9results about How to "Broad spectrum" patented technology

The invention discloses a hepatitis B virus monoclonal neutralizing antibody SY-4 as well as preparation and application thereof. The hepatitis B virus monoclonal neutralizing antibody is SY-4 and consists of a heavy chain and a light chain paired with the heavy chain, the amino acid sequences of the CDR1, the CDR2 and the CDR3 of the heavy chain of the SY-4 are DFSFSSHA, ISSYDGGTT and AKEGNAFRYFGWLPDYQYFGMDV in sequence, and the amino acid sequences of the CDR1, the CDR2 and the CDR3 of the light chain of the SY-4 are QRINSRY, AAS and QQYGNSPLCS in sequence. The hepatitis B virus monoclonal neutralizing antibody SY-4 provided by the invention is an HBV neutralizing antibody, has ADCP activity, can crossly recognize various HBV genotypes HBsAg, has a good biological function, and provides a new candidate antibody for prevention and treatment of hepatitis B virus.

The invention discloses a plant immune induced resistance protein Ps131903 and application thereof. The amino acid sequence of the immune induced resistance protein Ps131903 is shown as SEQ ID NO.2. The protein Ps131903 can reduce the harm of phytophthora sojae and pythium ultimum to soybeans, reduce the harm of phytophthora capsici to chilies and tomatoes and reduce the harm of pyricularia grisea to rice. The compound has the advantages of low use concentration, quick effect and broad spectrum, and provides a new way for improving the plant resistance, thereby having wide application prospects in agricultural production.

The invention discloses an application of an inhibitor of a HAND2 gene or a HAND2 protein in preparation of an anti-hepatic fibrosis drug, and relates to the technical field of biological medicines, the application of the inhibitor of the HAND2 gene or the HAND2 protein in preparation of the anti-hepatic fibrosis drug, and the inhibitor is an inhibitor for inhibiting expression of the HAND2 gene or an inhibitor for inhibiting activity of the HAND2 protein; the inhibitor is selected from at least one of the following components: a small molecule compound, siRNA, shRNA, antisense oligonucleotide, a nucleic acid aptamer, a CRISPR gene editing system or a neutralizing antibody aiming at HAND2 protein and an antigen binding fragment of the neutralizing antibody; the inhibitor is siRNA (small interfering ribonucleic acid) or shRNA (short hairpin ribonucleic acid) of a targeted HAND2 gene; according to the application, the key effect of the HAND2 as a new target spot for treating the hepatic fibrosis is confirmed, and the field blank is filled; a clear, specific and enforceable technical scheme is provided, the spanning from target spot discovery to therapeutic drug application is realized, and a solid basis is provided for developing novel drugs.

The utility model provides a kind of advanced oxidation device for wastewater treatment belongs to water treatment technical field, and it includes: jar body, multiple layers honeycomb catalyst layer are provided in jar body, and the periphery of each catalyst layer is formed fixed frame by surrounding multiple porous ceramic plates;Each porous ceramic plate is evenly coated with nano TiO2 Particle;The top of jar body is arrayed with multiple ultraviolet LED fluorescent tubes;Water inlet is equipped on the lower part side wall of jar body, and microporous aerator is arranged at the bottom of jar body;Microporous aerator is imported ozone into jar body;TiO2 modified graphite electrode is symmetrically embedded on the side wall of jar body.The advanced oxidation device couples multiple advanced oxidation processes, under the joint action of photocatalytic reaction, ozone oxidation, electrochemical oxidation, speeds up the generation rate of hydroxyl radical, improves the utilization efficiency of active component hydroxyl radical, can efficiently remove refractory organic matter in wastewater, reaches the effect of synergistic effect, improves degradation efficiency.

The invention belongs to the field of medicine preparation, and particularly relates to a nano delivery carrier of IL-22BPmRNA (Interleukin-22BPmRNA). The invention aims to overcome the defect of less types of ionizable phospholipids for preparing LNP delivery mRNA. The technical scheme for solving the technical problem is to provide a nano delivery carrier of IL-22BPmRNA, which is prepared on the basis of a novel ionizable phospholipid molecule capable of being used for preparing a nucleic acid delivery carrier. The nano delivery carrier of the IL-22BPmRNA, disclosed by the invention, is good in stability. Experiments show that therapeutic RNA can be efficiently delivered to various human and mouse tumor cells, high-level protein expression is realized, and the polypeptide has unique advantages and good application prospects in the field.

This invention specifically relates to a composite polymer antibacterial agent, its preparation method, and its application, belonging to the field of antibacterial materials technology. The antibacterial agent, by weight percentage, comprises a core component PQ-1 (0.01%~0.1%), a synergistic component polyhexamethylene biguanide (PHMB) (0.005%~0.05%), a synergistic component polyaminopropyl biguanide (PAPB) (0.005%~0.05%), and the balance being solvent. This invention, through the synergistic combination of PQ-1 and the two synergistic components, can reduce the minimum inhibitory concentration (MIC) against typical microorganisms by more than 75% while reducing the amount of PQ-1 by 50%~80%, achieving optimized protection of the antibacterial efficacy concentration of PQ-1, while also possessing the advantages of broad spectrum, stability, mildness, and low toxicity. Its preparation process is simple and can be widely applied in ophthalmic preparations, cosmetics, and other fields, demonstrating extremely high practical value.

The application discloses a kind of domestic waste incineration fly ash washing dechlorination system and process, including fly ash deep dechlorination reactor and with the dechlorination agent dosing device of fly ash deep dechlorination reactor, stirring device, micro-nano aeration device, electrolytic device power supply and temperature control device.The application provides the treatment process for significantly reducing the chlorine content in fly ash by aiming at the dechlorination treatment needs of waste incineration fly ash washing end, and provides significant convenience conditions for the resource utilization of domestic waste incineration fly ash.The main innovation of the process is that after four processes of break point dechlorination, fugitive dechlorination, catalytic oxidation dechlorination and electrolytic dechlorination, the chlorine content in waste incineration fly ash can be significantly reduced.After the process treatment, the chlorine content in fly ash after fly ash washing dechlorination process treatment can be less than 0.1%, which is much lower than the chlorine content in fly ash after waste incineration fly ash washing after countercurrent rinsing, and the process runs stably.

This invention relates to an Au@PDA / Pt nanozyme, its preparation method, and its application in the detection of carbofuran pesticides. The nanozyme comprises an Au@PDA composite material and platinum nanoparticles loaded thereon. The Au@PDA composite material includes a gold core layer formed by the aggregation of multiple gold nanoparticles and a polydopamine shell coating the gold core layer. The platinum nanoparticles are uniformly loaded on the polydopamine shell. This nanozyme is used to obtain an Au@PDA / Pt nanozyme probe by conjugating a group-selective carbofuran antibody. Furthermore, this invention constructs an immunochromatographic detection method for carbofuran pesticides based on this Au@PDA / Pt nanozyme probe and an immunochromatographic test strip used in conjunction with it. Compared with existing technologies, the detection method of this invention has broad-spectrum recognition capability and high sensitivity, and can complete the detection of carbofuran pesticides such as carbofuran, 3-hydroxycarbofuran, thiocarbofuran, prothiocarbofuran, and oxadiazon within 6 minutes. Moreover, the test strip has a simple structure and the probe is easy to synthesize.

The invention discloses an antigen combination of influenza virus and application thereof. According to the invention, the multivalent influenza vaccine aiming at H1N1, H3N2 and BV strains is developed by screening and optimizing sequence codons and proportions. Compared with inactivated split vaccines on the market, the multivalent influenza mRNA vaccine developed by the invention has excellent immunogenicity and protective efficacy, and has broad spectrum and immune persistence. According to the combined vaccine, the influenza vaccine and the SARS-CoV-2 virus vaccine are integrated into the combined vaccine, so that influenza and SARS-CoV-2 virus infection can be prevented at the same time, and the inoculation needle frequency is reduced.