925 results about "Alkyne" patented technology

Provided are compounds of Formula I:nucleosides, nucleoside phosphates and prodrugs thereof, wherein R6 is CN, ethenyl, 2-haloethen-1-yl, or (C2-C8)-alkyn-1-yl. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.

The invention discloses a polyimidazolone compound as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving a bilateral alkyne ester compound, amidine hydrochloride, a catalyst and a desalting agent in an organic solvent, and carrying out polymerization reaction to obtain the polyimidazolone compound. The polyimidazolone compound with the five-membered ring is selectively generated, and the method has the advantages that monomers are easy to obtain, operation is easy, and by-products are low in toxicity. The polyimidazolone compound prepared by the invention has better machinability and has potential application value in the aspects of metal ion detection and biogenic amine detection.

The invention discloses a battery and a preparation method thereof. The battery comprises a positive electrode lithium supplementing material and an electrolyte, the positive electrode lithium supplementing material comprises at least one of lithium nickelate, lithium ferrite and lithium oxide; the electrolyte comprises a silicon-based fluorophosphate compound as shown in a formula I: # imgabs0 #, wherein R1, R2 and R3 are independently H, F, alkyl of C1-C4, fluoroalkyl of C1-C4, alkenyl of C2-C4, fluoroalkenyl of C2-C4, alkynyl of C2-C4, fluoroalkynyl of C2-C4, cycloalkane of C5-C7, phenyl substituted by R4 or benzyl substituted by R5; r1, R2, R3, R4 and R5 are independently alkyl groups of C1-C4, alkylene groups of C2-C4, alkyne groups of C2-C4, fluoro alkyl groups of C1-C4, fluoro alkylene groups of C2-C4 or fluoro alkyne groups of C2-C4. The compound shown in the formula I is added into the electrolyte, so that the problems of gas expansion and lithium precipitation caused by a positive electrode lithium supplementing material can be solved, and the battery performance is improved.

A method for visible light-mediated chemical modification of a polypeptide or protein based on cysteine includes the following steps: allowing a cysteine residue on a cysteine-containing oligopeptide, polypeptide, or protein to undergo a reaction with an activating reagent to generate a free radical precursor in situ; and subjecting the free radical precursor to desulfurization under photocatalytic condition, and allowing the generated free radical intermediate to undergo an addition reaction with an olefin or an alkyne, such that sulfhydryl removal and carbon-carbon bond construction are achieved to produce a chemical modification product of the polypeptide and protein. The method cleverly avoids the influence on the chiral center, and thus the chirality of the amino acid residue can be retained. The method is conducive to well avoiding the occurrence of side reactions, and thus the efficiency of the entire conversion is very high.

The invention is applicable to the technical field of nano material preparation, and provides a preparation method of a two-dimensional acetylene-rich carbon / molybdenum sulfide heterostructure hydrogen production catalyst, which comprises the following steps: adding molybdenum sulfide into a solution to prepare a suspension A; adding soluble cuprous salt into the turbid liquid A in an inert atmosphere to obtain a mixed liquid B; alkynyl benzene is added into an organic solvent, and a mixed solution C is obtained; dropwise adding the mixed solution C into the mixed solution B under a continuous stirring condition, and reacting to obtain a mixed solution D; centrifuging the mixed solution D to obtain a precursor E; and cleaning the precursor E, and carrying out vacuum drying to obtain the two-dimensional acetylene-enriched carbon / molybdenum sulfide heterostructure hydrogen production catalyst. No additive is needed in the preparation process, and the product purity is high; by constructing a special two-dimensional heterostructure, the problem of molybdenum sulfide is solved, and the intrinsic activity and stability of the material are remarkably improved. The preparation method has the advantages of easily available raw materials, simple process, low cost and environmental protection, and is suitable for industrial production.

The present invention relates to a catalytically active material, the preparation thereof, and the use of the catalytically active material, e.g. in the catalytic oxidation of CO to CO2 or in the catalytic hydrogenation of alkyne. The catalytically active material comprises a support5 comprising a metal oxide, and atomically dispersed noble metal on the surface of the support, wherein the metal oxide is selected from TiO2, CeO2, ZnO, SnO2, Ga2O3, In2O3, ZrO2, and Fe2O3, the noble metal is selected from Pt, Pd, Rh, and Au, and the catalytically active material is obtainable by a method comprising a step of non-thermal plasma treatment in the presence of O2.

The invention discloses an indole sophocarpidine derivative photoaffinity active molecular probe which is formed by connecting an active group and a reactive group, the active group is a sophocarpidine derivative, the reactive group is a substance containing a diaziridine group and an alkyne group, and the chemical formula of the sophocarpidine derivative is as shown in the formula I. The invention further discloses a preparation method of the indole sophocarpidine derivative photoaffinity active molecular probe. After Spodoptera frugiperda Sf9 cells are treated by the indole sophocarpidine derivative photoaffinity active molecular probe for 72 hours, the inhibition rate can reach 86.33%, potential target protein when the sophocarpidine derivative acts on the Sf9 cells can be determined by utilizing the indole sophocarpidine derivative photoaffinity active molecular probe, targeted modification of sophocarpidine is facilitated, and the application range of the indole sophocarpidine derivative photoaffinity active molecular probe is widened. Further, matrine pesticides with excellent insecticidal activity are efficiently synthesized, and agricultural pests are better prevented and controlled.

The invention provides a medical hydrophilic coating and a preparation method and application thereof.The coating comprises a substrate layer and a functional layer, the substrate layer is arranged on the surface of a medical base material, the functional layer is arranged on the surface of the side, away from the medical base material, of the substrate layer, and the substrate layer comprises a substrate modification material containing a first reactive functional group; the functional layer comprises a phosphorylcholine compound containing a second reactive functional group; the substrate layer and the functional layer are connected through a chemical bond formed by the first reactive functional group and the second reactive functional group; the substrate modification material contains a third reactive functional group, and the substrate layer is connected with the medical base material through a chemical bond formed by the third reactive functional group and hydroxyl or amino on the surface of the medical base material; when the first reactive functional group is an azide group, the second reactive functional group is an alkynyl group; or when the first reactive functional group is the alkynyl group, the second reactive functional group is the azide group. Chemical bonds are formed through azido and alkynyl, multiple chemical reactions are not needed, and the uniformity of the coating is improved.

The invention relates to a method for bonding a layer of elastomeric material (CE) to an aluminum substrate (SM), characterised in that it comprises the following steps: a) treating the surface (S) of the aluminum substrate (SM) in order to roughen it; b) treating the surface (S) by means of argon plasma; c) exposing said surface (S) to a plasma in the presence of a gaseous chemical precursor selected from the group consisting of epoxides, acrylics, olefins, alkynes and imides, until a deposit of chemical substances having a thickness of 5 nm to 110 nm is obtained; d) bringing the layer of elastomeric material (CE) into contact with the surface (S) of the aluminum substrate (SM); e) vulcanizing the layer of elastomeric material, said step c) being carried out at a low pressure, i.e. At a pressure of 10-2 mbar to 10-5 mbar.

The present invention discloses a class of imide ring-containing dimercapto monomers, imide ring-containing diene monomers and preparation methods thereof, a light-responsive polyimide material and preparation method thereof, and relates to the technical field of light-driven materials. The present invention uses a dibasic acid anhydride as the basic monomer unit, and prepares a dimercapto monomer containing an imide structure and a monomer containing an imide ring-containing diene monomer by reacting with a monothiol compound and a monoalkyne compound, respectively. The two monomers are subjected to a thiol-alkyne click reaction to finally obtain a high molecular weight polyimide. The polyimide obtained by the present invention has excellent solubility, high tensile strength, good heat resistance and light transmittance; the polyimide material is placed under an ultraviolet lamp for uneven photocrosslinking to quickly obtain a light driver with excellent reversible driving performance.

The present invention discloses a method for preparing enol by selective hydrogenation of alkynol. By adding an acidic substance to adjust the pH value of the reaction system and adding crown ether to inhibit the two main side reactions of self-coupling and over-hydrogenation of terminal alkyne, the purpose of improving low selectivity is achieved. The product has a pure odor and mild reaction conditions.

The invention discloses selenium-containing unsaturated polyesteramide and a preparation method thereof, and the preparation method comprises the following steps: mixing and dissolving a diamine compound, propiolic acid ester and selenolactone in an organic solvent, and carrying out chemical reaction to obtain the selenium-containing unsaturated polyesteramide. A diamine compound, propiolic acid ester and selenolactone are used as raw materials, selenium-containing unsaturated polyesteramide is generated through click polymerization reaction of selenol and alkyne, the novel preparation method of selenium-containing unsaturated polyesteramide is developed, and the prepared polyesteramide is narrow in molecular weight distribution, controllable in structure and adjustable in degradation rate, and can be used for preparing selenium-containing unsaturated polyesteramide. Long-term stability is good, multiple responsiveness is achieved, and optical performance is good; the raw materials are wide in source, tedious substrate synthesis is avoided, the steps are simple, the reaction conditions are mild, the polymerization speed is high, and efficient large-scale production can be achieved; no catalyst is needed, no by-product is generated, and extra purification is not needed.

According to the photopolymer system based on the fluorine-containing liquid crystal, the grating device and the preparation method of the grating device, the mixed liquid crystal containing the nematic liquid crystal and the fluorine-containing liquid crystal at the same time is adopted in the photopolymer system, and therefore the polarity and dielectric anisotropy of the mixed liquid crystal material are improved; the overall electro-optical performance, uniformity and stability of the photopolymer system are improved, so that a grating device prepared based on the photopolymer system has good optical characteristics of low haze while having relatively high diffraction efficiency. Specifically, fluorine-containing biphenyl liquid crystals, fluorine-containing alkyne liquid crystals and fluorine-containing difluoromethoxy liquid crystals of which the carbon atoms of flexible side chains are 2-5, and nematic liquid crystals of which the delta epsilon is not less than 10 are selected to jointly form mixed liquid crystals; and the balance and optimization between the diffraction efficiency and haze performance of the photopolymer system and the grating device prepared from the photopolymer system are realized.

The invention provides a conjugated frame encapsulated graphene functionalized polymer anti-corrosion anti-impact double-effect heat-conducting coating and a preparation method thereof, the method comprises the following steps: step S1, mixing graphene with a bromine source to prepare brominated graphene; step S2, adding a halogen monomer, a conjugated alkyne monomer, a catalyst and the brominated graphene obtained in the step S1 into a mixed solution, and inducing a conjugated frame to perform in-situ packaging on the surface of the graphene in an inert gas atmosphere to prepare conjugated frame packaged graphene; s3, performing high-temperature carbonization treatment on the conjugated frame packaged graphene obtained in the step S2, and permeating a corrosion-resistant matrix to prepare a conjugated frame packaged graphene functional polymer; and step S4, loading a heat conduction material and a thickening agent on the graphene functionalized polymer obtained in the step S3 to prepare the graphene functionalized polymer coating. The coating prepared by the invention has the characteristics of continuous conjugate frame, hierarchical pore structure and corrosion resistance and impact resistance, and is suitable for the field of protection of efficient heat exchange equipment.

The present disclosure relates to methods of treating or preventing cancer (e.g., advanced solid cancer) using Compound No. 1: (Compound No. 1) or a pharmaceutically acceptable salt thereof. The present disclosure also relates to pharmaceutical compositions and pharmaceutical kits suitable for the treatment or prevention.

The invention provides an alkyne selective hydrogenation catalyst with high activity and high selectivity and a preparation method thereof. The catalyst is a compound of metallic nickel and alkali metal hydride and is marked as nickel-alkali metal hydride, high catalytic reaction activity and high olefin selectivity can be both considered by regulating and controlling the proportion of the nickel elementary substance and the alkali metal hydride, and compared with the metallic nickel and the alkali metal hydride as the catalyst, the catalyst has the advantages that the catalytic activity is high; the catalytic activity and the olefin selectivity are greatly improved. The nickel-alkali metal hydride catalyst is suitable for alkyne selective hydrogenation reaction in a high-temperature and high-pressure fixed bed gas phase reaction system, is also suitable for alkyne selective hydrogenation reaction in a high-temperature and high-pressure reaction kettle liquid-solid phase reaction system, and has a good application prospect.

The utility model discloses a hydrogen storage and supply device and a hydrogen fuel cell heat and power cogeneration system, and relates to the technical field of fuel cells. The hydrogen storage and supply device realizes normal-temperature and normal-pressure storage of hydrogen on the basis of a liquid organic matter hydrogen storage technology, and the principle is that hydrogen storage is realized by virtue of reversible reaction and hydrogenation reaction of unsaturated liquid organic matters such as olefin, alkyne or aromatic hydrocarbon and hydrogen, and hydrogen release is realized by virtue of dehydrogenation reaction. According to the liquid organic matter hydrogen storage technology, the hydrogen storage density is 5%-10%, and the hydrogen storage amount is large; and the hydrogen storage carrier is a liquid organic matter, normal-temperature and normal-pressure transportation can be achieved, convenience and safety are achieved, the requirement for the hydrogen liquid tank is low, and hydrogen leakage is basically avoided during transportation. And during dehydrogenation reaction, the temperature required by hydrogen desorption is low, the energy consumption is low, the hydrogen desorption rate is adjustable, and the hydrogen desorption device can be adapted to various hydrogen fuel cells. The hydrogen fuel cell heat and power cogeneration system collects and utilizes the lost heat of the cell, so that the comprehensive utilization rate of the hydrogen fuel cell is improved.

The invention relates to a preparation method and application of a triazole derivative with an antidepressant effect, and belongs to the technical field of synthesis of drugs. Based on a 2-[3-nitrile group-4-(2-isobutoxy)-phenyl]-4-methylthiazole-5-formic acid structure, terminal alkyne is introduced into the structure, and the triazole derivative with the antidepressant effect is prepared. According to the present invention, the novel compounds are obtained through the reaction of the compounds and the azide compounds through the click reaction, and the test results prove that the obtained compounds have good anti-inflammatory activity on LPS-induced BV2 cells, are expected to be used for the treatment of depression, and have strong guiding effects on the research and development of anti-depression drugs.

The invention discloses a preparation method of a six-membered azaspiro dihydrobenzofuran compound. According to the method, a C2-alkyne benzofuran derivative is taken as a raw material, metal palladium is taken as a catalyst, and a corresponding product is generated through reaction in an organic solvent at the temperature of 40-120 DEG C under the combined action of a ligand and acetic anhydride. Under the action of palladium, a ligand, a solvent and acetic anhydride, alkyne triple bonds and indole double bonds are subjected to triple addition and bicyclic addition, and rapid construction of a six-membered azaspiro structure dihydrobenzofuran product is achieved. The reaction conditions are mild, the operation is simple and convenient, and the method has the advantages of easily available reaction raw materials, wide substrate applicability, excellent yield and enantioselectivity, easily separated target products and the like.

In some aspects, the present disclosure pertains to systems for forming crosslinked reaction products that comprises (a) a first composition that comprises a first multifunctional molecule that comprises a plurality of first reactive moieties that comprise azide groups and (b) a second composition that comprises a second multifunctional molecule that comprises a plurality of second reactive moieties that comprise cyclic alkyne groups, where at least one of the first and second multifunctional molecules is a reactive multi-arm polymer and where at least one of the first and second multifunctional molecules comprises an iodinated core. Other aspects of the present disclosure include crosslinked networks formed from such first and second multifunctional molecules and methods of treatment based on crosslinked networks formed from such first and second multifunctional molecules.

The application provides a catalyst for preparing an enol from an alkyne alcohol, a preparation method and a method for preparing the enol by using the catalyst. By precisely controlling the particle size, specific surface area and added toxicant of the Lindlar catalyst, the catalytic efficiency can be significantly improved, and the catalyst performance is quantified with each parameter, so that the catalyst can be widely applied in industrial production.

Disclosed herein are deuterated compounds and transition metal catalyzed methods for making deuterated compounds. The disclosed methods are regioselective and enantioselective and may be utilized to prepare isomerically and / or enantiomerically pure or enriched deuterated compounds. The disclosed methods also may be modified in order to prepared fluorinated compounds.

The invention discloses silver-copper alloy nanoparticles with a core-shell structure as well as a preparation method and application of the silver-copper alloy nanoparticles. The core of the core-shell structure silver-copper alloy nanoparticle is a silver-copper alloy nanoparticle, and the shell of the core-shell structure silver-copper alloy nanoparticle is a ZIF-8 coating layer. The preparation method of the silver-copper alloy nanoparticles with the core-shell structure comprises the following steps: 1) preparing the silver-copper alloy nanoparticles; (2) preparing surface modified silver-copper alloy nanoparticles; and 3) dispersing the surface-modified silver-copper alloy nanoparticles, zinc salt and 2-methylimidazole in methanol for reaction. The silver-copper alloy nano-particles with the core-shell structure have the advantages of rich active sites, good catalytic effect, high cycling stability, mild reaction conditions, simple preparation method and the like, can be used for carboxylation of terminal alkyne and CO2 to generate propiolic acid compounds and carboxylation of propargyl amine and CO2 to generate 2-oxazolidinone compounds; and the method has a very wide application prospect.

The invention provides an alkynyl-rich covalent organic framework material diaphragm for a zinc-iodine battery and a preparation method of the alkynyl-rich covalent organic framework material diaphragm, and the diaphragm comprises an alkynyl-rich covalent organic framework material, a zinc conduction diaphragm and amino graphene. And the conductivity of the battery is effectively improved. The composite diaphragm can effectively inhibit the growth of zinc dendrites, avoids the problem of battery short circuit caused by the fact that the zinc dendrites penetrate through the diaphragm, and prolongs the service life of the battery. Meanwhile, by adding the amino graphene, the electronic conductivity of the battery is enhanced, the ion migration rate is increased, and the charge-discharge efficiency is improved. Due to the existence of alkynyl, the surface affinity and the conductivity of the material are enhanced, and the energy density and the cycling stability of the zinc-iodine battery are greatly improved. As the diaphragm material has better chemical stability, the diaphragm material can effectively reduce side effects of internal reaction of the battery, reduce negative effects caused by zinc metal corrosion, and further improve the overall performance of the battery.

The invention discloses a preparation method and application of a framework nucleic acid synergistic enhanced click chemistry and DNAzyme catalytic electrode. According to the present invention, the azide group modified split G-quadruplex fragment A is assembled on the double-stranded DNA (dsDNA) edge of the DNA tetrahedron through the Hoogsteen hydrogen bond, such that the reasonable spatial distribution of the reactants is achieved, and the click chemical reaction efficiency on the interface is improved; under the catalytic condition of Cu (I), the alkyne group modified split G-quadruplex fragment B and the fragment A assembled on the tetrahedral scaffold form a complete G-quadruplex through a click chemical reaction. And further, the compound is compounded with Hemin, so that the formed G-quadruplex / hemin compound has peroxidase-like activity. Meanwhile, the nucleic acid framework with the strong electronegativity characteristic further enhances the response current of catalytic oxidation TMB, and sensitive detection of Cu < 2 + > and alkaline phosphatase is achieved.

The invention relates to a heterocyclic alkynyl-substituted amide derivative as shown in a formula (I), and a preparation method and application of the heterocyclic alkynyl-substituted amide derivative. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient and application of the compound or the pharmaceutical composition in treating and / or preventing related diseases mediated by PRMT5.

Methods of using high-purity alkynes substantially free of residual alkyl halides, water and / or carboxylic acids and their use (e.g., in formulations) for enhanced passivation of metallic substrates.

A method of attaching an azide moiety to a biomolecule. The method entails contacting a biomolecule in a solution with an azide and an oxidizing agent, for a time and at a temperature wherein at least one azide moiety is covalently bonded to the biomolecule to yield an azidylated biomolecule. The method can be used to identify hydrophobic microenvironments in soluble proteins. Also, a method of attaching a reagent comprising an alkyne to a biomolecule. The method comprises reacting a biomolecule in a solution with an azide and a reagent comprising an alkyne, for a time and at a temperature wherein at least one reagent comprising an alkyne is covalently bonded to the biomolecule via triazole linkage.

The invention discloses a photopolymer type holographic recording medium and a preparation method and application thereof, the photopolymer type holographic recording medium comprises a writing monomer, and the writing monomer comprises epoxy resin and a polymerizable monomer, the polymerizable monomer is selected from an alkenyl naphthalene compound, an alkenyl anthracene compound, an alkenyl benzene compound, an acrylic acid compound, a methacrylic acid compound, an acrylate compound, a methacrylate compound, N-vinyl pyrrole, N-vinyl carbazole, N-vinyl imidazole, N-vinyl indole and N-vinyl pyrrolidone; the carbazole is at least one of trans-N-3-alkyne butenyl carbazole. According to the epoxy resin disclosed by the invention, the volume shrinkage of the polymerizable monomer after polymerization can be effectively reduced, the cationic polymerization of the epoxy resin can be accelerated while the polymerizable monomer forms free radical polymerization, and the photopolymer type holographic recording medium disclosed by the invention is high in light sensitivity, stable in holographic performance and high in volume holographic grating diffraction efficiency.

The invention relates to the technical field of hydrofining, and discloses a catalyst carrier, an alkyne selective hydrogenation catalyst, and preparation methods and applications of the catalyst carrier and the alkyne selective hydrogenation catalyst. According to the invention, Ag and Re are innovatively adopted as doping components in the catalyst carrier, and the dispersibility of Ag is greatly improved by utilizing the synergistic effect of Ag and Re. The alkene selectivity of the alkyne selective hydrogenation catalyst prepared by adopting the carrier provided by the invention is greatly improved, and the alkyne selective hydrogenation catalyst has long-period operation capability. The invention also provides an ethylene material flow hydrofining method carried out under the conditions of high CO and high H2, the method can efficiently remove high-concentration acetylene contained in the ethylene material flow, the catalyst provided by the invention is matched, extremely high ethylene selectivity can be obtained under the condition of high space velocity, long-term stable operation can be realized, and the method is suitable for industrial production. And the method is very suitable for industrial popularization and application.