468 results about "Hydrobromic acid" patented technology

This disclosure relates to administration of a combination of: 1) about 100-110 mg, about 104-106 mg, or about 105 mg or less of bupropion hydrochloride, or a molar equivalent amount of the free base form or another salt form of bupropion; and 2) about 40-50 mg, about 44-46 mg, or about 45 mg or less of dextromethorphan hydrobromide, or a molar equivalent amount of the free base form or another salt form of dextromethorphan in certain patient populations, such as patients having moderate renal impairment, patients receiving a concomitant strong CYP2D6 inhibitor, patients who are known CYP2D6 poor metabolizers, those in need of an NMDA antagonist that does not cause dissociation, and those at risk of QT prolongation.

The invention relates to the technical field of organic synthesis, and discloses a preparation method of bromo-pyrrole nitrile. The method comprises the following steps: (1) mixing p-chlorophenylglycine, acetonitrile, trifluoroacetic acid and a catalyst, then dropwise adding acyl chloride and carrying out acylation reaction, and after the reaction is completed, purging with an inert gas; (2) under the inert gas, mixing the mixture obtained in the step (1) with inorganic salt, then dropwise adding 2-chloroacrylonitrile, carrying out cyclization reaction, and separating a liquid phase from the obtained mixture; and (3) under the inert gas, mixing the liquid phase obtained in the step (2), hydrobromic acid and hydrogen peroxide, carrying out a bromination reaction, then extracting with acetonitrile to obtain an acetonitrile layer, then removing the acetonitrile, and then carrying out cooling crystallization to obtain the bromo-pyrrolenitrile. According to the technical scheme, the reaction yield is high, different solvents do not need to be frequently replaced, and the solvents can be recycled.

The invention provides an electrolyte for improving the interface stability of a four-electron aqueous zinc-iodine battery, and belongs to the technical field of zinc-iodine battery electrolyte additives, the electrolyte comprises N, N-dihydroxyethyl glycine, zinc sulfate, an additive and water; in the electrolyte, the concentration of the N, N-dihydroxyethyl glycine is 0.5 + / -0.2 mol / L; the molar ratio of the additive to the zinc sulfate is 1: 3; the additive comprises any one of methyl triethyl ammonium chloride, betaine hydrochloride and triethylamine hydrobromide. The electrolyte can enhance the interface stability of the electrode electrolyte, improve the cycling stability and electrochemical performance of the aqueous zinc-iodine battery, inhibit side reactions, and improve the safety and reliability of the battery. The invention also provides a high-capacity aqueous zinc-iodine battery.

Crystalline hydrobromide salt of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT HBr).

The invention relates to the technical field of flow batteries, in particular to a bromine-chromium flow battery system. According to the invention, one or more of hydrobromic acid, hydrochloric acid and hydroiodic acid are used as additives, and Br2 and the additives in the electrolyte are complexed to form Br2X <-> to exist in the electrolyte, so that battery performance reduction caused by overflow and precipitation of bromine gas in the positive electrolyte is avoided, and the efficiency of the bromine-chromium flow battery is improved; meanwhile, the flow battery system further relieves battery part aging caused by bromine overflow and capacity fading caused by bromine loss through the gas conveying device, so that the service life of the bromine-chromium flow battery is prolonged.

The invention provides a method for determining a non-deuterated substance in a deuterated drug deuteromidevir hydrobromide, which makes up the technical blank that no corresponding non-deuterated substance quantitative detection method for deuteromidevir hydrobromide exists at present. Compared with other methods for detecting non-deuterated substances in deuterated compounds, the method provided by the invention has the advantages of no satellite peak interference, similar relaxation time and chemical environment of two quantitative peaks, reduction of quantitative peak integral error, high accuracy (the recovery rate is 98.5-101.1%), high sensitivity (the limit of quantitation is lower than 0.05%), simple operation, no need of accurate weighing, no need of any standard substance, low cost and the like. And the universality is high.

The invention relates to a method for detecting high-content zinc element in ore. The detection method comprises the following steps: adding a zinc-containing ore sample into a mixture of ammonium fluoride, hydrobromic acid, hydrochloric acid, nitric acid and perchloric acid, dissolving, taking melt with hydrochloric acid to obtain a solution to be detected, drawing a zinc standard working curve, detecting the strength of the solution to be detected, and calculating the content value of the zinc element on the zinc standard working curve according to the strength value. According to the scheme provided by the invention, the operation is simple and convenient and the detection result is accurate when the high-content zinc element in the ore is detected.

The invention belongs to the technical field of X-ray detection, and particularly relates to lead-free two-dimensional double perovskite, a preparation method of the lead-free two-dimensional double perovskite and an X-ray detector manufactured based on the perovskite. The lead-free two-dimensional double perovskite is applied to X-ray detection. According to the preparation method, histamine dihydrochloride (C5H11Cl2N3Cl), silver chloride (AgCl) and bismuth trioxide (Bi2O3) are mainly used as raw materials, a mixed solution of hydrobromic acid (HBr) and hypophosphorous acid (H2PO2) is used as a solvent, a single crystal material ((C5H9N3) 2AgBiBr8 single crystal) is prepared through a hydrothermal method, and the two sides of the single crystal are coated with silver paste to serve as electrodes, so that the direct type X-ray detector is obtained. The preparation method disclosed by the invention has the characteristics of simplicity, easiness in operation, low requirement on equipment, low cost, low energy consumption and suitability for expanded production.

The invention discloses a method for preparing spermidine. The method comprises the following steps: dissolving oxalyl chloride and a base in a first solvent, slowly adding 4-bromo-1-butylamine hydrobromic acid, and reacting to obtain 2-((4-bromobutyl)amino)-2-oxoacetyl chloride; adding a base to the reaction solvent of the obtained 2-((4-bromobutyl)amino)-2-oxoacetyl chloride, and slowly adding 3-bromo-1-propylamine hydrobromic acid to obtain N 1 ‑(4‑Bromobutyl)‑N 2 ‑(3‑bromopropyl)oxalamide; 1 ‑(4‑Bromobutyl)‑N 2 ‑(3‑bromopropyl)oxalamide, benzylamine and a base are added to a second solvent to react to obtain 8‑benzyl‑1,4,8‑triazacyclododecane‑2,3‑dione; 8‑benzyl‑1,4,8‑triazacyclododecane‑2,3‑dione is added to an acid for hydrolysis to obtain N 1 ‑(3‑Aminopropyl)‑N 1 Benzylbutane-1,4-diamine; N 1 ‑(3‑Aminopropyl)‑N 1 Benzylbutane-1,4-diamine is added to Raney nickel / methanol, and hydrogen is passed through the reaction to obtain crude spermidine, which is then distilled to obtain pure spermidine. The preparation method of the present invention is easy to operate and safe, easy to industrial-scale production, and has a high conversion rate of spermidine and high product purity.

The invention particularly relates to a preparation method of a high-fluidity vortioxetine hydrobromide alpha crystal form. According to the technical scheme, vortioxetine hydrobromide is dissolved in an organic solvent with the volume being 5-10 times that of the vortioxetine hydrobromide, insoluble substances are filtered out, and polyvinylpyrrolidone with the mass being 1-2.5 times that of the vortioxetine hydrobromide is added into filtrate; and feeding the solution into pre-cooled purified water containing seed crystals for crystallization, filtering, and drying to constant weight. The obtained vortioxetine hydrobromide is in an alpha crystal form, is spherical, has the particle size of less than 15 microns and the specific surface area of more than 1600 m < 2 > / kg, and is high in dissolution rate, good in fluidity, high in yield and easy to industrialize.

This disclosure provides crystalline forms of N-((1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl)-4-fluoro-7-methyl-1H-indole-2-carboxamide. N ((1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl)-4-fluoro-7-methyl-1H-indole-2-carboxamide hydrochloride, and N-((1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl)-4-fluoro-7-methyl-1H-indole-2-carboxamide hydrobromide, pharmaceutical compositions comprising these crystalline forms, methods of making these crystalline forms, and methods of treating a disease, condition, or disorder in a subject comprising administering these crystalline forms to the subject.

The invention relates to a preparation method of rotigotine, which solves the technical problems of unreasonable reaction steps and higher production cost in the prior art, and comprises the following steps: carrying out chiral amination reduction reaction on 5-methoxy-2-tetralone, chiral phosphate, pinacol borane and p-methoxyaniline to obtain a compound 1; reacting the compound 1 with bromopropane to obtain a compound 2; reacting the compound 2 with ceric ammonium nitrate to obtain a compound 3; dissolving the compound 3 in hydrobromic acid, and reacting to obtain a compound 4; and carrying out a reaction on the compound 4 and 2-thiophene ethyl methanesulfonate to obtain a crude product rotigotine. The method can be applied to the field of preparation of rotigotine.

The embodiment of the invention provides a method for separating a benzenediol isomer and 5-indanol in a phenol-containing crude product, which comprises the following steps: rectifying the phenol-containing crude product to obtain mixed benzenediol with a distillation range of 240-300 DEG C; the method comprises the following steps: carrying out etherification reaction on mixed benzenediol with the distillation range of 240-300 DEG C obtained by rectifying crude phenol rectification residues by adopting etherification reaction: carrying out etherification reaction on the mixed benzenediol and an etherification reagent under the action of a catalyst, recovering excessive etherification reagent in a reactant after the reaction, and rectifying to obtain etherate; wherein hydroquinone dialkyl ether with the purity not lower than 98% is crystallized and purified by adopting a melt crystallization method or a solvent crystallization method; and / or reducing a part of etherate by using mixed trimethylbenzene and hydrobromic acid to obtain various benzenediol isomers and 5-indanol.

The present application provides a method for extracting lithium from salt lakes. The method comprises the following steps: (1) subjecting concentrated brine to ammonia vapor magnesium precipitation treatment to obtain a magnesium-removed filtrate and filter residue; (2) mixing the filter residue with hydrobromic acid, adjusting the pH to precipitate boric acid, and performing solid-liquid separation to obtain a filtrate and boric acid; (3) evaporating and concentrating the filtrate obtained in step (2), performing aeration treatment after drying treatment, and performing water immersion separation treatment to obtain a lithium-rich solution and magnesium oxide; (4) mixing the lithium-rich solution and lithium carbonate to perform a solid-phase transformation reaction, and filtering to obtain a purified lithium salt solution and calcium carbonate. The method of the present application can separate boron, magnesium, and calcium-lithium in one step, and further calcium removal can separate calcium and lithium, which is beneficial to obtaining high-purity lithium carbonate and reducing lithium loss caused by the adsorption of lithium by magnesium hydroxide colloid.

The invention relates to the technical field of biology, in particular to an inducer, a reagent combination and application of the inducer in preparation of anisodamine. The inducing agent comprises silver nitrate, acetylsalicylic acid and methyl jasmonate, the components of the inducing agent cooperate with one another, compatibility is high, synergistic interaction can be achieved, and the efficiency of the inducing agent for rapidly converting hyoscyamine into anisodamine is further improved. According to the invention, a suspension cell culture technology is adopted, and an optimized callus culture medium, a precursor substance hyoscyamine and an inducer are combined, so that compared with an initial material anisodamine tanguticum used by an existing anisodamine hydrobromide raw material medicine, the anisodamine hydrobromide raw material medicine has the advantages of short growth cycle, stable content and components, environmental protection and no damage to natural resources; the invention provides a new approach for obtaining a starting material for the production of an anisodamine hydrobromide bulk drug, and is suitable for popularization and application.

The invention belongs to the technical field of flame retardants, and particularly relates to a melamine hydrobromide flame retardant and a preparation method thereof. The flame retardant disclosed by the invention has a core-shell structure, the core is hydroxylated melamine hydrobromide subjected to surface modification by a silane coupling agent, and the shell is melamine resin synergistically enhanced by ammonium polyphosphate and oxidized cellulose nanofibrils; through silanization treatment, core-shell interface combination is enhanced, and space-time synergy of gas phase and condensed phase flame retardance is achieved through a composite shell; the obtained flame retardant is high in thermal stability in a polymer matrix, the limit oxygen index of a composite material can be remarkably increased after the flame retardant is added, and the flame retardant has a wide application prospect in the field of flame retardance of high polymer materials through a UL-94 V-0 grade test.

The invention relates to the technical field of composite current collector materials, and provides a preparation method of a PET-based composite copper foil. The method comprises the following steps: (1) dropwise adding concentrated sulfuric acid into a xylene dispersion liquid of a poly (gamma-benzyl-L-glutamate) nanorod, spraying onto the surface of a PET film, standing for reaction, and performing vacuum drying; (2) spraying an acetic acid solution of hydrobromic acid to the surface of the PET film, standing for reaction, washing and vacuum drying; (3) soaking the PET film in ammonia water, soaking the PET film in a silver nitrate solution, and soaking the PET film in a formaldehyde solution; and (4) chemical copper plating. The method not only can improve the interface bonding between the PET base film and the copper plating layer, but also has good environmental protection property and economical efficiency.

The invention belongs to the field of medicines, and particularly discloses a cystamine derivative impurity of tiagliptin hydrobromide and a control method thereof, and the control method comprises the following steps: dissolving a starting material tetrahydrothiazole in an organic solvent, washing with water, stirring, standing, separating liquid, retaining an organic phase, and spin-drying to obtain purified tetrahydrothiazole. Compared with the prior art, the method has the advantages that cysteamine and cystamine impurities in the thiazolidine are reduced by washing and extracting the starting material thiazolidine, so that the content of cystamine derivative impurities in the tiagliptin API is less than 0.1%, the product purity is effectively improved, and the quality consistency of tiagliptin raw material medicines in multi-batch production is better; repeated recrystallization of API is avoided, the yield is increased to 80% from 36%, and the production cost is reduced; the operation is simple and easy to realize.

The present invention provides a preparation method for high-content 2-trifluoromethyl-4-heptafluoroisopropyl aniline. In the presence of dithionous acid, a solvent, and a catalyst, 2-trifluoromethyl aniline and 2-bromoheptafluoropropane undergo a reaction and post-treatment to obtain high-content 2-trifluoromethyl-4-heptafluoroisopropyl aniline, wherein the catalyst is selected from phosphoric acid, pyrophosphoric acid, hypophosphorous acid, metaphosphoric acid, phosphorous acid, pyrophosphorous acid, hydrobromic acid, hydrogen bromide gas, hydrogen chloride gas or sodium bisulfite. The preparation method of the present invention is simple to operate, has mild chemical reaction conditions, achieves a primary reaction conversion content of 96% or above under good reaction conditions, has few post-treatment steps, requires no rectification, achieves a final product content of 98% or above, achieves a total reaction yield of 93% or above, is easy for industrial production, and has good prospects for application.

The invention discloses a catalyst system and application thereof, and a production method and system of aromatic carboxylic acid. The catalyst system comprises a main catalyst containing metal ions and a co-catalyst, the metal ions comprise cobalt and manganese, and the cocatalyst is selected from hydrobromic acid and / or bromine-containing inorganic salt. When the aromatic carboxylic acid is produced, under the action of an organic acid aqueous solution and the catalyst system, aromatic hydrocarbon and oxygen-containing gas are sequentially subjected to oxidation and deep oxidation reaction, and the aromatic carboxylic acid is prepared. When the catalyst system is used for oxidation production, not only can the conversion rate of reactant aromatic hydrocarbon and the selectivity of product aromatic carboxylic acid be improved, but also a production process system of the aromatic carboxylic acid can stably run for a long time, and the catalyst system has excellent industrial application value. The aromatic carboxylic acid is produced by adopting oxidation and deep oxidation reactions in a cascade manner, the reaction conditions are mild, and the method is suitable for industrial production.

The invention discloses preparation and application of an amido-functionalized polyionic liquid catalyst, vinyl imidazole hydrobromide and N-(4-vinyl) benzyl diethylamine are used as monomers, N, N '-methylene bisacrylamide is used as a cross-linking agent, and the amido-functionalized polyionic liquid catalyst is prepared through a free radical copolymerization method. The imidazole / amido functionalized cross-linked PILs with multiple active sites are prepared by one-step synthesis through a hydrothermal polymerization method. The catalyst has catalytic active sites of amido, imidazolyl and Br, so that the catalyst can efficiently catalyze the cycloaddition reaction of CO2 and epoxide at 80 DEG C and normal pressure in the absence of a solvent and a co-catalyst.

The invention belongs to the field of medicines, and discloses a continuous rectification process and equipment for brominated alkane. The continuous rectification equipment for brominated alkane comprises an extraction device and a rectification device, and the extraction device comprises a hydrobromic acid extraction tower, a water washing extraction tower and an alkali washing extraction tower; the rectification device is double-tower rectification equipment and comprises a light component removal tower and a refining tower; or the rectification device is single-tower separation equipment and comprises a refining tower. The invention also discloses a continuous rectification process for brominated alkane, which comprises the following steps of: performing three-stage extraction and refining to obtain a brominated alkane product. (1) compared with the traditional process, the brominated alkane rectification process adopts a combined process of three-stage extraction and two-stage refining to recover alcohol substances, the treatment capacity is large, the purity of a brominated alkane product can reach the medicine field, and the product yield is higher; according to the method, water in brominated alkane is effectively removed by adopting extraction standing oil-water separation and azeotropic light component removal, drying is not needed, and no solid waste is generated in the system.

The invention provides a one-pot preparation method of ethyl 4-bromobutyrate, which is characterized by comprising the following steps: step 1, adding gamma-butyrolactone into an organic solvent, and carrying out reflux water separation while dropwise adding a hydrobromic acid aqueous solution, step 2, detecting the content of gamma-butyrolactone, if the content is less than 0.5% by mass fraction, carrying out step 3, and if the content is more than 0.5% by mass fraction, carrying out step 4; 3, dropwise adding absolute ethyl alcohol, continuing to carry out reflux water separation until the water content is less than 0.2% by mass fraction to obtain a crude product solution of the ethyl 4-bromobutyrate, and carrying out distillation and rectification to obtain a purified ethyl 4-bromobutyrate solution, and 4, detecting the water in the system, and if the water content is less than 0.5% by mass fraction, carrying out the step 3, and if the water content is less than 0.5% by mass fraction, carrying out the step 4. If not, continuously supplementing and dripping the hydrobromic acid aqueous solution, continuously carrying out reflux water diversion, and repeating the step 2; when the water content is 0.5% or above by mass fraction, continuing to carry out reflux water separation, and repeating the step 2.

This invention relates to the field of chemical synthesis technology and discloses a method for preparing 2,5-furandicarboxylic acid from fructose, comprising the following steps: preparing reaction system A containing fructose, an organic bromide, a solid acid catalyst, and water; performing a dehydration reaction to separate the solid acid catalyst and obtain a fructose dehydration reaction solution; preparing reaction system B containing the fructose dehydration reaction solution, a co-oxidant, an oxidation catalyst, and acetic acid; performing an oxidation reaction under an oxidizing gas atmosphere; separating the product to obtain 2,5-furandicarboxylic acid. This invention utilizes a co-oxidant, which can reduce the requirement for fructose concentration in the one-pot preparation of 2,5-furandicarboxylic acid while ensuring the yield and purity of FDCA, thereby improving production efficiency. Furthermore, it reduces or even eliminates the use of hydrobromic acid in the oxidation reaction, thus reducing corrosion to equipment.

The invention discloses a method for detecting genotoxic impurities in vortioxetine hydrobromide orally disintegrating tablets. The method comprises the following steps: mixing phosphate buffer and methanol, wherein the volume ratio of the phosphate buffer to the methanol is 1-20:80-100, to obtain a solvent; grinding the vortioxetine hydrobromide orally disintegrating tablets, adding the mixture into the solvent for dissolution, filtering, and obtaining a test solution; then detecting the test solution by an HPLC method to obtain the content of the genotoxic impurities in the flutioxetine hydrobromide orally disintegrating tablets; the structural formula of the genotoxic impurities is shown in formula (I): The detection method of the invention has accurate and reliable results, is simple and convenient to operate, is rapid, has high stability, good repeatability and durability, can effectively break the difference between solubility and stability, has a recovery rate close to 100%, and has no significant degradation trend of nitrosamine impurities.

The invention discloses a method for detecting an N-nitroso compound in vortioxetine hydrobromide, and the N-nitroso compound is 2, 2 '-(nitroso amino) bis-acetonitrile. According to the method, a high performance liquid chromatography is adopted, an octadecyl silane bonded silica gel filler chromatographic column and an ultraviolet detector are adopted, a mobile phase A is 0.05% phosphoric acid aqueous solution, a mobile phase B is methanol, and gradient elution is adopted. The method has good specificity and sensitivity.

The invention relates to the technical field of cable preparation, and provides a high-strength low-voltage power cable, which comprises a cable core, and an aluminum-plastic composite wrapping tape, a mica wrapping tape and a sheath layer which sequentially wrap the cable core from inside to outside, the sheath layer comprises the following substances: an ethylene-vinyl acetate copolymer, linear low-density polyethylene resin, a modified flame retardant, montmorillonite, a light stabilizer, a lubricant, an antioxidant and polyethylene grafted maleic anhydride; wherein a preparation process of the modified flame retardant comprises the following steps: mixing melamine hydrobromide, absolute ethyl alcohol and deionized water, uniformly stirring, raising the temperature, adding a composite additive, stirring to react, cooling to room temperature after the reaction is finished, and drying to obtain the modified flame retardant. The preparation method has the beneficial effects that the surface of the melamine hydrobromide is coated, so that the antagonism between the melamine hydrobromide and the light stabilizer is reduced; in addition, long-chain alkyl groups and flame-retardant groups contained in the flame-retardant polyester resin further improve the flame-retardant effect and the mechanical property of the material.

The present disclosure relates to administering in certain patient populations a combination of: 1) about 100 to 110 mg, about 104 to 106 mg, or about 105 mg or less of bupropion hydrochloride or a molar equivalent of bupropion in the form of a free base or in the form of another salt; and 2) dextromethorphan hydrobromide or a molar equivalent of dextromethorphan in the form of a free base or another salt, in the amount of about 40 to 50 mg, about 44 to 46 mg, or about 45 mg or less, the patient populations such as patients suffering from moderate renal injury, patients receiving companion strong CYP2D6 inhibitors, patients known as CYP2D6 weak metabolites, patients in need of NMDA antagonists that do not cause dissociation, and patients at risk of QT prolongation.

The present application relates to a trace neodymium doped phenethylamine lead bromide monocrystal capable of simultaneously enhancing light yield and shortening decay time and application thereof, which solves the technical problem that the prior art is difficult to simultaneously improve light yield and shorten luminescence decay time. The trace neodymium doped phenethylamine lead bromide monocrystal capable of simultaneously enhancing light yield and shortening decay time is prepared by the following steps: 1) weighing; phenethylamine hydrobromide, lead bromide and neodymium bromide are weighed and placed in a glass bottle; the molar ratio of the phenethylamine hydrobromide, lead bromide and neodymium bromide is 2:1:(0.02-0.05); 2) obtaining a precursor solution; N,N-dimethylformamide is added to the glass bottle, heated and stirred until completely dissolved to obtain a precursor solution; 3) obtaining a crystal; the precursor solution is filtered and placed in a glass beaker for crystallization to obtain a neodymium doped phenethylamine lead bromide monocrystal; through adjustment of the crystal band structure by neodymium, the radiation recombination rate is improved.

The present invention relates to a method for preparing p-bromotoluene by using toluene catalyzed by niobium. A supported niobium oxide catalyst is used, toluene, hydrobromic acid and hydrogen peroxide are added into a reactor, and the product p-bromotoluene is obtained by reaction at a certain reaction temperature. The process is simple to operate, has a high utilization rate of bromine atoms and little pollution. The niobium catalyst used has a simple preparation method, is stable in strong acid, can be recycled multiple times without deactivation, has high product selectivity, good catalytic effect, and has good industrial application prospects.