690 results about "Sulfoxide" patented technology

The invention provides a nano imbibition displacement agent suitable for shale oil reservoirs and a preparation method thereof, and the nano imbibition displacement agent comprises the following raw materials in parts by weight: 30-50 parts of sulfonated graphene oxide, 10-15 parts of silane coupling agent modified nano silicon dioxide, 10-20 parts of water-soluble cellulose ether, 10-20 parts of fatty alcohol-polyoxyethylene ether, 5-8 parts of lower alcohol and 50-80 parts of water. Graphene oxide reacts with concentrated nitric acid to prepare acidified graphene oxide, then the acidified graphene oxide reacts with thionyl chloride to prepare acylating-chlorinated graphene oxide, and the acylating-chlorinated graphene oxide reacts with a sodium aminobenzene sulfonate derivative to prepare the graphene oxide. Electrostatic repulsive force is generated among graphene oxide particles through surface sulfonation treatment, the dispersing capacity among the particles is improved, agglomeration and flocculation among the particles are avoided, and the recovery efficiency is improved; sulfonated graphene oxide cooperates with a large-molecular-weight water-soluble cellulose ether surfactant, so that the temperature resistance and the salt resistance of the nano imbibition displacement agent can be remarkably improved.

The invention discloses a preparation method for selectively oxidizing thioether into sulfoxide through photo-initiation, and belongs to the field of synthesis of medical compounds. The preparation method comprises the following steps that in the air atmosphere, a thioether compound is dissolved in an acetonitrile-water mixed solvent, inorganic metal salt catalysts such as ferric chloride and copper sulfate are added, the mixture reacts for 8-48 h at the temperature of 0-45 DEG C under illumination with the wavelength of 295-405 nm, selective oxidation is carried out, and the sulfoxide product is obtained, and the molar ratio of thioether to the catalysts is 5: 1. The method overcomes the problems of excessive oxidation risk, complicated operation, environmental pollution and the like caused by dependence of a noble metal catalyst and use of a strong oxidant in the existing thioether oxidation method, has the advantages of high catalytic efficiency, high yield and excellent selectivity, can greatly reduce the production cost, is suitable for later industrial synthesis and amplification, and has wide application prospects. The method has the advantages of no expensive metal catalyst or oxidant, simple preparation process, high efficiency, environmental protection, safety and cost saving.

The invention relates to the technical field of biochemical engineering, in particular to a method for preparing chiral alpha-trifluoromethyl alcohol by using imine reductase AtRedAm, trifluoromethyl ketone is reduced into corresponding chiral trifluoromethyl alcohol at an excellent conversion rate by using the imine reductase AtRedAm, and enantioselectivity is high. The reaction depends on an NADPH (Nicotinamide Adenine Dinucleotide Phosphate) coenzyme circulation system, 10% dimethyl sulfoxide is used as a reaction cosolvent, the reaction is carried out in a 100mM (pH = 7.5) phosphate buffer solution for 16 hours, the highest molar conversion rate reaches 99%, and the highest optical purity reaches 95%.

This application relates to sulfoxide and sulfone compounds of Formula (X) and other compounds that may be useful to activate glucokinase as part of a treatment for various diseases including diabetes. Further encompassed are pharmaceutical compositions comprising a compound according to the invention.

The disclosure provides for cryopreservation formulations, cryopreservation media and method of cryopreserving mammalian cells or tissues. The cryopreservation formulations and media contain a combination of cryoprotective agents selected from the group consisting of; (a) glycerol and trehalose; (b) glycerol, trehalose, and ascorbic acid; (c) glycerol, trehalose, and taurine: and (d) glycerol, trehalose, ascorbic acid, and taurine. In certain embodiments, the cryopreservation formulations and media are free of dimethyl sulfoxide.

The invention belongs to the technical field of soil organic matter improvers, and discloses a soil organic matter improver based on a compound microbial agent and a preparation method thereof, and the soil organic matter improver comprises the following components: a compound enzyme, a modified chitosan microsphere complex, a modified polyelectrolyte, an inhibitor L-methionine sulfoximine, a substrate, an auxiliary factor and the compound microbial agent. A compound enzyme system is used as a core, soil ammonium ions are circularly and efficiently assimilated through glutamine synthetase / glutamate synthetase, and the soil ammonium ions are converted into organic nitrogen; and energy guarantee is provided by virtue of polyphosphate kinase. The modified chitosan microsphere complex is used for protecting and slowly releasing enzyme and a substrate, and controlled release of the inhibitor L-methionine sulfoximine is realized through the modified polyelectrolyte, so that carbon-nitrogen balance of soil is regulated and controlled. The system has a synergistic effect with a compound microbial agent, the problem of soil organic matter reduction caused by excessive nitrogen application is effectively solved, meanwhile, the crop root biomass is remarkably increased, and the soil organic matter content is increased.

The invention provides a lithium battery diaphragm and a preparation method thereof, and the preparation method comprises the following steps: carrying out a reaction on melamine and terephthalaldehyde in dimethyl sulfoxide to obtain SNW-1COF; the preparation method comprises the following steps: enabling SNW-1COF to react with allyl-1, 3-sultone in acetonitrile, so as to obtain allyl SCOF; the polyarylether benzimidazole, the 2-sulfydryl-5-fluorobenzimidazole, triethylamine and allyl SCOF are subjected to a reaction in a third solvent, and a membrane casting solution is obtained; and applying the membrane casting solution to a base material, and removing the solvent in the membrane casting solution to obtain the lithium battery diaphragm. According to the invention, the OPBI matrix and the propenyl SCOF react to form a covalent cross-linked network, so that the mechanical properties of the diaphragm in the aspects of thermal shrinkage rate, tensile strength, puncture strength and the like and the electrical properties in the aspects of wettability and ionic conductivity are improved.

The invention relates to preparation and application of a substituted alkyl sulfide (sulfoxide) arylamine derivative. Specifically, the invention relates to a compound as shown in a formula (I), or an isotope labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, and an application of the compound in preparation of an acaricide for preventing and controlling pest mites, wherein the compound is used as a substituted alkyl sulfide (sulfoxide)-based arylamine derivative. The compound can achieve a better pest mite control effect at a lower dosage.

The invention relates to a preparation method of an oxygen vacancy-rich bismuth molybdate / bismuth vanadate composite photo-anode and a product and application thereof, and belongs to the technical field of photoelectrocatalysis. The invention discloses a preparation method of an oxygen vacancy-rich bismuth molybdate / bismuth vanadate (Bi2Mo2O9 / BiVO4) composite photo-anode, which mainly comprises the following steps: immersing a fluorine ion-doped tin dioxide (FTO) conductive glass substrate into a Bi < 3 + > ion solution and an I <-> ion solution to form a bismuth oxyiodide (BiOI) film, dropwise adding a dimethyl sulfoxide solution of vanadyl acetylacetonate (VO (acac) 2), and putting into a muffle furnace to prepare the BiVO4 photo-anode. And then vertically immersing into a Bi < 3 + > ion solution and a Mo < 6 + > ion solution, and carrying out annealing treatment in an argon atmosphere to prepare the Bi2Mo2O9 / BiVO4 composite photoanode rich in oxygen vacancies. The Bi2Mo2O9 / BiVO4 material rich in oxygen vacancies is a metal oxide composite photo-anode, the photoelectrocatalysis efficiency can be improved, and hydrogen peroxide (H2O2) can be continuously generated in natural seawater through photoelectrocatalytic oxidation of water for a long time.

The invention belongs to the technical field of thermoelectric materials and functional polymer materials, and particularly relates to thermoelectric hydrogel based on synergistic enhancement of zwitterions and a polar solvent as well as a method and application of the thermoelectric hydrogel. The thermoelectric hydrogel is obtained through the steps that a precursor solution is subjected to a polymerization reaction to form a gel matrix, then the gel matrix is soaked in a soaking solution, potassium ferricyanide / potassium ferrocyanide redox couple is introduced, and the thermoelectric hydrogel is obtained, and the precursor solution is prepared from acrylamide, N-isopropylacrylamide, dimethyl sulfoxide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide and N, N-dimethylformamide. The photoinitiator is prepared by mixing N, N-dimethylformamide, 1-ethyl-3-methylimidazolium tetrafluoroborate, a zwitterionic monomer [2-(methylacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide, a cross-linking agent N, N '-methylene bisacrylamide, a photoinitiator and deionized water. The thermoelectric hydrogel prepared by the invention has high mechanical strength, high ductility and high Seebeck coefficient, and has better temperature resistance.

The invention discloses desulfurized rubber modified asphalt and a preparation method thereof, and the desulfurized rubber modified asphalt comprises the following components in parts by mass: 100 parts of petroleum asphalt, 25-35 parts of desulfurized rubber powder, 0.2-2 parts of oxime sulfonate modifier, and 0.5-3 parts of modified artificial zeolite. Wherein the desulfurized rubber powder is prepared from the following raw materials: waste rubber powder, calcium nitrate, aniline, 2, 5-benzothiazole dithiol, p-methylphenyl magnesium bromide, diphenyl sulfoxide and trimethylchlorosilane in a mass ratio of (80-100): (10-20): (20-30): (5-10): (5-6): 1: (3-4); the invention further discloses a specific preparation method of the desulfurized rubber powder. The asphalt provided by the invention has the advantages of simple components, improved performances, low mixing temperature and more convenient use.

The invention provides a preparation method of an imrecoxib intermediate as shown in a formula I. The preparation method is characterized by comprising the following steps: reacting p-tolueneacetic acid with 4-methylsulfonyl chloroacetophenone in the presence of halogenated salt and an organic solvent to generate the imrecoxib intermediate I: # imgabs0 #. The method is low in cost, green and environment-friendly, simple in process operation, less in side reaction, simple and convenient in post-treatment and high in purity of the obtained finished product, and sulfoxide impurities are not easy to form; the preparation method greatly alkalifies the technological process, is mild in reaction condition, controllable in reaction process quality and high in yield, has the cost advantage and is suitable for industrial mass production.

The invention belongs to the technical field of organic synthesis, and particularly relates to a pyroxasulfone preparation method which specifically comprises the following steps: dissolving 3-(5-difluoromethoxy-1-methyl-3-trifluoromethyl-1H-pyrazol-4-ylmethylthio)-5, 5-dimethyl-2-isoxazoline serving as a raw material with a solvent, then adding a boron compound, finally dropwise adding hydrogen peroxide, and reacting at room temperature to obtain the pyroxasulfone. Reacting for several hours to obtain pyroxasulfone; the adopted boron compound is cheap and easy to obtain, so that the use of a transition metal catalyst is avoided, and the raw material cost is reduced; organic acid reagents with heavy odor are not used, waste water and solid waste are less, and the method has great advantages in the aspect of environmental protection; the method is simple to operate, free of complex treatment steps and suitable for industrial production, and when the boron compound is selected from sodium metaborate, sodium perborate or a mixture of borax and sodium metaborate, the yield and purity of the process are higher, and sulfoxide impurities are fewer.

The invention discloses a preparation method of a triazine desulfurizer. The method comprises the following steps: 1, adding primary amine into a three-neck round-bottom flask, and stirring; 2, slowly dropwise adding a formaldehyde aqueous solution in a stirring state, carrying out a constant-temperature reaction, and carrying out reduced pressure distillation purification to obtain a triazine desulfurizer main body; and 3, uniformly stirring and mixing the triazine desulfurizer main body, peracetic acid, polyethylene glycol and ethylenediamine to obtain the triazine desulfurizer. The triazine desulfurizing agent is prepared by compounding the triazine desulfurizing agent main body with the peracetic acid, the polyethylene glycol and the ethylenediamine, so that hydrogen sulfide in a sulfur-containing system is effectively removed, organic sulfur benzothiophene substances which are difficult to remove are converted into sulfoxide and sulfone which are easy to remove, and the compatibility of the triazine desulfurizing agent and the sulfur-containing system is improved; therefore, the desulfurization rate is greatly improved, the sulfur content in a sulfur-containing system is remarkably reduced, and the method is suitable for the field of desulfurization.

The invention provides a hydrated eutectic electrolyte as well as a preparation method and application thereof. The electrolyte comprises water-soluble zinc salt, deionized water and a deep eutectic solution, the deep eutectic solution is formed by mixing zinc perchlorate and a polar deep eutectic solvent and performing deep eutectic crystallization. The electrolyte has the characteristics of low water activity, low freezing point and efficient induction of uniform deposition of zinc, can be compatible with an iodine-loaded positive electrode and can inhibit dissolution of iodine, and the characteristics are beneficial to inhibition of hydrogen evolution reaction, polyiodine shuttling and other side reactions in the battery circulation process, promote uniform deposition of zinc, protect the integrity of an iodine electrode, and improve the electrochemical performance of the battery. The stable operation of the zinc-iodine battery is ensured; the electrolyte is a zinc sulfate solution containing a ZnClO4 / dimethyl sulfoxide deep eutectic solvent, the solution is combined with free water to form a eutectic structure, the eutectic structure participates in construction of a Zn < 2 + > ion solvation shell, extra intramolecular hydrogen bonds are introduced for the electrolyte, meanwhile, hydrogen bonds among water molecules are weakened, so that the internal energy of the electrolyte is enhanced, the freezing point is reduced, and the flowability is improved.

The invention discloses a dual-band acridine formic acid anthracene methyl ester photocatalyst as well as a preparation method and application thereof, and belongs to the field of heterocyclic compounds. The invention designs and synthesizes a novel acridine formic acid anthracene methyl ester photocatalyst, which has good compatibility in two wavebands of 365 nm and 405 nm, can realize photocatalysis of disulfide compounds and aryl formyl peroxide compounds, and provides a new thought for preparation of sulfoxide compounds with asymmetric structures; the reaction conditions are mild, the reaction time is short, the photocatalyst can be recycled, the circulation loss is low, the circulation efficiency is high, the production efficiency is greatly improved, and the production period and cost are reduced; the product is free of transition metal residues and high in yield.

The invention provides a preparation method of (S)-oxetane-2-methylamine. The preparation method of (S)-oxetane-2-methylamine comprises the following steps: (1) carrying out ring closing reaction on a compound A under an alkaline condition to obtain a compound B; (2) reacting the compound B with dibenzylamine to obtain a compound C; (3) reacting the compound C with a reducing agent to obtain a compound D; (4) reacting the compound D with paratoluensulfonyl chloride to obtain a compound E; (5) reacting the compound E with alkali to obtain a compound F; and (6) carrying out a reaction on the compound F and palladium on carbon to obtain the (S)-oxetane-2-methylamine. According to the preparation method provided by the invention, ring expansion reaction using trimethylsulfoxide iodide in the prior art is avoided, the problem that residual sulfur elements cause poisoning of a palladium-carbon catalyst is solved, meanwhile, sodium azide is also avoided, and the preparation method is safe and reliable in process, high in chiral purity and yield and suitable for industrial large-scale production.

The invention relates to the technical field of organic sulfide preparation, in particular to a method for synthesizing and refining dimethyl sulfide (DMS) and dimethyl sulfoxide (DMSO) embedded into a methanol plant, which mainly utilizes high-purity oxygen of an air separation unit of the methanol plant, a high-concentration hydrogen sulfide product of low-temperature methanol washing and part of top gas-phase refined methanol of a pressurizing tower of a methanol rectification device. The production cost of the product is reduced, the added value of the product is improved, and the hydrogen sulfide product of a methanol plant is effectively utilized.

The invention discloses a polysaccharide-based supramolecular gel polymer electrolyte based on a high-concentration electrolyte system as well as a preparation method and application of the polysaccharide-based supramolecular gel polymer electrolyte, and the preparation method comprises the following steps: dissolving hydroxypropyl chitosan (HPCS) in dimethyl sulfoxide (DMSO) to prepare an HPCS-DMSO solution; the preparation method comprises the following steps: dissolving lithium bis (trifluoromethanesulfonic acid) imide (LiTFSI) into DMSO (Dimethylsulfoxide) to prepare a high-concentration LiTFSI-DMSO solution; and mixing the two solutions to obtain the polysaccharide-based supramolecular gel polymer electrolyte, wherein the prepared gel can be used for preparing an energy storage device. According to the present invention, the groups having interaction with the anions and the solvent molecules are pertinently introduced into the polymer, and the double-bridging structure formed by the anion-Li < + >-solvent molecules is utilized to slow down the diffusion of the anions and achieve the Li < + > rapid transition mode, such that the Li < + > migration number in the gel network and the electrode interface stability are improved, and the wide application prospect is provided.

The invention belongs to the technical field of preparation processes of chemical products, and particularly relates to a method for preparing chloroacetyl chloride through a reaction tower and a rectification tower and an integrated tower preparation device. The invention relates to a method for preparing chloroacetyl chloride by a reaction tower and a rectification tower, which comprises the following steps of: metering liquid chloroacetic acid, preheating the liquid chloroacetic acid by a preheater, metering raw material thionyl chloride, gasifying the raw material thionyl chloride in a gasifier, feeding the gasified raw material thionyl chloride into the bottom of a reaction tower, and reacting the raw material thionyl chloride with the chloroacetic acid from the upper part of the reaction tower in the reaction tower, the tower bottom of the reaction tower is heated by a reboiler; and 2, cooling reaction steam from the reaction tower through a tower top condenser, enabling reflux liquid to enter the tower top of the reaction tower for total reflux, carrying out mass transfer and heat transfer on the steam in the reaction tower, extracting from a side line pipeline, and cooling through a side extraction condenser to obtain the finished product chloroacetyl chloride. According to the method for preparing chloroacetyl chloride through the reaction tower and the rectification tower, energy is saved, consumption is reduced, the product quality is stable, and the purity is high; the invention further provides an integrated tower preparation device which is low in investment and high in efficiency.

The invention relates to a preparation method of high-yield and high-purity polyphenylene sulfide, and belongs to the field of oxidative polymerization. The technical problem to be solved by the invention is to provide a production method of polyphenylene sulfide with mild reaction conditions, high yield and high purity. According to the method, diphenyl disulfide is taken as a raw material, thionyl chloride is taken as a solvent, oxygen is taken as an oxidizing agent, a vanadium-based Lewis acid complex is taken as a catalyst, and the main technological process comprises the steps of feeding, synergistic action of the catalyst and the oxygen, polymerization, filtration, washing, drying and oxidative polymerization at normal temperature and normal pressure to obtain the high-yield and high-purity polyphenylene sulfide. The method is simple in process flow and mild in condition, does not need to introduce other polymerization additives, avoids the influence of metal sodium salt and other by-products generated by many preparation methods on the toughness of the product, and has the yield of almost 100% and high product purity.

The invention relates to the field of chemical synthesis, and specifically discloses a method for synthesizing ascorbic acid tetraisopalmitate. The method is a one-step synthesis, comprising: mixing an alkaline substance, a condensing agent and vitamin C with 2-hexyldecanoic acid in an organic solvent, and performing an esterification reaction to obtain ascorbic acid tetraisopalmitate. The synthesis method avoids the generation of by-products such as ascorbic acid palmitate (CAS No.: 137-66-6) and ascorbic acid dipalmitate (CAS No.: 28474-90-0), and avoids the use of a strong corrosive agent thionyl chloride, thereby extending the service life of equipment and reducing the pressure of daily maintenance and inspection of equipment. The reaction conditions are mild, the reaction process is controllable, the product is easy to separate and purify, the yield is high, the purity is high, and the method is suitable for industrial-scale production.

The invention belongs to the field of industrial application of microbial fermentation, and relates to a microorganism for efficiently producing ergothioneine as well as a preparation method and application of the microorganism. Specifically, the method comprises the following steps: firstly, artificially creating a promoter with a group response property by utilizing saturation mutation and screening of a fluorescence microscope; then, the promoter is used for mediating host bacterium heterologous histidine methyltransferase, sulfoxide synthase and PLP dependent C-S lyase to improve the yield of ergothioneine; on the basis, an endogenous promoter HisJ of host bacteria is replaced, and endogenous cysteine lyase yhaM is knocked out, so that the yield of the ergothioneine is increased again. According to combination of the above strategies, a heuristic and commercialized production thought is provided for efficient synthesis of ergothioneine, and a foundation is laid for reduction of the synthesis cost of ergothioneine.

The invention discloses a folic acid modified active oxygen response type sodium alginate nano-carrier and application thereof, and the preparation method comprises the following steps: firstly synthesizing-Se-Se-FA: stirring dicyclohexylcarbodiimide, 4-dimethylaminopyridine, dimethyl sulfoxide / pyridine, a double-selenium fragment and folic acid at room temperature for 18-22 hours in an argon environment; and carrying out acetone precipitation, centrifugation, washing, rotary evaporation concentration and freeze-drying. The preparation method comprises the following steps: preparing an ALG-Se-FA carrier, stirring sodium alginate, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and hydroxysuccinimide in a 2-morpholinoethanesulfonic acid buffer solution, adding DMSO, dissolving a double-selenium fragment and a-Se-Se-FA fragment in DMSO and deionized water, adding the dissolved double-selenium fragment and-Se-Se-FA fragment into a system, stirring, dialyzing, and freeze-drying to obtain the product. According to the carrier, a double-selenium bond ROS response unit and folic acid targeting molecules are introduced through covalent bonds, astaxanthin can be efficiently entrapped and protected, and after the carrier is stable in gastrointestinal environment and reaches a colitis disease part, high ROS level can be responded, and intelligent drug slow release is achieved through folic acid receptor targeting.

The invention is suitable for the technical field of fine chemical engineering, and provides a synthesis method of sulpiride impurity 2-hydroxy-5-sulfanilamide benzamide, which comprises the following specific steps: Step 1, taking salicylic acid as a raw material, taking DMF as a catalyst, and carrying out acylation reaction with thionyl chloride to obtain acylation liquid, and entering the next process; 2, ammoniating the acylation liquid with ammonia water at a low temperature to obtain salicylic acid formamide, and drying to obtain an intermediate 1; 3, TMS-Cl is used for protecting phenolic hydroxyl groups, then chlorosulfonic acid is dropwise added, a chlorosulfonation reaction is carried out, and an intermediate 2 solution is obtained after the reaction is completed; and Step 4, dropwise adding the solution of the intermediate 2 into stronger ammonia water for reaction, carrying out suction filtration, and recrystallizing with ethanol to obtain the sulpiride impurity 2-hydroxy-5-sulfanilamide benzamide. The route synthesis is simple, and the quality can reach 95% or above; in addition, the method has the advantages of cheap and easily available raw materials, mild reaction conditions, low energy consumption, simple process structure, easy operation and the like.

The invention discloses a preparation method of (S)-3-aminobutyronitrile hydrochloride compounds, which comprises the following steps: S1, chlorination reaction: adding thionyl chloride and a catalyst into a reaction solvent, controlling a certain temperature, dropwise adding a compound 1, reacting at a certain temperature after dropwise adding, and dropwise adding into water for quenching to obtain an aqueous solution of a compound 2; s2, cyaniding reaction: adding the compound 2 into a reaction solvent, adding a 30% sodium cyanide solution, controlling a certain temperature, reacting for a certain time, extracting and layering after the reaction is finished, washing an organic phase with a sodium chloride solution, and concentrating to obtain a compound 5; and S3, salt forming reaction: dropwise adding a solution of an HCl (gas) organic solvent into the organic solvent of the compound 5, controlling a certain temperature, reacting for a certain time, and after the reaction is finished, cooling, filtering and drying to obtain a target compound 6. The (S)-3-aminobutyronitrile hydrochloride is obtained with the mole yield of 68.5%, the cost is low, and the cost competitiveness is very high.

Lipid composition comprising: (i) one or more cationic lipids, preferably cationically ionizable lipids, (ii) one or more phospholipids, and (iii) one or more statistical copolymers comprising repeating units of the following formula (I-a) and repeating units of formula (II-a) wherein R1 represents a hydrogen atom or a group selected from a C1-3 alkyl group, a cyclopropyl group, and a C3 alkenyl group; R2 represents a group selected from a saturated C4-40 hydrocarbyl group; an unsaturated C4-40 hydrocarbyl group having one or more carbon-carbon double and / or triple bonds; a saturated C4-40 heterohydrocarbyl group containing 1 to 5 divalent groups selected from ether, thioether, sulfone, sulfoxide, keto, ester, amide, carbamate and carbonate groups, and / or 1 to 5 fluorine atoms as substituents; and an unsaturated C4-40 heterohydrocarbyl group having one or more carbon-carbon double and / or triple bonds, and containing 1 to 5 divalent groups selected from ether, keto, ester, and carbonate groups and / or 1 to 5 fluorine atoms as substituents; and x and y independently represent 0 or 1.

The invention discloses a preparation method of a molecularly imprinted magnetic covalent organic framework nano-material, which comprises the following steps: adding Fe3O4 nano-particles, ethyl carbamate, substituted triazine aromatic amine, 2, 4, 6-trihydroxy trimesic aldehyde and 1, 3, 5-triazine-2, 4, 6-tricarboxaldehyde into dimethyl sulfoxide, mixing, then adding anhydrous acetic acid, stirring and reacting at room temperature, filtering, washing, and drying to obtain the molecularly imprinted magnetic covalent organic framework nano-material. After the reaction is finished, carrying out magnetic separation to obtain Fe3O4 (at) COFs; washing the Fe3O4 (at) COFs with an ethanol solution, washing the Fe3O4 (at) COFs with water, and drying the washed Fe3O4 (at) COFs to obtain a molecularly imprinted magnetic covalent organic framework nano material MIPs-Fe3O4 (at) COFs; compared with the prior art, after the prepared MIPs-Fe3O4-coated COFs are repeatedly used for 10 times, the removal efficiency of the prepared MIPs-Fe3O4-coated COFs on ethyl carbamate still can reach 97% or above, and the removal efficiency of the prepared MIPs-Fe3O4-coated COFs on ethyl carbamate is improved.

The invention relates to the field of organic chemistry and medicinal chemistry, in particular to an indeno-aza compound I as well as a preparation method and medical application thereof. The method comprises the following steps: adding an amine compound into an indeno-oxa-heptacyclic compound serving as a raw material under solvent-free and additive-free conditions, directly adding stoichiometric thionyl chloride and a solvent acetonitrile into an intermediate product obtained after the reaction without separation and pretreatment to continue the reaction, adding alkali again without separation and pretreatment after the reaction is completed, and separating and purifying to obtain the product. And controlling the reaction temperature to finally prepare the indeno-aza compound. The invention reports a compound with a novel structure, and develops a one-pot continuous operation synthesis method of the compound. The synthesis operation of the method conforms to the concept of green chemistry, and the obvious advantages of chemical synthesis means are embodied. Meanwhile, the compound has a certain inhibition effect on human esophageal cancer cells and human bladder cancer cells.

The invention discloses an ergothioneine-producing recombinant engineering bacterium as well as a construction method and application thereof, and belongs to the technical field of gene recombination fermentation. The method comprises the following steps: by taking escherichia coli as a starting bacterium, carrying out recombinant expression on a histidine trimethyl inner salt cysteine sulfoxide synthetase egt1 gene, an L-histidine methyltransferase egtD gene, a histidine trimethyl inner salt cysteine sulfoxide lyase egt2 gene, a methionine adenosine transferase metK gene, an adenylate kinase adK gene and an adenine phosphoribose transferase apt gene; on this basis, supply of precursor substances including histidine, cysteine and methionine is further improved through metabolic transformation, the yield of the finally obtained recombinant engineering bacterium for producing ergothioneine reaches 2.54 g / L after 48 h of shake-flask culture, the yield of a 5L fermentation tank reaches 18 g / L after further enlarged culture, the yield of ergothioneine is guaranteed while energy consumption and cost are reduced, and the method is suitable for industrial production. The method is suitable for practical popularization.