49 results about "Carbohydrazide" patented technology

The invention discloses a colorectal cancer radiotherapy sensitization medicine and application thereof, belongs to the field of biological medicine, and particularly relates to a colorectal cancer radiotherapy sensitization medicine which comprises active pharmaceutical ingredients and a solvent, the active pharmaceutical ingredients comprise doxorubicin and a nitrogen-containing compound, the nitrogen-containing compound comprises quinoline-6-carbohydrazide and N-benzyloxymethyl-4-nitroimidazole, and the nitrogen-containing compound comprises quinoline-6-carbohydrazide and The colorectal cancer radiotherapy sensitization medicine disclosed by the invention focuses on a key driving gene FOXP4 for colorectal cancer radiotherapy resistance, and FOXP4 protein is degraded through a ubiquitin-proteasome way, so that not only can the sensitivity of tumor cells to radiotherapy be remarkably improved and tumor growth be inhibited, but also damage to normal tissues is reduced; moreover, the problem of drug resistance easily generated by a traditional method is effectively avoided, the research and development cost is greatly reduced, clinical transformation is accelerated, and the method has a good clinical application prospect.

There are provided a processing solution containing an alkali compound, water, and a corrosion inhibitor, in which the amount of dissolved oxygen one week after the preparation of the processing solution is 0.2 mg / L or more and 1.5 mg / L or less, and the corrosion inhibitor is at least one selected from the group consisting of N,N-diethylhydroxylamine, 1-thioglycerol, 1-amino-4-methylpiperazine, carbohydrazide, methylethylketoxime, erythorbic acid, and salts thereof, a method for manufacturing the processing solution, and a method for processing a substrate and a method for manufacturing a semiconductor device using the processing solution.

This invention relates to a near-infrared low-potential electrochemiluminescence dual-ligand stabilized gold nanoclusters, their preparation method, and applications. The method uses chloroauric acid as the gold source and thiomalic acid and sodium citrate as reducing and stabilizing agents, respectively, in a two-step synthesis. First, Au is reduced online using thiomalic acid. 3+ Water-soluble gold nanoclusters were prepared using a novel method. These nanoclusters were then incubated with sodium citrate, and based on the ligand exchange principle, gold nanoclusters co-coated with thiomalic acid and sodium citrate were synthesized. The raw materials required for this invention are readily available and all possess good water solubility. The synthesis apparatus is simple, the conditions are mild, and the operation is safe. The resulting dual-ligand-coated gold nanoclusters exhibit good stability and produce low-potential near-infrared electrochemiluminescence in the long-wavelength region in an aqueous system. This overcomes the limitation of most current electrochemiluminescent materials requiring hydrazine hydrate or carbazide as a co-reactant. Using a non-toxic tert-butylamine-borane co-reactant, low-potential electrochemiluminescence radiation of 0.57V in the near-infrared region was generated.

The utility model provides an electronic detonator for seismic exploration, which comprises a wire clamp, a conducting wire arranged below the wire clamp, a basic detonator arranged below the conducting wire, and the basic detonator consists of a shell, an initiating explosive, a transition explosive, a high explosive combination and a reinforcing cap. According to the electronic detonator for seismic exploration, the lead, the delay control module, the ignition powder, the initiating explosive, the transition explosive, the high explosive and other structures are arranged, the lead is made of pure copper, so that good conductivity is ensured, the initiation time is accurately controlled through the delay control module, and the delay precision of the detonator is improved; the trinitroresorcinol lead and the lead thiocyanate in a certain proportion are used as ignition powder, the hexogen is used as a high explosive, the Teramine is used as a transition explosive, and the perchloric acid tricarbohydrazide zinc is used as primary explosive, so that the requirements on the safety, the delay precision and the power capability of the detonator in the seismic exploration process are met; reliable application of the electronic detonator in seismic exploration is realized, and a powerful guarantee is provided for obtaining high-quality seismic exploration data.

The invention discloses a preparation method of a novel boiler deoxidant, and belongs to the technical field of chemical synthesis. The invention provides a preparation method of a novel boiler deoxidant, which comprises the following steps of: dehydrating isochromanone serving as a raw material and hydroxylamine sulfate in a solvent (water, ethanol or methanol) under an acidic condition to generate isochromanone oxime, and mixing the isochromanone oxime with other oximes, a dispersing agent and the like in parts by weight to prepare the required boiler deoxidant. The deoxidant is prepared from 3 to 5 parts of isochroman ketoxime, 12 to 16 parts of acetoxime, 12 to 14 parts of acetaldoxime, 8 to 12 parts of carbohydrazide, 4 to 7 parts of a dispersant, 5 to 10 parts of a pH regulator, 5 to 10 parts of a catalyst and 40 to 50 parts of water, wherein the other raw materials are prepared from 3 to 5 parts of isochroman ketoxime, 12 to 16 parts of acetoxime, 12 to 14 parts of acetaldoxime, 8 to 12 parts of carbohydrazide, 4 to 7 parts of a dispersant, 5 to 10 parts of a pH regulator, 5 to 10 parts of a catalyst and 40 to 50 parts of water. According to the preparation method, boiler pipelines, equipment and the like can be passivated while low toxicity, high efficiency and high speed can be guaranteed, equipment corrosion damage caused by metal oxide deposition of a boiler is prevented, and the product is non-toxic, harmless and mild to the environment.

The present application relates to a kind of water-soluble carbohydrazide derivative and its preparation method, the method for detecting ion or amino acid, belong to organic small molecule probe technical field.The present application introduces different pyridyl on the hydrazine group of carbohydrazide, obtains a kind of pyridyl substituted carbohydrazide derivative.Compared with existing carbohydrazide compound, the recognition function of pyridyl substituted carbohydrazide derivative provided by the present application has been expanded and regulated, can be used for Cu 2+ , Hg 2+ , Ca 2+ , Cd 2+ , Zn 2+ , AcO ‑ , HSO4 ‑ And glutamic acid (Glu) / L-Asp, lysine (Lys) / arginine (Arg) recognition detection.The water-soluble carbohydrazide derivative provided by the present application as molecular probe, its structure is stable, synthesis method is simple, has the ability of responding to multiple substrates, and water-soluble, has wide application prospect.

This invention discloses a method for synthesizing N-(2-oxopropyl)-bis(3-pyridylmethylene)carbonyldihydrazone. This method synthesizes N-(2-oxopropyl)-bis(3-pyridylmethylene)carbonyldihydrazone by reacting carbohydrazide, pyridine-3-carboxaldehyde, and 1-chloroacetone. This method has the advantages of high yield, simple process, low cost, good product quality, and ease of large-scale production, making it worthy of widespread use.

The present invention discloses a colorectal cancer radiotherapy sensitizing drug and its application, belonging to the field of biomedicine, and specifically relates to a colorectal cancer radiotherapy sensitizing drug, comprising a pharmaceutical active ingredient and a solvent, wherein the pharmaceutical active ingredient comprises doxorubicin and a nitrogen-containing compound, wherein the nitrogen-containing compound comprises quinoline-6-carbohydrazide and N-benzyloxymethyl-4-nitroimidazole. The colorectal cancer radiotherapy sensitizing drug disclosed in the present invention focuses on FOXP4, a key driver gene of colorectal cancer radiotherapy resistance, and degrades FOXP4 protein through the ubiquitin-proteasome pathway. This not only significantly increases the sensitivity of tumor cells to radiotherapy, inhibits tumor growth, and reduces damage to normal tissues; it also effectively circumvents the drug resistance problem that is prone to occur with traditional methods, significantly reduces R&D costs, accelerates clinical transformation, and has good clinical application prospects.

The invention discloses a formononetin derivative containing piperidine-4-carbohydrazide as well as a preparation method and application of the formononetin derivative, and belongs to the technical field of pesticide synthesis. According to the invention, a piperidine-4-carbohydrazide group with excellent activity is introduced into the structure of formononetin, a series of formononetin derivatives of piperidine-4-carbohydrazide are synthesized, and the activity of the synthesized formononetin derivatives containing piperidine-4-carbohydrazide in inhibiting plant pathogens is tested. It is found that the formononetin derivative of piperidine-4-carbohydrazide synthesized by the invention can effectively inhibit plant pathogenic fungi, especially rhizoctonia solani.

The invention relates to the field of neutralizing hydrogen sulphide and light mercaptans in oil industry fluids using chemical neutralizing reagents and is applicable in the oil and gas industry for cleaning and neutralizing oil transport tanks, pipelines, heat exchangers, fractionating and distillation columns, reactors, filters, settling tanks, gas scrubbers, air coolers, temporary storage tanks and any other receptacles and piping used in oil and gas processing. The proposed hydrogen sulphide scavenger for light and volatile petroleum products contains 95% ethyl alcohol solution, carbohydrazide, grade A 25% ammonia solution, GD anti-foaming agent, 3% hydrogen peroxide solution, concentrated soap (pH=14) and demineralized water in a given ratio of components. The present invention provides a composition that reduces or eliminates the presence of hydrogen sulphide in various fluids.

The present invention addresses the problem of providing a method for producing 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide with high safety and high yield. The present invention relates to a method for producing 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide or a salt thereof via 3-methyl-1, 2, 4-thiadiazole-5-carboxamide or a salt thereof without the use of toxic carbon monoxide, and more particularly, to a method for producing 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide or a salt thereof via 3-methyl-1, 2, 4-thiadiazole-5-carboxamide or a salt thereof. According to the present invention, it is possible to provide a safe and high-yield method for producing 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide, which is an important synthetic intermediate for non-azonetin, which is useful as a drug for the treatment of sex hormone-dependent diseases.

The present invention relates to the technical field of compound synthesis, and in particular to an efficient synthesis method of carbohydrazide, comprising the following steps: (1) preparing a urea aqueous solution, a sodium nitrite aqueous solution, an acid solution, and an alkali solution; (2) simultaneously pumping the urea aqueous solution and the sodium nitrite aqueous solution into a microchannel reactor to mix them uniformly, and then pumping the acid solution into the reactor to carry out a diazotization reaction, wherein the diazotization reaction temperature is lower than 10°C and the reaction residence time is within 5 seconds; (3) then pumping the alkali solution into the reactor below 0°C to make the pH value of the reaction solution alkaline and continuing the reaction in the microchannel reactor, wherein the reaction residence time is within 5 seconds, and collecting a diazonium salt intermediate solution; and (4) adding an alcohol solvent into the diazonium salt intermediate solution, stirring the solution uniformly, adding a metal catalyst, and then introducing hydrogen into the reactor to carry out a hydrogenation catalytic reduction reaction to obtain a crude carbohydrazide product, which is then refined to obtain a pure carbohydrazide product with a yield of more than 90%. The present invention can realize the process of urea diazotization and forming a relatively stable diazonium salt intermediate.

The invention discloses a synthesis method of N-(2-oxopropyl)-bis (3-pyridine methylene) carbonyl dihydrazone, and relates to the field of chemical engineering. According to the invention, N-(2-oxopropyl)-bis (3-pyridylmethylene) carbonyl dihydrazone is synthesized through a reaction of carbonyl dihydrazone, pyridine-3-formaldehyde and 1-chloroacetone, and then N-(2-oxopropyl)-bis (3-pyridylmethylene) carbonyl dihydrazone is synthesized. The synthesis method disclosed by the invention has the advantages of high yield, simple process route, low cost, good product quality, easiness in large-scale production and the like, and is worthy of popularization and application.

The present invention aims to provide a method for producing 3-methyl-1,2,4-thiadiazole-5-carbohydrazide safely and in high yield. The present invention relates to a method for producing 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or a salt thereof, via a compound represented by the formula (2):wherein R is a C1-4 alkyl group, which is a novel compound, or a salt thereof. According to the present invention, a safe and high-yielding production method of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide, which is an important synthetic intermediate for fezolinetant useful as a medicament for the treatment of sex hormone-dependent diseases, can be provided.

The invention belongs to the technical field of high-performance polyurethane elastomers, and discloses a super-strong and super-tough thermosetting polyurethane elastomer capable of being self-repaired and recycled as well as a preparation method and application of the super-strong and super-tough thermosetting polyurethane elastomer. Polycaprolactone is used as a soft segment, 4, 4 '-dicyclohexylmethane diisocyanate is used as a hard segment, dibutyltin dilaurate is used as a catalyst, oxalyl dihydrazine and carbohydrazide are used as chain extenders, and 3-aminophenylboronic acid is used for blocking, so that a polyurethane straight chain is generated through reaction; and carrying out vacuum drying and dehydration to obtain the super-strong and super-tough thermosetting polyurethane elastomer which has boric acid ester bonds and can be self-repaired and recycled. The polyurethane elastomer forms a double dynamic network of hydrogen bonds and boric acid ester bonds, dissociation and recombination under thermal stimulation can be achieved, and the self-repairing performance of the elastomer is achieved. Meanwhile, strong multiple hydrogen bond interaction is formed between the two hydrazide chain extenders, so that a sample is endowed with excellent energy dissipation capability, and excellent mechanical properties are achieved.

The invention relates to a zinc ion detection fluorescent probe as well as a preparation method and application thereof, and particularly provides an indole compound N '-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-yl) methylene)-1H-indole-2-carbohydrazide which can be used as a zinc ion detection fluorescent probe and can be used for detecting zinc ions. High sensitivity and high selectivity are shown on Zn < 2 + > in a solution.

This invention discloses a method for preparing a ternary dynamic glycopeptide hydrogel bio-ink, comprising the following steps: dissolving methacrylamide gelatin, aldehyde-modified hyaluronic acid, hydrazide-modified gelatin, and a photoinitiator together in a solvent and mixing them evenly to obtain the bio-ink. This bio-ink constructs a dynamic covalent cross-linking network through reversible acylhydrazone bonds formed between aldehyde-modified hyaluronic acid and hydrazide-modified gelatin, providing a remodelable three-dimensional microenvironment for cells. Simultaneously, the photocrosslinking properties of methacrylic anhydride-modified gelatin are introduced to rapidly solidify and maintain overall shape stability during the printing stage, providing a remodelable cellular microenvironment during subsequent in vitro culture. This establishes an organoid culture platform with both good printability and excellent cell compatibility, providing a reliable material basis for subsequent drug screening and functional studies.

The invention relates to the technical field of chemical synthesis, in particular to a tetranuclear dysprosium-based metal-organic framework material and a preparation method and application thereof. A chemical formula of the tetranuclear dysprosium-based metal-organic framework material is [Dy4 (dbm) 2 (H2L1) 2 (HL2) 2 (CH3O) 2]. 6CH3OH, H4L1 is N '2, N' 6-bis ((E)-3, 5-di-tert-butyl-2-hydroxybenzylidene) pyridine-2, 6-dicarbohydrazide, H3L2 is (E)-N '-(3, 5-di-tert-butyl-2-hydroxybenzylidene)-6-(hydroxymethyl) pyridine hydrazide, and Hdbm is dibenzoylmethane; the tetranuclear dysprosium-based metal-organic framework material crystal belongs to a monoclinic system and a C2 / c space group. The preparation method of the chiral phosphine nickel (II) complex is simple and convenient to operate, high in purity and good in reproducibility. The tetranuclear dysprosium-based metal-organic framework material disclosed by the invention is good in thermal stability, shows good catalytic performance in a cycloaddition reaction for synthesizing cyclic carbonate through CO2 catalytic conversion, and has a good application prospect.

The application discloses a steam enhanced SNCR system and a use method thereof, relates to the technical field of flue gas denitration treatment, and comprises the following steps: S1, a first conveying control unit is used for conveying main steam to a coupling mixer and controlling the flow of the main steam; S2, a second conveying control unit is used for conveying ammonia water and controlling the flow of the ammonia water; S3, a coupling processing unit is used for mixing the main steam and the ammonia water to form a mixture; S4, the second conveying control unit is used for conveying an efficiency improver and controlling the flow of the efficiency improver, and the coupling processing unit is used for mixing the main steam and the ammonia water mixture with the efficiency improver to form a target mixture in a superheated state; and S5, the coupling mixer is used for conveying the target mixture into a lance, and the lance is used for spraying the target mixture into an incinerator. According to the application, water is not added to dilute the ammonia water, and the steam consumption is greatly reduced; the medium-temperature and medium-pressure steam is used to replace the medium-temperature and high-pressure steam in other schemes, so that the requirement for steam quality is reduced; and when the oxygen content is too high, a hydrazine carbohydrazide solution is started to enhance the denitration reaction efficiency.

The application relates to the technical field of water treatment agents, and discloses a biomass source-containing boiler water treatment agent and a preparation method thereof, the biomass source-containing boiler water treatment agent is prepared from the following raw materials in mass percentage: secondary desalted water 60-70%, ammonia water 10-20%, 5-10% modified humic acid, 1-5% cashew phenol-based corrosion inhibitor and 5-10% carbohydrazide oxygen scavenger. The modified humic acid and the cashew phenol-based corrosion inhibitor are prepared, the two can synergistically improve the scale inhibition effect and the corrosion inhibition effect of the boiler water treatment agent, and the application has a wide application prospect in the field of industrial boiler treatment.

The invention relates to an Al < 3 + > fluorescence sensor based on 1, 2, 3-triazole-Schiff base as well as preparation and application. The structure of the fluorescent sensor is as follows: step 1, synthesis of 5-methyl-2H-1, 2, 3-triazole-4-ethyl formate, step 2, synthesis of 5-methyl-2-phenyl-1, 2, 3-triazole-4-ethyl formate, step 3, synthesis of 5-methyl-2-phenyl-1, 2, 3-triazole-4-formylhydrazine, step 4, synthesis of 5-methyl-2-phenyl-1, 2, 3-triazole-4-formylhydrazine, step 5, synthesis of 5-methyl-2-phenyl-1, 2, 3-triazole-4-formylhydrazine, step 5, synthesis of 5-methyl-2-phenyl-1, 2, 3-triazole-4-formylhydrazine, step 5, synthesis of 5-methyl-2- and step 4, synthesis of (E)-N '-(2-hydroxynaphthalene-1-methylene)-5-methyl-2-phenyl-2H-1, 2, 3-triazole-4-carbohydrazide (G3) is carried out, and the synthesis of the (E)-N'-(2-hydroxynaphthalene-1-methylene)-5-methyl-2-phenyl-2H-1, 2, 3- The fluorescent sensor ((E)-N '-(2-hydroxynaphthalene-1-methylene)-5-methyl-2-phenyl-2H-1, 2, 3-triazole-4-carbohydrazide) is used for detecting aluminum ions, is excellent in performance, high in anti-interference capability, good in selectivity, high in sensitivity, short in response time and low in toxicity, and can be applied to actual water samples.

The present invention addresses the problem of providing a method for producing 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide with high safety and high yield. The present invention relates to a method for producing 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide or a salt thereof via a compound represented by formula (2) (in the formula, R represents a C1-4 alkyl group) or a salt thereof, which is a novel compound. According to the present invention, it is possible to provide a safe and high-yield method for producing 3-methyl-1, 2, 4-thiadiazole-5-carbohydrazide, which is an important synthetic intermediate for non-azonetin, which is useful as a drug for the treatment of sex hormone-dependent diseases.

The invention discloses a benzothiazole acylhydrazone zinc ion fluorescent probe as well as a preparation method and application thereof. The probe can overcome the defects of complex synthesis, low sensitivity, long response time and the like of an existing fluorescent probe for detecting zinc ions. The preparation method of the probe comprises the following steps: introducing an acylhydrazone group containing oxygen and nitrogen into a 2 # site of benzothiazole to synthesize 1, 3-benzothiazole-2-carbohydrazide, and carrying out condensation reaction on the 1, 3-benzothiazole-2-carbohydrazide and 1-hydroxy-2-naphthaldehyde under a liquid phase condition to prepare the probe. The benzothiazole acylhydrazone zinc ion fluorescent probe prepared by the invention can identify zinc ions by naked eyes in a DMSO / HEPES buffer solution (V: V = 9: 1, the concentration of the HEPES buffer solution is 10 mmol / L, and the pH value is 7.4) solution, a 1: 1 complex is formed, and the response time is about 6 s. Meanwhile, the probe shows better selectivity and stronger anti-interference capability in the process of detecting the zinc ions, and the detection limit is 9.8 * 10 <-9 > mol / L. The pH is in a range of 4-12, the probe has good detection performance on zinc ions, and trace detection of the zinc ions in a water sample can be realized in actual environmental application.

The invention relates to a synthesis method of a compound (IV-2): # imgabs0. The method has the advantage that the purity of the generated isotope is very satisfactory. These compounds are key intermediates for the synthesis of pharmaceutical compounds, in particular non-azolintams and deuterated non-azolintams.

The invention provides anti-aging gel as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. Enabling tetrahydrogeraniol to react with succinic acid and cell penetrating peptide in sequence to prepare a penetration enhancer; the preparation method comprises the following steps: reacting hyaluronic acid with an oxidizing agent to prepare oxidized hyaluronic acid; the preparation method comprises the following steps: reacting carboxyethyl chitosan with carbohydrazide to prepare carbohydrazide modified carboxyethyl chitosan; the preparation method comprises the following steps: embedding notoginsenoside, resveratrol, vitamin E and coenzyme Q10 through lipidosome to prepare active lipidosome; dissolving carbohydrazide modified carboxyethyl chitosan in water, adding a penetration enhancer and active lipidosome, uniformly mixing, then adding an oxidized hyaluronic acid aqueous solution, and stirring to form gel, thereby obtaining the anti-aging gel. The prepared anti-aging gel has good moisturizing, anti-aging, anti-oxidation and anti-inflammatory effects, tissue metabolism and repair are accelerated, and meanwhile, the anti-aging gel is good in stability, good in transdermal absorption effect, low in irritation and high in safety and has wide application prospects.

Provided are a treatment liquid which not only has excellent removability of a metal component and a residue to be removed but also has excellent anticorrosion properties for a metal containing a Cu atom, a method for producing a treatment liquid, a method for treating a substrate using the treatment liquid, and a method for manufacturing a semiconductor device.SOLUTION: Provided are a treatment liquid containing an alkali compound, water, and a corrosion inhibitor, in which the amount of oxygen dissolved after a lapse of one week from the preparation of the treatment liquid is 0. 2mg / L or more and 1. 5mg / L or less, and the corrosion inhibitor is at least one selected from the group consisting of N, N-diethylhydroxylamine, 1-thioglycerol, 1-amino-4-methylpiperazine, carbohydrazide, methyl ethyl ketoxime, erythorbic acid, and salts thereof, a method for producing a treatment liquid, and a method for treating a substrate and a method for manufacturing a semiconductor device using the treatment liquid.SELECTED DRAWING: None

The invention relates to the technical field of water treatment agents, and discloses a biomass-source-containing boiler water treatment agent and a preparation method thereof.The biomass-source-containing boiler water treatment agent is prepared from, by mass, 60%-70% of secondary demineralized water, 10%-20% of ammonia water, 5%-10% of modified humic acid, 1%-5% of a cardanol-based corrosion inhibitor and 5%-10% of a carbohydrazide deoxidant, by preparing the modified humic acid and the cardanol-based corrosion inhibitor, the scale inhibition effect and the corrosion inhibition effect of the boiler water treatment agent are synergistically improved, and the boiler water treatment agent has a wide application prospect in the field of industrial boiler treatment.

The invention is applicable in the oil and gas industry for cleaning and neutralizing oil transport tanks, pipelines, heat exchangers and other receptacles and piping. A hydrogen sulphide scavenger for neutralizing and cleaning gas lines contains demineralized water, ethyl alcohol, carbohydrazide, 25% ammonia solution, and concentrated soap having a pH=14. The invention makes it possible to more effectively neutralize and clean oil and gas processing equipment of residues of products of petrochemical operations.

The application discloses a hydrazide derivative-based carbon dot and a preparation method and application thereof, relates to the technical field of antibacterial materials, and discloses a preparation method, which comprises the following steps: taking a hydrazide derivative as raw material, and preparing a hydrazide derivative-based carbon dot through a one-step hydrothermal method; the hydrazide derivative is at least one of phenylhydrazine, methylhydrazine, isophthalic dihydrazide, thio-diacid hydrazide, salicylic hydrazide, acetic hydrazide, 3-pyridine carbohydrazide, benzhydrazine, p-carboxyphenylhydrazine and carbon hydrazide; the application also protects the hydrazide derivative-based carbon dot prepared through the above method and the application of the hydrazide derivative-based carbon dot in the preparation of antibacterial materials and antibacterial drug resistance materials. The application has the beneficial effect that 10 kinds of hydrazide derivative-based carbon dots are prepared through a simple one-step hydrothermal method with 10 kinds of hydrazide derivatives as precursors; the 10 kinds of hydrazide derivative-based carbon dots all have antibacterial activity, and the carbon hydrazide-based carbon dot shows excellent antibacterial activity and can effectively eradicate biofilms.