525 results about "Sulfoxide" patented technology

The invention discloses a preparation method for selectively oxidizing thioether into sulfoxide through photo-initiation, and belongs to the field of synthesis of medical compounds. The preparation method comprises the following steps that in the air atmosphere, a thioether compound is dissolved in an acetonitrile-water mixed solvent, inorganic metal salt catalysts such as ferric chloride and copper sulfate are added, the mixture reacts for 8-48 h at the temperature of 0-45 DEG C under illumination with the wavelength of 295-405 nm, selective oxidation is carried out, and the sulfoxide product is obtained, and the molar ratio of thioether to the catalysts is 5: 1. The method overcomes the problems of excessive oxidation risk, complicated operation, environmental pollution and the like caused by dependence of a noble metal catalyst and use of a strong oxidant in the existing thioether oxidation method, has the advantages of high catalytic efficiency, high yield and excellent selectivity, can greatly reduce the production cost, is suitable for later industrial synthesis and amplification, and has wide application prospects. The method has the advantages of no expensive metal catalyst or oxidant, simple preparation process, high efficiency, environmental protection, safety and cost saving.

The invention relates to the technical field of biochemical engineering, in particular to a method for preparing chiral alpha-trifluoromethyl alcohol by using imine reductase AtRedAm, trifluoromethyl ketone is reduced into corresponding chiral trifluoromethyl alcohol at an excellent conversion rate by using the imine reductase AtRedAm, and enantioselectivity is high. The reaction depends on an NADPH (Nicotinamide Adenine Dinucleotide Phosphate) coenzyme circulation system, 10% dimethyl sulfoxide is used as a reaction cosolvent, the reaction is carried out in a 100mM (pH = 7.5) phosphate buffer solution for 16 hours, the highest molar conversion rate reaches 99%, and the highest optical purity reaches 95%.

This application relates to sulfoxide and sulfone compounds of Formula (X) and other compounds that may be useful to activate glucokinase as part of a treatment for various diseases including diabetes. Further encompassed are pharmaceutical compositions comprising a compound according to the invention.

The invention belongs to the technical field of soil organic matter improvers, and discloses a soil organic matter improver based on a compound microbial agent and a preparation method thereof, and the soil organic matter improver comprises the following components: a compound enzyme, a modified chitosan microsphere complex, a modified polyelectrolyte, an inhibitor L-methionine sulfoximine, a substrate, an auxiliary factor and the compound microbial agent. A compound enzyme system is used as a core, soil ammonium ions are circularly and efficiently assimilated through glutamine synthetase / glutamate synthetase, and the soil ammonium ions are converted into organic nitrogen; and energy guarantee is provided by virtue of polyphosphate kinase. The modified chitosan microsphere complex is used for protecting and slowly releasing enzyme and a substrate, and controlled release of the inhibitor L-methionine sulfoximine is realized through the modified polyelectrolyte, so that carbon-nitrogen balance of soil is regulated and controlled. The system has a synergistic effect with a compound microbial agent, the problem of soil organic matter reduction caused by excessive nitrogen application is effectively solved, meanwhile, the crop root biomass is remarkably increased, and the soil organic matter content is increased.

The invention provides a lithium battery diaphragm and a preparation method thereof, and the preparation method comprises the following steps: carrying out a reaction on melamine and terephthalaldehyde in dimethyl sulfoxide to obtain SNW-1COF; the preparation method comprises the following steps: enabling SNW-1COF to react with allyl-1, 3-sultone in acetonitrile, so as to obtain allyl SCOF; the polyarylether benzimidazole, the 2-sulfydryl-5-fluorobenzimidazole, triethylamine and allyl SCOF are subjected to a reaction in a third solvent, and a membrane casting solution is obtained; and applying the membrane casting solution to a base material, and removing the solvent in the membrane casting solution to obtain the lithium battery diaphragm. According to the invention, the OPBI matrix and the propenyl SCOF react to form a covalent cross-linked network, so that the mechanical properties of the diaphragm in the aspects of thermal shrinkage rate, tensile strength, puncture strength and the like and the electrical properties in the aspects of wettability and ionic conductivity are improved.

The invention relates to preparation and application of a substituted alkyl sulfide (sulfoxide) arylamine derivative. Specifically, the invention relates to a compound as shown in a formula (I), or an isotope labeled compound thereof, or an optical isomer, a geometric isomer, a tautomer or an isomer mixture thereof, or a pharmaceutically acceptable salt thereof, and an application of the compound in preparation of an acaricide for preventing and controlling pest mites, wherein the compound is used as a substituted alkyl sulfide (sulfoxide)-based arylamine derivative. The compound can achieve a better pest mite control effect at a lower dosage.

The invention relates to a preparation method of an oxygen vacancy-rich bismuth molybdate / bismuth vanadate composite photo-anode and a product and application thereof, and belongs to the technical field of photoelectrocatalysis. The invention discloses a preparation method of an oxygen vacancy-rich bismuth molybdate / bismuth vanadate (Bi2Mo2O9 / BiVO4) composite photo-anode, which mainly comprises the following steps: immersing a fluorine ion-doped tin dioxide (FTO) conductive glass substrate into a Bi < 3 + > ion solution and an I <-> ion solution to form a bismuth oxyiodide (BiOI) film, dropwise adding a dimethyl sulfoxide solution of vanadyl acetylacetonate (VO (acac) 2), and putting into a muffle furnace to prepare the BiVO4 photo-anode. And then vertically immersing into a Bi < 3 + > ion solution and a Mo < 6 + > ion solution, and carrying out annealing treatment in an argon atmosphere to prepare the Bi2Mo2O9 / BiVO4 composite photoanode rich in oxygen vacancies. The Bi2Mo2O9 / BiVO4 material rich in oxygen vacancies is a metal oxide composite photo-anode, the photoelectrocatalysis efficiency can be improved, and hydrogen peroxide (H2O2) can be continuously generated in natural seawater through photoelectrocatalytic oxidation of water for a long time.

The invention belongs to the technical field of thermoelectric materials and functional polymer materials, and particularly relates to thermoelectric hydrogel based on synergistic enhancement of zwitterions and a polar solvent as well as a method and application of the thermoelectric hydrogel. The thermoelectric hydrogel is obtained through the steps that a precursor solution is subjected to a polymerization reaction to form a gel matrix, then the gel matrix is soaked in a soaking solution, potassium ferricyanide / potassium ferrocyanide redox couple is introduced, and the thermoelectric hydrogel is obtained, and the precursor solution is prepared from acrylamide, N-isopropylacrylamide, dimethyl sulfoxide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide, N, N-dimethylformamide and N, N-dimethylformamide. The photoinitiator is prepared by mixing N, N-dimethylformamide, 1-ethyl-3-methylimidazolium tetrafluoroborate, a zwitterionic monomer [2-(methylacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide, a cross-linking agent N, N '-methylene bisacrylamide, a photoinitiator and deionized water. The thermoelectric hydrogel prepared by the invention has high mechanical strength, high ductility and high Seebeck coefficient, and has better temperature resistance.

The invention provides a preparation method of an imrecoxib intermediate as shown in a formula I. The preparation method is characterized by comprising the following steps: reacting p-tolueneacetic acid with 4-methylsulfonyl chloroacetophenone in the presence of halogenated salt and an organic solvent to generate the imrecoxib intermediate I: # imgabs0 #. The method is low in cost, green and environment-friendly, simple in process operation, less in side reaction, simple and convenient in post-treatment and high in purity of the obtained finished product, and sulfoxide impurities are not easy to form; the preparation method greatly alkalifies the technological process, is mild in reaction condition, controllable in reaction process quality and high in yield, has the cost advantage and is suitable for industrial mass production.

The invention belongs to the technical field of organic synthesis, and particularly relates to a pyroxasulfone preparation method which specifically comprises the following steps: dissolving 3-(5-difluoromethoxy-1-methyl-3-trifluoromethyl-1H-pyrazol-4-ylmethylthio)-5, 5-dimethyl-2-isoxazoline serving as a raw material with a solvent, then adding a boron compound, finally dropwise adding hydrogen peroxide, and reacting at room temperature to obtain the pyroxasulfone. Reacting for several hours to obtain pyroxasulfone; the adopted boron compound is cheap and easy to obtain, so that the use of a transition metal catalyst is avoided, and the raw material cost is reduced; organic acid reagents with heavy odor are not used, waste water and solid waste are less, and the method has great advantages in the aspect of environmental protection; the method is simple to operate, free of complex treatment steps and suitable for industrial production, and when the boron compound is selected from sodium metaborate, sodium perborate or a mixture of borax and sodium metaborate, the yield and purity of the process are higher, and sulfoxide impurities are fewer.

The invention provides a hydrated eutectic electrolyte as well as a preparation method and application thereof. The electrolyte comprises water-soluble zinc salt, deionized water and a deep eutectic solution, the deep eutectic solution is formed by mixing zinc perchlorate and a polar deep eutectic solvent and performing deep eutectic crystallization. The electrolyte has the characteristics of low water activity, low freezing point and efficient induction of uniform deposition of zinc, can be compatible with an iodine-loaded positive electrode and can inhibit dissolution of iodine, and the characteristics are beneficial to inhibition of hydrogen evolution reaction, polyiodine shuttling and other side reactions in the battery circulation process, promote uniform deposition of zinc, protect the integrity of an iodine electrode, and improve the electrochemical performance of the battery. The stable operation of the zinc-iodine battery is ensured; the electrolyte is a zinc sulfate solution containing a ZnClO4 / dimethyl sulfoxide deep eutectic solvent, the solution is combined with free water to form a eutectic structure, the eutectic structure participates in construction of a Zn < 2 + > ion solvation shell, extra intramolecular hydrogen bonds are introduced for the electrolyte, meanwhile, hydrogen bonds among water molecules are weakened, so that the internal energy of the electrolyte is enhanced, the freezing point is reduced, and the flowability is improved.

The invention discloses a dual-band acridine formic acid anthracene methyl ester photocatalyst as well as a preparation method and application thereof, and belongs to the field of heterocyclic compounds. The invention designs and synthesizes a novel acridine formic acid anthracene methyl ester photocatalyst, which has good compatibility in two wavebands of 365 nm and 405 nm, can realize photocatalysis of disulfide compounds and aryl formyl peroxide compounds, and provides a new thought for preparation of sulfoxide compounds with asymmetric structures; the reaction conditions are mild, the reaction time is short, the photocatalyst can be recycled, the circulation loss is low, the circulation efficiency is high, the production efficiency is greatly improved, and the production period and cost are reduced; the product is free of transition metal residues and high in yield.

The invention provides a preparation method of (S)-oxetane-2-methylamine. The preparation method of (S)-oxetane-2-methylamine comprises the following steps: (1) carrying out ring closing reaction on a compound A under an alkaline condition to obtain a compound B; (2) reacting the compound B with dibenzylamine to obtain a compound C; (3) reacting the compound C with a reducing agent to obtain a compound D; (4) reacting the compound D with paratoluensulfonyl chloride to obtain a compound E; (5) reacting the compound E with alkali to obtain a compound F; and (6) carrying out a reaction on the compound F and palladium on carbon to obtain the (S)-oxetane-2-methylamine. According to the preparation method provided by the invention, ring expansion reaction using trimethylsulfoxide iodide in the prior art is avoided, the problem that residual sulfur elements cause poisoning of a palladium-carbon catalyst is solved, meanwhile, sodium azide is also avoided, and the preparation method is safe and reliable in process, high in chiral purity and yield and suitable for industrial large-scale production.

The invention relates to the technical field of organic sulfide preparation, in particular to a method for synthesizing and refining dimethyl sulfide (DMS) and dimethyl sulfoxide (DMSO) embedded into a methanol plant, which mainly utilizes high-purity oxygen of an air separation unit of the methanol plant, a high-concentration hydrogen sulfide product of low-temperature methanol washing and part of top gas-phase refined methanol of a pressurizing tower of a methanol rectification device. The production cost of the product is reduced, the added value of the product is improved, and the hydrogen sulfide product of a methanol plant is effectively utilized.

The invention belongs to the field of industrial application of microbial fermentation, and relates to a microorganism for efficiently producing ergothioneine as well as a preparation method and application of the microorganism. Specifically, the method comprises the following steps: firstly, artificially creating a promoter with a group response property by utilizing saturation mutation and screening of a fluorescence microscope; then, the promoter is used for mediating host bacterium heterologous histidine methyltransferase, sulfoxide synthase and PLP dependent C-S lyase to improve the yield of ergothioneine; on the basis, an endogenous promoter HisJ of host bacteria is replaced, and endogenous cysteine lyase yhaM is knocked out, so that the yield of the ergothioneine is increased again. According to combination of the above strategies, a heuristic and commercialized production thought is provided for efficient synthesis of ergothioneine, and a foundation is laid for reduction of the synthesis cost of ergothioneine.

The invention discloses a folic acid modified active oxygen response type sodium alginate nano-carrier and application thereof, and the preparation method comprises the following steps: firstly synthesizing-Se-Se-FA: stirring dicyclohexylcarbodiimide, 4-dimethylaminopyridine, dimethyl sulfoxide / pyridine, a double-selenium fragment and folic acid at room temperature for 18-22 hours in an argon environment; and carrying out acetone precipitation, centrifugation, washing, rotary evaporation concentration and freeze-drying. The preparation method comprises the following steps: preparing an ALG-Se-FA carrier, stirring sodium alginate, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and hydroxysuccinimide in a 2-morpholinoethanesulfonic acid buffer solution, adding DMSO, dissolving a double-selenium fragment and a-Se-Se-FA fragment in DMSO and deionized water, adding the dissolved double-selenium fragment and-Se-Se-FA fragment into a system, stirring, dialyzing, and freeze-drying to obtain the product. According to the carrier, a double-selenium bond ROS response unit and folic acid targeting molecules are introduced through covalent bonds, astaxanthin can be efficiently entrapped and protected, and after the carrier is stable in gastrointestinal environment and reaches a colitis disease part, high ROS level can be responded, and intelligent drug slow release is achieved through folic acid receptor targeting.

The invention is suitable for the technical field of fine chemical engineering, and provides a synthesis method of sulpiride impurity 2-hydroxy-5-sulfanilamide benzamide, which comprises the following specific steps: Step 1, taking salicylic acid as a raw material, taking DMF as a catalyst, and carrying out acylation reaction with thionyl chloride to obtain acylation liquid, and entering the next process; 2, ammoniating the acylation liquid with ammonia water at a low temperature to obtain salicylic acid formamide, and drying to obtain an intermediate 1; 3, TMS-Cl is used for protecting phenolic hydroxyl groups, then chlorosulfonic acid is dropwise added, a chlorosulfonation reaction is carried out, and an intermediate 2 solution is obtained after the reaction is completed; and Step 4, dropwise adding the solution of the intermediate 2 into stronger ammonia water for reaction, carrying out suction filtration, and recrystallizing with ethanol to obtain the sulpiride impurity 2-hydroxy-5-sulfanilamide benzamide. The route synthesis is simple, and the quality can reach 95% or above; in addition, the method has the advantages of cheap and easily available raw materials, mild reaction conditions, low energy consumption, simple process structure, easy operation and the like.

Lipid composition comprising: (i) one or more cationic lipids, preferably cationically ionizable lipids, (ii) one or more phospholipids, and (iii) one or more statistical copolymers comprising repeating units of the following formula (I-a) and repeating units of formula (II-a) wherein R1 represents a hydrogen atom or a group selected from a C1-3 alkyl group, a cyclopropyl group, and a C3 alkenyl group; R2 represents a group selected from a saturated C4-40 hydrocarbyl group; an unsaturated C4-40 hydrocarbyl group having one or more carbon-carbon double and / or triple bonds; a saturated C4-40 heterohydrocarbyl group containing 1 to 5 divalent groups selected from ether, thioether, sulfone, sulfoxide, keto, ester, amide, carbamate and carbonate groups, and / or 1 to 5 fluorine atoms as substituents; and an unsaturated C4-40 heterohydrocarbyl group having one or more carbon-carbon double and / or triple bonds, and containing 1 to 5 divalent groups selected from ether, keto, ester, and carbonate groups and / or 1 to 5 fluorine atoms as substituents; and x and y independently represent 0 or 1.

The invention discloses an ergothioneine-producing recombinant engineering bacterium as well as a construction method and application thereof, and belongs to the technical field of gene recombination fermentation. The method comprises the following steps: by taking escherichia coli as a starting bacterium, carrying out recombinant expression on a histidine trimethyl inner salt cysteine sulfoxide synthetase egt1 gene, an L-histidine methyltransferase egtD gene, a histidine trimethyl inner salt cysteine sulfoxide lyase egt2 gene, a methionine adenosine transferase metK gene, an adenylate kinase adK gene and an adenine phosphoribose transferase apt gene; on this basis, supply of precursor substances including histidine, cysteine and methionine is further improved through metabolic transformation, the yield of the finally obtained recombinant engineering bacterium for producing ergothioneine reaches 2.54 g / L after 48 h of shake-flask culture, the yield of a 5L fermentation tank reaches 18 g / L after further enlarged culture, the yield of ergothioneine is guaranteed while energy consumption and cost are reduced, and the method is suitable for industrial production. The method is suitable for practical popularization.

The invention disclosed herein relates to metal-catalyst free, green enantioselective synthesis of sulfoxide compounds of Formula-I. Particularly, the present invention relates to in situ process to obtain enantioselective sulfoxide compounds of Formula-I with high yield and purity and specific optical rotation. Further, the enantioselective sulfoxide compounds of Formula-I are useful in the treatment of neurological, neuropsychiatric, metabolic and neurodevelopmental disorder.

The present invention addresses the problem of providing a method for producing a flaked graphite dispersion having high dispersibility of flaked graphite. This method for producing a flaked graphite dispersion comprises: a first step in which a material to be treated, which contains one selected from the group consisting of graphite and a graphite compound, and a first organic solvent other than an amide-based solvent, a ketone-based solvent, or a sulfoxide-based solvent, is subjected to a wet jet mill treatment to obtain flaked graphite; and a second step in which the product obtained in step 1 is mixed with at least one specific solvent selected from the group consisting of an amide-based solvent, a ketone-based solvent, and a sulfoxide-based solvent to obtain a flaked graphite dispersion.

The invention belongs to the field of agricultural acaricides. In particular to a phenyl sulfide (sulfoxide) compound and application thereof. The structure is shown as a general formula I, wherein the definition of each substituent group in the formula # imgabs0 is shown in the specification. The compound as shown in the general formula I has excellent acaricidal activity and can be used for preventing and treating various pest mites.

The present invention relates to a method of preparing a heterogeneous linear carbonate, the method including performing a transesterification reaction of dimethyl carbonate (DMC) and ethanol (EtOH) in the presence of a catalyst, wherein the catalyst is one or more selected from the group consisting of lithium methoxide (LME), lithium ethoxide (LEE), sodium methoxide (SME), sodium hydroxide (NaOH), and a mixture thereof, and the catalyst is input in a state of being dissolved in a sulfoxide-based solvent.

The invention relates to a crystal form of a sulfoximine compound as well as a preparation method and application of the crystal form. Specifically, the invention discloses a crystal form of a compound as shown in formula (I) and a preparation method and application thereof, and the crystal form has excellent stability and can be widely applied to preparation of drugs for preventing and / or treating diseases related to increase of activity and expression quantity of FGFR2 (Fibroblast Growth Factor Receptor 2). The preferable crystal form of the # imgabs0 is a hydrochloride crystal form I of a compound shown in a formula I, and an X-ray powder diffraction pattern of the hydrochloride crystal form I has a 2 theta angle selected from the following groups: 6.68 + / -0.2 degrees, 13.34 + / -0.2 degrees and 21.42 + / -0.2 degrees.

The invention discloses a method for synthesizing a sulfur-containing compound by using an amino sulfur trifluoride compound, which comprises the following two steps: S1, by taking the amino sulfur trifluoride compound and a compound A as reactants, stirring and reacting for 8-15 minutes or 10-15 hours at normal temperature in an organic solvent under an alkaline condition; the compound A is any one of an amide compound or a sulfanilamide compound, or water; and S2, adding a nucleophilic reagent into the solution after the reaction in the step S1, stirring at normal temperature to react for 8-15 minutes or 5-8 hours, and then purifying through a rapid chromatography to obtain a final product, namely, all-heteroatom substituted thioimine or all-heteroatom substituted sulfoxide, the nucleophilic reagent is an alcohol or an amine. According to the method disclosed by the invention, the amido sulfur trifluoride compound is used for synthesizing the asymmetric full heteroatom substituted thioimine and sulfoxide compound for the first time, the reaction steps are simple, the reaction conditions are mild, and expensive reagents are not needed.

Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.

The invention relates to a ZnAl-LDH-based material as well as a preparation method and application thereof in sludge treatment. The ZnAl-LDH-based material is prepared from a divalent metal salt solution and a trivalent metal salt solution through a coprecipitation method, divalent metal comprises Zn and Cu, and trivalent metal is Al; the molar weight ratio of the divalent metal to the trivalent metal is (1-3): 1, and the ratio of the molar weight of Cu to the total molar weight of the divalent metal is (0-0.5): 1. The ZnAl-LDH-based material is used for promoting the organic sulfide in the sludge to be converted into sulfoxide sulfur and sulfone sulfur. Compared with the prior art, a series of ZnAl-LDH-based materials with proper specific surface areas and pore volume structures are prepared, and low-valence organic sulfides in municipal sludge can be promoted to be directionally converted into sulfoxide sulfur and sulfone sulfur; the method has a wide application prospect in the field of improving the high-added-value utilization of organic sulfide-containing wastes such as municipal sludge.

The present invention provides a thiadiazole compound containing a hindered phenol group, a preparation method thereof and its use in the field of lubricating oil additives. The preparation method of the thiadiazole compound containing a hindered phenol group comprises the following steps: mixing a carboxylic acid compound containing a hindered phenol group with thionyl chloride, removing impurities under reduced pressure to obtain an acyl chloride compound containing hindered phenol; stirring and mixing 2-mercapto-5-amino-1,3,4-thiadiazole with a halogenated hydrocarbon compound, filtering, washing and drying to obtain a 2-mercapto-5-amino-1,3,4-thiadiazole derivative; adding a hindered phenol acyl chloride compound, 2-mercapto-5-amino-1,3,4-thiadiazole derivative and an alkaline additive to an organic solvent, washing, drying and purifying to obtain a thiadiazole compound containing a hindered phenol group. The thiadiazole compound containing a hindered phenol group is an antioxidant, extreme pressure and anti-wear additive, which can be applied to synthetic ester lubricants and has a good antioxidant, extreme pressure and anti-wear effect.

The invention discloses a benzothiazole-tetraphenyl ethylene derivative as well as a preparation method and anti-counterfeiting application thereof, 4-(1, 2, 2-triphenyl vinyl) acetophenone and o-aminothiophenol are reacted in dimethyl sulfoxide by taking I2 as a catalyst, and after the reaction is finished, separation and purification are performed to obtain a compound molecule 1-1. And 2, carrying out heating reaction on the obtained compound 1-1 and malononitrile under the action of alkali and a solvent, and separating and purifying to obtain a compound 1-2. The compound disclosed by the invention is low in preparation cost, simple and convenient to operate and simple in method, the compound shows fluorescence characteristics and can be applied to the fields of printing and dyeing, printing ink, cosmetics and the like, and meanwhile, the synthesis method can be used for synthesis in the fields of fine organic chemical engineering such as luminescent materials and trace detection technologies.

The application provides a catalyst for synthesizing polyimide, and a structural formula of the catalyst is shown as formula (I): wherein, Ar 1 , Ar 2 are independently selected from substituted or unsubstituted aryl or substituted or unsubstituted heterocyclic aryl, R1 is oxygen, sulfur, sulfone group, sulfoxide group, carbonyl group, secondary amine group, alkylene group, alkenylene group, alkinylene group, alicyclic group, heterocyclic aryl group, fused ring aryl group or single bond. The catalyst has high reactivity, and a small amount of the catalyst is used in the synthesis of polyimide, so that the film forming property of the polyimide is not affected. The application further provides a preparation method and application of the catalyst for synthesizing polyimide.