1440 results about "Methyl benzene" patented technology

The invention discloses a preparation method of a GLP-1R agonist Orforglipron, which comprises the following reaction steps: carrying out four-step reaction on an oxopiperidine compound (1) and (4-fluoro-3, 5-dimethylphenyl) hydrazine (2) to obtain a compound 8, and carrying out seven-step reaction on 5-bromo-indolecarboxylic acid (9) to obtain a compound 17. Then, the compound 8 and a compound 17 are subjected to an acid amine condensation reaction, and Orforglipron (LY3502970) is obtained. The preparation method is relatively low in cost, easy to operate, relatively short in synthetic route and suitable for industrial production and application, and the total yield can reach 32%.

The invention discloses unsaturated polyester resin for an unmanned aerial vehicle fuselage and a preparation method of the unsaturated polyester resin, and relates to the field of high polymer materials. When the unsaturated polyester resin for the unmanned aerial vehicle fuselage is prepared, a flame-retardant monomer reacts with 2-hydroxy-5-(hydroxymethyl) benzaldehyde to prepare a modified flame-retardant monomer; reacting cellulose with acrylic acid to obtain pre-modified cellulose; the pre-modified cellulose, 1-allyl-1, 1, 3, 3-tetramethyldisiloxane and chloroplatinic acid are subjected to a reaction, and modified cellulose is prepared; maleic anhydride, 5-(1H-imidazole-1-yl)-1, 3-phthalic acid, propylene glycol and the modified flame-retardant monomer are subjected to a reaction, and pre-polyester is prepared; and stirring the pre-polyester, zinc chloride, modified cellulose, benzophenone peroxide and styrene to obtain the anti-aging coating. The prepared unsaturated polyester resin for the unmanned aerial vehicle fuselage has good anti-aging, self-repairing, flame-retardant and self-cleaning performance.

The invention relates to a phosphorus-free zinc-free seawater special-purpose scale and corrosion inhibitor, which comprises, by weight, 20-25% of sulfonic acid modified polyaspartic acid, 8-12% of quaternized chitosan, 5-10% of a sulfonate copolymer, 5-10% of polyepoxysuccinic acid, 1-3% of benzotriazole or methyl benzotriazole, 0.5-1% of sodium tungstate, and the balance of deionized water. According to the formula, traditional corrosion inhibitors such as phosphorus and zinc are completely abandoned, functions are achieved through natural polymer derivatives such as sulfonic acid modified polyaspartic acid and quaternized chitosan, and the scale and corrosion inhibitor has the following environmental protection advantages that the scale and corrosion inhibitor does not contain phosphorus and zinc elements at all, and water eutrophication and heavy metal accumulation caused by a traditional phosphorus and zinc formula are avoided.

The invention discloses a quick-curing polyurethane seamless expansion joint material for roads and a preparation method, and belongs to the technical field of road engineering materials. The material is prepared from polyether polyol, polycaprolactone glycol, a bisphenol A epoxy-polyether block isocyanate terminated prepolymer, a methyl phenyl silicon-boron hybrid hydroxyl chain extender, diphenylmethane diisocyanate, calcium carbonate, wollastonite, a hindered amine anti-aging agent and dioctyl phthalate. Wherein the bisphenol A epoxy-polyether block isocyanate terminated prepolymer is prepared by the following steps: reacting bisphenol A with epoxy chloropropane to generate epoxy resin, reacting with polytetramethylene ether glycol, and introducing isophorone diisocyanate; the methyl phenyl silicon-boron hybrid hydroxyl chain extender is prepared by carrying out hydrosilylation and ethylene glycol reaction on methyl trimethoxy silane, 3-glycidyl ether oxypropyl trimethoxy silane and allylboronic acid pinacol ester; and the methyl phenyl silicon-boron hybrid hydroxyl chain extender is prepared by carrying out hydrosilylation on methyl trimethoxy silane, 3-glycidyl ether oxypropyl trimethoxy silane and allylboronic acid pinacol ester. The material has the advantages of quick curing property, weather resistance and high-temperature stability, and is suitable for road seamless expansion joint scenes.

The present invention relates to a method for the synthesis of a carboxylic diacid, having a 5- or 6-membered heteroaromatic compound optionally comprising an allyl or methylstyrene function, preferably selected from 5- or 6-membered heteroaromatic compounds and comprising at least one heteroatom selected from nitrogen, sulphur and oxygen.

The invention provides a preparation method of 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride, which comprises the following steps: salifying 4-fluoro-3, 5-dimethylaniline serving as a substrate with concentrated hydrochloric acid, reacting with sodium nitrite to prepare a diazo solution, reducing the diazo solution into corresponding phenylhydrazine by using alkaline sodium sulfite as a reducing agent system, and reacting the 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride with the diazo solution to prepare the 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride. And acidizing the 2, 5-dimethyl phenylhydrazine to obtain corresponding phenylhydrazine hydrochloride. According to the preparation method, sodium sulfite which is low in cost and easy to obtain is used as a reducing agent, the defects that metal residues are high, the environment is prone to being polluted and the raw material cost is high due to the fact that a metal reducing agent is adopted when phenylhydrazine hydrochloride is prepared in the prior art are overcome, the reaction is completed in a water phase, no organic solvent is adopted, and the concept of green chemistry is met; and the problems of complicated post-treatment and easy pollution caused by the adoption of an organic solvent can be effectively avoided.

The invention relates to the technical field of water treatment, in particular to a reverse osmosis membrane and a preparation method thereof. The preparation method of the reverse osmosis membrane comprises the following steps: soaking a base membrane in a water phase solution, taking out the base membrane, drying the surface of the base membrane, coating the base membrane with an oil phase solution, carrying out interfacial polymerization reaction, curing, coating with a modifier solution, and drying to obtain the reverse osmosis membrane, the modifying agent comprises 2, 4, 6-tri (4-aminophenyl)-1, 3, 5-triazine-1, 3, 5-tri (4-methyl phenyl) benzene. The successfully grafted COFs can improve the water permeability of the membrane to a certain extent, and also can improve the pollution resistance, acid resistance and oxidation resistance of the membrane, so that the service life of the membrane is prolonged. According to the invention, different effects of the same type of imino COFs introduced to the reverse osmosis membrane are further compared, so that the excellence of the selected imino COFs is highlighted.

The present invention relates to the field of water treatment technology, and more particularly to a kind of reverse osmosis membrane and preparation method thereof.The preparation method of the reverse osmosis membrane includes:Basement membrane is soaked in aqueous phase solution, after taking out surface drying, oil phase solution is coated on basement membrane and carries out interfacial polymerization reaction, after solidification, coating modifier solution, after drying, obtain reverse osmosis membrane;The modifier includes 2,4,6-tris (4-aminophenyl) ‑1,3,5-triazine ‑1,3,5-tris (4-methylphenyl) benzene.The COFs successfully grafted by the present invention can improve the water permeability of membrane to a certain extent, and can also improve the anti-pollution property, acid resistance and oxidation resistance of membrane, and then improve the service life of membrane.The present invention further compares the different effects that the same type of imino COFs are introduced into reverse osmosis membrane, so as to highlight the excellence of the imino COFs selected by the present invention.

The invention relates to the field of fire-resistant oil, in particular to phosphate-based fire-resistant oil with synergistically optimized flame resistance and stability and a preparation method of the phosphate-based fire-resistant oil. The fire-resistant oil comprises base oil and an additive, the base oil is a mixture obtained by esterification of mixed alkylphenol and phosphorus oxychloride; the molar percentage of the mixed alkylphenol is as follows: 4-6% of phenol; 11 to 14 percent of p-methylphenol; 22 to 26 percent of 2, 5-position dimethyl phenol; 0.8 to 1.5 percent of 2, 4-position dimethyl phenol; 2.5 to 4 percent of 2, 3-position dimethyl phenol; 0.4 to 0.6 percent of 4-ethyl phenol; 40 to 48 percent of 3, 5-position dimethyl phenol; 8 to 11% of 3-ethyl phenol; 3 to 5 percent of 3, 4-position dimethyl phenol; the additives comprise an antioxidant, a corrosion inhibitor, an anti-foaming agent and an anti-hydrolysis agent; the addition amount of the antioxidant is 0.05-5% of the total mass of the base oil; the addition amount of the corrosion inhibitor is 0.001%-0.08% of the total mass of the base oil; the addition amount of the anti-foaming agent is 0.001%-0.009% of the total mass of the base oil; the addition amount of the anti-hydrolysis agent is 0.001%-0.005% of the total mass of the base oil. The fire-resistant oil provided by the invention can be safely used under the working conditions of high temperature and extreme pressure.

The invention relates to a preparation method of 3-[(1S, 2S)-1-[5-[(4S)-2, 2-dimethyl oxacyclohexane-4-yl]-2-[(4S)-2-(4-fluoro-3, 5-dimethyl phenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl]-4-methyl-6, 7-dihydro-4H-pyrazolo [4, 3-c] pyridine-5-carbonyl] indol-1-yl]-2-methylcyclopropyl]-4H-1, 2, 3-triazolo [4, 3-c] pyridine-5-carbonyl] indol-1-yl]-2-methylcyclopropyl]-1, 2, 4-triazolo [4, 3-c] pyridine-5- The invention relates to synthesis of 1, 2, 4-oxadiazole-5-one or a salt thereof, and related synthesis intermediate compounds.

The invention relates to the field of water treatment, and discloses a scale and corrosion inhibitor for seawater circulating cooling water, which is prepared from phosphonic acid grafted maleic anhydride-acrylic acid copolymer, hydroxyethylidene diphosphonic acid, amino trimethylene phosphonic acid, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N- The anti-corrosion coating is prepared from the following raw materials: N, N-diethylaminomethyl-benzotriazole, gamma-aminopropyltriethoxysilane, zinc salt and a polyoxyethylene-polyoxypropylene block copolymer. The core of the invention is that all the raw material components form the thermo-sensitive polyelectrolyte compound through a self-assembly process. The compound is stably dispersed at low temperature by utilizing the cloud point effect of the block copolymer, and is subjected to phase change and preferential deposition on a high-temperature heat exchange surface, so that targeted and efficient delivery of various active components is realized. According to the invention, the problems of incompatibility of components and poor stability of a traditional compound agent are solved, the product has excellent storage stability, and efficient and synergistic corrosion and scaling control can be realized under high-temperature and high-salinity working conditions.

The invention discloses a continuous reaction device and method for producing 2-amino-4-methylbenzothiazole, and belongs to the technical field of compound production. The invention relates to a continuous reaction device for producing 2-amino-4-methylbenzothiazole, which comprises a first-stage reaction kettle and further comprises a stirring mechanism arranged in the first-stage reaction kettle and used for stirring chlorine and a mixed solution in the first-stage reaction kettle; the driving mechanism is arranged at the top of the first-stage reaction kettle and is used for driving the stirring mechanism to perform stirring action in the first-stage reaction kettle; the chlorine injection mechanism is connected with the stirring mechanism; the air exhaust mechanism is arranged at the top of the first-stage reaction kettle and is connected with the driving mechanism; the multistage reaction kettles are adopted for continuous operation to eliminate downtime, so that the problem of low production efficiency caused by repeated heating and cooling due to the use of intermittent reaction kettles in the traditional process is solved, the chlorine utilization rate is improved, and the production and processing cost is effectively reduced.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a preparation method and application of N-(3-chloro-4-fluorophenyl)-4-fluoro-3, 5-dimethyl benzenesulfonamide and analogues thereof, and a medicinal composition of the N-(3-chloro-4-fluorophenyl)-4-fluoro-3, 5-dimethyl benzenesulfonamide and the analogues thereof. The method comprises the following steps: dissolving a compound 1 and a compound 2 in an organic solvent, adding an acid-binding agent, carrying out a stirring reaction at 20-100 DEG C, and carrying out TLC detection until raw material fluorescence disappears so as to complete the reaction; and carrying out spin-drying on the reaction liquid, and carrying out crystallization or column chromatography separation on a crude product to obtain N-(3-chloro-4-fluorophenyl)-4-fluoro-3, 5-dimethyl benzenesulfonamide and the analogue of N-(3-chloro-4-fluorophenyl)-4-fluoro-3, 5-dimethyl benzenesulfonamide. N-(3-chloro-4-fluorophenyl)-4-fluoro-3, 5-dimethylbenzenesulfonamide and analogues thereof are used for recovering the physiological level of TERT in senescent tissues, and N-(3-chloro-4-fluorophenyl)-4-fluoro-3, 5-dimethylbenzenesulfonamide and analogues thereof are used for preparing oral pharmaceutical compositions. The N-(3-chloro-4-fluorophenyl)-4-fluoro-3, 5-dimethylbenzenesulfonamide and the analogue thereof can be used for recovering the physiological level of TERT (telomerase reverse transcriptase) of the whole aging tissue and relieving various aging characteristics.

The invention relates to the technical field of bioanalytical chemistry, in particular to a method for simultaneously enriching and separating glycopeptides and phosphopeptides by using a bionic hydrophilic adsorbent, which specifically comprises the following steps: step 1, preparing a polyether-ether-ketone (PEEK) framework by using a fused deposition modeling method (FDM); 2, soaking the obtained PEEK framework in an aqueous solution containing dopamine hydrochloride and tris (hydroxymethyl) aminomethane, and carrying out a reaction; step 3, then, adding a mixed solution containing hyaluronic acid methacrylate, vinyl phosphoric acid, N, N-dimethyl bisacrylamide and phenyl-2, 4, 6-trimethylbenzoyl lithium phosphate into the PEEK framework; in the invention, in the aspect of material preparation, a fused deposition modeling method (FDM) is adopted to prepare a polyether-ether-ketone (PEEK) frame, and the material has good mechanical properties and chemical stability and can bear a series of subsequent complex treatment processes without being damaged.

The invention relates to the field of sealing materials, in particular to a butyl rubber sealing material and a preparation method thereof. Comprising the following components in parts by weight: 50-70 parts of butyl rubber, 30-50 parts of a brominated isobutylene-p-methylstyrene copolymer, 30-50 parts of carbon black, 8-12 parts of an alkyl phenolic resin vulcanizing agent, 3-5 parts of zinc oxide, 1-3 parts of stearic acid, 1-3 parts of an anti-aging agent and 5-10 parts of a plasticizer. The butyl rubber provides ideal air tightness and heat aging resistance, bromine atoms are introduced into the brominated isobutylene-p-methylstyrene copolymer, co-vulcanization with the butyl rubber is achieved, it is ensured that a uniform and stable co-crosslinking network can be formed between the two rubber molecules, and the service life of the rubber is prolonged. The alkyl phenolic resin vulcanizing agent can form a C-C bond with high bond energy with two rubber molecules, so that the thermal aging resistance of the butyl rubber sealing material is effectively improved, the compression set is reduced, and the butyl rubber sealing material with excellent performance is prepared.

The present invention relates to the technical field of mold release agents, and specifically discloses a mold release agent for the integrated die-casting of aluminum alloy automobiles, which comprises the following raw materials in parts by weight: 15-20 parts of fluorinated wax emulsion, 6-8 parts of sodium dodecylbenzenesulfonate, 3-6 parts of Tween 80, 3-5 parts of methylphenyl modified silicone oil, 4-6 parts of graphene regulator, 2-4 parts of nano-silica modifier, 2-4 parts of silane coupling agent, and 10-15 parts of water. The mold release agent of the present invention uses fluorinated wax emulsion in combination with sodium dodecylbenzenesulfonate, Tween 80, and methylphenyl modified silicone as the matrix materials, and through the addition of graphene regulator, nano-silica modifier, and silane coupling agent to coordinate with each other and work together synergistically, with the silane coupling agent as the interfacial agent to enhance the interfacial effect between the raw materials of the system.

The invention relates to a method for synthesizing trifloxystrobin through a one-pot method, and belongs to the technical field of organic synthesis.The method comprises the following steps that 1, E-2-(2-halomethylphenyl)-2-methoxyiminoacetic acid methyl ester, m-trifluoromethyl acetophenone, hydroxylamine hydrochloride or hydroxylamine sulfate and a solvent are added into a reaction flask, then alkali is added, and after addition is completed, a heat preservation reaction is conducted; and Step 2, after the reaction is finished, filtering to remove salt, and concentrating filtrate under reduced pressure to obtain trifloxystrobin. Compared with a traditional synthesis method of the trifloxystrobin, the synthesis method of the trifloxystrobin has the advantages that the 3-trifluoromethyl acetophenone and the E-2-(2-halomethylphenyl)-2-methoxyiminoacetic acid methyl ester are used as raw materials, the trifloxystrobin is directly synthesized by a one-pot method, the reaction route is short, the raw material cost is low, and the synthesis method of the trifloxystrobin by the one-pot method has the advantages that the synthesis efficiency is high, and the synthesis cost is low. The preparation method has the advantages that the preparation of m-trifluoromethyl acetophenone oxime from m-trifluoromethyl acetophenone is not needed, the whole synthesis process is simpler and more efficient, the reaction conditions are mild, and the preparation method is suitable for industrial large-scale production.

The invention belongs to the technical field of near-infrared organic dye synthesis, and particularly discloses a cyanine dye with J aggregation characteristic, J aggregation nanoparticles, and preparation methods and applications of the cyanine dye and the J aggregation nanoparticles. The cyanine dye is 1-ethyl-2-(2-(2-(-3-(2-(1-ethyl-3, 3-dimethyl-1, 3-dihydro-2H-benzo [g] indole-2-subunit) ethylidene)-2-(2, 2, 2-trifluoro-N-(2-methylbenzyl) acetamide) cyclopent-1-ene-1-yl) vinyl)-3, 3-dimethyl-3H-benzo [g] indoleiodised salt, and the structural formula of the cyanine dye is shown in the description. The preparation method is simple, the J aggregation nanoparticles can be prepared by utilizing the unique property of J aggregation, the J aggregation nanoparticles have high light stability and have strong fluorescence emission in a near-infrared second region, and the material prepared by the invention can be used as a contrast agent and is applied to the field of near-infrared second region fluorescence imaging.

The invention discloses a preparation method of a spiro [4.5] trienone compound containing difluoro gamma-lactam, which comprises the following steps: reacting an N-(4-methoxyphenyl)-N-methyl-3-phenylpropanamide compound and an N-allyl-2, 2-difluoro-2-bromo-N-aryl acetamide compound in an argon atmosphere under the action of a photocatalyst and alkali to obtain the spiro [4.5] trienone compound containing difluoro gamma-lactam. And reacting under the irradiation of 467 nm blue light to obtain the spiro [4.5] trienone compound containing difluoro gamma-lactam. The reaction operation is simple and convenient, the product specificity is high, the substrate application range is wide, and the price is low. The invention provides a simple and efficient preparation method of the spiro [4.5] trienone compound containing difluoro gamma-lactam for the first time.

The invention discloses a continuous flow production method of high-purity chlorantraniliprole, and belongs to the technical field of chemical synthesis. The method comprises the following steps: simultaneously pumping a mixed solution containing 3-bromo-1-(3-chloro-2-pyridyl)-1H-pyrazole-5-formic acid, a solvent, an acid-binding agent and 2-amino-5-chloro-N, 3-dimethylbenzamide and a catalyst solution into a mixing unit of a continuous flow reactor I to form a reaction mixture flow; the material flow enters a continuous flow reactor I for condensation reaction to obtain a chlorantraniliprole solution; simultaneously pumping the mixed solution and a quenching agent solution into a continuous flow reactor II, and quenching to separate out crystals; and continuously centrifugally separating the quenching liquid containing the crystals, washing and drying to obtain a chlorantraniliprole refined product. According to the present invention, the full continuous flow process is adopted, the reaction unit and the post-treatment unit are included, the material continuously flows, and when the process is stable, the material composition, the temperature and other parameters in the reactor are only related to the reaction position and do not change with time, such that the production process and the product quality stability are ensured.

The invention discloses a thermo-sensitive paper coating suitable for a backing-paper-free label and a preparation method and application of the thermo-sensitive paper coating, and relates to the technical field of composite materials. According to the thermal-sensitive paper coating provided by the invention, a specific thermosensitive composition is adopted to construct a color developing substance of a color developing layer, 3-(3-methylureido) phenyl-4-methyl benzenesulfonate is compounded with a specific fluorane dye, and the obtained thermosensitive composition can form a covalent bond with silicone oil, so that the silicone oil can be promoted to be cured to form a compact coating, and the thermal-sensitive paper coating has the advantages that the thermal-sensitive paper coating has a good color developing effect; and the silicone oil isolation layer and the thermosensitive composition have excellent binding force, so that the coating provided by the invention has excellent color development performance and higher curing rate, the curing time is as low as 15 seconds or less, the glossiness is 46.7 GU or more, and the dynamic saturation color development performance is 0.96 or more.

This invention relates to N-(3-(6-Amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide drug substance substantially free of a nitrosamine impurity, e.g. the nitrosamine impurity N-(3-(6-amino-5-(2(methyl)(nitroso)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide and novel processes of preparation thereof. The invention further relates to pharmaceutical composition comprising N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide, wherein the composition is substantially free of a nitrosamine impurity, e.g. the nitrosamine impurity N-(3-(6-amino-5-(2(methyl)(nitroso)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide. Pharmaceutical products containing said drug substance and compositions are also disclosed, as well as methods for preparing said drug substance, pharmaceutical compositions and products.

The invention discloses a preparation method of conductive hydrogel based on two liquid metals, which comprises the following steps: by taking 2-acryloyloxyethyl trimethyl ammonium chloride (AETAC) as a monomer, N, N '-methylenebisacrylamide (MBA) as a cross-linking agent and 2-hydroxy-2-methyl propiophenone (HMPP) as a photoinitiator, and combining with eutectic gallium indium (EGaIn) and eutectic gallium indium tin (EGaInSn) liquid metals, preparing the conductive hydrogel based on the two liquid metals. Two different conductive hydrogels are prepared through ultrasonic dispersion and ultraviolet-initiated polymerization. The method is simple in process, and the obtained hydrogel has high conductivity, good mechanical property and biocompatibility and can be widely applied to the fields of flexible electronics, biomedical sensing, wearable equipment and the like.

The invention relates to the technical field of chemistry, in particular to a synthesis process of 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride, which comprises the following steps: by taking 4-fluoro-3, 5-dimethylbromobenzene as a raw material and hydrazine hydrate as a hydrazine source, matching with alkali such as potassium hydroxide, sodium hydroxide or potassium phosphate and the like, reacting at the temperature of 60-80 DEG C to obtain the 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride. The preparation method comprises the following steps: by taking copper or nickel source catalysts such as cuprous bromide, cuprous iodide, nickel salicylate and the like, N, N-bis (2, 6-dimethylphenyl) oxamide as a ligand, hexadecyl trimethyl ammonium bromide as a stabilizer and a dioxane-water mixed system as a solvent, reacting at 80-110 DEG C under the protection of nitrogen, separating a reaction mixed solution after the reaction is finished, and separating the reaction liquid to obtain the target product. And purifying to obtain a finished product of the 4-fluoro-3, 5-dimethyl phenylhydrazine hydrochloride. Therefore, the problems that the synthesis of the 4-fluoro-3, 5-dimethylphenylhydrazine hydrochloride is poor in safety, low in production efficiency, poor in environmental friendliness, small in substrate application range and the like are solved.

The invention relates to the technical field of coatings, in particular to a solvent-free anti-doodling cover agent as well as a preparation method and application thereof. The solvent-free anti-doodling finishing agent is prepared from the following raw materials in percentage by mass: 80 to 95 weight percent of solvent-free methyl phenyl silicone resin, 1 to 5 weight percent of a curing agent, 3 to 8 weight percent of an adhesion enhancer, 0.5 to 3 weight percent of an anti-doodling auxiliary agent and 0 to 6 weight percent of an optional delustering agent. The core is that the adhesion enhancer is an enhanced silane coupling agent and is prepared by carrying out molecular-level chemical bonding on a titanium compound, the silane coupling agent and a self-made antifouling agent. The finishing agent disclosed by the invention has the advantages of high adhesive force, excellent stain resistance, adjustable glossiness and the like, and is suitable for base material protection of various scenes such as building outer walls, household crystal plating and artistic coatings.

The invention discloses a preparation method of deuterated methylamine hydrochloride and a solid-phase continuous flow synthesis system, and relates to the technical field of deuterated synthesis. The preparation method comprises the following steps: adding out-of-phase polykadexide into methyl trifluoromethanesulfonate and 1, 2-dichloroethane for heating reaction, then adding methanol for quenching reaction, washing and drying to obtain an out-of-phase polykadexide type methyl reagent; the method comprises the following steps: adding a heterophase polysulfide-type methyl reagent into a mixed solvent of a polar solvent and heavy water, and carrying out alkali treatment to complete deuteration conversion, so as to obtain a heterophase polysulfide-type deuterated methyl reagent; the preparation method comprises the following steps: dissolving o-phenylsuccinimide in acetonitrile, and adding a heterophase polysulfide deuterium methyl reagent and inorganic alkali to react, so as to obtain N-(1, 1, 1-trideuterium methyl) benzo-succinimide; the preparation method comprises the following steps: hydrolyzing N-(1, 1, 1-trideuterium methyl) benzo-succinimide and hydrochloric acid in an aqueous solvent to obtain deuterated methylamine hydrochloride. The preparation method is simple, the deuterium source is cheap, the atom utilization rate is high, the deuteration rate is high, and the production cost is low.

The invention belongs to the technical field of organic matter synthesis, and particularly relates to a preparation method of 2-(2 '-hydroxy-3'-methallyl-5 '-methylphenyl) benzotriazole, in particular to a preparation method of cresol triazole trisiloxane. The invention relates to a preparation method of 2-(2 '-hydroxy-3'-methallyl-5 '-methylphenyl) benzotriazole, which comprises the following steps: mixing cresol trozole, methyl allyl chloride, Lewis acid and a first polar organic solvent, and carrying out Friedel-Crafts alkylation reaction to obtain the 2-(2'-hydroxy-3 '-methallyl-5'-methylphenyl) benzotriazole. When the 2-(2 '-hydroxy-3'-methallyl-5 '-methylphenyl) benzotriazole is prepared, the conventional Claisen rearrangement reaction is replaced, and the 2-(2'-hydroxy-3 '-methallyl-5'-methylphenyl) benzotriazole is prepared by adopting the Friedel-Crafts alkylation reaction of cresol trozole, so that the safety risk of process operation is reduced.

The invention provides a preparation method of a (S)-5-(2, 2-dimethyl tetrahydro-2H-pyran-4-yl)-N-methyl-N-phenyl-1H-indole-2-formamide compound, which comprises the following steps: by taking a compound 1 as an initial raw material, reacting the compound 1 with a boric acid ester reagent to obtain a boric acid ester compound 2; the method comprises the following steps: by taking a compound 3 as an initial raw material, reducing carbonyl through enzyme catalysis to obtain a compound 4, then protecting alcoholic hydroxyl through a sulfonylation reagent to obtain a compound 5, and finally, directly coupling the compound 5 with a compound 2 under the action of a catalyst to obtain a target product compound 6. The whole process is low in experimental condition requirement, simple to operate, high in yield and suitable for process amplification.

The invention discloses a preparation method of 2-chloro-4-(4-fluoro-2-methylphenyl)-5-aminopyridine as an elinnetin intermediate, and belongs to the technical field of medicine synthesis. According to the invention, cheap and easily available 3-nitro-4-hydroxypyridine is used as an initial raw material, and the 2-chloro-4-(4-fluoro-2-methylphenyl)-5-aminopyridine is synthesized at low cost and high yield through the steps of halogenation, coupling, hydroxylation, reduction, condensation and the like. The raw materials used in the whole process are simple and easy to obtain, the reaction conditions are milder, and the reaction route is short. According to the invention, the Suzuki coupling reaction is firstly carried out, and then the hydroxylation of the pyridine 2 position is carried out, so that the use of an anhydrous reagent and harsh anhydrous reaction conditions are effectively avoided, and the reaction cost is remarkably reduced. In addition, the method is easy and convenient to operate, good in stability, high in total yield and suitable for industrial large-scale production.

The invention belongs to the field of rubber additives, and particularly relates to an anti-aging agent as well as a synthesis method and application thereof. RT base and a phenol compound are used as raw materials for synthesis under the action of a catalyst; the phenol compound is a mixture of phenol and o-methylphenol. According to the invention, RT base (p-aminodiphenylamine) is used as a precursor and reacts with phenol or o-methylphenol in the presence of a catalyst to produce the anti-aging agent. Salt-containing waste water is not generated in the precursor production process, and compared with hydroquinone serving as a precursor, the precursor has the obvious cost advantage and the environment-friendly advantage.