1698 results about "Chlorobenzene" patented technology

The invention relates to the technical field of organic synthesis, and discloses a preparation method of bromo-pyrrole nitrile. The method comprises the following steps: (1) mixing p-chlorophenylglycine, acetonitrile, trifluoroacetic acid and a catalyst, then dropwise adding acyl chloride and carrying out acylation reaction, and after the reaction is completed, purging with an inert gas; (2) under the inert gas, mixing the mixture obtained in the step (1) with inorganic salt, then dropwise adding 2-chloroacrylonitrile, carrying out cyclization reaction, and separating a liquid phase from the obtained mixture; and (3) under the inert gas, mixing the liquid phase obtained in the step (2), hydrobromic acid and hydrogen peroxide, carrying out a bromination reaction, then extracting with acetonitrile to obtain an acetonitrile layer, then removing the acetonitrile, and then carrying out cooling crystallization to obtain the bromo-pyrrolenitrile. According to the technical scheme, the reaction yield is high, different solvents do not need to be frequently replaced, and the solvents can be recycled.

The invention belongs to the technical field of organic pollution treatment, and relates to a biochar-LDH-nZVI-GO composite material for organic pollution remediation and a preparation method and application thereof.The preparation method comprises the steps that graphene oxide is ultrasonically dispersed in deionized water, magnesium salt and aluminum salt are added to form uniform suspension liquid, then the uniform suspension liquid is mixed with biochar suspension liquid, and the biochar-nZVI-GO composite material is obtained; carrying out pH (Potential of Hydrogen) regulation and a hydrothermal crystallization reaction, so as to prepare a biochar-Mg / Al-LDH-GO compound; and dispersing the compound in an organic solvent, sequentially adding FeSO4. 7H2O and a NaBH4 solution in an inert atmosphere to carry out a reduction reaction, and finally washing and drying to obtain the biochar-LDH-nZVI-GO composite material. The material shows high-efficiency removal capacity on various organic pollutants such as trichloroethylene, chlorobenzene and polychlorinated biphenyl, is suitable for high-efficiency green remediation of organic pollutants in soil and water, and has good popularization and application prospects.

The invention discloses a thiazolinone acrylic acid silane ester self-polishing antifouling resin and a preparation method and application of the thiazolinone acrylic acid silane ester self-polishing antifouling resin. The preparation method of the thiazolinone acrylic acid silane ester self-polishing antifouling resin mainly comprises the following steps: in a nitrogen environment, adding an initiator, the preparation method comprises the following steps: carrying out random free radical polymerization reaction on thiazolinone methacrylate, methyl methacrylate, ethyl acrylate, triisopropyl silicon-based methacrylate and phenyl dimethyl silicon-based methacrylate by taking azodiisobutyronitrile and benzoyl peroxide as initiators to synthesize the photoinitiator. Wherein the thiazolinone methacrylate monomer is prepared by grafting double bonds on 5-chloro-2-benzothiazolinone and methacryloyl chloride through a substitution reaction, then grafting hydroxyl on the 5-chloro-2-benzothiazolinone and mercaptoethanol through a mercapto-alkene click reaction and finally carrying out a substitution reaction on the 5-chloro-2-benzothiazolinone and methacryloyl chloride. According to the invention, the coating still has good surface self-renewal capability even in a static environment so as to inhibit the adhesion of large fouling organisms.

The invention belongs to the technical field of medicine detection, and particularly relates to a high-sensitivity liquid chromatography method for detecting mutagenic impurities in atomoxetine hydrochloride key starting material 3-chlorobenzene propanol, the method adopts an HPLC (High Performance Liquid Chromatography) analysis method, a chromatographic column adopts octadecylsilane chemically bonded silica as a filler, and the composition of a mobile phase A is a buffer solution; the mobile phase B is methanol or acetonitrile; carrying out gradient elution on the mobile phase; the flow velocity is 0.4 to 0.8 ml / min; the detection wavelength is 230 to 250 nm; by adopting an HPLC analysis method, the content of mutagenic impurities in the key starting material 3-chlorobenzene propanol of atomoxetine hydrochloride can be effectively separated and measured, and the method is high in sensitivity, strong in specificity and good in accuracy and repeatability, and has extremely important significance on quality control of the key starting material 3-chlorobenzene propanol of atomoxetine hydrochloride.

The invention discloses a method for simultaneously detecting residual quantity of 19 plant growth regulators in traditional Chinese medicinal materials, and belongs to the technical field of traditional Chinese medicinal material detection. The 19 plant growth regulators in the detected traditional Chinese medicinal materials are gibberellins, 4-chlorophenoxyacetic acid, 6-benzyladenine, paclobutrazol, 3-indolebutyric acid, thidiazuron, 2, 4-dihydroxyacetophenone and 2, 4-dihydroxyacetophenone respectively. The pesticide is prepared from the following raw materials: sodium 4-dichlorphenoxyacetate, forchlorfenuron, 3-indoleacetic acid, 4-fluorophenoxyacetic acid, isopentenyl adenine, imazalil, N-N '-diphenylurea, mepiquat chloride, diethyl aminoethyl hexanoate, 1-naphthylacetic acid amine, brassin, abscisic acid and 3-indolepropionic acid. According to the method, the QUECHERS traditional Chinese medicinal material sample on-machine pretreatment technology is applied, the ultra-high performance liquid chromatography-tandem mass spectrometry is established to measure the residual quantity of the 19 plant growth regulators in the medicinal materials, and the detection method is simple, clear, few in operation steps, extremely easy to operate, good in linear relation, good in sensitivity and high in accuracy.

The invention discloses a preparation method of a polydopamine modified biochar loaded Fe-Cu sodium alginate microsphere, which comprises the following steps: preparing biochar, modifying the biochar by using polydopamine, then loading the polydopamine modified biochar by using Fe-Cu, and finally obtaining the polydopamine modified biochar loaded Fe-Cu sodium alginate microsphere. According to the preparation method, the sodium alginate microspheres with different particle sizes can be prepared, the prepared sodium alginate microspheres have the function of adsorbing ammonia nitrogen, nitrate nitrogen, chlorobenzene, phosphorus, chromium ions and lead ions, the sodium alginate microspheres are used as the inner core to prepare anaerobic ammonia oxidation granular sludge, large density and good morphological support are provided for sludge particles, the problem of sludge bulking is avoided, and the anaerobic ammonia oxidation granular sludge can be prepared by using the sodium alginate microspheres as the inner core. The sewage treatment agent has the advantages that the settling performance is improved, the adsorption capacity on organic matters, ammonia nitrogen and heavy metals is enhanced, the sewage treatment effect is improved, and meanwhile, the sewage treatment agent is a biodegradable material and does not cause secondary pollution in the use process.

The invention discloses quick-dry water-based ink and a preparation method thereof, and relates to the technical field of ink. The preparation method comprises the following steps: firstly, enabling 4, 6-bis (allyloxy)-n-butyl-1, 3, 5-thiazine-2-amine and vinyl sulfonamide to participate in a polymerization reaction of acrylic acid and butyl acrylate, and preparing 4, 6-bis (allyloxy)-n-butyl-1, 3, 5-thiazine-2-amine and vinyl sulfonamide through a two-step emulsion polymerization method; the core-shell structure modified polyester emulsion with 2, 5-thiazine-2-amine and vinyl sulfonamide as soft shells and acrylic acid and butyl acrylate as hard cores improves the wear resistance and durability of the ink. Then allyl polyether reacts with 2-(p-chlorphenyl) ethylene oxide, so that the drying time is shortened, and the wear resistance of the ink is improved; then through addition reaction of reactants, bis (2-ethoxyl) dimethyl ammonium chloride and hydrogen-containing silicone oil, the epoxy-amino-polyether combined modified silicone oil flatting agent is formed, the flatting agent has hydrophilicity and hydrophobicity, the drying speed is increased, and the wear-resistant effect is improved.

The invention discloses a method for preparing a thioether compound from thiosulfate, which comprises the following steps: taking thiosulfate as a raw material, sequentially adding a catalyst, a ligand, an additive, alkali and a solvent into a reactor, and reacting in a nitrogen atmosphere to prepare the thioether compound as shown in a formula (II), h on a benzene ring is substituted or not substituted by a substituent R1, R1 is methyl during substitution, and a substituent R2 is benzyl, 4-chlorphenyl, 4-nitrophenyl, 4-methoxyphenyl, 2-fluorophenyl, methyl or benzyl. The method has the advantages of mild reaction conditions, use of cheap and easily available raw materials, and efficient promotion of the preparation of thioether compounds.

The invention discloses a preparation method of 4-bromo-2-(4-chlorphenyl)-5-trifluoromethyl-1H-pyrrole-3-formonitrile, and belongs to the technical field of organic synthesis.The preparation method comprises the steps of acylation reaction, cyclization reaction, bromination reaction and recovery. The preparation method disclosed by the invention is high in safety, the prepared 4-bromo-2-(4-chlorphenyl)-5-trifluoromethyl-1H-pyrrole-3-formonitrile is high in purity and yield, the equipment investment is small, the bromination reaction speed is high, the acid-binding agent can be recycled, the drying time during recycling is short, and the water content in the recycled acid-binding agent is low.

The invention discloses a chlorobenzene wastewater continuous stripping purification recovery device and an implementation method, the chlorobenzene wastewater continuous stripping purification recovery device comprises an aeration tank, an alkali water washing system, an acid water washing system, an acid-base neutralization system and a ferric hydroxide separation system, the aeration tank is connected with the alkali water washing system, the acid water washing system is connected with the alkali water washing system, and the acid water washing system is connected with the ferric hydroxide separation system. The acid-base neutralization system is connected with the alkali-water washing system, the acid-water washing system and the ferric hydroxide separation system, and the alkali-water washing system and the acid-water washing system are both in two-stage steam stripping, and have the following advantages: alkali washing water and acid washing water generated in the chlorobenzene production process are subjected to two-stage nitrogen steam stripping, so that the content of organic matters is greatly reduced; ferric hydroxide is generated through neutralization of acid-alkali wastewater, the total amount of the wastewater is reduced, then the ferric hydroxide reacts with hydrochloric acid in the pickling water to generate ferric trichloride, hydrochloric acid is neutralized, the neutralization product ferric hydroxide is consumed, the wastewater amount is reduced, and recycling of wastewater resources is achieved.

The invention provides a polyolefin elastomer for a photovoltaic packaging film as well as a preparation method and application of the polyolefin elastomer, the polyolefin elastomer is a random or block polymer composed of ethylene and alpha-olefin, the molecular weight Mw of the polyolefin elastomer is 40000-100000, the PDI is 2.3-3, the monomer insertion rate is 20-40 wt%, in TGIC trichlorobenzene heating leaching, the elution peak of polyolefin resin is double peaks, and the molecular weight Mw of the polyolefin elastomer is 25000-25000, the PDI of the polyolefin elastomer is 2.3-3, and the monomer insertion rate of the polyolefin elastomer is 20-40 wt%. The temperature difference between two peaks is 35-50 DEG C, the half-peak width of the peak appearing at the position larger than 40 DEG C is 20-28, the elastomer has high light transmittance and additive absorption capacity, and the prepared composition photovoltaic packaging adhesive film has more excellent optical performance.

The invention discloses a cellulose derivative doped perovskite active layer, a preparation method thereof and a perovskite solar cell, and relates to the technical field of solar cells, and the preparation method comprises the steps: dissolving PbI2, PbBr2, CsI, MABr, FAI and MACl in a solvent to obtain a mixed solution; adding HPMCP into the mixed solution to obtain a perovskite precursor solution; and in a protective gas atmosphere, spin-coating the perovskite precursor solution on a substrate, dropwise adding chlorobenzene in the spin-coating process, and heating the substrate after spin-coating to obtain the perovskite active layer. The method has the beneficial effects that the leakage of lead in perovskite is effectively inhibited by utilizing the physical wrapping effect of HPMCP and the strong coordinate bond effect and hydrogen bond effect of perovskite, the quality of a perovskite active layer thin film can be improved, grain boundary defects are effectively passivated, ion migration is inhibited, and good optical performance is achieved; the photoelectric conversion efficiency and the environmental stability of the halogen hybrid perovskite solar cell device are effectively improved.

The invention discloses a sliding plate brick and a preparation method thereof, and relates to the technical field of sliding plate bricks. The sliding plate brick comprises the following raw materials in parts by weight: 30-50 parts of tabular corundum, 20-30 parts of white corundum, 8-12 parts of graphite, 2-5 parts of carbon black, 3-5 parts of metal aluminum powder, 4-6 parts of a binder and 2-4 parts of silicon carbide. The preparation method comprises the following steps: reacting hydroxyl in sodium alginate with chlorine atoms in 4-chlorophenylboronic acid under the action of potassium carbonate to generate boric acid modified sodium alginate; boric acid bonds in the boric acid modified sodium alginate react with hydroxyl groups in tannic acid to generate tannic acid composite sodium alginate; hydroxyl in the tannic acid composite sodium alginate reacts with silicon hydroxyl in the triphenyl hydroxysilane under the action of phosphoric acid to generate the binder. The prepared sliding plate brick has good compression strength and high-temperature fracture resistance.

The invention discloses a high-impact material prepared from recycled polypropylene and a preparation method of the high-impact material, and relates to the field of materials. When recycled polypropylene is used for preparing the high-impact material, firstly, polypropylene is grafted with vinyl diphenylphosphine, then the grafted polypropylene is reacted with 1-(3-chlorphenyl)-2-propyn-1-ol, and then the reacted polypropylene is reacted with 6-(methyl formate) pyridine-3-boric acid to obtain modified polypropylene; secondly, the calcium carbonate pretreated by 3-aminopropyltrimethoxysilane reacts with 3-thiophenecarboxaldehyde, thiophene, 6-(thiophene-2-yl) pyridine-2-carboxylic acid and 6-(3-thienyl) pyridine-2-formaldehyde are polymerized on the surface of the calcium carbonate, and modified calcium carbonate is obtained; and finally, carrying out melt blending on recycled polypropylene, modified polypropylene, modified calcium carbonate, sodium cyanide and bismaleimide, and carrying out extrusion granulation to obtain the high-impact material. The high-impact material prepared by the invention has good impact resistance, aging resistance and antibacterial property.

The invention discloses a nitrochlorobenzene freezing point detection device and a test method. The device comprises a base, and a test device, a power supply and control module and a freezing module are arranged on the base. A refrigerator is arranged in the freezing module and is used for providing cooling capacity for the test device; the power supply and control module comprises a power supply and a controller; the power supply is used for supplying power to the freezing module and the test device; the test device comprises a fixed table, a lifting driving device, a lifting table, a test container and a bath. The test container comprises a test bottle, a stirrer, a temperature sensor, a torque sensor, a test bottle cap and a dropwise adding meter. The controller judges whether the test sample reaches a freezing point or not according to the torque value of the stirring shaft, when the test sample reaches the freezing point, the controller stores the measured temperature of the temperature sensor, and the temperature is the freezing point temperature of the test sample. The nitrochlorobenzene freezing point detection device can replace manual work to automatically detect the nitrochlorobenzene freezing point, and is high in detection efficiency, high in detection precision and good in repeatability.

There is provided an alkali metal salt of 4-chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide and formulations thereof. This salt finds particular utility in the treatment or prevention of a disorder or condition ameliorated by the activation of AMPK.

A method for preparing 1-(4-chlorphenyl)-3-pyrazole alcohol through air oxidation is characterized in that a eutectic solvent is adopted as a solvent and a catalyst, air oxidation reaction of 1-(4-chlorphenyl) pyrazolidine-3-ketone is dissolved and catalyzed to prepare the 1-(4-chlorphenyl)-3-pyrazole alcohol, the mass ratio of the 1-(4-chlorphenyl) pyrazolidine-3-ketone to the eutectic solvent is (1: 20)-(1: 10), and the mass ratio of the 1-(4-chlorphenyl) pyrazolidine-3-ketone to the eutectic solvent is (1: 20)-(1: 10). The method comprises the following steps of: reacting 1-(4-chlorphenyl)-3-pyrazole alcohol for 3-6 hours at the air flow velocity of 10-40L / min at the reaction temperature of 40-70 DEG C, after the reaction is finished, extracting the product 1-(4-chlorphenyl)-3-pyrazole alcohol for three times by using an extracting agent with the same volume as a reaction mixture, combining extracting solutions, and recovering the extracting agent through reduced pressure distillation to obtain the product 1-(4-chlorphenyl)-3-pyrazole alcohol, the yield is 98.2-99.4%, the purity is 98.7-99.5%, the raffinate is a eutectic solvent, and the method is suitable for industrial production. The direct recycling can be realized. The method has the characteristics of mild reaction conditions, simplicity and convenience in operation and high product yield; the eutectic solvent has dual functions of a solvent and a catalyst, can dissolve reaction raw materials and can provide a catalytic active center for the reaction, and the reaction efficiency is improved through the synergistic effect of the solvent and the catalyst; the eutectic solvent is easy to separate from the product, and the active center is not lost and can be repeatedly used.

The invention discloses a catalytic combustion catalyst for treating CVOCs (Chemical Volatile Organic Compounds) as well as a preparation method and application of the catalytic combustion catalyst. The preparation method comprises the following steps: (1) impregnating and loading cerous nitrate and trimethyl phosphate on a carrier, drying, and roasting at 600-800 DEG C to form a modified carrier containing a cerous phosphate crystal phase; and (2) impregnating and loading active metal ruthenium on the modified carrier, drying and roasting to obtain the catalyst for treating catalytic combustion of the CVOCs. The catalyst provided by the invention can be used for catalytic combustion degradation of CVOCs such as dichloromethane, chlorobenzene, chloroethylene, dichloroethane, dichloroethylene, oxychloropropane and the like. For catalytic combustion degradation of CVOCs, the catalyst disclosed by the invention can show high activity, high chlorine-resistant stability, low polychlorinated by-product selectivity and thermal stability, and has certain industrial application prospects.

The invention relates to the technical field of all-solid-state batteries, in particular to air-stable argyrodite type sulfide electrolyte, a preparation method thereof and an all-solid-state battery. The air-stable argyrodite type sulfide electrolyte provided by the invention comprises a sulfide solid electrolyte and a protective layer formed by self-assembly of organic molecules on the surface of the sulfide solid electrolyte, wherein the sulfide solid electrolyte is argyrodite type sulfide solid electrolyte, the general formula of the sulfide solid electrolyte is Li < 7-a > PS < 6-a > X , X is halogen, and a is more than 0 and less than 2; the organic molecule is at least one of 1-methoxyhexane, 2-heptanone, 3-chloropropanol, 4-chlorobenzyl mercaptan, n-amylamine, 5-chloromethyl-1, 3-benzodioxole, chlorophenylmethane and ethylbenzene, and the organic molecule is at least one of 1-methoxyhexane, 2-heptanone, 3-chloropropanol, 4-chlorobenzyl mercaptan, n-amylamine, 5-chloromethyl-1, 3-benzodioxole, chlorophenylmethane and ethylbenzene. According to the air-stable argyrodite type sulfide electrolyte provided by the invention, the stability of the sulfide electrolyte to water can be enhanced, and the ionic conductivity of the sulfide electrolyte can be ensured.

Provided in the present invention are a method for preparing a polyolefin elastomer and a composition thereof for use in a photovoltaic encapsulation film, and the use of the polyolefin elastomer and the composition. The polyolefin elastomer is a random or block polymer composed of ethylene and α-olefin, wherein the molecular weight Mw of the polyolefin elastomer is 30,000-200,000; the PDI thereof is 1.5-3; the MFR thereof measured under the conditions of a temperature of 190ºC and a load of 2.16 kg is 1-50 g / 10 min; the density thereof is 0.85-0.95 g / cm3; the monomer insertion rate is 10-65 wt%; and during heating and leaching processes of TGIC using trichlorobenzene, the content of soluble substances in a polyolefin resin at 40ºC or lower is 0.1% to 20%. The composition prepared from the elastomer has better optical performance, electrical insulation performance and anti-PID performance when being applied to a photovoltaic encapsulation adhesive film.

The invention discloses a defect passivation perovskite solar cell and a preparation method thereof, and belongs to the technical field of solar cell preparation. The preparation method comprises the following steps: mixing a SnO2 aqueous solution and an organic hydrochloride solution, and carrying out ultrasonic treatment to obtain an organic hydrochloride doped SnO2 precursor solution; preparing a halogen-containing compound solution and an organic salt solution as a perovskite precursor solution; the preparation method comprises the following steps: uniformly mixing Fk209, tBP, Li-TFSI, Spiro-OMeTAD and chlorobenzene or tBP, Li-TFSI, P3HT and chlorobenzene to obtain a hole transport layer precursor solution; the preparation method comprises the following steps: preparing a SnO2 electron transport layer, a perovskite absorption layer and a hole transport layer on a substrate material in sequence, and finally preparing a molybdenum oxide layer and a silver electrode on the hole transport layer. The problem that a large number of defects exist in existing perovskite solar cell preparation is solved, and the carrier transmission capacity and the photoelectric conversion efficiency are improved.

The invention discloses an anti-aging and anti-corrosion coating and a preparation method thereof, and relates to the technical field of coatings. When the anti-aging and anti-corrosion coating is prepared, firstly, tetramethyl tetravinyl cyclotetrasiloxane, n-butyllithium and dimethyl-3-chloropropyl chlorosilane react to obtain modified polysiloxane, then 4-vinylpyridine, methyl methacrylate and n-butyl acrylate are copolymerized and then react with the modified polysiloxane, and then bis (4-chlorphenyl) phosphine is grafted to obtain the anti-aging and anti-corrosion coating. Finally, reacting with p-aminodiphenylamine to obtain modified acrylic resin; secondly, enabling the titanium dioxide nanosheet pretreated by 3-aminopropyltrimethoxysilane to react with ester phthalocyanine, and then hydrolyzing to obtain a modified titanium dioxide nanosheet; finally, mixing the modified acrylic resin, the modified titanium dioxide nanosheet, a solvent, a dispersing agent and a defoaming agent to obtain the anti-aging and anti-corrosion coating. The anti-aging and anti-corrosion coating prepared by the invention has excellent anti-aging, anti-corrosion, flame-retardant and antibacterial properties.

The invention discloses weather-resistant unsaturated polyester resin as well as a preparation method and photovoltaic application thereof, and relates to the technical field of high polymer materials. When the weather-resistant unsaturated polyester resin is prepared, 1, 6-hexanediol, itaconic acid and an ultraviolet absorption monomer are subjected to esterification and polycondensation to prepare unsaturated polyester; the preparation method comprises the following steps: carrying out reaction on naringenin and 4-isocyanate-tetramethylpiperidine oxide to prepare a functional cross-linking agent; the preparation method comprises the following steps: reacting 3-(4-chlorphenyl) phosphine, 2, 2 '-thiobis (4-chlorophenol) and 2-butene-1, 4-diamine, and polymerizing and coating silicon dioxide to prepare pre-modified silicon dioxide; reacting the pre-modified silicon dioxide, n-butylamine and nickel acetate to obtain modified silicon dioxide; uniformly mixing unsaturated polyester, a functional cross-linking agent and modified silicon dioxide, and performing injection molding to obtain the weather-resistant unsaturated polyester resin. The weather-resistant unsaturated polyester resin prepared by the invention has excellent anti-aging, flame-retardant, self-repairing and mechanical properties.

The invention provides a preparation method of an organic electron transport layer and a preparation method of a perovskite solar cell. The perovskite solar cell structurally comprises an anode, a hole transport layer, a perovskite layer, the organic electron transport layer, a cathode modification layer and a cathode from bottom to top. According to the preparation method of the organic electron transport layer, an n-type small organic molecule CY4 solution is dissolved in a PCBM solution according to a certain proportion, chlorobenzene (CB) is adopted as a solution solvent, the perovskite layer is spin-coated with the solution solvent after stirring, a high-quality organic electron transport layer film is formed, and it is measured that the photoelectric conversion efficiency of a final device is 19.80%. A series of characterization results show that the CY4-doped organic electron transport layer improves the electron extraction capability between layers and inhibits carrier recombination; and meanwhile, the roughness of the PCBM film is also reduced, and the formed organic electron transport layer film more uniformly covers the perovskite layer, so that the efficiency of the cell and the environmental stability are greatly improved finally.

The invention discloses 5-chloro-5-phenyl-4, 5-dihydroisoxazole-3-carboxylic acid and a derivative thereof (formula I): # imgabs0 #, and in the formula I, R is selected from H, C1-C6 alkyl and C3-C8 cycloalkyl, preferably H, methyl, ethyl, propyl, isopropyl, cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl. When the compound shown in the formula I is used for synthesizing related active compounds, the synthesis route can be greatly shortened, the yield is increased, and the application prospect is wide.

There is provided an alkali metal salt of 4-chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide and formulations thereof. This salt finds particular utility in the treatment or prevention of a disorder or condition ameliorated by the activation of AMPK.

The invention provides a CeOx-TiO2 catalyst for efficiently catalyzing and degrading chlorine-containing VOCs (Volatile Organic Compounds) as well as a preparation method and application of the CeOx-TiO2 catalyst, and belongs to the field of catalysts. The method comprises the following steps: dispersing a titanium source and a cerium source in deionized water, then adding ammonia water, stirring, filtering and washing until the pH value of filtrate is close to neutral, and drying and roasting to obtain the cerium nano island catalyst CeOx-TiO2 with uniformly dispersed titanium dioxide surface. According to the invention, the zeta negative potential of titanium dioxide and the positive potential of [Ce (OH) x] y < + > interact under an alkaline condition to prepare cerium active sites which are isolated and dispersed on the surface of titanium dioxide, and finally, precursor powder is calcined to prepare the Cl-VOCs catalyst with cerium nano islands dispersed on the surface of titanium dioxide. The Cl-VOCs catalyst prepared by the method has low-temperature purification performance on chlorobenzene and chlorine poisoning resistance, and meanwhile, the sintering resistance of the Ce active component is also effectively relieved.

The invention provides a preparation method of a bexagliflozin intermediate, and relates to the technical field of organic synthesis. The preparation method provided by the invention comprises the following steps: S1, substitution reaction: under the action of alkali, carrying out substitution reaction on 2-(cyclopropoxy) ethanol and a compound III ((5-halogen-2-chlorphenyl) (4-halophenyl) ketone) to generate a compound II; s2, reduction reaction: under the action of lewis acid, carrying out reduction reaction on a reducing agent and a compound II ((5-halogen-2-chlorphenyl) (4-(2-(cyclopropoxy) ethyoxyl) phenyl) ketone) to generate a compound I; the method has the advantages of mild reaction conditions, high atom utilization rate, high yield, high product quality and the like.

The present invention concerns pharmaceutically acceptable salts of (S)-1-(1-(3-chlorophenyl)- 2-(dimethylamino)ethyl)-4-(5-morpholino-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2(1 H)-one of the formula (I) wherein said salt is selected from a hydrochloride salt, a maleate salt, an esylate salt, an oxoglutarate salt, a malonate salt and an oxalate salt.

The invention is applicable to the technical field of chemical purification, and provides a method for preparing p-chlorobenzonitrile by static melt crystallization, which comprises the following steps: melting a p-chlorobenzonitrile crude product from a rectification system into a liquid, and adding the liquid into a layered melt crystallizer for cooling crystallization treatment; carrying out heating sweating treatment on crystals obtained by cooling crystallization treatment, returning obtained sweating liquid and non-crystallized mother liquor to a rectification system for purification, and then adding the obtained sweating liquid and non-crystallized mother liquor into the melt crystallizer again for purification treatment; according to the cooling crystallization treatment procedure, the cooling rate is 1-3 DEG C / h, the cooling end point is 83-86 DEG C, and heat preservation is conducted for 1-1.5 h; the heating sweating treatment procedure is as follows: the heating rate is 0.5-3 DEG C / h, the temperature is increased to 91-93 DEG C, and the constant temperature is kept for 0.5-1 h. The method has the advantages of no need of additional addition of a solvent, no treatment of three wastes, high recovery rate and high product purity, is a green separation and purification process, and has the advantages of simple process, mild operation temperature, simple purification operation, low risk and high production safety coefficient.