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Rare-earth cerium Schiff base complex and preparation method and application thereof

A technology of Schiff bases and complexes, which is applied in the field of rare earth cerium Schiff base complexes and their preparation, can solve the problems of increased insulin sensitivity, the incidence of cancer and the probability of obesity, etc., and achieve high yield, The effect of high product purity and convenient and simple preparation method

Inactive Publication Date: 2017-02-22
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Biochemical studies have shown that PTP1B knockout mice not only develop normally, but also have increased sensitivity to insulin, and the incidence of cancer and the probability of obesity have not increased

Method used

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  • Rare-earth cerium Schiff base complex and preparation method and application thereof
  • Rare-earth cerium Schiff base complex and preparation method and application thereof
  • Rare-earth cerium Schiff base complex and preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0021] Embodiment 1. Complex of the present invention [Ce(HL) 2 (NO 3 ) 3 ] preparation and crystal growth method.

[0022] Weigh 0.434g Ce(NO 3 ) 3 Dissolve in 2ml of methanol, 0.114g of N'-(pyridine-2-methylene)pyrazine-2-carbohydrazide in 50ml of methanol, put the above two solutions in the reactor and mix them, heat and reflux at 55°C for 8h, A dark green clear liquid was obtained, which was filtered, and light yellow massive crystals were precipitated in the filtrate. The collected crystals were washed three times with water and methanol respectively, and dried in vacuum, with a yield of 65%. Elemental analysis [Ce(C 11 h 9 N 5 O) 2 (NO 3 ) 3 ]·2CH 3 OH: Theoretical: C 33.53H 2.70N 22.03; Found: C 33.99, H 2.73, N 22.41.

Embodiment 2

[0023] Embodiment 2. Complexes of the present invention [Ce(HL) 2 (NO 3 ) 3 ]·2CH 3 OH single crystal X-ray diffraction test condition results.

[0024] Under a high-powered microscope, select regular, transparent yellow blocky single crystal particles. The selected crystals were glued firmly with glass filaments and fixed on a Bruker SMART 1000CCD surface-detecting diffractometer. With the graphite monochromator Mo-Kα as the radiation source, the collected samples have a wavelength of X-ray diffraction data. In the ω-scan mode, the diffraction data were corrected for LP factors and empirical absorption. After all the X-ray diffraction patterns were restored to diffraction index data, the crystal structure was solved by the direct method of SHELXL-97, hydrogen atoms were hydrogenated theoretically, and anisotropic refinement was performed, and finally the corresponding molecular structure diagram was drawn. Some other detailed information about the crystals is listed i...

Embodiment 3

[0028] Example 3. Complex [Ce(HL) 2 (NO 3 ) 3 ] Electrospray mass spectrum:

[0029] In order to study the existing form of the complex in solution, a small amount of solid powder of the complex was dissolved in methanol, centrifuged to obtain a clear and transparent solution, and the sample was loaded to the electrospray mass spectrometer, and the electrospray ion source was used to detect and record the data in the form of positive ions . figure 2 is the positive ion electrospray mass spectrum of the complex. Molecular ion peaks of the corresponding complexes can be observed in all spectra. Table 2 is the positive ion electrospray mass spectrum assignment of the complex. The results show that the experimental value is consistent with the theoretical value, and the complex exists in a stable form in the solution.

[0030] Table 2 Complexes [Ce(HL) 2 (NO 3 ) 3 ](1) positive ion electrospray mass spectrometry assignment

[0031]

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Abstract

The invention provides a rear-earth cerium Schiff base complex and a preparation method and application thereof. The molecular formula of the complex is [Ce(HL)2(NO3)3], wherein HL is N'-(pyridine-2-methylene)pyrazine-2-carbohydrazide. The preparation method of the complex comprises the steps that a methanol solution of rear earth cerium salt is dropwise added into a methanol solution placed in a ligand of a round-bottom flask, heating reflux is conducted at the temperature ranging from 40 DEG C to 60 DEG C for 6-9 h, deep green clear liquid is obtained, filtration is conducted, light yellow blocky crystals are dissolved out from a filtrate, and the yield is 45%-75% or above. The complex has a good inhibiting effect on the activity of protein tyrosine phosphatase (PTP1B and TCPTP) and can serve as an inhibitor of the protein tyrosine phosphatase (PTP1B and TCPTP) for use.

Description

technical field [0001] The invention relates to the field of metal complexes, in particular to a rare earth cerium Schiff base complex, a preparation method thereof, and an application of the complex as a PTP1B and TCPTP activity inhibitor. Background technique [0002] Protein tyrosine phosphatases (PTPs) are a class of metal-free enzymes that widely exist in organisms, and they cooperate with protein kinases to regulate the reversible dynamic process of protein tyrosine phosphorylation. Among them, protein tyrosine phosphorylates proteins, while protein kinases dephosphorylate proteins. PTPs can regulate the cell cycle and signal transduction. In response to cell signals, it can regulate the degree of protein tyrosine phosphorylation by combining with protein tyrosine kinases. Aberrant regulatory pathways of these signaling systems have been found to be associated with many diseases. Abnormal PTPs activity can lead to the occurrence of many diseases including cancer, dia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/00A61P3/04A61P3/10A61P35/00
CPCC07B2200/13C07F5/003
Inventor 卢丽萍杜然袁彩霞
Owner SHANXI UNIV
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