157 results about "Cumene" patented technology

The invention provides a bissanthin aromatic ring bay region C-H nucleophilic substitution reaction method and application thereof, and belongs to the field of organic synthesis methodology. According to the reaction, bissanthin is used as a raw material, dichloromethane and acetonitrile are used as solvents, and the bissanthin is oxidized by nitrite hexafluorotellurate and respectively reacts with nucleophilic reagents such as carbon anions, oxygen-containing reagents, sulfur-containing reagents, chlorine-containing reagents, nitrogen-containing reagents, phosphorus-containing reagents and cyano groups in one step to synthesize a series of bissanthin bay area modified functionalized products; when the reaction method is further applied to the nucleophilic substitution reaction of two molecules, namely perylene (Perylene) and N, N '-di (1, 3-diisopropyl benzene)-3, 4, 9, 10-perylene dicarboximide (PDI), good universality is shown, and the reaction method can be applied to the nucleophilic substitution reaction of two molecules, namely perylene (Perylene) and N, N'-di (1, 3-diisopropyl benzene)-3, 4, 9, 10-perylene dicarboximide (PDI). The method is mild in reaction condition, does not need to introduce transition metal as a catalyst, is easy in product separation and purification, and has the advantages of low cost, high efficiency and greenness; the series of functionalized derivatives constructed by the method can provide important intermediates for synthesis of larger polycyclic aromatic hydrocarbon molecules of the system; the method has a good industrial production prospect.

The invention discloses an MOFs adsorbent of cumene and a preparation method and application thereof, and belongs to the technical field of adsorbent preparation, and the preparation method comprises the following steps: step 1, preparing an MIL-101 adsorbent; 2, the MIL-101 adsorbent is soaked in a thiocyanate solution for 10 min to 30 min, centrifugation, washing and drying are conducted, and the MOFs adsorbent of isopropyl benzene is obtained. The adsorption capacity of the MIL-101 adsorbent post-treated by the sodium thiocyanate to cumene gas is remarkably improved. Due to the introduction of sodium thiocyanate, a new functional group is grafted, and a new adsorption site is introduced, so that the adsorption capacity of the adsorbent on cumene gas is remarkably improved.

The present invention provides a preparation method for high-content 2-trifluoromethyl-4-heptafluoroisopropyl aniline. In the presence of dithionous acid, a solvent, and a catalyst, 2-trifluoromethyl aniline and 2-bromoheptafluoropropane undergo a reaction and post-treatment to obtain high-content 2-trifluoromethyl-4-heptafluoroisopropyl aniline, wherein the catalyst is selected from phosphoric acid, pyrophosphoric acid, hypophosphorous acid, metaphosphoric acid, phosphorous acid, pyrophosphorous acid, hydrobromic acid, hydrogen bromide gas, hydrogen chloride gas or sodium bisulfite. The preparation method of the present invention is simple to operate, has mild chemical reaction conditions, achieves a primary reaction conversion content of 96% or above under good reaction conditions, has few post-treatment steps, requires no rectification, achieves a final product content of 98% or above, achieves a total reaction yield of 93% or above, is easy for industrial production, and has good prospects for application.

The invention discloses a method for synthesizing a chlorfenapyr bisamide intermediate by a one-pot method, which comprises the following steps: by taking aniline as an initial raw material, reacting the aniline with 2-bromoheptafluoropropane under the action of a catalyst and an acid-binding agent to generate 4-heptafluoroisopropylaniline, distilling to recover excessive 2-bromoheptafluoropropane after the aniline is completely converted, and separating the 2-bromoheptafluoropropane from the 4-heptafluoroisopropylaniline to obtain the chlorfenapyr bisamide intermediate. Adding bromotrifluoromethane into the reaction liquid to react to obtain 2-trifluoromethyl-4-(heptafluoroisopropyl) aniline, then carrying out oxidation-reduction reaction on the dropped hydrogen peroxide and excessive sodium hydrosulfite, and after the sodium hydrosulfite is completely consumed, reacting to obtain 2-trifluoromethyl-4-(heptafluoroisopropyl) aniline; and carrying out benzene ring bromination reaction on dropwise added hydrogen peroxide, the brominating agent in the reaction liquid and the 2-trifluoromethyl-4-(heptafluoroisopropyl) aniline to obtain the 2-bromo-4-(heptafluoroisopropyl)-6-(trifluoromethyl) aniline, wherein the brominating agent in the reaction liquid and the 2-trifluoromethyl-4-(heptafluoroisopropyl)-6-(trifluoromethyl) aniline are subjected to benzene ring bromination reaction. The method is simple in process, high in yield, low in raw material cost and suitable for industrial production.

The invention discloses a light internal partition wall board and a preparation process thereof, and belongs to the technical field of building materials. The light internal partition wall board is prepared from the following main raw material components in parts by mass: 500 to 700 parts of slag washed sand, 1400 to 1600 parts of cement, 40 to 50 parts of flame-retardant light filler, 10 to 24 parts of flame retardant, 15 to 60 parts of air entraining agent, 8 to 24 parts of water reducing agent and 330 to 750 parts of water. Wherein the flame-retardant light filler is obtained by sequentially reacting expanded polystyrene particles with bis (pinacolato) diboron, 4-bromo-3-isopropyl benzoic acid and triisopropyl phenyl phosphate; the water reducing agent is prepared from polyvinyl alcohol; the prepared light internal partition wall board is high in compressive strength, good in fire resistance and light in mass.

The invention belongs to the field of catalyst technology application, and relates to a preparation method of 3-(3-isopropyl phenyl) butyraldehyde. The method comprises the following steps: by taking m-isopropenyl isopropyl benzene, organic alkali and H2 as raw materials, adding a prepared high-activity rhodium catalyst and a corresponding phosphine ligand, and optimizing a reaction process to obtain high-yield and high-purity 3-(3-isopropyl phenyl) butyraldehyde. The production method has the advantages of simple steps, mild reaction conditions, high yield of the obtained 3-(3-isopropyl phenyl) butyraldehyde, realization of solvent-free reaction, great cost saving, and suitableness for large-scale industrial production.

The invention discloses a method for producing epoxypropane with low energy consumption by a cumene method. Comprising the following steps: S1, carrying out a reaction on cumene and oxygen-containing gas in a gas-liquid bubbling bed reactor to obtain an oxidation solution with the concentration of cumene hydroperoxide being 30-70%, and removing impurities to obtain dried cumene hydroperoxide, S2, carrying out a reaction on the dried cumene hydroperoxide and propylene in a tubular fixed bed reactor to obtain an epoxide material, recovering excessive propylene from the epoxide material, and recovering the propylene from the epoxide material to obtain the cumene hydroperoxide. S3, carrying out hydrogenolysis reaction on the crude alpha, alpha-dimethyl benzyl alcohol and hydrogen, so as to convert the crude alpha, alpha-dimethyl benzyl alcohol into crude cumene; s4, heavy component removal, light component removal and alkali washing are conducted on the crude cumene, impurities in the crude cumene are removed, and then the crude cumene is returned to the step S1. According to the method, the oxidation depth of the cumene in the oxidation unit is increased, the circulation amount of the cumene is greatly reduced, the energy consumption of the device is greatly reduced, and the economical efficiency of the device is improved.

Hoses include inner tube, a reinforcement layer disposed outwardly from the inner tube, and a cover layer disposed outwardly from the reinforcement layer, and the cover layer and / or inner tube is based on a cured composition formed from a mixture containing a blend of chlorinated polyethylene (CPE) and cross-linkable oxidized high density polyethylene (oxidized HDPE), where the CPE and oxidized HDPE are blended in a CPE:oxidized HDPE weight ratio of from 10:1 to 1:1, and a peroxide curing system. The peroxide curing system used in some compositions according the disclosure include alpha-alpha-bis(t-butylperoxy)diisopropylbenzene and trimethylolpropane trimethacrylate.

The invention belongs to the technical field of synthesis and application of medical intermediates, and particularly relates to a preparation method of a dimethyl isobenzofuranone compound, which is characterized in that 2-isopropyl benzoic acid is subjected to intramolecular oxidative cyclization reaction under the action of catalytic amount of hydrochloric acid and oxygen in an organic solvent under an illumination condition to obtain the dimethyl isobenzofuranone compound. The preparation method of the dimethyl isobenzofuranone compound provided by the invention is green, efficient and mild in condition.

The present invention relates to the technical field of cumene hydroperoxide production, specifically to cumene hydroperoxide and its preparation method and application. Cumene is mixed with a composite stabilizer, hydrogen peroxide and TiO 2 -PW catalyst are added, and the reaction is carried out at 65 °C for 1.5 hours under nitrogen protection; then the temperature is raised to 85 °C and the reaction is carried out for 4 hours; the obtained reaction solution is cooled to 40 °C, and the catalyst is recovered by filtration; the aqueous phase is removed by liquid separation, and the organic phase is washed with 5% sodium bicarbonate solution until neutral; then the unreacted cumene is removed by vacuum distillation, and then treated by molecular sieve adsorption decolorization and ethanol recrystallization, and cumene hydroperoxide is obtained after drying. By using a composite stabilizer, the present invention effectively inhibits the decomposition of hydrogen peroxide, improves the stability of the reaction system, reduces the occurrence of side reactions, and improves the production efficiency.

A system can be used to reduce the impurities present in a styrene monomer product distilled from a pyrolysis oil. The system can include a fractionation train downstream from a depolymerization unit. The fractionation train may include four fractionation columns in series and produce a styrene monomer product stream comprises at least 99.0 wt% styrene and 300 ppm or less cumene.

The invention relates to a green synthesis method of 2, 4-dicumyl phenol. The invention belongs to the field of synthesis of medical intermediates. The invention aims to solve the technical problems that the raw materials are non-renewable, thermal runaway is easily caused by high-temperature reaction, the energy consumption is high and the content of 3-substituted by-products is relatively high in the existing synthesis method of 2, 4-dicumyl phenol. The method comprises the following steps: adding vanillin into an electrolyte, and carrying out electrochemical deoxidation in a proton exchange membrane electrolytic cell by taking a titanium-based DSA electrode as an anode to obtain o-methoxyphenol; according to the method, o-methoxyphenol and cumene are subjected to a free radical coupling reaction in a flowing electrochemical reactor in the presence of a homogeneous electron transfer catalyst by taking a titanium-based DSA electrode as an anode, and high-purity 2, 4-dicumyl phenol is obtained through extraction and distillation after the reaction is finished. According to the method, the raw materials are 100% renewable, strong acid and high temperature are avoided, hazardous waste emission is avoided, few trisubstituted by-products are generated, and industrial production can be carried out.

The invention discloses a preparation method of a cyclopofol intermediate B (cyclopropyl [2-hydroxy-3-(propyl-2-yl) phenyl] ketone) and cyclopofol. The preparation method comprises the following steps: esterifying 2-isopropyl phenol serving as a starting material and cyclopropylformyl chloride to obtain a compound A, carrying out rearrangement reaction on the compound A through aluminum trichloride to obtain an intermediate compound B, carrying out ylide reaction on the intermediate compound B and methyltriphenylphosphorus bromide to obtain a compound C, and carrying out recrystallization on the compound C to obtain a compound D; splitting (R)-(+)-1-phenylethyl isocyanate to obtain a compound E ({[(1R)-1-phenylethyl] amino} methanoic acid-6-[(1R)-1-cyclopropylethyl]-2-(propyl-2-yl) phenyl ester with a single configuration, wherein {[(1R)-1-phenylethyl] amino} methanoic acid-6-[(1R)-1-cyclopropylethyl]-2-(propyl-2-yl) phenyl ester; the purity of the finished cyclopofol finished product obtained through refining can reach 99.9%, the cost is low, operation is easy and convenient, and industrial production is easy.

The present invention provides a benzene column pressure control system, a cumene production system and a method, specifically relating to the technical field of cumene production. The benzene column pressure control system includes: a benzene column, a reflux drum and a disturbance device. The reflux drum is arranged at the top of the benzene column and is communicated with the benzene column. The disturbance device includes a gas pipeline and a spraying device. The spraying device is installed at the bottom of the reflux drum. One end of the gas pipeline is communicated with the spraying device, and the other end is communicated with disturbance gas. The disturbance gas enters the spraying device through the gas pipeline and is sprayed into the reflux drum by the spraying device, so that the light hydrocarbon components in the system are discharged along with the disturbance gas. By adopting the cumene production system including this control system, it can adapt to propylene with different purities, ensure the safe and stable operation of the benzene column pressure, and at the same time reduce the investment cost and operation cost.

The invention belongs to the technical field of preparation methods of fine compounds, and particularly relates to a preparation method of 3-(3-isopropyl phenyl) butyraldehyde. The method comprises the following steps: by taking a mixed material of m-isopropenyl cumene and phenylcyclopentene as a raw material, carrying out carbonylation reaction under the action of a catalyst; the catalyst is a noble metal carbonyl catalyst; after the reaction is finished, a reaction product is rectified, and isopropenyl isopropyl benzene is obtained; and carrying out formylation reaction on the product, and separating to obtain the 3-(3-isopropyl phenyl) butyraldehyde. The method has the advantages that raw material sources are simplified, physical and chemical properties of products obtained after different components react are changed through different reaction conditions of the different components in the reaction process, the purposes of separation, removal and purification are easily achieved, then the target product is obtained through the hydroformylation reaction, high purity is kept, and the method is suitable for industrial production. And moreover, the conversion rate is more thorough, and the cost can be greatly reduced compared with the existing production technology economically.

A liquid organic peroxide composition including: (a) di(tert-butylperoxy)diisopropylbenzene; and (b) at least one aliphatic organic peroxide selected from the group consisting of 2,5-dimethyl-2,5-di(tert-butylperoxy)hexane, di(tert-amyl) peroxide, di(tert-butyl)peroxide, and 2,5-dimethyl-2,5-di(t-butylperoxy)hexyne-3. The organic peroxide composition is a homogenous liquid at ambient temperature.

The invention discloses a model compound-based lipid oxidation free radical specificity induction and detection method, which comprises the following steps: catalyzing a model compound (cumene / cumene hydroperoxide) or a lipid sample by using iron ions (Fe < 2 + > / Fe < 3 + >) with different valence states, and specifically inducing to generate cumene alkyl free radicals, cumene peroxide free radicals and cumene alkoxy free radicals; the method comprises the following steps: reacting a free radical trapping agent PBN with active free radicals to generate a stable PBN-free radical adduct; the adduct is separated and qualitatively identified by utilizing HPLC-TOF / MS (High Performance Liquid Chromatography-Time of Flight / Mass Spectrometry), and is accurately quantified by HPLC-UV (High The method has the advantages that three key free radicals can be specifically distinguished and quantified, the sensitivity is high, the repeatability is good, the method is suitable for free radical analysis from a model system to a complex grease sample, and a reliable analysis means is provided for research on a lipid oxidation mechanism.

The utility model belongs to the technical field of storage devices, and particularly relates to a storage device based on bis (tert-butylperoxy) diisopropyl benzene. Comprising a storage tank, a discharge valve is arranged at the bottom of the storage tank, and a chemical material device is connected below the discharge valve. And the material melting device comprises a pressurizing initial melting device and a melting device which are connected in sequence. The pressurizing primary melting device comprises a pressurizing primary melting bin, a primary melting heating sleeve is arranged outside the pressurizing primary melting bin, the melting device comprises a melting bin, and a melting heating sleeve is arranged outside the melting bin. And the pressurized primary melting bin is connected with a nitrogen pipeline. And the pressurizing initial melting device is connected with the melting device through a connecting pipeline. According to the material melting device, through nitrogen pressurization and heating, solid materials are rapidly melted into thick slurry, the thick slurry is conveyed downwards through a connecting pipeline to a melting bin to be further heated into liquid, and the liquid is conveyed to a production device to serve as a raw material to participate in production. Rapid heating and melting are achieved, raw materials in the whole storage tank do not need to be melted, the heating process is continuous, and efficiency is greatly improved.

The invention belongs to the technical field of catalysis, and relates to a water-resistant low-temperature catalyst and a preparation method and application thereof.The surface of a Mn / Al2O3 catalyst is doped with Cr oxide, and then a certain amount of 2, 4, 6-triisopropyl benzoic acid (Y-CrMn / Al2O3) is grafted to the surface of CrMn / Al2O3. The water-resistant low-temperature catalyst has excellent catalytic activity and water poisoning resistance, 2, 4, 6-triisopropyl benzoic acid is grafted on the surface of the chromium and manganese doped Al2O3 catalyst, the water poisoning resistance of the catalyst in 5% vol water vapor wet flue gas is improved, and the activity of the catalyst is reduced by about 3%. The catalyst is especially suitable for low-temperature catalytic oxidation of VOCs in moisture-containing flue gas, and has a wide application prospect. The catalyst is prepared by adopting conventional dipping, calcining and surface grafting processes, the process is simple, the reproducibility is good, and the catalyst shows good stability and water-resistant stability in long-term use.

The application provides a long-term high-temperature thermal-oxidative aging resistant flame-retardant polypropylene insulating material and a preparation method and application thereof, and preparation raw materials of the long-term high-temperature thermal-oxidative aging resistant flame-retardant polypropylene insulating material include polypropylene grafting antioxidant modified material, EMA resin, halogen-free flame retardant, auxiliary antioxidant, metal ion passivator and lubricant; and preparation raw materials of the polypropylene grafting antioxidant modified material include polypropylene, hindered phenol monomer, methyl methacrylate and di-tert-butyl peroxide isopropyl benzene. The flame-retardant polypropylene insulating material provided by the application solves the problems of spraying and precipitation caused by high antioxidant addition amount when the polypropylene material meets the long-term high-temperature thermal-oxidative aging resistance requirement from the root, and the degree of PP thermal-oxidative aging degradation and negative chain reaction in the later stage are further reduced as the PP tertiary carbon hydrogen is consumed in the grafting process, and the long-term high-temperature thermal-oxidative aging resistance of the material as a whole is further improved.

The utility model belongs to hydrogen peroxide cumene production technical field, concretely relates to a kind of hydrogen peroxide cumene production with oxidation device of multistage dispersion structure. The hydrogen peroxide cumene production with oxidation device of multistage dispersion structure, including cumene storage tank, cumene storage tank is connected with preheater by feed pump, and preheater is connected with cumene feed inlet in upper portion of oxidation tower;Oxidation tower top is connected with tail gas condenser by gas phase pipeline, and tail gas condenser bottom is connected with gas-liquid separation tank. The hydrogen peroxide cumene production with oxidation device of multistage dispersion structure of the utility model is matched by air section feeding and internal structure, increases mass transfer area, improves oxidation reaction rate and selectivity;Recovery reaction heat preheats raw material, stabilizes temperature field, reduces energy consumption;Tower top separates tail gas droplet, recovers cumene, guarantees process stability, improves device safety.

The present invention provides a method for recycling cumene in a process of preparing propylene oxide by a cumene co-oxidation method. The method comprises: rectifying and separating the cumene in the reaction solution of α,α-dimethyl benzyl alcohol hydrogenolysis, and removing impurities by means of alkali washing. By controlling the proportion and content of cyclohexanol and phenol therein, the reuse times and recycling rate of recycled cumene can be greatly improved, and the cost of production of the propylene oxide by the cumene co-oxidation method can be effectively reduced.

The invention relates to a peroxide ester initiator containing degradable disulfide bonds and application of the peroxide ester initiator to preparation of degradable branched polymers, and belongs to the field of functional initiator design. According to the preparation method, tert-butyl (cumene) hydrogen peroxide and lipoic acid are taken as raw materials, tert-butyl peroxide (cumene) lipoic acid ester containing disulfide bonds capable of being subjected to ring-opening polymerization is synthesized to serve as an initiator, vinyl monomers are initiated to be subjected to self-initiation free radical polymerization reaction, and the degradable branched polymer is successfully obtained. The peroxide ester functional initiator containing the degradable disulfide bond is synthesized by adjusting the amount-of-substance ratio of the initiator to the polymeric monomer and adjusting the branching degree of the polymer, and the degradable branched polymer is successfully prepared by the initiator under the conventional free radical polymerization condition without adding the branched monomer. The reaction method is simple and easy to implement, the monomer conversion rate is high, the branching degree of the polymer is controllable, and the branched polymer can be degraded and is high in applicability to synthesis of branched polymers from various types of monomers.

The application provides a preparation method of high-content 2-trifluoromethyl-4-heptafluoroisopropylaniline, in which 2-trifluoromethyl aniline and 2-bromine heptafluoropropane are reacted in the presence of hydrosulfite, a solvent and a catalyst to obtain high-content 2-trifluoromethyl-4-heptafluoroisopropylaniline through reaction and post-treatment; the catalyst is selected from phosphoric acid, pyrophosphoric acid, hypophosphorous acid, metaphosphoric acid, phosphorous acid, pyrophosphorous acid, hydrobromic acid, hydrogen bromide gas, hydrogen chloride gas or sodium bisulfite. The preparation method is simple in operation and mild in chemical reaction conditions; under the preferred reaction conditions, the conversion content reaches more than 96% in one reaction, the post-treatment steps are few, rectification is not needed, the content of the final product is more than 98%, the total reaction yield is more than 93%, the industrial production is easy, and the method has a high application prospect.

The invention provides a novel preparation method of 2-(3-isopropyl phenyl) propane-2-alcohol, which comprises the following steps: reacting m-diisopropylbenzene, air and alkali liquor to obtain an oxidation reaction solution, reducing the oxidation reaction solution, and then washing, rectifying and de-weighting to obtain a 2-(3-isopropyl phenyl) propane-2-alcohol product. The method has the advantages of convenience, rapidness, high selectivity and high practical value.

The invention provides a system and a method for detecting impurities in bis (tert-butylperoxy) diisopropyl benzene, the system comprises a detection cavity, an inert gas purging pipeline, a microfluidic sampling device, a spectrum detection module, a micro chromatography-mass spectrometry module and a control and data processing module, through the modules, real-time monitoring and early warning are realized, the detection safety is improved, and the detection accuracy is improved. Results are fed back in real time in each step of sample collection, spectrum preliminary screening and mass spectrometry, any detected abnormal data can immediately trigger a control signal through real-time monitoring, and potential risks caused by accumulation of peroxide or other harmful impurities in the production process are effectively avoided. The spectrum detection module and the micro chromatography-mass spectrometry module are combined, efficient cooperation is achieved in the detection process, the detection time is shortened to the maximum extent, inert gas protection is conducted through the inert gas purging pipeline, decomposition or reaction of peroxide in bis (tert-butylperoxy) diisopropyl benzene is avoided, and higher safety guarantee is provided for detection.

The invention discloses a method for preparing cumyl hydroperoxide by using Joule heat to drive cumyl benzene oxidation, which comprises the following steps: immersing a conductive forming carbon material into cumyl benzene, connecting the conductive forming carbon material with direct current until a system reaches a preset oxidation reaction temperature, and introducing oxygen to carry out oxidation reaction, the cumyl hydroperoxide is obtained. The method for preparing cumene hydroperoxide by using Joule heat to drive cumene oxidation has the advantages of high heat transfer efficiency, high temperature rise speed, accurate temperature control, low reaction energy consumption, easiness in catalyst separation and the like, and is suitable for large-scale industrial application.

The invention belongs to the technical field of separation of a mixture of isopropyl benzene and ethylbenzene, and particularly relates to a method and a production system for separating the mixture of isopropyl benzene and ethylbenzene in an adsorption-rectification coupling mode, and the method comprises the following steps: enabling the mixture of isopropyl benzene and ethylbenzene to pass through an adsorption-elution tower to obtain isopropyl benzene with the mass fraction greater than or equal to 99.5%; and eluting the saturated adsorption-elution tower by using an eluent to obtain an eluent and ethylbenzene mixture, separating the eluent and ethylbenzene mixture through a side rectifying tower to obtain ethylbenzene with the mass fraction greater than or equal to 99% and the eluent, and recycling the eluent. The method provided by the invention solves the problems of low purity, high energy consumption and low yield caused by direct rectification separation of isopropyl benzene and ethylbenzene, and has good economic benefits and environmental benefits.

The present invention relates to the technical field of cumene oxidation, and specifically to a cumene oxidation reaction system and method, comprising an oxidation tower and a gas-liquid separator; the oxidation tower is sequentially provided with a bubbling reactor and a microbubble generator from top to bottom; the bottom of the oxidation tower is connected to a gas supply device and a liquid supply device, respectively, and the top is connected to the gas-liquid separator; the top of the gas-liquid separator is connected to a condensing device and the gas supply device, respectively, and the condensing device is connected to an oxygen analysis device; a liquid circulation device is provided between the bottom of the gas-liquid separator and the bottom of the oxidation tower, for circulating the liquid inside the gas-liquid separator to the inside of the microbubble generator. Utilizing this system, the efficiency of cumene oxidation to produce cumene hydroperoxide can be effectively improved, and the system has the advantages of high cumene hydroperoxide production rate, high selectivity, and high safety.

The invention discloses a method for preventing sodium sand agglomeration in a thiophene metallization process. The adsorption effect of disodium isopropylbenzene is reduced by properly increasing the proportion of oleic acid; the reaction temperature is strictly controlled, and the temperature is controlled in a lower temperature range in the process of dropwise adding the electron transfer reagent and in the period of continuing the reaction after dropwise adding, so that mutual permeation among sodium particles with low melting points is avoided, and meanwhile, the sodium sand particles are prevented from being adsorbed by the disodium cumene under proper conditions; by strictly adding materials according to the material adding sequence, adding thiophene, tetrahydrofuran and sodium sand at one time, dropwise adding an electron transfer reagent, strictly controlling the dropwise adding speed of the electron transfer reagent, slowly dropwise adding, and properly prolonging the dropwise adding time of alpha-methylstyrene, the generation of a large amount of disodium cumene caused by excessive reactants of the electron transfer reagent is avoided. According to the operation of the method, the liquid does not turn red in the whole process, and sodium sand particles continuously and uniformly become small and finally become flocculent insoluble substances; the method effectively solves the problem of sodium sand agglomeration.