91 results about "Alkyne" patented technology

Provided are compounds of Formula I:nucleosides, nucleoside phosphates and prodrugs thereof, wherein R6 is CN, ethenyl, 2-haloethen-1-yl, or (C2-C8)-alkyn-1-yl. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.

The application provides a kind of sodium sulfide nine hydrate and activated olefin / acetylene preparation polyether and its method, belong to sulfur-containing polymer technical field.The structural formula of polyether in the application, R 1 And R 2 Independently be substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl;The number of carbon atoms of the alkyl is 1-10, the number of carbon atoms of alkoxy is 1-10, the number of carbon atoms of aryl is 1-30, the number of carbon atoms of heteroaryl is 3-30;Substituted alkyl and substituted alkoxy independently are one or more;N is an integer of 2-4000.The application is used as sulfur source sodium sulfide nine hydrate, under the condition of no metal catalyst, polyether is synthesized by polymerization reaction;Reaction condition is mild, reaction is efficient, economic and environmental protection, meet the current green production concept and can avoid the use of dangerous reagent.

This invention belongs to the field of photocrosslinking probe technology, specifically relating to a GUSB photocrosslinking probe, its preparation method, and its application. The GUSB photocrosslinking probe has the general chemical formula C0. 13 H 18 N2O6-R, wherein R is any one of the oxalic group elements or peptide bonds. The R group covalently connects the glucuronic acid recognition core and the photosensitive unit in the GUSB photocrosslinking probe, and the R group contains no more than 4 atoms, resulting in a small size and low steric hindrance. The GUSB photocrosslinking probe provided by this invention uses glucuronic acid as the recognition core, combined with a small-volume diazacyclopropane photosensitive unit and a terminal alkyne group, to achieve µM-level in-situ covalent capture of active GUSB in complex systems such as cells or tissues. The probe of this invention significantly improves positioning accuracy, sensitivity, data availability, quantification, and enrichment, while also possessing advantages such as modular synthesis, mild conditions, and strong system compatibility, effectively addressing the technical shortcomings of existing technologies that struggle to accurately obtain GUSB activity in situ under low-dose conditions.

The application belongs to the technical field of catalytic synthesis, and particularly relates to application of a Lewis acid-base pair in catalyzing polymerization of functionalizable monomers. Common polymerization methods have poor controllability for polymerization of monomers containing polyene groups, alkyne groups and conjugated diene groups, and the molecular weight of the obtained polymer is uncontrollable at low monomer conversion, and the molecular weight distribution is wide, and crosslinking occurs at high monomer conversion. The application utilizes a specific Lewis acid-base pair, and by adjusting the electronic effect and steric hindering effect of the Lewis acid and the Lewis base, active controllable polymerization of the functionalizable monomers can be catalyzed, and a polymer with a clear structure and containing functionalizable sites is obtained, the molecular weight is controllable, the molecular weight distribution is narrow, the end group structure is controllable, the position and density of the functionalizable sites are conveniently adjusted, an efficient platform is provided for post-modification preparation of functional high molecular materials, and functional high molecular materials are prepared by combining click reaction.

This invention discloses a cross-linked cyclodextrin polymer, its preparation method, and its applications, belonging to the field of compound synthesis and separation enrichment technology. This invention employs a Sonogashira coupling reaction to react α, β, and γ cyclodextrins with 2-, 3-, or 6-position fully iodine-substituted cyclodextrins with polyalkynyl groups, respectively, to obtain cross-linked cyclodextrin polymers with large specific surface areas and numerous cyclodextrin cavities. These polymers exhibit good separation effects for organic dyes, small organic molecule pollutants, and harmful components in cigarette smoke.

A drug-polymer conjugate, which is a copolymer of at least one monomer of formula (I) where: X may be the same or different at each occurrence and represents a terminal functional group comprising an alkyne or an azide; Q is independently selected at each occurrence and may be present or absent and when present, represents a linking group; R is selected from the group consisting of linear or branched hydrocarbon, optionally substituted aryl and optionally substituted heteroaryl; D is a releasable bicyclic prostaglandin; L is a linker group; and at least one co-monomer of Formula III J-(Y1-A)n, J represents a linking functional group, n is 2 to 8 preferably 3 to 8; Y1 comprises a polyether of formula (ORa)m wherein Ra is independently ethylene, propylene and butylene and m is from 1 to 300 (preferably 2 to 300) and the polyether is in chain with one or more groups which are preferably selected from one or more of optionally substituted straight or branched C1 to C10 alkylene, amino, ether, ester, amide, carbonate and carbamate; A may be the same or different at each occurrence and represents a group comprising a terminal functional group comprising an alkyne or an azide functionality, wherein said terminal functional group is complementary to the terminal functional group X of formula (I) providing triazole moieties from reaction of X and A.

This invention discloses a method for preparing 4-(trifluoromethylsulfinyl)pyrazole compounds, comprising: dissolving terminal alkyne in n-hexane under nitrogen atmosphere, adding anhydrous zinc chloride, and reacting trifluoromethylsulfinyl chloride to obtain α-trifluoromethylalkynyl sulfoxide; adding benzoyl chloride dropwise to a CH2Cl2 solution of phenylhydrazine and triethylamine under nitrogen atmosphere to obtain acylhydrazine; adding carbon tetrachloride to a suspension of acylhydrazine and triphenylphosphine in acetonitrile to obtain hydrazone chloride; and reacting α-trifluoromethylalkynyl sulfoxide, hydrazone chloride, potassium carbonate, and anhydrous ethanol at room temperature to obtain 4-(trifluoromethylsulfinyl)pyrazole compounds. This invention uses inexpensive and readily available raw materials, the entire reaction route is mild and simple to operate, does not require stringent reaction conditions, and most of the reaction process is carried out at room temperature. The product yield is high, and the prepared trifluoromethylalkynyl sulfoxide pyrazole structure has multiple derivatization sites, showing good application prospects.

This invention relates to the field of selective hydrogenation technology, specifically to a selective hydrogenation catalyst for alkynes and dienes, its preparation method, and its application. The catalyst provided by this invention uses a modified composite oxide as a support, on which active components are loaded; wherein the modified composite oxide uses a composite oxide as a support, on which alkali metal hydroxides are loaded; the composite oxide includes alumina and zirconium oxide; the active components include nickel, iron, lead, and selenium. The catalyst provided by this invention not only possesses high reactivity and high selectivity, but also avoids excessive hydrogenation to form alkanes, while inhibiting or preventing olefin isomerization to form other isomers. Furthermore, it exhibits high stability, a long single-pass life, and does not require frequent regeneration.

The application discloses a bisoxazoline pyridine functionalized porous organic polymer and preparation and application thereof; firstly, a styryl functionalized PyBox monomer (VPyBox) is designed and synthesized, and VPyBox, styrene and divinylbenzene are subjected to free radical polymerization under initiation of azobisisobutyronitrile in a certain proportion to obtain a series of porous organic polymers (POP-PyBox); the POP-PyBox can be used as a solid N , N , N tridentate ligand for Co-catalyzed hydrosilylation of arylalkynes with diphenylsilane; the heterogeneous catalyst system developed by the application has a catalytic activity comparable to that of a homogeneous catalyst reported in the literature, and the catalyst is easy to separate and recover; the recovered catalyst can be recycled for more than 6 times, which can not only greatly reduce the preparation cost of vinylsilane, but also simplify the post-treatment process and reduce the three wastes, and has a good practical application prospect.

The application discloses a method for synthesizing a chiral secondary phosphine oxide with a conjugated dienyl phosphorus center through desymmetrization. The method is that a primary phosphine oxide reacts with an alkyne to obtain the chiral secondary phosphine oxide with the conjugated dienyl phosphorus center under the joint catalysis of zero-valent nickel and a ligand and the action of an additive. The method realizes the preparation of the chiral secondary phosphine oxide with the conjugated dienyl phosphorus center with high enantioselectivity and specific chemical selectivity through the joint catalysis of the zero-valent nickel and the ligand.

A selective hydrogenation method for ethane cracking to olefins involves selectively hydrogenating the ethylene feedstock from the top of an ethane stripper to remove acetylene. Reaction conditions: inlet temperature 50℃~95℃, pressure 1.5~3.0MPa, space velocity 8000~14000h⁻¹ ‑1 The preferred reaction conditions are: reactor inlet temperature 60℃~90℃, reaction pressure 2.0~2.5MPa, and space velocity 9000~12000h⁻¹. ‑1 The catalyst support is alumina or mainly alumina, and has a bimodal pore structure. The specific surface area of ​​the catalyst is 3–16 m². 2 The catalyst contains at least Pd, Fe, Ni, and Cu, with Pd supported in both microemulsion and solution formats. Ni and Cu are supported in microemulsion, while Fe is supported in solution. The solution-supported Pd and Fe are primarily located in the 56–75 nm micropores, while the microemulsion-supported Ni, Cu, and Pd are mainly distributed in the 300–650 nm macropores of the support. This alkyne removal method exhibits excellent catalytic performance and anti-coking properties, with low "green oil" formation.

The application discloses a new method for synthesizing 3-acyl imidazo[1,5-a]pyridine compounds. The method comprises the following steps: adding 2-pyridyl-p-methanequinone (2-Py-p-QMs), terminal alkyne and p-toluenesulfonyl azide (TsN3), catalyst CuI, organic solvent and alkali into a reaction container under the condition of RT and O2 atmosphere, stirring the reaction for 4 hours, and then separating and purifying 3-acyl imidazo[1,5-a]pyridine compounds after the reaction is completed. The method expands the structure range of 3-acyl imidazo[1,5-a]pyridine products, and more compounds with rich structures can be obtained. Compared with the previous method for synthesizing the target product, the method is efficient, the reaction reagent is non-corrosive, the method design is novel, the raw material is cheap, the operation method is simple, and the product can be directly obtained under mild conditions.

The application relates to the technical field of textile dyeing and finishing, and particularly discloses a foam nickel loaded nitrogen-doped carbon nanotube / Mn-Zn-P alloy composite material, a preparation method and application thereof. The preparation method is as follows: a calcium carbonate / Ni-Fe alloy layer is prepared on the surface of foam nickel; then, an organic alcohol amine and an alkyne substance are used as a nitrogen source and a carbon source to pre-deposit a nitrogen-containing carbon layer, and subsequently, N2-NH3 and N2-ethylene mixed gas is sequentially introduced to carry out stage-by-stage chemical vapor deposition, so that a Ni / nitrogen-doped carbon nanotube array is obtained; finally, Mn-Zn-P alloy particles are loaded through constant-current electrodeposition. The composite material prepared by the application has high conductivity, excellent corrosion resistance and cycle stability, and provides an ideal electrode material for electrocatalytic hydrogenation reduction, and can be directly used as an indigo reduction electrocatalytic electrode, so that the application has wide industrial application prospects in the field of blue jean dyeing.

This invention discloses a polyvinyl alcohol-modified multifunctional powder slump retainer and its preparation method. The preparation method is as follows: First, polyvinyl alcohol is etherified with p-halogenated benzoic acid to prepare a carboxyl-containing intermediate; second, the carboxyl-containing intermediate is amidated with an amino-terminated modified polyether to prepare a long-side-chain intermediate; then, the long-side-chain intermediate is activated by ortho-C-H oxidation with benzamide, and then coupled with a functional alkyne to form a ring to construct a functional group, thus preparing the target slump retainer; finally, the slump retainer is sliced ​​and pulverized using a slicer and a pulverizer, respectively, to obtain the powder slump retainer. This method uses widely available raw materials, and the preparation process is simple and safe; the product has a long shelf life; the product contains no anti-caking agents and other components, and has a fast dissolution rate, which can significantly reduce transportation costs; the product also has advantages such as antibacterial properties, reduced concrete shrinkage in the later stages, and high water retention; and the product has stable performance and can be stored for a long time.

This invention relates to the field of alkali metal-based battery technology, and particularly to a fluorinated cyclic triphosphazene compound, a flame-retardant electrolyte, and an alkali metal-based battery. The fluorinated cyclic triphosphazene compound provided by this invention has the general structural formula shown in Formula I: Formula I; R1~R6 are each independently selected from -F or ; and one or two of R1~R6 are ; R7 is selected from substituted or unsubstituted alkylene groups, substituted or unsubstituted chain ether groups, substituted or unsubstituted cyclic ether groups; substitution means that at least one hydrogen in the group is independently replaced by a halogen, cyano, olefinic, or alkyne group. This invention applies a fluorinated cyclic triphosphazene compound containing a specific difluoromethyl terminal group to a flame-retardant electrolyte. Utilizing the unique hydrogen bonding and supramolecular halogen bonding interactions between the molecules of this compound, a stable phosphazene supramolecular network is formed inside the electrolyte, thus simultaneously ensuring battery safety, high-voltage stability, and high-temperature adaptability.

The application discloses a cannabidiol derivative and application thereof, and belongs to the technical field of medicinal chemistry. The structural general formula of the cannabidiol derivative is shown as formula (I): (I) R1 is selected from one of hydrogen, chlorine, bromine, a hydroxyl group, a cyano group, an acetoxy group, an acryloyloxy group, a benzoyl group, an acetamide group, an acrylamide group, a propiolamide group, an ethyl thiourea group, a 3-chloro-2,2-dimethylpropionyl group, a 2-ethylsulfonamide acetyl group, a 2-ethylsulfonamide-N-(2-amino-2-oxoethyl) acetyl group, a methylsulfonyl group, an ethylsulfonyl group, a vinylsulfonyl group, an alkyne propylsulfonyl group, a phenylsulfonyl group and a styrylsulfonyl group; and R2 is selected from one of C2-C5 alkyl groups. The cannabidiol derivative disclosed by the application has significantly improved anti-neuroinflammatory activity, significantly reduced cytotoxicity, and a generally improved treatment index of more than 10 times, or even more than 260 times, compared with cannabidiol.

This invention discloses a method for preparing two-dimensional chiral graphyne via terminal alkyne coupling. The method uses a chiral graphyne framework as the building block and hexaethynylbenzene and chiral terminal alkyne monomers as co-building units. By optimizing the catalytic system (a combination of copper-based catalyst and organic base) and controlling key process parameters such as coupling reaction time, a one-pot in-situ construction of two-dimensional chiral graphyne is achieved. This invention significantly shortens the synthetic route, greatly simplifies the processing steps, and avoids damage to the intrinsic conjugated framework of graphyne during post-modification processes, providing a new approach for obtaining structurally complete and stable two-dimensional chiral graphyne materials.

The present invention relates to a process of hydrogenating an alkyne selectively to an alkene by hydrogen using a hydrogenation catalyst which is palladium supported on a carrier in the presence of an additive mixture of an organic phosphorus compound (AP) and an organic sulphur compound (AS).

The application designs and synthesizes polysaccharide construction monomers (mannose, galactose or glucose) containing azide group and terminal alkyne group at the same time, realizes monosaccharide molecular coupling through copper catalyzed azide-alkyne click chemistry reaction (CuAAC), the rate of copper catalyzed azide-alkyne click chemistry is fast, the yield is high, the product is stable, there is no by-product, the synthesis of polysaccharide molecules composed of single kind of polysaccharide construction monomers and sequence controllable polysaccharide molecules composed of different kinds of polysaccharide construction monomers can be realized. Similarly, the azide-alkyne click chemistry is used for modifying fluorescent molecules at the end of the polysaccharide molecule, and the synthesis of sequence controllable polysaccharide molecules with fluorescent properties is realized.

A method for removing acetylene from ethane cracking to olefins involves selectively hydrogenating a mixture of C2 and C3 hydrocarbons from ethane cracking to remove acetylene, propyne, and propadiene. Reaction conditions: inlet temperature 50℃~95℃, pressure 1.5~3.0MPa, space velocity 8000~14000h⁻¹ ‑1 The catalyst support is alumina or mainly alumina, and has a bimodal pore distribution structure with a micropore size of 40–70 nm and a macropore size of 200–500 nm. The specific surface area of ​​the catalyst support is 4–15 m². 2 / g. The catalyst contains at least Pd, Fe, Ni, and Cu, with Pd supported in both microemulsion and solution formats, Ni and Cu supported in microemulsion, and Fe supported in solution. The solution-supported Pd and Fe are mainly loaded in micropores of 40–70 nm, while the microemulsion-supported Ni, Cu, and Pd are mainly distributed in macropores of 200–500 nm. This alkyne removal method exhibits low reduction temperature, low "green oil" formation, and excellent catalytic performance and anti-coking properties.

The present application relates to the technical field of alkali metal-based battery, and particularly relates to a flame-retardant electrolyte and an alkali metal-based battery thereof. The flame-retardant electrolyte provided by the present application comprises a solvent, the solvent comprises 10% to 100% of an ether-based phosphazene solvent in terms of volume percentage, and the ether-based phosphazene solvent has the following general structure formula (I): formula (I); wherein one or more of R1 to R6 is selected from a chain ether group which is substituted or unsubstituted by a halogen atom, a cyano group, an olefin group or an alkyne group, and R7 is selected from a cyclic ether group which is substituted or unsubstituted by a halogen atom, a cyano group, an olefin group or an alkyne group. The flame-retardant electrolyte provided by the present application adopts an ether-based phosphazene solvent with a specific structure, compared with the traditional phosphazene compound which can only be used as an electrolyte additive, the coordination effect of the introduced ether group greatly improves the solubility of the phosphazene solvent to lithium salt, so that the phosphazene solvent can be used as the main solvent of the electrolyte for the flame-retardant electrolyte of a wide-temperature and high-pressure lithium battery.

The application relates to a method for synthesizing dihydropyrrolo[2,3-c]pyrazole analogs. Specifically, under the catalysis of a transition metal and a bidentate ligand, dihydropyrrolo[2,3-c]pyrazole analogs can be obtained in high selectivity by using the bidentate ligand synergy, taking pyrazolinone as raw material and reacting with 1,3-alkyne under the action of triethylenediamine. The application uses cheap and commercially available 1,3-alkyne and easily obtained pyrazolinone, and a series of heterocyclic compounds with potential medicinal value are obtained in high selectivity under simple and mild conditions.

Embodiments of the present application provide a positive electrode active material, a secondary battery, and an electric device. The positive electrode active material includes composite particles and a carbon-containing high molecular polymer material coated on the outside of the composite particles. The composite particles include lithium-iron-manganese phosphate particles and metal oxide particles at least partially coated on the outside of the lithium-iron-manganese phosphate particles. The carbon-containing high molecular polymer material includes a conjugated high molecule derived from a substituted or unsubstituted aliphatic alkyne. A heteroatom is doped in the conjugated high molecule, and the heteroatom includes a Group IA element or a Group VIIA element. Thus, the capacity of the secondary battery can be improved, and the thermal stability can be improved.

This invention belongs to the field of electrochemical catalysis and carbon capture and utilization technology. This invention relates to a fullerene-like Cu... 33 Cluster isomers, their preparation methods, and applications; the chemical formula of the cluster isomer is [Cu]. 33 (Ph3P)4(C≡CC6H4NH) 12 ] + (denoted as Cu) 33 -1 and Cu 33 -2), possessing unique Cu 13 @Cu 20 Core-shell structure, in which Cu 13 The core is an icosahedral structure, exhibiting 1S 2 1P 6 The octet closed-shell superatomic structure; the isomers are initiated by the rotation of three surface alkyne ligands relative to the other nine ligands, forming different intramolecular π-π stacking interactions and electronic structures. This invention modulates the electron distribution of catalytic active sites through a surface ligand asymmetry strategy, lowers the energy barrier of C-C coupling reactions, and suppresses hydrogen evolution side reactions, providing a new paradigm for designing highly selective CO₂ reduction catalysts.

The present application relates to a kind of biological ortho prodrug, composition and its application, specifically disclose a kind of drug prodrug with substituted acrylamide or substituted vinyl sulfonamide structure, is obtained by the reaction of covalent warhead comprising active drug and N-alkyl hydroxylamine.The drug prodrug can be released by Retro-Cope elimination reaction and Cope elimination reaction with tension alkyne, and the release rate can reach more than 90%, to realize on-demand activation active warhead, effectively solve the off-target problem of covalent inhibitor.In addition, by introducing the drug or fluorophore containing hydroxyl / amine group in the propargyl position of tension alkyne, the intermediate produced after Cope elimination reaction of tension alkyne can further undergo elimination reaction, release the drug or fluorophore containing hydroxyl / amine group, realize combined therapy or real-time monitoring of drug release.The above-mentioned drug prodrug and the composition formed by the combination of tension alkyne have good application prospect in the preparation of drug delivery system or active drug.

The present application relates to a kind of xylan-based gel microspheres and its preparation method and application.The preparation method includes: xylan is acyl halogenated modification, the product is reacted with azide reagent again, and finally azido xylan derivative is obtained;Alkynylated copolymer is prepared with the mixture of acrylic monomer and acrylic ester monomer;Azido xylan derivative, alkynylated copolymer and catalyst system are mixed to form reaction liquid, then the reaction liquid is spray dried, and azide-alkyne cycloaddition reaction occurs in the process of spray drying and is crosslinked.The gel microspheres prepared by the method of the present application have pH responsiveness and flora triggerability, solving the problems of complex process, low targeting accuracy of existing xylan-based colon targeting carrier.The method of the present application ingeniously combines efficient click chemistry with easy industrialization spray drying technology, and is expected to realize the continuous, large-scale production of bio-based intelligent gel microspheres.