2472 results about "Alkyne" patented technology

A precursor source mixture useful for CVD or ALD of a film comprising: at least one precursor composed of an element selected from the group consisting of Li, Na, K, Rb, Cs, Fr, Be, Mg, Ti, Zr, Hf, Sc, Y, La, V, Nb, Ta, Cr, Mo, W, Mn, Re, Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt, Cu, Ag, Au, Zn, Cd, Hg, B, Al, Ga, In, Tl, Si, Ge, Sn, Pb, As, P, Sb and Bi, to which is bound at least one ligand selected from the group consisting of hydride, alkyl, alkenyl, cycloalkenyl, aryl, alkyne, carbonyl, amido, imido, hydrazido, phosphido, nitrosyl, nitryl, nitrate, nitrile, halide, azide, alkoxy, siloxy, silyl, and halogenated, sulfonated or silyated derivatives thereof, which is dissolved, emulsified or suspended in an inert liquid selected from the group consisting of aliphatic hydrocarbons, aromatic hydrocarbons, alcohols, ethers, aldehydes, ketones, acids, phenols, esters, amines, alkylnitrile, halogenated hydrocarbons, silyated hydrocarbons, thioethers, amines, cyanates, isocyanates, thiocyanates, silicone oils, nitroalkyl, alkylnitrate, and mixtures thereof. The precursor source mixture may be a solution, emulsion or suspension and may consist of a mixture of solid, liquid and gas phases which are distributed throughout the mixture.

This invention relates to the field of olefin polymerization catalyst compositions, and methods for the polymerization and copolymerization of olefins, typically using a supported catalyst composition. In one aspect, this invention encompasses precontacting a metallocene with an olefin or alkyne monomer and an organoaluminum compound, prior to contacting this mixture with the acidic activator-support.

The present invention provides for a practical, universal and efficient method to ligate two large macromolecules (e.g., proteins) using the alkyne-azide 1,3-dipolar cycloaddition reaction to produce a conjugated macromolecule, such as a multivalent scFv. The present invention also provides for conjugate macromolecules comprising a plurality of macromolecule components cross-linked through at least one linking group comprising at least one 1,2,3-triazole moiety, wherein at least 50 percent of the macromolecule components in the conjugate macromolecule has only one site available for cross-linking.

A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt or copper metal. The process is preferably carried out in a solvent, such as an aqueous alcohol. Optionally, the process can be performed in a solvent that comprises a ligand for Cu(I) and an amine.

The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such as p-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2] cycloaddition reactions and Staudinger modifications.

The invention relates to a selective hydrogenation method of high unsaturated hydrocarbons in C4 fractions, which is characterized in that salvage stores which are rich in acetylene hydrocarbon and prepared by extracting butadiene are used as the material, and a fixed bed reactor is adopted to obtain 1, 3-budiene by selective hydrogenation under the existence of a catalyst. The adopted process conditions are as follows: the reaction temperature is between 30 DEG C and 90 DEG C, the reaction pressure is between 1.0 MPa and 4.0 MPa and the liquid space velocity is 7 to 20h<-1>. The catalyst is preferably a palladium system catalyst with alumina as a carrier, the specific surface is 50 to 150m<2> / g and the specific pore volume is 0.25 to 1.0ml / g. The method has remarkable good effects on reducing waste of resources and improving economic benefits by effectively utilizing the salvage stores rich in acetylene hydrocarbon and prepared by extracting butadiene.

The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such asp-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2]cycloaddition reactions and Staudinger modifications.

The present invention provides a method for the covalent immobilization of biomolecules on polymers for delivery of the biomolecules, which has the advantage of being simple, highly efficient, environmentally friendly and free of side products relative to traditional immobilization techniques. The invention provides a modified micro / nanoparticle system, which uses a functionalized polymer formed into micro or nanoparticles to bind a molecule to the particles using uses facile chemistry, the Diels-Alder cycloaddition between a diene and a dienophile with the polymer being functionalized with one of them and the molecule with the other, or the Huisgen 1,3-dipolar cycloaddition between a terminal alkyne and an azide to bind the molecule to the particle. The molecules and / or other therapeutic agents may be encapsulated within the polymer particles for intravenous therapeutic delivery. The invention also provides a novel synthetic biodegradable polymer, a furan / alkyne-functionalized poly(trimethylene carbonate) (PTMC)-based polymer, whose composition can be designed to meet the defined physical and chemical property requirements. In one example, the particle system self-aggregates from functionalized PTMC-based copolymers containing poly(ethylene glycol) (PEG) segments. The composition of the copolymers can be designed to meet various particle system requirements, including size, thermodynamic stability, surface PEG density, drug encapsulation capacity and biomolecule immobilization capacity.

The invention relates to a non-noble metal supported selective hydrogenation catalyst and a preparation method and application thereof. The catalyst comprises a carrier, and a main active component and an auxiliary active component which are loaded on the carrier, wherein the main active component is nickel, and the auxiliary active component is at least one of Mo, La, Ag, Bi, Cu, Nd, Cs, Ce, Zn and Zr; and the active components exist in amorphous forms, the average grain diameter is less than 10 nanometers, and the catalyst is prepared by a micro-emulsion method. The catalyst has evenly distributed active components and high dispersity, and can resist the erosion of poisonous materials of arsenium, sulfur and the like. The catalyst has good hydrogenation performance which is higher than that of the prior level of the conventional non-noble metal catalyst and is close to the level of a noble metal Pd catalyst in the reaction for removing acetylene hydrocarbon through C2 selective hydrogenation.

A reagent for oligonucleotide synthesis or purification, wherein the reagent has a structure of:X—C-L-H  (Formula A)wherein X is a phosphoramidite group, an H-phosphonate group, an acetal group, or an isocyanate; C is a direct bond or a cleavable adaptor represented by —Ca-Cb—; L is a hydrocarbyl chain; and H is a terminal alkyne or an activated cyclooctyne. The reagent of Formula (A) can be used in the synthesis and purification of oligonucleotides.

A process for the liquid phase selective hydrogenation of alkynes to alkenes with high selectivity to alkenes relative to alkanes, high alkyne conversion, and sustained catalytic activity comprising a reactant comprising an alkyne and a non-hydrocarbon solvent / absorbent, contacting the reactant stream with a hydrogen-containing stream in the presence of a supported, promoted, Group VIII catalyst, removing the solvent / absorbent, and recovering the alkene product.

The invention belongs to the field of medicinal chemistry, and discloses pyrimidine compounds containing semicarbazide and terminal alkyne structural units, and preparation methods and applications of the pyrimidine compounds in preparation of antitumor drugs by taking lysine specific demethylase 1 (hereafter referred to as LSD1) as a target. A pyrimidine active fragment is built by adopting a three-component one-pot method, and then the target compounds are prepared by substitution, chlorination and ammonification reaction. The general formulas of the compounds are as shown in the formula I in the specification. An in vitro anti-tumor activity experiment and an LSD1 inhibition activity experiment prove that the compounds have obvious inhibiting and killing action on a plurality of tumor cells by inhibiting the activity of the LSD1, can be used as lead compounds for further development, and are applied to preparation of the antitumor drugs.

The present disclosure provides compositions which may be utilized as adhesives or sealants in medical and surgical applications. The compositions may, in embodiments, be formed from the cycloaddition reaction of a first component possessing at least one azide group with a second component possessing at least one alkyne group.

The invention relates to preparation of a supported catalyst for 1,4-butynediol. The supported catalyst used is characterized in that a mesoporous molecular sieve is used as a carrier, and soluble copper salt and bismuth are loaded on the carrier by an impregnation method so that the mass content of copper in the catalyst is 15-30%, and the mass content of bismuth is 1-6%. In the prepared catalyst, the particle size of copper oxide is 10-80nm, and the bismuth oxide is amorphous powder; the copper oxide and the bismuth oxide are uniformly distributed on the carrier and interact with the carrier; and the catalyst has high activity and high selectivity in producing 1,4-butynediol through an alkyne hydroformylation reaction, is more stable and wear-resistant than similar catalysts, and saves copper resources.

The average cycle propylene selectivity of an oxygenate to propylene (OTP) process using one or more fixed or moving beds of a dual-function oxygenate conversion catalyst with recycle of one or more C4+ olefin-rich fractions is substantially enhanced by the use of selective hydrotreating technology on these C4+ olefin-rich recycle streams to substantially eliminate detrimental coke precursors such as dienes and acetylenic hydrocarbons. This hydrotreating step helps hold the build-up of detrimental coke deposits on the catalyst to a level which does not substantially degrade dual-function catalyst activity, oxygenate conversion and propylene selectivity, thereby enabling a substantial improvement in propylene average cycle yield. The propylene average cycle yield improvement enabled by the present invention over that achieved by the prior art using the same or a similar catalyst system but without the use of the hydrotreating step on the C4+ olefin-rich recycle stream is of the order of about 1.5 to 5.5 wt-% or more.

The invention relates to a selective hydrogenation process for a C4 material flow with high concentration of butadiene. The selective hydrogenation process comprises the following steps of: enabling the C4 material flow with the high concentration of butadiene to pass through one or more fixed bed hydrogenation reactors (I) with circulation pipelines, carrying out a selective hydrogenation reaction on the C4 mixture with high concentration of butadiene under the action of a catalyst to remove the butadiene and alkyne and generate butylene, enabling the reactor to pass through a terminal reactor (II) without the circulation pipeline, and further removing the residual butadiene and alkyne from the C4 material flow with the low concentration of butadiene. By utilizing the selective hydrogenation process and the catalyst provided by the invention, the controlled concentration range of the butadiene and the C4 alkyne of the C4 material flow is 5-80wt%, the concentrations of the butadiene and the alkyne of the hydrogenated C4 material flow can be respectively reduced to below 10ppm, the selectivity of the 1-butene generation by the butadiene can be more than 50%, and the butadiene can be taken as the raw material of preparing the 1-butene. According to the selective hydrogenation process disclosed by the invention, the C4 material flow is reasonably utilized.

A composition and method for preparation of a catalyst for the liquid phase selective hydrogenation of alkynes to alkenes with high selectivity to alkenes relative to alkanes, high alkyne conversion, and sustained catalytic activity comprising a Group VIII metal and a Group IB, Group IIB, Group IIIA, and / or Group VIIB promoter on a particulate support.

The use of a selective chemical and bioorthogonal reaction providing a covalent ligation such as the [3+2] cycloaddition, in targeted molecular imaging and therapy is presented, more specifically with interesting applications for pre-targeted imaging or therapy. Current pre-targeted imaging is hampered by the fact that it relies solely on natural / biological targeting constructs (biotin / streptavidin). Size considerations and limitations associated with their endogenous nature severely limit the number of applications. The present invention describes how the use of an abiotic, bio-orthogonal reaction which forms a stable adduct under physiological conditions, by way of a small or undetectable bond, can overcome these limitations.

An etch process that includes removing an oxide containing surface layer from a semiconductor surface to be etched by applying a hydrofluoric (HF) based chemistry, wherein the hydrofluoric (HF) based chemistry terminates the semiconductor surface to be etched with silicon-hydrogen bonds, and applying a vapor priming agent bearing chemical functionality based on the group consisting of alkynes, alcohols and a combination thereof to convert the silane terminated surface to a hydrophobic organic surface. The method continues with forming a photoresist layer on the hydrophobic organic surface; and patterning the photoresist layer. Thereafter, the patterned portions of the photoresist are developed to provide an etch mask. The portions of the semiconductor surface exposed by the etch mask are then etched.

An etch process that includes removing an oxide containing surface layer from a semiconductor surface to be etched by applying a hydrofluoric (HF) based chemistry, wherein the hydrofluoric (HF) based chemistry terminates the semiconductor surface to be etched with silicon-hydrogen bonds, and applying a vapor priming agent bearing chemical functionality based on the group consisting of alkynes, alcohols and a combination thereof to convert the silane terminated surface to a hydrophobic organic surface. The method continues with forming a photoresist layer on the hydrophobic organic surface; and patterning the photoresist layer. Thereafter, the patterned portions of the photoresist are developed to provide an etch mask. The portions of the semiconductor surface exposed by the etch mask are then etched.

Oligonucleotide chemistry is central to the advancement of core technologies such as DNA sequencing, forensic and genetic analysis and has impacted greatly on the discipline of molecular biology. Oligonucleotides and their analogues are essential tools in these areas. They are often produced by automated solid-phase phosphoramidite synthesis but it is difficult to synthesize long DNA and RNA sequences by this method. Methods are proposed for ligating oligonucleotides together, in particular the use of an azide-alkyne coupling reaction to ligate the backbones of oligonucleotides together to form longer oligonucleotides that can be synthesized using current phosphoramidite synthesis methods.

The present invention provides a substrate of TGase represented by (fluorescent group)-(linker)-(a portion containing a Gln residue capable of recognition by transglutaminase (TGase))-R, wherein the fluorescent group is fluorescein isothiocyanate (FITC), Texas Red (TE) or dansyl (Dns) or a group derived therefrom; the linker is a group represented by —NH—(CH2)n—CO— (n is an integer of 1 to 6); the portion containing a Gln residue capable of recognition by TGase is a group derived from a peptide selected from among QG and the like; and R is a hydroxyl group, or biotin, nucleic acid, azide, alkyne, maleimide or cyclopentadiene, or a group derived therefrom.

The invention discloses an egg- shell metallic catalyst and the method for preparation and the application. The catalyst is an egg- shell supported metallic catalyst with a carrier of hollow silica dioxide, which is a hollow material of certain wall and bore diameter, and comprises a noble metal of 0.1%- 5.0% and / or a transient metal of 5.0%- 40.0%, a non- noble metallic catalyst promoter of 0- 0.5% and a hollow silica dioxide carrier of 60.0%- 99.0%, with the weight ratio of catalyst as a datum level. The egg- shell metallic catalyst can prepare with immersion method or in- situ supporting method. The catalyst has good metal dispersibility, and the metal particle diameter is minor, dispersing on the external surface, inner surface and in the pore passage. And the egg- shell metallic catalyst can catalyze CO and CO2 to prepare lower carbon number hydrocarbons and alcohol, and it also can catalyze olefin and alkyne selectively.

A reagent for oligonucleotide synthesis or purification, wherein the reagent has a structure of:X—C—L—H  (Formula A)wherein X is a phosphoramidite group, an H-phosphonate group, an acetal group, or an isocyanate; C is a direct bond or a cleavable adaptor represented by —Ca—Cb—; L is a hydrocarbyl chain; and H is a terminal alkyne or an activated cyclooctyne. The reagent of Formula (A) can be used in the synthesis and purification of oligonucleotides.

A method for producing a catalyst, in particular for the selective reduction of acetylenic compounds in hydrocarbon streams. An impregnation solution is provided, which contains a mixture of water and at least one water-miscible organic solvent as solvent in which at least one active metal compound and also preferably at least one promoter metal compound is dissolved. A support is provided, the support is impregnated with the impregnation solution, and the impregnated support is calcined. Palladium is preferably used as active metal and silver is preferably used as promoter metal. Also, a catalyst as is obtained by the method and also its preferred use for the selective hydrogenation of acetylenic compounds.

The present invention relates to a process for separating the isoprene, 1,3-pentadiene and dicyclopentadiene from a C5 cuts, comprising dimerization of the cyclopentadiene and selective catalytic hydrogenation. The second extractive rectification step can be omitted, because the alkynes are removed through selective catalytic hydrogenation prior to the extractive rectification. As a result, the solvent-recovering units can be simplified, and thus the process as a whole can be optimized. Correspondingly, the investment and energy consumption, the operation cost, and finally the production cost can be substantially reduced.

Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which attaches the linker to the acceptor dye.

The present invention relates to a palladium-containing alloy single atom catalyst for selective hydrogenation of alkyne. According to the catalyst, an inert oxide SiO2 is adopted as a carrier, Pd and one or two or more than two materials selected from metal elements in group IB or Group VIII excluding Pd are combined to prepare the supported palladium-containing alloy catalyst so as to make the Pd be in the complete or partial single atom distribution state, wherein the Pd accounts for 0.002-1% of the weight of the carrier, and the content of other metal elements accounts for 0.2-8% of the weight of the carrier. The palladium-containing alloy single atom catalyst has characteristics of high catalytic hydrogenation activity, high ethylene selectivity and the like, and has the good reaction catalysis performance in the reaction for preparing ethylene gas to eliminate trace acetylene through petroleum cracking under the condition close to the industrial condition.