203 results about "Sulfoxide" patented technology

The invention relates to the technical field of biochemical engineering, in particular to a method for preparing chiral alpha-trifluoromethyl alcohol by using imine reductase AtRedAm, trifluoromethyl ketone is reduced into corresponding chiral trifluoromethyl alcohol at an excellent conversion rate by using the imine reductase AtRedAm, and enantioselectivity is high. The reaction depends on an NADPH (Nicotinamide Adenine Dinucleotide Phosphate) coenzyme circulation system, 10% dimethyl sulfoxide is used as a reaction cosolvent, the reaction is carried out in a 100mM (pH = 7.5) phosphate buffer solution for 16 hours, the highest molar conversion rate reaches 99%, and the highest optical purity reaches 95%.

The invention belongs to the technical field of thermoelectric materials and functional polymer materials, and particularly relates to thermoelectric hydrogel based on synergistic enhancement of zwitterions and a polar solvent as well as a method and application of the thermoelectric hydrogel. The thermoelectric hydrogel is obtained through the steps that a precursor solution is subjected to a polymerization reaction to form a gel matrix, then the gel matrix is soaked in a soaking solution, potassium ferricyanide / potassium ferrocyanide redox couple is introduced, and the thermoelectric hydrogel is obtained, and the precursor solution is prepared from acrylamide, N-isopropylacrylamide, dimethyl sulfoxide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide and N, N-dimethylformamide. The photoinitiator is prepared by mixing N, N-dimethylformamide, 1-ethyl-3-methylimidazolium tetrafluoroborate, a zwitterionic monomer [2-(methylacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide, a cross-linking agent N, N '-methylene bisacrylamide, a photoinitiator and deionized water. The thermoelectric hydrogel prepared by the invention has high mechanical strength, high ductility and high Seebeck coefficient, and has better temperature resistance.

The invention discloses a dual-band acridine formic acid anthracene methyl ester photocatalyst as well as a preparation method and application thereof, and belongs to the field of heterocyclic compounds. The invention designs and synthesizes a novel acridine formic acid anthracene methyl ester photocatalyst, which has good compatibility in two wavebands of 365 nm and 405 nm, can realize photocatalysis of disulfide compounds and aryl formyl peroxide compounds, and provides a new thought for preparation of sulfoxide compounds with asymmetric structures; the reaction conditions are mild, the reaction time is short, the photocatalyst can be recycled, the circulation loss is low, the circulation efficiency is high, the production efficiency is greatly improved, and the production period and cost are reduced; the product is free of transition metal residues and high in yield.

The invention discloses a folic acid modified active oxygen response type sodium alginate nano-carrier and application thereof, and the preparation method comprises the following steps: firstly synthesizing-Se-Se-FA: stirring dicyclohexylcarbodiimide, 4-dimethylaminopyridine, dimethyl sulfoxide / pyridine, a double-selenium fragment and folic acid at room temperature for 18-22 hours in an argon environment; and carrying out acetone precipitation, centrifugation, washing, rotary evaporation concentration and freeze-drying. The preparation method comprises the following steps: preparing an ALG-Se-FA carrier, stirring sodium alginate, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and hydroxysuccinimide in a 2-morpholinoethanesulfonic acid buffer solution, adding DMSO, dissolving a double-selenium fragment and a-Se-Se-FA fragment in DMSO and deionized water, adding the dissolved double-selenium fragment and-Se-Se-FA fragment into a system, stirring, dialyzing, and freeze-drying to obtain the product. According to the carrier, a double-selenium bond ROS response unit and folic acid targeting molecules are introduced through covalent bonds, astaxanthin can be efficiently entrapped and protected, and after the carrier is stable in gastrointestinal environment and reaches a colitis disease part, high ROS level can be responded, and intelligent drug slow release is achieved through folic acid receptor targeting.

The present invention relates to a method of preparing a heterogeneous linear carbonate, the method including performing a transesterification reaction of dimethyl carbonate (DMC) and ethanol (EtOH) in the presence of a catalyst, wherein the catalyst is one or more selected from the group consisting of lithium methoxide (LME), lithium ethoxide (LEE), sodium methoxide (SME), sodium hydroxide (NaOH), and a mixture thereof, and the catalyst is input in a state of being dissolved in a sulfoxide-based solvent.

Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.

The invention relates to a process for preparing 1,2′-benzisothiazoline-3-one according to formula (I), comprising the following steps: (a) reacting a 2-halogenbenzonitrile compound of general formula (II) with a reaction mixture, containing: (i) alkaline sulphide and / or alkaline hydrogen sulphide and (ii) an alkyl halide compound, represented by general formula (III): R1X (III) for producing an intermediate product of general formula (IV), and (b) reacting the intermediate product of general formula (V) obtained in step (a) with a halogenating agent or an oxidant and subsequent reaction of the 2-(alkylsulfoxy)benzonitrile with an acid to form 1,2-benzisothiazoline-3-one as well as a halide compound of general formula (V) R1X (V).

The invention provides a preparation method of a recombinant human blood coagulation factor VIII and a product of the recombinant human blood coagulation factor VIII. The preparation method comprises the step of culturing a mammalian cell strain for expressing the recombinant human blood coagulation factor VIII in a serum-free culture medium of a compound containing copper ions and methionine sulfoximine. By adopting the preparation method provided by the invention, the purity of the recombinant human blood coagulation factor VIII product can be further improved on the basis of keeping the high activity and high yield of the recombinant human blood coagulation factor VIII product obtained by culture.

The invention relates to the technical field of organic chemistry, in particular to a method for synthesizing a benzothiophene coupling product through a non-metal-participated anchoring-migration strategy. The method comprises the following steps: taking a benzothiophene compound or a benzothiophene sulfoxide compound as a reaction substrate, mixing the reaction substrate with an aryl nucleophilic reagent in the presence of an anhydride activator and a solvent, and carrying out nucleophilic substitution reaction to obtain benzothiophene sulfonium salt; the preparation method comprises the following steps: mixing benzothiophene sulfonium salt with an organic solvent, and carrying out metal-catalysis-free intramolecular migration reaction to form a carbon-carbon bond at the C2 site of benzothiophene, thereby obtaining the benzothiophene coupling product. The preparation conditions are mild, the operation is simple and convenient, a traditional oxidation addition-reduction elimination process is replaced by an anchoring-migration strategy, protection of a noble metal catalyst, a complex ligand, strong base or inert gas is not needed, and the problems of high cost, metal residues, harsh reaction conditions and limited substrate applicability in the prior art are fundamentally solved.

The application discloses a modified organosilicon defoaming agent and a preparation method thereof, and relates to the technical field of defoaming. The modified organosilicon defoaming agent and the preparation method thereof comprise the following components by mass ratio: 89.57 g of liquid mercaptan silicone oil, 20.30 g of triethylamine, 89.57 g of dimethyl sulfoxide, 3.45 g of a methyl-terminated allyl polyoxyethylene ether, 13.80 g of a methyl-terminated allyl polyoxypropylene ether, 0.34 g of azobisdimethyl isobutyronitrile, 32.25 g of butyl acetate, 19.29 g of 2-bromoisobutyrate methyl ester, a magnesium sulfate and sodium chloride aqueous solution, a coupling agent and a thickening agent. The modified organosilicon defoaming agent has good defoaming performance and bubble inhibiting performance, has strong compatibility with different emulsions, and has defoaming performance and bubble inhibiting performance equivalent to polyether defoaming agents in a water-based resin system.

This invention belongs to the field of pharmaceutical technology, specifically providing a new method for synthesizing crude dotenoradine. This invention uses 2-aminobenzylthiol as the starting material, and obtains crude dotenoradine through cyclization reaction, first oxidation reaction, acylation reaction, and second oxidation reaction. It mainly utilizes the relatively weak oxidizing property of hydrogen peroxide, which makes it difficult to directly oxidize sulfide (1) to sulfone (2') in a high yield. Instead, relatively expensive m-chloroperoxybenzoic acid is still needed to complete the oxidation. This invention controls the oxidation of sulfide by controlling the amount of hydrogen peroxide and the composite catalyst and catalytic aid, so that most of the oxidation products remain in the sulfoxide structure (2) and are difficult to completely convert to the sulfone structure. After another oxidation reaction, the amount of m-chloroperoxybenzoic acid can be reduced relatively much, thus reducing the synthesis cost of crude dotenoradine.

This invention discloses a halogen-free flame-retardant polypropylene material and its preparation method, comprising 60-80 parts of polypropylene (PP), 4-8 parts of toughening agent, 15-25 parts of halogen-free flame retardant, 1-1.5 parts of antioxidant, 2-3 parts of light stabilizer, and 5-10 parts of modified graphene oxide flame retardant synergist. The modified graphene oxide flame retardant synergist is prepared by "nucleophilic substitution acyl chloride-nucleophilic substitution amidation-electrostatic interaction" using graphene oxide (GO), anhydrous sulfoxide, an amine compound H2N-R-NH2 containing at least two terminal primary amino groups, and molybdate. The -R- group is a divalent organic group used to connect the amide bond to the terminal primary amino group. The modified graphene oxide flame retardant synergist includes at least one amide bond -CONH-R-N- connected to the terminal primary amino group. The halogen-free flame-retardant polypropylene material provided by this invention exhibits excellent flame retardant properties while also improving its impact resistance and anti-dripping effect, and is safe and environmentally friendly.

The present application relates to a preparation method of cyprosulfamide, and the cyprosulfamide is prepared by using a one-pot method, and the method specifically comprises the following steps: adding an organic base, a reaction solvent, 2-chloro-3-(2,2,2-trifluoroethoxy)methyl-4-methylsulfonylbenzoic acid and a Curtius condensing agent into a reaction container, heating and refluxing for 3-5 h to generate an active ester intermediate; after the reaction solution containing the active ester intermediate is cooled, 1,3-cyclohexanedione and acetone cyanohydrin are added to perform a condensation rearrangement reaction, and cyprosulfamide is generated. The one-pot synthesis process is adopted, the use of dimethyl sulfoxide is avoided, compared with a traditional process, the method is green, environmentally friendly, has low safety risks, has high yield and good purity, and is more suitable for industrialized production.

The invention belongs to the field of agricultural acaricides. In particular to a biphenyl thioether (sulfoxide) compound and application thereof. The structure is shown as a general formula I, wherein each substituent group in the formula is defined in the specification. The compound as shown in the general formula I has excellent acaricidal activity and can be used for preventing and treating various pest mites.

This invention discloses a method for preparing 4-(trifluoromethylsulfinyl)pyrazole compounds, comprising: dissolving terminal alkyne in n-hexane under nitrogen atmosphere, adding anhydrous zinc chloride, and reacting trifluoromethylsulfinyl chloride to obtain α-trifluoromethylalkynyl sulfoxide; adding benzoyl chloride dropwise to a CH2Cl2 solution of phenylhydrazine and triethylamine under nitrogen atmosphere to obtain acylhydrazine; adding carbon tetrachloride to a suspension of acylhydrazine and triphenylphosphine in acetonitrile to obtain hydrazone chloride; and reacting α-trifluoromethylalkynyl sulfoxide, hydrazone chloride, potassium carbonate, and anhydrous ethanol at room temperature to obtain 4-(trifluoromethylsulfinyl)pyrazole compounds. This invention uses inexpensive and readily available raw materials, the entire reaction route is mild and simple to operate, does not require stringent reaction conditions, and most of the reaction process is carried out at room temperature. The product yield is high, and the prepared trifluoromethylalkynyl sulfoxide pyrazole structure has multiple derivatization sites, showing good application prospects.

To provide heterocyclic derivatives that are pesticidally active, in particular insecticidally active, as well as methods for exterminating and controlling insects, mites, nematodes, or mollusks.SOLUTION: The present invention provides a compound of formula (I) (where A is CH or N, and Q is a nitrogen-containing heterocyclic ring).SELECTED DRAWING: None

A composition comprising an oily medium system and an active ingredient, and a method of increasing the bioavailable rate of an active ingredient, where the method comprises incorporating the active ingredient into an oily medium system, and where the oily medium system contains a vegetable oil and / or a component of a vegetable oil, the liquid does not contain the following substances: a phosphate buffer solution, polyethylene glycol, dimethyl sulfoxide, ethanol, polypropylene glycol, polysorbate, ethyl acetate, 12-hydroxystearic acid hydroxyethyl ester and tocopherol polyethylene glycol succinate; the active ingredient is selected from the group consisting of compounds of formula (I) wherein T1 is a C6 cyclic hydrocarbon and R1 is a C1-C8 aliphatic hydrocarbon group, pharmaceutically acceptable salts thereof, and combinations thereof.

The present application provides a polyboron-nitrogen derivative, a deep blue light-emitting device and a light-emitting apparatus, the polyboron-nitrogen derivative having a structure of formula (I), wherein R 1 , R 2 each independently represent a C1-C36 alkyl or aryl substituent; R 3 , R 4 , R 5 , R 6 , R 7 , R 8 each independently represent hydrogen or a C1-C36 substituent; the C1-C36 substituent is substituted in a single bond or in a ring; A1, A2 each independently represent oxygen, sulfur, selenium, a sulfoxide group, a sulfone group, a carbon substituent of a C1-C36 alkyl or aryl substituent, a nitrogen substituent of a C1-C36 alkyl or aryl substituent, or are not present. The polyboron-nitrogen derivative used in the present application has the characteristics of high light-emitting efficiency, high color purity, and suitability for solution process devices.

A vanadium catalyst composition and a preparation method and application thereof. The vanadium catalyst composition is composed of a vanadium complex and an electron donor, the ligand of the vanadium complex is one of fatty alcohols, amines and phosphate esters, the electron donor is a sulfoxide compound, and the structural formula is R—S(═O)—R′, R is selected from one of C1-C3 alkyl, aryl, C1-C3 alkyl substituted aryl; R′ is selected from one of C1-C3 alky, aromatic alkyl. An electronic donor with oxidation property is adopted, an aqueous phase extraction method is combined, and a vanadium catalyst composition with a reactivation function is synthesized by a one-step method.

The invention relates to a residual stress detection method of a polycarbonate component and a detection reagent thereof. The raw materials of the detection reagent comprise absolute ethyl alcohol, ethyl acetate, isopropanol, cyclohexanone and dimethyl sulfoxide. Ester bonds in a PC molecular chain can be permeated by sulfoxide groups of DMSO, so that hydrogen bonds are damaged and chain segments are loosened. Ethyl acetate and isopropanol can permeate into gaps of PC molecular chains, so that the volume expansion of the material is caused to induce microcracks. The carbonyl group of cyclohexanone can form strong interaction force with the carbonic ester group in the PC molecular chain; the polymer is small in molecular size and can rapidly permeate into gaps of PC molecular chains to damage hydrogen bonds and Van der Waals force among PC molecules, so that the molecular chains are dissociated. Therefore, the detection reagent can enable the high residual stress part of the polycarbonate component to rapidly generate obvious cracks.

The application discloses a synthesis method of monofluoro olefin compound and belongs to the technical field of organic synthesis. 3 )‑F bond and C(sp 2 )‑F bond are broken to obtain a trisubstituted (E) monofluoro olefin compound 3; when the olefin substrate is gem-di-fluoro olefin 4, a di / trisubstituted (E) monofluoro olefin compound 5 is also obtained at a high yield and excellent stereoselectivity. The synthesis method has the advantages of cheap catalyst, simple and easily-obtained raw materials and good substrate applicability, and the synthesized product is a very valuable fluorinated component, and a new method is provided for modification of fluorine-containing molecules.

The present invention relates to a methionine sulfoxide reductase B1 inhibitor and an anticancer composition comprising same. More specifically, the present invention relates to 4-[3-(4-ethylphenyl)-5-(4-hydroxyphenyl) -4,5-dihydro -1 H-pyrazol-1-yl]benzene-1-sulfonamide or 6-chloro-10-(4-ethylphenyl)-4-hydroxypyrimido[4,5-b]quinolin-2(10H)-one, which is a MsrB1 inhibitor, and an anticancer composition comprising same. The MsrB1 inhibitor of the present invention has been confirmed to inhibit differentiation into tumor-friendly M2 macrophages and to suppress tumor growth. In addition, the MsrB1 inhibitor of the present invention was found to exhibit anticancer effects through immune regulation within the tumor microenvironment, and thus can be usefully applied as a composition for cancer treatment.

The invention provides a polyimide material, a polyimide film and a preparation method and application thereof, and belongs to the technical field of polyimide film preparation. The polyimide material is prepared from a diamine monomer and a dianhydride monomer through a condensation reaction, wherein the sum of mole numbers of ether bonds on a main chain of the polyimide material and carbonyl, methylene, sulfoxide, sulfonyl, hexafluoroisopropylidene and isopropylidene in a non-cyclic structure does not exceed 50% of the total mole number of the diamine monomer and the dianhydride monomer. Particularly, a meta-substituted 5-7-membered cyclic diamine structure is introduced into a diamine monomer, a drafting process is optimized, and a drafting preparation process is improved, so that the polyimide film product has a thermal expansion coefficient of-10 to 25 ppm / K; the shrinkage rate after being treated at 400 DEG C for 30 minutes is less than or equal to And the glass transition temperature is not less than 400 DEG C.

The invention relates to a synthesis method of a difluoroalkyl sulfone compound and / or a difluoroalkyl sulfoxide compound. The synthesis method comprises the following steps: taking a compound 1 and a compound 2 as raw materials, adding alkali, reacting in a solvent, oxidizing and decarboxylating; the structure of the compound 1 is shown as a formula (I-1) or a formula (I-2); the structures of the difluoroalkyl sulfone compound and the difluoroalkyl sulfoxide compound are respectively shown as a formula (II) and a formula (III); ; wherein M is selected from Na, K, NH4 or a hydrogen atom; r1 is selected from C1-C8 straight chain or straight chain alkyl; r2 is selected from a C1-C8 straight chain or branched chain alkylene group; r is selected from C1-C8 linear chain or branched chain alkyl; the structural general formula of the compound 2 is ClRf; and Rf is selected from a linear chain or branched chain alkyl group containing a difluoromethyl group of C1-C15. The one-pot method is adopted, the alkyl sulfone and the alkyl sulfoxide are prepared by using the same synthetic route, the synthetic reaction is simple, the substrate limitation is less, the cost is low, the reaction is fast, the yield is high, and the industrial production can be realized.

The invention provides a battery, a positive pole piece, a preparation method of the positive pole piece and a power utilization device. The battery comprises a positive pole piece, the positive pole piece comprises a positive pole film layer, and the positive pole film layer comprises a positive pole active layer and a positive pole interface layer arranged on the surface of the positive pole active layer; wherein the positive electrode interface layer comprises a polar polymer and a polar solvent, and the polar solvent comprises one or more of a sulfone solvent, a sulfoxide solvent, a nitrile solvent, fluorocarbonate, a fluoroether solvent, fluorosulfate, fluorocarboxylate and fluorosilane. Therefore, the cycle performance and the storage performance of the battery can be improved.

The invention discloses a novel camptothecin compound or a stereoisomer or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the camptothecin compound or the stereoisomer or the pharmaceutically acceptable salt, and application of the camptothecin compound or the stereoisomer or the pharmaceutically acceptable salt as an antitumor drug. According to the structure, R1, R2 and R3 are independently selected from hydrogen, deuterium, halogen, hydroxyl, cyano, sulfydryl, sulfuryl, sulfoxide, nitro, substituted or unsubstituted amido, carboxyl, acylamino, deuterated alkyl, C1-6 alkyl, C1-6 alkoxy, C1-6 halogenated alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C3-6 heterocyclic radical, aryl or heteroaryl; or R1 and R2 as well as R2 and R3 are respectively connected with adjacent carbon atoms to form 5-7-membered cycloalkyl or heterocycloalkyl; the 5-to 7-membered cycloalkyl or heterocyclic cycloalkyl is optionally substituted by one or more halogens or deuterium atoms, alkyl and alkoxy. The compound has a good anti-tumor effect.

The application provides a modified biomass carbon material-based lithium battery negative electrode material and a preparation method thereof, and the preparation method comprises the following steps: (1) preparing modified nano silicon; (2) under a nitrogen atmosphere, ultrasonic dispersion is carried out on the modified nano silicon prepared in the step (1) and dichloro sulfoxide, N,N-dimethylformamide is added, the temperature is increased to 70-80 DEG C, a modified conductive material is added, reaction is carried out at 70-80 DEG C for 20-25 h, and a mixed solution is obtained; (3) the mixed solution in the step (2) is subjected to spray drying, the inlet temperature of the spray drying is 220-250 DEG C, the outlet temperature is 120-150 DEG C, and the modified biomass carbon material-based lithium battery negative electrode material is obtained; the lithium battery negative electrode material prepared by the application has high conductivity, the charging and discharging efficiency is improved, and the service life of the lithium ion battery at different temperatures is increased.

The invention discloses a method for catalytic synthesis of sulfoximine guanidine compounds by cobalt dichloride, which realizes efficient preparation of the sulfoximine guanidine compounds by taking cobalt dichloride as a catalyst and through free radical coupling reaction of sulfoximine compounds, isonitrile compounds and sulfonyl azide compounds. The method can effectively protect high-valence thioguanidyl, has the advantages of mild reaction conditions, high synthesis efficiency and strong substrate universality, and has extremely high practical application value.