980 nm wavelength, and a preparation method is suitable for preparation and application of mid-infrared 2.7 micron laser glass and optical fiber materials.
Owner:CHINA JILIANG UNIV
Assays for pathogen detection using microwaves for lysing and accelerating metal-enhanced fluorescence
ActiveUS20140030700A1High sensitivityLow powerBioreactor/fermenter combinationsBiological substance pretreatmentsMicroorganismAssay
The present invention relates to an assay for the determination of a microorganism including a lysing chamber having triangular shaped metallic structures wherein the apexes of two triangles are arranged in alignment and forming a reactive zone for placement of the microorganism and lysing by microwave energy for exposing and isolating a target polynucleotide sequence. The isolated target polynucleotide sequence is introduced to an assay system for contact with polynucleotides which are complimentary to the isolated target polynucleotide sequence. Fluorophore-labeled capture polynucleotides are added for hybridizing to any bound target polynucleotide. Bound target polynucleotides are detected by metal enhanced fluorescence.
Owner:UNIV OF MARYLAND BALTIMORE COUNTY
Quantum-dot spectrometers for use in biomedical devices and methods of use
InactiveUS20170086676A1High fluorescence emissionAccurately detectNon-optical adjunctsDiagnostics using spectroscopyPhysicsBiomedical equipment
Device and methods for the incorporation of Quantum-Dots for spectroscopic analysis into biomedical devices are described. In some examples, the Quantum-Dots act as light emitters, light filters or analyte specific dyes. In some examples, a field of use for the apparatus and methods may include any biomedical device or product that benefits from spectroscopic analysis.
Owner:JOHNSON & JOHNSON VISION CARE INC
Lanthanide Complexes as Fluorescent Indicators for Neutral Sugars and Cancer Diagnosis
InactiveUS20100291689A1Enhanced fluorescence emissionSmaller ionic radiusIsocyanic acid derivatives preparationOrganic compound preparationFluorescenceCancers diagnosis
A group of water-soluble salophene-lanthanide complexes and other salophene-metal complexes are useful for purposes including: (i) detecting neutral carbohydrates at physiologically-relevant pH, (ii) the selective detection of gangliosides, and (iii) the selective detection of lysophosphatidic acid (LPA) in the presence of phosphatidic acid. The selective detection of LPA is useful in diagnosing ovarian and other cancers.
Owner:BOARD OF SUPERVISORS OF LOUISIANA STATE UNIV & AGRI & MECHANICAL COLLEGE +1
Amino-substituted BF2-chelated azadipyrromethene near-infrared pH fluorescent probe and preparation method and application thereof
InactiveCN107602600ALow pH Response RangeFew reportsMaterial analysis by observing effect on chemical indicatorGroup 3/13 element organic compoundsInfraredHydrogen
The invention discloses an amino-substituted BF2-chelated azadipyrromethene (aza-BODIPY) near-infrared compound. The compound has a structure shown in the description. Compared with the prior art, theamino-substituted BF2-chelated azadipyrromethene near-infrared compound has the following obvious advantages: the p-N,N-diethyl-substituted BF2-chelated azadipyrromethene near-infrared compound is synthesized for the first time, introduction of an amino group can make the absorption spectrum of BF2-chelated azadipyrromethene generate a significant red shift, and therefore application in biological aspects is facilitated. After the photosensitizer is protonated by hydrogen ions, the ultraviolet absorption spectrum changes significantly, the color of the solution is changed from purple to blue,meanwhile a photoinduced process is selectively reduced, and the fluorescence emission is reinforced, therefore the compound NEt2-aza-BODIPY has an application of high-selectivity naked-eye color recognition on hydrogen ions and fluorescent recognition. The invention discloses a preparation method of the amino-substituted BF2-chelated azadipyrromethene near-infrared compound.
Owner:PINGDINGSHAN UNIVERSITY
Fiber-optic biosensor and biosensing methods
InactiveUS20140030150A1Good senseShorten detection timeComponent separationFluorescence/phosphorescenceMolecular TransportMicrofluidic channel
A biosensor device that includes a module defining at least one microfluidic channel, an optical waveguide exposed along at least a portion of its length to fluid flow within the microfluidic channel, where a surface of the optical waveguide being prepared to bind a target biomarker, and an excitation source to couple an excitation wavelength of light into the optical waveguide. The device also includes a sensor for detecting emission light from the optical waveguide at an emission wavelength characteristic of binding of the target biomarker. Particular devices include multiple waveguides in multiple microfluidic channels. Particular devices include microfluidic channels with serpentine bump structures that aid molecular transport.
Owner:UNIV OF LOUISVILLE RES FOUND INC
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