616results about "Preparation by hydrogen halide split-off" patented technology

Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.

Disclosed in the present invention is a method for co-producing 3,3,3-trifluoropropene and 2,3,3,3-tetrafluoropropene. The method comprises: introducing 1,1,1,3-tetrachloropropane, 1,1,1,2,3-pentachloropropane, and hydrogen fluoride into a first reactor, and reacting under the action of a first catalyst to obtain a first reactor reaction product; performing rectification on the first reactor reaction product to obtain a 3,3,3-trifluoropropene product and a tower kettle product, mixing the tower kettle product with hydrogen fluoride, and then introducing the mixture into a second reactor, and reacting under the action of a second catalyst to obtain a second reactor reaction product; and separating the second reactor reaction product from hydrogen chloride, water washing, alkaline washing, and drying to obtain a 2,3,3,3-tetrafluoropropene product. The present invention has the advantages of simple process, high efficiency, flexible operation, low investment, and low energy consumption.

The invention belongs to the technical field of chemical synthesis, and particularly relates to a 1, 1, 1, 3-tetrachloropropane dehydrochlorination production process. Comprising the following steps: (1) modifying gamma-aluminum oxide powder by adopting an amino-containing silane coupling agent to prepare modified gamma-aluminum oxide powder; (2) preparing trivalent metal salt-loaded modified gamma-aluminum oxide powder by adopting an impregnation process to obtain a catalyst; (3) activating the catalyst; and (4) adjusting the reaction temperature and pressure, introducing 1, 1, 1, 3-tetrachloropropane, and carrying out a dehydrochlorination reaction to obtain the 1, 1, 3-trichloropropene. According to the catalyst, active components are attached to a solid matrix, so that the phenomena of chlorine absorption, coking and the like are reduced, and on the basis of high conversion rate and selectivity, the stability of the catalyst is further improved, and side reaction is avoided.

This method for producing a halogenated alkene comprises converting a halogenated alkane which has 2-4 carbon atoms and contains a fluorine atom into a halogenated alkene which has 2-4 carbon atoms and contains a fluorine atom in a gas phase in the presence of silicon oxide and an alkali metal element.

The method for producing a halogenated alkene converts a halogenated alkane having 2 to 4 carbon atoms and containing a fluorine atom into a halogenated alkene having 2 to 4 carbon atoms and containing a fluorine atom in the gas phase in the presence of silicon oxide and an alkali metal element.

The invention belongs to the technical field of catalyst preparation, and particularly relates to a catalyst special for tetrachloropropane dehydrochlorination and a preparation method and application thereof. The preparation method of the catalyst comprises the following steps: (1) placing gamma-alumina powder in a solvent, adding an amino-containing silane coupling agent, and heating for reaction to obtain modified gamma-alumina powder; and (2) preparing modified gamma-alumina powder loaded with trivalent iron salt or trivalent chromium salt, and drying to obtain the special catalyst for dehydrochlorination of tetrachloropropane. Iron ions or chromium ions complexed by an amino silane coupling agent improve the stability of the active component, the active component is attached to a gamma-alumina matrix by the catalyst, the activity of the main catalyst can be effectively regulated and controlled, the phenomena of chlorine absorption, coking and the like are reduced, the dehydrochlorination reaction is carried out when tetrachloropropane is in contact with the solid matrix, and the dehydrochlorination reaction is carried out when the tetrachloropropane is in contact with the solid matrix. On the basis of high conversion rate and selectivity, side reaction is avoided.

Disclosed herein are fluoroolefin compositions, methods of producing the same, methods and systems using the same, and systems containing the HFO-1234ze compositions. The inventive compositions are useful as refrigerants in air conditioning and refrigeration systems, and also as blowing agents.

The invention belongs to the technical field of catalyst preparation, and particularly relates to a pentachloropropane dehydrochlorination catalyst and a preparation process of tetrachloropropene. The preparation process of the catalyst comprises the following steps: (1) modifying gamma-aluminum oxide powder by adopting an epoxy group-containing silane coupling agent to obtain activated gamma-aluminum oxide powder; (2) dispersing the activated gamma-aluminum oxide powder and polyamino POSS in a solvent, and stirring for reaction to obtain modified gamma-aluminum oxide powder; and (3) preparing trivalent metal salt-loaded modified gamma-alumina powder, and drying to obtain the pentachloropropane dehydrochlorination catalyst. The epoxy group-containing silane coupling agent not only improves the dispersion performance of alumina, but also plays a medium role, so that POSS is attached to the surface of alumina powder, and the stability of the catalyst is improved. Amino groups on POSS are used for complexing trivalent metal ions, and POSS micromolecules can also serve as a transmission track of a substrate, so that the catalytic activity is improved.

The present disclosure provides a method for more efficiently obtaining HFO-1132(E) and / or HFO-1132(Z) than in conventional methods.The present disclosure specifically provides a method for producing a composition comprising trans-1,2-difluoroethylene (HFO-1132(E)) and / or cis-1,2-difluoroethylene (HFO-1132 (Z)), the method comprising:(x) supplying a starting material gas comprising 1,1,2-trifluoroethane (HFC-143), HFO-1132(E) and / or HFO-1132(Z), and a diluent gas to a reactor containing a catalyst to perform a dehydrofluorination reaction of HFC-143 and an isomerization reaction between HFO-1132(E) and HFO-1132(Z), thereby obtaining a reaction product comprising HFO-1132(E) and HFO-1132(Z), wherein the content of the diluent gas in the starting material gas is 1 to 80 mol %.

The present application relates to compositions comprising 3,3,4,4,4-pentafluoro-1-butene (HFO-1345zf, CF3CF2CH=CH2) processes of preparing such compositions and their use.

The invention discloses a method for efficiently preparing 1, 1, 2, 3-tetrachloropropene, which comprises the following steps: by taking 1, 1, 2, 2, 3-pentachloropropane / 1, 1, 1, 2, 3-pentachloropropane as a raw material, carrying out dehydrochlorination reaction in a tank reactor under the action of a composite catalyst to prepare the 1, 1, 2, 3-tetrachloropropene. Compared with the traditional dehydrochlorination of alkali liquor, the method has the advantages of less generation of three wastes, simple process operation and easiness in industrial implementation. The prepared composite catalyst can be suitable for pentachloropropane of different structures as a raw material, the catalyst compatibility is high, the application scene is wide, the composite catalyst is good in catalytic activity and high in selectivity, and the selectivity of tetrachloropropene is 95% or above and can reach 99% to the maximum. Meanwhile, the composite catalyst is good in regeneration performance, the inactivated catalyst is easy to regenerate, and the catalytic activity is not reduced after regeneration; the composite catalyst material is easy to obtain and low in price, the production cost can be greatly saved, and industrial production is facilitated.

The present application relates to compositions comprising E-1,1,1,2,2,5,5,6,6,6-decafluoro-3-hexene (E-HFO-153-10mczz, E-CF3CF2CH=CHCF2CF3) processes of preparing such compositions and their use.

The invention relates to a process for the preparation of a halogenated 1,3-butadiene by dehydrohalogenation of a halogenated 1-butene. Preferably, the process is for the preparation of 2-chloro-1,3-butadiene (CP) from 3,4-dichloro-1-butene (3,4-DBN), or for the preparation of 2,3-dichloro-1,3-butadiene (DCB) from 2,3,4-trichloro-1-butene (TCB). The dehydrohalogenation is performed in the presence of an organic base that forms a salt with eliminated hydrohalogenic acid and provides a low melting halide salt, preferably an organic salt melting below 100 °C, that is an ionic liquid. Preferably, halogenated 1,3-butadiene is separated from the reaction mixture by in-situ distillation. Organic base is recovered from the low melting organic salt by e.g. heating and release of hydrohalogenic acid. After purification, recovered organic base is recycled into the process.

The invention discloses a method for preparing 1-chloro-2, 3, 3-trifluoropropene through resource utilization of 1, 1, 2-trifluoroethane, which comprises the following steps: (1) dehydrofluorination: 1, 1, 2-trifluoroethane is subjected to a dehydrofluorination process under the action of a gas-phase dehydrofluorination catalyst to obtain 1, 2-difluoroethylene; (2) telomerization: under the combined action of the prefluorinated telomerization catalyst, the accelerant and the polar aprotic solvent, telomerization is performed on the 1, 2-difluoroethylene and the dichlorofluoromethane to obtain 3, 3-dichloro-1, 1, 2-trifluoropropane; and (3) a dehydrochlorination step: carrying out dehydrochlorination on the 3, 3-dichloro-1, 1, 2-trifluoropropane to obtain the 1-chloro-2, 3, 3-trifluoropropene. The method has the advantages of easily available raw materials, high product selectivity, high purity, easiness in separation, suitability for industrial application and the like.

The invention discloses a preparation method of 1-chloro-2, 3, 3-trifluoropropene, which comprises the following steps: (1) an addition step: carrying out an addition process on chlorotrifluoroethylene and methanol under the action of a free radical initiator to obtain 2-chloro-2, 3, 3-trifluoropropanol; (2) a chlorination step: carrying out a chlorination reaction on the 2-chloro-2, 3, 3-trifluoropropanol under the combined action of a chlorination reagent and a catalyst to obtain 1, 2-dichloro-2, 3, 3-trifluoropropane; and (3) a dehydrochlorination step: carrying out gas phase dehydrochlorination on the 1, 2-dichloro-2, 3, 3-trifluoropropane to obtain the 1-chloro-2, 3, 3-trifluoropropene. The method has the advantages of easily available raw materials, mild reaction conditions, high purity, easiness in separation, suitability for industrial application and the like.

The invention relates to a fluorination catalyst and a method for preparing 2-chloro-3, 3, 3-trifluoropropene. The fluorination catalyst is prepared by the following steps: 1) loading a water-soluble trivalent chromium salt on aluminum oxide according to a molar ratio of Cr to Al of 1: (5-20) by an impregnation method to obtain aluminum oxide loaded with the water-soluble trivalent chromium salt; 2) drying the aluminum oxide loaded with the water-soluble trivalent chromium salt, and roasting at 200-300 DEG C for 2-8 hours to obtain a catalyst precursor; and 3) fluorinating the catalyst precursor with hydrogen fluoride to prepare the fluorination catalyst. The catalyst disclosed by the invention is high in stability, and can be used for preparing 2-chloro-3, 3, 3-trifluoropropene with a simple process and high conversion rate and selectivity.

The present invention relates to the technical field of chemistry, particularly to a 2, 3, 3, 3-tetrafluoropropene preparation method, which comprises: mixing a water-soluble metal salt containing a first metal auxiliary agent and chromium chloride hexahydrate to prepare a first solution, mixing the first solution with first ammonia water, and carrying out first calcination treatment on the obtained first precipitate to obtain a first chromium salt; mixing first chromium salt with graphite and silicon dioxide to obtain a first catalyst precursor, and performing fluorination activation treatment on the first catalyst precursor to obtain a first catalyst; the method comprises the following steps: under the action of a first catalyst, reacting 2-chloro-3, 3, 3-trifluoropropene with hydrogen fluoride to obtain 2, 3, 3, 3-tetrafluoropropene. According to the method, the process route is shortened, the use of highly toxic substances is avoided, the cost is reduced, the pollution to the environment is reduced, and meanwhile, the conversion rate of HCFO-1233xf and the selectivity of HFO-1234yf are improved.

The invention belongs to the technical field of fluorine chemical industry, and particularly relates to a diolefin fluorine-containing vulcanization point monomer and a synthesis method and application thereof, the diolefin fluorine-containing vulcanization point monomer has a structural general formula as shown in formula (I): # imgabs0 #, in the formula, n is a positive integer; the synthesis method comprises the following steps: step 1, in a solvent, mixing perfluorodiiodoalkane with a free radical initiator, then introducing ethylene, and carrying out an addition reaction to obtain an intermediate product; and 2, mixing the intermediate product obtained in the step 1 with an inorganic base, and carrying out an elimination reaction to obtain the diene fluorine-containing vulcanization point monomer. Compared with the prior art, the invention solves the problems of complexity and low efficiency of the synthesis method of the diolefin fluorine-containing vulcanization point monomer in the prior art, and realizes rapid and convenient synthesis of the diolefin fluorine-containing vulcanization point monomer.

The invention provides a method for preparing p-chloromethyl styrene, which comprises the following steps: (1) in the presence of a catalyst and an assistant, carrying out reaction on paraformaldehyde and hydrogen chloride to obtain a chloromethylation reagent; (2) reacting beta-halogenated ethyl benzene with the chloromethylation reagent obtained in the step (1) to obtain chloromethyl halogenated ethyl benzene; (3) adding an extracting agent into the chloromethyl halogenated ethylbenzene reaction liquid obtained in the step (2) for extraction to obtain an oil layer containing chloromethyl halogenated ethylbenzene and a water-containing acid layer, and crystallizing the oil layer to obtain purified p-chloromethyl halogenated ethylbenzene; and (4) in the presence of a solvent, carrying out elimination reaction on the purified p-chloromethyl halogenated ethyl benzene and alkali to obtain p-chloromethyl styrene.

The invention relates to the technical field of preparation of hydrofluoroolefin, in particular to a method for preparing 2, 3, 3, 3-tetrafluoropropene, which comprises the following steps: carrying out fluorination reaction on 3, 3, 3-trifluoro-2-chloropropene and excessive hydrogen fluoride under the action of a catalyst to generate a first mixture flow containing 1, 1, 1, 2, 2-pentafluoropropane (245cb), and separating the first mixture flow from the first mixture flow to obtain the 2, 3, 3, 3, 3-tetrafluoropropene. Then directly introducing the first mixture flow into a dehydrofluorination reactor for gas phase dehydrofluorination reaction to generate a second mixture flow containing 2, 3, 3, 3-tetrafluoropropene, hydrogen fluoride and unreacted raw materials, finally condensing the second mixture to remove hydrogen chloride, condensing and recycling hydrogen fluoride to obtain a third mixture flow, and rectifying the third mixture flow to obtain 2, 3, 3, 3-tetrafluoropropene. And 3, 3, 3, 3-tetrafluoropropene. According to the invention, unavoidable process wastes in the prior art are converted into recyclable reaction raw materials, the environmental protection and economic pressure of by-product treatment in the prior art is eliminated, meanwhile, the purpose of continuous flow reaction is effectively realized, and the process control difficulty and the process cost are reduced.

Disclosed in the present invention is a method for producing 2,3,3,3-tetrafluoropropene from 1,1,2,3,3,3-hexafluoropropene, comprising: (a) introducing 1,1,2,3,3,3-hexafluoropropene and hydrogen into a first reactor for a catalytic reaction to obtain a first reaction product; (b) separating the first reaction product to obtain 1,1,1,2,3,3-hexafluoropropane; (c) introducing 1,1,1,2,3,3-hexafluoropropane into a second reactor for a catalytic reaction to obtain a second reaction product; (d) separating the second reaction product to obtain 1,2,3,3,3-pentafluoropropene; (e) introducing 1,2,3,3,3-pentafluoropropene and hydrogen into a third reactor for a catalytic reaction to obtain a third reaction product; (f) separating the third reaction product to obtain 1,1,1,2,3-pentafluoropropane; (g) introducing 1,1,1,2,3-pentafluoropropane into a fourth reactor for a catalytic reaction to obtain a fourth reaction product; and (h) separating the fourth reaction product to obtain a final product of 2,3,3,3-tetrafluoropropene. The present invention has the advantages of being simple in process, low in cost, high in efficiency, green, and environmentally friendly.

The present invention provides a liquid cooling medium and a preparation method and application thereof, belonging to the field of chemical industry. The liquid cooling medium prepared by the preparation method provided by the present invention is a hydrofluoroolefin mixture, comprising two material components, CF3CF2CF2CH=CHCF3 and (CF3)2CFCH=CHCF3. The mixture is spontaneously generated in the preparation process, and there is no need to separate the two, and it can be directly used as a two-phase immersion liquid cooling medium. The preparation method of the present invention is of great significance for preparing candidate working fluids with excellent performance and stable quality for immersion cooling systems, optimizes the synthesis process of hydrofluoroolefins, and provides a full-process preparation process method for raw materials, intermediates and final products. The final product obtained has stable quality and excellent performance. The prepared liquid cooling medium has the advantages of efficient heat dissipation and temperature control, which can achieve the purpose of energy saving and consumption reduction.

The invention relates to production equipment and a production method of 1, 1, 1, 2, 3-pentachloropropane, and belongs to the technical field of preparation of chemical intermediates. According to the invention, 1, 1, 1, 3-tetrachloropropane is adopted as an initial raw material, 1, 1, 1, 2, 3-pentachloropropane is produced through dehydrochlorination and chlorination in the serial tower reactor, and compared with a traditional two-step synthesis process of 1, 1, 1, 2, 3-pentachloropropane, after dehydrochlorination of 1, 1, 1, 3-tetrachloropropane and a 1, 1, 3-trichloropropene chlorination system are coupled, the process flow is shortened; compared with the existing one-pot synthesis process, the reaction is easier to control; a fixed bed catalyst system is adopted, the problems that traditional anhydrous ferric chloride catalyst powder is not easy to add, poor in dispersity and frequent to add are solved, saponification salt-containing wastewater is not discharged, the process is green and environmentally friendly, and the application prospect is wide.

The invention discloses a method for synthesizing p-chloromethyl styrene, which comprises the following steps: carrying out chloromethylation reaction on beta-bromophenylethane, paraformaldehyde and thionyl chloride to generate p-chloromethyl bromophenylethane, then carrying out toluene extraction and static layering, carrying out water washing and alkali washing on an organic phase in sequence, and carrying out reduced pressure distillation to obtain p-chloromethyl styrene. Under the action of strong base, hydrogen bromide is removed through elimination reaction to synthesize crude p-chloromethyl styrene, and the crude p-chloromethyl styrene is acidified and rectified to obtain the product p-chloromethyl styrene. The method solves the problem of generation of a large amount of three wastes in a conventional production route, optimizes the production process, improves the reaction conversion rate from 60-80% to 95% or above, and further improves the yield from 50-60% to 85% or above.

An integrated process for producing E-1,1,1,2,2,5,5,6,6,6-decafluoro-3-hexene and uses of the products produced in this process.

The invention provides an oxyfluoride loaded nickel phosphide catalyst and application thereof. The carrier and the active phase of the oxyfluoride-loaded nickel phosphide catalyst are simultaneously prepared by adopting a'one-pot method '. The oxyfluoride-loaded nickel phosphide catalyst disclosed by the invention shows excellent reaction activity in hydrodechlorination reaction of fluorine-containing chlorohydrocarbon, and compared with a magnesium fluoride-loaded nickel phosphide catalyst obtained by a conventional impregnation method, the activity is obviously improved.

The invention relates to the technical field of catalytic synthesis, in particular to a chloromethylation catalyst, a preparation method of the chloromethylation catalyst and a method for preparing high-purity ortho-position, meta-position and para-position chloromethyl styrene through the chloromethylation catalyst, and the chloromethylation catalyst is prepared by loading sulfonic acid compounds and (or) pyridine compounds and (or) copper salt on a molecular sieve. The method can improve the localization selectivity of chloromethylation. The method for preparing high-purity ortho-position, meta-position and para-position chloromethyl styrene comprises the following steps of: reacting beta-bromophenylethane, paraformaldehyde and lewis acid in the presence of the chloromethylation catalyst to generate chloromethyl beta-bromophenylethane, and then performing elimination reaction under an alkaline condition to generate a chloromethyl styrene crude product; the high-purity ortho-position, meta-position and para-position chloromethyl styrene is obtained after the crude product is rectified, the brand-new catalyst is adopted in the method, the reaction selectivity is enhanced, the process is simple, and industrial production is facilitated.

The invention discloses a method for preparing 3, 3, 3-trifluoro-1-propyne through a two-step method, the 3, 3, 3-trifluoro-1-propyne is prepared through a production system and collected through a material collecting system, and the preparation steps of the production system comprise: (1) in a first solvent, carrying out an addition reaction on 3, 3, 3-trifluoro-1-propylene and ICl to obtain 2-iodo-1-chloro-3, 3, 3-trifluoropropane; (2) in a second solvent, enabling the 2-iodine-1-chloro-3, 3, 3-trifluoropropane to react with alkali to eliminate bimolecular hydrogen halide so as to obtain 3, 3, 3-trifluoro-1-propyne; the temperature of the material receiving system is-196 to-60 DEG C, and the pressure of the material receiving system is-0.03 MPa to normal pressure. The 3, 3, 3-trifluoro-1-propyne is prepared by taking trifluoropropene as a raw material through two-step reaction, and the method has the advantages of simple preparation steps, high reaction yield, small amount of three wastes, low production cost and the like, and is very suitable for industrial production.

The invention provides a process for co-production of HFC-236ea, Z-HFO-1225ye, E-HFO-1225ye and HFO-1234yf, and the process comprises the following steps: reacting hydrogen with HFO-1225ye in the presence of a first catalyst to obtain a first reaction product flow; mixing the first reaction product flow with HFP, and reacting in the presence of a second catalyst to obtain a flow containing HFC-245eb and HFC-236ea; then, a material flow containing HFC-245eb and a material flow containing HFC-236ea are obtained through separation; carrying out a reaction on the material flow containing HFC-236ea in the presence of a third catalyst, washing with water, and extracting to obtain a Z-HFO-1225ye material flow and an E-HFO-1225ye material flow; and reacting the material flow containing HFC-245eb in the presence of a fourth catalyst, and washing and separating to obtain the material flow of HFO-1234yf.

The present invention relates to a process for producing trifluoroethylene in a reactor having a fixed catalyst bed comprising a catalyst, the process comprising the steps of: a) reacting chlorotrifluoroethylene with hydrogen in an aqueous phase in the presence of a catalyst to produce a stream A comprising trifluoroethylene; b) treating said stream A under conditions sufficient to produce a stream D1 comprising 1,1,2-trifluoroethane with a content of less than 15% by weight, based on the total weight of stream D1; and c) recycling stream D1 to step a).