124 results about "Hydrobromic acid" patented technology

The invention belongs to the technical field of flame retardants, and particularly relates to a melamine hydrobromide flame retardant and a preparation method thereof. The flame retardant disclosed by the invention has a core-shell structure, the core is hydroxylated melamine hydrobromide subjected to surface modification by a silane coupling agent, and the shell is melamine resin synergistically enhanced by ammonium polyphosphate and oxidized cellulose nanofibrils; through silanization treatment, core-shell interface combination is enhanced, and space-time synergy of gas phase and condensed phase flame retardance is achieved through a composite shell; the obtained flame retardant is high in thermal stability in a polymer matrix, the limit oxygen index of a composite material can be remarkably increased after the flame retardant is added, and the flame retardant has a wide application prospect in the field of flame retardance of high polymer materials through a UL-94 V-0 grade test.

The invention provides a preparation method of N, N-diisopropylethylamine based on a liquid-phase compression synthesis process, which comprises the following steps: mixing ethanol with hydrobromic acid with specified concentration, and carrying out reactive distillation treatment in the presence of a phase transfer catalyst to generate bromoethane; p-bromoethane and diisopropylamine are subjected to a liquid phase addition and compression combination reaction, and a reaction mixture is obtained; and sequentially neutralizing, distilling, condensing and filtering the reaction mixture to obtain the N, N-diisopropylethylamine, so as to solve the problems that the existing preparation method of the N, N-diisopropylethylamine is high in energy consumption, high in operation risk, large in pollutant discharge amount, low in by-product resource utilization rate, low in cost and the like. The safety is poor; the energy efficiency is low; and by-products cannot be recycled.

The application provides an Ag etching solution, a preparation method and application thereof. The Ag etching solution comprises the following components in a weight ratio: 40-80 parts of inorganic acid; 10-50 parts of organic acid; 0.05-1.5 parts of corrosion inhibitor; 0.1-2 parts of chelating agent; 1-7.5 parts of buffer; and 30-50 parts of ultrapure water. The application further discloses a preparation method of the Ag etching solution and application thereof in the field of etching ITO-Ag-ITO composite layers. The inorganic acid is selected from one or more of phosphoric acid, sulfuric acid, carbonic acid, boric acid, hydrobromic acid, iodic acid, hypoiodous acid, hydrofluoric acid and nitric acid. The inorganic acid is preferably phosphoric acid and nitric acid. The Ag etching solution has a stable etching rate for ITO-Ag-ITO, and is not damaged to the insulating layer and photoresist, and can be used in the OLED pixel electrode manufacturing process, and the Ag layer is not provided with burrs and is not shrunk after etching.

Disclosed in the present invention is a method for directly preparing a phenol and an aldehyde or a ketone from an alkyl aromatic hydrocarbon as a raw material on the basis of a selective carbon-carbon bond oxidative cleavage reaction. The method is carried out on the basis of the following steps: mixing an alkyl aromatic hydrocarbon as represented by general formula (I) with a photocatalyst, hydrobromic acid, and an organic solvent and enabling the mixture to react under the conditions of oxygen as an oxidant and light irradiation to simultaneously prepare a phenol compound as represented by general formula (II) and a ketone or aldehyde compound as represented by general formula (III). In the present invention, bulk alkyl aromatic hydrocarbons are used as raw materials for reaction to produce phenol, aldehyde, and ketone organic chemical raw materials. Compared with traditional synthesis methods, the present invention has many advantages such as inexpensive and readily available catalysts, mild reaction conditions, simple operation, good selectivity, and high safety, is suitable for large-scale synthesis of phenols, p-cresol, cyclohexanone, etc., and exhibits wide application prospects.

The invention provides a rapid and high-precision determination method for reduction-state Os isotope. The method comprises the following steps: selecting a sample to be detected and carrying out ultrafine crushing; weighing the ground to-be-detected sample, and sealing and dissolving the sample; taking out the dissolved to-be-detected sample, and adding isometric hydrobromic acid to convert oxidation state Os into reduction state Os; carrying out acid removal and constant volume on the reduced-state Os solution; establishing a cup structure for static determination of the Os isotope, and performing MC-ICP-MS determination of the reduction state Os isotope according to the cup structure. According to the present invention, the dissolved to-be-tested sample is creatively taken out, and the isometric hydrobromic acid is added so as to convert the oxidation state Os into the reduction state Os, such that the memory effect can be substantially reduced, the efficiency can be improved, the research cost and the research time can be reduced when the MC-ICP-MS is adopted to rapidly and precisely measure the Os isotope, and the method is suitable for the mass sample test.

The application discloses a preparation method of o-bromoanisole. The o-bromoanisole is synthesized through three steps, anisole is used as raw material, p-sulfonic anisole is first synthesized, 2-bromo-4-sulfonic anisole is synthesized on the basis, and finally, the sulfonic group is removed to obtain o-bromoanisole. Since anisole is used as raw material, the problems of multiple by-products, low yield and low purity existing in the synthesis path of phenol are avoided. Meanwhile, all the raw materials of the application have low cost, the process steps are simple, and etherification is not needed. Meanwhile, since anisole is used as raw material, hydrobromic acid and hydrogen peroxide can be used in the intermediate step, the hydrobromic acid is oxidized to generate bromine, the reaction rate can be controlled, the reaction efficiency is improved, the waste of bromine is reduced, the purity of the prepared product can reach 99.4%, the yield reaches 96.26%, and the product can be applied on a large scale in industry.

The present invention provides a salt of a triazine compound which has an inhibitory action against aldosterone synthase and is useful as a drug, and especially as a drug for preventing or treating primary aldosteronism and the like, a crystal thereof, and a method for producing the same. Specifically, the present invention provides a pharmaceutically acceptable salt of 3-[4-[[trans-4-(acetamino)cyclohexyl]carbamoylmethyl]piperazin-1-yl]-5-(p-tolyl)-1,2,4-triazine, wherein the salt is hydrobromide, sulfate, succinate, or tosylate, and the like.

The present application relates to a method for increasing the adhesion of a slide, belonging to the technical field of biological medicine, to solve at least one of the problems in the prior art, such as poor adhesion of mycobacterium tuberculosis on the slide, easy to drop the slide in subsequent operation, serious loss of mycobacterium tuberculosis, and influence on the diagnosis rate of pulmonary tuberculosis. The dextromethorphan hydrobromide tablets and the flaxseed gum can generate a high molecular water-soluble polymer with strong positive charge adhesion under the action of a catalyst, that is, the binder described in the present application. Since mycobacterium tuberculosis is the pathogen causing tuberculosis, its surface has a large number of negative charges. Once the mycobacterium tuberculosis with negative charges on the surface contacts the binder containing a large number of positive charges, the surface of the mycobacterium tuberculosis will be quickly wrapped by the binder, forming a firm adhesion layer, and the problem of easy dropping of the slide will not occur during staining and subsequent detection.

The application provides a preparation method of low-impurity vonerogefumate. The application provides a method for removing impurities A-E in the preparation of vonerogefumate, wherein vonerogefumate is reacted with hydrobromic acid to obtain vonerogefumate hydrobromide, and the method specifically comprises the following steps: (1) dissolving vonerogefumate and hydrobromic acid in a solvent; (2) cooling or directly precipitating a solid; and (3) separating to obtain vonerogefumate hydrobromide. The method can remove impurities A-E which are difficult to remove by a recrystallization refining method, and the method has good selectivity for impurities A-E. The application provides an impurity D, a preparation method thereof and application of the impurity D as an impurity control sample of vonerogefumate.

The application provides a synthesis method of 6-bromo-2-chloro-3-nitropyridine and relates to the technical field of organic synthesis. 2-amino-3-nitro-6-chloropyridine is reacted with a hydrobromic acid acetic acid solution to obtain 2-amino-3-nitro-6-bromopyridine, which is diazotized to obtain 6-bromo-2-hydroxy-3-nitropyridine, and then the 6-bromo-2-hydroxy-3-nitropyridine is reacted with a chlorinating reagent to obtain 6-bromo-2-chloro-3-nitropyridine. The synthesis method of 6-bromo-2-chloro-3-nitropyridine has the advantages of easy availability of raw materials, low price, mild reaction condition, simple process, high economic benefit, suitability for large-scale production, and the like, can solve the current situation of high price of 6-bromo-2-chloro-3-nitropyridine, and can play a positive role in the promotion of downstream products of 6-bromo-2-chloro-3-nitropyridine.

The invention discloses an analysis method for determining halogenated alkane impurities in tigliptin hydrobromide, and relates to the technical field of quality analysis. In order to solve the problem of detection of halogenated alkane impurities in tigliptin hydrobromide, the invention provides a convenient, efficient and accurate detection method. The method comprises the following steps: preparing a test solution and an impurity reference solution, and detecting by adopting a gas chromatographic method; the method can be used for accurately determining the content of halogenated alkane in tigliptin hydrobromide, plays a guiding role in development of a synthesis process, and contributes to establishment of quality standards of tigliptin hydrobromide bulk drugs.

The invention provides an X-ray luminescent crystal material containing heavy atoms as well as a preparation method and application thereof, and belongs to the technical field of luminescent materials. The chemical formula of the X-ray luminescent crystal material is 2XL at-AMnBr4, 2XL represents dihalogen substituted p-phenylenediamine hydrobromide, halogen atoms are one or two of Cl, Br and I, and A represents crown ether. According to the invention, heavy atoms are introduced into the organic cation module of the organic-inorganic hybrid metal halide through the multistage supramolecular self-assembly effect for the first time, the luminescence property and stability of the X-ray luminescent material are improved, and the luminescent quantum yield reaches 60% or more. The X-ray luminescent material provided by the invention is used as a scintillator of a core component, can efficiently convert X-rays into visible light signals, and provides more accurate and rapid analysis and detection for multiple fields such as safety inspection, scientific research, medical diagnosis and the like.

The invention provides a crystal form of a compound HIF-117 salt as well as a preparation method and application of the crystal form, and the crystal form is any one or more of the following crystal forms: a hydrochloride crystal form A, a sulfate crystal form B, a 1, 2-ethanedisulfonate crystal form C1, 1, 2-ethanedisulfonate crystal form C2, 1, 2-ethanedisulfonate crystal form C3 and 1, 2-ethanedisulfonate crystal form C4. The crystal form 1, 2-ethanedisulfonate crystal form C2, p-toluenesulfonate crystal form D, mesylate crystal form E1, mesylate crystal form E2, hydrobromide crystal form F1, hydrobromide crystal form F2, sodium salt crystal form G, sylvite crystal form H1, sylvite crystal form H2, calcium salt crystal form I, magnesium salt crystal form J, choline salt crystal form K, lysine salt crystal form L, ammonium salt crystal form M, meglumine salt crystal form N, betaine salt crystal form O1, betaine salt crystal form O2 and diethylamine salt crystal form P1, the invention relates to a diethylamine salt crystal form P1, a diethylamine salt crystal form P2, a diethylamine salt crystal form P3, a diethylamine salt crystal form P4, a diethylamine salt crystal form P5, a tromethamine salt crystal form Q1, a tromethamine salt crystal form Q2 and a tromethamine salt crystal form Q3. The compound has good stability, and has important value for development and production of medicines and preparations.

The invention discloses a green synthesis method of a fluorine-containing biphenyl liquid crystal material monomer, aiming at the pain points that the traditional synthesis process of the fluorine-containing biphenyl liquid crystal material monomer is serious in pollution, difficult in catalyst recovery and complex in purification. According to the method, a graphene-loaded Pd-Ni bimetallic heterogeneous catalyst is prepared firstly, then an intermediate is prepared through a water-ethylene glycol dimethyl ether system Suzuki coupling reaction, mild deprotection is achieved through a hydrobromic acid-acetic acid mixed system, recrystallization purification is conducted through an ethanol-water mixed solvent, the catalyst can be recycled, the solvent system is environmentally friendly, the process is suitable for industrial production, and the method is suitable for industrial production. The obtained monomer has the excellent performance of adapting to TN type and STN type liquid crystal display devices, and has the advantages of environmental protection, cost and practical adaptability of products.

The invention relates to an improved synthesis process of a cesium germanium bromide halogen perovskite material. The improved synthesis process comprises the following reaction steps: (1) constructing a condensation reflux device and a nitrogen pipeline; (2) weighing germanium dioxide, hydrobromic acid, concentrated hypophosphorous acid and absolute ethyl alcohol; (3) putting the three-neck flask into an oil bath pan, and connecting a condensation reflux device and a nitrogen gas path; (4) after germanium dioxide is completely dissolved, the solution in the flask is clarified; (5) injecting the cesium bromide solution into the three-neck flask in a nitrogen environment, heating, and reacting for a period of time; (6) cooling the solution to room temperature in a nitrogen environment, and collecting a yellow cesium germanium bromide crude product; and (8) refining the crude cesium germanium bromide to obtain refined cesium germanium bromide, wherein the impurity content is lower than 0.5%. According to the method, the cesium-germanium bromide solution and methylbenzene are used, so that the problem that divalent germanium ions and cesium bromide are not completely reacted is solved, and a good solution is provided for synthesizing a high-purity cesium-germanium bromide material.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of a 1, 2, 4-triazine derivative. The 1, 2, 4-triazine derivative is prepared by taking a compound I and an amine compound (a compound II and / or an acid salt thereof) as initial raw materials, taking dimethyl sulfoxide as a solvent and an oxidizing agent and carrying out one-step efficient oxidation tandem cyclization reaction in the presence of a halogen simple substance. The preparation method provided by the invention has the advantages of simple steps, high yield, avoidance of use of highly corrosive hydrobromic acid and highly toxic selenium dioxide, mild reaction conditions and low production cost, and is suitable for large-scale production. Moreover, according to the preparation method provided by the invention, no unstable intermediate is generated, byproducts are few, and the high-purity 1, 2, 4-triazine derivative can be obtained through simple post-treatment steps.

This application discloses an analytical method for N-nitrosamine vortioxetine in vortioxetine hydrobromide tablets, belonging to the field of pharmaceutical impurity analysis. The method employs high-performance liquid chromatography (HPLC), with the following chromatographic conditions: a 4.6 mm × 250 mm column packed with octadecylsilane-bonded silica gel, with a particle size of 5 μm; mobile phase A is a 90:10 water-acetonitrile mixture containing 0.025%–0.035% trifluoroacetic acid (v / v); mobile phase B is acetonitrile; gradient elution; column temperature 38–42 °C; flow rate 0.9–1.1 ml / min; injection volume 50 μl; and detection wavelength 226 nm. This analytical method effectively eliminates excipient interference and exhibits excellent detection performance (specificity, sensitivity, linearity, precision, accuracy, and robustness), accurately detecting the content of N-nitrosamine vortioxetine in vortioxetine hydrobromide tablets, meeting quality control requirements.

The utility model is suitable for the technical field of MHB raw material hydrobromic acid rectification, and provides a filtering device for MHB raw material hydrobromic acid rectification, which comprises a tank body, the top surface of the tank body is open, an annular plate is arranged above the tank body, the annular plate is lapped on the top surface of the tank body, the bottom surface of the annular plate is provided with a filter cartridge, and the bottom surface of the filter cartridge is provided with a filter screen. A baffle is arranged at the bottom of the filter cylinder, a cylinder body is arranged in the filter cylinder in a penetrating manner, the top surface of the cylinder body is open, a silica gel layer and an activated carbon adsorption layer are arranged in the cylinder body, a discharging pipe is arranged on the bottom surface of the cylinder body, and a discharging pipe is arranged on the side wall of the bottom of the tank body in a communicating manner; preferably, a PTFE filter membrane layer is arranged between the silica gel layer and the activated carbon adsorption layer. According to the scheme, the silica gel layer, the PTFE filter membrane layer, the activated carbon adsorption layer, the filter cartridge and other filtering modes are matched with one another, so that the filtering effect can be greatly improved; the silica gel layer, the PTFE filter membrane layer and the activated carbon adsorption layer can be replaced regularly, so that the continuous filtering effect is ensured.

The invention discloses a corrosion method for simultaneously corroding zns and tellurium-cadmium-mercury, and relates to the technical field of chip manufacturing, and the method comprises the following steps: providing a chip with a zinc sulfide layer and a tellurium-cadmium-mercury layer on the surface, forming a graphical photoresist mask, and exposing an area to be corroded; mixing hydrobromic acid with bromine, fully stirring, and standing for 10-20 minutes to obtain a corrosive liquid; immersing the processed chip into a corrosive liquid, and standing and corroding for 30-60 seconds; taking out the corroded chip, and immediately placing the corroded chip in flowing pure water for standing so as to terminate the corrosion reaction; the photoresist mask is removed, and graphical corrosion of the chip is completed; according to the method, high-quality one-step synchronous corrosion of the ZnS / HgCdTe double-layer structure is realized, inherent defects of a step-by-step process are fundamentally avoided, the corrosion morphology is uniform and consistent, lateral undercutting is effectively inhibited, the quality is greatly improved, a complex multi-step process is simplified into one step, the dependence on high-skill operators is reduced, the production period is shortened, and the production cost is reduced. The method is more suitable for large-scale automatic production.

The utility model relates to a sulfuric acid separation system for bromine production completion liquid, and belongs to the technical field of inorganic chemical equipment. The system comprises a foam catching chamber, an absorption tower, an MRO membrane, a sulfuric acid tank and a hydrobromic acid tank, the bottoms of the foam catching chamber and the absorption tower are connected with a high-pressure pump through a finished liquid conveying pipeline, the high-pressure pump is connected with the input end of the MRO membrane, the output end of the MRO membrane is connected with the sulfuric acid tank and the hydrobromic acid tank, and the sulfuric acid tank is connected with an acidified brine line and a sulfuric acid loading pipeline through the sulfuric acid pump. The hydrobromic acid tank is connected with a distillation system and a hydrobromic acid loading pipeline through a hydrobromic acid pump. According to the utility model, sulfuric acid and hydrobromic acid in the finished liquid are separated by using the MRO membrane, and the separated sulfuric acid and hydrobromic acid are used for production or sale, so that the pattern of a single bromine product is refreshed.

The invention discloses a preparation method of hydrobromic acid vortioxetine, and belongs to the technical field of organic synthesis. The method comprises the following steps: by taking o-aminothiophenol and Boc2O as initial raw materials, carrying out amino protection to obtain an intermediate 1; reacting the intermediate 1 with 2, 4-dimethyl bromobenzene under an alkaline condition to form a thioether bond, and acidifying to obtain an intermediate 2; carrying out high-temperature cyclization on the intermediate 2 and bis (2-bromoethyl) amine hydrobromide in mesitylene, so as to obtain a crude product of the hydrobromic acid vortioxetine; and recrystallizing the crude product with 95% ethanol to obtain a high-purity final product. The route is simple, only three-step reaction is needed, a noble metal catalyst is not needed in the whole process, and the problem of metal residues is fundamentally avoided; the selected raw materials are easy to obtain, the reaction condition is mild, the operation is simple and convenient, the process is stable, the total yield is good, the product purity is as high as 99.9%, and the method is suitable for large-scale production.

The present invention relates to polymorphs of the hydrobromide salt of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (linaprazangrate), more specifically Form A, Form B, and Form C of the HBr salt of linaprazangrate. The present invention also relates to pharmaceutical compositions containing such polymorphs and to the use of these polymorphs in the treatment or prevention of gastrointestinal inflammatory or gastric acid-related diseases, particularly erosive gastroesophageal reflux disease (eGERD).

The invention relates to guanidine-containing hydrobromide electrolyte for a high-energy-density zinc-bromine-iodine battery as well as a preparation method and application of the guanidine-containing hydrobromide electrolyte, and belongs to the technical field of aqueous zinc-bromine-iodine batteries. The guanidine hydrobromide-containing electrolyte for the high-energy-density zinc-bromine-iodine battery comprises guanidine hydrobromide, zinc salt and deionized water. According to the guanidine-containing hydrobromide electrolyte for the high-energy-density zinc-bromine-iodine battery, provided by the invention, redox of iodine valence state I-I0I < + > and redox of bromine valence state BrBr0 can be realized at the same time, and six-electron transfer of halogen compounds in the zinc-bromine-iodine battery is realized. On one hand, the energy density of the battery is increased to 3-4 times of the initial value, and on the other hand, the zinc-bromine-iodine battery containing the zinc-bromine-iodine battery has the advantages of being easy to manufacture and easy to industrially popularize.

This invention relates to the field of drug synthesis and microchemical technology, and discloses a method for synthesizing 6-bromopenicillinic acid based on continuous flow microreactors. The method includes dissolving 6-aminopenicillinic acid in ethanol and stirring until clear to obtain liquid A; preparing an aqueous solution of sodium nitrite and hydrobromic acid to obtain liquid B; mixing liquid A and liquid B in a first micromixer and then passing them into a microreactor pipeline for diazotization and bromination reactions, with inert gas purging the pipeline online to obtain a reaction effluent; extracting the reaction effluent with dichloromethane online in a second micromixer, then separating the organic phase using a membrane phase separator, and concentrating to obtain 6-bromopenicillinic acid. This invention utilizes the advantages of efficient mixing and precise temperature control in a continuous flow microreactor, combined with inert gas purging, to achieve continuous and stable preparation. It features safe operation, good batch stability, high production efficiency, and environmental friendliness, making it suitable for industrial production.

The present invention relates to a process for the industrial-scale production of 5-{2-[benzyl-(1-(4-hydroxyphenyl)-1-methylethyl)amino]-1-hydroxyethyl}benzene-1,3-diol hemifumarate, a salt consisting of two molecules of 5-{2-[benzyl-(1-(4-hydroxyphenyl)-1-methylethyl)amino]-1-hydroxyethyl}benzene-1,3-diol and one molecule of fumaric acid, and having the following formula: 5-{2-[benzyl-(1-(4-hydroxyphenyl)-1-methylethyl)amino]-1-hydroxyethyl}benzene-1,3-diol hemifumarate is a useful intermediate in the synthesis of 5-[(1RS)-2-[(1RS)-2-(4-hydroxyphenyl)-1-methylethyl]-amino-1-hydroxyethyl]benzene-1,3-diol hydrobromide, which is used in the pharmaceutical field under the is known by the common name fenoterol hydrobromide.

Novel crystalline forms of Nirogacestat dihydrobromide and preparation methods thereof, pharmaceutical compositions containing the crystalline forms, and uses of the crystalline forms for preparing γ-secretase inhibitor drugs and drugs for treating desmoid tumors.

The application is suitable for the technical field of inorganic substance preparation method, and provides a preparation method of bromine, which comprises the following steps: step one: a certain amount of sodium bromide and hydrobromic acid are added into a mother liquor pool and stirred to obtain a mother liquor; step two: a predetermined amount of stearic acid and polyvinylpyrrolidone are added; step three: preheating is carried out, and then the preheating is fed into an absorption tower; step four: the liquid at the bottom of the absorption tower flows into the upper part of a bromine evaporation tower, and is heated by steam in the bromine evaporation tower; water vapor and chlorine gas are introduced from the bottom of the bromine evaporation tower, and bromine steam enters the absorption tower; step five: the distillation acid liquid generated by the bromine evaporation tower flows into a preheater to be preheated; bromine steam flows out from the upper part of the bromine evaporation tower to obtain a bromine and water mixture; step six: the bromine and water mixture flows into a bromine water separation bottle to be separated, and bromine products are obtained, thereby, the bromine source is hydrogen bromide and sodium bromide; the stearic acid can effectively reduce the surface tension, so that the reaction is more uniform, and the system is stable.

The application belongs to the field of pharmaceutical chemistry and particularly relates to a preparation method of dextromethorphan hydrobromide. The method comprises the following steps: adding a reducing agent to a solution containing a compound of formula 3, adding an acid, performing a reduction reaction, obtaining a boron-containing intermediate state, and performing acid hydrolysis on the boron-containing intermediate state to obtain dextromethorphan. In the reduction reaction process for preparing dextromethorphan, sodium borohydride and an acid system are adopted, and compared with a sodium borohydride and zinc chloride system, the reaction is more complete, and the yield and purity of dextromethorphan are greatly improved. In the process for preparing dextromethorphan hydrobromide, butanone is used as a solvent, and compared with other solvents, butanone has the best refining effect, and related impurities can be effectively removed.

The invention discloses a production method and a production system of hydrogen bromide, and belongs to the technical field of electronic special gas preparation. A hydrobromic acid liquid raw material is conveyed to a first-stage rectifying tower, a first-stage tower substrate is conveyed to a second-stage rectifying tower, a second-stage tower substrate flows back to the first-stage rectifying tower, a first-stage tower top substance is conveyed to an adsorption column, and an adsorbed hydrogen bromide product is collected. Wherein the tower bottom temperature of the first-stage rectifying tower is 150-180 DEG C, the tower top temperature of the first-stage rectifying tower is-40--20 DEG C, the tower pressure of the first-stage rectifying tower is 250-750 kPa, the tower bottom temperature of the second-stage rectifying tower is 85-95 DEG C, the tower top temperature of the second-stage rectifying tower is 45-75 DEG C, and the tower pressure of the second-stage rectifying tower is 10-40 kPa. By adopting the multi-stage pressure swing distillation and adsorption dehydration under the parameter conditions, the high-purity hydrogen bromide product can be prepared, and the yield can be improved.