554 results about "Alkyne" patented technology

Provided are compounds of Formula I:nucleosides, nucleoside phosphates and prodrugs thereof, wherein R6 is CN, ethenyl, 2-haloethen-1-yl, or (C2-C8)-alkyn-1-yl. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections.

The utility model discloses a hydrogen storage and supply device and a hydrogen fuel cell heat and power cogeneration system, and relates to the technical field of fuel cells. The hydrogen storage and supply device realizes normal-temperature and normal-pressure storage of hydrogen on the basis of a liquid organic matter hydrogen storage technology, and the principle is that hydrogen storage is realized by virtue of reversible reaction and hydrogenation reaction of unsaturated liquid organic matters such as olefin, alkyne or aromatic hydrocarbon and hydrogen, and hydrogen release is realized by virtue of dehydrogenation reaction. According to the liquid organic matter hydrogen storage technology, the hydrogen storage density is 5%-10%, and the hydrogen storage amount is large; and the hydrogen storage carrier is a liquid organic matter, normal-temperature and normal-pressure transportation can be achieved, convenience and safety are achieved, the requirement for the hydrogen liquid tank is low, and hydrogen leakage is basically avoided during transportation. And during dehydrogenation reaction, the temperature required by hydrogen desorption is low, the energy consumption is low, the hydrogen desorption rate is adjustable, and the hydrogen desorption device can be adapted to various hydrogen fuel cells. The hydrogen fuel cell heat and power cogeneration system collects and utilizes the lost heat of the cell, so that the comprehensive utilization rate of the hydrogen fuel cell is improved.

The application provides a catalyst for preparing an enol from an alkyne alcohol, a preparation method and a method for preparing the enol by using the catalyst. By precisely controlling the particle size, specific surface area and added toxicant of the Lindlar catalyst, the catalytic efficiency can be significantly improved, and the catalyst performance is quantified with each parameter, so that the catalyst can be widely applied in industrial production.

The invention relates to a heterocyclic alkynyl-substituted amide derivative as shown in a formula (I), and a preparation method and application of the heterocyclic alkynyl-substituted amide derivative. The invention also relates to a pharmaceutical composition containing the compound as an active ingredient and application of the compound or the pharmaceutical composition in treating and / or preventing related diseases mediated by PRMT5.

Methods of using high-purity alkynes substantially free of residual alkyl halides, water and / or carboxylic acids and their use (e.g., in formulations) for enhanced passivation of metallic substrates.

The invention relates to the technical field of polycarbonate polyols, and discloses a preparation method of carbon dioxide-based polycarbonate polyols, which comprises the following steps: adding an epoxy compound, a carborane derivative catalyst, a chain initiator and a chain transfer agent into a reactor, introducing carbon dioxide to replace air in the reactor, and reacting to obtain the carbon dioxide-based polycarbonate polyols. Then pressurizing, heating and stirring to carry out polymerization reaction, adding acid to terminate the reaction after the reaction is completed, and then purifying and drying to obtain the polycarbonate polyol, wherein the carborane derivative catalyst is prepared by the following preparation method: adding different substituted alkynes, decaborane, ethyl sulfide and toluene into a reaction flask in proportion in a nitrogen atmosphere, sealing the reaction flask, and heating and stirring to enable the decaborane to react with the different substituted alkynes. According to the method, a specific catalyst is used for replacing a traditional catalyst, and the reaction efficiency and the product molecular weight can be improved.

The invention discloses a continuous synthesis method of a cobalt-based alkyne precursor based on micro-reaction reinforcement, which belongs to the technical field of advanced electronic material preparation, and comprises the following steps: pre-cooling an n-hexane solution of Co2 (CO) 8 to-30 DEG C; the method comprises the following steps: introducing an n-hexane solution of Co2 (CO) 8 and 3, 3-dimethyl-1-butyne into a stacked microreactor array under the protection of nitrogen to react, and collecting a product after the reaction is completed. According to the present invention, the micro-channel reaction system containing the passivation layer is constructed, the substitution reaction process is precisely regulated and controlled, and the in-situ detection technology is combined so as to achieve the directional synthesis and collection of the specific coordination structure; the obtained product has excellent thermal stability and vapor pressure characteristics, and can meet the requirements of advanced semiconductor device manufacturing on precursor materials.

The application discloses a method for synthesizing organic acetylide ester through a palladium catalytic reaction and belongs to the field of organic synthesis. The organic acetylide ester is obtained through a cross-coupling reaction in the presence of a palladium catalyst, a phosphine ligand and an alkali, with terminal alkyne and di-tert-butyl dicarbonate as raw materials. The method has the advantages of high reaction yield, wide substrate range, good functional group compatibility, and the advantages of non-toxic and easy-to-obtain carbonyl source, simple operation steps and mild reaction conditions.

The application provides a kind of sodium sulfide nine hydrate and activated olefin / acetylene preparation polyether and its method, belong to sulfur-containing polymer technical field.The structural formula of polyether in the application, R 1 And R 2 Independently be substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl;The number of carbon atoms of the alkyl is 1-10, the number of carbon atoms of alkoxy is 1-10, the number of carbon atoms of aryl is 1-30, the number of carbon atoms of heteroaryl is 3-30;Substituted alkyl and substituted alkoxy independently are one or more;N is an integer of 2-4000.The application is used as sulfur source sodium sulfide nine hydrate, under the condition of no metal catalyst, polyether is synthesized by polymerization reaction;Reaction condition is mild, reaction is efficient, economic and environmental protection, meet the current green production concept and can avoid the use of dangerous reagent.

The invention discloses a method for synthesizing a benzodithiepinone derivative through metal-free catalysis, and belongs to the field of organic synthesis. According to the method, benzo disulfonylphenol ketone and alkyne are taken as raw materials, a dual-catalysis system composed of triethylene diamine and bis (diphenylphosphine) methane is adopted, a heating reaction is performed in a 1, 4-dioxane solvent, and the target seven-membered sulfur heterocycle (benzo [e] [1, 4] dithiepin-5-ketone compound) is obtained through separation and purification. According to the method, the problem of regioselective sulfuration of alkyne is effectively solved through a synergistic catalysis mechanism of organic amine and organic phosphine, and high-precision cyclization reaction of benzobissulfonylphenol ketone and alkyne is realized. The process is mild in reaction condition, free of inert gas protection, simple and convenient to operate and good in functional group tolerance, the atom economy can reach 100%, and an efficient and practical synthesis way is provided for construction of the benzo [e] [1, 4] dithiepin-5-ketone compound with a novel structure.

The invention discloses application of ferrocenyl conjugated microporous polymers Fc-CMPs in a composite solid propellant and the composite solid propellant, the ferrocenyl conjugated microporous polymers Fc-CMPs are porous organic polymers which take ferrocenyl groups as conjugated functional units and are connected through covalent acetylenic bonds, and the ferrocenyl conjugated microporous polymers Fc-CMPs have excellent thermal stability and permanent porosity, and can be used for preparing the composite solid propellant. The material is solid powder, is insoluble in a traditional organic solvent and does not migrate, and a ferrocene unit serves as a constituent part of a polymer framework and an oxidation-reduction active site and is dispersed in a two-dimensional conjugated network structure of a composite solid propellant. When being used as a burning rate catalyst to be applied to AP decomposition, the ferrocene burning rate catalyst can obviously reduce the high-temperature decomposition peak temperature of AP, and solves the migration problem of a traditional ferrocene burning rate catalyst in a composite solid propellant system. The Fc-CMPs are applied to an AP decomposition catalysis scene for the first time, and a new direction is provided for development of a composite solid propellant burning rate catalyst.

The application discloses a preparation method of a binary transition metal aluminide nanocatalyst and application thereof. First, a mixed metal salt solution is mixed with an ammonium carbonate solution to obtain a metal oxide precursor through co-precipitation. Then, the oxide precursor is mixed with a low-temperature composite molten salt and is subjected to thermal reduction under a specific atmosphere. Through simple post-processing, a single-phase binary transition metal aluminide nanocatalyst with high catalytic activity is obtained. The non-noble metal aluminide nanocatalyst prepared is applied to a reaction of catalytically selectively hydrogenating acetylenes to prepare olefin compounds. Under mild conditions, 99% conversion of reactants is achieved while maintaining 96% olefin selectivity. Compared with a traditional supported catalyst, the metal aluminum atom greatly regulates the electronic and geometric structures of the transition metal atom, effectively improves the catalytic activity, and significantly improves the structural stability of the catalyst. The material has high phase purity, is easy to separate and recycle, and has good application prospect.

The application discloses a method for regionally selective C3-H alkyne of triazolopyridazine compounds, and belongs to the field of organic synthesis. The method uses triazolopyridazine and high-valence iodine (III) alkyne reagent as raw materials, and a double catalytic system composed of Ph3PAuNTf2 (5 mol%), AgOTf (5 mol%) and 1,10-phenanthroline (20 mol%) in dichloromethane, and after reaction at 50 DEG C, the C3 alkyne product is obtained through purification. The method solves the problems of catalyst deactivation and poor selectivity caused by nitrogen-rich heterocyclic rings through gold / silver synergistic catalysis, and realizes precise functionalization of the C3 position. The reaction condition is mild, the substrate is widely applicable (R¹ contains various aryl groups and heteroaryl groups, and R² is compatible with different substituted aryl groups), the yield is 60% to 95%, the step is economical, and the method is suitable for large-scale preparation.

The utility model discloses a high-grade acetylene absorption device for preparing acetylene from natural gas. The high-grade acetylene absorption device comprises an absorption tower, a cracking gas inlet and a solvent outlet are formed in the lower part of the absorption tower, and a gas outlet and a solvent inlet are formed in the upper part of the absorption tower; a plurality of different types of tower internals are arranged in the absorption tower, and the different types of tower internals are respectively arranged at different heights of the absorption tower. According to the characteristics and requirements of the high-grade alkyne absorption process, by arranging different types of tower internals at different height positions in the same tower, the absorption effect and the anti-blocking performance are both considered, high operation flexibility is achieved, meanwhile, a design type with a relatively simple structure is adopted as much as possible to reduce the maintenance difficulty, and the cost is reduced. And the purpose of stably separating high-grade alkyne and crude acetylene by the device is achieved.

This application provides a battery electrolyte, a secondary battery, and an electrical device, belonging to the field of ion battery manufacturing. The organic solvent in the battery electrolyte includes a fluorinated dimethoxyalkane derivative having a general structural formula as shown in Formula I: wherein R1 and R2 are each independently selected from one of hydrogen-based, methoxy-based, ethoxy-based, C1-C6 chain alkyl, C3-C12 cycloalkyl, C2-C6 chain olefin, C2-C6 alkyne, and C6-C12 cycloolefin. This battery electrolyte can improve the cycle performance of the secondary battery.

This invention belongs to the field of photocrosslinking probe technology, specifically relating to a GUSB photocrosslinking probe, its preparation method, and its application. The GUSB photocrosslinking probe has the general chemical formula C0. 13 H 18 N2O6-R, wherein R is any one of the oxalic group elements or peptide bonds. The R group covalently connects the glucuronic acid recognition core and the photosensitive unit in the GUSB photocrosslinking probe, and the R group contains no more than 4 atoms, resulting in a small size and low steric hindrance. The GUSB photocrosslinking probe provided by this invention uses glucuronic acid as the recognition core, combined with a small-volume diazacyclopropane photosensitive unit and a terminal alkyne group, to achieve µM-level in-situ covalent capture of active GUSB in complex systems such as cells or tissues. The probe of this invention significantly improves positioning accuracy, sensitivity, data availability, quantification, and enrichment, while also possessing advantages such as modular synthesis, mild conditions, and strong system compatibility, effectively addressing the technical shortcomings of existing technologies that struggle to accurately obtain GUSB activity in situ under low-dose conditions.

The application discloses a lithium nickel manganese oxide positive electrode material and a preparation method thereof and a secondary battery, and relates to the technical field of lithium ion battery positive electrode materials. The preparation method comprises the following steps: mixing a lithium source, a manganese source, a nickel source, a solvent and a complexing agent to obtain a mixed solution; drying to obtain a lithium nickel manganese oxide precursor; crushing the lithium nickel manganese oxide precursor by means of airflow milling to obtain crushed material, and performing pre-burning, sintering and annealing treatment on the crushed material; wherein the complexing agent comprises one or more combinations of sodium nitrilotriacetate, ethylenediaminetetraacetate, diethylenetriaminepentaacetate, tartaric acid, gluconic acid, organic carbonate, ethyl acetate, ethyl formate, alkene, alkyne, aromatic hydrocarbon and ethylene. The application guarantees good complexing effect and dispersion effect, and the size is uniform, the particle size is controllable, and the positive electrode material obtained by the application does not need secondary modification (doping or coating) and can obtain excellent charge-discharge performance.

The invention discloses a preparation method of a 3-substituted isocoumarin compound, and belongs to the technical field of coumarin compound synthesizing.The preparation method comprises the steps that a 2-bromophenylboronic acid compound and alkyne serve as reaction substrates, a bidentate nitrogen ligand is added and dissolved in a solvent, under the action of alkali and a copper catalyst, a normal-pressure one-step cyclization reaction is conducted in the CO2 atmosphere, and the 3-substituted isocoumarin compound is obtained. The 3-substituted isocoumarin compound is obtained. According to the method, CO2, alkyne and 2-bromophenylboronic acid are used as reaction raw materials, cheap copper is used as a catalyst, the use amount is small, the 3-substituted isocoumarin is obtained through carbon-carbon coupling-cyclization by a CO2 activation one-step method under normal pressure, the conditions are mild, the cost is low, and the method is environmentally friendly.

The invention provides a method for preparing a chiral helicene compound through cyclization reaction of an iridium-catalyzed 3-aryl indazole biaryl compound and disubstituted alkyne. The method comprises the following steps: under the action of an iridium catalyst, a chiral cyano phosphorus-oxygen ligand and an additive, carrying out an intermolecular asymmetric carbon-hydrogen bond activation reaction on a 3-aryl indazole biaryl compound and disubstituted alkyne, and after the reaction is finished, separating to obtain the chiral diazaspirene-containing compound, according to the invention, synthesis of the chiral helicene compound is realized through a transition metal catalysis asymmetric carbon-hydrogen bond activation method, the research technology of Cp metal catalysis asymmetric carbon-hydrogen bond activation is further developed, and the synthesis strategy of the chiral helicene compound is expanded at the same time; reaction substrates are wide in universality, and chiral control in the reaction process is realized through the chiral cyano phosphine oxide, so that the product has very high enantioselectivity; various chiral helicene compounds are synthesized, the synthesis method is simple and convenient, and the atom economy is high.

The present invention relates to a composition ("TSP-DNA Oligo") comprising: a thermostable peptide ("TSP"), wherein the peptide comprises: an amino acid sequence as set forth in SEQ ID NO: 1 or SEQ ID NO: 2 or SEQ ID NO: 3 or SEQ ID NO: 4, or an amino acid sequence with at least about 92% sequence identity to a sequence as set forth in SEQ ID NO; 1, or SEQ ID NO: 2, or SEQ ID NO: 3 or SEQ ID NO: 4; and a "DNA Oligo" linked to the thermostable peptide through a linker, wherein the linker comprises: an azide group, an alkyne group, an isocyanate group, or a tetrazole group; wherein the "DNA oligo" comprises a promoter sequence for a T7, T3, SP6 RNA polymerase, or a known variant of said promoter sequence, or a sequence complementary to said promoter sequence or said variant.

The application belongs to the technical field of catalytic synthesis, and particularly relates to application of a Lewis acid-base pair in catalyzing polymerization of functionalizable monomers. Common polymerization methods have poor controllability for polymerization of monomers containing polyene groups, alkyne groups and conjugated diene groups, and the molecular weight of the obtained polymer is uncontrollable at low monomer conversion, and the molecular weight distribution is wide, and crosslinking occurs at high monomer conversion. The application utilizes a specific Lewis acid-base pair, and by adjusting the electronic effect and steric hindering effect of the Lewis acid and the Lewis base, active controllable polymerization of the functionalizable monomers can be catalyzed, and a polymer with a clear structure and containing functionalizable sites is obtained, the molecular weight is controllable, the molecular weight distribution is narrow, the end group structure is controllable, the position and density of the functionalizable sites are conveniently adjusted, an efficient platform is provided for post-modification preparation of functional high molecular materials, and functional high molecular materials are prepared by combining click reaction.

The invention relates to the technical field of environmental protection, and discloses a preparation process of a hydrophilic modified polysulfone fiber membrane, which comprises the following steps: carrying out click reaction on azido polysulfone and an alkynyl quaternary ammonium salt intermediate to obtain polysulfone containing triazole, hydroxyl and quaternary ammonium salt functional groups, and spinning by a dry-wet spinning method to obtain the hydrophilic modified polysulfone fiber membrane. Hydrophilic ether bonds, hydroxyl groups and quaternary ammonium salt groups are introduced, so that the surface hydrophilicity of the polysulfone fiber membrane is remarkably improved; triazole and hydroxyl groups contained in the polysulfone fiber membrane can form coordinate bonds with Hg < 2 + >, so that a very good chelating adsorption effect is achieved, and the adsorption performance and the adsorption capacity of the polysulfone fiber membrane on the Hg < 2 + > are improved. Meanwhile, the polysulfone fiber membrane contains a cationic quaternary ammonium salt group which can form good electrostatic interaction with Cr2O7 < 2->, so that the adsorption performance and the adsorption capacity of the polysulfone fiber membrane on the Cr2O7 < 2-> are further improved.

The disclosed and claimed subject matter relates to formulations comprising a combination of (i) one or more alkynes and (ii) one or more tertiary alcohols and their use for enhancing passivation of metal substrates.

The application provides a sulfide compound for inhibiting copper corrosion, and a structural formula of the sulfide compound is as follows: The application adds mercaptan compounds, alkyne and a photoinitiator into ethanol to obtain a mixed solution, then immerses a copper metal sheet into the mixed solution, and under the action of ultraviolet light, a click reaction occurs to synthesize the sulfide compound containing a C-S-C bond, so as to inhibit the corrosion of the copper metal and protect the copper metal, and the sulfide compound has a good effect of inhibiting the corrosion of the copper.

The application discloses a bonded imine three-component spherical COF-based stationary phase and a preparation method and application thereof, and the preparation method comprises the following steps: S1, synthesizing an imine three-component spherical COF containing an alkyne group bonding arm; S2, bonding monosubstituted 6-azido-6-deoxy-3,5-dimethoxy anilino carbamoylated beta-cyclodextrin to the three-component spherical COF prepared in the step S1 by means of a click chemistry method to prepare a bonded imine three-component spherical COF-based chiral stationary phase. The bonded imine three-component spherical COF-based stationary phase has the advantages of simple and convenient synthesis process, good stability of the prepared bonded imine three-component spherical COF-based stationary phase and good application prospect in HPLC separation.

The invention discloses a copper porphyrin conjugated acetylene polymer composite material, a preparation method and application of the copper porphyrin conjugated acetylene polymer composite material in biological mercaptan photoelectric detection, the composite material comprises an electrochemical reduction graphene oxide layer, a poly (1, 4-diacetylene benzene) layer and a copper porphyrin conjugated acetylene copolymer layer, and the three layers form a layered composite structure through pi-pi interaction. The copper porphyrin conjugated acetylene copolymer is formed by copolymerization of a 1, 4-diacetylene benzene monomer and a copper-coordinated 5, 10, 15, 20-tetra (4-acetylene phenyl) porphyrin monomer through a Sonogashira coupling reaction, and the composite material utilizes a double recognition site mechanism that a Cu-S coordinate bond is formed by a porphyrin center and sulfydryl and an acetylene bond and the sulfydryl are subjected to a click reaction under illumination. The high-sensitivity and high-selectivity detection on the L-cysteine and the reduced glutathione is realized, and the detection limit on the L-cysteine can reach 2.3 mu M.

The application discloses a tetravalent platinum ester alkyne complex, a degradable high polymer, a nanomicelle and a preparation method and application thereof; the structural formula of the tetravalent platinum ester alkyne complex is shown as formula (I); the preparation method of the degradable high polymer is as follows: the tetravalent platinum ester alkyne complex is prepared first; then the obtained tetravalent platinum ester alkyne complex and diamine and monomethyl ether polyethylene glycol mPEG-NH2 are clicked to obtain a triblock high polymer. The nanomicelle of the degradable high polymer is also disclosed. The tetravalent platinum ester alkyne complex disclosed by the application can specifically respond to reducing substances in a tumor microenvironment, and the enamine ester structure generated by the reaction of the tetravalent platinum ester alkyne complex with diamine also has the property of responding to an acidic environment; the high polymer has mild and simple preparation conditions, the molecular weight can reach 35200, and the platinum drug loading capacity is as high as 33.91%; the nanomicelle can efficiently degrade and release anticancer active drugs in the tumor microenvironment, and has high antitumor activity and low cytotoxicity.

The present disclosure relates to formulations comprising Compound No. 1: or a pharmaceutically acceptable salt thereof. The present disclosure also relates to uses of the formulations, e.g., in treating or preventing cancer.

The invention relates to the technical field of biological medicines, particularly discloses synthesis and application of a double-target nucleic acid molecule, and provides a strategy method for connecting two nucleic acid chains through a click chemical reaction. A connection unit of triazole is generated between the two nucleic acid chains through a click chemical reaction between a nucleic acid chain (Strand 1) of an azide group and a nucleic acid chain (Strand 2) of an alkyne group, and four connection modes are selected between 5'of the Strand 1 and 3 'of the Strand 2, between 5' of the Strand 1 and 5 'of the Strand 2, between 3' of the Strand 1 and 3 'of the Strand 2, and between 3' of the Strand 1 and 5 'of the Strand 2. Furthermore, two nucleic acid chains connected with triazole are respectively combined with complementary nucleic acid chains according to complementary base pairing, so as to prepare a double-target oligonucleotide drug.

The application discloses an alkynyl-modified covalent organic framework, a stable radical covalent organic framework based on a D-A structure, and a preparation method and application thereof; the alkynyl-modified covalent organic framework comprises an alkynyl-functionalized main structure with a benzene ring as a center, provides a large condensed ring pi system to adjust electronic properties, and the main framework has high crystallinity and is rich in alkynyl; the strong intermolecular pi-pi stacking caused by the highly conjugated rigid planar skeleton of the main framework leads to high charge carrier mobility; and the alkynyl in the alkynyl-functionalized main chain can undergo an addition reaction to form a stable radical framework and a COF two-dimensional layered structure of a strong electron donor-acceptor structure, has a wide absorption spectrum, and is favorable to absorption of sunlight. After irradiation with simulated sunlight, the temperature can reach 76.8 DEG C, and the alkynyl-modified covalent organic framework has a good application prospect as a light-heat conversion material; the preparation method for post-synthetic modification of the alkynyl has high yield and can be used for large-scale preparation.