5676results about "Group 4/14 element organic compounds" patented technology

Disclosed is a nitrogen-containing heterocyclic compound, pharmaceutical composition thereof and application thereof. The present disclosure provides a nitrogen-containing heterocyclic compound of formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof. The nitrogen-containing heterocyclic compounds as represented in Formula I in the present disclosure have good inhibitory effects on cells of various mutations such as KRAS G12C, KRAS G12D, KRAS G12V, KRAS Q61H and other mutations, as well as on KRAS-amplified wild-type cells, and are expected to treat and / or prevent a wide range of diseases associated with Ras.

The invention discloses a self-assembled monomolecular layer hole transport material, a hole transport layer and a battery thereof. According to the present invention, the compound having different anchoring groups and represented by the formula (I) can be subjected to firm self-assembly with the substrate surface through the chemical bonding manner, such that the good coverage rate is provided, the film forming quality is increased, and the transmission performance is improved; and meanwhile, the material has a rigid conjugate large-plane condensed ring core structure, so that the hole transmission performance of the material is ensured, and the photovoltaic performance is favorably improved. When the material is applied to a perovskite solar cell to prepare a hole transport layer, the hole extraction capability can be enhanced, and the open-circuit voltage, the filling factor and the photoelectric conversion efficiency of a device can be improved.

An organic electroluminescence device is provided and including a first electrode, a hole transport region disposed on the first electrode, an emission layer disposed on the hole transport region, an electron transport region disposed on the emission layer, and a second electrode disposed on the electron transport region, wherein the emission layer may include an organometallic compound, thereby exhibiting high luminous efficiency and long service life characteristics.

A method for making a dense organosilicon film with improved mechanical properties includes the steps of: providing a substrate within a reaction chamber; introducing into the reaction chamber a gaseous composition comprising alkoxy silane; and applying energy to the gaseous composition comprising alkoxysilane in the reaction chamber to induce reaction of the gaseous composition comprising alkoxysilane to deposit an organosilicon film on the substrate, wherein the organosilicon film has a dielectric constant of from ˜2.40 to ˜3.20, an elastic modulus of from ˜6 to ˜30 GPa, and an at. % carbon of from ˜10 to˜45 as measured by XPS.

Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

The present disclosure relates to methods for providing a silicon nitride film. In particular, the film can be a carbon-doped, silicon nitride film. Methods can include depositing a doped silicon nitride and then plasma treating the doped silicon nitride to provide a conformal film.

Provided is a composition including: (component A) a silane coupling agent including a carbon chain that contains at least one etheric oxygen atom; and (component B) a silane coupling agent including a siloxane structure.

Methods and apparatus for forming silicon oxide using chlorosilane and aminosilane precursors are provided herein.

The invention discloses a soluble alkaline salt scale inhibitor and a preparation method thereof, and belongs to the technical field of oilfield chemistry. The soluble alkaline salt scale inhibitor is prepared from amphiphilic modified graphene oxide, a surfactant, inorganic salt and deionized water, the amphiphilic modified graphene oxide contains a large amount of carboxyl groups, sulfonic acid groups, hydroxyl groups and the like, and has good metal ion chelating property; meanwhile, through the hydrophobic association effect and hydrogen-bond interaction between modified graphene grafted long carbon chains, the bonding probability between sodium ions of the soluble saline-alkali salt and bicarbonate radicals, carbonate radicals and chloride ions is further weakened, and through the synergistic effect of the amphiphilic modified graphene oxide, the surfactant and the inorganic salt, the salt scale inhibition effect is further improved; the method is especially suitable for soluble alkali salt water quality conditions of high temperature, high alkali and high salinity, can solve the problems of oilfield water injection, fracturing flowback strata and wellbore salt deposition, and has a good popularization prospect.

A method for efficiently and safely cleaning an apparatus for tin compound and a highly purified tin compound apparatus are provided. A cleaning method for an apparatus that has been in contact with a tin compound having formula (1) below includes at least steps (A) to (C), in which step (B) is performed after step (A), and step (C) is performed after step (B):(A) a step of cleaning the apparatus with a non-protic solvent,(B) a step of cleaning the apparatus with alcohol, and(C) a step of cleaning the apparatus with ultrapure water having a resistivity value of 17 MΩ·cm at 25° C.RpSnXm  (1)In formula (1), R is a hydrocarbon group, p is an integer from 1 to 3, X is a hydrolyzable substituent, and m=4−p.

The present invention uses commercially available 3-aminopropylsilane coupling agent, diallylamino polyether acrylate, and an alkylating agent, or γ-propanesultone, or γ-butyrolactone as raw materials, and through an aza-Michael addition reaction and a quaternization reaction, a multifunctional silane coupling agent containing one or more quaternary ammonium cations, or sulfobetaine, or carboxybetaine in its molecular structure is prepared, which is used for the surface modification of bioactive glass, and the bioactivity, antibacterial and antifungal properties, and hydrophilicity enhancement effects after the surface modification of bioactive glass are obtained.

A method for efficiently and safely cleaning an apparatus for a tin compound and a highly purified apparatus for a tin compound are provided. A method of cleaning an apparatus that has been in contact with a tin compound having formula (1) includes at least steps (A) to (C) in this order:(A) a step of cleaning the apparatus with a non-protonic solvent,(B) a step of cleaning the apparatus with an acidic aqueous solution and / or alkaline aqueous solution, and(C) a step of cleaning the apparatus with ultrapure water having a resistivity of 17 MΩ·cm at 25° C.RpSnXm  (1)R is a hydrocarbon group, p is an integer of 0 to 3, X is a hydrolyzable substituent, and m=4-p.

The invention discloses a lubricant composition and application thereof in processing of a high-weather-resistance PC hollow plate, and relates to the technical field of lubricant compositions. The lubricant composition comprises the following components in parts by mass: 40-60 parts of base oil, 5-15 parts of a weather-resistant stable additive, 3-8 parts of an anti-wear reagent at extreme pressure, 2-6 parts of a dispersing agent, 1-4 parts of an antioxidant, 0.5-2 parts of a coupling agent and 20-30 parts of a solvent. Through the molecular collaborative design of the polar base oil and the solvent, the thermal decomposition tendency in the processing process is remarkably reduced, and a lubricating system is promoted to be upgraded to a low-volatilization and low-pollution green process direction. A weather-resistant additive molecular skeleton with anti-oxidation and anti-ultraviolet characteristics is innovatively constructed, integration of multiple protection mechanisms in material processing and service stages is realized, and dependence on secondary addition of auxiliaries in a traditional process is reduced.

The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

The invention relates to the technical field of concrete, in particular to epoxy resin concrete for a catch basin and a preparation process thereof. The cement, the silica fume, the fine aggregate, the coarse aggregate, the water reducing agent, the fly ash, the modified epoxy resin, the curing agent, the diluent and the water are mixed to obtain epoxy concrete slurry, and the epoxy concrete with good mechanical property and ageing resistance for the catch basin is obtained through curing. A preparation process of the modified epoxy resin comprises the following steps: (1) preparing eugenol glycidyl ether by taking eugenol and epoxy chloropropane as raw materials; (2) enabling eugenol glycidyl ether to react with 1, 1, 3, 3-tetramethyldisiloxane, and then grafting 4-isopropylamino diphenylamine, so as to obtain silicon-containing dihydric alcohol; (3) mixing silicon-containing dihydric alcohol and polyethylene glycol, and reacting with isophorone diisocyanate to obtain a silicon-containing polyurethane prepolymer; and (4) mixing the silicon-containing polyurethane prepolymer with epoxy resin to obtain the modified epoxy resin.

The invention relates to the technical field of fabrics, and discloses an anti-ultraviolet modified polyester fabric preparation method, which comprises: using bis (3-chloropropyl) amine and allyltriethoxysilane as raw materials, carrying out Michael addition to obtain an intermediate 1, carrying out a ring-opening reaction on the intermediate 1 and 1, 3-propane sultone to obtain an intermediate 2, and sequentially carrying out a ring-opening reaction on the intermediate 2 and 2, 3-propane sultone to obtain the anti-ultraviolet modified polyester fabric. The preparation method comprises the following steps: carrying out substitution reaction and quaternization reaction on 2, 4-dihydroxybenzophenone and modified ferulic acid to obtain bis-benzophenone quaternary ammonium salt and ferulate terylene quaternary ammonium salt, and carrying out condensation on the ferulate terylene quaternary ammonium salt and siloxy groups contained in the bis-benzophenone quaternary ammonium salt and hydroxyl contained in the alkali-treated polyester fabric to obtain the polyester fabric. The anti-ultraviolet modified polyester fabric is obtained.

The invention relates to the technical field of supported metallocene catalysts, in particular to a supported metallocene catalyst additive as well as a preparation method and application thereof. The supported metallocene catalyst additive has the following structure: # imgabs0 #, R is selected from C1-C10 alkyl groups, R1 and R3 are selected from alkyl groups and adamantyl groups and are located at ortho-para positions of-OH, R2 is selected from C1-C10 alkyl groups and cycloalkyl groups, and R'is selected from alkyl groups. The additive can greatly retain the catalytic activity and copolymerization performance of a metallocene catalyst, improve the metal loading capacity and catalytic activity, and reduce the dosage of a traditional cocatalyst MAO.

The invention discloses a boron-nitrogen compound containing a naphthenic spacer group, a blue light-emitting composition and an organic electroluminescent device containing the blue light-emitting composition. The structural general formula of the boron-nitrogen compound is as shown in formula I. A naphthenic base structure which can be substituted by aryl or connected in parallel or substituted by naphthenic base is introduced to positions, namely Ar1 and Ar2, of side phenyl of a boron-nitrogen parent nucleus, so that the size of the boron-nitrogen parent nucleus in the plane direction can be obviously expanded, and the compound has relatively good molecular orientation during film formation; meanwhile, when the compound is used as a guest material and is combined with an anthracene host material shown in a formula II to prepare an organic electroluminescent device, the influence of relatively strong pi-pi interaction among compound molecules on a boron-nitrogen parent nucleus in the guest material can be weakened, and the risks of spectrum widening and spectrum red shift are eliminated; and finally, the prepared organic light-emitting device has more excellent BI efficiency and longer service life. # imgabs0 #

The invention belongs to the technical field of organic compounds, and particularly relates to a multifunctional organic silicon glycosyl amide cationic surfactant as well as a preparation method and application thereof. The preparation method of the surfactant comprises the following steps: carrying out amine ester reaction on glucolactone and N, N-dimethyl dipropylene triamine to obtain a precursor; carrying out substitution reaction on the precursor and bromododecane to obtain an intermediate; the intermediate and 3-chloropropyl methyl dimethoxy silane or 3-chloropropyl methyl trimethoxy silane are subjected to a quaternization reaction, and the surfactant is obtained. The surfactant has good environmental protection property and biocompatibility, is non-toxic and non-irritant, can sterilize and improve the rewettability of the material surface, and has wide application prospects in the aspects of pesticide, textile, daily chemical industry and material transportation and storage.

The invention relates to a decarboxylation coupling method catalyzed by N-heterocyclic carbene. Small organic molecule N-heterocyclic carbene is used as an organic catalyst, manganese is used as a reducing agent, aromatic acid or derivatives thereof and an electrophilic reagent are subjected to cross coupling, and multi-structure ketone is prepared. Small organic molecule N-heterocyclic carbene is used as an organic catalyst, manganese is combined as a reducing agent, cross coupling of aromatic acid or derivatives thereof and some cheap and easily available electrophilic reagents can be promoted, ketones with various structures can be provided at high yield, and the method is especially suitable for preparation of high-steric-hindrance ketone compounds and has wide application prospects. The method has the advantages of high yield, convenience in separation, high efficiency, mildness, low-cost economy and high industrial application value, and the requirement on transition metal catalysis can be reduced.

The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and / or non-diabetic kidney disease (NDKD). (I)

The invention provides a preparation method and intermediates of alasset hydrochloride, which comprises the following steps: reacting an initial raw material as shown in a formula 1, which is protected by bare phenolic hydroxyl groups or different protecting groups, with bis (pinacolato) diboron to obtain an intermediate as shown in a formula 2, carrying out coupling reaction on the intermediate and a compound as shown in a formula 3 to obtain a corresponding hydroxyl-protected intermediate as shown in a formula 4, and separating and purifying the intermediate to obtain the alasset hydrochloride. The preparation method comprises the following steps: carrying out catalyst pressurized hydrogenation, carrying out asymmetric chiral hydrogenation to obtain an intermediate as shown in a formula 5, carrying out substitution or reductive amination to obtain an intermediate as shown in a formula 6, carrying out nucleophilic substitution on the intermediate as shown in a formula 7 to obtain an intermediate as shown in a formula 8, and carrying out deprotection to obtain a target product as shown in a formula I. According to the invention, a chiral resolution link in the existing preparation technology is avoided, and a chiral group is introduced through asymmetric hydrogenation, so that the yield is greatly improved, the production cost is greatly reduced, the tedious and tedious synthesis steps in the original process are shortened, and the post-treatment is simpler and more controllable.

The present invention provides a multifunctional silane coupling agent, which is prepared from commercially available 3-aminopropylsilane coupling agent, acryloxy polyetheramine, and one of an alkylating agent, polyether sulfonate, γ-propane sultone or γ-butyrolactone through Michael addition reaction and quaternization reaction. The multifunctional silane coupling agent is a new variety carrying zwitterions, quaternary ammonium cations and polyether chains, enriching the functions and application scope of silane coupling agents. It can endow some modified materials with surface hydrophilicity, conductivity, antibacterial, antifogging, antifouling, biocompatibility, anticoagulant and wet lubrication properties, etc. at the same time.

Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Processes for preparing Compound I, and pharmaceutically acceptable salts and solvates thereof, pharmaceutically acceptable solid (e.g., crystalline or amorphous) forms of Compound I, pharmaceutical compositions comprising the same, methods of treating pain using the same, and methods for making the same are disclosed.

The present invention relates to a nitrogen-containing tricyclic PRMT5 inhibitor, a method for producing the same, and a pharmaceutical use thereof. In particular, the present invention relates to a PRMT5 inhibitor having a structure represented by formula (I), a method for producing the same, a drug composition containing the same, and its use as a PRMT5 inhibitor and its use in the treatment and / or prevention of diseases mediated by PRMT5. Here, each substituent of formula (I) is the same as defined in the specification. 【Chemical 1】 TIFF2025516926000204.tif44144

The invention discloses low-VOC (volatile organic compound) environment-friendly end-capped mercapto silane as well as a preparation method and application thereof.The preparation method comprises the following steps: by taking chloroalkyl trialkoxysilane and linear alkyl polyether alcohol as raw materials, reacting to form an intermediate c; reacting alkyl acyl chloride with sodium sulfide or sodium hydrosulfide to form an intermediate e; and reacting the intermediate c with the intermediate e to obtain a final product. Silane is used as a rubber auxiliary agent, so that the volatilization amount of alcohols in the internal mixing process of a rubber compound can be greatly reduced, the emission amount of VOC during operation is reduced, meanwhile, the vulcanization performance of a rubber material can be improved, the scorching time of the rubber material can be prolonged, the reinforcing effect of vulcanized rubber can be improved, the physical and mechanical properties of the vulcanized rubber can be improved, and the wet skid resistance of tread rubber can be improved; therefore, the environment-friendly rubber auxiliary agent is a multifunctional environment-friendly rubber auxiliary agent.