3262 results about "Methyl benzene" patented technology

The invention belongs to the technical field of a new chemical material, and in particular relates to a high-durability super-hydrophobic self-cleaning coating material and a preparation method thereof. The coating material of the invention is prepared by curing and drying nanoparticles with photo-catalytic activity, a low-surface-free-energy polymer and a cross-linking agent at the room temperature, wherein the low-surface-free-energy polymer consists of one or more of polysiloxane fluoride, dimethyl silicone polymer and polyphenylene methyl siloxane, which contain active groups, such as hydroxyl alkoxy group, carbon-carbon double bond, silanol group, siloxy group, and the like; the cross-linking agent is hydrogen-containing silicone oil or aminosilane; and the mass content of the photo-catalytic nanoparticles in the coating ranges from 10 to 60 percent. The coating is formed into a micro-nanostructure by nanoparticle self-organization; a super-hydrophobic self-cleaning coating with lotus effect is prepared from the coating and a cross-linked filming matrix with low surface energy; the persistence of a lotus-shaped super-hydrophobic characteristic of the coating is realized by using the photo-catalytic decomposition characteristic of an organic pollutant for the nanoparticles; and thus the material is suitable for large-area construction and has high weathering resistance andprominent self-cleaning characteristic.

The invention relates to a ketoxime ester photoinitiator, in particular to a ketoxime ester photoinitiator for a photo-curing material. The ketoxime ester photoinitiator has a chemical structural formula as the right, wherein in a R1 structure, n is an integer of between 0 and 5; m is an integer of between 1 and 6; R2 is methyl, phenyl, substituted phenyl, benzyl or substituted benzyl; and R3 is diphenyl sulfide group, substituted diphenyl sulfide group, carbazole group or substituted carbazole group. The ketoxime ester photoinitiator solves the problems of poor application performance and poor thermal stability of the prior OXE-1 ketoxime ester photoinitiator.

The invention discloses a high temperature resistant heat-conducting silica gel sheet and a preparation method thereof. The high temperature resistant heat-conducting silica gel sheet is characterized by comprising the following components in parts by weight: 50-80 parts of vinyl end capped polydimethylsiloxane (PDMS), 20-50 parts of vinyl end capped methyl phenyl silicone oil, 0.3-10 parts of containing hydrogen silicone oil, 2-6 parts of platinum catalyst, 0.2-0.6 parts of inhibitor, 5-100 parts of heat resistant additive and 400-1200 parts of heat-conducting powder. The preparation method of the high temperature resistant heat-conducting silica gel sheet comprises the following steps: firstly, uniformly mixing the vinyl end capped polydimethylsiloxane and the vinyl end capped methyl phenyl silicone oil in a kneading machine; adding the treated or untreated heat-conducting powder and the heat resistant additive which are added in batches, after mixing uniformly, adding the containing hydrogen silicone oil, the inhibitor and the catalyst; and mixing uniformly, and heating and solidifying in a forming machine to form a sheet. The heat resistant silica gel sheet provided by the invention is aged at 250 DEG C for 1000 hours, but still has good usability, and the changes of the hardness and the heat conductivity coefficient are within acceptable ranges.

The present invention provides a compound represented by the formula (I):whereinring A is a ring which is optionally further substituted;R1 is a hydrogen atom or a substituent;R2 is a hydrogen atom or a substituent;R3 is a hydrogen atom or a substituent;R4 is a hydrogen atom or a substituent;R5 is a hydrogen atom or a substituent;R6 is a hydrogen atom or a substituent;X is ═N— or ═C(Z)- (Z is a hydrogen atom or a substituent);when X is ═C(Z)-, Z and R6 are optionally bonded to each other to form, together with the carbon atom bonded thereto, an optionally substituted ring,provided that when X is ═CH—, then R6 is not optionally substituted 2-piperidinyl, excluding N-imidazo[1,2-a]pyridin-2-yl-4-methyl-benzamide, N-imidazo[1,2-a]pyridin-2-yl-benzamide and N-(7-methylimidazo[1,2-a]pyridin-2-yl)-benzamide, or a salt thereof, and a pharmaceutical agent containing same.The compound of the present invention has an ASK1 inhibitory action, and is useful as a pharmaceutical agent such as an agent for the prophylaxis or treatment of diabetes, inflammatory diseases and the like, and the like.

The invention belongs to the field of medicine, and in particular relates to a medical application of 2-([1,1'-biphenyl]-4-yl)-2-oxoethyl 4-((3-chloro-4-methylphenyl) amino)-4-oxobutanoate in a selective histone lysine-specific demethylase 1 (LSD1) inhibitor, especially the application in anti-tumor medicaments. Pharmacodynamic tests indicate that the 2-([1,1'-biphenyl]-4-yl)-2-oxoethyl 4-((3-chloro-4-methylphenyl) amino)-4-oxobutanoate has a remarkable LSD1 inhibiting effect, and has selectivity to homologous proteins MAO-A (monoamine oxidase-A) and MAO-B.

The invention concretely relates to a synthetic technology for pyraclostrobin. The synthetic technology comprises: firstly performing cyclization to obtain 1-(4-chlorophenyl)-pyrazol-3-one, oxidizing the pyrazol ring under the effect of an oxidant to generate 1-(4-chlorophenyl)-3-hydroxypyrazole, then using 2-nitrobenzyl bromide to performing etherification to generate 1-(4-chlorophenyl)-3-[2-(nitrophenyl)methoxy]-1H-pyrazole, then using a reducing agent to perform nitro reducing, so as to generate N-hydroxyl-2-[N'-(4-chlorophenyl)pyrazol-3'-yloxymethyl]aniline, then using ClCO2CH3 to perform N-acylation reaction to generate methyl N-hydroxyl-N-2-{[N'-(4-chlorophenyl)pyrazol-3'-yloxymethyl]phenyl}formate, and finally performing hydroxyl methylation under an alkaline condition to generate pyraclostrobin. The technology enables all operations in the pyraclostrobin preparation process to be relatively controllable, helps to improve the stability of the preparation process and improve the product yield, successfully employs low-cost reagents and substantially reduces production cost, and also the employed reagents are relatively small in toxicity, is relatively beneficial for environment protection, and has no corrosivity on plastic pipes, so that the production safety is improved.

The present invention provides a process for preparing biaryl compounds comprising reacting an arylzinc reagent with an arylchloride in the presence of a nickel catalyst or a palladium catalyst. The present invention specifically provides a process for the preparation of 2-(4'-methylphenyl)benzonitrile comprising reacting a 4-methylphenylzinc reagent with 2-chlorobenzonitrile in the presence of a nickel catalyst or a palladium catalyst.

The invention belongs to the technical field of chemical engineering, and discloses polyether modified organic silicone oil that adopts a comb structure shown in formula (1) and a preparation method and application as a defoamer, and overcomes the service restrictions of conventional organic silicone defoamers. The preparation method comprises the following steps: compounds such as short polyols polydimethyl siloxane or polymethyl phenyl siloxane in which end groups are hydrogen, allyl alcohol polyether, aliphatic esters or alkanes amides that contain end alkenyl are selected as raw materials to synthesize the polyether modified organic silicone oil. According to the invention, as a defoamer, the polyether modified organic silicone oil has good characteristics of self-emulsifying property, self-dispersing property, steady emulsifying property, good defoaming and foam inhibiting performance, high temperature resistance, and acid and alkali resistance.

A composition comprising (S)-5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole and (R)-5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole, enantiomerically enriched in the (S)-enantiomer.

An aminomethylpyridyloxymethyl / benzisoxazole substituted azabicyclic compound, a pharmaceutical composition comprising same, and a method of treating one or more CNS or other disorders, including concurrent treatment of disorders such as schizophrenia and depression.

The invention discloses a method for preparing water-soluble solid styrene / acrylic resin and application thereof. The method prepares the required resin by simultaneously performing free radical polymerization reaction and esterification reaction on an aromatic vinyl unsaturated monomer, an aliphatic vinyl unsaturated monomer, an unsaturated carboxylic acid monomer, fat alkanol, an initiating agent and an alpha-methyl styrene dimer in a reactor. In the method, the alpha-methyl styrene dimer is added as a chain transfer agent to reduce the branching degree and avoid the generation of gel and the blockage of the reactor; and simultaneously, the added fat alkanol performs esterification reaction with acroleic acid to inhibit the esterification reaction between an alcohol ether solvent and the acroleic acid, thus the viscosity of the reaction mixture is controlled effectively, and the finally prepared resin has narrow molecular weight distribution (Mw / Mn is less than 2.0), low molecular weight (Mw is less than 10,000), few organic volatile matters, and good wetting dispersion of pigment, and can be applied to preparing water color ink, coating or oil polish.

A bactericidal preparation in the form of a solution, cream or ointment is disclosed. The preparation comprises a liquid compounded from photosynthesized hydrocarbons, isolates from hydrocarbons, 2-hydroxy-1-isopropyl-4-methyl-benzene (thymol) and butylated hydroxytoluene.

The invention discloses a method for preparing methyl phenyl hydrogen-containing silicone oil by rare earth super acid catalysis, which comprises the following steps of: taking methyl phenyl cyclosiloxane (DnMe, Ph, wherein n=3, 4, 5, 6), dimethyl cyclosiloxane (Dn, wherein n=3, 4, 5, 6), and methylhydrocyclosiloxane (DnH, wherein n=3, 4, 5, 6) as monomers; adding a blocking agent; and selecting rare earth super acids, controlling the reaction temperature, performing polymerization for a certain period under the protection of N2 gas, gradually raising the temperature to 205 DEG C under -0.9 MPa, and extracting low-boiling substances under reduced pressure to obtain the target product. The method has the advantages that: the catalyst can be separated only by filtering without washing neutralization, and the method has low labor intensity, simple process, simple and convenient operation and no pollution, and is convenient for industrialization. The product prepared by the method has good effects in the LED packaging process.

The invention discloses a preparation method of 2-(4-haloethyl) phenyl-2-methyl propionic ester and a synthesis method of bilastine, which comprises the following steps of: carrying out acylation reaction on 2, 2-dimethyl phenylacetate and halogen acetyl halides under the action of catalyst, to generate 2-(4-halogen acetyl) phenyl-2-methyl propionic ester; carrying out kishner-wolff-huang reduction reaction on the 2-(4-halogen acetyl) phenyl-2-methyl propionic ester, to reduce the carbonyl so as to generate the 2-(4-haloethyl) phenyl-2-methyl propionic ester; having condensation reaction with 1-ethoxy ethyl-2-pyridine-4-group benzimidazole by taking the 2-(4-haloethyl) phenyl-2-methyl propionic ester as a midbody to obtain esterified bilastine; and hydrolyzing, to generate the bilastine. The novel synthesis method of the bilastine provided by the invention can easily obtain raw materials, and is simple to operate, lower in cost, environment-friendly, and completely suitable for the industrial production.

A cooling topical cosmetic or dermatological preparation which comprises (1R,2S,5R)-2-isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethyl)cyclohexane carboxamide and / or (1R,2S,5R)-N-(4-cyanomethyl-phenyl)-2-isopropyl-5-methylcyclohexane carboxamide, in combination with menthoxypropanediol.

The invention discloses a polyurethane resin compound ink and preparation method thereof, comprising polyurethane resin, chloride-vinyl acetate resin, solvent, dye and dispersing auxiliary, wherein the solvent comprises methyl benzene, butanone, isopropyl alcohol. The composition of the polyurethane resin compound ink is: polyurethane resin liquor (30% solid content) 25-40%, chloride-vinyl acetate resin 0-4%, dye 5-25%, dispersing auxiliary 0.2-0.5%, methyl benzene 0-20%, butanone 25-35%, isopropyl alcohol 5-15%. The invention provides polyurethane resin compound ink with wide application range, good thermal stability, good adhesion and no aromatics solvent, in order to conquer the lacks such as not environment protection, narrow application range and bad thermal stability.

The invention discloses a method for synthesizing imatinib. The method comprises that: N-(4-methyl-3-3-aminophenyl)-4-(4-methyl-piperazinyl-1-methyl)-benzamide is used as a raw material, and reacts with 4-methyl-(3-pyridyl)-2-pyrimidone under actions of a polypeptide condensation agent and an organic alkali so as to generate the imatinib. The method has the advantages of mild reaction conditions, easy operation, high reaction yield and suitability for industrialized production.

The invention discloses a method for the reaction of isoparaffin and olefin alkyl, which are catalyzed by acidic ionic liquid. The method adopts the isoparaffin and the C4 olefin as the reactant; the cation of the catalyst of the acidic ionic liquid is selected from imidazole cation or naphthyridine cation; the anion is selected from trifluoromethyl acid radical, methyl benzene acid radical or bicarbonate; the reaction solvent is water; the reaction temperature is 40 to 85 DEG C; the reaction pressure is 0 to 4.0 Mpa and the reaction time is 0.25 to 1 hours. The invention has the advantages of mild reaction condition, high activity, high selectivity, easy separation of oil and catalyst, circulating catalyst and low corrosive property.

A topical cosmetic and dermatological preparation for reducing skin reddening which comprises (1R,2S,5R)-2-isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethyl)-cyclohexane carboxamide and / or (1R,2S,5R)—N-(4-cyanomethyl-phenyl)-2-isopropyl-5-methylcyclohexane carboxamide.

Provided herein are processes for the preparation of (S)-(2R,3R,11bR-3-isobuty-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), or a solvate, hydrate, or polymorph thereof.

The invention discloses an alpha-vinyltoluene-styrene-maleic anhydride ternary random copolymer and a preparation method thereof, and belongs to the field of macromolecular polymerization.The preparation method comprises the steps that firstly, a monomer alpha-vinyltoluene, styrene and an initiator are added to a solvent to be dissolved, and the solution is heated to 80 DEG C to 110 DEG C; then, a semicontinuous sample introduction method is adopted for dropwise adding a solution containing maleic anhydride to a reaction system for 1 h to 3 h, and the reaction continues to be carried out for 30 min to 60 min after the solution is dropwise added; after the reaction is finished, the system is subjected to methyl alcohol precipitation, suction filtration and drying, and the alpha-vinyltoluene-styrene-maleic anhydride ternary random copolymer is obtained.The prepared alpha-vinyltoluene-styrene-maleic anhydride ternary random copolymer has the advantages that the content of maleic anhydride is high, and the glass transition temperature is low (low Tg facilitates machine shaping); meanwhile, an alpha-vinyltoluene structural unit is contained in the polymer chain of the ternary random copolymer, depolymerization occurs at high temperature to generate free radicals, and the alpha-vinyltoluene-styrene-maleic anhydride ternary random copolymer can be used as a macroinitiator to be applied to polyolefin grafting and polyolefin melt blending modification.

The invention relates to a catalyst for the alkyl transfer and the conversion of C9 and C9+ heavy aromatics to light aromatics, which mainly solves the existing technical problems of low heavy aromatic conversion rate, low target product selectivity, serious aromatic ring opening phenomena and catalyst requirement for noble metal loading in the process of processing C9 and C9+ heavy aromatics to increase the yield of benzene, methyl benzene and dimethyl benzene in the prior art. By adopting the technical scheme of comprising 20-90 parts of hydrogen nano zeolite and 10-80 parts of adhesive in parts by weight, wherein the mol ratio of SiO2 to Al2O3 in the hydrogen nano zeolite is 8-200, the invention well solves the problems, and can be used in industrial production for the conversion of heavy aromatics to light aromatics and the alkyl transfer.

The present invention hydrogenolyzes alpha, alpha-dimethyl benzyl alcohol in solvent into isopropyl benzene with hydrogen or organic compound as hydrogen source at reaction temperature of 30-100 deg.c under multiphase Pd base catalyst. The present invention has alpha, alpha-dimethyl benzyl alcohol converting rate greater than 96 % and isopropyl benzene selectivity greater than 99 %. The said process may be used in the hydrogenolysis of alpha, alpha-dimethyl benzyl alcohol as the co-product of propylene epoxidation process to prepare propylene oxide with cumene hydroperoxide as oxidant to realize circular utilization of isopropyl benzene. The said technology may be used in recovering propylene from tail gas generated in the process of producing propylene chloride or polypropylene, and may be also used in the propylene oxide producing line.

The invention provides a preparation method of Roxadustat intermediate 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylate (IV), comprising the step of subjecting 2-(1-(3-phenoxyphenyl)ethylimide)dimalonate (III) as a starting material to condensation and cyclization. The preparation method of the Roxadustat intermediate IV has the advantages that material is easy to obtain, operating steps are few, the process is simple, the reaction yield is high, atom utilization rate is high, and the method is easy for industrial production. The reaction general formula is shown in the specification.

A method of forming mixed xylenes from a heavy reformate using a dealkylation-transalkylation system includes the step of introducing both a heavy reformate containing methyl ethyl benzenes and tri-methyl benzenes and that is sufficiently free of toluene and a hydrogen-containing material into the dealkylation stage such that the heavy reformate and the hydrogen-containing material intermingle and contact the hydrodealkylation catalyst. The dealkylation-transalkylation system includes dealkylation, non-aromatic product gas separations and transalkylation stages. Toluene forms from the reaction of methyl ethyl benzenes and hydrogen in the presence of the hydrodealkylation catalyst. The method also includes the step of introducing a dealkylated heavy reformate into the transalkylation stage such that the dealkylated heavy reformate contacts a transalkylation catalyst, forming a transalkylation stage product mixture includes mixed xylenes.

The invention relates to a transalkylation of aromatics and dealkylation method that produces low content of ethyl benzene by-product, and mainly solves the problem that reaction products have high content of the ethyl benzene by-product in the prior art, thus causing low selectivity to target product of dimethyl benzene among mixed carbon-eight products and no selectivity to dealkylation of side chains of arene alkylation. The invention adopts the technical proposal of producing target product of dimethyl benzene through reaction in the fixed reaction bed by adopting carbon-nine and above heavy aromatics and methyl benzene as raw material or adopting carbon-nine and the heavy aromatics as raw material, adopting catalyst containing zeolite with SiO2 / Al2O3 mole ratio of 12-70 by weight proportion, oxide that is selected from at least one of molybdenum, palladium or nickel, oxide that is selected from at least one of ferrum, bismuth, tin or platinum and oxide that is selected from at least one of cerium, lanthanum, magnesium or titanium, and in reaction conditions of weight space velocity of 1.0 to 3.5h<-1>, reaction temperature of 350 - 460 DEG C, reaction pressure of 1.5 to 3.5MPa and molecular proportion of hydrogen / hydrocarbon of 2.0 to 80, thereby properly solving the problem. The method can be used for industrial production of carbon-nine and above heavy aromatics or transalkylation of phenylmethane and dealkylation to reduce content of the ethyl benzene by-product and increase content of the dimethyl benzene product.

The invention provides a group of polyhydroxy stilbene compounds, their preparing process and use for suppressing and eradicating SARS coronavirus. The preparing process comprises, preparing phosphonic ester by reacting multi-alkyl substituted chloro (bromo) methoxyl or pyridine compounds with triethyl phosphate, then reacting phosphonate ester compound with multi-alkyl (oxy) phenylpyridine methyl aldehyde to obtain multi-alkyl (oxy) stilbene compounds. Finally acting with boron tribromide to obtain polyhydroxy stilbene compounds with substituent groups.