859results about "Preparation by hydrogen halide split-off" patented technology

Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

The invention discloses a catalytic synthesis method of 1, 1, 3, 3, 3-pentafluoropropylene, which comprises the following steps: (1) introducing a raw material 1, 1, 1, 3, 3, 3-hexafluoropropane into a reactor, and reacting under the action of a catalyst to obtain crude 1, 1, 3, 3, 3-pentafluoropropylene, the catalyst containing Cr2O3 and one of metal oxides of Al, Bi and Co; (2) carrying out water washing, alkali washing and drying on the crude 1, 1, 3, 3, 3-pentafluoropropene, and then introducing the crude 1, 1, 3, 3, 3-pentafluoropropene into a first rectifying tower for separation to obtain a mixture containing 1, 1, 1, 3, 3-pentafluoropropene and a small amount of by-products; and (3) introducing the mixture containing 1, 1, 1, 3, 3-pentafluoropropylene and a small amount of by-products into a second rectifying tower, and separating to obtain a 1, 1, 1, 3, 3-pentafluoropropylene product. The method has the advantages of simple process, high catalyst activity, low cost and environmental protection.

Disclosed in the present invention is a method for co-producing 3,3,3-trifluoropropene and 2,3,3,3-tetrafluoropropene. The method comprises: introducing 1,1,1,3-tetrachloropropane, 1,1,1,2,3-pentachloropropane, and hydrogen fluoride into a first reactor, and reacting under the action of a first catalyst to obtain a first reactor reaction product; performing rectification on the first reactor reaction product to obtain a 3,3,3-trifluoropropene product and a tower kettle product, mixing the tower kettle product with hydrogen fluoride, and then introducing the mixture into a second reactor, and reacting under the action of a second catalyst to obtain a second reactor reaction product; and separating the second reactor reaction product from hydrogen chloride, water washing, alkaline washing, and drying to obtain a 2,3,3,3-tetrafluoropropene product. The present invention has the advantages of simple process, high efficiency, flexible operation, low investment, and low energy consumption.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a 1, 1, 1, 3-tetrachloropropane dehydrochlorination production process. Comprising the following steps: (1) modifying gamma-aluminum oxide powder by adopting an amino-containing silane coupling agent to prepare modified gamma-aluminum oxide powder; (2) preparing trivalent metal salt-loaded modified gamma-aluminum oxide powder by adopting an impregnation process to obtain a catalyst; (3) activating the catalyst; and (4) adjusting the reaction temperature and pressure, introducing 1, 1, 1, 3-tetrachloropropane, and carrying out a dehydrochlorination reaction to obtain the 1, 1, 3-trichloropropene. According to the catalyst, active components are attached to a solid matrix, so that the phenomena of chlorine absorption, coking and the like are reduced, and on the basis of high conversion rate and selectivity, the stability of the catalyst is further improved, and side reaction is avoided.

This method for producing a halogenated alkene comprises converting a halogenated alkane which has 2-4 carbon atoms and contains a fluorine atom into a halogenated alkene which has 2-4 carbon atoms and contains a fluorine atom in a gas phase in the presence of silicon oxide and an alkali metal element.

The method for producing a halogenated alkene converts a halogenated alkane having 2 to 4 carbon atoms and containing a fluorine atom into a halogenated alkene having 2 to 4 carbon atoms and containing a fluorine atom in the gas phase in the presence of silicon oxide and an alkali metal element.

The invention belongs to the technical field of catalyst preparation, and particularly relates to a catalyst special for tetrachloropropane dehydrochlorination and a preparation method and application thereof. The preparation method of the catalyst comprises the following steps: (1) placing gamma-alumina powder in a solvent, adding an amino-containing silane coupling agent, and heating for reaction to obtain modified gamma-alumina powder; and (2) preparing modified gamma-alumina powder loaded with trivalent iron salt or trivalent chromium salt, and drying to obtain the special catalyst for dehydrochlorination of tetrachloropropane. Iron ions or chromium ions complexed by an amino silane coupling agent improve the stability of the active component, the active component is attached to a gamma-alumina matrix by the catalyst, the activity of the main catalyst can be effectively regulated and controlled, the phenomena of chlorine absorption, coking and the like are reduced, the dehydrochlorination reaction is carried out when tetrachloropropane is in contact with the solid matrix, and the dehydrochlorination reaction is carried out when the tetrachloropropane is in contact with the solid matrix. On the basis of high conversion rate and selectivity, side reaction is avoided.

The invention discloses a method for preparing 1, 2, 3-trichloropropene with high selectivity by dehydrochlorination of 1, 2, 2, 3-tetrachloropropane, and belongs to the technical field of catalysis. The method comprises the following steps: stirring 1, 2, 2, 3-tetrachloropropane and a sodium hydroxide solution under the conditions of normal pressure and 40-100 DEG C for reflux reaction, after the reaction is finished, cooling the reaction liquid to room temperature, separating the liquid by using a separating funnel, rectifying the obtained oil phase to obtain 1, 2, 3-trichloropropene, adding an improver into the reaction system, and carrying out solid-liquid separation to obtain the 1, 2, 3-trichloropropene. The improver is a complex system composed of a metal salt and a bidentate phosphine ligand or a metal composite oxide. The method provided by the invention has the advantages of fewer reaction steps and simpler equipment, the yield of 1, 2, 3-trichloropropene is as high as 86%, the conversion rate of 1, 2, 2, 3-tetrachloropropane is as high as 92%, the selectivity of the target product is as high as 98%, and the conversion rate and the selectivity of the target product are remarkably improved.

Disclosed herein are fluoroolefin compositions, methods of producing the same, methods and systems using the same, and systems containing the HFO-1234ze compositions. The inventive compositions are useful as refrigerants in air conditioning and refrigeration systems, and also as blowing agents.

The invention belongs to the technical field of catalyst preparation, and particularly relates to a pentachloropropane dehydrochlorination catalyst and a preparation process of tetrachloropropene. The preparation process of the catalyst comprises the following steps: (1) modifying gamma-aluminum oxide powder by adopting an epoxy group-containing silane coupling agent to obtain activated gamma-aluminum oxide powder; (2) dispersing the activated gamma-aluminum oxide powder and polyamino POSS in a solvent, and stirring for reaction to obtain modified gamma-aluminum oxide powder; and (3) preparing trivalent metal salt-loaded modified gamma-alumina powder, and drying to obtain the pentachloropropane dehydrochlorination catalyst. The epoxy group-containing silane coupling agent not only improves the dispersion performance of alumina, but also plays a medium role, so that POSS is attached to the surface of alumina powder, and the stability of the catalyst is improved. Amino groups on POSS are used for complexing trivalent metal ions, and POSS micromolecules can also serve as a transmission track of a substrate, so that the catalytic activity is improved.

The present disclosure provides a method for more efficiently obtaining HFO-1132(E) and / or HFO-1132(Z) than in conventional methods.The present disclosure specifically provides a method for producing a composition comprising trans-1,2-difluoroethylene (HFO-1132(E)) and / or cis-1,2-difluoroethylene (HFO-1132 (Z)), the method comprising:(x) supplying a starting material gas comprising 1,1,2-trifluoroethane (HFC-143), HFO-1132(E) and / or HFO-1132(Z), and a diluent gas to a reactor containing a catalyst to perform a dehydrofluorination reaction of HFC-143 and an isomerization reaction between HFO-1132(E) and HFO-1132(Z), thereby obtaining a reaction product comprising HFO-1132(E) and HFO-1132(Z), wherein the content of the diluent gas in the starting material gas is 1 to 80 mol %.

The present application relates to compositions comprising 3,3,4,4,4-pentafluoro-1-butene (HFO-1345zf, CF3CF2CH=CH2) processes of preparing such compositions and their use.

The invention discloses a method for efficiently preparing 1, 1, 2, 3-tetrachloropropene, which comprises the following steps: by taking 1, 1, 2, 2, 3-pentachloropropane / 1, 1, 1, 2, 3-pentachloropropane as a raw material, carrying out dehydrochlorination reaction in a tank reactor under the action of a composite catalyst to prepare the 1, 1, 2, 3-tetrachloropropene. Compared with the traditional dehydrochlorination of alkali liquor, the method has the advantages of less generation of three wastes, simple process operation and easiness in industrial implementation. The prepared composite catalyst can be suitable for pentachloropropane of different structures as a raw material, the catalyst compatibility is high, the application scene is wide, the composite catalyst is good in catalytic activity and high in selectivity, and the selectivity of tetrachloropropene is 95% or above and can reach 99% to the maximum. Meanwhile, the composite catalyst is good in regeneration performance, the inactivated catalyst is easy to regenerate, and the catalytic activity is not reduced after regeneration; the composite catalyst material is easy to obtain and low in price, the production cost can be greatly saved, and industrial production is facilitated.

The present application relates to compositions comprising E-1,1,1,2,2,5,5,6,6,6-decafluoro-3-hexene (E-HFO-153-10mczz, E-CF3CF2CH=CHCF2CF3) processes of preparing such compositions and their use.

The utility model provides a system for producing vinyl chloride through oxychlorination, and belongs to the field of vinyl chloride synthesis. According to the system for producing vinyl chloride through oxychlorination, dichloroethane is prepared through the oxychlorination reaction unit, then the dichloroethane is refined through the refining unit, then the refined dichloroethane is cracked in the cracking unit to prepare vinyl chloride, and finally the vinyl chloride is obtained through purification in the vinyl chloride refining unit. Dichloroethane is prepared through a direct chlorination reaction unit, so that the yield of dichloroethane is increased, and a raw material is provided for cracking of dichloroethane; according to the system for producing vinyl chloride through oxychlorination, dichloroethane is prepared through the oxychlorination reaction unit and the direct chlorination unit, so that the working efficiency of the system is improved.

The invention relates to a process for the preparation of a halogenated 1,3-butadiene by dehydrohalogenation of a halogenated 1-butene. Preferably, the process is for the preparation of 2-chloro-1,3-butadiene (CP) from 3,4-dichloro-1-butene (3,4-DBN), or for the preparation of 2,3-dichloro-1,3-butadiene (DCB) from 2,3,4-trichloro-1-butene (TCB). The dehydrohalogenation is performed in the presence of an organic base that forms a salt with eliminated hydrohalogenic acid and provides a low melting halide salt, preferably an organic salt melting below 100 °C, that is an ionic liquid. Preferably, halogenated 1,3-butadiene is separated from the reaction mixture by in-situ distillation. Organic base is recovered from the low melting organic salt by e.g. heating and release of hydrohalogenic acid. After purification, recovered organic base is recycled into the process.

The invention discloses a method for preparing 1-chloro-2, 3, 3-trifluoropropene through resource utilization of 1, 1, 2-trifluoroethane, which comprises the following steps: (1) dehydrofluorination: 1, 1, 2-trifluoroethane is subjected to a dehydrofluorination process under the action of a gas-phase dehydrofluorination catalyst to obtain 1, 2-difluoroethylene; (2) telomerization: under the combined action of the prefluorinated telomerization catalyst, the accelerant and the polar aprotic solvent, telomerization is performed on the 1, 2-difluoroethylene and the dichlorofluoromethane to obtain 3, 3-dichloro-1, 1, 2-trifluoropropane; and (3) a dehydrochlorination step: carrying out dehydrochlorination on the 3, 3-dichloro-1, 1, 2-trifluoropropane to obtain the 1-chloro-2, 3, 3-trifluoropropene. The method has the advantages of easily available raw materials, high product selectivity, high purity, easiness in separation, suitability for industrial application and the like.

The invention discloses a preparation method of 1-chloro-2, 3, 3-trifluoropropene, which comprises the following steps: (1) an addition step: carrying out an addition process on chlorotrifluoroethylene and methanol under the action of a free radical initiator to obtain 2-chloro-2, 3, 3-trifluoropropanol; (2) a chlorination step: carrying out a chlorination reaction on the 2-chloro-2, 3, 3-trifluoropropanol under the combined action of a chlorination reagent and a catalyst to obtain 1, 2-dichloro-2, 3, 3-trifluoropropane; and (3) a dehydrochlorination step: carrying out gas phase dehydrochlorination on the 1, 2-dichloro-2, 3, 3-trifluoropropane to obtain the 1-chloro-2, 3, 3-trifluoropropene. The method has the advantages of easily available raw materials, mild reaction conditions, high purity, easiness in separation, suitability for industrial application and the like.

The invention relates to a fluorination catalyst and a method for preparing 2-chloro-3, 3, 3-trifluoropropene. The fluorination catalyst is prepared by the following steps: 1) loading a water-soluble trivalent chromium salt on aluminum oxide according to a molar ratio of Cr to Al of 1: (5-20) by an impregnation method to obtain aluminum oxide loaded with the water-soluble trivalent chromium salt; 2) drying the aluminum oxide loaded with the water-soluble trivalent chromium salt, and roasting at 200-300 DEG C for 2-8 hours to obtain a catalyst precursor; and 3) fluorinating the catalyst precursor with hydrogen fluoride to prepare the fluorination catalyst. The catalyst disclosed by the invention is high in stability, and can be used for preparing 2-chloro-3, 3, 3-trifluoropropene with a simple process and high conversion rate and selectivity.

The present invention relates to the technical field of chemistry, particularly to a 2, 3, 3, 3-tetrafluoropropene preparation method, which comprises: mixing a water-soluble metal salt containing a first metal auxiliary agent and chromium chloride hexahydrate to prepare a first solution, mixing the first solution with first ammonia water, and carrying out first calcination treatment on the obtained first precipitate to obtain a first chromium salt; mixing first chromium salt with graphite and silicon dioxide to obtain a first catalyst precursor, and performing fluorination activation treatment on the first catalyst precursor to obtain a first catalyst; the method comprises the following steps: under the action of a first catalyst, reacting 2-chloro-3, 3, 3-trifluoropropene with hydrogen fluoride to obtain 2, 3, 3, 3-tetrafluoropropene. According to the method, the process route is shortened, the use of highly toxic substances is avoided, the cost is reduced, the pollution to the environment is reduced, and meanwhile, the conversion rate of HCFO-1233xf and the selectivity of HFO-1234yf are improved.

The invention belongs to the technical field of fluorine chemical industry, and particularly relates to a diolefin fluorine-containing vulcanization point monomer and a synthesis method and application thereof, the diolefin fluorine-containing vulcanization point monomer has a structural general formula as shown in formula (I): # imgabs0 #, in the formula, n is a positive integer; the synthesis method comprises the following steps: step 1, in a solvent, mixing perfluorodiiodoalkane with a free radical initiator, then introducing ethylene, and carrying out an addition reaction to obtain an intermediate product; and 2, mixing the intermediate product obtained in the step 1 with an inorganic base, and carrying out an elimination reaction to obtain the diene fluorine-containing vulcanization point monomer. Compared with the prior art, the invention solves the problems of complexity and low efficiency of the synthesis method of the diolefin fluorine-containing vulcanization point monomer in the prior art, and realizes rapid and convenient synthesis of the diolefin fluorine-containing vulcanization point monomer.

The invention discloses a synthesis method of a catalyst for preparing vinyl chloride through catalytic cracking of high-activity 1, 2-dichloroethane, and active components in the catalyst are uniformly dispersed on nitrogen-doped carbon dots loaded on activated carbon. The method comprises the following steps: firstly preparing nitrogen-doped carbon dots containing active components, and then loading the nitrogen-doped carbon dots on activated carbon to prepare the composite catalyst. The catalyst can efficiently catalyze the reaction of cracking 1, 2-dichloroethane to prepare vinyl chloride. Compared with the existing catalyst for preparing vinyl chloride by cracking 1, 2-dichloroethane, the active component has better dispersity, the energy consumption can be greatly reduced, the production cost is reduced, and the catalyst has a very good industrial prospect.

The invention provides a method for preparing p-chloromethyl styrene, which comprises the following steps: (1) in the presence of a catalyst and an assistant, carrying out reaction on paraformaldehyde and hydrogen chloride to obtain a chloromethylation reagent; (2) reacting beta-halogenated ethyl benzene with the chloromethylation reagent obtained in the step (1) to obtain chloromethyl halogenated ethyl benzene; (3) adding an extracting agent into the chloromethyl halogenated ethylbenzene reaction liquid obtained in the step (2) for extraction to obtain an oil layer containing chloromethyl halogenated ethylbenzene and a water-containing acid layer, and crystallizing the oil layer to obtain purified p-chloromethyl halogenated ethylbenzene; and (4) in the presence of a solvent, carrying out elimination reaction on the purified p-chloromethyl halogenated ethyl benzene and alkali to obtain p-chloromethyl styrene.

The invention relates to the technical field of preparation of hydrofluoroolefin, in particular to a method for preparing 2, 3, 3, 3-tetrafluoropropene, which comprises the following steps: carrying out fluorination reaction on 3, 3, 3-trifluoro-2-chloropropene and excessive hydrogen fluoride under the action of a catalyst to generate a first mixture flow containing 1, 1, 1, 2, 2-pentafluoropropane (245cb), and separating the first mixture flow from the first mixture flow to obtain the 2, 3, 3, 3, 3-tetrafluoropropene. Then directly introducing the first mixture flow into a dehydrofluorination reactor for gas phase dehydrofluorination reaction to generate a second mixture flow containing 2, 3, 3, 3-tetrafluoropropene, hydrogen fluoride and unreacted raw materials, finally condensing the second mixture to remove hydrogen chloride, condensing and recycling hydrogen fluoride to obtain a third mixture flow, and rectifying the third mixture flow to obtain 2, 3, 3, 3-tetrafluoropropene. And 3, 3, 3, 3-tetrafluoropropene. According to the invention, unavoidable process wastes in the prior art are converted into recyclable reaction raw materials, the environmental protection and economic pressure of by-product treatment in the prior art is eliminated, meanwhile, the purpose of continuous flow reaction is effectively realized, and the process control difficulty and the process cost are reduced.

Disclosed in the present invention is a method for producing 2,3,3,3-tetrafluoropropene from 1,1,2,3,3,3-hexafluoropropene, comprising: (a) introducing 1,1,2,3,3,3-hexafluoropropene and hydrogen into a first reactor for a catalytic reaction to obtain a first reaction product; (b) separating the first reaction product to obtain 1,1,1,2,3,3-hexafluoropropane; (c) introducing 1,1,1,2,3,3-hexafluoropropane into a second reactor for a catalytic reaction to obtain a second reaction product; (d) separating the second reaction product to obtain 1,2,3,3,3-pentafluoropropene; (e) introducing 1,2,3,3,3-pentafluoropropene and hydrogen into a third reactor for a catalytic reaction to obtain a third reaction product; (f) separating the third reaction product to obtain 1,1,1,2,3-pentafluoropropane; (g) introducing 1,1,1,2,3-pentafluoropropane into a fourth reactor for a catalytic reaction to obtain a fourth reaction product; and (h) separating the fourth reaction product to obtain a final product of 2,3,3,3-tetrafluoropropene. The present invention has the advantages of being simple in process, low in cost, high in efficiency, green, and environmentally friendly.

The invention discloses a method for preparing 1-chloro-1, 1-difluoroethane and co-producing 1, 1-difluoroethylene, which comprises the following steps: mixing 1, 1-difluoroethane, chlorine and a hot substance, preheating, introducing into a reactor, and carrying out thermal chlorination reaction to obtain 1-chloro-1, 1-difluoroethane and 1, 1-difluoroethylene, wherein the reaction temperature of the thermal chlorination reaction is 300-600 DEG C, and the reaction retention time is less than or equal to 150s. The hot substance is introduced in the hot chlorination reaction process to take away the heat of the reaction system, so that the temperature rise of the reaction system is prevented from being too fast, the reaction temperature is easy to control, and the yield of the target product is improved. Besides, the method avoids the use of a catalyst, can co-produce the downstream product 1, 1-difluoroethylene of the 1-chloro-1, 1-difluoroethane, has the advantages of simple process, high production efficiency, low production cost, continuous production and the like, and is a feasible industrial route for production.